LOCUS       NC_012625               7493 bp    DNA     circular CON 30-JUL-2013
DEFINITION  Chlamydia trachomatis plasmid pSW4, complete sequence.
ACCESSION   NC_012625
VERSION     NC_012625.1  GI:228292900
DBLINK      BioProject: PRJEA167484
KEYWORDS    .
SOURCE      Chlamydia trachomatis
  ORGANISM  Chlamydia trachomatis
            Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
            Chlamydia/Chlamydophila group; Chlamydia.
REFERENCE   1
  AUTHORS   Clarke,I.
  TITLE     Co-evolution of genomes and plasmids within Chlamydia trachomatis
            and the emergence in Sweden of a new variant strain
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7493)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (29-APR-2009) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 7493)
  AUTHORS   Seth-Smith,H.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-OCT-2008) Seth-Smith H.M., Pathogen Genomics,
            Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus,
            Hinxton, CB10 1SA, UNITED KINGDOM
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from FM865441.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..7493
                     /organism="Chlamydia trachomatis"
                     /mol_type="genomic DNA"
                     /strain="Sweden4"
                     /serovar="F"
                     /db_xref="taxon:813"
                     /plasmid="pSW4"
     rep_origin      1..88
                     /note="putative origin of replication; contains 4 copies
                     of a 22bp repeat"
     gene            165..1082
                     /locus_tag="PSW4_1"
                     /db_xref="GeneID:7803142"
     CDS             165..1082
                     /locus_tag="PSW4_1"
                     /codon_start=1
                     /transl_table=11
                     /product="putative virulence plasmid integrase"
                     /protein_id="YP_002842022.1"
                     /db_xref="GI:228292901"
                     /db_xref="GeneID:7803142"
                     /translation="MGSMAFHKSRLFLTFGDASEIWLSTLSYLTRKNYASGINFLVSL
                     EILDLSETLIKAISLDHSESLFKIKSLDVFNGKVVSEASKQARAACYISFTKFLYRLT
                     KGYIKPAIPLKDFGNTTFFKIRDKIKTESISKQEWTVFFEALRIVNYRDYLIGKLIVQ
                     GIRKLDEILSLRTDDLFFASNQISFRIKKRQNKETKILITFPISLMEELQKYTCGRNG
                     RVFVSKIGIPVTTSQVAHNFRLAEFHSAMKIKITPRVLRASALIHLKQIGLKDEEIMR
                     ISCLSSRQSVCSYCSGEEVIPLVQTPTIL"
     misc_feature    177..977
                     /locus_tag="PSW4_1"
                     /note="Integrase [DNA replication, recombination, and
                     repair]; Region: XerC; COG0582"
                     /db_xref="CDD:223655"
     misc_feature    570..995
                     /locus_tag="PSW4_1"
                     /note="DNA breaking-rejoining enzymes,
                     intergrase/recombinases, C-terminal catalytic domain. The
                     tyrosine recombinase/integrase family share the same
                     catalytic domain containing six conserved active site
                     residues. The best-studied members of this diverse
                     family...; Region: INT_REC_C; cd01182"
                     /db_xref="CDD:238587"
     misc_feature    order(651..653,924..926,933..935)
                     /locus_tag="PSW4_1"
                     /note="active site"
                     /db_xref="CDD:238587"
     misc_feature    order(651..653,933..935)
                     /locus_tag="PSW4_1"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:238587"
     misc_feature    order(651..653,729..731,924..926,933..935)
                     /locus_tag="PSW4_1"
                     /note="Int/Topo IB signature motif; other site"
                     /db_xref="CDD:238587"
     misc_feature    order(651..653,657..659,729..731,921..926)
                     /locus_tag="PSW4_1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238587"
     gene            complement(1133..2125)
                     /locus_tag="PSW4_2"
                     /db_xref="GeneID:7803135"
     CDS             complement(1133..2125)
                     /locus_tag="PSW4_2"
                     /codon_start=1
                     /transl_table=11
                     /product="putative virulence plasmid integrase"
                     /protein_id="YP_002842023.1"
                     /db_xref="GI:228292902"
                     /db_xref="GeneID:7803135"
                     /translation="MGKGILSLQQEMSLEYSEKSYQEVLKIRQESYWKRMKSFSLFEV
                     IMHWTASLNKHTCRSYRGSFLSLEKIGLLSLDMNLQEFSLLNHNLILDAIKKVSSAKT
                     SWTEGTKQVRAASYISLTRFLNRMTQGIVAIAQPSKQENSRTFFKTREIVKTDAMNSL
                     QTASFLKELKKINARDWLIAQTMLQGGKRSSEVLSLEISQICFQQATISFSQLKNRQT
                     EKRIIITYPQKFMHFLQEYIGQRRGFVFVTRSGKMVGLRQIARTFSQAGLQAAIPFKI
                     TPHVLRATAVTEYKRLGCSDSDIMKVTGHATAKMIFAYDKSSREDNASKKMALI"
     misc_feature    complement(1178..1645)
                     /locus_tag="PSW4_2"
                     /note="DNA breaking-rejoining enzymes,
                     intergrase/recombinases, C-terminal catalytic domain. The
                     tyrosine recombinase/integrase family share the same
                     catalytic domain containing six conserved active site
                     residues. The best-studied members of this diverse
                     family...; Region: INT_REC_C; cd01182"
                     /db_xref="CDD:238587"
     misc_feature    complement(order(1184..1186,1211..1213,1280..1282,
                     1289..1291,1559..1561))
                     /locus_tag="PSW4_2"
                     /note="active site"
                     /db_xref="CDD:238587"
     misc_feature    complement(order(1184..1186,1280..1282,1559..1561))
                     /locus_tag="PSW4_2"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:238587"
     misc_feature    complement(order(1184..1186,1289..1294,1484..1486,
                     1556..1561))
                     /locus_tag="PSW4_2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238587"
     misc_feature    complement(order(1184..1186,1211..1213,1280..1282,
                     1289..1291,1484..1486,1559..1561))
                     /locus_tag="PSW4_2"
                     /note="Int/Topo IB signature motif; other site"
                     /db_xref="CDD:238587"
     gene            2224..3579
                     /locus_tag="PSW4_3"
                     /db_xref="GeneID:7803136"
     CDS             2224..3579
                     /locus_tag="PSW4_3"
                     /codon_start=1
                     /transl_table=11
                     /product="putative helicase, DnaB family"
                     /protein_id="YP_002842024.1"
                     /db_xref="GI:228292903"
                     /db_xref="GeneID:7803136"
                     /translation="MKTRSEIENRMQDIEYALLGKALIFEDSTEYILRQLANYEFKCS
                     HHKNIFIVFKYLKDNGLPITVDSAWEELLRRRIKDMDKSYLGLMLHDALSNDKLRSVS
                     HTVFLDDLSVCSAEENLSNFIFRSFNEYNENPLRRSPFLLLERIKGRLDSAIAKTFSI
                     RSARGRSIYDIFSQSEIGVLARIKKRRVAFSENQNSFFDGFPTGYKDIDDKGVILAKG
                     NFVIIAARPSIGKTALAIDMAINLAVTQQRRVGFLSLEMSAGQIVERIIANLTGISGE
                     KLQRGDLSKEELFRVEEAGETVRESHFYICSDSQYKLNLIANQIRLLRKEDRVDVIFI
                     DYLQLINSSVGENRQNEIADISRTLRGLASELNIPIVCLSQLSRKVEDRANKVPMLSD
                     LRDSGQIEQDADVILFINRKESSSNCEITVGKNRHGSVFSSVLHFDPKISKFSAIKKV
                     W"
     misc_feature    2242..2505
                     /locus_tag="PSW4_3"
                     /note="DnaB-like helicase N terminal domain; Region: DnaB;
                     pfam00772"
                     /db_xref="CDD:216111"
     misc_feature    2821..3570
                     /locus_tag="PSW4_3"
                     /note="DnaB-like helicase C terminal domain; Region:
                     DnaB_C; pfam03796"
                     /db_xref="CDD:217733"
     misc_feature    2839..3540
                     /locus_tag="PSW4_3"
                     /note="DnaB helicase C terminal domain. The hexameric
                     helicase DnaB unwinds the DNA duplex at the  chromosome
                     replication fork. Although the mechanism by which DnaB
                     both couples ATP hydrolysis to translocation along DNA and
                     denatures the duplex is unknown, a...; Region: DnaB_C;
                     cd00984"
                     /db_xref="CDD:238484"
     misc_feature    2899..2919
                     /locus_tag="PSW4_3"
                     /note="Walker A motif; other site"
                     /db_xref="CDD:238484"
     misc_feature    order(2914..2919,3226..3228,3346..3348,3454..3456,
                     3499..3501,3532..3534)
                     /locus_tag="PSW4_3"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:238484"
     misc_feature    3217..3228
                     /locus_tag="PSW4_3"
                     /note="Walker B motif; other site"
                     /db_xref="CDD:238484"
     misc_feature    order(3241..3246,3262..3270,3343..3369,3451..3456,
                     3469..3474)
                     /locus_tag="PSW4_3"
                     /note="DNA binding loops [nucleotide binding]"
                     /db_xref="CDD:238484"
     gene            3573..4628
                     /locus_tag="PSW4_4"
                     /db_xref="GeneID:7803137"
     CDS             3573..4628
                     /locus_tag="PSW4_4"
                     /codon_start=1
                     /transl_table=11
                     /product="conserved hypothetical virulence plasmid
                     protein"
                     /protein_id="YP_002842025.1"
                     /db_xref="GI:228292904"
                     /db_xref="GeneID:7803137"
                     /translation="MVNYSNCHFIKSPIHLENQKFGRRPGQSIKISPKLAQNGMVEVI
                     GLDFLSSHYHALAAIQRLLTATNYKGNTKGVVLSRESNSFQFEGWIPRIRFTKTEFLE
                     AYGVKRYKTSRNKYEFSGKEAETALEALYHLGHQPFLIVATRTRWTNGTQIVDRYQTL
                     SPIIRIYEGWEGLTDEENIDIDLTPFNSPPTRKHKGFVVEPCPILVDQIESYFVIKPA
                     NVYQEIKMRFPNASKYAYTFIDWVITAAAKKRRKLTKDNSWPENLLLNVNVKSLAYIL
                     RMNRYICTRNWKKIELAIDKCIEIAIQLGWLSRRKRIEFLDSSKLSKKEILYLNKERF
                     EEITKKSKEQMEQESIN"
     gene            4690..5484
                     /locus_tag="PSW4_5"
                     /db_xref="GeneID:7803138"
     CDS             4690..5484
                     /locus_tag="PSW4_5"
                     /codon_start=1
                     /transl_table=11
                     /product="conserved hypothetical virulence plasmid
                     protein"
                     /protein_id="YP_002842026.1"
                     /db_xref="GI:228292905"
                     /db_xref="GeneID:7803138"
                     /translation="MGNSGFYLYNTENCVFADNIKVGQMTEPLKDQQIILGTTSTPVA
                     AKMTASDGISLTVSNNSSTNASITIGLDAEKAYQLILEKLGDQILDGIADTIVDSTVQ
                     DILDKIKTDPSLGLLKAFNNFPITNKIQCNGLFTPSNIETLLGGTEIGKFTVTPKSSG
                     SMFLVSADIIASRMEGGVVLALVREGDSKPCAISYGYSSGIPNLCSLRTSITNTGLTP
                     TTYSLRVGGLESGVVWVNALSNGNDILGITNTSNVSFLEVIPQTNA"
     misc_feature    4690..5481
                     /locus_tag="PSW4_5"
                     /note="Chlamydia virulence protein PGP3-D; Region:
                     Chlam_vir; pfam05475"
                     /db_xref="CDD:147581"
     gene            5554..5862
                     /locus_tag="PSW4_6"
                     /db_xref="GeneID:7803139"
     CDS             5554..5862
                     /locus_tag="PSW4_6"
                     /codon_start=1
                     /transl_table=11
                     /product="conserved hypothetical virulence plasmid
                     protein"
                     /protein_id="YP_002842027.1"
                     /db_xref="GI:228292906"
                     /db_xref="GeneID:7803139"
                     /translation="MQNKRKVRDDFIKIVKDVKKDFPELDLKIRVNKEKVTFLNSPLE
                     LYHKSVSLILGLLQQIENSLGLFPDSPVLEKLEDNSLKLKKALIMLILSRKDMFSKAE
                     "
     gene            5890..6684
                     /locus_tag="PSW4_7"
                     /db_xref="GeneID:7803140"
     CDS             5890..6684
                     /locus_tag="PSW4_7"
                     /codon_start=1
                     /transl_table=11
                     /product="putative plasmid partitioning protein, ParA
                     family"
                     /protein_id="YP_002842028.1"
                     /db_xref="GI:228292907"
                     /db_xref="GeneID:7803140"
                     /translation="MHTLVFCSFKGGTGKTTLSLNVGCNLAQFLGKKVLLADLDPQSN
                     LSSGLGASVRSDQKGLHDIVYTSNDLKSIICETKKDSVDLIPASFSSEQFRELDIHRG
                     PSNNLKLFLNEYCAPFYDICIIDTPPSLGGLTKEAFVAGDKLIACLTPEPFSILGLQK
                     IREFLSSVGKPEEEHILGIALSFWDDRNSTNQMYIDIIESIYKNKLFSTKIRRDISLS
                     RSLLKEDSVANVYPNSRAAEDILKLTHEIANILHIEYERDYSQRTT"
     misc_feature    5890..6657
                     /locus_tag="PSW4_7"
                     /note="ATPases involved in chromosome partitioning [Cell
                     division and chromosome partitioning]; Region: Soj;
                     COG1192"
                     /db_xref="CDD:224113"
     misc_feature    5896..>6015
                     /locus_tag="PSW4_7"
                     /note="ParA and ParB of Caulobacter crescentus belong to a
                     conserved family of bacterial proteins implicated in
                     chromosome segregation. ParB binds to DNA sequences
                     adjacent to the origin of replication and localizes to
                     opposite cell poles shortly following the...; Region:
                     ParA; cd02042"
                     /db_xref="CDD:238997"
     misc_feature    5917..5937
                     /locus_tag="PSW4_7"
                     /note="P-loop; other site"
                     /db_xref="CDD:238997"
     misc_feature    5935..5937
                     /locus_tag="PSW4_7"
                     /note="Magnesium ion binding site [ion binding]; other
                     site"
                     /db_xref="CDD:238997"
     misc_feature    <6244..6384
                     /locus_tag="PSW4_7"
                     /note="ParA and ParB of Caulobacter crescentus belong to a
                     conserved family of bacterial proteins implicated in
                     chromosome segregation. ParB binds to DNA sequences
                     adjacent to the origin of replication and localizes to
                     opposite cell poles shortly following the...; Region:
                     ParA; cd02042"
                     /db_xref="CDD:238997"
     misc_feature    6262..6264
                     /locus_tag="PSW4_7"
                     /note="Magnesium ion binding site [ion binding]; other
                     site"
                     /db_xref="CDD:238997"
     gene            6681..7424
                     /locus_tag="PSW4_8"
                     /db_xref="GeneID:7803141"
     CDS             6681..7424
                     /locus_tag="PSW4_8"
                     /codon_start=1
                     /transl_table=11
                     /product="conserved hypothetical virulence plasmid
                     protein"
                     /protein_id="YP_002842029.1"
                     /db_xref="GI:228292908"
                     /db_xref="GeneID:7803141"
                     /translation="MNKLKKEADVFFKKNQTAASLDFKKTLPSIELFSATLNSEESQS
                     LDRLFLSESQNYSDEEFYQEDILAVKLLTGQIKSIQKQHVLLLGEKIYNARKILSKDH
                     FSSTTFSSWIELVFRTKSSAYNALAYYELFINLPNQTLQKEFQSIPYKSAYILAARKG
                     DLKTKVDVIGKVCGMSNSSAIRVLDQFLPSSRNKDVRETIDKSDSEKNRQLSDFLIEI
                     LRIMCSGVSLSSYNENLLQQLFELFKQKS"
     misc_feature    6681..7373
                     /locus_tag="PSW4_8"
                     /note="Uncharacterized protein family (UPF0137); Region:
                     UPF0137; pfam03677"
                     /db_xref="CDD:146355"
ORIGIN      
        1 tttgcaactc ttggtggtag actttgcaac tcttggtggt agactttgca actcttggtg
       61 gtagactttg caactcttgg tggtagactt ggtcataatg gacttttgtt aaaaaatttc
      121 ttaaaatctt agagctccga ttttgaatag ctttggttaa gaaaatgggc tcgatggctt
      181 tccataaaag tagattgttt ttaacttttg gggacgcgtc ggaaatttgg ttatctactt
      241 tatcttatct aactagaaaa aattatgcgt ctgggattaa ctttcttgtt tctttagaga
      301 ttctggattt atcggaaacc ttgataaagg ctatttctct tgaccacagc gaatctttgt
      361 ttaaaatcaa gtctctagat gtttttaatg gaaaagttgt ttcagaggca tctaaacagg
      421 ctagagcggc atgctacata tctttcacaa agtttttgta tagattgacc aagggatata
      481 ttaaacccgc tattccattg aaagattttg gaaacactac attttttaaa atccgagaca
      541 aaatcaaaac agaatcgatt tctaagcagg aatggacagt tttttttgaa gcgctccgga
      601 tagtgaatta tagagactat ttaatcggta aattgattgt acaagggatc cgtaagttag
      661 acgaaatttt gtctttgcgc acagacgatc tattttttgc atccaatcag atttcctttc
      721 gcattaaaaa aagacagaat aaagaaacca aaattctaat cacatttcct atcagcttaa
      781 tggaagagtt gcaaaaatac acttgtggga gaaatgggag agtatttgtt tctaaaatag
      841 ggattcctgt aacaacaagt caggttgcgc ataattttag gcttgcagag ttccatagtg
      901 ctatgaaaat aaaaattact cccagagtac ttcgtgcaag cgctttgatt catttaaagc
      961 aaataggatt aaaagatgag gaaatcatgc gtatttcctg tctttcatcg agacaaagtg
     1021 tgtgttctta ttgttctggg gaagaggtaa ttcctctagt acaaacaccc acaatattgt
     1081 gatataatta aaattatatt catattctgt tgccagaaaa aacaccttta ggctatatta
     1141 gagccatctt ctttgaagcg ttgtcttctc gagaagattt atcgtacgca aatatcatct
     1201 ttgcggttgc gtgtcctgtg accttcatta tgtcggagtc tgagcaccct aggcgtttgt
     1261 actccgtcac agcggttgct cgaagcacgt gcggggttat tttaaaaggg attgcagctt
     1321 gtagtcctgc ttgagagaac gtgcgggcga tttgccttaa ccccaccatt tttccggagc
     1381 gagttacgaa gacaaaacct cttcgttgac cgatgtactc ttgtagaaag tgcataaact
     1441 tctgaggata agttataata atcctctttt ctgtctgacg gttcttaagc tgggagaaag
     1501 aaatggtagc ttgttggaaa caaatctgac taatctccaa gcttaagact tcagaggagc
     1561 gtttacctcc ttggagcatt gtctgggcga tcaaccaatc ccgggcattg atttttttta
     1621 gctcttttag gaaggatgct gtttgcaaac tgttcatcgc atccgttttt actatttccc
     1681 tggttttaaa aaatgttcga ctattttctt gtttagaagg ttgcgctata gcgactattc
     1741 cttgagtcat cctgtttagg aatcttgtta aggaaatata gcttgctgct cgaacttgtt
     1801 tagtaccttc ggtccaagaa gtcttggcag aggaaacttt tttaatcgca tctaggatta
     1861 gattatgatt taaaagggaa aactcttgca gattcatatc caaggacaat agaccaatct
     1921 tttctaaaga caaaaaagat cctcgatatg atctacaagt atgtttgttg agtgatgcgg
     1981 tccaatgcat aataacttcg aataaggaga agcttttcat gcgtttccaa taggattctt
     2041 ggcgaatttt taaaacttcc tgataagact tttcactata ttctaacgac atttcttgct
     2101 gcaaagataa aatcccttta cccatgaaat ccctcgtgat ataacctatc cgtaaaatgt
     2161 cctgattagt gaaataatca ggttgttaac aggatagcac gctcggtatt tttttatata
     2221 aacatgaaaa ctcgttccga aatagaaaat cgcatgcaag atatcgagta tgcgttgtta
     2281 ggtaaagctc tgatatttga agactctact gagtatattc tgaggcagct tgctaattat
     2341 gagtttaagt gttctcatca taaaaacata ttcatagtat ttaaatactt aaaagacaat
     2401 ggattaccta taactgtaga ctcggcttgg gaagagcttt tgcggcgtcg tatcaaagat
     2461 atggacaaat cgtatctcgg gttaatgttg catgatgctt tatcaaatga caagcttaga
     2521 tccgtttctc atacggtttt cctcgatgat ttgagcgtgt gtagcgctga agaaaatttg
     2581 agtaatttca ttttccgctc gtttaatgag tacaatgaaa atccattgcg tagatctccg
     2641 tttctattgc ttgagcgtat aaagggaagg cttgatagtg ctatagcaaa gactttttct
     2701 attcgcagcg ctagaggccg gtctatttat gatatattct cacagtcaga aattggagtg
     2761 ctggctcgta taaaaaaaag acgagtagcg ttctctgaga atcaaaattc tttctttgat
     2821 ggcttcccaa caggatacaa ggatattgat gataaaggag ttatcttagc taaaggtaat
     2881 ttcgtgatta tagcagctag accatctata gggaaaacag ctttagctat agacatggcg
     2941 ataaatcttg cggttactca acagcgtaga gttggtttcc tatctctaga aatgagcgca
     3001 ggtcaaattg ttgagcggat tattgctaat ttaacaggaa tatctggtga aaaattacaa
     3061 agaggggatc tctctaaaga agaattattc cgagtagaag aagctggaga aacggttaga
     3121 gaatcacatt tttatatctg cagtgatagt cagtataagc ttaacttaat cgcgaatcag
     3181 atccggttgc tgagaaaaga agatcgagta gacgtaatat ttatcgatta cttgcagttg
     3241 atcaactcat cggttggaga aaatcgtcaa aatgaaatag cagatatatc tagaacctta
     3301 agaggtttag cctcagagct aaacattcct atagtttgtt tatcccaact atctagaaaa
     3361 gttgaggata gagcaaataa agttcccatg ctttcagatt tgcgagacag cggtcaaata
     3421 gagcaagacg cagatgtgat tttgtttatc aataggaagg aatcgtcttc taattgtgag
     3481 ataactgttg ggaaaaatag acatggatcg gttttctctt cggtattaca tttcgatcca
     3541 aaaattagta aattctccgc tattaaaaaa gtatggtaaa ttatagtaac tgccacttca
     3601 tcaaaagtcc tatccacctt gaaaatcaga agtttggaag aagacctggt caatctatta
     3661 agatatctcc caaattggct caaaatggga tggtagaagt tataggtctt gattttcttt
     3721 catctcatta ccatgcatta gcagctatcc aaagattact gaccgcaacg aattacaagg
     3781 ggaacacaaa aggggttgtt ttatccagag aatcaaatag ttttcaattt gaaggatgga
     3841 taccaagaat ccgttttaca aaaactgaat tcttagaggc ttatggagtt aagcggtata
     3901 aaacatccag aaataagtat gagtttagtg gaaaagaagc tgaaactgct ttagaagcct
     3961 tataccattt aggacatcaa ccgtttttaa tagtggcaac tagaactcga tggactaatg
     4021 gaacacaaat agtagaccgt taccaaactc tttctccgat cattaggatt tacgaaggat
     4081 gggaaggttt aactgacgaa gaaaatatag atatagactt aacacctttt aattcaccac
     4141 ctacacggaa acataaaggg ttcgttgtag agccatgtcc tatcttggta gatcaaatag
     4201 aatcctactt tgtaatcaag cctgcaaatg tataccaaga aataaaaatg cgtttcccaa
     4261 atgcatcaaa gtatgcttac acatttatcg actgggtgat tacagcagct gcgaaaaaga
     4321 gacgaaaatt aactaaggat aattcttggc cagaaaactt gttattaaac gttaacgtta
     4381 aaagtcttgc atatatttta aggatgaatc ggtacatctg tacaaggaac tggaaaaaaa
     4441 tcgagttagc tatcgataaa tgtatagaaa tcgccattca gcttggctgg ttatctagaa
     4501 gaaaacgcat tgaatttctg gattcttcta aactctctaa aaaagaaatt ctatatctaa
     4561 ataaagagcg ctttgaagaa ataactaaga aatctaaaga acaaatggaa caagaatcta
     4621 ttaattaata gcaagcttga aactaaaaac ctaatttatt taaagctcaa aataaaaaag
     4681 agttttaaaa tgggaaattc tggtttttat ttgtataaca ctgaaaactg cgtctttgct
     4741 gataatatca aagttgggca aatgacagag ccgctcaagg accagcaaat aatccttggg
     4801 acaacatcaa cacctgtcgc agccaaaatg acagcttctg atggaatatc tttaacagtc
     4861 tccaataatt catcaaccaa tgcttctatt acaattggtt tggatgcgga aaaagcttac
     4921 cagcttattc tagaaaagtt gggagatcaa attcttgatg gaattgctga tactattgtt
     4981 gatagtacag tccaagatat tttagacaaa atcaaaacag acccttctct aggtttgttg
     5041 aaagctttta acaactttcc aatcactaat aaaattcaat gcaacgggtt attcactccc
     5101 agtaacattg aaactttatt aggaggaact gaaataggaa aattcacagt cacacccaaa
     5161 agctctggga gcatgttctt agtctcagca gatattattg catcaagaat ggaaggcggc
     5221 gttgttctag ctttggtacg agaaggtgat tctaagccct gcgcgattag ttatggatac
     5281 tcatcaggca ttcctaattt atgtagtcta agaaccagta ttactaatac aggattgact
     5341 ccgacaacgt attcattacg tgtaggcggt ttagaaagcg gtgtggtatg ggttaatgcc
     5401 ctttctaatg gcaatgatat tttaggaata acaaatactt ctaatgtatc ttttttagag
     5461 gtaatacctc aaacaaacgc ttaaacaatt tttattggat ttttcttata ggttttatat
     5521 ttagagaaaa cagttcgaat tacggggttt gttatgcaaa ataaaagaaa agtgagggac
     5581 gattttatta aaattgttaa agatgtgaaa aaagatttcc ccgaattaga cctaaaaata
     5641 cgagtaaaca aggaaaaagt aactttctta aattctccct tagaactcta ccataaaagt
     5701 gtctcactaa ttctaggact gcttcaacaa atagaaaact ctttaggatt attcccagac
     5761 tctcctgttc ttgaaaaatt agaggataac agtttaaagc taaaaaaggc tttgattatg
     5821 cttatcttgt ctagaaaaga catgttttcc aaggctgaat agacaactta ctctaacgtt
     5881 ggagttgatt tgcacacctt agttttttgc tcttttaagg gaggaactgg aaaaacaaca
     5941 ctttctctaa acgtgggatg caacttggcc caatttttag ggaaaaaagt gttacttgct
     6001 gacctagacc cgcaatccaa tttatcttct ggattggggg ctagtgtcag aagtgaccaa
     6061 aaaggcttgc acgacatagt atacacatca aacgatttaa aatcaatcat ttgcgaaaca
     6121 aaaaaagata gtgtggacct aattcctgca tcattttcat ccgaacagtt tagagaattg
     6181 gatattcata gaggacctag taacaactta aagttatttc tgaatgagta ctgcgctcct
     6241 ttttatgaca tctgcataat agacactcca cctagcctag gagggttaac gaaagaagct
     6301 tttgttgcag gagacaaatt aattgcttgt ttaactccag aacctttttc tattctaggg
     6361 ttacaaaaga tacgtgaatt cttaagttcg gtcggaaaac ctgaagaaga acacattctt
     6421 ggaatagctt tgtctttttg ggatgatcgt aactcgacta accaaatgta tatagacatt
     6481 atcgagtcta tttacaaaaa caagcttttt tcaacaaaaa ttcgtcgaga tatttctctc
     6541 agccgttctc ttcttaaaga agattctgta gctaatgtct atccaaattc tagggccgca
     6601 gaagatattc tgaagttaac gcatgaaata gcaaatattt tgcatatcga atatgaacga
     6661 gattactctc agaggacaac gtgaacaaac taaaaaaaga agcggatgtc ttttttaaaa
     6721 aaaatcaaac tgccgcttct ctagatttta agaagacgct tccctccatt gaactattct
     6781 cagcaacttt gaattctgag gaaagtcaga gtttggatcg attattttta tcagagtccc
     6841 aaaactattc ggatgaagaa ttttatcaag aagacatcct agcggtaaaa ctgcttactg
     6901 gtcagataaa atccatacag aagcaacacg tacttctttt aggagaaaaa atctataatg
     6961 ctagaaaaat cctgagtaag gatcacttct cctcaacaac tttttcatct tggatagagt
     7021 tagtttttag aactaagtct tctgcttaca atgctcttgc atattacgag ctttttataa
     7081 acctccccaa ccaaactcta caaaaagagt ttcaatcgat cccctataaa tccgcatata
     7141 ttttggccgc tagaaaaggc gatttaaaaa ccaaggtcga tgtgataggg aaagtatgtg
     7201 gaatgtcgaa ctcatcggcg ataagggtgt tggatcaatt tcttccttca tctagaaaca
     7261 aagacgttag agaaacgata gataagtctg attcagagaa gaatcgccaa ttatctgatt
     7321 tcttaataga gatacttcgc atcatgtgtt ccggagtttc tttgtcctcc tataacgaaa
     7381 atcttctaca acagcttttt gaacttttta agcaaaagag ctgatcctcc gtcagctcat
     7441 atatatatat ctattatata tatatattta gggatttgat ttcacgagag aga
//
