LOCUS       NC_015701              19059 bp    DNA     circular CON 08-JUN-2013
DEFINITION  Lactobacillus reuteri SD2112 plasmid pLR584, complete sequence.
ACCESSION   NC_015701
VERSION     NC_015701.1  GI:338204606
DBLINK      Project: 55357
            BioProject: PRJNA55357
KEYWORDS    .
SOURCE      Lactobacillus reuteri SD2112
  ORGANISM  Lactobacillus reuteri SD2112
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
            Lactobacillus.
REFERENCE   1  (bases 1 to 19059)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (23-JUN-2011) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   2  (bases 1 to 19059)
  AUTHORS   Muzny,D., Qin,X., Buhay,C., Dugan-Rocha,S., Ding,Y., Chen,G.,
            Hawes,A., Holder,M., Jhangiani,S., Johnson,A., Khan,Z., Li,Z.,
            Liu,W., Liu,X., Perez,L., Shen,H., Wang,Q., Watt,J., Xi,L., Xin,Y.,
            Zhou,J., Deng,J., Jiang,H., Liu,Y., Qu,J., Song,X.-Z., Zhang,L.,
            Villasana,D., Johnson,A., Liu,J., Liyanage,D., Lorensuhewa,L.,
            Robinson,T., Song,A., Song,B.-B., Dinh,H., Thornton,R., Coyle,M.,
            Francisco,L., Jackson,L., Javaid,M., Korchina,V., Kovar,C.,
            Mata,R., Mathew,T., Ngo,R., Nguyen,L., Nguyen,N., Okwuonu,G.,
            Ongeri,F., Pham,C., Simmons,D., Wilczek-Boney,K., Hale,W.,
            Jakkamsetti,A., Pham,P., Ruth,R., San Lucas,F., Warren,J.,
            Zhang,J., Zhao,Z., Zhou,C., Zhu,D., Lee,S., Bess,C.,
            Blankenburg,K., Forbes,L., Fu,Q., Gubbala,S., Hirani,K.,
            Jayaseelan,J.C., Lara,F., Munidasa,M., Palculict,T., Patil,S.,
            Pu,L.-L., Saada,N., Tang,L., Weissenberger,G., Zhu,Y., Hemphill,L.,
            Shang,Y., Youmans,B., Ayvaz,T., Ross,M., Santibanez,J., Aqrawi,P.,
            Gross,S., Joshi,V., Fowler,G., Nazareth,L., Reid,J., Worley,K.,
            Petrosino,J., Highlander,S. and Gibbs,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUN-2011) Human Genome Sequencing Center, Baylor
            College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to CP002847.
            Lactobacillus reuteri SD2112
            
             Strain source, body site: Gastrointestinal tract
            
             Inquiries should be directed to microbe@hgsc.bcm.tmc.edu
            
             This is a reference genome for the Human Microbiome Project. This
            project is co-owned with the Human Microbiome Project DACC.  Source
            DNA provided by Versalovic, J. (Department of Pathology, Texas
            Children's Hospital, 1102 Bates Avenue, Suite 830, Feigin Center,
            Houston, TX, 77030, USA).  Funded by by 'Genomes and Genetics at
            BCM-HGSC' (U54 HG003273).
            
            ##Genome-Assembly-Data-START##
            Finishing Goal           :: Finished
            Current Finishing Status :: Finished
            Assembly Method          :: Newbler Assembler v. 2.3.10192009
            Genome Coverage          :: 63x
            Sequencing Technology    :: 454
            ##Genome-Assembly-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..19059
                     /organism="Lactobacillus reuteri SD2112"
                     /mol_type="genomic DNA"
                     /strain="SD2112"
                     /culture_collection="ATCC:55730"
                     /db_xref="HMP:00538"
                     /db_xref="HOMD:tax_818"
                     /db_xref="taxon:491077"
                     /plasmid="pLR584"
     gene            361..720
                     /locus_tag="HMPREF0538_22286"
                     /db_xref="GeneID:10865945"
     CDS             361..720
                     /locus_tag="HMPREF0538_22286"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_004650788.1"
                     /db_xref="GI:338204607"
                     /db_xref="GeneID:10865945"
                     /translation="MFDYTTATRDQKEEFLQDKILICLQATKQPMTNAQIREYLLKHV
                     DELPANVTKLTTSKKGSVYSDFQIRVNMSITSLYKGGLVDHPKRGVTELTQLGKSINL
                     NTGRKHMHKLIVEGWQK"
     misc_feature    418..660
                     /locus_tag="HMPREF0538_22286"
                     /note="Mrr N-terminal domain; Region: Mrr_N; pfam14338"
                     /db_xref="CDD:222692"
     gene            717..1304
                     /locus_tag="HMPREF0538_22287"
                     /db_xref="GeneID:10865942"
     CDS             717..1304
                     /locus_tag="HMPREF0538_22287"
                     /codon_start=1
                     /transl_table=11
                     /product="integrase"
                     /protein_id="YP_004650789.1"
                     /db_xref="GI:338204608"
                     /db_xref="GeneID:10865942"
                     /translation="MKQLVLPIKDSNILHEVQDTLLNNFRYGRRNYTIFQVGKATLLR
                     VSDVLALRRNEIFNDDGTIKKNAYIRDKKTDKPNTLYLKPVNQDLIDYLQWLNENKIQ
                     SDWLFPSIKHPDRHITEKQFYKIMAKTGDLLGINYLGTHTMRKTGAYRVYTQTNYNIG
                     LVMSLLNHSSEAMTLKYLGLDQVSREQMLDKVSFD"
     misc_feature    729..1298
                     /locus_tag="HMPREF0538_22287"
                     /note="DNA breaking-rejoining enzymes, C-terminal
                     catalytic domain. The DNA breaking-rejoining enzyme
                     superfamily includes type IB topoisomerases and tyrosine
                     recombinases that share the same fold in their catalytic
                     domain containing six conserved active site...; Region:
                     DNA_BRE_C; cl00213"
                     /db_xref="CDD:241691"
     misc_feature    <777..1256
                     /locus_tag="HMPREF0538_22287"
                     /note="Integrase [DNA replication, recombination, and
                     repair]; Region: XerC; COG0582"
                     /db_xref="CDD:223655"
     misc_feature    order(846..848,1137..1139,1146..1148,1218..1220,
                     1245..1247)
                     /locus_tag="HMPREF0538_22287"
                     /note="active site"
                     /db_xref="CDD:238231"
     misc_feature    order(846..851,933..935,1131..1139,1245..1247)
                     /locus_tag="HMPREF0538_22287"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238231"
     misc_feature    order(846..848,933..935,1137..1139,1146..1148,1218..1220,
                     1245..1247)
                     /locus_tag="HMPREF0538_22287"
                     /note="Int/Topo IB signature motif; other site"
                     /db_xref="CDD:238231"
     gene            complement(1770..1846)
                     /locus_tag="HMPREF0538_nc22286"
                     /db_xref="GeneID:10865943"
     ncRNA           complement(1770..1846)
                     /locus_tag="HMPREF0538_nc22286"
                     /ncRNA_class="autocatalytically_spliced_intron"
                     /product="Group II catalytic intron"
                     /db_xref="GeneID:10865943"
     gene            complement(1854..3236)
                     /locus_tag="HMPREF0538_22289"
                     /db_xref="GeneID:10865944"
     CDS             complement(1854..3236)
                     /locus_tag="HMPREF0538_22289"
                     /note="COG: COG3344"
                     /codon_start=1
                     /transl_table=11
                     /product="RNA-directed DNA polymerase"
                     /protein_id="YP_004650790.1"
                     /db_xref="GI:338204609"
                     /db_xref="GeneID:10865944"
                     /translation="MRQSQKTEQQADRLSRIGLENRKYTRARSTDYGEGKGMSVTIQD
                     LVLDRNNLNQAYLRVKRNKGAAGIDDMTVNDLLPYLRENKTELIASLREGKYKPAPVK
                     RVEIPKPNGGVRKLGIPTVVDRMVQQAVAQILTPIFERVFSDNSFGFRPHRGAHDAIA
                     KVVDLYNQGYRRVVDLDLKAYFDNVNHDLMIKYLQQYIDDPWTLRLIRKFLTSGVLDH
                     GLFAKSEKGTPQGGPLSPILANIYLNELDKELTRRGHHFVRYADDCNIYVKSQRAGER
                     VMRSITQFLEKRLKVKVNPDKTKVGSPLRLKFLGFSLGVDHNGAYARPAKQSQQRVKK
                     ALRLLTKRNRGISLTRMFEEIHRKMRGWLQYYSIGKLTDFIQRLDKWLRARIRQYIWK
                     QWKKLKTKVTNLQKLGLSQRDAYVFASTRKGYWRTAHSKTLSYSLTNRKLEQLGLMNM
                     SKTLQSIQCD"
     misc_feature    complement(2298..2933)
                     /locus_tag="HMPREF0538_22289"
                     /note="RT_G2_intron: Reverse transcriptases (RTs) with
                     group II intron origin. RT transcribes DNA using RNA as
                     template. Proteins in this subfamily are found in
                     bacterial and mitochondrial group II introns. Their most
                     probable ancestor was a retrotransposable...; Region:
                     RT_G2_intron; cd01651"
                     /db_xref="CDD:238828"
     misc_feature    complement(2298..2921)
                     /locus_tag="HMPREF0538_22289"
                     /note="Reverse transcriptase (RNA-dependent DNA
                     polymerase); Region: RVT_1; pfam00078"
                     /db_xref="CDD:215698"
     misc_feature    complement(order(2307..2312,2448..2453,2457..2459,
                     2544..2549,2691..2708))
                     /locus_tag="HMPREF0538_22289"
                     /note="putative active site [active]"
                     /db_xref="CDD:238828"
     misc_feature    complement(order(2451..2453,2547..2549,2691..2708))
                     /locus_tag="HMPREF0538_22289"
                     /note="putative NTP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238828"
     misc_feature    complement(2544..2546)
                     /locus_tag="HMPREF0538_22289"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]; other site"
                     /db_xref="CDD:238828"
     misc_feature    complement(2013..2252)
                     /locus_tag="HMPREF0538_22289"
                     /note="Group II intron, maturase-specific domain; Region:
                     GIIM; pfam08388"
                     /db_xref="CDD:219816"
     gene            complement(3795..4190)
                     /locus_tag="HMPREF0538_22290"
                     /db_xref="GeneID:10865946"
     CDS             complement(3795..4190)
                     /locus_tag="HMPREF0538_22290"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_004650791.1"
                     /db_xref="GI:338204610"
                     /db_xref="GeneID:10865946"
                     /translation="MILPAKKYENRDKVKKDAIRARVTKAEKTEIQKWAKGAGEDVSA
                     FLLNGAQSRHYALKKMPINIEDSTDFGNYSSASFGLLIDDLNDALSNIDSCLFENTKE
                     KELYAQSIQWIIQRMKVSGEKYDSEHKND"
     gene            4773..5642
                     /locus_tag="HMPREF0538_22291"
                     /db_xref="GeneID:10865947"
     CDS             4773..5642
                     /locus_tag="HMPREF0538_22291"
                     /codon_start=1
                     /transl_table=11
                     /product="replication rep protein"
                     /protein_id="YP_004650792.1"
                     /db_xref="GI:338204611"
                     /db_xref="GeneID:10865947"
                     /translation="MVLMTVNKVVIKNKADIHPEDTVKYMVTNNYVHERKSLYTNHKA
                     NIIKKGKGNYFNKNTGEKITKVKNSNLKIQNRQSLIRSYVNLRYTIEKYVTGSIYDEM
                     YTLTYEKAQTSFKDLSHDFVTFMKRFKRYVKKNYPKVNLSWIRINEPHKDTINGKPKW
                     HIHLIVIGLPFMKHHILEKLWGHGIVTITSYYKCNIHKVANYFTGFINKNDSDPESKK
                     GRLKYYTSGTDLFSLSRGLHVPKWIQGTDQEIRKKHPGKIINETTIEIRDTNDNSLFN
                     RFAYRDIESNKTK"
     gene            6865..7749
                     /gene="repB"
                     /locus_tag="HMPREF0538_22292"
                     /db_xref="GeneID:10865948"
     CDS             6865..7749
                     /gene="repB"
                     /locus_tag="HMPREF0538_22292"
                     /note="COG: COG1192"
                     /codon_start=1
                     /transl_table=11
                     /product="replication-associated protein RepB"
                     /protein_id="YP_004650793.1"
                     /db_xref="GI:338204612"
                     /db_xref="GeneID:10865948"
                     /translation="MPTVLYGNMKGGVGKTTNSVMTAYQLARKGYKTLVCDLDPQANA
                     TQLLRRTYGLQHGTDLKIEKTMMVALTEENIEPAIVNIMDNLYLLPSSEDFKNYPDFL
                     EMKFMPDKEKILAGNSTTLQSEMAKVKEKRIAYFSKQLAKVHDQYDFIIIDVPPTLSI
                     FTDSAIYATNFVIIVLQTQQRSLDGAETFFEYLQEMYNNYANIDFDIIGVLAVLLKNN
                     AGLDSQILKDARVDFGDDMLFNQIIRHMERLKRYDRTGIAEKGLTKYDMHDTRLHYIY
                     TKLTDEIIARLKDKGALN"
     misc_feature    6871..>6987
                     /gene="repB"
                     /locus_tag="HMPREF0538_22292"
                     /note="ParA and ParB of Caulobacter crescentus belong to a
                     conserved family of bacterial proteins implicated in
                     chromosome segregation. ParB binds to DNA sequences
                     adjacent to the origin of replication and localizes to
                     opposite cell poles shortly following the...; Region:
                     ParA; cd02042"
                     /db_xref="CDD:238997"
     misc_feature    6886..7737
                     /gene="repB"
                     /locus_tag="HMPREF0538_22292"
                     /note="ATPases involved in chromosome partitioning [Cell
                     division and chromosome partitioning]; Region: Soj;
                     COG1192"
                     /db_xref="CDD:224113"
     misc_feature    6892..6912
                     /gene="repB"
                     /locus_tag="HMPREF0538_22292"
                     /note="P-loop; other site"
                     /db_xref="CDD:238997"
     misc_feature    6910..6912
                     /gene="repB"
                     /locus_tag="HMPREF0538_22292"
                     /note="Magnesium ion binding site [ion binding]; other
                     site"
                     /db_xref="CDD:238997"
     misc_feature    <7300..7497
                     /gene="repB"
                     /locus_tag="HMPREF0538_22292"
                     /note="ParA and ParB of Caulobacter crescentus belong to a
                     conserved family of bacterial proteins implicated in
                     chromosome segregation. ParB binds to DNA sequences
                     adjacent to the origin of replication and localizes to
                     opposite cell poles shortly following the...; Region:
                     ParA; cd02042"
                     /db_xref="CDD:238997"
     misc_feature    7321..7323
                     /gene="repB"
                     /locus_tag="HMPREF0538_22292"
                     /note="Magnesium ion binding site [ion binding]; other
                     site"
                     /db_xref="CDD:238997"
     gene            7749..8123
                     /locus_tag="HMPREF0538_22293"
                     /db_xref="GeneID:10865949"
     CDS             7749..8123
                     /locus_tag="HMPREF0538_22293"
                     /codon_start=1
                     /transl_table=11
                     /product="replication-associated protein"
                     /protein_id="YP_004650794.1"
                     /db_xref="GI:338204613"
                     /db_xref="GeneID:10865949"
                     /translation="MAKYQFDKGTKRRSKPRPKPIDKTDISKPKITYNPLTVTDRVEN
                     DLQHKKRSVGRPKTGRKSYKTVRLLTSTVLKINALENALGIKTQDATVDQAVDRVINS
                     LTNDEMRAYKLWLEMFEKKEKE"
     gene            complement(8192..8785)
                     /locus_tag="HMPREF0538_22294"
                     /db_xref="GeneID:10865950"
     CDS             complement(8192..8785)
                     /locus_tag="HMPREF0538_22294"
                     /codon_start=1
                     /transl_table=11
                     /product="resolvase"
                     /protein_id="YP_004650795.1"
                     /db_xref="GI:338204614"
                     /db_xref="GeneID:10865950"
                     /translation="MKHMSMYAYVAGTTNNDINDKGSIACQIDFLKQTNVDYDAYFID
                     TFTGVCQARFQLQKLLMVVKPGDMIDVMDVSNMTSNVRELCCLLDEIEDLQITIFSDE
                     LEMGMSNSREPYYVAKMLCRADMVTMMQRSSNRKKMCQMTHQIDLHRDKSNKREITQQ
                     DYQIYNLLMKSDYRTTQQATGLSRSTLYRLKKRIQKR"
     gene            8928..10934
                     /gene="sthIM"
                     /locus_tag="HMPREF0538_22295"
                     /db_xref="GeneID:10865951"
     CDS             8928..10934
                     /gene="sthIM"
                     /locus_tag="HMPREF0538_22295"
                     /note="COG: COG2189"
                     /codon_start=1
                     /transl_table=11
                     /product="type III restriction-modification system DNA
                     methylase"
                     /protein_id="YP_004650796.1"
                     /db_xref="GI:338204615"
                     /db_xref="GeneID:10865951"
                     /translation="MQIDTRLMEQVKDVLQQFGTKYITKDGSLKRNAVISDLDKYDKD
                     LMVALLANNLIKDEYTEQIADTTVFKLNHFIEMFEYQEFWGNSFTKYANRIGLTSDDK
                     FISDSDDVVLDFPYKDTVLKAGMTKDDVDKEVGADEPFLNETLAHSEISELFEPKVLV
                     NAKLYDTEGEHKATNFDDNDNLVIKGNNLIALHSIAKKYAGKIKLIYLDPPYNTGSDS
                     FKYNDRFSHATWLTFMKSRLEIAKTLMSDNGVIAIQLDDSEGPYLKVLTDSIFGRDNE
                     LFTQYVLVRYANKTLKSDMDYHKQIEQIHYYKKNSNAEVKPNKDKVPYDYSKFCYEVK
                     TTGKPSSSIMLGDKQVDIFTKDQVEFKKTSGNPEGLKEIWASGTILNGNSSGRFFRDY
                     LSGRYKKDGYGVVYKVYDIGDDGNDYRFFTGPKKAGATKGKYYQGVPLDVKNGKTSQK
                     LLPIPGFIDMAGSFGNDRLEGGVELRNGKKPEKLLKNIIKYFSNKNDYVMDFFAGSGS
                     TLATAMKMSRKFIAIEQINEQIIKINKRLNNVIHGDQTGISKEVNWQGGGSFVYTELM
                     KKNQGFLYDLQKATTIDELNAVYDRMKQGADLDFRVDLNKFENDSERASLPFEDQKKL
                     LIKLLDKNQLYYNEANIDDADVRDLISDSDYRFNKSFYNGKESK"
     misc_feature    9048..9218
                     /gene="sthIM"
                     /locus_tag="HMPREF0538_22295"
                     /note="Type III restriction/modification enzyme
                     methylation subunit; Region: TypeIII_RM_meth; pfam12564"
                     /db_xref="CDD:193081"
     misc_feature    9072..10640
                     /gene="sthIM"
                     /locus_tag="HMPREF0538_22295"
                     /note="Adenine specific DNA methylase Mod [DNA
                     replication, recombination, and repair]; Region: COG2189"
                     /db_xref="CDD:225100"
     misc_feature    9534..>10034
                     /gene="sthIM"
                     /locus_tag="HMPREF0538_22295"
                     /note="DNA methylase; Region: N6_N4_Mtase; pfam01555"
                     /db_xref="CDD:216568"
     misc_feature    <10335..10490
                     /gene="sthIM"
                     /locus_tag="HMPREF0538_22295"
                     /note="DNA methylase; Region: N6_N4_Mtase; pfam01555"
                     /db_xref="CDD:216568"
     gene            10934..13567
                     /locus_tag="HMPREF0538_22296"
                     /db_xref="GeneID:10865952"
     CDS             10934..13567
                     /locus_tag="HMPREF0538_22296"
                     /EC_number="3.1.21.5"
                     /note="COG: COG3421"
                     /codon_start=1
                     /transl_table=11
                     /product="type III restriction-modification system
                     restriction subunit"
                     /protein_id="YP_004650797.1"
                     /db_xref="GI:338204616"
                     /db_xref="GeneID:10865952"
                     /translation="MARKKTIPEEKIDLQLLNALNSTSLFSLKSSLEDNPLYITNNLK
                     HKLRNYQMDAVHHLDAVLNMKDADQRNQLMFYMATGSGKTDIMAAIILYMFRAWGYQC
                     FLFTTNTTAVVDKTIDNLVNSASAKYLYNNPLVIDGDHVTIKKVDRYPVNLEKDTIYI
                     KLAGIQQLSNDYYAPRENGITKDSLARHKLVLLADEAHHFNVSTRSKKANREGLSWEH
                     LLDEIRQLNHENKQLEFTATIDLHNPDIYHKYQNKIIAQYDLSHFINDGFSKKVYRLQ
                     ANNSDENKMLNAVLLSQYRKRIAQNMSIPDFKPVILFKSNTIAESRAINETFLTMIDN
                     LSAESLQQFIQNQNRSTQSEALSLAYKYWLNQDFGSTVTELKRDFSKFTTINANDSGS
                     KNILDDESVSRRLNSLESPDNPIRSVFAVAKLSEGWDVLNLFDIVRIGEKNIKPKDTN
                     AEAQLIGRGARYYPFVYHGKKSYTRRFDDRKPEIQLLERLYYHTINDPQYLENLRKSL
                     DAIDLPVNEDTQYKVYTAKVKNSFKKTKAYKHGNIYYNKVIDVPESHYDSIQKYGFDP
                     ETTGPIDMVDAVSERRYDTGADKNDTTSTTLEVAARFSNPQDKALIRTAVSFNNFYRF
                     DSLKKYCPTLTSMREFLTSNEWLGNATIRVKVATGSPALTNEQRLTAVKKYLVRVQTA
                     ISNNFKRSIGTNEFMPIAVNEVIQDYQKRVGDQFGKSALIGPDSMQGKDWYVYDYAIV
                     DTLEKHFIDHINSIMPELTHQYGQAYLLRIDERTTDFKLHDFGENIFHYEGYMPDFIL
                     YLENENFIYQIFLEPKGTPYIERDKWKEKLLERINPDNIKVLGEDEKVKIYGLKFYVE
                     DDGKEDTHGLFQEMRDKNILQ"
     misc_feature    11063..>11284
                     /locus_tag="HMPREF0538_22296"
                     /note="Type III restriction enzyme, res subunit; Region:
                     ResIII; pfam04851"
                     /db_xref="CDD:218292"
     misc_feature    11153..13495
                     /locus_tag="HMPREF0538_22296"
                     /note="Uncharacterized protein conserved in bacteria
                     [Function unknown]; Region: COG3421"
                     /db_xref="CDD:225955"
     misc_feature    11162..11650
                     /locus_tag="HMPREF0538_22296"
                     /note="DEAD-like helicases superfamily. A diverse family
                     of proteins involved in ATP-dependent RNA or DNA
                     unwinding. This domain contains the ATP-binding region;
                     Region: DEXDc; cl17251"
                     /db_xref="CDD:247805"
     misc_feature    11171..11185
                     /locus_tag="HMPREF0538_22296"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:238005"
     misc_feature    11516..11527
                     /locus_tag="HMPREF0538_22296"
                     /note="putative Mg++ binding site [ion binding]; other
                     site"
                     /db_xref="CDD:238005"
     gene            complement(14085..14381)
                     /locus_tag="HMPREF0538_22297"
                     /db_xref="GeneID:10865953"
     CDS             complement(14085..14381)
                     /locus_tag="HMPREF0538_22297"
                     /codon_start=1
                     /transl_table=11
                     /product="lysophospholipase family protein"
                     /protein_id="YP_004650798.1"
                     /db_xref="GI:338204617"
                     /db_xref="GeneID:10865953"
                     /translation="MKILTGSRGDEVHEHLYENGQRRVGHRILKKNTVTNNGEFHPVP
                     GNIVLIPLKGTVKLTTPDQECTIKNGQLAILGPTDSFYLTAIDDVEFVGVVDIK"
     gene            complement(14400..14609)
                     /locus_tag="HMPREF0538_22298"
                     /db_xref="GeneID:10865954"
     CDS             complement(14400..14609)
                     /locus_tag="HMPREF0538_22298"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_004650799.1"
                     /db_xref="GI:338204618"
                     /db_xref="GeneID:10865954"
                     /translation="MTKTYYRNKAKGSETMSQWILIALFLLAHPLMMLFMHKGMHGGS
                     GSMGCCGNNTQQNSNNTEKPRKKVN"
     misc_feature    complement(<14502..>14552)
                     /locus_tag="HMPREF0538_22298"
                     /note="Protein of unknown function (DUF2933); Region:
                     DUF2933; pfam11666"
                     /db_xref="CDD:204706"
     gene            complement(14741..14932)
                     /locus_tag="HMPREF0538_22299"
                     /db_xref="GeneID:10865955"
     CDS             complement(14741..14932)
                     /locus_tag="HMPREF0538_22299"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_004650800.1"
                     /db_xref="GI:338204619"
                     /db_xref="GeneID:10865955"
                     /translation="MTKTYYRNKAKGGETMSQWILVALCLLAHPLMMLFMHKGMHGGS
                     GNNTQQNSNNTEKPRKKVN"
     gene            complement(14940..17237)
                     /gene="atkB"
                     /locus_tag="HMPREF0538_22300"
                     /db_xref="GeneID:10865956"
     CDS             complement(14940..17237)
                     /gene="atkB"
                     /locus_tag="HMPREF0538_22300"
                     /EC_number="3.6.3.4"
                     /note="COG: COG2217"
                     /codon_start=1
                     /transl_table=11
                     /product="copper-exporting ATPase"
                     /protein_id="YP_004650801.1"
                     /db_xref="GI:338204620"
                     /db_xref="GeneID:10865956"
                     /translation="MAWCSAKQKPKYKNLVGKSRAREFPHKELIFRLLTALLRTLIFR
                     GSIIMANKEGHMNMKNMSAKNMENNESNMSHMDHDMTETDHSQMNMNHGDMDMAGADM
                     MMHGGSMMHMGNLKVKFWVSVVLAIPVLLLAPIMGLNVSILSFSSPLIVGIIIVLFDT
                     ALYFYGGMPFLKGAKAEIQNKSPEMMTLVTLGISVSYFYSLYAFIANNFLNPTNHIMD
                     FSFELATLILIMLLGHWIEMNALMGAGNALQKMAALLPKTAHLVTDNGETKEVPVSDL
                     KVGQAFQVRSGESIPADGVITAGESTVNEALVTGESAAVTKNVGDKVIGGTTNNNGTL
                     TVKISGTGDSSYLSQVMKMVQNAQQAKSKAEDKADLVAKYLFYAALGVGIIAFFAWLP
                     QGLATAMTIMVTVFVIACPHALGLAIPLVVSRSTTIGAQNGLLVRNRQAIEASQHVSH
                     VLLDKTGTLTEGKFTVNALIPNDGIDETTLLSRLAALEINSTHPLAQAIITEAQAKNI
                     EVVAAEKSQNIPGVGISGNVDGTDYMIVNGNYLTKQGIRFDEAAADKWAAKGNSVSFL
                     LQGTQVQGMVAEGDTIKAGAKELISGLQRRGITPVMLTGDNPKAAEHVANLLGLTEFH
                     AGLLPDDKQKIIADYQAKGNHVIMVGDGVNDAPSLAAADIGIAIGAGTDVAIDSADVV
                     LVKSEPSDILHFLDLAKITNRKMVQNLWWGAGYNVVAIPLAAGVLSFIGIILDPAVGA
                     AVMAMSTIIVAINAMGLTGEKIKNV"
     misc_feature    complement(15021..16742)
                     /gene="atkB"
                     /locus_tag="HMPREF0538_22300"
                     /note="copper-(or silver)-translocating P-type ATPase;
                     Region: ATPase-IB1_Cu; TIGR01511"
                     /db_xref="CDD:233445"
     misc_feature    complement(15906..16562)
                     /gene="atkB"
                     /locus_tag="HMPREF0538_22300"
                     /note="E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122"
                     /db_xref="CDD:215733"
     misc_feature    complement(15273..15497)
                     /gene="atkB"
                     /locus_tag="HMPREF0538_22300"
                     /note="Haloacid dehalogenase-like hydrolases. The haloacid
                     dehalogenase-like (HAD) superfamily includes L-2-haloacid
                     dehalogenase, epoxide hydrolase, phosphoserine
                     phosphatase, phosphomannomutase, phosphoglycolate
                     phosphatase, P-type ATPase, and many others; Region:
                     HAD_like; cd01427"
                     /db_xref="CDD:119389"
     misc_feature    complement(15426..15428)
                     /gene="atkB"
                     /locus_tag="HMPREF0538_22300"
                     /note="motif II; other site"
                     /db_xref="CDD:119389"
     gene            complement(17344..17775)
                     /gene="copY"
                     /locus_tag="HMPREF0538_22301"
                     /db_xref="GeneID:10865957"
     CDS             complement(17344..17775)
                     /gene="copY"
                     /locus_tag="HMPREF0538_22301"
                     /note="COG: COG3682"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional repressor CopY"
                     /protein_id="YP_004650802.1"
                     /db_xref="GI:338204621"
                     /db_xref="GeneID:10865957"
                     /translation="MKDPKNVTITDSEWMVMRAIWTMGHATSRELIDAMNELEGWSAS
                     TTKTLLHRLIQKQAVAQHGGSRPFTYKPVVGEKESMAAAADDLFDHMCAMRAGSTIAG
                     VIQSRELSRADIANLQAILAEKAKTAPEEVQCNCLPGDQTC"
     misc_feature    complement(17365..17754)
                     /gene="copY"
                     /locus_tag="HMPREF0538_22301"
                     /note="copper transport repressor, CopY/TcrY family;
                     Region: CopY_TcrY; TIGR02698"
                     /db_xref="CDD:131745"
     misc_feature    complement(17407..17751)
                     /gene="copY"
                     /locus_tag="HMPREF0538_22301"
                     /note="Penicillinase repressor; Region: Pencillinase_R;
                     pfam03965"
                     /db_xref="CDD:146546"
     gene            complement(18036..18386)
                     /gene="cadC"
                     /locus_tag="HMPREF0538_22302"
                     /db_xref="GeneID:10865958"
     CDS             complement(18036..18386)
                     /gene="cadC"
                     /locus_tag="HMPREF0538_22302"
                     /note="COG: COG0640"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator CadC"
                     /protein_id="YP_004650803.1"
                     /db_xref="GI:338204622"
                     /db_xref="GeneID:10865958"
                     /translation="MKSKSADITCDQTLVETDKVMKVSEFLGKSRIKKYFYVLSKISD
                     EKKLKIIFSLIAQESLCVCDIAYILGCSIATASHHLRMLYDADILDRQKKGKMVYYFI
                     KDDDLKKILAQLDR"
     misc_feature    complement(18069..18272)
                     /gene="cadC"
                     /locus_tag="HMPREF0538_22302"
                     /note="Arsenical Resistance Operon Repressor and similar
                     prokaryotic, metal regulated homodimeric repressors. ARSR
                     subfamily of helix-turn-helix bacterial transcription
                     regulatory proteins (winged helix topology). Includes
                     several proteins that appear to...; Region: HTH_ARSR;
                     cd00090"
                     /db_xref="CDD:238042"
     misc_feature    complement(order(18126..18128,18216..18218,18225..18230,
                     18240..18245,18252..18254,18261..18263,18267..18272))
                     /gene="cadC"
                     /locus_tag="HMPREF0538_22302"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238042"
     misc_feature    complement(order(18087..18095,18108..18116,18132..18137,
                     18141..18146,18153..18158,18162..18173,18198..18206,
                     18246..18254,18264..18269))
                     /gene="cadC"
                     /locus_tag="HMPREF0538_22302"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:238042"
     misc_feature    complement(order(18195..18197,18204..18206))
                     /gene="cadC"
                     /locus_tag="HMPREF0538_22302"
                     /note="putative Zn2+ binding site [ion binding]; other
                     site"
                     /db_xref="CDD:238042"
     gene            complement(18403..19020)
                     /gene="cadD"
                     /locus_tag="HMPREF0538_22303"
                     /db_xref="GeneID:10865959"
     CDS             complement(18403..19020)
                     /gene="cadD"
                     /locus_tag="HMPREF0538_22303"
                     /note="COG: COG4300"
                     /codon_start=1
                     /transl_table=11
                     /product="cadmium resistance protein CadD"
                     /protein_id="YP_004650804.1"
                     /db_xref="GI:338204623"
                     /db_xref="GeneID:10865959"
                     /translation="MLGTIIAGVVTYWSTAIDLLIILMLFFAKVKDKKGVRDIYIGQF
                     LGSGLLILVSLFFAVILHYVPDKRLLGFLGIIPVFLGIKALILGDSDGEKMANEKLKD
                     TNQNNLIKTLIFITIVSCGADNVGLFVPYFISLALPKLLITLIVFLIMIFLLVFIAQK
                     SVSIPTVGTVLEKYSRWFIGIVYIFIGGSVLIENGSIQLFINLIK"
     misc_feature    complement(18409..19020)
                     /gene="cadD"
                     /locus_tag="HMPREF0538_22303"
                     /note="Predicted permease, cadmium resistance protein
                     [Inorganic ion transport and metabolism]; Region: CadD;
                     COG4300"
                     /db_xref="CDD:226750"
     misc_feature    complement(18412..18987)
                     /gene="cadD"
                     /locus_tag="HMPREF0538_22303"
                     /note="Cadmium resistance transporter; Region: Cad;
                     pfam03596"
                     /db_xref="CDD:112414"
ORIGIN      
        1 aatattattt tggagtactc agattgaaac atcaagacac cttgagaatt ttctttaata
       61 aatagtcaaa agccaaattt tatttgtagg tgtccagtaa taccaccaca agctaaaagt
      121 attcactggc cattacctga tccggcacaa gcaaaaggca cacatgaaca aaaaatgttt
      181 gtgtttcgac aaacgcgcga tgaaactaaa aaaacgtatt gtccaattag tttaggggct
      241 atttttaata aataacccct taaaaacact attatatcaa gcccttgtat tctataatta
      301 gaatataggg gctatttttt atattttaac tattattacc cctaaaagga gacgcttata
      361 atgttcgatt acaccaccgc aacccgtgat cagaaagaag aatttttgca agacaaaatc
      421 ctaatatgct tacaagctac taaacaacca atgacgaatg ctcagattcg agaatatctg
      481 cttaagcatg ttgatgagtt gccagcaaac gtaactaagc taaccacttc caaaaaaggc
      541 tctgtatact ctgatttcca gatccgtgta aatatgtcca ttacatcctt gtacaagggc
      601 ggtctggttg atcatccaaa gcgaggagta accgaattga ctcaactcgg aaaaagcatc
      661 aatcttaata ctggtcgtaa acatatgcat aaactaattg ttgaggggtg gcaaaaatga
      721 aacaactcgt cctacccatc aaagacagca acattctcca tgaagttcaa gacacgctac
      781 tcaataattt ccgatacggt cgccgtaact atactatctt ccaagttggc aaggcaacct
      841 tgctccgagt gagcgatgtg ttagctctca gacgaaatga aatctttaat gatgatggaa
      901 ctataaagaa gaatgcttat attcgcgata aaaagactga taaacccaac acactgtact
      961 taaagccagt aaatcaggac ttaattgatt accttcagtg gttaaatgaa aataagattc
     1021 aatctgattg gcttttccct tccattaagc accctgaccg acacattacc gagaagcaat
     1081 tttacaagat catggccaaa acaggtgacc tacttggcat caattatcta ggtactcaca
     1141 ccatgagaaa aactggcgcc taccgtgtct acacacagac caattacaat attggcttag
     1201 tgatgagttt gctgaatcat tccagcgaag caatgacact gaaatatttg gggcttgatc
     1261 aagttagtcg agaacaaatg ctagataaag tgagtttcga ctagtgatat ccttaaattc
     1321 tcacaatagc aaaaaaggca acattatcta gcaattagag ataatgttgc ctttttaaca
     1381 caaacaattc taaaaaagag aaaggagtaa tgaccaacct gattagtttc taaggaaaaa
     1441 attattctta gaaaaatttt ttccttagaa actaaatagg caatactgcc aaaaatacta
     1501 atatagaaag gagtccaacc aatggacttt aatgacaaca attttttaaa cgagattaac
     1561 ccccttgatc ttaactcatc aattcctgca acaagagacc ttaaggactc aattcatgcc
     1621 ttggcaatgt taaatggatg cacgatgcaa gaatatttag aacaactcac ctcaacagaa
     1681 attcatcact atgatatcca gaaattgtcc gattaccgta aactcaagtt ttatttcgat
     1741 gcgcgctatc ttaaaaagta taatctaaaa tcgagtagga gataattgat tagttcaatt
     1801 atcgacctct cacaccaccg tacgtacggt tccgtatacg gcggttcgac aacttaatca
     1861 cattgaattg actggagcgt cttggacata ttcataagtc cgagttgttc cagttttcta
     1921 ttagttagag aatagctcaa ggtcttactg tgtgcagttc gccagtagcc cttgcgggta
     1981 ctagcgaaga catatgcatc acgctgggac agccccagct tctgtaagtt agttacctta
     2041 gttttaagct tcttccattg cttccagata tactgtctta ttcgggccct caaccacttg
     2101 tcaaggcgtt gaataaagtc agttagtttc ccaattgagt agtactgaag ccatccacgc
     2161 atttttcgat gaatttcttc aaacattctt gtcagggata ttccacgatt acgtttagtt
     2221 aataacctca atgctttctt tactcgttgt tgcgattgtt ttgctggacg ggcgtaggct
     2281 ccattgtggt ctacacccaa cgaaaagcca agaaacttta accgtagcgg gctaccgact
     2341 ttggttttat ctgggttcac tttaactttc aatcgctttt caagaaactg ggtaatgctt
     2401 cgcattactc gttctccggc tcgttgactt ttaacataaa tgttacaatc atccgcatag
     2461 cgcacaaagt ggtgaccacg tctagtcaac tctttatcca actcatttag atagatattc
     2521 gccagtattg gtgacaatgg ccctccttgt ggggttcctt tttcactctt agcgaaaagc
     2581 ccatggtcta agactccgct agttagaaac ttacgaatga gccttagtgt ccatgggtca
     2641 tcaatatatt gttgaagata cttaatcatc aagtcatgat taacattatc aaaataggct
     2701 tttaggtcta agtcgacaac tcttcgataa ccttgattat aaagatctac tacttttgca
     2761 atagcgtcgt gagccccacg gtgagggcgg aagccaaaac tattatcaga gaaaacacgc
     2821 tcaaagatag gtgtaagaat ttgggccaca gcttgttgaa ccattcggtc caccactgtt
     2881 ggtattccga gttttcttac tccaccatta ggcttcggaa tttctacccg tttgactggt
     2941 gctggtttat acttgccctc acgcaaacta gcgatcaatt ccgtcttatt ttctctgaga
     3001 tatggcagaa ggtcattgac tgtcatatcg tcaatgcctg ctgccccttt atttctctta
     3061 actcgcaaat aagcctgatt aaggttattg cggtccaaga ctaagtcttg gatagtgaca
     3121 ctcatacctt taccttcacc ataatcggta ctacgcgccc ttgtgtactt tcggttttcc
     3181 aaacctatcc tcgacaagcg gtcagcttgt tgttctgttt tctgcgattg tcgcacctga
     3241 ttacacctcc gatataagtt acaagttatt gtcgttcagt ccttcatctg attactcaga
     3301 ctactatgac ctcggctgac ttctggctta ctcaacgcta catcactgca ccgcttgttt
     3361 ctgtggaaat taaacttatt cctcttgtcg gaaacgtgta ggccagatct ccccgggtaa
     3421 ggatattaac tttcgtacca tgtcaccggt agctttactg aaagtaactt cgagtagtgt
     3481 tggactttaa cttgtcatgc agtcttatcc agttagttcc agccttatag ctacttcttg
     3541 ttcatcggtg cagtactttg ccttagactt ccttcagatt ccacctcgca gtggacaccc
     3601 ttgtcctcag ctcatggttc cgactactac ggcccatagc ggactctcac cgcctagcta
     3661 atacccatgc cgggcgcaca taaaaagaaa aaggttagct attattgcta acccttttct
     3721 tttaccccgg ttttaagagt tattagaata atatatcctt taattttttc tttgcatatt
     3781 atttccagtt gcgtttaatc atttttatgt tcagaatcgt atttttcccc cgaaactttc
     3841 atcctttgaa tgatccattg gatggattga gcatataatt ctttttcttt agtattttca
     3901 aataaacaag aatctatatt acttagtgca tcattcaaat catctatcaa caagccaaac
     3961 gatgcagatg aatagttacc aaaatctgta ctatcttcga tattaattgg catttttttt
     4021 agcgcatagt gtctagattg ggcaccattt aaaagaaagg cagaaacatc ttctccagcg
     4081 cctttagccc acttttgaat ttctgttttt tcagctttag tcacgcgagc acgaatagcg
     4141 tcttttttta ctttatcccg attttcatat tttttggctg gcaaaatcat tcctccaatt
     4201 agcgtagcta cgctttaaac taagttatgt ttttttacgc agctacataa ttcatagtta
     4261 aaagcgtaac tacctacatc ttcaaactaa attacttttt tcatcatgta gctacactat
     4321 caatgattaa taatgtagct acgccttaat gtcacttcaa ctaaaaaaca caactacatt
     4381 attattttat gatgtcgtag ctacactttc aacttctaaa agtgtagcta catcttcaaa
     4441 ctaaactact ttttttcatc atgtaaccac actattaatg atagcgtagc tacattatca
     4501 ttttttgatt ccgtaactac gttttcaatg ctgcaaaaaa agtaaaatta gttaatttgc
     4561 tttaattcag actattgttt gctactttaa tatttagatg tatacattat gccgtttaaa
     4621 gactaaaata aaaataagaa agctacaata gaggagttta aaattaaaag taaccaaaat
     4681 agtaaccaat cgcaccacaa caacctttat cttgtaacta gatttaaaca atatgcctta
     4741 caacaagggt taaaaaaaca ctattaaagg aaatggtatt aatgacagta aacaaagtag
     4801 ttataaaaaa taaagctgat atccatcctg aagatactgt taaatacatg gttacaaata
     4861 actatgtaca tgaaagaaaa agcctataca ctaatcacaa agcaaatatt ataaaaaaag
     4921 ggaaaggaaa ttacttcaac aaaaatacag gtgaaaaaat aacaaaagtt aaaaactcaa
     4981 atttaaaaat tcaaaatcgt caatcactaa ttagatccta cgtcaactta cgatacacaa
     5041 tagagaaata tgttacaggt tctatctatg acgaaatgta cactcttact tatgaaaaag
     5101 ctcaaacatc atttaaagac ctgagccacg attttgttac cttcatgaaa cgtttcaaac
     5161 gctatgttaa aaagaactat cctaaagtta acttatcatg gatacgaata aacgaacctc
     5221 ataaagacac aataaacggc aagccaaaat ggcatattca tctaatcgtc ataggacttc
     5281 cttttatgaa gcatcacatt cttgaaaaat tatgggggca tggaatagtc acaatcactt
     5341 catactacaa atgcaatatt cacaaagtag ctaattattt tactggcttc atcaacaaaa
     5401 acgattctga tccagaaagc aaaaaaggac gactaaaata ctatacatct ggcactgacc
     5461 tatttagctt gtctcgagga ttacacgtcc caaaatggat acaaggtaca gaccaagaaa
     5521 ttagaaaaaa acatcctggc aaaattataa atgaaactac tattgaaatt agagatacaa
     5581 acgataacag tctatttaat cgatttgctt accgcgacat cgaatcaaac aaaacaaaat
     5641 aacaaaacaa tttaaaattg tatattatta ccagcaaccc aaaagtgagt attaagtctc
     5701 ttagatgtac ttaatactca cttttgctat acccatcaac tgcgctaacc acttataaaa
     5761 agcctactct accttaactc cccataaagt aactgcgtag catcatcatt acacttcgcc
     5821 ttaatgtggc aaaaatgtaa tgacacaaca tcgtaacact agtcgcttat catcaatcaa
     5881 tctactaata atcattacta gactcattga taatagcaac tcagacagat taagcgcatc
     5941 cagcccttgc ccctaccatt attagagttt gatttgttca actgttttac ttaatttcaa
     6001 acagagcatc gcgaaaactc gagaaaatcg cttaatagta gggttgtccg tcgcattttc
     6061 tggacttcca gccacttctt taaggattgt aagtcctagg gtttagcata ccatttgttt
     6121 accacaggat tgtacgtctc agtcccacgt gtgtttcgag gtgctaccaa cacagtacag
     6181 ctgttttcga gtcaaacggg tgcggcccaa aaagaaaagc acacagcctt ttagccatgt
     6241 gcctagtttt ttggtttatg ttaaattcaa tcacttgaaa ttagctacat ttctcctata
     6301 attaattcat agatagaaat gacaaaccac tagctacgcc cattagctaa ttggttgcct
     6361 gttgtgtact tccaatacat ggcaggcttt ttctttttgc tctaaaatat tcaattttga
     6421 aataaatatt ttgtttcgac tcttaaatta cactatttat tgcacaaagt aaatacttta
     6481 aaataagctg tagtacggta tttataaacc acaattattt attgtagtaa aatatttatt
     6541 gtagtttata aataatagta gtaagcaaat aacttactac tatttcaaag gtgattatat
     6601 caacgtttaa aaaaataagc ttgtaatttg tttactacag taaataattg tagtagataa
     6661 atattttact ataattattt atctagtttt cccattattg tatttattta ctacacttaa
     6721 tcgatatcta taattaactg ttatagttcc tttaccaatt aagattaatc cgagttgtag
     6781 taaagtaatt atagtaacta gaattttttt gttgtaaact tagtttaaag taactaaacc
     6841 tattattatg ggaggtgact accaatgcca actgtactat acggaaacat gaagggtggc
     6901 gtaggcaaaa ctactaatag tgttatgacc gcataccaat tagcaagaaa gggctataaa
     6961 acattagttt gcgatttaga tccacaagca aatgctaccc agttactacg aagaacttat
     7021 ggattgcagc atggcactga tttaaaaatt gaaaaaacaa tgatggtagc tttaaccgaa
     7081 gaaaatattg aacctgctat tgttaatatt atggataatc tgtatcttct tccttcgtca
     7141 gaagacttta aaaattatcc tgatttctta gaaatgaaat ttatgcctga taaagaaaaa
     7201 attctagccg gtaatagcac aaccttgcaa agcgaaatgg ctaaagtaaa agaaaaacga
     7261 attgcttatt tttcgaaaca actggctaaa gtacatgacc aatatgattt catcattatc
     7321 gatgtaccac caacgctttc aatttttaca gattcagcaa tatatgctac taattttgtg
     7381 atcattgttt tacaaaccca acagcgttct ctagatggag ctgaaacatt ttttgaatac
     7441 ctgcaggaaa tgtacaataa ttatgccaat attgactttg atattattgg agttttagca
     7501 gtcctactta aaaataatgc tggtttagat agtcaaattt taaaagatgc tcgcgttgat
     7561 tttggcgacg atatgctatt taatcaaatt attagacaca tggaaagatt gaaacgatac
     7621 gatagaacag ggattgctga aaaaggatta accaagtatg acatgcatga cacacgtcta
     7681 cactatattt acacaaagtt aacagatgaa attattgctc gattaaagga taaaggagca
     7741 cttaactgat ggctaaatat caatttgata agggcacgaa aagaaggtca aaaccaaggc
     7801 ccaagccaat agacaagacc gatatttcaa agccaaaaat aacttataat cctcttactg
     7861 taaccgacag agttgaaaat gatctgcagc ataaaaaaag atcagtagga aggccaaaaa
     7921 caggtcgaaa atcatacaaa acagttcgtt tattaacaag tactgtgttg aagattaatg
     7981 cgttggaaaa tgctcttgga attaagacac aagatgctac tgtagatcaa gccgttgacc
     8041 gagtaattaa ttcattaact aatgatgaaa tgcgagctta taagctgtgg cttgaaatgt
     8101 ttgaaaaaaa agaaaaagaa taggtaagat cataaaattt tgaaaaaata ggtactacta
     8161 aatttaaaat ttagtagtac ctattttttg attaccgttt ctgaattcgt tttttcaatc
     8221 gataaagcgt tgacctagat aggcctgttg cctgttgagt agttctatag tcgctcttca
     8281 taagcagatt gtaaatctgg taatcttgtt gtgtaatctc tcgtttattg cttttatccc
     8341 tatgcaaatc aatctgatgt gtcatttgac acatcttttt tctattagag gaacgttgca
     8401 tcatagtaac catatctgct cgacagagca tcttagctac ataatacggt tcacgactgt
     8461 tactcatacc catttctagc tcgtcgctaa aaattgttat ctgaaggtct tcaatctcgt
     8521 cgagtaagca acataattca cgcacgttag acgtcatatt tgatacgtcc attacatcta
     8581 tcatatcgcc aggtttcaca accataagta atttttgcag ttgaaatcgt gcctgacaca
     8641 ccccagtgaa tgtgtcaata aagtaagcat cataatccac attggtttgt ttaagaaaat
     8701 caatttgaca cgcgattgaa cctttatcat taatgtcatt attagtggtt ccagccacat
     8761 aagcatacat tgacatatgt ttcatatcct ttctatttta ttttttgtat taacagtcta
     8821 aataaaaaaa tttgaaacat ggtatgaaac aaaataacta catcagttcg cataacataa
     8881 attggtataa taagaagaaa taataattac tagaaaaggt agatatgatg caaatagata
     8941 ctagattaat ggagcaggtt aaagatgttc ttcagcaatt cggtactaag tatataacca
     9001 aagatggttc tctaaaacgt aatgccgtta ttagcgacct tgataaatat gataaagact
     9061 taatggtagc attgttggcc aacaatctta ttaaagatga atatactgaa caaatagctg
     9121 atacaacagt attcaaatta aatcacttta ttgaaatgtt tgaatatcaa gagttttggg
     9181 gtaatagttt taccaaatac gccaaccgaa ttggccttac cagtgatgat aaattcatta
     9241 gtgactcaga cgatgttgta ttagatttcc cctataaaga tactgttcta aaagcaggta
     9301 tgactaaaga tgatgttgat aaagaagtcg gggctgatga accttttttg aacgaaacat
     9361 tagctcattc tgaaattagt gagttatttg aaccaaaagt attagttaat gcaaaactat
     9421 acgatacaga aggcgaacac aaagctacca attttgatga taatgataat ttagtaatta
     9481 agggcaataa tttaatcgct ctacatagta ttgccaaaaa gtacgccgga aaaattaaac
     9541 tcatttattt ggatccaccc tataacacag gatctgattc ctttaaatat aatgatcgat
     9601 ttagtcatgc tacttggctc acgtttatga agagtcgatt ggaaatagca aaaacgctaa
     9661 tgtctgataa cggggtcatt gctatccaac tggatgattc tgagggacca tatctaaagg
     9721 tactgacaga ctcaatattt ggtcgtgaca atgaattatt cacgcaatat gtgttagtcc
     9781 gatatgctaa taagacattg aaatcagata tggattatca taaacaaata gaacaaatcc
     9841 attactataa aaaaaattct aatgctgagg taaaacccaa caaggacaaa gttccatatg
     9901 attattcaaa attctgttac gaagttaaaa cgactgggaa accttcttca tcaattatgc
     9961 ttggcgataa acaagttgat attttcacta aagaccaggt tgagtttaag aaaacctccg
    10021 gtaatccgga aggtcttaaa gaaatatggg cttctggaac aatcttaaat ggtaattcct
    10081 ctggaagatt ttttagagat tatttaagtg gccgttataa aaaagatggt tatggtgtgg
    10141 tctataaagt ttatgatata ggcgatgatg gtaatgacta tagattcttt acaggtccaa
    10201 agaaagcagg agctactaaa ggaaagtatt atcaaggagt tcccctagat gttaaaaacg
    10261 gtaaaactag tcaaaagtta ttgcctatac caggcttcat tgatatggca ggttcatttg
    10321 gaaacgatcg tcttgaagga ggcgtcgaat taagaaatgg aaaaaagcct gagaaattat
    10381 tgaaaaatat tattaaatat tttagtaata aaaatgatta tgttatggac tttttcgctg
    10441 gtagtggctc aacgttagct acagcaatga aaatgagtcg aaaatttata gcaatcgaac
    10501 aaattaatga acaaatcata aaaatcaata aacgattaaa taatgttatt catggtgatc
    10561 aaactggtat ttccaaggaa gttaattggc aaggtggcgg ttcatttgtc tacaccgaac
    10621 ttatgaaaaa gaaccaggga tttctttatg accttcagaa ggcaactacc attgacgagc
    10681 ttaatgcagt ttatgaccga atgaaacagg gtgctgatct agattttcgt gtcgacttaa
    10741 ataaatttga aaatgattct gaacgtgctt ctctaccatt tgaagatcag aaaaagctgt
    10801 taatcaagct acttgataag aaccaacttt actataacga agccaatatt gatgatgcag
    10861 acgtccgtga cctgatctcg gatagtgatt atcgattcaa taagagcttc tacaacggga
    10921 aggagtcaaa gtaatggctc gtaaaaaaac aatacccgaa gaaaaaattg atctccaatt
    10981 actaaatgct cttaacagca ccagcctttt ttcactcaaa tcatccttag aggataatcc
    11041 cctttacatt actaataatc taaaacacaa actccgtaat taccaaatgg atgctgtcca
    11101 tcacctcgat gcagtactca acatgaagga tgctgaccaa cgtaatcagt tgatgtttta
    11161 catggccaca ggatctggaa agaccgatat tatggccgca attatcctgt atatgtttcg
    11221 tgcctggggt tatcaatgct tcttgtttac cactaataca actgctgttg tcgacaagac
    11281 tattgataac ttagtaaata gtgcttctgc taagtacctt tacaacaatc cattagttat
    11341 tgatggcgat catgttacga ttaaaaaagt cgaccgatat ccagtaaatc ttgaaaagga
    11401 tacaatatat atcaaacttg ctggcattca acaattatca aatgactatt acgcccccag
    11461 agaaaatgga attaccaagg attcactggc aagacataaa ttagtcctgc ttgccgacga
    11521 agcacaccac tttaatgttt ctactcgcag taagaaagct aatcgggagg gacttagttg
    11581 ggagcatttg cttgatgaga tcaggcaatt aaatcatgaa aataaacaac ttgaatttac
    11641 tgcgactatc gatcttcata atcctgacat ttaccacaag tatcaaaata agatcattgc
    11701 acaatatgat cttagccact tcattaatga tgggttttcc aaaaaggtct accggcttca
    11761 agcaaataat agtgatgaaa ataagatgct caatgctgta ctcttatcac aatatcggaa
    11821 gcgtattgct caaaacatga gtattcccga ctttaagcct gtaatcttgt tcaaatcgaa
    11881 tacaatcgct gaatcaaggg ctatcaacga aacctttttg acaatgattg acaacctatc
    11941 agcagaatcg ttgcaacaat ttatacagaa tcaaaaccgt tcaacgcaaa gtgaagcact
    12001 cagtcttgct tacaagtatt ggctaaatca agattttggt tctacagtaa ccgagttaaa
    12061 acgcgatttt agcaagttta caacgattaa cgcgaatgac tctggaagta agaacattct
    12121 tgatgacgaa tcagtttcaa gaaggctcaa ttctttggaa agtcctgaca acccgattcg
    12181 ctctgtcttc gccgttgcta agttgagtga aggttgggac gttttgaacc tctttgacat
    12241 cgtccggatt ggcgaaaaaa atatcaagcc taaagataca aatgctgaag cccagcttat
    12301 tggacgtggt gccagatact atccattcgt ttatcacgga aagaagtcat atacgagaag
    12361 atttgatgac cgtaaaccag aaattcagct tttggagcgt ttgtactacc acactattaa
    12421 cgatccacaa tatctggaaa atcttagaaa atcactagat gcaattgatc tacctgttaa
    12481 tgaagatact caatacaagg tgtacaccgc taaagtaaag aattcgttta agaagaccaa
    12541 agcatataag catgggaata tttactataa taaggtcatt gacgttcctg aatcgcatta
    12601 cgattctatt cagaagtacg gcttcgatcc tgaaacaact ggaccaattg atatggttga
    12661 tgctgtttct gagcgaagat acgatactgg tgcggataag aacgatacca cctctacaac
    12721 acttgaagtt gctgctagat ttagcaatcc tcaagataag gcacttatac gtacagccgt
    12781 gtccttcaat aacttctacc gttttgactc ccttaaaaaa tactgtccta ctttaacaag
    12841 catgcgagaa ttcttaacta gcaatgaatg gttagggaac gccaccataa gagttaaggt
    12901 agcaaccggt tctcctgctc taactaacga acaacgatta acagcagtta aaaagtattt
    12961 agtccgtgtg caaacagcaa tctctaataa cttcaaacgc tctattggta ctaacgagtt
    13021 tatgcctatc gccgttaatg aagttattca agattatcaa aagcgtgttg gtgatcaatt
    13081 cggcaagagt gccttaatag gccctgattc gatgcagggc aaagactggt atgtctatga
    13141 ttatgcgatt gtagataccc ttgaaaagca ctttattgac catatcaata gtattatgcc
    13201 tgaactaaca catcagtacg ggcaagctta tctactacgt attgatgaac gtacaactga
    13261 tttcaagtta catgattttg gtgagaatat tttccattac gaaggatata tgcctgactt
    13321 tattctttac cttgagaatg agaactttat ctatcagata ttccttgaac ctaaagggac
    13381 accttatata gaaagggata aatggaagga aaaacttctg gaacgaatta atcctgacaa
    13441 tattaaagtc ctaggtgaag acgaaaaagt taagatctat ggcctgaaat tctatgttga
    13501 agatgatggc aaagaagata cccacggttt attccaagag atgcgcgaca agaatatctt
    13561 gcagtaacct catgagtggt aaactattcg attcatgata taatgtttat agagattaag
    13621 tcgttatgag gttcatagcg caacacaaaa gcccccagca aggtccgaag atgctgaggg
    13681 cttttattgt gggcttgtgc cgttcgatta ctcgttaatg gtgtcggttg ttaagccacc
    13741 agctgaacca tactacgatg agcgaactaa cgagcgagat taagtcgttt aaaaggtcca
    13801 tagccaccac cccctctcta tcacgacaag gggacgaacg acaatattaa gtatagcaac
    13861 ttctaagcga tctgaaagta ttaagattct gacctgaaaa cgtggagagt gtaacatctg
    13921 ttaatgttag tgcggtaact aaagtaggca tatttctctg cgttaatttc aactttgtct
    13981 cctccatttt tttgaaatac actttattaa aatagtcata tgtgtcgtaa atatggagaa
    14041 gccagcatat ataaaaaaga gtgccatgtg acactctttt tgagctattt aatatcaaca
    14101 acaccgacaa attcaacatc atcaattgca gttaagtaaa aactatcagt tggtccaagt
    14161 attgcaagtt gaccattttt gattgtacat tcttgatctg gtgtggtcag tttcaccgtc
    14221 ccttttaagg gaatgagaac tatatttcca ggtacagggt gaaattctcc gttgtttgtc
    14281 actgtatttt tctttagtat acgatgacca acccgtcttt gaccattttc gtaaaggtgt
    14341 tcatggacct catcaccgcg actaccagtt aatattttca tataatatat actcccaagt
    14401 taattgactt ttttacgtgg cttttcagta ttattggaat tttgttgagt gttgtttcca
    14461 cagcagccca tactaccaga gccaccgtgc atacccttgt gcataaatag catcatgagt
    14521 gggtgtgcta gaagaaaaag ggctatcaga atccattgtg acatagtttc acttcctttt
    14581 gctttgtttc tataataagt ttttgtcatc acttgtttgt cactgtattt ttctttagta
    14641 tacgatgacc aacccgtctt tgaccatttt tgtaaaggtg ttcatggacc tcatcaccgc
    14701 gactaccagt taatattttc atataatata tactcccaag ttaattgact tttttacgtg
    14761 gcttttcagt attattggaa ttttgttgag tgttgtttcc agagccaccg tgcataccct
    14821 tgtgcataaa tagcatcatg agtgggtgtg ctagaagaca aagggctacc agaatccatt
    14881 gtgacatagt ttcacctcct tttgctttgt ttctataata agtttttgtc atcacttaat
    14941 tacacgtttt taatcttttc accagtcaat cccatcgcat taattgccac gataattgtc
    15001 gacatcgcca tgaccgcagc accaacggct gggtctagaa tgattccaat aaatgacaac
    15061 acaccggcag cgagtggaat tgcgacaaca ttgtagcctg ctccccacca gagattttga
    15121 accattttcc gatttgtgat tttagccaaa tcaagaaaat gtaaaatatc gctgggttct
    15181 gatttaacca acacaacatc agcggaatca atggcaacat cggttccggc gccaattgca
    15241 attccaatat cggccgcggc aagacttggt gcgtcattta cgccgtcacc aaccatgatg
    15301 acgtgattgc cctttgcttg ataatcagca ataatctttt gcttatcatc tggtaatagg
    15361 cctgcatgga attcagtcaa tcctagtaag ttagcaacgt gttccgcggc ttttggatta
    15421 tcgccagtga gcattacggg ggtaattcct cgcctctgaa gaccactaat taattcctta
    15481 gctcccgctt tgatggtgtc gccttcggca accattcctt gaacttgggt gccctgcaat
    15541 aggaagctaa cggaattacc cttagcagcc catttatcag cagcggcctc gtcaaacctg
    15601 atcccttgct tcgttaaata gttaccatta acaatcatat agtcagtgcc atcaacatta
    15661 ccggaaatac caacgcccgg aatattttga gacttttcag ccgcaacgac ctcaatgttc
    15721 ttcgcttggg cttcagtaat gattgcttgg gccagcggat gagtcgaatt aatttcaagg
    15781 gcggccagtc ggcttaataa cgttgtttcg tcaatcccat catttggaat caatgcattc
    15841 actgtaaatt taccttctgt taacgtgcca gttttatcca agagaacgtg gctaacatgt
    15901 tgacttgctt caatggcttg gcgatttcga actaatagcc cattttgagc gccgatagta
    15961 gtagaacgag aaaccactaa tggaatcgct aatcctaatg catgcgggca agcaatcacg
    16021 aagacggtca ccatgatcgt cattgcagtc gccaatccct ggggtaacca ggcaaagaaa
    16081 gcaataatcc caacaccaag tgccgcgtaa aatagatact ttgcaactaa atcagcttta
    16141 tcttctgctt tagatttagc ttgctgggca ttttgaacca ttttcattac ttgagaaaga
    16201 tagctggagt caccagtacc actaatttta accgttagcg tcccgttatt gttggttgta
    16261 ccaccaatga ccttatcgcc aacgttcttg gtaacggcag cagattcacc ggttaccagt
    16321 gcttcattca cggtcgactc cccagccgta ataacaccat cggctggaat actctcacct
    16381 gaacgcactt ggaaagcttg accaactttt aaatcagata ctggcacttc ttttgtttca
    16441 ccattatctg taactagatg ggccgtctta ggcaacaggg ccgccatctt ttgtaaggca
    16501 ttcccagccc ccatcaatgc attcatttca atccagtgtc ctagaagcat aattaaaatc
    16561 agggttgcaa gttcgaacga aaaatccatt atatgatttg tcgggttcaa gaagttgttg
    16621 gcaataaatg cgtacaaact gtagaaatac gaaacggaaa ttccaagggt tactagcgtc
    16681 atcatttcag gagatttatt ctgaatttcc gctttagccc cctttaaaaa tggcattccg
    16741 ccataaaagt aaagtgctgt atcaaacaaa acgatgataa tgccaacaat tagcggtgaa
    16801 ctgaaactaa ggatggaaac gtttaaaccc atgattggtg ctaacagtaa aactggaatc
    16861 gctaagacaa cggagaccca aaatttaact ttcaaattcc ccatatgcat cattgagcca
    16921 ccgtgcatca tcatgtcggc cccagccata tccatatcac cgtgattcat gttcatttgg
    16981 ctgtgatccg tttcggtcat atcgtgatcc atatgactca tatttgattc attattttcc
    17041 atattcttag cactcatgtt tttcatgttc atatggccct ctttatttgc catgattatc
    17101 gaccccctaa aaataagtgt gcgtagcaaa gcggttagaa gccggaatat aagttccttg
    17161 tgtggaaatt cccgggctcg ggattttccc accagattct tatatttagg cttctgcttt
    17221 gcggagcacc atgccactat atgaatgaga attacgacaa aagttcataa gtttccgcca
    17281 tcaggaatcc cagattctgg atttttgtgc agcaatccta aaagtaaaca gaacaccaca
    17341 gtcttaacac gtttgatcac ctggcaagca gttacactga acttcttcgg gcgctgtttt
    17401 ggccttttca gctagaatcg cctgtaagtt cgcaatatcc gcccgtgaga gttcccttga
    17461 ctgaataacg ccggcaattg ttgaaccagc ccgcatcgca cacatatggt caaacaaatc
    17521 atctgccgct gccgccattg attccttctc gccaacaacc ggcttatacg tgaatggtcg
    17581 actgccgcca tgctgcgcaa ccgcctgttt ttgaatcaac ctgtgaagta gcgttttggt
    17641 tgttgaagct gaccagcctt ctaattcgtt catagcatcg attagttcac gactagtcgc
    17701 atgtcccatt gtccaaattg ctctcataac catccattca gaatcggtga tggttacatt
    17761 ctttggatcc ttcaattggc ttcctccatt aattgaatta taagtttaca tttgtagtct
    17821 cttaatgctt attagtttac aactgtagtc acaataatgc aacctttctg ccagaaaata
    17881 ccatgacact aaaaaaacgc ctagataata ttccagacgt ggtttgatac gatatattaa
    17941 attacgttag ttgctagttt gtaacattcc catgacttct aaattatggg tcagcataat
    18001 tactttctct tcttaaggga agcacttaag tcaattcacc tgtcaagttg agcaagtatt
    18061 tttttcagat catcatcttt tataaagtag tacaccattt tccccttttt ttgacggtct
    18121 aaaatgtcag catcatacag cattcttaag tgatgagaag cggttgcaat actacagcct
    18181 aaaatatatg caatatcaca aacacataac gattcctgag cgattaaaga gaaaatgatt
    18241 tttaactttt tctcatctga gattttagac aatacataaa agtatttctt aatacgtgat
    18301 ttacccaaga attccgagac cttcattact ttatctgtct caaccaatgt ctgatcacaa
    18361 gtaatgtcag cacttttgct tttcatagaa tcactctgcc tattatttaa ttaaattaat
    18421 gaaaagttga attgatccat tttcgatcaa aacggaacca ccaataaaga tataaacgat
    18481 tcctataaac caacgactat atttttcaag aactgtacct acagttggaa tactaaccga
    18541 cttctgggca ataaaaacta ataagaaaat cattatcaaa aacacgatta aagttattaa
    18601 taactttggt agtgccaaac taataaagta aggtacaaat aatccaacat tatcagcacc
    18661 acagctcaca atagtaatga aaatcaaggt tttaatcaaa ttattttgat ttgtatcttt
    18721 caatttttca ttagccattt tttcaccgtc tgaatctccc aaaattaaag cctttattcc
    18781 caaaaagaca ggaattattc ctagaaaacc taataatcgt ttatcaggaa cgtaatgtaa
    18841 aatgacagca aagaacaaac taactaatat caaaagccca gacccaagaa attggcctat
    18901 ataaatatct ctaacaccct ttttatcttt aactttcgca aaaaaaagca tcagaattat
    18961 taataagtca atagcagtac tccagtaagt caccacacca gcaataattg ttcctaacat
    19021 ttcttatttc ctccaaaata atattcaaat atatatttg
//
