LBL_4000	nucleoside	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4000	triphosphate	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4000	containing	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4000	hydrolase	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4003	domain-like	IPR008979 - Galactose-binding domain-like
LBL_4004	reductase	IPR003171 - Methylenetetrahydrofolate reductase
LBL_4005	enzyme	IPR003773 - Menaquinone biosynthesis enzyme
LBL_4005	biosynthesis	IPR003773 - Menaquinone biosynthesis enzyme
LBL_4006	had-superfamily	IPR006379 - HAD-superfamily hydrolase, subfamily IIB
LBL_4006	subfamily	IPR006379 - HAD-superfamily hydrolase, subfamily IIB
LBL_4006	hydrolase	IPR006379 - HAD-superfamily hydrolase, subfamily IIB
LBL_4010	barrel	IPR013785 - Aldolase-type TIM barrel
LBL_4011	aminotransferase	IPR005814 - Aminotransferase class-III
LBL_4011	transferase	IPR015424 - Pyridoxal phosphate-dependent transferase
LBL_4012	histidine	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4012	kinase-like	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4012	atpase	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4012	c-terminal	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4012	c-terminal	IPR004358 - Signal transduction histidine kinase-related protein, C-terminal
LBL_4012	signal	IPR004358 - Signal transduction histidine kinase-related protein, C-terminal
LBL_4012	histidine	IPR004358 - Signal transduction histidine kinase-related protein, C-terminal
LBL_4013	dna-binding	IPR011991 - Winged helix-turn-helix DNA-binding domain
LBL_4014	decarboxylase	IPR000257 - Uroporphyrinogen decarboxylase (URO-D)
LBL_4015	radical	IPR007197 - Radical SAM
LBL_4020	nucleoside	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4020	triphosphate	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4020	containing	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4020	hydrolase	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4028	fold	IPR014710 - RmlC-like jelly roll fold
LBL_4029	reductase	IPR002347 - Glucose/ribitol dehydrogenase
LBL_4029	dehydrogenase	IPR002347 - Glucose/ribitol dehydrogenase
LBL_4032	domain-like	IPR029060 - PIN domain-like
LBL_4033	reductase	IPR002347 - Glucose/ribitol dehydrogenase
LBL_4033	dehydrogenase	IPR002347 - Glucose/ribitol dehydrogenase
LBL_4036	ribonuclease	IPR012337 - Ribonuclease H-like domain
LBL_4042	nucleoside	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4042	triphosphate	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4042	containing	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4042	hydrolase	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4043	factor	IPR002035 - von Willebrand factor, type A
LBL_4045	factor	IPR002035 - von Willebrand factor, type A
LBL_4046	factor	IPR002035 - von Willebrand factor, type A
LBL_4047	helical	IPR011990 - Tetratricopeptide-like helical domain
LBL_4049	histidine	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4049	kinase-like	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4049	atpase	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4049	c-terminal	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4049	ribosomal	IPR020568 - Ribosomal protein S5 domain 2-type fold
LBL_4049	fold	IPR020568 - Ribosomal protein S5 domain 2-type fold
LBL_4061	nucleoside	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4061	triphosphate	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4061	containing	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4061	hydrolase	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4062	(vitamin	IPR006158 - Cobalamin (vitamin B12)-binding domain
LBL_4062	cobalamin	IPR006158 - Cobalamin (vitamin B12)-binding domain
LBL_4062	catalytic	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4062	enzyme	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4062	(vitamin	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4062	cobalamin	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4064	methyltransferase	IPR029063 - S-adenosyl-L-methionine-dependent methyltransferase-like
LBL_4065	histidine	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4065	kinase-like	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4065	atpase	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4065	c-terminal	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4068	periplasmic	IPR029151 - Periplasmic sensor domain-like
LBL_4068	domain-like	IPR029151 - Periplasmic sensor domain-like
LBL_4068	cyclase	IPR029787 - Nucleotide cyclase
LBL_4068	nucleotide	IPR029787 - Nucleotide cyclase
LBL_4072	c-terminal	IPR015893 - Tetracycline transcriptional regulator, TetR-like, C-terminal
LBL_4072	transcriptional	IPR015893 - Tetracycline transcriptional regulator, TetR-like, C-terminal
LBL_4072	regulator	IPR015893 - Tetracycline transcriptional regulator, TetR-like, C-terminal
LBL_4084	helical	IPR011990 - Tetratricopeptide-like helical domain
LBL_4092	transferase	IPR016035 - Acyl transferase/acyl hydrolase/lysophospholipase
LBL_4092	acyl	IPR016035 - Acyl transferase/acyl hydrolase/lysophospholipase
LBL_4092	hydrolase	IPR016035 - Acyl transferase/acyl hydrolase/lysophospholipase
LBL_4092	acyl	IPR016035 - Acyl transferase/acyl hydrolase/lysophospholipase
LBL_4098	methyltransferase	IPR029063 - S-adenosyl-L-methionine-dependent methyltransferase-like
LBL_4099	glycoside	IPR011330 - Glycoside hydrolase/deacetylase, beta/alpha-barrel
LBL_4099	hydrolase	IPR011330 - Glycoside hydrolase/deacetylase, beta/alpha-barrel
LBL_4099	beta	IPR011330 - Glycoside hydrolase/deacetylase, beta/alpha-barrel
LBL_4100	helical	IPR011990 - Tetratricopeptide-like helical domain
LBL_4102	iia	IPR006357 - HAD-superfamily hydrolase, subfamily IIA
LBL_4102	subfamily	IPR006357 - HAD-superfamily hydrolase, subfamily IIA
LBL_4102	had-superfamily	IPR006357 - HAD-superfamily hydrolase, subfamily IIA
LBL_4102	hydrolase	IPR006357 - HAD-superfamily hydrolase, subfamily IIA
LBL_4104	dna-binding	IPR011991 - Winged helix-turn-helix DNA-binding domain
LBL_4104	methyltransferase	IPR029063 - S-adenosyl-L-methionine-dependent methyltransferase-like
LBL_4107	(vitamin	IPR006158 - Cobalamin (vitamin B12)-binding domain
LBL_4107	cobalamin	IPR006158 - Cobalamin (vitamin B12)-binding domain
LBL_4107	synthase-like	IPR011005 - Dihydropteroate synthase-like
LBL_4110	atp-dependent	IPR022953 - Phosphofructokinase
LBL_4111	domain-like	IPR029016 - GAF domain-like
LBL_4112	glutamate	IPR001048 - Aspartate/glutamate/uridylate kinase
LBL_4112	kinase	IPR001048 - Aspartate/glutamate/uridylate kinase
LBL_4113	reductase	IPR002347 - Glucose/ribitol dehydrogenase
LBL_4113	dehydrogenase	IPR002347 - Glucose/ribitol dehydrogenase
LBL_4115	fold	IPR012336 - Thioredoxin-like fold
LBL_4120	core	IPR011010 - DNA breaking-rejoining enzyme, catalytic core
LBL_4120	catalytic	IPR011010 - DNA breaking-rejoining enzyme, catalytic core
LBL_4120	enzyme	IPR011010 - DNA breaking-rejoining enzyme, catalytic core
LBL_4120	dna	IPR011010 - DNA breaking-rejoining enzyme, catalytic core
LBL_4120	catalytic	IPR013762 - Integrase-like, catalytic core
LBL_4121	nucleoside	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4121	triphosphate	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4121	containing	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4121	hydrolase	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4124	pheromone	IPR002816 - Pheromone shutdown, TraB
LBL_4125	histidine	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4125	kinase-like	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4125	atpase	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4125	c-terminal	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4127	fold	IPR029058 - Alpha/Beta hydrolase fold
LBL_4127	beta	IPR029058 - Alpha/Beta hydrolase fold
LBL_4127	alpha	IPR029058 - Alpha/Beta hydrolase fold
LBL_4127	hydrolase	IPR029058 - Alpha/Beta hydrolase fold
LBL_4131	fold	IPR013783 - Immunoglobulin-like fold
LBL_4134	transport	IPR003400 - Biopolymer transport protein ExbD/TolR
LBL_4141	nucleoside	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4141	triphosphate	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4141	containing	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4141	hydrolase	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4142	(vitamin	IPR006158 - Cobalamin (vitamin B12)-binding domain
LBL_4142	cobalamin	IPR006158 - Cobalamin (vitamin B12)-binding domain
LBL_4142	catalytic	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4142	enzyme	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4142	(vitamin	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4142	cobalamin	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4143	(vitamin	IPR006158 - Cobalamin (vitamin B12)-binding domain
LBL_4143	cobalamin	IPR006158 - Cobalamin (vitamin B12)-binding domain
LBL_4143	catalytic	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4143	enzyme	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4143	(vitamin	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4143	cobalamin	IPR016176 - Cobalamin (vitamin B12)-dependent enzyme, catalytic
LBL_4144	integral	IPR005496 - Integral membrane protein TerC
LBL_4144	membrane	IPR005496 - Integral membrane protein TerC
LBL_4147	transferase	IPR015424 - Pyridoxal phosphate-dependent transferase
LBL_4152	protease	IPR026898 - Protease PrsW
LBL_4154	finger	IPR000962 - Zinc finger, DksA/TraR C4-type
LBL_4154	zinc	IPR000962 - Zinc finger, DksA/TraR C4-type
LBL_4155	ribosomal	IPR011332 - Zinc-binding ribosomal protein
LBL_4158	methyltransferase	IPR004033 - UbiE/COQ5 methyltransferase
LBL_4158	methyltransferase	IPR029063 - S-adenosyl-L-methionine-dependent methyltransferase-like
LBL_4160	transport	IPR003400 - Biopolymer transport protein ExbD/TolR
LBL_4163	transferase	IPR004299 - Membrane bound O-acyl transferase, MBOAT
LBL_4163	membrane	IPR004299 - Membrane bound O-acyl transferase, MBOAT
LBL_4164	esterase	IPR013830 - LBL_4164|LBL_4164|YP_799412.1|GeneID:4409044
LBL_4165	transferase	IPR004299 - Membrane bound O-acyl transferase, MBOAT
LBL_4165	membrane	IPR004299 - Membrane bound O-acyl transferase, MBOAT
LBL_4171	ribosomal	IPR020568 - Ribosomal protein S5 domain 2-type fold
LBL_4171	fold	IPR020568 - Ribosomal protein S5 domain 2-type fold
LBL_4179	major	IPR011701 - Major facilitator superfamily
LBL_4179	major	IPR020846 - Major facilitator superfamily domain
LBL_4180	haem	IPR016053 - Haem oxygenase-like
LBL_4180	haem	IPR016084 - Haem oxygenase-like, multi-helical
LBL_4183	peptidase	IPR009003 - Trypsin-like cysteine/serine peptidase domain
LBL_4184	peptidase	IPR001940 - Peptidase S1C
LBL_4184	peptidase	IPR009003 - Trypsin-like cysteine/serine peptidase domain
LBL_4192	fold	IPR012336 - Thioredoxin-like fold
LBL_4194	synthase-like	IPR017938 - Riboflavin synthase-like beta-barrel
LBL_4194	beta-barrel	IPR017938 - Riboflavin synthase-like beta-barrel
LBL_4197	biosynthesis	IPR006365 - Cobalamin (vitamin B12) biosynthesis CobL/Precorrin-6Y C(5,15)-methyltransferase
LBL_4197	(vitamin	IPR006365 - Cobalamin (vitamin B12) biosynthesis CobL/Precorrin-6Y C(5,15)-methyltransferase
LBL_4197	cobalamin	IPR006365 - Cobalamin (vitamin B12) biosynthesis CobL/Precorrin-6Y C(5,15)-methyltransferase
LBL_4197	methyltransferase	IPR029063 - S-adenosyl-L-methionine-dependent methyltransferase-like
LBL_4202	nucleoside	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4202	triphosphate	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4202	containing	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4202	hydrolase	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4203	nucleoside	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4203	triphosphate	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4203	containing	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4203	hydrolase	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4205	nucleoside	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4205	triphosphate	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4205	containing	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4205	hydrolase	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4206	transferase	IPR015424 - Pyridoxal phosphate-dependent transferase
LBL_4206	nucleoside	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4206	triphosphate	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4206	containing	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4206	hydrolase	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4208	histidine	IPR029033 - Histidine phosphatase superfamily
LBL_4208	phosphatase	IPR029033 - Histidine phosphatase superfamily
LBL_4213	ribonuclease	IPR012337 - Ribonuclease H-like domain
LBL_4214	ribonuclease	IPR012337 - Ribonuclease H-like domain
LBL_4219	dna-binding	IPR011991 - Winged helix-turn-helix DNA-binding domain
LBL_4219	polymerase	IPR013324 - RNA polymerase sigma factor, region 3/4
LBL_4219	factor	IPR013324 - RNA polymerase sigma factor, region 3/4
LBL_4219	sigma	IPR013324 - RNA polymerase sigma factor, region 3/4
LBL_4219	rna	IPR013324 - RNA polymerase sigma factor, region 3/4
LBL_4219	rna	IPR014284 - RNA polymerase sigma-70 like domain
LBL_4219	polymerase	IPR014284 - RNA polymerase sigma-70 like domain
LBL_4222	glycoside	IPR017853 - Glycoside hydrolase, superfamily
LBL_4222	hydrolase	IPR017853 - Glycoside hydrolase, superfamily
LBL_4223	transferase	IPR016035 - Acyl transferase/acyl hydrolase/lysophospholipase
LBL_4223	acyl	IPR016035 - Acyl transferase/acyl hydrolase/lysophospholipase
LBL_4223	hydrolase	IPR016035 - Acyl transferase/acyl hydrolase/lysophospholipase
LBL_4223	acyl	IPR016035 - Acyl transferase/acyl hydrolase/lysophospholipase
LBL_4224	major	IPR011701 - Major facilitator superfamily
LBL_4224	major	IPR020846 - Major facilitator superfamily domain
LBL_4226	phosphatase-like	IPR029052 - Metallo-dependent phosphatase-like
LBL_4227	barrel	IPR013785 - Aldolase-type TIM barrel
LBL_4227	glutamate	IPR024188 - Glutamate synthase large subunit-like protein
LBL_4227	large	IPR024188 - Glutamate synthase large subunit-like protein
LBL_4227	synthase	IPR024188 - Glutamate synthase large subunit-like protein
LBL_4231	reductase	IPR002347 - Glucose/ribitol dehydrogenase
LBL_4231	dehydrogenase	IPR002347 - Glucose/ribitol dehydrogenase
LBL_4232	dehydratase	IPR017714 - Methylthioribulose-1-phosphate dehydratase
LBL_4233	dioxygenase	IPR004313 - Acireductone dioxygenase ARD family
LBL_4233	fold	IPR014710 - RmlC-like jelly roll fold
LBL_4234	translation	IPR008991 - Translation protein SH3-like domain
LBL_4234	ribosomal	IPR014722 - Ribosomal protein L2 domain 2
LBL_4234	elongation	IPR020599 - Translation elongation factor P/YeiP
LBL_4234	translation	IPR020599 - Translation elongation factor P/YeiP
LBL_4234	factor	IPR020599 - Translation elongation factor P/YeiP
LBL_4236	glutamate	IPR003739 - Lysine-2,3-aminomutase family
LBL_4236	barrel	IPR013785 - Aldolase-type TIM barrel
LBL_4241	barrel	IPR013785 - Aldolase-type TIM barrel
LBL_4242	methyltransferase	IPR029063 - S-adenosyl-L-methionine-dependent methyltransferase-like
LBL_4243	decarboxylase	IPR003826 - S-adenosylmethionine decarboxylase family, prokaryotic
LBL_4244	decarboxylase	IPR003826 - S-adenosylmethionine decarboxylase family, prokaryotic
LBL_4246	decarboxylase	IPR009006 - Alanine racemase/group IV decarboxylase, C-terminal
LBL_4246	c-terminal	IPR009006 - Alanine racemase/group IV decarboxylase, C-terminal
LBL_4246	barrel	IPR029066 - PLP-binding barrel
LBL_4251	histidine	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4251	kinase-like	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4251	atpase	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4251	c-terminal	IPR003594 - Histidine kinase-like ATPase, C-terminal domain
LBL_4251	c-terminal	IPR004358 - Signal transduction histidine kinase-related protein, C-terminal
LBL_4251	signal	IPR004358 - Signal transduction histidine kinase-related protein, C-terminal
LBL_4251	histidine	IPR004358 - Signal transduction histidine kinase-related protein, C-terminal
LBL_4253	c-terminal	IPR015893 - Tetracycline transcriptional regulator, TetR-like, C-terminal
LBL_4253	transcriptional	IPR015893 - Tetracycline transcriptional regulator, TetR-like, C-terminal
LBL_4253	regulator	IPR015893 - Tetracycline transcriptional regulator, TetR-like, C-terminal
LBL_4254	alpha	IPR001030 - Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
LBL_4254	dehydratase	IPR001030 - Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
LBL_4254	aconitase	IPR001030 - Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
LBL_4254	large	IPR001030 - Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
LBL_4254	alpha	IPR001030 - Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
LBL_4254	beta	IPR001030 - Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
LBL_4254	dehydratase	IPR015928 - Aconitase/3-isopropylmalate dehydratase, swivel
LBL_4254	aconitase	IPR015928 - Aconitase/3-isopropylmalate dehydratase, swivel
LBL_4256	synthetase	IPR006195 - Aminoacyl-tRNA synthetase, class II
LBL_4256	aminoacyl-trna	IPR006195 - Aminoacyl-tRNA synthetase, class II
LBL_4259	dna-binding	IPR011991 - Winged helix-turn-helix DNA-binding domain
LBL_4267	kinase-like	IPR011037 - Pyruvate kinase-like, insert domain
LBL_4267	pyruvate	IPR011037 - Pyruvate kinase-like, insert domain
LBL_4267	pyruvate	IPR015795 - Pyruvate kinase, C-terminal
LBL_4267	kinase	IPR015795 - Pyruvate kinase, C-terminal
LBL_4267	c-terminal	IPR015795 - Pyruvate kinase, C-terminal
LBL_4267	pyruvate	IPR015813 - Pyruvate/Phosphoenolpyruvate kinase-like domain
LBL_4267	kinase-like	IPR015813 - Pyruvate/Phosphoenolpyruvate kinase-like domain
LBL_4269	dehydrogenase	IPR012080 - Aspartate-semialdehyde dehydrogenase
LBL_4272	transferase	IPR004299 - Membrane bound O-acyl transferase, MBOAT
LBL_4272	membrane	IPR004299 - Membrane bound O-acyl transferase, MBOAT
LBL_4277	nucleoside	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4277	triphosphate	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4277	containing	IPR027417 - P-loop containing nucleoside triphosphate hydrolase
LBL_4277	hydrolase	IPR027417 - P-loop containing nucleoside triphosphate hydrolase