LOCUS       NC_019145               7609 bp    DNA     circular BCT 03-NOV-2012
DEFINITION  Staphylococcus aureus plasmid pUR2355, complete sequence.
ACCESSION   NC_019145
VERSION     NC_019145.1  GI:410655980
DBLINK      Project: 178791
            BioProject: PRJNA178791
KEYWORDS    .
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Firmicutes; Bacillales; Staphylococcus.
REFERENCE   1  (bases 1 to 7609)
  AUTHORS   Lozano,C., Aspiroz,C., Rezusta,A., Gomez-Sanz,E., Simon,C.,
            Gomez,P., Ortega,C., Revillo,M.J., Zarazaga,M. and Torres,C.
  TITLE     Identification of novel vga(A)-carrying plasmids and a Tn5406-like
            transposon in meticillin-resistant Staphylococcus aureus and
            Staphylococcus epidermidis of human and animal origin
  JOURNAL   Int. J. Antimicrob. Agents 40 (4), 306-312 (2012)
   PUBMED   22901706
REFERENCE   2  (bases 1 to 7609)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (03-NOV-2012) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 7609)
  AUTHORS   Lozano,C., Aspiroz,C., Rezusta,A., Ruiz-Garcia,M., Gomez-Sanz,E.,
            Aldea,M.J., Royo,G., Revillo,M.J., Zarazaga,M. and Torres,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2011) Area de Bioquimica y Biologia Molecular,
            Universidad de La Rioja, Madre de Dios, 51, Logrono, La Rioja
            26006, Spain
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to JQ312422.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..7609
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="C2355"
                     /isolation_source="pleural fluid"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="pUR2355"
                     /country="Spain"
     gene            622..1086
                     /locus_tag="D646_p6002"
                     /db_xref="GeneID:13914270"
     CDS             622..1086
                     /locus_tag="D646_p6002"
                     /note="initiator replication protein"
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein"
                     /protein_id="YP_006958117.1"
                     /db_xref="GI:410655986"
                     /db_xref="GeneID:13914270"
                     /translation="MKERYGTVYKGKEEFINKDSGEVIQFDKLYRAQTGGNFVKMYME
                     MFGQMLGLMNKRGEVMQYLFKDLNLSSNTVIKTVRELAKETNTSTKTVTETLKIMEKG
                     NIIKRKTGVIMINPALLMRGDDNKKRYLLLEFEQFNRENELEHALNEYESFK"
     gene            2170..3738
                     /gene="vga(A)"
                     /locus_tag="D646_p6001"
                     /db_xref="GeneID:13913682"
     CDS             2170..3738
                     /gene="vga(A)"
                     /locus_tag="D646_p6001"
                     /note="confers resistance to streptogramin A, lincosamides
                     and pleuromutilins"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter"
                     /protein_id="YP_006958118.1"
                     /db_xref="GI:410655981"
                     /db_xref="GeneID:13913682"
                     /translation="MKILLEGLHIKHYVQDRLLLNINRLKIYQNDRIGLIGKNGSGKT
                     TLLHILYKKIVPEEGIVKQFSHCELIPQLKLIESTKSGGEVTRNYIRQALDKNPELLL
                     ADEPTTNLDNNYIEKLEQDLKNWHGAFIIVSHDRAFLDNLCTTIWEIDEGRITEYKGN
                     YSNYVEQKELERHREELEYEKYEKEKKRLEKAINIKEQKAQRATKKPKNLSLSEGKIK
                     GAKPYFAGKQKKLRKTVKSLETRLEKLESVEKRNELPPLKMDLVNLESVKNRTIIRGE
                     DVSGTIEGRVLWKAKSFSIRGGDKMAIIGSNGTGKTTFIKKIVHGNPGISLSPSVKIG
                     YFSQKIDTLELDKSILENVQSSSQQNETLIRTILARMHFFRDDVYKPISVLSGGERVK
                     VALTKVFLSEVNTLVLDEPTNFLDMEAIEAFESLLKEYNGSIIFVSHDRKFIEKVATR
                     IMTIDNKEIKIFDGTYEQFKQAEKPTRNIKEDKKLLLETKITEVLSRLSIEPSEELEQ
                     EFQNLINEKRNLDK"
     gene            4261..4353
                     /locus_tag="D646_p6003"
                     /db_xref="GeneID:13914268"
     CDS             4261..4353
                     /locus_tag="D646_p6003"
                     /note="similar to pSHaeC02"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_006958119.1"
                     /db_xref="GI:410655982"
                     /db_xref="GeneID:13914268"
                     /translation="MIVVLFVMKYIVCPIIVGRVLYLLNQEHKR"
     gene            complement(4467..5333)
                     /locus_tag="D646_p6004"
                     /db_xref="GeneID:13914269"
     CDS             complement(4467..5333)
                     /locus_tag="D646_p6004"
                     /note="initiator replication protein"
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein"
                     /protein_id="YP_006958120.1"
                     /db_xref="GI:410655983"
                     /db_xref="GeneID:13914269"
                     /translation="MSGETVVYKNDMNLVPLRKFNNTEVNLFFTLCNKLKDKGNLTVN
                     VPFEELKELSNYYSHDKKLFIQDLEKFYDKIFSLTYREETENVIRKFILFTKVEIYKD
                     KEYVAIGVNPDLKHIINSLTSNFTKFELREMTHLKSTYSKHMFRILKQYKHTGYVKIK
                     IDDFRERLDIPNSYRMTNINQKVLAPIIKELGFIFNNLNINKIKAKRGRKIEWLEFTF
                     DAEKRIHNKRQPKMANVAQPKQYISREKTPKWLHERNQSNTTREMTEEEKALLKEQQQ
                     AFRQQLELDWED"
     gene            complement(6279..7244)
                     /gene="rlx"
                     /locus_tag="D646_p6005"
                     /db_xref="GeneID:13913680"
     CDS             complement(6279..7244)
                     /gene="rlx"
                     /locus_tag="D646_p6005"
                     /note="relaxase/mobilization nuclease domain; similar to
                     Staphylococcus hominis SK119"
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase protein"
                     /protein_id="YP_006958121.1"
                     /db_xref="GI:410655984"
                     /db_xref="GeneID:13913680"
                     /translation="MATTKLSATKSTSRAINYAEKRAVEKSGLNCDVDYAKSSFKASR
                     ELYGKTDGNQGHVIIQSFKPDEVTPEQCNQLGLELAEKLAPNHQVAVYTHNDTDHVHN
                     HIVINSIDLETGKKFNNNKQALRNVRNFNDEICREHGLSVPERDTAKLRYTQAEKALI
                     EKDQYSWKDDLREKIENAKDHTSDFKSFSEHLEKSGIEFKVRGKNVSYKPENVNKWVR
                     GKTLGEDYDKGALEYEFERREREEEKESERDAVAAYTDQFEVDWDAVEHNTEQLRKTR
                     IRRTEKTKQAHHQVSNRDTREPERTRERTKTTHIEFDRGDEGFSR"
     gene            complement(7226..7609)
                     /gene="mobC"
                     /locus_tag="D646_p6006"
                     /db_xref="GeneID:13913681"
     CDS             complement(7226..7609)
                     /gene="mobC"
                     /locus_tag="D646_p6006"
                     /note="bacterial mobilization protein (MobC)"
                     /codon_start=1
                     /transl_table=11
                     /product="mobilization protein"
                     /protein_id="YP_006958122.1"
                     /db_xref="GI:410655985"
                     /db_xref="GeneID:13913681"
                     /translation="MSEQNHFVASDETVGQNHKPNRKEPKQISFRVSESEYLKLKQSA
                     ETLNMSVPAFVKKKAQGSRLVAPKFDKETRQSIAKDLSRLGANANQIAKYCHQHQYNA
                     PNYSALERNINELRERLDDIWQQLN"
ORIGIN      
        1 acatcccacc acgctttcta cgaaagatat tacttaatat aaatttagat tatatgataa
       61 tctaaatttc atcaagtaat atagtggttt ggcaagcact ggctttgcta gccactcaat
      121 cgctatcgct cattcgtgac tgctcgcctg cttgttgggg gcaagccccc aaagccccct
      181 acaaaatgct agccatatat caaaaaataa acgtaagcat aaacgcattc acttcttttc
      241 tatataaata tgaacgaagt gaataagcgt cggaaaagca gcaaaaagtt tcctttttgc
      301 tgttggagca tgggggttca gggggtgcag tatctgacgt caatgccgag cgatagcgag
      361 ccgaagggta gcatttacgt tagataaccc cctgatatgc tccgacgctt tatatagaaa
      421 agaagattcg actaggtaaa atcttaatac aggctgatat aacaacgttt ataaggaatt
      481 ttgatgtagt acttttcttc ttgttttgta gtagttttct actacatacc ccttattttg
      541 aaactttttt ctactcaatg tgttgtatta tttttacaac ttatgtatta ttgagacata
      601 aaatataagt gaggtgtaac aatgaaagaa cgatatggaa cggtatataa agggaaagaa
      661 gagtttataa ataaagactc aggagaagta atacagtttg ataagctata tagagcacaa
      721 acaggtggaa acttcgtaaa gatgtatatg gaaatgtttg gacaaatgtt gggcttaatg
      781 aataaaagag gagaagtaat gcagtatctt tttaaagact taaacctatc aagcaataca
      841 gtaataaaaa cagttcgaga actcgctaaa gaaacaaata caagtacaaa aactgtaaca
      901 gaaaccctta aaattatgga aaaaggaaac attataaaaa gaaagactgg agttataatg
      961 ataaacccag ccttattaat gcgtggagat gataataaaa aacgttatct cttactagaa
     1021 ttcgagcaat tcaatagaga aaacgaatta gaacacgctt taaatgaata tgaaagtttt
     1081 aagtaagttc attataacaa ggaagtgaag taatgaataa tataaataca cttgagagac
     1141 gtttaaaaga cgctcagaga ataaaaaagt atctcataag gaataatgcc tcaaaaacta
     1201 aaataagcga aataaagcgt atagagaact tcttagatgt agaattaaac aaagaaaaaa
     1261 tagtagatac tttaaccaac gtatattttg gtaatcaaca aaatcaagat taaacctgca
     1321 cggttaatgc agatcaaaag cttaacgcaa atgaaataga ttgacctccc gataacacca
     1381 tgtggttatc gggaggtcaa tctatgaaat gcgattaagc ttttttctaa tttgcataag
     1441 cgtgcaggtt taaaacgcat aaaaagtata atgaaaaaaa gcatcattat actaacatta
     1501 tcccctcatt atatcgctat tatactcaca ttataatgac ccaccttaat ctcgctttat
     1561 tccaatttcc attttgagca gaaactttac tcatatgatt tggattggtt gttaagttgg
     1621 aattaatcca acttaaaacc ggcaccaatc gccactgaag tggctatcat attcgccttt
     1681 ctttctcaaa atgttttctc ggcataaatg cttgtttaag gtttggctag ccacatacgt
     1741 ggtagcgacg cctgcttgtt ggggaatatc cccaagcccc ttaggatttt tttctgcgaa
     1801 aaaataagtg tctaattgct agccactgtt cattaagtaa tataaataaa ttaaaaaaat
     1861 aatttgagtt gaacattgac atttatttgc tatttgttta aattgaattt aatacgataa
     1921 aggaaagggt gaaccaacta catgattaac taatcctatt ttcaaaagta aacaattgaa
     1981 agtgttttat ttacaaacag cgtttgattt gtgttgtttt caattgtact tttcaggata
     2041 ggatgaaaat tctgtagttg gctctaaaag tattttgtta gagttcatct atatagattt
     2101 atgcctccta ttctgaatag attgggaggc ttttattgtc ttaaattact tataagagga
     2161 tgagaaaata tgaaaatact gttagaggga cttcatataa aacattatgt tcaagatcgt
     2221 ttattgttga acataaatcg cctaaagatt tatcagaatg atcgtattgg tttaattggt
     2281 aaaaatggaa gtggaaaaac aacgttactt cacatattat ataaaaaaat tgtgcctgaa
     2341 gaaggtattg taaaacaatt ttcacattgt gaacttattc ctcaattgaa gctcatagaa
     2401 tcaactaaaa gtggtggtga agtaacacga aactatattc ggcaagcgct tgataaaaat
     2461 ccagaactgc tattagcaga tgaaccaaca actaacttag ataataacta tatagaaaaa
     2521 ttagaacagg atttaaaaaa ttggcatgga gcatttatta tagtttcaca tgatcgcgct
     2581 tttttagata acttgtgtac tactatatgg gaaattgacg aggggagaat aactgaatat
     2641 aaggggaatt atagtaacta tgttgaacaa aaagaattag aaagacatcg agaagaatta
     2701 gaatatgaaa aatatgaaaa agaaaagaaa cgattggaaa aagctataaa tataaaagaa
     2761 cagaaagctc aacgagcaac taaaaaaccg aaaaacttaa gtttatctga aggcaaaata
     2821 aaaggagcaa agccatactt tgcaggtaag caaaagaagt tacgaaaaac tgtaaaatct
     2881 ctagaaacca gactagaaaa acttgaaagc gtcgaaaaga gaaacgaact tcctccactt
     2941 aaaatggatt tagtgaactt agaaagtgta aaaaatagaa ctataatacg tggtgaagat
     3001 gtctcgggta caattgaagg acgggtattg tggaaagcaa aaagttttag tattcgcgga
     3061 ggagacaaga tggcaattat cggatctaat ggtacaggaa agacaacgtt tattaaaaaa
     3121 attgtgcatg ggaatcctgg tatttcatta tcgccatctg tcaaaatcgg ttattttagc
     3181 caaaaaatag atacattaga attagataag agtattttag aaaacgttca atcttcttca
     3241 caacaaaatg aaactcttat tcgaactatt ctagctagaa tgcatttttt tagagatgat
     3301 gtttataaac caataagtgt tttaagtggt ggagagcgag ttaaagtagc actaactaaa
     3361 gtattcttaa gtgaagttaa tacgttggta ttagatgaac caacaaactt tcttgatatg
     3421 gaagctatag aggcgtttga atctttgtta aaggaatata atggcagtat aatctttgta
     3481 tctcacgatc gtaaatttat cgaaaaagta gccactcgaa taatgacaat tgataataaa
     3541 gaaataaaaa tatttgatgg cacatatgaa caatttaaac aagctgaaaa gccaacaagg
     3601 aatattaaag aagataaaaa acttttactt gagacaaaaa ttacagaagt actcagtcga
     3661 ttgagtattg aaccttcgga agaattagaa caagagtttc aaaacttaat aaatgaaaaa
     3721 agaaatttgg ataaataaat tactttaaat ttaagcaata aagattattc ttgttgtctt
     3781 tttattgaat aattgatggg taatatttat taagttagcg tattgcataa catatacaat
     3841 tcaactaccc ataagagtta attatgttaa ctaactcaaa aggcttaaac gttgatttaa
     3901 caacgtttaa gccttttgct tatcattatc gtttatgcag gttttataca tcattgatct
     3961 gatgcgtttt cagtcatttt cattgatgat cggtttgtat ctttattcag tttacacttg
     4021 tgtaaattac acaagtgtaa actacacaaa tcattattca tgcggatact agttgactag
     4081 taaataagta aacaagtaaa caagtttact tgtttacctg taattgatat atcgtattta
     4141 gatgttacat acaatatgcg tgcacacagt atgcttgcat attgtatgca cgcatacagg
     4201 tcatagggat tttgttataa ttggagagca cttccgtgca gaaaggaggt gccacatcta
     4261 atgattgtcg ttctgtttgt tatgaagtat atcgtatgtc caattattgt tggacgtgtt
     4321 ctttatttat taaatcaaga acataaacga taaaaaagaa accccagcat atgctttggt
     4381 cggcatgctg gggttttcac atctaatgat gtatctgtct gtttgttaat ttcagtatat
     4441 ctttcatagt atcttttgta aactttctaa tcttcccaat ctagttctaa ttgttgtcta
     4501 aatgcttgtt gttgttcttt taatagtgct ttttcttctt cagtcatttc tctagttgta
     4561 ttactttgat ttcgttcatg tagccatttt ggcgttttct cacgactgat atattgtttg
     4621 ggttgggcta cattcgccat tttgggttgt cgcttgttgt gaatgcgttt ctcagcgtca
     4681 aaagtaaact ctaaccactc gattttacgt cctcttttcg cttttatttt attgatatta
     4741 aggttattaa aaatgaatcc taattcttta atgatagggg ctaatacttt ttgattaata
     4801 tttgtcatac ggtagctatt aggaatatct agccgttctc taaaatcatc aattttaatt
     4861 tttacatagc cagtatgttt atactgctta agtattctga acatatgctt agaatatgta
     4921 gatttaaggt gtgtcatttc tcgaagttca aatttagtga agttactagt taatgaatta
     4981 ataatatgtt ttaaatctgg attaacacca atagccacat actctttatc tttataaatt
     5041 tctactttag taaaaagaat aaattttcta ataacattct cagtttcttc tctatatgtt
     5101 aaagagaaga ttttatcata gaatttttct aaatcttgaa taaaaagctt tttatcatga
     5161 ctatagtaat tacttaattc ttttaattct tcaaatggca cattaacagt caaattgcct
     5221 ttatctttta atttattaca caaagtaaaa aatagattaa cttcggtatt attaaatttt
     5281 ctcaatggaa ctaaattcat atcattttta tatactactg tttctccact caattaactc
     5341 cactccaatc taaaagaaac cttcacacaa taaagattcc tattaacttt aattataaat
     5401 acttataatc gctatattat aagtaataat aacataaaga aacctaatat aaaaaatagt
     5461 tcctttagtt taatgattgg ttgcctttaa catttcaaat ccgttgtcgc tctaaggctc
     5521 aaaagccacc taaaaaggtt ttaaaaagat ttataaaaag atattaaaaa gttcggggca
     5581 ttttgcccct cacaaattca aaagacaaaa aggaaagcaa ccacaaaagt ggttgctctt
     5641 ttatttataa aaatcattaa gttattaccc tttgatgcat tattccaatt gctttattga
     5701 cattgagcct ctgaaccctt aataaaccct aaaactgtcg actcgtcggt tttatagctc
     5761 acgctatacc gacattcgtc gaaacagttt aattaagggt tcttctcaat gcacaataaa
     5821 ttttctcggc ataattgcgt cctcataatt acaaaaagac ttcgaatttc tttctaatcc
     5881 attcataaag ataaataaat ccacctatcg caatgatata cggtaagcca taagcaatgt
     5941 accaaaccaa cgtcataaag ccctcagacg ttttaatctt actagctatt gctttttgaa
     6001 gtatatcgac atgtataaaa tccataaaat cactaccaat agtcatgact aacgtaaaaa
     6061 gcataaagac taataacatt atgccaattc ctcgatacat gagtttaatt ttcttttggt
     6121 atgcttcatg tgacgctctc acttcttgca acatacgttc attttcatca cgcactttat
     6181 aaatatctct gccgattata ttagctaatt catcggtatc gactttatcc aatttttctt
     6241 taagtatatg agtaaagcta ttatggactt taacaccatt atctcgaaaa tccttcgtcg
     6301 cctctgtcaa attcgatgtg agttgttttt gttctttctc tcgtgcgttc tggttctctt
     6361 gtatctctgt tagatacttg atgatgagct tgttttgttt tttcagttcg tctaattctt
     6421 gtctttctaa gttgttctgt gttgtgttcg acggcgtccc agtcaacttc gaattggtct
     6481 gtgtacgctg cgactgcgtc tcgctctgat tccttttctt cttctctttc tcgtctttca
     6541 aactcatatt ctaacgcccc cttgtcgtaa tcttcgccaa gtgttttgcc acgtacccat
     6601 ttattgacgt tttcaggctt atatgagacg tttttgcctc tgactttaaa ctcgataccg
     6661 gatttctcta aatgctctga aaagctctta aaatcacttg tatggtcttt cgcattttca
     6721 attttttctc gtaaatcatc tttccaagaa tattgatctt tttctattaa tgctttttca
     6781 gcttgggtat atcttaattt tgcagtatca cgttctggca cacttaaacc gtgttcccga
     6841 caaatctcat cattaaaatt tctgacatta cgtaaggctt gtttattgtt gttgaatttc
     6901 ttacctgtct cgaggtcaat cgaattaatc acgatatggt tgtgtacatg atccgtatca
     6961 ttatgtgtgt acacagccac ttgatgattg ggtgctagtt tttcagcgag ttctaaacct
     7021 aactgattac attgttctgg agttacttca tcgggtttga atgattgaat aatcacatga
     7081 ccttgattac catcagtttt gccatataac tcacgtgagg ctttaaaact cgatttcgca
     7141 taatccacat cacaatttaa gccgcttttt tcaacagcac gtttctcagc gtaattaatg
     7201 gcacgtgacg ttgatttcgt cgcacttaat ttagttgttg ccatatgtca tccaaccttt
     7261 cacgtaattc attgatatta cgttctaatg cgctataatt cggagcgtta tattggtgtt
     7321 gatgacaata tttcgcaatt tgattggcat ttgcccctaa tcgacttaaa tctttcgcaa
     7381 tcgattgtct cgtttcttta tcaaatttag gtgcgaccaa tcgactgcct tgtgcctttt
     7441 tcttaacgaa agcaggcaca ctcatattta aagtttcagc cgactgcttc aactttaaat
     7501 attcggattc gctcacacga aaactaattt gtttcggctc cttacggttg ggtttatggt
     7561 tttgcccaac agtttcgtcg ctagccacaa aatggttttg ttcgctcat
//
