LOCUS       NC_013516              10702 bp    DNA     circular CON 08-JUN-2013
DEFINITION  Streptobacillus moniliformis DSM 12112 plasmid pSMON01, complete
            sequence.
ACCESSION   NC_013516
VERSION     NC_013516.1  GI:268687599
DBLINK      Project: 41863
            BioProject: PRJNA41863
KEYWORDS    .
SOURCE      Streptobacillus moniliformis DSM 12112
  ORGANISM  Streptobacillus moniliformis DSM 12112
            Bacteria; Fusobacteria; Fusobacteriales; Leptotrichiaceae;
            Streptobacillus.
REFERENCE   1  (bases 1 to 10702)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Dalin,E.,
            Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Kyrpides,N.,
            Mavromatis,K., Ivanova,N., Ovchinnikova,G., Sims,D., Meincke,L.,
            Brettin,T., Detter,J.C., Han,C., Larimer,F., Land,M., Hauser,L.,
            Markowitz,V., Cheng,J.-F., Hugenholtz,P., Woyke,T., Wu,D.,
            Gronow,S., Sproer,C., Goker,M., Rohde,M., Klenk,H.-P. and
            Eisen,J.A.
  CONSRTM   US DOE Joint Genome Institute (JGI-PGF)
  TITLE     The complete plasmid of Streptobacillus moniliformis DSM 12112
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10702)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (18-NOV-2009) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 10702)
  AUTHORS   Lucas,S., Copeland,A., Lapidus,A., Glavina del Rio,T., Dalin,E.,
            Tice,H., Bruce,D., Goodwin,L., Pitluck,S., Kyrpides,N.,
            Mavromatis,K., Ivanova,N., Ovchinnikova,G., Sims,D., Meincke,L.,
            Brettin,T., Detter,J.C., Han,C., Larimer,F., Land,M., Hauser,L.,
            Markowitz,V., Cheng,J.-F., Hugenholtz,P., Woyke,T., Wu,D.,
            Gronow,S., Sproer,C., Goker,M., Rohde,M., Klenk,H.-P. and
            Eisen,J.A.
  CONSRTM   US DOE Joint Genome Institute (JGI-PGF)
  TITLE     Direct Submission
  JOURNAL   Submitted (01-OCT-2009) US DOE Joint Genome Institute, 2800
            Mitchell Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to CP001780.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4083288
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Jonathan A. Eisen (jaeisen@ucdavis.edu)
                      David Bruce (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Finishing done by JGI-LANL
            Annotation by JGI-ORNL and JGI-PGF
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            
            ##Metadata-START##
            Organism Display Name :: Streptobacillus moniliformis 9901, DSM
                                     12112
            Culture Collection ID :: DSM 12112, ATCC 14647
            GOLD Stamp ID         :: Gi02312
            Funding Program       :: DOE-GEBA 2007
            Number of Reads       :: 22979 Sanger, 326576 pyrosequence
            Assembly Method       :: Newbler version 1.1.02.15, Phrap
            Sequencing Depth      :: 11.5x Sanger; 24.9x pyrosequence
            Gene Calling Method   :: Prodigal 1.4, GenePRIMP
            Isolation Site        :: Patient with rat-bite fever in France
            Isolation Country     :: France
            Host Name             :: Homo sapiens
            Host Health           :: Patient with rat-bite fever
            Oxygen Requirement    :: Facultative
            Cell Shape            :: Rod-shaped
            Motility              :: Nonmotile
            Sporulation           :: Nonsporulating
            Temperature Range     :: Mesophile
            Temperature Optimum   :: 37C
            Gram Staining         :: gram-
            Biotic Relationship   :: Free living
            Diseases              :: Endocarditis, Haverhill fever, Rat-bite
                                     fever
            Habitat               :: Host
            Phenotypes            :: Pathogen
            ##Metadata-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..10702
                     /organism="Streptobacillus moniliformis DSM 12112"
                     /mol_type="genomic DNA"
                     /strain="DSM 12112"
                     /culture_collection="DSMZ:DSM 12112"
                     /db_xref="taxon:519441"
                     /plasmid="pSMON01"
     gene            complement(4..1920)
                     /locus_tag="Smon_1504"
                     /db_xref="GeneID:8593865"
     CDS             complement(4..1920)
                     /locus_tag="Smon_1504"
                     /inference="ab initio prediction:Prodigal:1.4"
                     /note="KEGG: viral A-type inclusion protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_003306812.1"
                     /db_xref="GI:268687600"
                     /db_xref="GeneID:8593865"
                     /translation="MSIAKQVKIFSNFKKKSTKVSGSRQQIIDIAGEYERIGEQKNPD
                     INLKLSGENIILKKFDLEEYDNYILNTDYSLNKDTSKFEDFYSTTPTIQATNFVNLGG
                     INLTFLASKDEWTEFYKDVSQFIKNYMGEDYRILSEVIQFDEFTPHLQIMGIYRTEIK
                     SSDEKDIRNDKELFEKVASNKFTRYNSSLKGQENYTDPKSKKLYKHAKEKWIEENREE
                     IIKSYKPRNKKTDMKYCFTTTKTIAAKSNSYQDYQNKLFNFCKEHKFIKELCKKATEI
                     RGEEVEFVKNSTEKVYDGKSKDHYEIKETIERENKNIEKKILKREPLTEIEMYRYIRK
                     RNREKLKEEFMELDKEEWRELFNKKIETKFDFNAKIQHDYIALAKEIEYKEYLKLEEE
                     KLKAQKEKEESIIENKKIIEDLKSQKNELQQVKDEKENIRGQITKFTNTDKWVNIQML
                     EKIYNEKSEHKKGMFDSTPMITTTKENYEYIFRMAKDNSSKLSSFKNSLAEKEFLIAN
                     LKEKYQRLEEIKNSELNSKNEKIKQLESTIRLRDNEITNLKQEKKKIEKELDEVKGEL
                     TWYKRTLNVIQNVMKYVPNLKKIVDKIIDKVSNLSNYYDENNATKEINVELGFEEPES
                     AWNKIKTQGKTLER"
     gene            complement(2336..3124)
                     /locus_tag="Smon_1505"
                     /db_xref="GeneID:8593858"
     CDS             complement(2336..3124)
                     /locus_tag="Smon_1505"
                     /inference="protein motif:PFAM:PF06182"
                     /note="PFAM: protein of unknown function DUF990;
                     KEGG: bcy:Bcer98_0456 hypothetical protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_003306813.1"
                     /db_xref="GI:268687601"
                     /db_xref="InterPro:IPR010390"
                     /db_xref="GeneID:8593858"
                     /translation="MKRYLKLFFLYLYINIKELKSYGIDFYLGSIAMFLKNISNLFLI
                     FFIYNIVNVINGWNINEMIYLYSIVTISFSIWRCFFINTLNISYYIINGKLDILLIKP
                     LNPLFLIFMEGFDEDAWGDLAVGIIIYFYISFKLNLPILNIILVFIIALLGGLVFSGI
                     SVIGSLFSIIFLGSSNFSDLPYIIYEFSKYPINIFNPVISILFKTIIPVAWIGYIPAY
                     INLKDGNQNLIIVFLISVFITILYFIIVVLIWNNVLKKYSSSGT"
     misc_feature    complement(2339..>2944)
                     /locus_tag="Smon_1505"
                     /note="ABC-2 family transporter protein; Region:
                     ABC2_membrane_6; cl01496"
                     /db_xref="CDD:242535"
     gene            complement(3126..3890)
                     /locus_tag="Smon_1506"
                     /db_xref="GeneID:8593859"
     CDS             complement(3126..3890)
                     /locus_tag="Smon_1506"
                     /inference="protein motif:PFAM:PF06182"
                     /note="PFAM: protein of unknown function DUF990; ABC-2
                     type transporter;
                     KEGG: bar:GBAA0533 ABC transporter permease"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="YP_003306814.1"
                     /db_xref="GI:268687602"
                     /db_xref="InterPro:IPR010390"
                     /db_xref="InterPro:IPR013525"
                     /db_xref="GeneID:8593859"
                     /translation="MDKYIELIKIGGKKILSYKGLITTLIIKNYIYIFLQYSLWLSIK
                     ENSSINIDIKNILVYFIIIRSVNSVNFNLSQYMSYDVKNGNIVGILTKPITVEKYYFF
                     DILGNTIAKVLAILIPNILIALFLIGKFNIFFIFKLIIIIIGSYVLNFVIELILGTFS
                     FFTQSIWGIESLKSIFMLILSGSFFPIEYYPEWSKKMLDYNPFVYIYGKIADFILYEK
                     NFLKILFFQTFFVLILFCVYKSIFKLCLKKISINGG"
     misc_feature    complement(3129..>3458)
                     /locus_tag="Smon_1506"
                     /note="ABC-type uncharacterized transport system, permease
                     component [General function prediction only]; Region:
                     COG4587"
                     /db_xref="CDD:226953"
     gene            complement(3883..4827)
                     /locus_tag="Smon_1507"
                     /db_xref="GeneID:8593860"
     CDS             complement(3883..4827)
                     /locus_tag="Smon_1507"
                     /inference="protein motif:PFAM:PF00005"
                     /note="PFAM: ABC transporter related;
                     SMART: AAA ATPase;
                     KEGG: gox:GOX2157 ABC transporter ATP-binding protein"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="YP_003306815.1"
                     /db_xref="GI:268687603"
                     /db_xref="InterPro:IPR002048"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="GeneID:8593860"
                     /translation="MEKIISINNLNKVYKIKKGFFSRSEIKTIQALKNINLEIYKGQT
                     VGLIGLNGAGKSTLIKIILGILVPTEGEIKVFDKEPFENRIENLYNIGVIFGQKTQLR
                     WDLSPLDSYKLNKALYDIPGEKFETLLNKYSEILELNSFIDRPVRTLSLGQKMRADLL
                     SALLHSPELLILDEATIGVDILSKNKILKLIEELKKDTTIIYTSHNLNEVYEISDRII
                     ILNKGEIVLDKNKDDILNDIEYLSIKIYLKSPLKYDSLKFREVKISKTNEYEYNFEFI
                     RKDELKNFLDYIYLNNLIDYFEIKENNLEKILKEVSNG"
     misc_feature    complement(3907..4827)
                     /locus_tag="Smon_1507"
                     /note="ABC-type multidrug transport system, ATPase
                     component [Defense mechanisms]; Region: CcmA; COG1131"
                     /db_xref="CDD:224054"
     misc_feature    complement(4144..4815)
                     /locus_tag="Smon_1507"
                     /note="ATP-binding cassette transporter nucleotide-binding
                     domain; Region: ABC_ATPase; cl17201"
                     /db_xref="CDD:247755"
     misc_feature    complement(4660..4683)
                     /locus_tag="Smon_1507"
                     /note="Walker A/P-loop; other site"
                     /db_xref="CDD:213179"
     misc_feature    complement(order(4213..4215,4306..4311,4537..4539,
                     4657..4665,4669..4674))
                     /locus_tag="Smon_1507"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:213179"
     misc_feature    complement(4537..4548)
                     /locus_tag="Smon_1507"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:213179"
     misc_feature    complement(4354..4383)
                     /locus_tag="Smon_1507"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:213179"
     misc_feature    complement(4306..4323)
                     /locus_tag="Smon_1507"
                     /note="Walker B; other site"
                     /db_xref="CDD:213179"
     misc_feature    complement(4288..4299)
                     /locus_tag="Smon_1507"
                     /note="D-loop; other site"
                     /db_xref="CDD:213179"
     misc_feature    complement(4207..4227)
                     /locus_tag="Smon_1507"
                     /note="H-loop/switch region; other site"
                     /db_xref="CDD:213179"
     gene            complement(4828..6429)
                     /locus_tag="Smon_1508"
                     /db_xref="GeneID:8593861"
     CDS             complement(4828..6429)
                     /locus_tag="Smon_1508"
                     /inference="ab initio prediction:Prodigal:1.4"
                     /note="KEGG: hypothetical protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_003306816.1"
                     /db_xref="GI:268687604"
                     /db_xref="GeneID:8593861"
                     /translation="MINKFKNLIKYIEYHIIYFDKKKYIYLDETNMKLVFLSKKNNLK
                     FSLTNAEFFYKQGQNYLYIISLNSNILLIKKINFHFKIQIKLYNLNRYYKERLEISNI
                     FINENNELILFLEPINKYLIIGSKLRFKNKLFKKLISNKEYDFKYIDLVKRIYILKNE
                     NNNYESNLLDKLYYYIGIYNQIFIIVEKFIDYFIIKIIKLKKNIKSNKILGVISDILS
                     FNNNIFIKYVFSGMTFCIHIDLLNLSEKLIINELKGKVNLYNFIDNKLIYKIDSLLFG
                     EIIINKSSNYRNNIILRKYIYKDRIKIKEYYSENLKYISIFKDLNKEEEITLISCHGG
                     PESFELLSNNYGGLYYKLLKEFPIKIIIFNYPGSISFGSEYRKLPYNDWKNVLNKSLN
                     KLLEEDKTKKILIGGSFGGTVSLLIENSQIKNKILINPLLDLNNHIESIPTSYNKWFY
                     KRFSNKDFRDINLNNILNLNLNKNLYFILGYNDEIINKRNILENSFQSKNFRFFWDEG
                     THNSNLKARSSRMFEIIKKIYKEGK"
     gene            complement(6419..7927)
                     /locus_tag="Smon_1509"
                     /db_xref="GeneID:8593862"
     CDS             complement(6419..7927)
                     /locus_tag="Smon_1509"
                     /inference="protein motif:PFAM:PF07719"
                     /note="PFAM: Tetratricopeptide TPR_2 repeat protein; TPR
                     repeat-containing protein;
                     SMART: Tetratricopeptide domain protein;
                     KEGG: SLEI family protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_003306817.1"
                     /db_xref="GI:268687605"
                     /db_xref="InterPro:IPR001440"
                     /db_xref="InterPro:IPR013026"
                     /db_xref="InterPro:IPR013105"
                     /db_xref="GeneID:8593862"
                     /translation="MVELIVKDKILISFLGLKTIIYKLKMLEIEKNLEFKRACKILNL
                     KFNDENLKFSLTSSAKIQNQIRFYTKNKIKREIIKIIKYIIRNYKNLSISINNYDKLD
                     EGTKLFFNIFEELFPNNIKIIIENTDKDENIIYTDQEKEINYYLKNNFADKNVIEFLI
                     KQTEYYLNIGDYYTALSILNFIEKKETSVKLYTLFSIAYNMKEDTIKSEYYLKKWYSY
                     GSYEDKASCLYSLSILQARHMETYRRDYNLGLKYINEGYEILNNLRKPDNTRIEINKI
                     FNRNGYAFFLFNDKKYDEAIELVKKLIEELEKFDINKTLLQKTVLLFNLGQCYTKANY
                     LKEAIETYKKLILLDPYFAEYHIELSKLFLKNEQIEEALNELEIALDLDSTIPEIYSL
                     KGFISLKNEDLKEAIFNYKEAYILDKNIEIIYDYIYILSENNEYKEALNIINNLNNYQ
                     KTDNIDIISLISEVYYNNDLREKAIELLNEGIRKFENNKILLENLEIIKYDK"
     misc_feature    complement(<6833..6979)
                     /locus_tag="Smon_1509"
                     /note="TPR repeat; Region: TPR_11; pfam13414"
                     /db_xref="CDD:222112"
     misc_feature    complement(6671..6967)
                     /locus_tag="Smon_1509"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:238112"
     misc_feature    complement(order(6728..6733,6740..6745,6752..6757,
                     6833..6838,6845..6850,6854..6859,6944..6949,6956..6961,
                     6965..6967))
                     /locus_tag="Smon_1509"
                     /note="binding surface"
                     /db_xref="CDD:238112"
     misc_feature    complement(order(6689..6691,6698..6700,6710..6712,
                     6746..6748,6791..6793,6800..6802,6812..6814,6848..6850,
                     6893..6895,6902..6904,6914..6916,6950..6952))
                     /locus_tag="Smon_1509"
                     /note="TPR motif; other site"
                     /db_xref="CDD:238112"
     gene            complement(8179..8634)
                     /locus_tag="Smon_1510"
                     /db_xref="GeneID:8593863"
     CDS             complement(8179..8634)
                     /locus_tag="Smon_1510"
                     /inference="ab initio prediction:Prodigal:1.4"
                     /note="KEGG: hypothetical protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_003306818.1"
                     /db_xref="GI:268687606"
                     /db_xref="GeneID:8593863"
                     /translation="MKFTYKEYMALKGIKSRNTLKKYVREGSVKEVKGEDGKLYIIDT
                     QIDTSLIPFETQSIKSAPKIDSQNDIIKLLNFETENQNKKIKELEQEIKILNIQLENK
                     NNFISRMEEEIKEDKLNYQRLFEQISETNKTYQLLLENKKNKKWYQIWK"
     gene            complement(8710..10146)
                     /locus_tag="Smon_1511"
                     /db_xref="GeneID:8593864"
     CDS             complement(8710..10146)
                     /locus_tag="Smon_1511"
                     /inference="ab initio prediction:Prodigal:1.4"
                     /note="KEGG: cjj:CJJ81176_pTet0001 hypothetical protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="YP_003306819.1"
                     /db_xref="GI:268687607"
                     /db_xref="GeneID:8593864"
                     /translation="MSNKNVEYLTIEDKIQNFNEKNLFLEYNDIFDLDRIDLYGFYEF
                     VFMRNNEYPFELKGKENYVEGQYNSIIVNIKKEKSFSKIITRDLEELPEFEGQDFVIT
                     SPITYIGRNRNSNNARYCYGIAFDIDGVFLSNLQDLLHQMRTKRLPIANLIVNSGNGV
                     HLYYLFEKPIALFDNIKVLLKDFKYKLTVEIWNMYTSSISEKQVQGIFQGFRLPGTKT
                     KFGEIVTAFKFNDIPYATIEYLNNFIYEEKKRLTMDQIAMINKSTYRHSKISLEKAKE
                     LYPDWYERRIVKGEKRGKWNIKRDLYDWWLNKIKGNEVKEGHRYFCLMSLAMYAIKCN
                     IDYEELKKDSYSLLAPMENLTMNEDNHFTKEDIEDSLKAFRENYSTFPRKDIEKITGI
                     IIPPNKRNGRKQKEHLLRARILQNLDFPNGEWRNKNGKPIGEGTKENIVIEYKKNNPN
                     ATMYRCQKETGLSKNTVKKYWNLIEIEV"
     misc_feature    complement(<8737..8949)
                     /locus_tag="Smon_1511"
                     /note="Family A polymerase primarily fills DNA gaps that
                     arise during DNA repair, recombination and replication;
                     Region: DNA_pol_A; cl02626"
                     /db_xref="CDD:243116"
ORIGIN      
        1 ggcttatctc tctaatgttt tcccttgtgt cttaatttta ttccatgcag attcaggttc
       61 ttcaaatcct aattcaacat ttatttcttt tgttgcatta ttttcatcat aataatttga
      121 taaattagat actttatcaa ttatcttatc aactattttc tttaaatttg gtacatattt
      181 cattacattt tgaattacat ttaaagttct tttataccaa gtcaattctc cttttacctc
      241 atctaattct ttttcaatct ttttcttttc ttgttttaaa ttggttattt cattatctct
      301 taatcttata gttgattcta attgcttaat tttttcattt ttactattta attcagagtt
      361 ttttatttct tctaatcttt gatatttttc ttttaaatta gctattaaaa attccttttc
      421 tgctaaacta tttttaaatg aacttaattt gctagaattg tcttttgcca ttctaaaaat
      481 atattcataa ttttcttttg ttgtagttat cattggtgta ctatcaaaca ttcctttttt
      541 atgttctgat ttttcattat atatcttttc tagcatttga atatttaccc atttatcagt
      601 attagtaaat tttgttattt gtcccctaat attttctttt tcatctttaa cttgttgcaa
      661 ttcatttttt tgacttttaa gatcctctat tattttttta ttttcaatta tactttcttc
      721 tttttctttt tgtgctttca gtttttcttc ttcaagtttt aaatactctt tatattctat
      781 ttcttttgct agtgctatat agtcgtgttg tatcttagca ttaaaatcaa atttagtctc
      841 tattttctta ttaaaaagtt ctctccattc ttctttatct agttccataa attcttcttt
      901 taacttttct ctatttcttt ttcttatgta tctatacatt tcaatttcag ttagtggttc
      961 tctttttaaa attttctttt caatattttt attttctctt tctattgttt ctttaatctc
     1021 gtaatggtct tttgatttac catcatatac tttctcagta gaatttttta caaactctac
     1081 ctcttcccct cttatttcag ttgctttctt acataactct ttaataaatt tatgctcttt
     1141 acaaaaatta aaaagtttat tttgataatc ttgatatgaa ttagatttag cagcaatagt
     1201 ctttgttgta gtaaagcaat atttcatatc agttttttta tttcttggct tgtatgattt
     1261 tattatttct tctctatttt cttcaatcca tttttctttt gcgtgtttat ataatttttt
     1321 acttttagga tccgtataat tttcttgtcc ttttaaactg ctattgtatc ttgtgaactt
     1381 attacttgcc accttttcaa ataattcttt atcgtttcta atgtctttct catcactaga
     1441 ttttatttca gttctatata ttcccattat ctgcaagtgt ggagtaaatt catcgaattg
     1501 tatcacttct gatagaattc tataatcttc ccccatataa ttttttataa attgagaaac
     1561 atctttataa aactccgtcc actcatcttt acttgctaaa aaagttaaat tgattccacc
     1621 taaatttaca aagttggttg cttgaattgt aggtgtcgta gagtaaaaat cttcaaattt
     1681 actggtatct ttatttaaac tataatctgt atttaaaatg taattatcat attcttcaag
     1741 atcaaacttt tttagaataa tattctcccc agataatttt agatttatgt ctggattctt
     1801 ctgttctcca atcctttcat actcacctgc aatgtcaata atttgttgcc gacttccaga
     1861 aacttttgtt gactttttct taaaatttga aaatattttg acttgttttg ctattgacat
     1921 cttcaatcac tcctttaaag tttacactta gtagtttttt ttaatttttg acatttcgcc
     1981 ataaaatcgg aataataatt tttgataaaa ttttgaattt tttgcttaat ttttgtagta
     2041 cagttagaga caagttgttt ctgactaaaa atttatcgca aaaaacacat caaaatttgt
     2101 tccaatactc tgcaaatttt tcaaatttgc aatttttact ggaatttatt aatttccagt
     2161 aaaaataaag gggtcaaggg gctcccttgc acgttaaatg tcaaggtaaa acggcttgcg
     2221 tttccttgca ttataacgtg ctataataca atatgataag aatttttaaa aagggaaaaa
     2281 tattcccttt attttatatt cattatttat aagtttaatt acctaaagaa atatactaag
     2341 tacctgaact cgaatacttc tttaatacat tattccaaat taatactact attataaaat
     2401 ataatattgt aataaaaact gaaattaaaa atacaattat caaattttga ttaccatctt
     2461 ttaaatttat gtatgctggt atataaccga tccatgcaac cggaataatt gttttaaata
     2521 aaatagaaat tacaggatta aaaatattta ttggatattt agaaaattca tatattatat
     2581 atggtaaatc tgaaaaatta gatgacccca aaaatataat tgaaaacaat gaccctatta
     2641 ctgatatgcc tgaaaacact aatcccccta ataaagctat tataaatact aaaataatat
     2701 tcagtatcgg taaatttaat ttaaatgata tatagaaata tataataata ccaactgcta
     2761 aatctcccca cgcatcttca tcaaagcctt ccataaaaat taaaaataaa ggattcaaag
     2821 gttttataag taatatatct aatttaccat ttattatata atatgatata tttagagtat
     2881 ttataaaaaa acatctccag attgaaaaac taattgtaac tatagaatat aaatatatca
     2941 tttcattaat attccaaccg tttattacat taacaatatt atatataaaa aatatcaaaa
     3001 atagattaga tatatttttt aaaaacatcg caattgaacc taaataaaaa tctattccat
     3061 aagattttaa ttcttttata ttaatatata aatataaaaa aaatagtttt aaatatcttt
     3121 tcattttatc ctccatttat actaattttc tttaaacata atttaaaaat agatttatat
     3181 acacaaaata aaatcaatac aaaaaaagtt tgaaaaaata atatctttaa aaaatttttt
     3241 tcatataata taaaatctgc tatctttcca tatatatata caaaaggatt ataatctaac
     3301 attttctttg accattctgg ataatattct atggggaaaa atgaccctga aagtataagc
     3361 ataaatatag actttaaaga ttcaattccc cagatacttt gtgtaaaaaa agagaatgtc
     3421 cctaaaatta attctataac aaaattaagt acatatgaac ctattattat aataattaac
     3481 ttaaatataa aaaatatatt aaatttccca atcaaaaaca aagctattaa tatattagga
     3541 attaaaatcg ctaaaacttt agcaatagta tttcctaata tatcaaaaaa ataatatttt
     3601 tctacagtaa ttggttttgt taatatccct actatattac cattttttac atcataactc
     3661 atatattgag ataaattgaa attaacacta ttaacagatc taataattat aaaataaact
     3721 aatatatttt ttatatcaat atttattgag ctattttctt ttatcgatag ccataaacta
     3781 tattgtaaaa atatataaat ataatttttt ataattaaag ttgttattaa gcctttatat
     3841 gataatattt tttttccccc tattttaatt aactctatat atttatccat tagaaacttc
     3901 ctttaatatt ttttctaaat tattttcttt aatttcaaaa taatcaatca aattattcaa
     3961 gtaaatataa tctaagaaat tttttaattc atcttttctt ataaattcaa aattatattc
     4021 atactcattt gttttactta tttttacttc tctaaatttt aaactatcat acttaagtgg
     4081 acttttaaga taaattttta tacttaaata ttcaatatca tttaaaatat catctttatt
     4141 tttatccaat acaatttcac ctttatttaa aattattatt ctatctgaaa tttcataaac
     4201 ttcatttaaa ttatgtgaag tatatattat tgttgtatct ttttttaatt cttctattaa
     4261 ttttaaaatt ttatttttac ttaatatatc tacaccaata gttgcttcat ctaaaattaa
     4321 taattcagga gaatgtaata atgccgataa taaatctgct ctcatttttt gtcctaaact
     4381 taaagtccta acaggcctat cgataaaaga atttaattct aatatttcag aatacttatt
     4441 taataaagtt tcaaattttt cgccaggtat atcatataaa gctttattca atttataaga
     4501 atctaaggga gataaatccc atcttaattg tgttttctgt ccaaaaataa caccaatgtt
     4561 atataaattt tcaattctat tttcaaaagg ttctttatca aaaactttta tttctccttc
     4621 ggttggaaca agtattccta aaataatttt tattaaagta gatttacctg ccccatttaa
     4681 acctataagt cctactgttt gtcctttata aatttctaaa tttatatttt ttaaagcttg
     4741 tattgtttta atctcacttc tagaaaaaaa tccttttttt attttataaa ccttatttaa
     4801 attatttata cttataattt tctccattta ttttccttct ttgtaaattt tttttataat
     4861 ttcaaacatt ctgctacttc tagcttttaa attagaatta tgtgttcctt catcccaaaa
     4921 aaatctgaaa tttttagatt gaaaagaatt ttctaatata tttcttttat taataatttc
     4981 atcattataa ccaagtataa aatataaatt cttgttcaag tttaaattta aaatattatt
     5041 taaatttata tctctaaaat ctttatttga aaatctttta taaaaccatt tattataact
     5101 tgttggtata ctctctatat gattatttaa atcaagtaat ggatttatta aaattttatt
     5161 tttaatttgg gaattttcta ttaataatga tactgtcccc ccaaagcttc cacctattag
     5221 tattttttta gttttatctt cttctaataa tttatttaat gatttattta aaacattctt
     5281 ccaatcatta tatggtaatt tcctatattc acttccaaat gaaattgaac ctggataatt
     5341 aaatattata atttttattg gaaattcctt taaaagctta tagtataatc caccataatt
     5401 atttgaaagt aattcaaaac tctcagggcc accatgacat gatattaaag ttatttcttc
     5461 ttctttattt aaatctttaa aaatagaaat atactttaaa ttttcactat aatattcttt
     5521 tatttttatt ctatctttat atatatattt tctcaaaatt atattatttc tataatttga
     5581 tgatttattt attattatct ctccaaacaa tagtgaatcg attttataaa ttaatttatt
     5641 atctataaaa ttataaagat taactttacc ttttaattca ttaattatta atttctcact
     5701 taaatttaaa agatcaatat ggatacaaaa agtcatgccg ctaaatacat atttaataaa
     5761 aatattatta ttaaaactca atatatctga tataactccc aatattttat ttgattttat
     5821 attttttttt agtttaatta tttttatgat aaaataatct ataaattttt ctacaattat
     5881 aaaaatttga ttatatattc caatataata atataattta tctaacaaat tagactcata
     5941 attattattt tcatttttaa gtatgtatat tcgtttaact aaatctatat atttaaaatc
     6001 atattcttta ttagatatta actttttaaa taatttattt ttaaatctca attttgaacc
     6061 tataattaag tacttattaa taggttctaa aaataatatt aattcattat tttcattaat
     6121 aaatatattc gaaatttcca acctttcttt ataatatcga ttaagattat aaagttttat
     6181 ttgtatttta aaatgaaaat ttattttttt tattaataaa atatttgaat ttaatgaaat
     6241 tatatataaa taattttgac cttgtttata aaaaaattct gcattagtta atgaaaattt
     6301 taaattattt tttttactta aaaatactaa tttcatatta gtttcatcta aatatatgta
     6361 ttttttttta tcaaaatata taatatgata ttctatatac tttattaaat ttttaaattt
     6421 atttatcata ttttattatt tccaaatttt ctagcaatat cttattattc tcaaactttc
     6481 ttataccttc atttagtaat tctattgctt tttctcttaa atcattatta taataaactt
     6541 ctgatattaa agaaattata tcaatattat ctgttttttg atagttattt aaattattaa
     6601 tgatatttaa ggcttcctta tattcattat tttctgaaag aatatatata taatcatata
     6661 ttatttcaat atttttatct aaaatataag cttccttgta attaaatatt gcttctttta
     6721 aatcttcatt ctttaatgat ataaatcctt ttaaagaata aatttctggt attgtactat
     6781 ccaaatctaa ggctatttcc aattcattta aagcctcttc tatctgttca ttttttaaaa
     6841 ataatttaga taattcaata tgatattcag caaaatatgg atctaataaa atcaatttct
     6901 tataagtttc tattgcttct tttaaataat ttgctttagt atagcattgc cctaaattaa
     6961 ataataaaac tgttttttgt aataatgttt tatttatatc aaacttttct aactcttcta
     7021 ttaatttttt tactaattca attgcttcat catatttttt atcattaaat aaaaaaaatg
     7081 catatccatt tctgttaaaa attttattaa tctcaattct agtattatca ggctttctaa
     7141 ggttatttaa aatctcatat ccttcattta tatactttaa tcctaaatta taatctcttc
     7201 tataagtttc catatgccta gcttgaagaa ttgataaaga atataaacaa ctcgctttat
     7261 cttcataaga tccataagaa taccattttt ttaaataata ttctgatttt attgtatctt
     7321 ctttcatatt atacgcaata gaaaataatg tatataattt tacagatgtc tctttttttt
     7381 ctatgaaatt taatattgat aaagcagtat aataatctcc aatattaaga taatattctg
     7441 tttgtttaat taaaaattct atgacatttt tatctgcaaa attatttttt agataataat
     7501 ttatttcttt ttcttgatct gtataaatta tattttcatc tttatctgta ttttcaatta
     7561 taatttttat attatttgga aataattctt caaatatatt aaaaaataat tttgttcctt
     7621 catctaattt atcataatta tttattgaaa ttgataaatt cttataatta cgaataatat
     7681 attttattat cttaataatt tctcttttaa ttttattttt tgtataaaat ctaatttgat
     7741 tttgaatttt agctgaggaa gttagagaaa attttaaatt ctcatcatta aattttaaat
     7801 ttaaaatttt acaagctctt ttaaattcta aatttttctc tatttctaac atttttaatt
     7861 tataaataat agtttttaat cctaaaaaag atatcaaaat tttgtcttta acaattaatt
     7921 caaccataac atattctcct tttaaaattt ttattttaaa aaagctgtta aaaataacag
     7981 cctttctcat tttttagaaa gctagacacc catctttata acaatacata acagagaagt
     8041 ttactttctt taattcaatt ttctttttta ttaacttttt cataaaaatc actccttttt
     8101 aatttatatt caaaatatat ctctgttttt ttcatttgtc aataaaagtt ttatttttaa
     8161 cttacagtta cctaattatt atttccaaat ttgataccat tttttatttt ttttattttc
     8221 taacaataat tgatatgttt tattagtttc tgaaatttgc tcaaataatc tttgataatt
     8281 taatttatct tcttttattt cttcttccat tcttgaaata aaattatttt tattttctaa
     8341 ttgtatattt aatattttta tttcttgttc taattcttta atttttttat tttgattttc
     8401 agtttcaaaa tttaataatt taattatatc attttgacta tcaattttgg gggcactttt
     8461 gatactttga gtttcaaaag gtattaatga agtatcaatt tgagtatcaa ttatatataa
     8521 tttaccatct tctcctttta cttctttgac acttccttct ctaacatatt tttttagtgt
     8581 attcctagat tttataccct ttaaagccat atattcttta tatgtaaatt tcataaattt
     8641 ctccttttga ctatcaattt gacaatgtca attgactatc aatgatcatc aaattgacta
     8701 tcaatttcat tatacctcta tttctattaa attccaatat ttttttactg tattcttaga
     8761 aagtcccgtt tctttctgac aacgatacat tgtagcatta ggattatttt ttttatattc
     8821 aataactata ttttcttttg ttccttcacc aataggttta ccatttttat ttctccattc
     8881 tccatttgga aaatctaaat tttgcaatat tcttgctctt aataaatgtt ctttttgttt
     8941 tctaccattt cttttattag gtggaataat aattccagta attttttcaa tatcttttct
     9001 aggaaatgtc gaataatttt ctctaaatgc ctttaaagag tcttcaatat cttctttggt
     9061 aaaatgatta tcttcattca ttgttaaatt ttccataggt gctaataaag aataagaatc
     9121 tttttttaat tcttcataat caatattaca tttaatggca tacatagcta aactcatcaa
     9181 acaaaaatat ctatgacctt ctttaacttc atttccttta attttattta accaccaatc
     9241 gtataaatct cttttaatat tccatttccc ccttttttcg cctttaacta ttcttctttc
     9301 ataccaatct gggtacaatt cttttgcttt ttctaatgat attttactat gtctatatgt
     9361 agatttatta atcatagcaa tttgatccat agtcaatctt tttttctctt cataaataaa
     9421 gttattaaga tattctattg tagcataagg aatatcatta aatttaaaag ccgttacaat
     9481 ttctccaaat ttagttttag ttccaggtaa tctaaaacct tgaaaaattc cttgaacttg
     9541 tttttcagaa atactagatg tatacatatt ccaaatttca acagtaagtt tatacttaaa
     9601 atctttaagt aaaactttaa tattatcaaa taaagcaatt ggcttttcaa ataaataata
     9661 taaatgaact ccattaccac tattaacaat caaatttgca ataggtaatc ttttagttct
     9721 catttgatgt aataaatctt gtaaattaga taaaaaaact ccatcaatat caaaagcaat
     9781 accataacaa tatctagcat tattagaatt tctatttcta cctatataag ttataggaga
     9841 tgtaataaca aagtcttgac cttcaaattc tggtaattct tctaaatctc ttgtaataat
     9901 tttactaaaa cttttctctt tttttatatt aacaataata gaattatact ggccttcaac
     9961 ataattttct ttccctttta attcaaaagg atactcatta tttctcataa aaacaaattc
    10021 ataaaaacca tataaatcaa tacgatccaa atcaaaaata tcattatatt ctaaaaataa
    10081 atttttctca ttaaaattct gaattttatc ttcaatagtt aaatattcaa cattcttatt
    10141 agacataact actccttaat tttatatata attaaaaaat ttttctcata cttaaacgat
    10201 aaatagcttc ataataacca tatggcgtta ttttatcaat acagtttttt gaccctattt
    10261 tattttaaca aatttttatg ctaatagtca ataaatagct tgattttatt ttgtttttag
    10321 agtataatta tgttgtaaat aattataatt attaaaaatt agttgataca ttggcataga
    10381 tagtttggcg actatctatt tttttttatt ttatgttata ataaaatcgc ctctgctttt
    10441 tttctacgag gaaaggagta gaaatgtatc aactaataaa aaaaataata gcatttgtat
    10501 tattaggtat tataataatc gccaatatta tattaccctt aacaatgtta ttttaaaatt
    10561 tttctgcagc cttttgctgc agttttttat ttaaaatgaa ttatgcttct aatttgctaa
    10621 aaattgcccc tctaagctcc aaaatcaaaa aaaaaggttt taatacccct taatataaaa
    10681 aatggctcag aattgaaatt tg
//
