smi_0011 PWY-6599 guanine and guanosine salvage II smi_0011 PWY-6609 adenine and adenosine salvage III smi_0011 PWY-6610 adenine and adenosine salvage IV smi_0011 PWY-6620 guanine and guanosine salvage smi_0022 PWY-7219 adenosine ribonucleotides de novo biosynthesis smi_0030 PWY-241 C4 photosynthetic carbon assimilation cycle, NADP-ME type smi_0030 PWY-6142 gluconeogenesis II (Methanobacterium thermoautotrophicum) smi_0030 PWY-7115 C4 photosynthetic carbon assimilation cycle, NAD-ME type smi_0030 PWY-7117 C4 photosynthetic carbon assimilation cycle, PEPCK type smi_0066 PWY-6123 inosine-5'-phosphate biosynthesis I smi_0066 PWY-6124 inosine-5'-phosphate biosynthesis II smi_0066 PWY-7234 inosine-5'-phosphate biosynthesis III smi_0068 PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I smi_0068 PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II smi_0068 PWY-6277 superpathway of 5-aminoimidazole ribonucleotide biosynthesis smi_0068 PWY-7282 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis (yeast) smi_0069 PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I smi_0069 PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II smi_0069 PWY-6277 superpathway of 5-aminoimidazole ribonucleotide biosynthesis smi_0070 PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I smi_0070 PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate smi_0072 PWY-6123 inosine-5'-phosphate biosynthesis I smi_0072 PWY-6124 inosine-5'-phosphate biosynthesis II smi_0072 PWY-7234 inosine-5'-phosphate biosynthesis III smi_0073 PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I smi_0073 PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II smi_0073 PWY-6277 superpathway of 5-aminoimidazole ribonucleotide biosynthesis smi_0074 PWY-6123 inosine-5'-phosphate biosynthesis I smi_0074 PWY-7234 inosine-5'-phosphate biosynthesis III smi_0076 PWY-6123 inosine-5'-phosphate biosynthesis I smi_0076 PWY-6124 inosine-5'-phosphate biosynthesis II smi_0076 PWY-7219 adenosine ribonucleotides de novo biosynthesis smi_0076 PWY-7234 inosine-5'-phosphate biosynthesis III smi_0079 PWY-6807 xyloglucan degradation II (exoglucanase) smi_0080 PWY-7310 D-glucosaminate degradation smi_0108 PWY-7310 D-glucosaminate degradation smi_0109 PWY-7310 D-glucosaminate degradation smi_0111 PWY-6891 thiazole biosynthesis II (Bacillus) smi_0111 PWY-6892 thiazole biosynthesis I (E. coli) smi_0111 PWY-7560 methylerythritol phosphate pathway II smi_0113 PWY-5101 L-isoleucine biosynthesis II smi_0113 PWY-5103 L-isoleucine biosynthesis III smi_0113 PWY-5104 L-isoleucine biosynthesis IV smi_0113 PWY-7111 pyruvate fermentation to isobutanol (engineered) smi_0134 PWY-5941 glycogen degradation II (eukaryotic) smi_0134 PWY-6724 starch degradation II smi_0134 PWY-6737 starch degradation V smi_0134 PWY-7238 sucrose biosynthesis II smi_0135 PWY-5941 glycogen degradation II (eukaryotic) smi_0135 PWY-622 starch biosynthesis smi_0135 PWY-6731 starch degradation III smi_0135 PWY-6737 starch degradation V smi_0135 PWY-7238 sucrose biosynthesis II smi_0143 PWY-2941 L-lysine biosynthesis II smi_0144 PWY-2941 L-lysine biosynthesis II smi_0147 PWY-3801 sucrose degradation II (sucrose synthase) smi_0147 PWY-6527 stachyose degradation smi_0147 PWY-6981 chitin biosynthesis smi_0147 PWY-7238 sucrose biosynthesis II smi_0147 PWY-7343 UDP-glucose biosynthesis smi_0148 PWY-5667 CDP-diacylglycerol biosynthesis I smi_0148 PWY-5981 CDP-diacylglycerol biosynthesis III smi_0157 PWY-3801 sucrose degradation II (sucrose synthase) smi_0157 PWY-5054 sorbitol biosynthesis I smi_0157 PWY-5384 sucrose degradation IV (sucrose phosphorylase) smi_0157 PWY-5514 UDP-N-acetyl-D-galactosamine biosynthesis II smi_0157 PWY-5659 GDP-mannose biosynthesis smi_0157 PWY-6142 gluconeogenesis II (Methanobacterium thermoautotrophicum) smi_0157 PWY-621 sucrose degradation III (sucrose invertase) smi_0157 PWY-622 starch biosynthesis smi_0157 PWY-6531 mannitol cycle smi_0157 PWY-6981 chitin biosynthesis smi_0157 PWY-7238 sucrose biosynthesis II smi_0157 PWY-7347 sucrose biosynthesis III smi_0157 PWY-7385 1,3-propanediol biosynthesis (engineered) smi_0158 PWY-5188 tetrapyrrole biosynthesis I (from glutamate) smi_0199 PWY-6700 queuosine biosynthesis smi_0202 PWY-6906 chitin derivatives degradation smi_0202 PWY-7077 N-acetyl-D-galactosamine degradation smi_0202 PWY-7395 D-galactosamine and N-acetyl-D-galactosamine degradation smi_0214 PWY-5482 pyruvate fermentation to acetate II smi_0214 PWY-5485 pyruvate fermentation to acetate IV smi_0214 PWY-5497 purine nucleobases degradation II (anaerobic) smi_0220 PWY-7310 D-glucosaminate degradation smi_0222 PWY-5686 UMP biosynthesis smi_0223 PWY-6961 L-ascorbate degradation II (bacterial, aerobic) smi_0225 PWY-7310 D-glucosaminate degradation smi_0227 PWY-1861 formaldehyde assimilation II (RuMP Cycle) smi_0227 PWY-5723 Rubisco shunt smi_0227 PWY-6891 thiazole biosynthesis II (Bacillus) smi_0227 PWY-6892 thiazole biosynthesis I (E. coli) smi_0227 PWY-6901 superpathway of glucose and xylose degradation smi_0227 PWY-7560 methylerythritol phosphate pathway II smi_0231 PWY-3162 L-tryptophan degradation V (side chain pathway) smi_0231 PWY-5057 L-valine degradation II smi_0231 PWY-5076 L-leucine degradation III smi_0231 PWY-5078 L-isoleucine degradation II smi_0231 PWY-5079 L-phenylalanine degradation III smi_0231 PWY-5082 L-methionine degradation III smi_0231 PWY-5162 2-oxopentenoate degradation smi_0231 PWY-5436 L-threonine degradation IV smi_0231 PWY-5480 pyruvate fermentation to ethanol I smi_0231 PWY-5486 pyruvate fermentation to ethanol II smi_0231 PWY-5751 phenylethanol biosynthesis smi_0231 PWY-6028 acetoin degradation smi_0231 PWY-6313 serotonin degradation smi_0231 PWY-6333 acetaldehyde biosynthesis I smi_0231 PWY-6342 noradrenaline and adrenaline degradation smi_0231 PWY-6587 pyruvate fermentation to ethanol III smi_0231 PWY-6802 salidroside biosynthesis smi_0231 PWY-6871 3-methylbutanol biosynthesis smi_0231 PWY-7013 L-1,2-propanediol degradation smi_0231 PWY-7085 triethylamine degradation smi_0231 PWY-7111 pyruvate fermentation to isobutanol (engineered) smi_0231 PWY-7118 chitin degradation to ethanol smi_0231 PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation smi_0231 PWY-7396 butanol and isobutanol biosynthesis (engineered) smi_0231 PWY-7557 dehydrodiconiferyl alcohol degradation smi_0232 PWY-1042 glycolysis IV (plant cytosol) smi_0232 PWY-5484 glycolysis II (from fructose 6-phosphate) smi_0232 PWY-6901 superpathway of glucose and xylose degradation smi_0232 PWY-7003 glycerol degradation to butanol smi_0274 PWY-7310 D-glucosaminate degradation smi_0279 PWY-6614 tetrahydrofolate biosynthesis smi_0280 PWY-2161 folate polyglutamylation smi_0281 PWY-5663 tetrahydrobiopterin biosynthesis I smi_0281 PWY-5664 tetrahydrobiopterin biosynthesis II smi_0281 PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I smi_0281 PWY-6703 preQ0 biosynthesis smi_0281 PWY-6983 tetrahydrobiopterin biosynthesis III smi_0281 PWY-7442 drosopterin and aurodrosopterin biosynthesis smi_0282 PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I smi_0282 PWY-6148 tetrahydromethanopterin biosynthesis smi_0282 PWY-6797 6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (archaea) smi_0282 PWY-7539 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia) smi_0297 PWY-1861 formaldehyde assimilation II (RuMP Cycle) smi_0297 PWY-5723 Rubisco shunt smi_0298 PWY-6898 thiamin salvage III smi_0298 PWY-6907 thiamin diphosphate biosynthesis III (Staphylococcus) smi_0298 PWY-6908 thiamin diphosphate biosynthesis IV (eukaryotes) smi_0303 PWY-2941 L-lysine biosynthesis II smi_0303 PWY-2942 L-lysine biosynthesis III smi_0303 PWY-5097 L-lysine biosynthesis VI smi_0317 PWY-6386 UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) smi_0317 PWY-6387 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) smi_0332 PWY-6386 UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) smi_0332 PWY-6387 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) smi_0333 PWY-7206 pyrimidine deoxyribonucleotides dephosphorylation smi_0341 PWY-3821 galactose degradation III smi_0341 PWY-6317 galactose degradation I (Leloir pathway) smi_0341 PWY-6397 mycolyl-arabinogalactan-peptidoglycan complex biosynthesis smi_0341 PWY-6527 stachyose degradation smi_0341 PWY-7328 superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis smi_0341 PWY-7344 UDP-D-galactose biosynthesis smi_0346 PWY-1042 glycolysis IV (plant cytosol) smi_0346 PWY-5484 glycolysis II (from fructose 6-phosphate) smi_0346 PWY-6886 1-butanol autotrophic biosynthesis smi_0346 PWY-6901 superpathway of glucose and xylose degradation smi_0346 PWY-7003 glycerol degradation to butanol smi_0349 PWY-381 nitrate reduction II (assimilatory) smi_0349 PWY-5675 nitrate reduction V (assimilatory) smi_0349 PWY-6549 L-glutamine biosynthesis III smi_0349 PWY-6963 ammonia assimilation cycle I smi_0349 PWY-6964 ammonia assimilation cycle II smi_0401 PWY-7176 UTP and CTP de novo biosynthesis smi_0401 PWY-7177 UTP and CTP dephosphorylation II smi_0401 PWY-7185 UTP and CTP dephosphorylation I smi_0511 PWY-6987 lipoate biosynthesis and incorporation III (Bacillus) smi_0511 PWY-7381 lipoate biosynthesis and incorporation (glycine cleavage system, yeast) smi_0520 PWY-3821 galactose degradation III smi_0520 PWY-6317 galactose degradation I (Leloir pathway) smi_0520 PWY-6527 stachyose degradation smi_0521 PWY-6317 galactose degradation I (Leloir pathway) smi_0521 PWY-6527 stachyose degradation smi_0541 PWY-5958 acridone alkaloid biosynthesis smi_0541 PWY-6660 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis smi_0541 PWY-6661 4-hydroxy-2(1H)-quinolone biosynthesis smi_0542 PWY-5958 acridone alkaloid biosynthesis smi_0542 PWY-6660 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis smi_0542 PWY-6661 4-hydroxy-2(1H)-quinolone biosynthesis smi_0567 PWY-6389 (S)-acetoin biosynthesis smi_0569 PWY-6700 queuosine biosynthesis smi_0570 PWY-6703 preQ0 biosynthesis smi_0572 PWY-6703 preQ0 biosynthesis smi_0590 PWY-1269 CMP-3-deoxy-D-manno-octulosonate biosynthesis I smi_0590 PWY-5111 CMP-3-deoxy-D-manno-octulosonate biosynthesis II (from D-arabinose 5-phosphate) smi_0590 PWY-6164 3-dehydroquinate biosynthesis I smi_0591 PWY-1269 CMP-3-deoxy-D-manno-octulosonate biosynthesis I smi_0591 PWY-5111 CMP-3-deoxy-D-manno-octulosonate biosynthesis II (from D-arabinose 5-phosphate) smi_0591 PWY-6164 3-dehydroquinate biosynthesis I smi_0592 PWY-6012 acyl carrier protein metabolism I smi_0592 PWY-6012-1 acyl carrier protein metabolism II (mammalian) smi_0593 PWY-7383 anaerobic energy metabolism (invertebrates, cytosol) smi_0615 PWY-6386 UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) smi_0615 PWY-6387 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) smi_0616 PWY-6386 UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) smi_0616 PWY-6387 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) smi_0622 PWY-7383 anaerobic energy metabolism (invertebrates, cytosol) smi_0629 PWY-1622 formaldehyde assimilation I (serine pathway) smi_0629 PWY-5484 glycolysis II (from fructose 6-phosphate) smi_0665 PWY-5663 tetrahydrobiopterin biosynthesis I smi_0665 PWY-5664 tetrahydrobiopterin biosynthesis II smi_0665 PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I smi_0665 PWY-6703 preQ0 biosynthesis smi_0665 PWY-6983 tetrahydrobiopterin biosynthesis III smi_0665 PWY-7442 drosopterin and aurodrosopterin biosynthesis smi_0668 PWY-3821 galactose degradation III smi_0668 PWY-6317 galactose degradation I (Leloir pathway) smi_0668 PWY-6397 mycolyl-arabinogalactan-peptidoglycan complex biosynthesis smi_0668 PWY-6527 stachyose degradation smi_0668 PWY-7328 superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis smi_0668 PWY-7344 UDP-D-galactose biosynthesis smi_0672 PWY-7205 CMP phosphorylation smi_0695 PWY-1042 glycolysis IV (plant cytosol) smi_0695 PWY-1861 formaldehyde assimilation II (RuMP Cycle) smi_0695 PWY-5484 glycolysis II (from fructose 6-phosphate) smi_0695 PWY-6142 gluconeogenesis II (Methanobacterium thermoautotrophicum) smi_0695 PWY-7385 1,3-propanediol biosynthesis (engineered) smi_0713 PWY-6700 queuosine biosynthesis smi_0714 PWY-5514 UDP-N-acetyl-D-galactosamine biosynthesis II smi_0714 PWY-6855 chitin degradation I (archaea) smi_0714 PWY-6906 chitin derivatives degradation smi_0740 PWY-5939 (R)-acetoin biosynthesis II smi_0742 PWY-6386 UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) smi_0742 PWY-6387 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) smi_0750 PWY-842 starch degradation I smi_0755 PWY-6163 chorismate biosynthesis from 3-dehydroquinate smi_0755 PWY-6416 quinate degradation II smi_0755 PWY-6707 gallate biosynthesis smi_0756 PWY-6163 chorismate biosynthesis from 3-dehydroquinate smi_0757 PWY-6164 3-dehydroquinate biosynthesis I smi_0758 PWY-6163 chorismate biosynthesis from 3-dehydroquinate smi_0759 PWY-7303 3-dimethylallyl-4-hydroxybenzoate biosynthesis smi_0763 PWY-6163 chorismate biosynthesis from 3-dehydroquinate smi_0764 PWY-6163 chorismate biosynthesis from 3-dehydroquinate smi_0765 PWY-7432 L-phenylalanine biosynthesis III (cytosolic, plants) smi_0774 PWY-702 L-methionine biosynthesis II smi_0805 PWY-7219 adenosine ribonucleotides de novo biosynthesis smi_0806 PWY-7219 adenosine ribonucleotides de novo biosynthesis smi_0817 PWY-6854 ethylene biosynthesis III (microbes) smi_0830 PWY-6829 tRNA methylation (yeast) smi_0830 PWY-7285 methylwyosine biosynthesis smi_0830 PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis smi_0838 PWY-4081 glutathione redox reactions I smi_0869 PWY-1722 formate reduction to 5,10-methylenetetrahydrofolate smi_0869 PWY-2201 folate transformations I smi_0869 PWY-3841 folate transformations II smi_0869 PWY-5030 L-histidine degradation III smi_0869 PWY-5497 purine nucleobases degradation II (anaerobic) smi_0869 PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate smi_0873 PWY-1861 formaldehyde assimilation II (RuMP Cycle) smi_0873 PWY-5723 Rubisco shunt smi_0874 PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation smi_0876 PWY-4202 arsenate detoxification I (glutaredoxin) smi_0876 PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation smi_0876 PWY-6608 guanosine nucleotides degradation III smi_0876 PWY-6609 adenine and adenosine salvage III smi_0876 PWY-6611 adenine and adenosine salvage V smi_0876 PWY-6620 guanine and guanosine salvage smi_0876 PWY-6627 salinosporamide A biosynthesis smi_0876 PWY-6644 fluoroacetate and fluorothreonine biosynthesis smi_0876 PWY-7179 purine deoxyribonucleosides degradation I smi_0876 PWY-7179-1 purine deoxyribonucleosides degradation smi_0879 PWY-4202 arsenate detoxification I (glutaredoxin) smi_0879 PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation smi_0879 PWY-6608 guanosine nucleotides degradation III smi_0879 PWY-6609 adenine and adenosine salvage III smi_0879 PWY-6611 adenine and adenosine salvage V smi_0879 PWY-6620 guanine and guanosine salvage smi_0879 PWY-6627 salinosporamide A biosynthesis smi_0879 PWY-6644 fluoroacetate and fluorothreonine biosynthesis smi_0879 PWY-7179 purine deoxyribonucleosides degradation I smi_0879 PWY-7179-1 purine deoxyribonucleosides degradation smi_0883 PWY-3961 phosphopantothenate biosynthesis II smi_0889 PWY-7181 pyrimidine deoxyribonucleosides degradation smi_0890 PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation smi_0891 PWY-6556 pyrimidine ribonucleosides salvage II smi_0891 PWY-7181 pyrimidine deoxyribonucleosides degradation smi_0891 PWY-7193 pyrimidine ribonucleosides salvage I smi_0891 PWY-7199 pyrimidine deoxyribonucleosides salvage smi_0906 PWY-5057 L-valine degradation II smi_0906 PWY-5076 L-leucine degradation III smi_0906 PWY-5078 L-isoleucine degradation II smi_0906 PWY-5101 L-isoleucine biosynthesis II smi_0906 PWY-5103 L-isoleucine biosynthesis III smi_0906 PWY-5104 L-isoleucine biosynthesis IV smi_0906 PWY-5108 L-isoleucine biosynthesis V smi_0917 PWY-6823 molybdenum cofactor biosynthesis smi_0917 PWY-6891 thiazole biosynthesis II (Bacillus) smi_0917 PWY-6892 thiazole biosynthesis I (E. coli) smi_0917 PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis smi_0920 PWY-5265 peptidoglycan biosynthesis II (staphylococci) smi_0920 PWY-6471 peptidoglycan biosynthesis IV (Enterococcus faecium) smi_0937 PWY-3341 L-proline biosynthesis III smi_0937 PWY-4981 L-proline biosynthesis II (from arginine) smi_0937 PWY-6344 L-ornithine degradation II (Stickland reaction) smi_0938 PWY-6545 pyrimidine deoxyribonucleotides de novo biosynthesis III smi_0938 PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I smi_0938 PWY-7187 pyrimidine deoxyribonucleotides de novo biosynthesis II smi_0938 PWY-7197 pyrimidine deoxyribonucleotide phosphorylation smi_0938 PWY-7198 pyrimidine deoxyribonucleotides de novo biosynthesis IV smi_0938 PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP smi_0962 PWY-5386 methylglyoxal degradation I smi_0969 PWY-7039 phosphatidate metabolism, as a signaling molecule smi_0985 PWY-1622 formaldehyde assimilation I (serine pathway) smi_0985 PWY-241 C4 photosynthetic carbon assimilation cycle, NADP-ME type smi_0985 PWY-5913 TCA cycle VI (obligate autotrophs) smi_0985 PWY-6142 gluconeogenesis II (Methanobacterium thermoautotrophicum) smi_0985 PWY-6146 Methanobacterium thermoautotrophicum biosynthetic metabolism smi_0985 PWY-6549 L-glutamine biosynthesis III smi_0985 PWY-7115 C4 photosynthetic carbon assimilation cycle, NAD-ME type smi_0985 PWY-7117 C4 photosynthetic carbon assimilation cycle, PEPCK type smi_0985 PWY-7124 ethylene biosynthesis V (engineered) smi_1004 PWY-1042 glycolysis IV (plant cytosol) smi_1004 PWY-1861 formaldehyde assimilation II (RuMP Cycle) smi_1004 PWY-5484 glycolysis II (from fructose 6-phosphate) smi_1004 PWY-7385 1,3-propanediol biosynthesis (engineered) smi_1005 PWY-1042 glycolysis IV (plant cytosol) smi_1005 PWY-2221 Entner-Doudoroff pathway III (semi-phosphorylative) smi_1005 PWY-5484 glycolysis II (from fructose 6-phosphate) smi_1005 PWY-5723 Rubisco shunt smi_1005 PWY-6142 gluconeogenesis II (Methanobacterium thermoautotrophicum) smi_1005 PWY-6886 1-butanol autotrophic biosynthesis smi_1005 PWY-6901 superpathway of glucose and xylose degradation smi_1005 PWY-7003 glycerol degradation to butanol smi_1005 PWY-7218 photosynthetic 3-hydroxybutanoate biosynthesis (engineered) smi_1005 PWY-7383 anaerobic energy metabolism (invertebrates, cytosol) smi_1006 PWY-5481 pyruvate fermentation to lactate smi_1006 PWY-6901 superpathway of glucose and xylose degradation smi_1010 PWY-5344 L-homocysteine biosynthesis smi_1010 PWY-7174 S-methyl-5-thio-α-D-ribose 1-phosphate degradation II smi_1013 PWY-7193 pyrimidine ribonucleosides salvage I smi_1023 PWY-7310 D-glucosaminate degradation smi_1028 PWY-7077 N-acetyl-D-galactosamine degradation smi_1028 PWY-7395 D-galactosamine and N-acetyl-D-galactosamine degradation smi_1029 PWY-7077 N-acetyl-D-galactosamine degradation smi_1029 PWY-7395 D-galactosamine and N-acetyl-D-galactosamine degradation smi_1038 PWY-7310 D-glucosaminate degradation smi_1042 PWY-6545 pyrimidine deoxyribonucleotides de novo biosynthesis III smi_1042 PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I smi_1042 PWY-7198 pyrimidine deoxyribonucleotides de novo biosynthesis IV smi_1042 PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP smi_1042 PWY-7220 adenosine deoxyribonucleotides de novo biosynthesis II smi_1042 PWY-7222 guanosine deoxyribonucleotides de novo biosynthesis II smi_1042 PWY-7226 guanosine deoxyribonucleotides de novo biosynthesis I smi_1042 PWY-7227 adenosine deoxyribonucleotides de novo biosynthesis smi_1043 PWY-6545 pyrimidine deoxyribonucleotides de novo biosynthesis III smi_1043 PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I smi_1043 PWY-7198 pyrimidine deoxyribonucleotides de novo biosynthesis IV smi_1043 PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP smi_1043 PWY-7220 adenosine deoxyribonucleotides de novo biosynthesis II smi_1043 PWY-7222 guanosine deoxyribonucleotides de novo biosynthesis II smi_1043 PWY-7226 guanosine deoxyribonucleotides de novo biosynthesis I smi_1043 PWY-7227 adenosine deoxyribonucleotides de novo biosynthesis smi_1056 PWY-6502 oxidized GTP and dGTP detoxification smi_1057 PWY-5686 UMP biosynthesis smi_1105 PWY-5083 NAD/NADH phosphorylation and dephosphorylation smi_1105 PWY-7268 NAD/NADP-NADH/NADPH cytosolic interconversion (yeast) smi_1105 PWY-7269 NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast) smi_1123 PWY-1622 formaldehyde assimilation I (serine pathway) smi_1123 PWY-181 photorespiration smi_1123 PWY-2161 folate polyglutamylation smi_1123 PWY-2201 folate transformations I smi_1123 PWY-3661 glycine betaine degradation I smi_1123 PWY-3661-1 glycine betaine degradation II (mammalian) smi_1123 PWY-3841 folate transformations II smi_1123 PWY-5497 purine nucleobases degradation II (anaerobic) smi_1128 PWY-0 putrescine degradation III smi_1128 PWY-6117 spermine and spermidine degradation I smi_1129 PWY-7199 pyrimidine deoxyribonucleosides salvage smi_1132 PWY-2941 L-lysine biosynthesis II smi_1132 PWY-2942 L-lysine biosynthesis III smi_1132 PWY-5097 L-lysine biosynthesis VI smi_1133 PWY-2941 L-lysine biosynthesis II smi_1133 PWY-2942 L-lysine biosynthesis III smi_1133 PWY-5097 L-lysine biosynthesis VI smi_1133 PWY-5154 L-arginine biosynthesis III (via N-acetyl-L-citrulline) smi_1133 PWY-6559 spermidine biosynthesis II smi_1133 PWY-6562 norspermidine biosynthesis smi_1133 PWY-7153 grixazone biosynthesis smi_1133 PWY-7400 L-arginine biosynthesis IV (archaebacteria) smi_1153 PWY-5523 5,6-dimethylbenzimidazole biosynthesis smi_1153 PWY-6167 flavin biosynthesis II (archaea) smi_1153 PWY-6168 flavin biosynthesis III (fungi) smi_1155 PWY-1281 sulfoacetaldehyde degradation I smi_1155 PWY-5482 pyruvate fermentation to acetate II smi_1155 PWY-5485 pyruvate fermentation to acetate IV smi_1155 PWY-5497 purine nucleobases degradation II (anaerobic) smi_1155 PWY-6637 sulfolactate degradation II smi_1157 PWY-6386 UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) smi_1157 PWY-6387 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) smi_1159 PWY-1042 glycolysis IV (plant cytosol) smi_1159 PWY-1622 formaldehyde assimilation I (serine pathway) smi_1159 PWY-2221 Entner-Doudoroff pathway III (semi-phosphorylative) smi_1159 PWY-5484 glycolysis II (from fructose 6-phosphate) smi_1159 PWY-5723 Rubisco shunt smi_1159 PWY-6142 gluconeogenesis II (Methanobacterium thermoautotrophicum) smi_1159 PWY-6886 1-butanol autotrophic biosynthesis smi_1159 PWY-6901 superpathway of glucose and xylose degradation smi_1159 PWY-7003 glycerol degradation to butanol smi_1159 PWY-7124 ethylene biosynthesis V (engineered) smi_1159 PWY-7218 photosynthetic 3-hydroxybutanoate biosynthesis (engineered) smi_1163 PWY-622 starch biosynthesis smi_1165 PWY-622 starch biosynthesis smi_1166 PWY-5067 glycogen biosynthesis II (from UDP-D-Glucose) smi_1166 PWY-622 starch biosynthesis smi_1168 PWY-842 starch degradation I smi_1173 PWY-6749 CMP-legionaminate biosynthesis I smi_1179 PWY-1281 sulfoacetaldehyde degradation I smi_1179 PWY-5482 pyruvate fermentation to acetate II smi_1179 PWY-5485 pyruvate fermentation to acetate IV smi_1179 PWY-5497 purine nucleobases degradation II (anaerobic) smi_1179 PWY-6637 sulfolactate degradation II smi_1181 PWY-5083 NAD/NADH phosphorylation and dephosphorylation smi_1181 PWY-7268 NAD/NADP-NADH/NADPH cytosolic interconversion (yeast) smi_1181 PWY-7269 NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast) smi_1185 PWY-6823 molybdenum cofactor biosynthesis smi_1185 PWY-6891 thiazole biosynthesis II (Bacillus) smi_1185 PWY-6892 thiazole biosynthesis I (E. coli) smi_1185 PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis smi_1192 PWY-1722 formate reduction to 5,10-methylenetetrahydrofolate smi_1192 PWY-2161 folate polyglutamylation smi_1192 PWY-2201 folate transformations I smi_1192 PWY-3841 folate transformations II smi_1205 PWY-7268 NAD/NADP-NADH/NADPH cytosolic interconversion (yeast) smi_1217 PWY-7396 butanol and isobutanol biosynthesis (engineered) smi_1218 PWY-6871 3-methylbutanol biosynthesis smi_1228 PWY-7560 methylerythritol phosphate pathway II smi_1233 PWY-5154 L-arginine biosynthesis III (via N-acetyl-L-citrulline) smi_1233 PWY-5686 UMP biosynthesis smi_1233 PWY-7400 L-arginine biosynthesis IV (archaebacteria) smi_1234 PWY-5154 L-arginine biosynthesis III (via N-acetyl-L-citrulline) smi_1234 PWY-5686 UMP biosynthesis smi_1234 PWY-7400 L-arginine biosynthesis IV (archaebacteria) smi_1235 PWY-5686 UMP biosynthesis smi_1236 PWY-7183 pyrimidine nucleobases salvage I smi_1268 PWY-3461 L-tyrosine biosynthesis II smi_1268 PWY-3462 L-phenylalanine biosynthesis II smi_1268 PWY-6120 L-tyrosine biosynthesis III smi_1268 PWY-6627 salinosporamide A biosynthesis smi_1288 PWY-6151 S-adenosyl-L-methionine cycle I smi_1288 PWY-6153 autoinducer AI-2 biosynthesis I smi_1288 PWY-6154 autoinducer AI-2 biosynthesis II (Vibrio) smi_1291 PWY-5514 UDP-N-acetyl-D-galactosamine biosynthesis II smi_1309 PWY-7219 adenosine ribonucleotides de novo biosynthesis smi_1311 PWY-7219 adenosine ribonucleotides de novo biosynthesis smi_1342 PWY-7221 guanosine ribonucleotides de novo biosynthesis smi_1354 PWY-6823 molybdenum cofactor biosynthesis smi_1354 PWY-6891 thiazole biosynthesis II (Bacillus) smi_1354 PWY-6892 thiazole biosynthesis I (E. coli) smi_1354 PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis smi_1357 PWY-7310 D-glucosaminate degradation smi_1358 PWY-7077 N-acetyl-D-galactosamine degradation smi_1358 PWY-7395 D-galactosamine and N-acetyl-D-galactosamine degradation smi_1400 PWY-5041 S-adenosyl-L-methionine cycle II smi_1400 PWY-5912 2'-deoxymugineic acid phytosiderophore biosynthesis smi_1404 PWY-7310 D-glucosaminate degradation smi_1418 PWY-7183 pyrimidine nucleobases salvage I smi_1420 PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP smi_1427 PWY-3861 mannitol degradation II smi_1427 PWY-3881 mannitol biosynthesis smi_1427 PWY-5659 GDP-mannose biosynthesis smi_1427 PWY-7456 mannan degradation smi_1427 PWY-882 L-ascorbate biosynthesis I (L-galactose pathway) smi_1445 PWY-5686 UMP biosynthesis smi_1446 PWY-5686 UMP biosynthesis smi_1448 PWY-5265 peptidoglycan biosynthesis II (staphylococci) smi_1448 PWY-6385 peptidoglycan biosynthesis III (mycobacteria) smi_1448 PWY-6470 peptidoglycan biosynthesis V (β-lactam resistance) smi_1448 PWY-6471 peptidoglycan biosynthesis IV (Enterococcus faecium) smi_1449 PWY-6386 UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) smi_1449 PWY-6387 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) smi_1475 PWY-2781 cis-zeatin biosynthesis smi_1477 PWY-3841 folate transformations II smi_1477 PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I smi_1477 PWY-7187 pyrimidine deoxyribonucleotides de novo biosynthesis II smi_1477 PWY-7198 pyrimidine deoxyribonucleotides de novo biosynthesis IV smi_1477 PWY-7199 pyrimidine deoxyribonucleosides salvage smi_1477 PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP smi_1478 PWY-2723 trehalose degradation V smi_1478 PWY-5514 UDP-N-acetyl-D-galactosamine biosynthesis II smi_1478 PWY-5661 GDP-glucose biosynthesis smi_1478 PWY-7238 sucrose biosynthesis II smi_1478 PWY-7385 1,3-propanediol biosynthesis (engineered) smi_1481 PWY-5958 acridone alkaloid biosynthesis smi_1481 PWY-6543 4-aminobenzoate biosynthesis smi_1481 PWY-6660 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis smi_1481 PWY-6661 4-hydroxy-2(1H)-quinolone biosynthesis smi_1481 PWY-6722 candicidin biosynthesis smi_1492 PWY-5381 pyridine nucleotide cycling (plants) smi_1502 PWY-6386 UDP-N-acetylmuramoyl-pentapeptide biosynthesis II (lysine-containing) smi_1502 PWY-6387 UDP-N-acetylmuramoyl-pentapeptide biosynthesis I (meso-diaminopimelate containing) smi_1507 PWY-6936 seleno-amino acid biosynthesis smi_1534 PWY-6807 xyloglucan degradation II (exoglucanase) smi_1537 PWY-6902 chitin degradation II smi_1537 PWY-7437 protein O-[N-acetyl]-glucosylation smi_1547 PWY-2941 L-lysine biosynthesis II smi_1547 PWY-2942 L-lysine biosynthesis III smi_1547 PWY-5097 L-lysine biosynthesis VI smi_1550 PWY-6749 CMP-legionaminate biosynthesis I smi_1553 PWY-101 photosynthesis light reactions smi_1553 PWY-7230 ubiquinol-6 biosynthesis from 4-aminobenzoate (eukaryotic) smi_1561 PWY-3841 folate transformations II smi_1561 PWY-6614 tetrahydrofolate biosynthesis smi_1564 PWY-1042 glycolysis IV (plant cytosol) smi_1564 PWY-5484 glycolysis II (from fructose 6-phosphate) smi_1564 PWY-6142 gluconeogenesis II (Methanobacterium thermoautotrophicum) smi_1564 PWY-7003 glycerol degradation to butanol smi_1567 PWY-6605 adenine and adenosine salvage II smi_1567 PWY-6610 adenine and adenosine salvage IV smi_1597 PWY-6936 seleno-amino acid biosynthesis smi_1597 PWY-7274 D-cycloserine biosynthesis smi_1599 PWY-2201 folate transformations I smi_1599 PWY-3841 folate transformations II smi_1600 PWY-5041 S-adenosyl-L-methionine cycle II smi_1600 PWY-6151 S-adenosyl-L-methionine cycle I smi_1600 PWY-6936 seleno-amino acid biosynthesis smi_1600 PWY-702 L-methionine biosynthesis II smi_1615 PWY-7310 D-glucosaminate degradation smi_1616 PWY-621 sucrose degradation III (sucrose invertase) smi_1618 PWY-6174 mevalonate pathway II (archaea) smi_1618 PWY-7391 isoprene biosynthesis II (engineered) smi_1618 PWY-7524 mevalonate pathway III (archaea) smi_1618 PWY-922 mevalonate pathway I smi_1619 PWY-6174 mevalonate pathway II (archaea) smi_1619 PWY-7391 isoprene biosynthesis II (engineered) smi_1619 PWY-7524 mevalonate pathway III (archaea) smi_1619 PWY-922 mevalonate pathway I smi_1628 PWY-7221 guanosine ribonucleotides de novo biosynthesis smi_1637 PWY-5381 pyridine nucleotide cycling (plants) smi_1637 PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde smi_1666 PWY-5921 glutaminyl-tRNAgln biosynthesis via transamidation smi_1674 PWY-4381 fatty acid biosynthesis initiation I smi_1674 PWY-5743 3-hydroxypropanoate cycle smi_1674 PWY-5744 glyoxylate assimilation smi_1674 PWY-5789 3-hydroxypropanoate/4-hydroxybutanate cycle smi_1674 PWY-6679 jadomycin biosynthesis smi_1674 PWY-7388 octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) smi_1675 PWY-4381 fatty acid biosynthesis initiation I smi_1675 PWY-5743 3-hydroxypropanoate cycle smi_1675 PWY-5744 glyoxylate assimilation smi_1675 PWY-5789 3-hydroxypropanoate/4-hydroxybutanate cycle smi_1675 PWY-6679 jadomycin biosynthesis smi_1675 PWY-7388 octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) smi_1677 PWY-5971 palmitate biosynthesis II (bacteria and plants) smi_1677 PWY-5973 cis-vaccenate biosynthesis smi_1677 PWY-5989 stearate biosynthesis II (bacteria and plants) smi_1677 PWY-5994 palmitate biosynthesis I (animals and fungi) smi_1677 PWY-6113 superpathway of mycolate biosynthesis smi_1677 PWY-6282 palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) smi_1677 PWY-6519 8-amino-7-oxononanoate biosynthesis I smi_1677 PWY-7388 octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) smi_1677 PWYG-321 mycolate biosynthesis smi_1680 PWY-5367 petroselinate biosynthesis smi_1680 PWY-5971 palmitate biosynthesis II (bacteria and plants) smi_1680 PWY-5973 cis-vaccenate biosynthesis smi_1680 PWY-5989 stearate biosynthesis II (bacteria and plants) smi_1680 PWY-5994 palmitate biosynthesis I (animals and fungi) smi_1680 PWY-6113 superpathway of mycolate biosynthesis smi_1680 PWY-6282 palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) smi_1680 PWY-6519 8-amino-7-oxononanoate biosynthesis I smi_1680 PWY-6951 smi_1680|fabG|YP_003446782.1|GeneID:8798908 smi_1680 PWY-7053 docosahexaenoate biosynthesis I (lower eukaryotes) smi_1680 PWY-7388 octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) smi_1680 PWYG-321 mycolate biosynthesis smi_1681 PWY-4381 fatty acid biosynthesis initiation I smi_1681 PWY-6799 fatty acid biosynthesis (plant mitochondria) smi_1681 PWY-7388 octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) smi_1682 PWY-723 alkylnitronates degradation smi_1684 PWY-4381 fatty acid biosynthesis initiation I smi_1687 PWY-2941 L-lysine biosynthesis II smi_1687 PWY-2942 L-lysine biosynthesis III smi_1687 PWY-5097 L-lysine biosynthesis VI smi_1687 PWY-6559 spermidine biosynthesis II smi_1687 PWY-6562 norspermidine biosynthesis smi_1687 PWY-7153 grixazone biosynthesis smi_1689 PWY-6281 L-selenocysteine biosynthesis II (archaea and eukaryotes) smi_1744 PWY-5123 trans, trans-farnesyl diphosphate biosynthesis smi_1744 PWY-6174 mevalonate pathway II (archaea) smi_1744 PWY-6383 mono-trans, poly-cis decaprenyl phosphate biosynthesis smi_1744 PWY-6859 all-trans-farnesol biosynthesis smi_1744 PWY-7102 bisabolene biosynthesis smi_1744 PWY-7391 isoprene biosynthesis II (engineered) smi_1744 PWY-7524 mevalonate pathway III (archaea) smi_1744 PWY-7560 methylerythritol phosphate pathway II smi_1744 PWY-922 mevalonate pathway I smi_1745 PWY-7391 isoprene biosynthesis II (engineered) smi_1745 PWY-922 mevalonate pathway I smi_1746 PWY-7391 isoprene biosynthesis II (engineered) smi_1746 PWY-922 mevalonate pathway I smi_1747 PWY-3821 galactose degradation III smi_1747 PWY-6174 mevalonate pathway II (archaea) smi_1747 PWY-6317 galactose degradation I (Leloir pathway) smi_1747 PWY-6527 stachyose degradation smi_1747 PWY-7391 isoprene biosynthesis II (engineered) smi_1747 PWY-922 mevalonate pathway I smi_1759 PWY-6397 mycolyl-arabinogalactan-peptidoglycan complex biosynthesis smi_1759 PWY-7328 superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis smi_1763 PWY-6151 S-adenosyl-L-methionine cycle I smi_1763 PWY-6153 autoinducer AI-2 biosynthesis I smi_1763 PWY-6154 autoinducer AI-2 biosynthesis II (Vibrio) smi_1766 PWY-5265 peptidoglycan biosynthesis II (staphylococci) smi_1766 PWY-6470 peptidoglycan biosynthesis V (β-lactam resistance) smi_1766 PWY-6471 peptidoglycan biosynthesis IV (Enterococcus faecium) smi_1815 PWY-5480 pyruvate fermentation to ethanol I smi_1815 PWY-5485 pyruvate fermentation to acetate IV smi_1815 PWY-5493 reductive monocarboxylic acid cycle smi_1823 PWY-5101 L-isoleucine biosynthesis II smi_1823 PWY-5103 L-isoleucine biosynthesis III smi_1823 PWY-5104 L-isoleucine biosynthesis IV smi_1823 PWY-7111 pyruvate fermentation to isobutanol (engineered) smi_1824 PWY-5101 L-isoleucine biosynthesis II smi_1824 PWY-5103 L-isoleucine biosynthesis III smi_1824 PWY-5104 L-isoleucine biosynthesis IV smi_1824 PWY-5938 (R)-acetoin biosynthesis I smi_1824 PWY-5939 (R)-acetoin biosynthesis II smi_1824 PWY-6389 (S)-acetoin biosynthesis smi_1824 PWY-7111 pyruvate fermentation to isobutanol (engineered) smi_1825 PWY-5101 L-isoleucine biosynthesis II smi_1825 PWY-5103 L-isoleucine biosynthesis III smi_1825 PWY-5104 L-isoleucine biosynthesis IV smi_1825 PWY-5938 (R)-acetoin biosynthesis I smi_1825 PWY-5939 (R)-acetoin biosynthesis II smi_1825 PWY-6389 (S)-acetoin biosynthesis smi_1825 PWY-7111 pyruvate fermentation to isobutanol (engineered) smi_1845 PWY-6545 pyrimidine deoxyribonucleotides de novo biosynthesis III smi_1845 PWY-7176 UTP and CTP de novo biosynthesis smi_1845 PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I smi_1845 PWY-7187 pyrimidine deoxyribonucleotides de novo biosynthesis II smi_1845 PWY-7197 pyrimidine deoxyribonucleotide phosphorylation smi_1845 PWY-7198 pyrimidine deoxyribonucleotides de novo biosynthesis IV smi_1845 PWY-7205 CMP phosphorylation smi_1845 PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP smi_1845 PWY-7220 adenosine deoxyribonucleotides de novo biosynthesis II smi_1845 PWY-7221 guanosine ribonucleotides de novo biosynthesis smi_1845 PWY-7222 guanosine deoxyribonucleotides de novo biosynthesis II smi_1845 PWY-7224 purine deoxyribonucleosides salvage smi_1845 PWY-7226 guanosine deoxyribonucleotides de novo biosynthesis I smi_1845 PWY-7227 adenosine deoxyribonucleotides de novo biosynthesis smi_1850 PWY-6749 CMP-legionaminate biosynthesis I smi_1884 PWY-7219 adenosine ribonucleotides de novo biosynthesis smi_1908 PWY-7193 pyrimidine ribonucleosides salvage I smi_1912 PWY-7187 pyrimidine deoxyribonucleotides de novo biosynthesis II smi_1912 PWY-7220 adenosine deoxyribonucleotides de novo biosynthesis II smi_1912 PWY-7222 guanosine deoxyribonucleotides de novo biosynthesis II smi_1917 PWY-2161 folate polyglutamylation smi_1967 PWY-4983 L-citrulline-nitric oxide cycle smi_1967 PWY-4984 urea cycle smi_1967 PWY-5 canavanine biosynthesis smi_1967 PWY-5154 L-arginine biosynthesis III (via N-acetyl-L-citrulline) smi_1967 PWY-7400 L-arginine biosynthesis IV (archaebacteria) smi_1968 PWY-4983 L-citrulline-nitric oxide cycle smi_1968 PWY-4984 urea cycle smi_1968 PWY-5 canavanine biosynthesis smi_1968 PWY-5154 L-arginine biosynthesis III (via N-acetyl-L-citrulline) smi_1968 PWY-7400 L-arginine biosynthesis IV (archaebacteria) smi_1996 PWY-6902 chitin degradation II smi_2021 PWY-6807 xyloglucan degradation II (exoglucanase) smi_2034 PWY-4261 glycerol degradation I smi_2034 PWY-6118 glycerol-3-phosphate shuttle smi_2034 PWY-6952 glycerophosphodiester degradation smi_2035 PWY-4261 glycerol degradation I smi_2060 PWY-6936 seleno-amino acid biosynthesis smi_2069 PWY-5269 cardiolipin biosynthesis II smi_2069 PWY-5668 cardiolipin biosynthesis I smi_2075 PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation smi_2075 PWY-6596 adenosine nucleotides degradation I smi_2075 PWY-7221 guanosine ribonucleotides de novo biosynthesis