LOCUS       NC_015756              18992 bp    DNA     circular CON 08-JUN-2013
DEFINITION  Weissella koreensis KACC 15510 plasmid WKp2903, complete sequence.
ACCESSION   NC_015756
VERSION     NC_015756.1  GI:339635250
DBLINK      Project: 68837
            BioProject: PRJNA68837
KEYWORDS    RefSeq.
SOURCE      Weissella koreensis KACC 15510
  ORGANISM  Weissella koreensis KACC 15510
            Bacteria; Firmicutes; Bacilli; Lactobacillales; Leuconostocaceae;
            Weissella.
REFERENCE   1  (bases 1 to 18992)
  AUTHORS   Lee,S.H., Jung,J.Y., Lee,S.H. and Jeon,C.O.
  TITLE     Complete genome sequence of Weissella koreensis KACC 15510,
            isolated from kimchi
  JOURNAL   J. Bacteriol. 193 (19), 5534 (2011)
   PUBMED   21914863
REFERENCE   2  (bases 1 to 18992)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (06-JUL-2011) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 18992)
  AUTHORS   Lee,S.H. and Jeon,C.O.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-JUN-2011) Life Science and Research Center for
            Biomolecules and Bioscience, Chung-ang University, 221
            Heuksuk-dong, Dongjak-gu, Seoul 156-756, Republic of Korea
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to CP002900.
            Annotation was added by the NCBI Prokaryotic Genomes Automatic
            Annotation Pipeline Group. Information about the Pipeline can be
            found here:
            http://www.ncbi.nlm.nih.gov/genomes/static/Pipeline.html. Please be
            aware that the annotation is done automatically with little or no
            manual curation.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..18992
                     /organism="Weissella koreensis KACC 15510"
                     /mol_type="genomic DNA"
                     /strain="KACC 15510"
                     /isolation_source="kimchi"
                     /culture_collection="KACC:15510"
                     /db_xref="taxon:1045854"
                     /plasmid="WKp2903"
     gene            618..1172
                     /locus_tag="WKK_06852"
                     /db_xref="GeneID:10963519"
     CDS             618..1172
                     /locus_tag="WKK_06852"
                     /note="COG1961 Site-specific recombinases, DNA invertase
                     Pin homologs"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA invertase-like protein"
                     /protein_id="REF_WKK:WKK_06852"
                     /protein_id="YP_004717950.1"
                     /db_xref="GI:339635251"
                     /db_xref="GeneID:10963519"
                     /translation="MKYGYARVSTTDQKLENQIENLKKSGAEIIYKEKFTGTTTERPE
                     FNKLLNELKTDDTLIVTKLDRFARNTREALDIIEDLFKRDIKINILNMGIIDNTPTGQ
                     LIFTIFSAFAQFERDMIVTRTHEGKEYAKRNDPYFHEGRPQTYTDEQIRLAYELRQQG
                     MTYKMIARKTGISERTQQRRFKDI"
     misc_feature    618..1160
                     /locus_tag="WKK_06852"
                     /note="multiple promoter invertase; Provisional; Region:
                     mpi; PRK13413"
                     /db_xref="CDD:184041"
     misc_feature    621..995
                     /locus_tag="WKK_06852"
                     /note="Serine Recombinase (SR) family, Resolvase and
                     Invertase subfamily, catalytic domain; members contain a
                     C-terminal DNA binding domain. Serine recombinases
                     catalyze site-specific recombination of DNA molecules by a
                     concerted, four-strand cleavage and...; Region: SR_ResInv;
                     cd03768"
                     /db_xref="CDD:239737"
     misc_feature    order(636..638,642..644,807..812,819..821)
                     /locus_tag="WKK_06852"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239737"
     misc_feature    642..644
                     /locus_tag="WKK_06852"
                     /note="catalytic nucleophile [active]"
                     /db_xref="CDD:239737"
     misc_feature    order(804..806,936..941,945..950,960..962)
                     /locus_tag="WKK_06852"
                     /note="Presynaptic Site I dimer interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239737"
     misc_feature    order(822..824,837..842,924..926,933..938,945..950,
                     957..959,966..968)
                     /locus_tag="WKK_06852"
                     /note="Synaptic Antiparallel dimer interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239737"
     misc_feature    order(891..899,924..929,936..941,948..950,960..962,
                     969..971,981..983)
                     /locus_tag="WKK_06852"
                     /note="Synaptic Flat tetramer interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239737"
     misc_feature    order(891..893,939..941,948..950,960..962,969..971,
                     981..983)
                     /locus_tag="WKK_06852"
                     /note="Synaptic Site I dimer interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239737"
     misc_feature    order(963..965,981..986)
                     /locus_tag="WKK_06852"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:239737"
     misc_feature    1035..1145
                     /locus_tag="WKK_06852"
                     /note="Helix-turn-helix domain of Hin and related
                     proteins; Region: HTH_Hin_like; cl17393"
                     /db_xref="CDD:266662"
     misc_feature    order(1038..1046,1140..1145)
                     /locus_tag="WKK_06852"
                     /note="DNA-binding interface [nucleotide binding]; DNA
                     binding site"
                     /db_xref="CDD:259851"
     gene            2098..3333
                     /locus_tag="WKK_06857"
                     /db_xref="GeneID:10963530"
     CDS             2098..3333
                     /locus_tag="WKK_06857"
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid mobilization protein, truncated"
                     /protein_id="REF_WKK:WKK_06857"
                     /protein_id="YP_004717951.1"
                     /db_xref="GI:339635252"
                     /db_xref="GeneID:10963530"
                     /translation="MAHLKKNTRGAVPGLAVHFERKTDHHTNKEIDVSKTYLNQELMA
                     DGSDMLSRFNARLNDVYCMKRDDVKALATWIVTLPEELAESPYEQQSAFFEATTNFLN
                     DRYGQENAVAAVVHYDETTPHLHYAFVPVVFDDKKARYKVSAKEVLTRHDLQTFHEDL
                     DQHLKKVLPFYERGILNNKTLPFENVAEIKKYNDQFNALKTELADIEDNIRAKQAVLK
                     ITDQALTEVDLAEKQIDAFKQDLSKNLFGKTVLKPDDLDRFKSVLATMKKATLQSQHE
                     TEELKQTLGQVKAQLADIQADYQNLKETHQALQKRQREQQQMDYAMRDMLKNDYGVDK
                     IAHTDVEARYVLYKLDHEKLTQNKKVAQSWLKTLTTARADPDTKIAPTRLDRGIEQVK
                     ALINRIIELTRDIFKGPSL"
     misc_feature    2098..2637
                     /locus_tag="WKK_06857"
                     /note="Plasmid recombination enzyme; Region: Mob_Pre;
                     pfam01076"
                     /db_xref="CDD:250345"
     misc_feature    2677..3048
                     /locus_tag="WKK_06857"
                     /note="polyhydroxyalkanoic acid synthase, PhaR subunit;
                     Region: phaR_Bmeg; TIGR02132"
                     /db_xref="CDD:131187"
     misc_feature    <2869..3195
                     /locus_tag="WKK_06857"
                     /note="BAF1 / ABF1 chromatin reorganizing factor; Region:
                     BAF1_ABF1; pfam04684"
                     /db_xref="CDD:113452"
     gene            3836..4990
                     /locus_tag="WKK_06862"
                     /db_xref="GeneID:10963520"
     CDS             3836..4990
                     /locus_tag="WKK_06862"
                     /note="COG5527 Protein involved in initiation of plasmid
                     replication"
                     /codon_start=1
                     /transl_table=11
                     /product="RepB protein"
                     /protein_id="REF_WKK:WKK_06862"
                     /protein_id="YP_004717952.1"
                     /db_xref="GI:339635253"
                     /db_xref="GeneID:10963520"
                     /translation="MSIIPESKTRQVHTLNELSKRKVVEHNSLITSIAKMDKTPLKMF
                     ELAVSLIDTENPPEDQTVYLSKRELFAFFQVDDSNKHSRFKEAVEKMQKQAFFQIKKE
                     QDKGFKFISIVPIPYVEWTDYNDEVKIEFHREIMPYLINLKNNFTQHALSDIAELNSK
                     YAIILYRWLSMNYNQYEHYSVKGGRREEQVESYRNPEISMRDLRQMTDTIDEYKRFDH
                     FEKRVLNEPLSEITKHTTFNVTYEKLKKGRSIDSIVFHITKKQVADDISYKLDDPVYI
                     EGKIRQEETEDMLTVKAIKSPYTKLLMEQFLLSYIDLTDTTILSGLQKNVYPLYDELK
                     ESRGLKGVKEHLAYIRDKQDDYSKKNIAKYLKKSIEQYLPIVKRQDIDHE"
     misc_feature    3863..4975
                     /locus_tag="WKK_06862"
                     /note="Protein involved in initiation of plasmid
                     replication [DNA replication, recombination, and repair];
                     Region: COG5527"
                     /db_xref="CDD:227814"
     misc_feature    3890..4606
                     /locus_tag="WKK_06862"
                     /note="Initiator Replication protein; Region: Rep_3;
                     pfam01051"
                     /db_xref="CDD:250324"
     misc_feature    4613..4978
                     /locus_tag="WKK_06862"
                     /note="Lactococcus lactis RepB C-terminus; Region:
                     L_lactis_RepB_C; pfam06430"
                     /db_xref="CDD:253726"
     gene            4983..5549
                     /locus_tag="WKK_06867"
                     /db_xref="GeneID:10963521"
     CDS             4983..5549
                     /locus_tag="WKK_06867"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical cytosolic protein"
                     /protein_id="REF_WKK:WKK_06867"
                     /protein_id="YP_004717953.1"
                     /db_xref="GI:339635254"
                     /db_xref="GeneID:10963521"
                     /translation="MSENLKTIRELAEELGVSKQAIQYHIKSLTNKTRQTNDKGIVVL
                     SLEEQHFIRSKVDKQTNKNKTNKQTNDKQTDKETKWDIHNYLISELDEVKKNRDKQLA
                     VKDKQLENKDSQIAQMQNLLDQQQRLALQDKQLLEEYKAEIKDLKALTMAPHDDGEKE
                     VTSDKQLEPENSTPESQPKPKKWWRFGK"
     misc_feature    <5001..5081
                     /locus_tag="WKK_06867"
                     /note="HTH DNA binding domain; Region: HTH_10; pfam04967"
                     /db_xref="CDD:113729"
     misc_feature    5292..5408
                     /locus_tag="WKK_06867"
                     /note="Protein of unknown function, DUF536; Region:
                     DUF536; pfam04394"
                     /db_xref="CDD:252566"
     gene            5663..5881
                     /locus_tag="WKK_06872"
                     /db_xref="GeneID:10963522"
     CDS             5663..5881
                     /locus_tag="WKK_06872"
                     /note="COG2963 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="ORFA of IS3-like IS"
                     /protein_id="REF_WKK:WKK_06872"
                     /protein_id="YP_004717954.1"
                     /db_xref="GI:339635255"
                     /db_xref="GeneID:10963522"
                     /translation="MIRYKKEFKQSLVEMHNQGRSYTDLSAEYGPSVDSIRNWVKLYA
                     VHEVDGEKWTQADVNALQKGKRQTSRRT"
     misc_feature    5663..5851
                     /locus_tag="WKK_06872"
                     /note="Transposase; Region: HTH_Tnp_1; cl17663"
                     /db_xref="CDD:266764"
     misc_feature    5663..>5791
                     /locus_tag="WKK_06872"
                     /note="Transposase and inactivated derivatives [DNA
                     replication, recombination, and repair]; Region: COG2963"
                     /db_xref="CDD:225511"
     gene            6092..6547
                     /locus_tag="WKK_06877"
                     /db_xref="GeneID:10963523"
     CDS             6092..6547
                     /locus_tag="WKK_06877"
                     /note="COG3682 Predicted transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="TcrY"
                     /protein_id="REF_WKK:WKK_06877"
                     /protein_id="YP_004717955.1"
                     /db_xref="GI:339635256"
                     /db_xref="GeneID:10963523"
                     /translation="MSTIVVNPHITDAEWEVMRVVWANGRVTSKEIISILKEKMDWKQ
                     ATIKTLLGRLVEKGVLNTEQEGRKFIYTTNIEEKEAVGNYTDDIFNRICRKNVGNVVG
                     SIIEDHVLSFDDIQRLEEILEMKKAFAVEEVDCQCTEGQCDCHLHHHGE"
     misc_feature    6119..6505
                     /locus_tag="WKK_06877"
                     /note="copper transport repressor, CopY/TcrY family;
                     Region: CopY_TcrY; TIGR02698"
                     /db_xref="CDD:131745"
     gene            6560..6712
                     /locus_tag="WKK_06882"
                     /db_xref="GeneID:10963524"
     CDS             6560..6712
                     /locus_tag="WKK_06882"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="REF_WKK:WKK_06882"
                     /protein_id="YP_004717956.1"
                     /db_xref="GI:339635257"
                     /db_xref="GeneID:10963524"
                     /translation="MENKSFAIEGVESVEVDLATKKAVLESQTEIDTETLNAALAETN
                     YSVLSA"
     misc_feature    <6578..6700
                     /locus_tag="WKK_06882"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     gene            6851..8929
                     /locus_tag="WKK_06887"
                     /db_xref="GeneID:10963525"
     CDS             6851..8929
                     /locus_tag="WKK_06887"
                     /note="COG2217 Cation transport ATPase"
                     /codon_start=1
                     /transl_table=11
                     /product="Cu2+-Cu+-Ag+-P-type ATPase"
                     /protein_id="REF_WKK:WKK_06887"
                     /protein_id="YP_004717957.1"
                     /db_xref="GI:339635258"
                     /db_xref="GeneID:10963525"
                     /translation="MRNNKQHSSHSHHNHGDMDHSKHDHNEMEHSQMDHGKMNHSAMD
                     HSEMDHGGHMMHMGDMSKKLKVAIILMIPLLLISPIAGFTILKFPGSEILQLILGTII
                     FFYSGTPFFSGAKGELKSRKPAMMMLITMGITVAYTYSVYATIMSLNGHMGMNFWFEL
                     ATLIVIMLIGHLIEMKAIMGAGDALKDLASLVPKKAHLKSGKDVELSELKVGDLLLVK
                     ENERIPADGLILSEAFVDESMITGESRAVNKKTNDLVYGGSLNQNQPFEMKVTTLGKD
                     SFLNQVAELVKKAQAQKSNLENMADRVAGYLFYAALIVGIFSLIFWTISSNFSFALLL
                     AVSVFVIACPHALGLAVPLVVSRLTSISAKNGLLIQNRTSLEKINTIKYALMDKTGTL
                     TDGNFIVRNVINFTDETDILQIMAALEGSSTHPIAQSIVSAAKPLENLKVEAVENIPG
                     VGIKGQVNQNFYQIVNYKYLRENQLSYDEQKIAQYLDLGLTVSFLINEQQDVLGFIAL
                     GDSPKADAKAFINGLLAQGITPVMLTGDNKETAQKIASALNIPEFRAELKPEDKAEIV
                     KEYQKKAGVLFIGDGVNDSPALATATIGFAIGAGTSVAISTADVVLVNSNPSDVLDMI
                     NISKRMLRKMKQNLWFGAGYNIIAIPVAAGILYPFTGIYIDPLIAAVLMSISTVIVAI
                     NAMGLRYDKK"
     misc_feature    6905..8926
                     /locus_tag="WKK_06887"
                     /note="Cation transport ATPase [Inorganic ion transport
                     and metabolism]; Region: ZntA; COG2217"
                     /db_xref="CDD:225127"
     misc_feature    7337..7981
                     /locus_tag="WKK_06887"
                     /note="E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122"
                     /db_xref="CDD:249606"
     misc_feature    <8390..8614
                     /locus_tag="WKK_06887"
                     /note="haloacid dehalogenase-like hydrolase; Region: HAD;
                     pfam12710"
                     /db_xref="CDD:257240"
     gene            complement(9011..9538)
                     /locus_tag="WKK_06892"
                     /db_xref="GeneID:10963526"
     CDS             complement(9011..9538)
                     /locus_tag="WKK_06892"
                     /codon_start=1
                     /transl_table=11
                     /product="ATPase involved in DNA repair"
                     /protein_id="REF_WKK:WKK_06892"
                     /protein_id="YP_004717958.1"
                     /db_xref="GI:339635259"
                     /db_xref="GeneID:10963526"
                     /translation="MSQNKEAENLDDIFLIKDKNKPKTNKERSSEEKARETKQIVDNL
                     KKMQDPGKRWNEEQKNEVHYERNGLVRFESLTKQKLRKIKRGKSYQVFMENIDIYLDS
                     NEVKLEIKKLLQDTKDYLLQGVFDVFDANRYLRGNIYFLVHKGSQLNDYERKILKSFK
                     NKPYLKISLQSLVFV"
     gene            9907..10551
                     /locus_tag="WKK_06897"
                     /db_xref="GeneID:10963527"
     CDS             9907..10551
                     /locus_tag="WKK_06897"
                     /note="COG0640 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="putative transcriptional regulator"
                     /protein_id="REF_WKK:WKK_06897"
                     /protein_id="YP_004717959.1"
                     /db_xref="GI:339635260"
                     /db_xref="GeneID:10963527"
                     /translation="MFEQAVNYKNGLYKELSKIGKGLSSDRRLEILDLLTQAPKSVET
                     IANGVGISVANASRHLQILKDSHLVKTKRKGNHIIYSLSSPKISDFVHLLTDIGNSEL
                     SDMKTIQDKSDAQDNVKTISLKQAQEEYKNSFVLDVRPSDEYAAGHIQSAINVPLETL
                     KESMPKLPKDQKIIVYCRGRLCANSNIATQILNRNGFDAVSLNSSYYDWNKITE"
     misc_feature    9964..10197
                     /locus_tag="WKK_06897"
                     /note="Arsenical Resistance Operon Repressor and similar
                     prokaryotic, metal regulated homodimeric repressors. ARSR
                     subfamily of helix-turn-helix bacterial transcription
                     regulatory proteins (winged helix topology). Includes
                     several proteins that appear to...; Region: HTH_ARSR;
                     cd00090"
                     /db_xref="CDD:238042"
     misc_feature    order(9964..9969,9973..9975,9982..9984,9991..9996,
                     10003..10008,10015..10017,10105..10107,10171..10176,
                     10180..10188,10192..10197)
                     /locus_tag="WKK_06897"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238042"
     misc_feature    order(9967..9972,9982..9990,10027..10035,10060..10071,
                     10075..10080,10087..10092,10096..10101,10117..10125,
                     10138..10146)
                     /locus_tag="WKK_06897"
                     /note="putative DNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:238042"
     misc_feature    order(10027..10029,10036..10038,10171..10173)
                     /locus_tag="WKK_06897"
                     /note="putative Zn2+ binding site [ion binding]; other
                     site"
                     /db_xref="CDD:238042"
     misc_feature    10297..10533
                     /locus_tag="WKK_06897"
                     /note="Rhodanese Homology Domain (RHOD); an alpha beta
                     fold domain found duplicated in the rhodanese protein. The
                     cysteine containing enzymatically active version of the
                     domain is also found in the Cdc25 class of protein
                     phosphatases and a variety of proteins...; Region: RHOD;
                     cd00158"
                     /db_xref="CDD:238089"
     misc_feature    10435..10437
                     /locus_tag="WKK_06897"
                     /note="active site residue [active]"
                     /db_xref="CDD:238089"
     gene            10677..10958
                     /locus_tag="WKK_06902"
                     /db_xref="GeneID:10963528"
     CDS             10677..10958
                     /locus_tag="WKK_06902"
                     /note="COG0526 Thiol-disulfide isomerase and thioredoxins"
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="REF_WKK:WKK_06902"
                     /protein_id="YP_004717960.1"
                     /db_xref="GI:339635261"
                     /db_xref="GeneID:10963528"
                     /translation="MSTIDKTLTLINFENNWCAQCYTQRPIINKISHDFNSYLNVRVV
                     NSDAHPEPAKKYNVYSAPSTILLRDGKIVEKITRFIDQSQLTTLIKYYL"
     misc_feature    10689..10946
                     /locus_tag="WKK_06902"
                     /note="TRX family; composed of two groups: Group I, which
                     includes proteins that exclusively encode a TRX domain;
                     and Group II, which are composed of fusion proteins of TRX
                     and additional domains. Group I TRX is a small ancient
                     protein that alter the redox...; Region: TRX_family;
                     cd02947"
                     /db_xref="CDD:239245"
     misc_feature    order(10728..10730,10737..10739)
                     /locus_tag="WKK_06902"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239245"
     gene            10972..11286
                     /locus_tag="WKK_06907"
                     /db_xref="GeneID:10963529"
     CDS             10972..11286
                     /locus_tag="WKK_06907"
                     /note="COG0526 Thiol-disulfide isomerase and thioredoxins"
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="REF_WKK:WKK_06907"
                     /protein_id="YP_004717961.1"
                     /db_xref="GI:339635262"
                     /db_xref="GeneID:10963529"
                     /translation="MVKNLTDKDFVKETSTGVTLTDFWATWCPPCRMQGPIIEQLDKE
                     IGDKVKITKIDVDANQKTPIAFGIMSIPTLIIKKDGQVVDKLVGLHSKDQLKTVLAQY
                     TN"
     misc_feature    11011..11271
                     /locus_tag="WKK_06907"
                     /note="TRX family; composed of two groups: Group I, which
                     includes proteins that exclusively encode a TRX domain;
                     and Group II, which are composed of fusion proteins of TRX
                     and additional domains. Group I TRX is a small ancient
                     protein that alter the redox...; Region: TRX_family;
                     cd02947"
                     /db_xref="CDD:239245"
     misc_feature    order(11053..11055,11062..11064)
                     /locus_tag="WKK_06907"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239245"
     gene            11307..11630
                     /locus_tag="WKK_06912"
                     /db_xref="GeneID:10963509"
     CDS             11307..11630
                     /locus_tag="WKK_06912"
                     /note="COG0526 Thiol-disulfide isomerase and thioredoxins"
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin"
                     /protein_id="REF_WKK:WKK_06912"
                     /protein_id="YP_004717962.1"
                     /db_xref="GI:339635263"
                     /db_xref="GeneID:10963509"
                     /translation="MEQLSVMNKKEFDKKLKNGKYILVFMASWCPDCSFIKPHLPEIE
                     QEFKDYTFISVDRDENTELAQELNIFGIPSFVIFRDGQEIGRLVNKDRKTKEEVENFI
                     TNTIN"
     misc_feature    11334..11612
                     /locus_tag="WKK_06912"
                     /note="TRX family; composed of two groups: Group I, which
                     includes proteins that exclusively encode a TRX domain;
                     and Group II, which are composed of fusion proteins of TRX
                     and additional domains. Group I TRX is a small ancient
                     protein that alter the redox...; Region: TRX_family;
                     cd02947"
                     /db_xref="CDD:239245"
     misc_feature    order(11394..11396,11403..11405)
                     /locus_tag="WKK_06912"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239245"
     gene            11849..12793
                     /locus_tag="WKK_06917"
                     /db_xref="GeneID:10963510"
     CDS             11849..12793
                     /locus_tag="WKK_06917"
                     /note="COG0492 Thioredoxin reductase"
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin reductase"
                     /protein_id="REF_WKK:WKK_06917"
                     /protein_id="YP_004717963.1"
                     /db_xref="GI:339635264"
                     /db_xref="GeneID:10963510"
                     /translation="MRKYDVVVIGAGPGGMTAALYAARANLNVAMLDRGIYGGQMNNT
                     DDIENYPGFTTIKGPELGEKMYQGTVKAGVNFVYGDVQNVTVDDQQMKHIQTDSDELV
                     ASAVIIATGSNNRKLGVPGEENFSGKGVSYCAVCDGSFFKGKNVTVVGGGDSAISEGL
                     YLANVTDGVNVIHRRDQLRAQKVLQNRAFDNDKIDFTWNTSVTEILGDENHVTGVKIH
                     NNQVGDDTTLDTDGVFVYVGNFPNSQIFNNLNITDQAGWIITNDQMETTIPGIYAIGD
                     VRQKQLRQITTAVGDGGIAGQNAFEYFEAIKHRQTVKD"
     misc_feature    11861..12754
                     /locus_tag="WKK_06917"
                     /note="thioredoxin-disulfide reductase; Region:
                     TRX_reduct; TIGR01292"
                     /db_xref="CDD:233345"
     misc_feature    11867..12376
                     /locus_tag="WKK_06917"
                     /note="NAD(P)-binding Rossmann-like domain; Region:
                     NAD_binding_8; cl19134"
                     /db_xref="CDD:267487"
     misc_feature    12281..12478
                     /locus_tag="WKK_06917"
                     /note="Pyridine nucleotide-disulphide oxidoreductase;
                     Region: Pyr_redox; pfam00070"
                     /db_xref="CDD:249559"
     gene            12812..13459
                     /locus_tag="WKK_06922"
                     /db_xref="GeneID:10963511"
     CDS             12812..13459
                     /locus_tag="WKK_06922"
                     /note="COG2761 Predicted dithiol-disulfide isomerase
                     involved in polyketide biosynthesis"
                     /codon_start=1
                     /transl_table=11
                     /product="protein-disulfide isomerase"
                     /protein_id="REF_WKK:WKK_06922"
                     /protein_id="YP_004717964.1"
                     /db_xref="GI:339635265"
                     /db_xref="GeneID:10963511"
                     /translation="MEIKYWSDIACPFCYIGSNRMKRAMKEIGIYDTTELEFKSFELN
                     PATPKETDEGYINHFTQGNKAMEPQAKKQMAYIEQMAHNDGLPMDLDSVVPTNTMDAH
                     RIIKFAEAKNDPDLTERVIRRFYQVYFSDGQSISDHDVLLNAAMEAGLAKDEVEKVLN
                     SNQYHQAVVNDEAEAQQSGIHAAPFFVINNKYAISGAQPYEVFVKALKGVQAEEN"
     misc_feature    12818..13432
                     /locus_tag="WKK_06922"
                     /note="DsbA family, FrnE subfamily; FrnE is a DsbA-like
                     protein containing a CXXC motif. It is presumed to be a
                     thiol oxidoreductase involved in polyketide biosynthesis,
                     specifically in the production of the aromatic antibiotics
                     frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024"
                     /db_xref="CDD:239322"
     misc_feature    order(12842..12844,12851..12853)
                     /locus_tag="WKK_06922"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239322"
     gene            13472..13600
                     /locus_tag="WKK_06927"
                     /db_xref="GeneID:10963512"
     CDS             13472..13600
                     /locus_tag="WKK_06927"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="REF_WKK:WKK_06927"
                     /protein_id="YP_004717965.1"
                     /db_xref="GI:339635266"
                     /db_xref="GeneID:10963512"
                     /translation="MTEDKPQFNTIFGDNNDAAVCGPDGCNIAEHQKQTEDKKKTK"
     gene            13618..14949
                     /locus_tag="WKK_06932"
                     /db_xref="GeneID:10963513"
     CDS             13618..14949
                     /locus_tag="WKK_06932"
                     /note="COG1249 Pyruvate/2-oxoglutarate dehydrogenase
                     complex, dihydrolipoamide dehydrogenase (E3) component,
                     and related enzymes"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="REF_WKK:WKK_06932"
                     /protein_id="YP_004717966.1"
                     /db_xref="GI:339635267"
                     /db_xref="GeneID:10963513"
                     /translation="MKFDYVVIGSGPSVYRFLLGMQNSGKKIAVVEKNRFGGICPNEG
                     CEPKIFLEGAARATLTSMRLQGKGITQPAKLDWKELIQQKNKAMASFLNNMQSMYEGL
                     GATTIKGEASFVDQHTIEVNNKKITADNFVIATGKKPHPLNIPGHEYLLTSTNLFELE
                     DTPKNVAIIGSGYVGMEFATLLSAAGVKVTVIVRSGQPLEGFYSQHVHQLVDEMKNSL
                     GINFIFNTNVTAVTEAQTGYEVQSANGNLGTFDKVINASGRVPEINALKLDNAGVEYS
                     NRGIKVDKYLTTSANNIYAMGDIVDKTAPALTSTAQFEADYLSALLTNKTTEPLRYPV
                     IGTVTFTFPQLAQAGISIDKAKEDSNYSIKDIDITQGDFLYAGTDDHARLSLVFDKQN
                     HLVGAAEISQTAVDDINSLIPVMAIDVDPEVWKEKMLMAFPGLAYKIRTLI"
     misc_feature    13618..14925
                     /locus_tag="WKK_06932"
                     /note="Pyruvate/2-oxoglutarate dehydrogenase complex,
                     dihydrolipoamide dehydrogenase (E3) component, and related
                     enzymes [Energy production and conversion]; Region: Lpd;
                     COG1249"
                     /db_xref="CDD:224169"
     misc_feature    <13993..14202
                     /locus_tag="WKK_06932"
                     /note="NAD(P)-binding Rossmann-like domain; Region:
                     NAD_binding_8; cl19134"
                     /db_xref="CDD:267487"
     misc_feature    14110..14352
                     /locus_tag="WKK_06932"
                     /note="Pyridine nucleotide-disulphide oxidoreductase;
                     Region: Pyr_redox; pfam00070"
                     /db_xref="CDD:249559"
     gene            complement(15722..15853)
                     /locus_tag="WKK_06937"
                     /db_xref="GeneID:10963514"
     CDS             complement(15722..15853)
                     /locus_tag="WKK_06937"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="REF_WKK:WKK_06937"
                     /protein_id="YP_004717967.1"
                     /db_xref="GI:339635268"
                     /db_xref="GeneID:10963514"
                     /translation="MKRLSLNKDPKATTNAWGPLINTITHHGLNSLKKGEIKFDDLK"
     gene            complement(15861..16355)
                     /locus_tag="WKK_06942"
                     /db_xref="GeneID:10963515"
     CDS             complement(15861..16355)
                     /locus_tag="WKK_06942"
                     /note="COG1902 NADH:flavin oxidoreductases, Old Yellow
                     Enzyme family"
                     /codon_start=1
                     /transl_table=11
                     /product="putative NADH oxidase-related oxidoreductase
                     protein"
                     /protein_id="REF_WKK:WKK_06942"
                     /protein_id="YP_004717968.1"
                     /db_xref="GI:339635269"
                     /db_xref="GeneID:10963515"
                     /translation="MRILVEIYQGIRQVTKSNFIVGIKLNSSDFSSEGFSEDDSYRVI
                     VKMSNLGIDFIKISGGNYERTKFLENSNGEAFFLKFSKKSQVSVNIPIMLTGGLSSQE
                     AMENVVTNEGIAMVGSVRPFVLNPNSPEKMLSGIFEGLKLPHLTTGVKVIDNKLGHGG
                     SSIL"
     misc_feature    complement(15951..>16355)
                     /locus_tag="WKK_06942"
                     /note="TIM barrel proteins share a structurally conserved
                     phosphate binding motif and in general share an eight
                     beta/alpha closed barrel structure. Specific for this
                     family is the conserved phosphate binding site at the
                     edges of strands 7 and 8. The phosphate...; Region:
                     TIM_phosphate_binding; cl17186"
                     /db_xref="CDD:266538"
     misc_feature    complement(order(15996..16001,16065..16070))
                     /locus_tag="WKK_06942"
                     /note="phosphate binding site [ion binding]; other site"
                     /db_xref="CDD:240073"
     gene            complement(16463..16561)
                     /locus_tag="WKK_06947"
                     /db_xref="GeneID:10963516"
     CDS             complement(16463..16561)
                     /locus_tag="WKK_06947"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="REF_WKK:WKK_06947"
                     /protein_id="YP_004717969.1"
                     /db_xref="GI:339635270"
                     /db_xref="GeneID:10963516"
                     /translation="MTKEPVAPSVIPMPKNLRKLFNTPRELSKTGG"
     misc_feature    complement(<16475..>16561)
                     /locus_tag="WKK_06947"
                     /note="TIM barrel proteins share a structurally conserved
                     phosphate binding motif and in general share an eight
                     beta/alpha closed barrel structure. Specific for this
                     family is the conserved phosphate binding site at the
                     edges of strands 7 and 8. The phosphate...; Region:
                     TIM_phosphate_binding; cl17186"
                     /db_xref="CDD:266538"
     gene            complement(16736..17569)
                     /locus_tag="WKK_06952"
                     /db_xref="GeneID:10963517"
     CDS             complement(16736..17569)
                     /locus_tag="WKK_06952"
                     /note="COG0596 Predicted hydrolases or acyltransferases
                     (alpha/beta hydrolase superfamily)"
                     /codon_start=1
                     /transl_table=11
                     /product="hydrolase, alpha/beta fold family protein"
                     /protein_id="REF_WKK:WKK_06952"
                     /protein_id="YP_004717970.1"
                     /db_xref="GI:339635271"
                     /db_xref="GeneID:10963517"
                     /translation="MSYLQTKNQYITVEGLKIAYRELGQGKSQYPLVMLVHLAATMDN
                     WDPKLIDNLAEKNHIIVMDLPGVGASEGKIAESIPCMADQAIAIIKALGYQKINLLGL
                     SMGGFIAQEIVRLDANLVNTLTLAGTGPRAGIGVDKVTGVTFKHMANGFLHGADAKRY
                     IFYNPDKAGKVEAHKVLDRLASRPKDAKDKDMKVSSFLKQLKAIKSWGKAEQDTLDFI
                     KVPTFIVNGDNDVMVPTQNSYDMHEKIQDSKLIIYPDAGHGAIFQYAEEFVDELNNFL
                     N"
     misc_feature    complement(16742..17542)
                     /locus_tag="WKK_06952"
                     /note="Predicted hydrolases or acyltransferases
                     (alpha/beta hydrolase superfamily) [General function
                     prediction only]; Region: MhpC; COG0596"
                     /db_xref="CDD:223669"
     misc_feature    complement(<17243..17476)
                     /locus_tag="WKK_06952"
                     /note="Putative lysophospholipase; Region: Hydrolase_4;
                     cl19140"
                     /db_xref="CDD:267493"
     misc_feature    complement(16850..>17098)
                     /locus_tag="WKK_06952"
                     /note="Thioredoxin; Region: Thioredoxin_4; cl17273"
                     /db_xref="CDD:266602"
     misc_feature    complement(16790..>16957)
                     /locus_tag="WKK_06952"
                     /note="Putative lysophospholipase; Region: Hydrolase_4;
                     cl19140"
                     /db_xref="CDD:267493"
     gene            complement(17571..18578)
                     /locus_tag="WKK_06957"
                     /db_xref="GeneID:10963518"
     CDS             complement(17571..18578)
                     /locus_tag="WKK_06957"
                     /note="COG0604 NADPH:quinone reductase and related
                     Zn-dependent oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="zinc-binding dehydrogenase"
                     /protein_id="REF_WKK:WKK_06957"
                     /protein_id="YP_004717971.1"
                     /db_xref="GI:339635272"
                     /db_xref="GeneID:10963518"
                     /translation="MKAAQLTQYNKNNIKLELVDTPMPELGAQDVLVKVTAAGVNPVD
                     NMISRGQIKLLIPYKLPQIAGNEVVGIVEKVGTQVTGFKVGDRVFARMPLDRIGAFAE
                     YTAINYRALAHVPDYLTDVEAAAVPLTALTVMQALDLMGAKKGGTFFMTGGTGGVGAM
                     AIPIAKAKGLTVITNGNIDNKARIMALGLNRFIDYKTEDYTQTLSQVDYVLDTLGGAE
                     TEKQMSIMKKGGKLVNLSGMPNKAFAKRFGLPKWKQILFGLVGGKFDRMAKKYGVTYD
                     FVFVESNGAQLQEVADLFSQLKIKPSIDTVYNFSQINEALDKVANGRSRGKTVITFGE
                     K"
     misc_feature    complement(17583..18578)
                     /locus_tag="WKK_06957"
                     /note="NADPH:quinone reductase and related Zn-dependent
                     oxidoreductases [Energy production and conversion /
                     General function prediction only]; Region: Qor; COG0604"
                     /db_xref="CDD:223677"
     misc_feature    complement(17589..18578)
                     /locus_tag="WKK_06957"
                     /note="alcohol dehydrogenase and quinone reductase-like
                     medium chain degydrogenases/reductases; Region:
                     MDR_like_2; cd05289"
                     /db_xref="CDD:176191"
     misc_feature    complement(order(17739..17747,17871..17876,17937..17942,
                     17997..17999,18039..18041,18045..18050,18105..18122,
                     18183..18185,18195..18197,18441..18443,18450..18458))
                     /locus_tag="WKK_06957"
                     /note="putative NAD(P) binding site [chemical binding];
                     other site"
                     /db_xref="CDD:176191"
CONTIG      join(CP002900.1:1..18992)
ORIGIN      
        1 tttagtatcc attattttct attttccttt ttgttgtatc agattcaggt acaagtatat
       61 atagatattt tctaatgtca acaattttga ctcattatta ccaataatac ttagacgtat
      121 tggttcgtaa cctatagcat aactttttat ttttatggat aaattttgga tccaccttaa
      181 attccacttc acttacaaaa aataaggtgt aaaatcctta taaaacaaaa agtgatctaa
      241 ggaatttctc ttagattact tttggactct ctgccaaatc ctgtcgatgg actgtaattg
      301 gatagtataa agataaaact aaataaaagt cgtggagata accctcaaaa ttgaaccaaa
      361 ttccaatctg gggttagcct catttgtaat tcttctgctc gtatactgaa aatccggact
      421 gctttatttc tagggcataa tccgagataa tcaagtatag gagtttaata ggcgtcataa
      481 ctcaacagtt gtgtcgcctt tttttgtgcc ttataattaa aggtgttaga atgcgtcata
      541 acttaccgcc ataaatacag acccttttta ctgcaaaagt accaaatttg ctatataaaa
      601 cagattggag aaataatatg aaatatggtt atgcacgagt gagcaccacc gatcaaaaac
      661 tagaaaatca aattgagaac ttaaaaaaat caggcgctga aataatctat aaagaaaagt
      721 ttactggtac gactactgaa cgtcccgaat ttaacaaatt gctgaatgaa cttaaaacag
      781 acgacacgct aattgtgaca aaactagacc gctttgcacg caatactaga gaagcccttg
      841 atataattga agacctattt aaacgtgaca tcaaaattaa tatccttaac atgggaataa
      901 ttgataatac acccacagga caattgattt ttacaatttt tagcgccttt gcgcaatttg
      961 aacgagatat gattgtgaca agaacacatg agggaaaaga atatgccaaa aggaacgacc
     1021 cttattttca tgagggacgc ccacaaacct acacagatga acaaatacgt ttagcctatg
     1081 agttgcgtca acaaggcatg acatacaaaa tgattgctag aaaaacaggc ataagtgaac
     1141 gaacgcaaca aagacgattt aaagatatat gatagcatat catgatgtgc tatgttgtta
     1201 atgccagcta aattataccg tgaaccctct atcaaaagtt gcccacttta ctagcatacg
     1261 aacaaattgt gtgagaaaat tattgactta acttgattca tcttatgaaa acaaaaaaat
     1321 atcacaataa aatatgtcta caagtttaaa cgtatcgtat caagctatat ctaattggga
     1381 acgtgggaaa agttatccgg atatctccaa tattattatg atttcagatt tgtacaatat
     1441 ttcattggat gaactgatta gagaagataa aaactataaa gacatgttac ttgaaaagaa
     1501 agtatcaggc atcgtcgata cgatacttaa tgttattttt ttcttgtgcg ctgtaatgat
     1561 attaatttac atgattatcg aaaataaact cacctcagca aattcttttt atatcattct
     1621 ggcaatctta gttataatcc ataccagcat tgatttatta aaattgttac caaaaaaaac
     1681 gtgtagtttg ctcacaggga attttggatt caaattaata cgatgaggga catatcagca
     1741 ttcaaaataa gttgagatag atacagatac tatctcaact tattttttat gtggttaagc
     1801 tgacaccagc ttgccccacg cgggtagcgt tctgcatgac atgctctcac tgaaagtgat
     1861 cctgcaatga taaattgccc cgtcacggcg tgacccgccg gaggttttac aagccggata
     1921 agtggcgctg taaaatagca gtttccccag tacgaagggg aaaagctacg gtcatcgctt
     1981 gtcgatgaca cgcctcgcag agcctgtcca aaatattatt ttggtataac aggctatacc
     2041 agatttttaa cggtgttata ctggtcttgg aaaacctttt ttgaggaggc atttttgatg
     2101 gcgcatttaa agaaaaatac ccgtggcgca gtacccggtt tagcggttca ctttgaacgt
     2161 aaaaccgatc atcacaccaa caaagaaatt gatgtgtcga aaacctatct gaatcaagag
     2221 ctcatggctg atggttctga tatgctttca cgcttcaatg cgcgtttaaa tgacgtttat
     2281 tgcatgaaaa gagacgatgt aaaggcgtta gcgacttgga ttgtcacttt acctgaagaa
     2341 ctcgcagaat cgccctacga gcaacagagc gccttttttg aagcaaccac taattttttg
     2401 aatgaccgtt atggtcaaga aaatgccgtg gccgctgtcg tgcattatga cgagacaacc
     2461 cctcacttgc actatgcctt tgtcccggta gtttttgatg ataaaaaggc acgttataaa
     2521 gtatccgcta aagaagtgct cacgcgtcat gatctgcaaa cctttcatga ggatttagat
     2581 cagcatttaa aaaaggtgct acccttttat gaacgaggga ttttaaataa caaaacctta
     2641 ccgtttgaga atgtcgctga aatcaaaaaa tacaatgatc agtttaatgc cttaaaaacg
     2701 gaactagccg atattgaaga caacattcgt gcgaaacagg cagtacttaa aatcacggat
     2761 caagccttaa cggaagtaga cttagccgaa aaacaaattg atgcctttaa acaagactta
     2821 tctaaaaacc tctttggtaa gacggtgctt aaacctgatg acttagatcg ctttaaaagt
     2881 gtgttagcca cgatgaagaa agccaccttg caaagccagc atgagacgga agaactcaag
     2941 caaacgttag gccaagtcaa agcgcaatta gctgacatcc aagctgatta tcaaaaccta
     3001 aaagaaacgc atcaagcgct acagaagcgg caacgagaac agcaacagat ggattatgct
     3061 atgcgtgaca tgcttaaaaa tgattatggt gtcgacaaga tagcccatac tgatgtggag
     3121 gcccggtatg ttctttataa gctggatcat gaaaaactca ctcaaaataa aaaagtagcc
     3181 cagtcctggt taaaaacact gacgacagct agagcagatc cagatacgaa aatagcgcca
     3241 actagattag atcgcggtat tgaacaagtt aaagcattaa tcaatcgaat cattgaatta
     3301 acgcgtgata tttttaaggg gccaagtctg taacgttata acggcttatt tgcccgtata
     3361 agccttttta gccatgtgac gtagaaataa tcattaaata gattaaaacg tcgctattgg
     3421 cttaataagt ggcaatctat gttagataac taggtatccg gcatttgaaa tgattcaaaa
     3481 caaaaagaac actctgtacg aaatttatgt gcaccagtgt tctttttgtt ttgtttttta
     3541 ttgaatcaat aaaaaggcgg agcctattat aagtttatct tttatatttt aatcttttgt
     3601 tcttttgcgc agttataaag tcagtattat caagggttta caagattatg tacccacaaa
     3661 aaactatgta tacacccaca aaatactatg tatacaccca caaaatacta tgtatacacc
     3721 cacttctcat ttagataagt gggtgtatag gttataataa aaagcataaa gaaattcccg
     3781 actaaaagtt tttctttata cttatccaac aacacgccca aaggagcgta tttatatgtc
     3841 aattatacca gaatcaaaga caaggcaggt acacaccttg aatgagttat caaaacgaaa
     3901 agtcgtcgaa cataacagtt taatcacttc aattgccaaa atggataaga caccactcaa
     3961 aatgtttgag ttggccgttt ctctaataga tacggaaaat ccccccgaag atcagacggt
     4021 ttatttatca aagcgagagt tgtttgcttt ttttcaagtt gatgatagca acaaacatag
     4081 tcgttttaaa gaagccgttg aaaaaatgca gaaacaagct ttttttcaga ttaaaaaaga
     4141 acaagataaa ggctttaaat ttattagtat tgtaccgatc ccgtatgtgg aatggacaga
     4201 ttataatgac gaagtaaaaa ttgaatttca tcgtgaaatt atgccttatc taattaatct
     4261 caaaaataat tttacgcaac atgctttgtc agatattgca gaattgaaca gtaagtatgc
     4321 aataattttg tatcgttggt tatcgatgaa ttacaatcaa tacgagcatt acagcgttaa
     4381 aggtggacgg agagaggaac aggttgaaag ttaccgtaat cccgaaataa gcatgcgaga
     4441 tttacgtcaa atgacagata caattgatga atataaacga tttgatcatt ttgaaaaaag
     4501 agtactgaat gaaccattgt cagaaattac taaacacaca actttcaatg taacttacga
     4561 aaagctcaaa aaagggcgga gtattgatag tattgtcttt catatcacta aaaaacaagt
     4621 ggcagatgat attagttaca agctagatga tcccgtttat atcgagggca agatccgtca
     4681 agaagaaaca gaagatatgt tgactgttaa ggcaataaaa agtccctata caaagttact
     4741 tatggagcag tttttattgt catatattga tttaacggat actactattt tgtcagggtt
     4801 acagaaaaat gtttatccac tttatgacga attaaaagag tcacgtggtt taaagggcgt
     4861 gaaagaacac ttagcctata tcagagacaa acaagatgac tattcgaaaa agaatattgc
     4921 taagtatctt aaaaaatcga ttgaacagta tctaccaatc gttaaaaggc aggatataga
     4981 tcatgagtga aaatttaaaa acaattcgag aacttgctga ggagttaggt gtttcaaaac
     5041 aggcgataca atatcatata aagtcgctga caaacaaaac aaggcaaaca aacgacaaag
     5101 gtatagttgt tttatcttta gaagaacagc attttataag gtctaaggtc gacaaacaga
     5161 caaacaaaaa caagacaaat aaacagacaa atgacaaaca aacagacaaa gagacaaagt
     5221 gggatatcca caactattta attagtgaac ttgatgaagt taagaaaaat agagataaac
     5281 aattagcagt taaggataag caactagaaa ataaagattc gcaaatagct caaatgcaaa
     5341 acttactaga ccagcaacaa cggctagcct tacaggacaa gcaactgctc gaagaataca
     5401 aggcagaaat taaggacttg aaagccttaa cgatggcacc gcatgatgat ggtgaaaaag
     5461 aagtgacgtc agacaaacaa ctggaacctg aaaatagcac cccggagtca caacctaaac
     5521 ctaaaaagtg gtggcgtttt ggtaaatagt tacaactaaa aaagaaaaga agactagtta
     5581 aatggcggga tgctcttatg ctagatttac ggacagattt tcttctgccc tgtaaactaa
     5641 tagcatagga gcatttttta atatgattcg atacaaaaaa gaatttaagc agtctcttgt
     5701 tgagatgcac aatcaaggcc gttcatatac tgatctatcc gctgaatacg gaccttcggt
     5761 cgactcaatc cgtaactggg tcaagttgta cgcggtccac gaagtggacg gcgaaaaatg
     5821 gacgcaagct gatgtaaacg cattacaaaa aggaaaacga caaacttcgc gaagaacttg
     5881 agattttaaa aataaggaat tctaaaatca ataaaagtaa atcaatggta accttataat
     5941 tagtattggg taaagatagg aaaacaaagg caataatagc tggttacatt tatttaaaaa
     6001 agacttgaca agaatggttt acaatagtaa acttatctca aacgtttacg tttacgcatg
     6061 tagacaataa ggagggaagg agggaaagag aatgagtaca atagtagtta accctcatat
     6121 cacagatgct gaatgggaag ttatgcgtgt agtctgggcg aatggtcgag tgactagtaa
     6181 agaaatcatc tccatattga aagaaaaaat ggactggaaa caagccacta tcaaaacgct
     6241 cttaggtcga ctggttgaaa aaggcgtact aaatacagag caagaaggta gaaaatttat
     6301 ttatactacc aatattgaag agaaagaagc cgtaggaaat tatacagacg atattttcaa
     6361 ccgtatttgt cgaaagaatg tcgggaatgt agtagggagt atcattgaag atcatgtctt
     6421 aagcttcgat gatatccagc gactagaaga aatattagag atgaaaaaag ctttcgcagt
     6481 agaagaagtg gattgtcagt gtacagaagg gcaatgcgat tgccatttac atcatcatgg
     6541 agaataagta gcgaaaaaat tggagaataa atcgtttgcc atagaagggg ttgaatctgt
     6601 agaggttgat ttagcgacta aaaaagcagt acttgaaagt caaacagaga ttgataccga
     6661 aacgctcaat gctgctttag cagaaactaa ctattcagta ttaagtgcat aaagtacgaa
     6721 taccatttat tcatagatag tagatagaga taaagtatag aacccttttc atgagaatta
     6781 tatgcagtgt tagatgagaa aattctaaaa ctttaaaatc agtctctaat ataataagga
     6841 ggaattaaaa atgaggaata acaaacaaca ttcgtcacat agtcatcata atcacggcga
     6901 catggatcac tcaaaacacg accataatga aatggaacat agtcagatgg atcacggcaa
     6961 gatgaatcat agtgcgatgg atcacagtga aatggatcat ggaggacaca tgatgcatat
     7021 gggtgatatg agtaaaaagc tcaaagtggc tatcattctt atgattccgc ttctactcat
     7081 ttcaccaatc gcgggcttta ctatccttaa attccccgga agtgaaattt tgcaacttat
     7141 ccttggtaca attatcttct tttactctgg gactcctttt tttagcggag caaaaggtga
     7201 attaaaaagc cgtaagccag ccatgatgat gctgattaca atgggaatta ccgttgccta
     7261 tacttattct gtttatgcca caattatgag tcttaacgga catatgggca tgaacttctg
     7321 gtttgaactg gcaactttaa ttgtcattat gttgattggt cacctgattg agatgaaagc
     7381 aatcatgggt gctggcgatg cattgaaaga tttagcaagc cttgttccca aaaaagctca
     7441 cttaaaaagt gggaaggatg tggagctttc agaactaaaa gttggcgatt tgcttttagt
     7501 gaaagaaaat gaaagaattc ctgcagatgg ccttatatta agtgaagcgt tcgttgatga
     7561 gtcaatgatt actggtgaaa gccgagcagt caataaaaaa acaaatgacc ttgtttatgg
     7621 tggttccctc aatcaaaacc aaccatttga gatgaaagtc acaacccttg gaaaagattc
     7681 atttctcaat caagtggccg aattagtcaa gaaagcccaa gctcaaaaat ctaatttgga
     7741 aaatatggct gacagagtgg ctggttacct tttctatgct gcacttattg tcggtatctt
     7801 ctcattaatt ttttggacaa ttagttctaa ctttagtttt gctcttcttc ttgcggtttc
     7861 tgtttttgta attgcatgtc cacacgcttt aggtcttgcg gttccacttg ttgtttctcg
     7921 cttaaccagt atttctgcta aaaatggttt attaattcag aacagaacct ctttggaaaa
     7981 aataaataca attaaatatg ccttaatgga taaaacagga acattaactg acggtaattt
     8041 tattgtccgt aatgttatta attttactga tgaaacagac attctccaaa tcatggcagc
     8101 acttgaagga agttccactc acccgattgc tcaatcaatc gtttcagctg ctaaacctct
     8161 tgaaaatcta aaagttgaag cggttgaaaa tattccagga gttggaatta aagggcaagt
     8221 taatcaaaac ttttatcaaa ttgttaacta taaatatctt cgtgaaaatc aactttctta
     8281 tgatgaacaa aagattgctc aatatttaga tttaggttta actgtatctt tcctaatcaa
     8341 tgaacaacaa gatgttttag gatttattgc cttaggagat tctcctaaag cagacgcgaa
     8401 agcctttatt aatggtttat tagcccaagg aattacccct gttatgctca cgggtgataa
     8461 taaagaaact gctcaaaaaa ttgctagtgc actaaatatt cccgaattta gagcggaatt
     8521 aaaacctgaa gataaagcag aaattgtgaa agaataccaa aagaaagccg gcgttctttt
     8581 cattggtgat ggtgtcaatg attccccagc tcttgcaact gctacgattg gttttgcgat
     8641 tggagcagga acttcggttg ctatcagtac cgctgatgtc gtcctagtta actccaatcc
     8701 aagtgacgtc ctggatatga ttaatatctc caaacgtatg cttagaaaaa tgaaacaaaa
     8761 cctctggttt ggagcaggct ataacatcat tgctattcct gttgcagcgg gtattcttta
     8821 tccatttaca gggatttata ttgatcctct cattgcagca gtcctgatgt caatctcaac
     8881 cgtgattgtc gcaatcaacg cgatgggatt gaggtatgat aaaaaataga agagcacatg
     8941 ctcttctatt tttttcatac taattatgaa acttttatca cttaaatata cttaaagatt
     9001 aactatgata tcacacaaat actaatgatt gtaatgatat ttttaaatat ggtttatttt
     9061 taaatgattt tagaatcttt cgttcataat catttaattg actcccttta tgaactaaaa
     9121 aataaatatt acctctaaga taacgattag catcaaaaac atcaaagact ccttgaagta
     9181 aataatcttt agtatcttga agcagttttt ttatttctaa tttaacctca ttagaatcaa
     9241 gataaatatc tatattttcc ataaacactt gatagctttt tcctctttta atttttctta
     9301 gcttttgttt agtaaggctt tcaaatctaa cgagtccatt tctttcatag tgaacttcat
     9361 tcttctgttc ttcgttccat ctctttccag gatcttgcat ctttttaaga ttatccacaa
     9421 tttgcttagt ttcccttgct ttttcttcac tgcttctttc tttatttgtt ttaggtttat
     9481 tcttatcttt gattaaaaat atatcgtcta aattttctgc ctctttattt tgactcatta
     9541 gttctcttcc tttttgctca gaagtcaata aattggacta tttttattca gttacttagg
     9601 caacatttga gatacgattg cgattataaa aattaatata ccaaccaatg gctgcttgga
     9661 agactgacat attagcctcg atatcatcga ataactaaat acagaaaaat acaataaata
     9721 ttatcggact agggactata ctaggaaaca tcagtacatt ccttaaatca gggtctataa
     9781 ttataggatg actcctaaat ctaaaaagac aaggcccatt aatttattaa ctaataatat
     9841 tgaatttcaa tttcatagga aaactggtaa actattcaac acaatagttg aaaaggtgga
     9901 aagaaaatgt ttgaacaagc agttaactac aaaaatggac tatataaaga actatctaaa
     9961 attggtaagg ggctaagcag tgatcgacga ttagaaattc ttgatctttt aactcaagca
    10021 cccaaatcag ttgaaactat tgccaacggg gtcggaataa gtgtagctaa cgcctcacgc
    10081 catctacaaa tattgaagga cagtcatctg gttaaaacaa aacgaaaagg caatcatatt
    10141 atttatagcc ttagttctcc caaaattagt gattttgtgc acctattaac cgatattggc
    10201 aacagtgaac tttcagatat gaaaacaatt caggataaat cagacgctca agataacgtt
    10261 aaaaccattt ccttaaagca agctcaagaa gaatacaaaa atagctttgt ccttgatgta
    10321 cgaccttctg atgaatatgc agcaggccac atacaatcgg caattaatgt cccattggaa
    10381 acattaaaag aatcaatgcc caaattacct aaagatcaaa aaattattgt ttattgccgt
    10441 ggaagactat gtgctaattc caacattgcc acacagatct taaatagaaa tggttttgac
    10501 gcagttagtt taaattcaag ttactatgat tggaataaaa taacagaata aacagtttaa
    10561 gcacgattta gtcatttatt gattaaatcg tgcttttata ttgacttaca aaaagtatgt
    10621 gatattatta aactattcaa gcaaacaatt gaataattga aaggcggtga cataacttgt
    10681 ctactattga taaaacgcta accttaatta attttgagaa taattggtgc gcccagtgtt
    10741 acacgcagcg accaataata aataagatta gccatgactt taattcatat ttaaacgttc
    10801 gggtagtgaa ttcagatgct cacccagaac cagcaaaaaa atacaatgtt tattccgcac
    10861 ccagtactat tttgctgcgt gatggaaaaa tcgttgaaaa aattacccgt tttattgatc
    10921 aatcacaatt aacaacttta attaaatatt acctataaag gagcgactct tatggttaag
    10981 aacttaactg acaaagactt tgtgaaagaa actagtaccg gtgttacatt aactgatttt
    11041 tgggctactt ggtgtcctcc atgtcgaatg caaggaccga ttattgaaca acttgataaa
    11101 gaaattggcg ataaagtcaa aattactaaa atagacgtag atgcaaatca aaaaacacca
    11161 atagcatttg gaattatgtc tattccaacc ttaattatca aaaaagatgg ccaagtagtt
    11221 gataagctgg ttggcctcca cagtaaggac caacttaaaa ccgttcttgc tcaatatact
    11281 aattaggtta agaggggaga agctgaatgg aacaactatc agtaatgaat aaaaaagaat
    11341 ttgataaaaa actgaagaat ggaaaatata ttttagtttt tatggcttct tggtgccctg
    11401 attgtagctt tatcaagcct catctaccag agattgaaca agaattcaaa gattacactt
    11461 tcatcagtgt cgatcgtgat gagaataccg aattggctca agaactaaat atctttggta
    11521 ttccaagctt cgttattttt agagatgggc aagaaatcgg aagacttgtc aataaagatc
    11581 ggaagactaa agaagaagtc gaaaatttca ttaccaacac tattaactaa tgaagaagtt
    11641 ttttactatt cttggcggta tggggacgtt agcaactgaa agttatgtcc gactccttaa
    11701 taagaaaact gaaacccata aagaccaaga ctatttagat tatatagtgg gtaaccatta
    11761 ttgatgcaca agaagtcatt gttaatcgtt cattggataa gggattagcg ttacgtgacg
    11821 actaataagt agattggagt gaaatttaat gaggaaatat gatgtagtag tgattggggc
    11881 cggtcctggt ggaatgaccg ctgccttata tgcagcacga gctaatttaa atgtagcaat
    11941 gcttgatcgc ggtatttatg gtggacaaat gaacaacacc gatgacattg aaaactaccc
    12001 tggttttaca acaattaagg ggcctgaact tggtgagaaa atgtatcaag gaaccgttaa
    12061 ggccggagta aattttgtat acggtgatgt ccaaaacgtt accgttgatg atcaacaaat
    12121 gaagcatatt caaaccgata gtgacgagtt agtagcaagc gcagtaatta ttgcaacagg
    12181 atctaataat cgaaaattag gtgtaccagg tgaagaaaat ttctccggaa aaggggtttc
    12241 ttactgtgca gtatgtgatg gttctttctt taaaggaaag aacgtgactg tagttggcgg
    12301 tggtgattca gcaatttctg aaggattgta cttagctaat gtcactgatg gagttaatgt
    12361 cattcatcgt cgcgatcagt tacgggcaca aaaggtatta caaaatcgtg cttttgataa
    12421 cgataagata gatttcactt ggaatactag tgtgacagag attttaggtg atgaaaatca
    12481 tgttactgga gtaaaaattc ataacaatca ggtcggtgat gatacaactc tagacactga
    12541 tggagttttc gtttacgtcg gtaactttcc aaacagccaa attttcaata atttaaatat
    12601 taccgatcaa gctggttgga ttataactaa cgatcaaatg gaaacaacaa ttcctggaat
    12661 ctatgcaatt ggtgatgtcc ggcaaaagca actgcggcaa attacaactg cggttggcga
    12721 tggtggtatt gctgggcaaa acgcctttga atatttcgaa gccataaagc atcggcaaac
    12781 ggttaaagat taaagagagg aaaattactt tatggaaatc aaatattggt cagacattgc
    12841 ttgccccttt tgttatatcg gttctaaccg aatgaaacga gcaatgaagg aaattggtat
    12901 ttatgacaca actgaattag agttcaaatc attcgagctt aaccctgcaa caccaaagga
    12961 aaccgatgaa ggatacatta atcacttcac tcagggaaat aaggcaatgg agccacaggc
    13021 caaaaagcaa atggcttaca tcgaacaaat ggcgcataac gatggtctac caatggatct
    13081 tgacagtgta gtacctacaa atactatgga tgcgcaccgg attattaaat tcgcagaagc
    13141 taaaaatgat cctgatttga ctgaacgagt aattagacgc ttctaccaag tttactttag
    13201 tgatggtcaa tcgatttctg accatgatgt gctattaaat gcggcaatgg aagctgggct
    13261 tgctaaagac gaagtagaaa aagtgcttaa ttctaaccaa tatcatcaag ctgtggtcaa
    13321 tgacgaggca gaggctcaac aatccggtat tcatgctgca cctttttttg taatcaataa
    13381 taagtatgca attagtggtg ctcaaccata tgaagtcttt gttaaagcct taaagggcgt
    13441 tcaagcagaa gaaaattagg aggaatttac gatgaccgaa gataagccac aatttaatac
    13501 aatatttggc gataataatg atgctgctgt atgtgggcca gacggttgta atatcgctga
    13561 acatcaaaag caaactgagg ataagaagaa aacaaaataa atggaggaaa gctataaatg
    13621 aagtttgact acgttgttat tggcagtggg ccatcagttt atcgtttcct attgggaatg
    13681 cagaatagcg gaaagaaaat cgcggttgtt gaaaagaatc ggtttggcgg aatttgccct
    13741 aacgaaggct gcgaacccaa gattttctta gaaggagcag cacgagcaac cttaacttca
    13801 atgcgtttgc aaggtaaggg aattactcaa ccagctaagc ttgactggaa agaacttatt
    13861 cagcaaaaga ataaggctat ggcgtcattc ctaaataata tgcaaagtat gtatgaaggc
    13921 ctgggtgcga ctaccatcaa gggtgaagca tcatttgttg atcaacatac cattgaagtt
    13981 aataataaaa aaatcactgc tgataatttt gtaatcgcaa ccggaaaaaa gccgcatcct
    14041 cttaacattc ctggccacga gtacctactt actagtacta acctttttga actcgaagat
    14101 actccaaaga acgtcgcaat tatcggaagt ggttacgttg gtatggaatt tgctacattg
    14161 ttgtctgctg ccggggttaa agtaacagtt attgttcgat ccggccaacc actagaggga
    14221 ttttacagcc aacacgttca tcagttagtt gatgaaatga aaaactcact tggtattaat
    14281 tttatattta acacaaatgt tacagctgtt accgaagcac aaactggcta tgaggttcaa
    14341 tcagctaacg gcaaccttgg cacttttgat aaagttatta atgccagtgg tagagttcct
    14401 gaaattaatg cattgaaact tgataatgct ggtgtagagt acagcaaccg cggaattaaa
    14461 gttgataaat atttgaccac atcagcaaat aacatttacg caatgggcga tattgttgat
    14521 aaaaccgcac cagcattaac ctctacggca cagtttgaag cagactactt aagtgcctta
    14581 cttactaata aaacaactga acctcttagg tacccagtaa ttggaaccgt tacgttcaca
    14641 ttcccccaac tcgctcaagc tggaattagt attgataaag caaaggaaga cagtaattat
    14701 tcaattaaag atattgatat tactcaaggt gactttcttt atgctggaac agatgatcac
    14761 gcacgattat cattagtctt tgacaagcaa aatcatctcg tgggcgctgc tgaaattagc
    14821 caaacagcag tagatgatat caattcacta attcctgtta tggcaattga tgttgatcca
    14881 gaggtttgga aagaaaagat gctaatggct ttccctggtt tagcatataa aattagaaca
    14941 ttaatttaac aacaagaggg tctatttgtg ataataactt cttaaaaatc ctattaaaac
    15001 agcccctaac aaatcaactt gtcttgttag aggctgtttt ttatttaaat aatataatag
    15061 cccttggaat gcaaggctaa atcgaatagc taatcattac tatatagagg cgtaatcatt
    15121 actatataga ggcgcataca tactttgttt ctcaattttg gctaggtatg ttataatgaa
    15181 tgcagaaaaa ggaagccttg cgctaacaag acttcccgtg tagagccgta taagacggtg
    15241 gcattaatta acgattgaac ataaccgcta gcttgccaga gctaaggcgg ttattttttt
    15301 tgctgatttt taataaactc aacaactaat gctagtaagg cgactataaa agtgccaaac
    15361 atgaacataa gctgtaaagc gtccgatacg gacacttggg ctactccttt cctagaatgt
    15421 gagtttatag tttttacacc ataagcacca ccccctttaa ggaaatagcc accgccttaa
    15481 cttctctact caaactatta tacaggataa cgtataattt acctattgat gattaatgct
    15541 cttatatcct gaattgctat gtttctattt tcaatataaa tataattatc agacatgttt
    15601 tcaatgaacc tagatatatt tttttggttt catgattgaa gttagtctca tctaattgaa
    15661 tagtcgcagt ataataattg gcaatgaaaa atgtaataaa aaagaatata ttaaccattt
    15721 tttatttcaa atcgtcaaat ttaatttcgc cttttttcag actatttaat ccatgatgag
    15781 taattgtgtt gattaaagga ccccatgcat tcgtggtagc tttaggatcc ttatttaagg
    15841 ataatcgttt catctgttgc tcataatatg ctagacccac catgccccaa tttattatcg
    15901 ataactttta caccagttgt taaatgtggt aattttagac cctcaaaaat tccagacagc
    15961 attttctcag gggaattcgg attgagaaca aatggtcgta cactccccac catggcaatt
    16021 ccttcgtttg tcactacatt ttccatggct tcttggctgc tcaaaccgcc tgtaagcata
    16081 atagggatat tgactgatac ttgagatttt ttagaaaact ttaaaaagaa cgcttctcca
    16141 ttactatttt caagaaactt ggttctttca taatttcctc ctgaaatttt aataaagtca
    16201 atacctaaat tagacatttt gacgattact ctatatgaat catcttcact aaatccttcc
    16261 gaactgaagt cactggaatt cagtttgatc ccaacaataa aattagattt agttacttgg
    16321 cgaatacctt gatatatttc aaccaaaatt cgcattatat tttctaaatt atctccataa
    16381 aaatctgttc gcttattatc tgctggagag agaaactggt ttttcagcga tacaacttgt
    16441 tgtcacaaat ttttgaataa cattaaccac ctgttttaga caattcgcga ggagtattaa
    16501 ataatttacg tagattctta ggcattggaa tcacacttgg cgcaaccggt tctttcgtca
    16561 tagaacgtgg agtatgttta ccagaatggt taatttgcag aataaatttt gtattatttt
    16621 cagtgccagc ttgtgcccat ttttttgtct gtttgttgat ccaccactac attacttggt
    16681 tcaccaatat tttacgctcc cggatttagt gtagagactt aagttatttc aataactaat
    16741 taagaaaatt atttaattca tcgacaaact cctcagcata ttggaagatg gcgccgtgac
    16801 cagcatcagg atagatgatg agtttgctat cctggatttt ctcgtgcatg tcgtaggagt
    16861 tctgcgttgg aaccataaca tcgttgtctc cgttgacaat gaatgtcgga actttgataa
    16921 aatcaagcgt gtcctgctct gcctttcccc aactcttgat agctttcaac tgcttcaaga
    16981 aactggatac tttcatatcc ttgtccttgg catctttcgg acggctagcc aatctatcta
    17041 aaactttgtg cgcttcgact tttcctgcct tgtcaggatt atagaaaata taacgtttgg
    17101 catccgcacc gtgtaaaaag ccatttgcca tgtgtttgaa ggtcacacca gtcaccttat
    17161 caacaccgat acccgcacgt ggaccagttc cagctaaagt caaggtattg acaagattgg
    17221 catcaagtct gacaatttct tgggcgataa agccgcccat ggaaagacca aggagattga
    17281 ttttttggta acccagcgcc ttgataatag caatggcttg gtctgccatg caaggaatgc
    17341 tttccgcaat tttcccctca ctggcaccaa cacctggcaa atccatgaca atgatgtggt
    17401 tcttttctgc taggttatca atgagttttg gatcccaatt gtccatggtc gctgccaaat
    17461 gcaccaacat gacaagcgga tattgtgact taccttgtcc aagttcacgg taggcgattt
    17521 tcaagccttc gacggtgatg tattgatttt tcgtttgtaa gtatgacatt ttatttttct
    17581 ccgaaggtga taacggtctt accacgtgaa cgtccatttg cgaccttgtc taaggcctcg
    17641 ttaatctgtg agaagttata aacggtatca attgatggtt tgatttttag ttggctaaag
    17701 aggtctgcaa cttcttgaag ctgggcaccg tttgattcaa cgaagacgaa atcataagta
    17761 accccatatt tcttagccat tctatcgaat ttaccaccca caagaccgaa caagatttgt
    17821 ttccacttag gtagtccgaa gcgtttggca aaggctttat ttggcatgcc acttaggttg
    17881 acgagtttac cgcctttttt cataatgctc atttgttttt cagtctcagc accgcccaat
    17941 gtatccaaaa cataatccac ctggctgagt gtttgcgtgt aatcctcagt tttgtagtcg
    18001 ataaaacggt tcagccccag cgccataata cgcgctttat tgtcaatatt cccgttggtg
    18061 atgacggtca gccccttagc ttttgcgata ggaatcgcca tggcaccgac accacctgta
    18121 ccacccgtca taaagaaggt accgcccttt ttcgcgccca tcaggtcaag cgcctgcata
    18181 accgtaagag cagtcaaggg caccgctgct gcctcaacat ccgttagata atctgggaca
    18241 tgggctagcg ctcgataatt aatcgccgta tactcggcaa atgcaccgat acggtcaagc
    18301 ggcatgcgtg caaagacacg gtcaccaact ttaaatcctg tcacttgcgt gcctactttt
    18361 tctacaatcc caacgacttc attaccagca atttgtggga gtttgtaggg aatgaggagc
    18421 ttgatttgtc ctcgtgaaat catgttatca actggattga ctcctgcggc tgtgactttg
    18481 acaaggacat cttgagcgcc aagttcaggc atcggtgtgt caacgagttc aagtttgata
    18541 ttgtttttat tatattgggt taattgtgct gctttcatgg agatttcctt ttcttaattg
    18601 attttataca tatcagtgat taaatctgac aaattttctt ggttgaggcg attgagaagg
    18661 ctggcttctg cgtcttcaaa gactgggctg agcacctgtt cgatacgact accgactgga
    18721 cagttgggat tggcatcttc gtggacgtgg agcagagttt tttctggata gactgcttgg
    18781 tagacttctt ttaaggaaat atcagcgggt tcttttacta ggtaaaaacc agacttccct
    18841 tgttggctag caatcagacc tgcttgcttt agcaagagag tgatctttcg gatatgactg
    18901 gcattggtgt tgactgactg agctagattt tctgatgatg gtgtcttttc tgtttcagaa
    18961 atgtatatta aaatgtgtag cgctactgaa aa
//
