locus-tag	class	description
HRE53_RS00010	COG3335	DDE superfamily endonuclease
HRE53_RS00095	COG0517	IMP dehydrogenase activity
HRE53_RS00095	COG0516	GMP reductase activity
HRE53_RS00105	COG0616	signal peptide processing
HRE53_RS00110	COG0697	spore germination
HRE53_RS00115	COG2233	PERMEase
HRE53_RS00130	COG5002	protein histidine kinase activity
HRE53_RS00140	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HRE53_RS00175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRE53_RS00175	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HRE53_RS00190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRE53_RS00220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRE53_RS00230	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRE53_RS00245	COG3659	wide pore channel activity
HRE53_RS00255	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_RS00260	COG0802	atpase or kinase
HRE53_RS00320	COG1217	gtp-binding protein TYPA
HRE53_RS00325	COG0784	Response regulator, receiver
HRE53_RS00325	COG5002	protein histidine kinase activity
HRE53_RS00330	COG5001	Diguanylate cyclase
HRE53_RS00330	COG4251	negative regulation of phosphorylation
HRE53_RS00330	COG3706	GGDEF domain
HRE53_RS00330	COG2203	Gaf domain
HRE53_RS00335	COG0432	Pfam Uncharacterised protein family UPF0047
HRE53_RS00340	COG1840	ABC-type Fe3 transport system, periplasmic component
HRE53_RS00345	COG1196	nuclear chromosome segregation
HRE53_RS00345	COG3264	Mechanosensitive ion channel
HRE53_RS00360	COG0598	Magnesium transport protein CorA
HRE53_RS00375	COG0457	Tetratricopeptide repeat
HRE53_RS00375	COG0705	Rhomboid family
HRE53_RS00385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRE53_RS00425	COG3536	Protein conserved in bacteria
HRE53_RS00430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HRE53_RS00445	COG0315	cyclic pyranopterin monophosphate synthase activity
HRE53_RS00470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HRE53_RS00480	COG1595	DNA-templated transcription, initiation
HRE53_RS00500	COG0513	Belongs to the DEAD box helicase family
HRE53_RS00505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_RS00510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_RS00515	COG1260	myo-inositol-1-phosphate synthase
HRE53_RS00530	COG0837	glucose binding
HRE53_RS00535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRE53_RS00540	COG0366	Alpha amylase catalytic
HRE53_RS00545	COG3291	Pkd domain containing protein
HRE53_RS00545	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HRE53_RS00565	COG0672	)-iron permease
HRE53_RS00610	COG0436	Aminotransferase
HRE53_RS00615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_RS00630	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRE53_RS00640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HRE53_RS00655	COG2226	methyltransferase
HRE53_RS00680	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HRE53_RS00700	COG0072	phenylalanine-tRNA ligase activity
HRE53_RS00790	COG4251	negative regulation of phosphorylation
HRE53_RS00795	COG0784	Response regulator, receiver
HRE53_RS00800	COG2204	response regulator
HRE53_RS00805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HRE53_RS00810	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HRE53_RS00850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRE53_RS00880	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HRE53_RS00900	COG3608	succinylglutamate desuccinylase aspartoacylase
HRE53_RS00900	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HRE53_RS00915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRE53_RS00950	COG1943	Transposase
HRE53_RS00965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRE53_RS00970	COG0573	inorganic phosphate transmembrane transporter activity
HRE53_RS00975	COG0581	inorganic phosphate transmembrane transporter activity
HRE53_RS00980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRE53_RS00990	COG3903	Transcriptional regulator
HRE53_RS00990	COG2319	Wd-40 repeat
HRE53_RS01000	COG3328	transposase activity
HRE53_RS01020	COG0175	sulfate reduction
HRE53_RS01045	COG5285	phytanoyl-CoA dioxygenase
HRE53_RS01055	COG0534	Mate efflux family protein
HRE53_RS01070	COG5433	transposase activity
HRE53_RS01085	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS01115	COG1132	(ABC) transporter
HRE53_RS01125	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HRE53_RS01145	COG0489	protein tyrosine kinase activity
HRE53_RS01160	COG0745	RESPONSE REGULATOR receiver
HRE53_RS01170	COG5002	protein histidine kinase activity
HRE53_RS01200	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HRE53_RS01220	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HRE53_RS01225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HRE53_RS01235	COG0019	diaminopimelate decarboxylase activity
HRE53_RS01240	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HRE53_RS01255	COG0484	heat shock protein binding
HRE53_RS01260	COG1459	type II secretion system
HRE53_RS01270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRE53_RS01275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRE53_RS01280	COG0443	Heat shock 70 kDa protein
HRE53_RS01285	COG0484	heat shock protein binding
HRE53_RS01295	COG1162	GTPase activity
HRE53_RS01315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRE53_RS01320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRE53_RS01350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRE53_RS01370	COG0515	serine threonine protein kinase
HRE53_RS01400	COG0022	dehydrogenase e1 component
HRE53_RS01400	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRE53_RS01405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRE53_RS01410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HRE53_RS01465	COG4636	protein conserved in cyanobacteria
HRE53_RS01470	COG2827	Endonuclease containing a URI domain
HRE53_RS01495	COG0390	transport system, permease component
HRE53_RS01505	COG1994	Peptidase M50
HRE53_RS01510	COG0484	heat shock protein binding
HRE53_RS01525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRE53_RS01530	COG0515	serine threonine protein kinase
HRE53_RS01530	COG3266	domain, Protein
HRE53_RS01555	COG0517	IMP dehydrogenase activity
HRE53_RS01555	COG1125	glycine betaine transport
HRE53_RS01560	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_RS01565	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_RS01575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRE53_RS01580	COG0416	fatty acid biosynthetic process
HRE53_RS01590	COG4399	Belongs to the UPF0754 family
HRE53_RS01595	COG1131	(ABC) transporter
HRE53_RS01600	COG0631	protein serine/threonine phosphatase activity
HRE53_RS01605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRE53_RS01610	COG3937	granule-associated protein
HRE53_RS01615	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRE53_RS01630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRE53_RS01630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRE53_RS01640	COG0577	efflux transmembrane transporter activity
HRE53_RS01645	COG0577	efflux transmembrane transporter activity
HRE53_RS01660	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HRE53_RS01680	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HRE53_RS01680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRE53_RS01705	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HRE53_RS01710	COG1216	Glycosyl transferase, family 2
HRE53_RS01710	COG0463	Glycosyl transferase, family 2
HRE53_RS01715	COG2244	polysaccharide biosynthetic process
HRE53_RS01765	COG1429	ligase activity, forming nitrogen-metal bonds
HRE53_RS01775	COG1022	Amp-dependent synthetase and ligase
HRE53_RS01790	COG0482	sulfurtransferase activity
HRE53_RS01795	COG0724	RNA recognition motif
HRE53_RS01800	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRE53_RS01805	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRE53_RS01820	COG0793	Belongs to the peptidase S41A family
HRE53_RS01830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRE53_RS01840	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS01845	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS01855	COG0297	glycogen (starch) synthase activity
HRE53_RS01870	COG1234	tRNA 3'-trailer cleavage
HRE53_RS01895	COG5002	protein histidine kinase activity
HRE53_RS01930	COG0556	nucleotide-excision repair
HRE53_RS01935	COG2205	protein histidine kinase activity
HRE53_RS01945	COG2048	Heterodisulfide reductase, subunit B
HRE53_RS01955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRE53_RS01960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRE53_RS01965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRE53_RS01980	COG0346	lactoylglutathione lyase activity
HRE53_RS02005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRE53_RS02015	COG0193	aminoacyl-tRNA hydrolase activity
HRE53_RS02020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRE53_RS02040	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HRE53_RS02050	COG0233	cytoplasmic translational termination
HRE53_RS02055	COG0528	UMP kinase activity
HRE53_RS02070	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRE53_RS02115	COG0668	transmembrane transport
HRE53_RS02140	COG1136	(ABC) transporter
HRE53_RS02140	COG0577	efflux transmembrane transporter activity
HRE53_RS02145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRE53_RS02155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_RS02165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRE53_RS02185	COG2205	protein histidine kinase activity
HRE53_RS02205	COG2217	Heavy metal translocating P-type atpase
HRE53_RS02235	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HRE53_RS02240	COG0469	pyruvate kinase activity
HRE53_RS02245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRE53_RS02250	COG0625	glutathione transferase activity
HRE53_RS02265	COG0038	chloride channel
HRE53_RS02285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRE53_RS02295	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRE53_RS02330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRE53_RS02335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRE53_RS02335	COG3266	domain, Protein
HRE53_RS02340	COG0195	Participates in both transcription termination and antitermination
HRE53_RS02345	COG0779	Required for maturation of 30S ribosomal subunits
HRE53_RS02360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRE53_RS02365	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HRE53_RS02405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HRE53_RS02410	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HRE53_RS02420	COG0004	ammonium transporteR
HRE53_RS02435	COG0784	Response regulator, receiver
HRE53_RS02435	COG0643	Histidine kinase
HRE53_RS02435	COG2198	Histidine kinase
HRE53_RS02440	COG0840	transmembrane signaling receptor activity
HRE53_RS02440	COG2203	Gaf domain
HRE53_RS02455	COG0784	Response regulator, receiver
HRE53_RS02465	COG0066	3-isopropylmalate dehydratase activity
HRE53_RS02480	COG4636	protein conserved in cyanobacteria
HRE53_RS02485	COG0473	3-isopropylmalate dehydrogenase activity
HRE53_RS02495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRE53_RS02500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRE53_RS02505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRE53_RS02510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRE53_RS02515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRE53_RS02525	COG0356	it plays a direct role in the translocation of protons across the membrane
HRE53_RS02550	COG2226	methyltransferase
HRE53_RS02575	COG0175	sulfate reduction
HRE53_RS02580	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HRE53_RS02595	COG0830	nickel cation binding
HRE53_RS02600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRE53_RS02605	COG3659	wide pore channel activity
HRE53_RS02615	COG0559	Belongs to the binding-protein-dependent transport system permease family
HRE53_RS02635	COG0625	glutathione transferase activity
HRE53_RS02640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRE53_RS02645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRE53_RS02670	COG5398	heme oxygenase
HRE53_RS02675	COG1970	mechanosensitive ion channel activity
HRE53_RS02680	COG0275	rRNA processing
HRE53_RS02690	COG0768	penicillin binding
HRE53_RS02695	COG3011	Protein conserved in bacteria
HRE53_RS02705	COG0612	Peptidase, M16
HRE53_RS02725	COG1233	COG1233 Phytoene dehydrogenase and related
HRE53_RS02740	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HRE53_RS02740	COG1672	PFAM Archaeal ATPase
HRE53_RS02750	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HRE53_RS02760	COG0745	RESPONSE REGULATOR receiver
HRE53_RS02770	COG0484	heat shock protein binding
HRE53_RS02775	COG2124	cytochrome p450
HRE53_RS02785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRE53_RS02795	COG1309	transcriptional regulator
HRE53_RS02800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_RS02805	COG1122	ATPase activity
HRE53_RS02815	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRE53_RS02820	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HRE53_RS02840	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS02855	COG0431	NADPH-dependent FMN reductase
HRE53_RS02870	COG0745	RESPONSE REGULATOR receiver
HRE53_RS02880	COG0646	methionine synthase
HRE53_RS02880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HRE53_RS02885	COG1615	UPF0182 protein
HRE53_RS02915	COG1515	deoxyribonuclease V activity
HRE53_RS02920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRE53_RS02945	COG1361	Conserved repeat domain
HRE53_RS02980	COG0300	oxidoreductase activity
HRE53_RS02990	COG0156	8-amino-7-oxononanoate synthase activity
HRE53_RS02995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRE53_RS02995	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_RS02995	COG3321	synthase
HRE53_RS02995	COG4221	oxidoreductase activity
HRE53_RS03020	COG0318	PFAM AMP-dependent synthetase and ligase
HRE53_RS03035	COG0534	Mate efflux family protein
HRE53_RS03050	COG2258	MOSC domain
HRE53_RS03095	COG4149	molybdate abc transporter
HRE53_RS03100	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRE53_RS03115	COG2363	Small membrane protein
HRE53_RS03125	COG0724	RNA recognition motif
HRE53_RS03135	COG5002	protein histidine kinase activity
HRE53_RS03135	COG0784	Response regulator, receiver
HRE53_RS03135	COG2205	protein histidine kinase activity
HRE53_RS03185	COG0564	pseudouridine synthase activity
HRE53_RS03290	COG0814	amino acid
HRE53_RS03295	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRE53_RS03305	COG0587	DNA-directed DNA polymerase activity
HRE53_RS03330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRE53_RS03335	COG2226	methyltransferase
HRE53_RS03345	COG1446	asparaginase
HRE53_RS03365	COG2095	MarC family integral membrane protein
HRE53_RS03400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRE53_RS03410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRE53_RS03425	COG1054	Belongs to the UPF0176 family
HRE53_RS03435	COG3239	Fatty acid desaturase
HRE53_RS03450	COG0277	FAD linked oxidase domain protein
HRE53_RS03455	COG1799	cell septum assembly
HRE53_RS03460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HRE53_RS03480	COG1968	undecaprenyl-diphosphatase activity
HRE53_RS03490	COG0024	Methionine aminopeptidase
HRE53_RS03505	COG0424	maF-like protein
HRE53_RS03565	COG0495	leucyl-tRNA aminoacylation
HRE53_RS03615	COG1216	Glycosyl transferase, family 2
HRE53_RS03650	COG0515	serine threonine protein kinase
HRE53_RS03650	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS03655	COG0640	Transcriptional regulator
HRE53_RS03665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HRE53_RS03680	COG1126	abc transporter atp-binding protein
HRE53_RS03685	COG0765	amino acid transport
HRE53_RS03690	COG4597	amino acid ABC transporter
HRE53_RS03695	COG0517	IMP dehydrogenase activity
HRE53_RS03695	COG0617	tRNA 3'-terminal CCA addition
HRE53_RS03695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HRE53_RS03705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HRE53_RS03715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRE53_RS03735	COG1045	serine acetyltransferase
HRE53_RS03750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRE53_RS03765	COG4251	negative regulation of phosphorylation
HRE53_RS03775	COG0463	Glycosyl transferase, family 2
HRE53_RS03775	COG0457	Tetratricopeptide repeat
HRE53_RS03800	COG1136	(ABC) transporter
HRE53_RS03835	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HRE53_RS03835	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HRE53_RS03840	COG4372	Transposase
HRE53_RS03855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRE53_RS03870	COG1191	sigma factor activity
HRE53_RS03880	COG0657	acetylesterase activity
HRE53_RS03910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRE53_RS03915	COG4585	Histidine kinase
HRE53_RS03920	COG2197	response regulator
HRE53_RS03945	COG0681	Belongs to the peptidase S26 family
HRE53_RS03965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRE53_RS03970	COG3706	GGDEF domain
HRE53_RS03970	COG4251	negative regulation of phosphorylation
HRE53_RS03970	COG2203	Gaf domain
HRE53_RS03970	COG5001	Diguanylate cyclase
HRE53_RS03985	COG3457	Alanine racemase
HRE53_RS03995	COG0724	RNA recognition motif
HRE53_RS04000	COG0724	RNA recognition motif
HRE53_RS04005	COG0542	response to heat
HRE53_RS04035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HRE53_RS04060	COG1192	Involved in chromosome partitioning
HRE53_RS04065	COG0583	DNA-binding transcription factor activity
HRE53_RS04080	COG0501	Belongs to the peptidase M48B family
HRE53_RS04090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRE53_RS04100	COG3706	GGDEF domain
HRE53_RS04100	COG2203	Gaf domain
HRE53_RS04100	COG4251	negative regulation of phosphorylation
HRE53_RS04100	COG5001	Diguanylate cyclase
HRE53_RS04130	COG3541	Predicted nucleotidyltransferase
HRE53_RS04145	COG0840	transmembrane signaling receptor activity
HRE53_RS04165	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HRE53_RS04175	COG1575	Belongs to the MenA family. Type 1 subfamily
HRE53_RS04180	COG0484	heat shock protein binding
HRE53_RS04185	COG0702	epimerase
HRE53_RS04190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRE53_RS04200	COG0322	excinuclease ABC activity
HRE53_RS04205	COG0297	glycogen (starch) synthase activity
HRE53_RS04215	COG1309	transcriptional regulator
HRE53_RS04225	COG1649	PFAM Uncharacterised BCR, COG1649
HRE53_RS04240	COG3328	transposase activity
HRE53_RS04255	COG0735	belongs to the Fur family
HRE53_RS04295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRE53_RS04305	COG1420	regulation of RNA biosynthetic process
HRE53_RS04325	COG0582	viral genome integration into host DNA
HRE53_RS04335	COG0582	viral genome integration into host DNA
HRE53_RS04375	COG0776	regulation of translation
HRE53_RS04380	COG0575	Belongs to the CDS family
HRE53_RS04390	COG0745	RESPONSE REGULATOR receiver
HRE53_RS04400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HRE53_RS04405	COG1051	belongs to the nudix hydrolase family
HRE53_RS04410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRE53_RS04425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRE53_RS04460	COG1331	Highly conserved protein containing a thioredoxin domain
HRE53_RS04485	COG1671	Belongs to the UPF0178 family
HRE53_RS04505	COG0625	glutathione transferase activity
HRE53_RS04520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_RS04520	COG2205	protein histidine kinase activity
HRE53_RS04525	COG2205	protein histidine kinase activity
HRE53_RS04525	COG0784	Response regulator, receiver
HRE53_RS04525	COG2198	Histidine kinase
HRE53_RS04540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRE53_RS04585	COG0523	cobalamin synthesis protein
HRE53_RS04630	COG2319	Wd-40 repeat
HRE53_RS04630	COG5635	Nacht domain
HRE53_RS04645	COG1252	NADH dehydrogenase
HRE53_RS04655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRE53_RS04690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRE53_RS04695	COG0719	Fe-S assembly protein
HRE53_RS04700	COG0396	ATPase activity
HRE53_RS04705	COG0719	Fe-S assembly protein
HRE53_RS04735	COG1309	transcriptional regulator
HRE53_RS04770	COG3328	transposase activity
HRE53_RS04775	COG0300	oxidoreductase activity
HRE53_RS04780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HRE53_RS04785	COG1376	ErfK ybiS ycfS ynhG family protein
HRE53_RS04790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRE53_RS04795	COG0254	rRNA binding
HRE53_RS04800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRE53_RS04805	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRE53_RS04810	COG0101	tRNA pseudouridine synthase activity
HRE53_RS04815	COG0203	ribosomal protein L17
HRE53_RS04820	COG0202	RNA polymerase activity
HRE53_RS04825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRE53_RS04830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRE53_RS04835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRE53_RS04840	COG1410	methionine synthase
HRE53_RS04840	COG0646	methionine synthase
HRE53_RS04880	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HRE53_RS04895	COG2827	Endonuclease containing a URI domain
HRE53_RS04950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRE53_RS04955	COG2264	protein methyltransferase activity
HRE53_RS04995	COG2911	Protein conserved in bacteria
HRE53_RS04995	COG1361	Conserved repeat domain
HRE53_RS04995	COG3266	domain, Protein
HRE53_RS05000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRE53_RS05005	COG4956	integral membrane protein (PIN domain superfamily)
HRE53_RS05015	COG0159	tryptophan synthase activity
HRE53_RS05030	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRE53_RS05040	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HRE53_RS05060	COG4584	PFAM Integrase catalytic
HRE53_RS05065	COG1484	DNA-dependent DNA replication
HRE53_RS05085	COG0606	chelatase, subunit chli
HRE53_RS05090	COG3063	Type IV pilus biogenesis stability protein PilW
HRE53_RS05095	COG4172	Belongs to the ABC transporter superfamily
HRE53_RS05100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_RS05110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRE53_RS05140	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_RS05145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HRE53_RS05150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRE53_RS05155	COG0339	signal peptide processing
HRE53_RS05160	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS05160	COG0515	serine threonine protein kinase
HRE53_RS05165	COG2203	Gaf domain
HRE53_RS05165	COG0840	transmembrane signaling receptor activity
HRE53_RS05170	COG2205	protein histidine kinase activity
HRE53_RS05170	COG0784	Response regulator, receiver
HRE53_RS05180	COG0303	'Molybdopterin
HRE53_RS05190	COG0426	domain, Protein
HRE53_RS05190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRE53_RS05200	COG0426	domain, Protein
HRE53_RS05200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRE53_RS05215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HRE53_RS05235	COG0114	fumarate hydratase activity
HRE53_RS05260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HRE53_RS05265	COG3264	Mechanosensitive ion channel
HRE53_RS05265	COG1196	nuclear chromosome segregation
HRE53_RS05275	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRE53_RS05280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRE53_RS05300	COG1473	amidohydrolase
HRE53_RS05330	COG2308	Evidence 4 Homologs of previously reported genes of
HRE53_RS05335	COG5001	Diguanylate cyclase
HRE53_RS05335	COG5002	protein histidine kinase activity
HRE53_RS05340	COG0709	Synthesizes selenophosphate from selenide and ATP
HRE53_RS05380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HRE53_RS05385	COG2319	Wd-40 repeat
HRE53_RS05385	COG3903	Transcriptional regulator
HRE53_RS05390	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HRE53_RS05395	COG0546	phosphoglycolate phosphatase activity
HRE53_RS05410	COG0512	Glutamine amidotransferase of anthranilate synthase
HRE53_RS05415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HRE53_RS05420	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRE53_RS05430	COG0047	phosphoribosylformylglycinamidine synthase activity
HRE53_RS05435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRE53_RS05440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRE53_RS05450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRE53_RS05450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRE53_RS05465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRE53_RS05480	COG1278	Cold shock
HRE53_RS05485	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HRE53_RS05490	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HRE53_RS05500	COG0489	protein tyrosine kinase activity
HRE53_RS05505	COG0772	Belongs to the SEDS family
HRE53_RS05525	COG0539	negative regulation of cytoplasmic translation
HRE53_RS05530	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HRE53_RS05545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRE53_RS05565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRE53_RS05585	COG0071	Belongs to the small heat shock protein (HSP20) family
HRE53_RS05605	COG2161	toxin-antitoxin pair type II binding
HRE53_RS05610	COG4115	mRNA cleavage
HRE53_RS05615	COG1233	COG1233 Phytoene dehydrogenase and related
HRE53_RS05635	COG0745	RESPONSE REGULATOR receiver
HRE53_RS05665	COG0762	integral membrane protein
HRE53_RS05670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRE53_RS05685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRE53_RS05695	COG0174	glutamine synthetase
HRE53_RS05705	COG5002	protein histidine kinase activity
HRE53_RS05705	COG0784	Response regulator, receiver
HRE53_RS05730	COG2239	Acts as a magnesium transporter
HRE53_RS05740	COG0191	fructose-bisphosphate aldolase activity
HRE53_RS05745	COG0739	heme binding
HRE53_RS05750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HRE53_RS05755	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HRE53_RS05765	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRE53_RS05835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRE53_RS05840	COG1063	alcohol dehydrogenase
HRE53_RS05855	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HRE53_RS05865	COG0509	glycine decarboxylation via glycine cleavage system
HRE53_RS05870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRE53_RS05920	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HRE53_RS05925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRE53_RS05965	COG1733	regulation of RNA biosynthetic process
HRE53_RS05970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_RS05980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRE53_RS05985	COG1121	(ABC) transporter
HRE53_RS05990	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRE53_RS06000	COG2198	Histidine kinase
HRE53_RS06000	COG2205	protein histidine kinase activity
HRE53_RS06000	COG0784	Response regulator, receiver
HRE53_RS06030	COG2226	methyltransferase
HRE53_RS06050	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HRE53_RS06070	COG3328	transposase activity
HRE53_RS06075	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS06075	COG0515	serine threonine protein kinase
HRE53_RS06080	COG1216	Glycosyl transferase, family 2
HRE53_RS06130	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS06130	COG0515	serine threonine protein kinase
HRE53_RS06135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRE53_RS06155	COG1136	(ABC) transporter
HRE53_RS06185	COG0583	DNA-binding transcription factor activity
HRE53_RS06190	COG0604	alcohol dehydrogenase
HRE53_RS06195	COG1024	Enoyl-CoA hydratase
HRE53_RS06195	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRE53_RS06200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRE53_RS06205	COG4221	oxidoreductase activity
HRE53_RS06225	COG2203	Gaf domain
HRE53_RS06225	COG3706	GGDEF domain
HRE53_RS06225	COG4251	negative regulation of phosphorylation
HRE53_RS06225	COG5001	Diguanylate cyclase
HRE53_RS06230	COG1049	propionate catabolic process, 2-methylcitrate cycle
HRE53_RS06235	COG1049	propionate catabolic process, 2-methylcitrate cycle
HRE53_RS06255	COG0135	phosphoribosylanthranilate isomerase activity
HRE53_RS06260	COG0167	dihydroorotate dehydrogenase activity
HRE53_RS06275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HRE53_RS06285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRE53_RS06285	COG0574	Belongs to the PEP-utilizing enzyme family
HRE53_RS06290	COG0589	response to stress
HRE53_RS06315	COG1305	Transglutaminase-like
HRE53_RS06335	COG3854	ATPases associated with a variety of cellular activities
HRE53_RS06345	COG5002	protein histidine kinase activity
HRE53_RS06350	COG5002	protein histidine kinase activity
HRE53_RS06390	COG2072	flavoprotein involved in K transport
HRE53_RS06410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_RS06415	COG2340	Cysteine-rich secretory protein family
HRE53_RS06425	COG0070	glutamate synthase
HRE53_RS06425	COG0067	glutamate synthase
HRE53_RS06425	COG0069	glutamate synthase activity
HRE53_RS06430	COG0784	Response regulator, receiver
HRE53_RS06430	COG2198	Histidine kinase
HRE53_RS06430	COG5002	protein histidine kinase activity
HRE53_RS06435	COG3437	response regulator, receiver
HRE53_RS06445	COG0121	glutamine amidotransferase
HRE53_RS06460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRE53_RS06465	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRE53_RS06480	COG0454	-acetyltransferase
HRE53_RS06500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRE53_RS06505	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HRE53_RS06515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRE53_RS06530	COG1032	radical SAM domain protein
HRE53_RS06550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRE53_RS06555	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRE53_RS06570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRE53_RS06575	COG0513	Belongs to the DEAD box helicase family
HRE53_RS06580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRE53_RS06585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HRE53_RS06590	COG1530	ribonuclease E activity
HRE53_RS06595	COG0412	Dienelactone hydrolase
HRE53_RS06600	COG1725	Transcriptional regulator
HRE53_RS06605	COG2304	oxidoreductase activity
HRE53_RS06625	COG0612	Peptidase, M16
HRE53_RS06645	COG0571	ribonuclease III activity
HRE53_RS06650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRE53_RS06655	COG0484	heat shock protein binding
HRE53_RS06660	COG0037	tRNA processing
HRE53_RS06690	COG0784	Response regulator, receiver
HRE53_RS06695	COG4251	negative regulation of phosphorylation
HRE53_RS06700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRE53_RS06720	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRE53_RS06730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HRE53_RS06740	COG0180	Tryptophanyl-tRNA synthetase
HRE53_RS06745	COG5002	protein histidine kinase activity
HRE53_RS06760	COG0285	dihydrofolate synthase activity
HRE53_RS06790	COG1132	(ABC) transporter
HRE53_RS06795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRE53_RS06800	COG2010	Cytochrome c
HRE53_RS06820	COG1819	glycosyl
HRE53_RS06835	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HRE53_RS06840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRE53_RS06865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRE53_RS06900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRE53_RS06905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRE53_RS06925	COG0243	molybdopterin cofactor binding
HRE53_RS06950	COG4451	ribulose bisphosphate carboxylase, small
HRE53_RS06960	COG1850	ribulose-bisphosphate carboxylase activity
HRE53_RS06970	COG0454	-acetyltransferase
HRE53_RS06985	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRE53_RS07005	COG0051	transcription antitermination factor activity, RNA binding
HRE53_RS07010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRE53_RS07015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRE53_RS07020	COG0049	tRNA binding
HRE53_RS07025	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRE53_RS07030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRE53_RS07035	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRE53_RS07040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRE53_RS07070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRE53_RS07075	COG0745	RESPONSE REGULATOR receiver
HRE53_RS07085	COG1333	cytochrome c biogenesis protein
HRE53_RS07095	COG0772	Belongs to the SEDS family
HRE53_RS07110	COG3659	wide pore channel activity
HRE53_RS07130	COG0783	Belongs to the Dps family
HRE53_RS07135	COG1136	(ABC) transporter
HRE53_RS07175	COG0659	secondary active sulfate transmembrane transporter activity
HRE53_RS07180	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS07185	COG2217	Heavy metal translocating P-type atpase
HRE53_RS07205	COG2321	neutral zinc metallopeptidase
HRE53_RS07235	COG3706	GGDEF domain
HRE53_RS07245	COG1174	glycine betaine transport
HRE53_RS07260	COG0217	transcriptional regulatory protein
HRE53_RS07270	COG2884	Cell division ATP-binding protein ftsE
HRE53_RS07275	COG2177	Part of the ABC transporter FtsEX involved in
HRE53_RS07295	COG0515	serine threonine protein kinase
HRE53_RS07330	COG1666	GTP binding
HRE53_RS07335	COG1012	belongs to the aldehyde dehydrogenase family
HRE53_RS07355	COG0516	GMP reductase activity
HRE53_RS07360	COG3118	belongs to the thioredoxin family
HRE53_RS07390	COG0693	protein deglycase activity
HRE53_RS07425	COG0436	Aminotransferase
HRE53_RS07440	COG0540	Belongs to the ATCase OTCase family
HRE53_RS07450	COG1122	ATPase activity
HRE53_RS07475	COG3594	Acyltransferase
HRE53_RS07485	COG2226	methyltransferase
HRE53_RS07495	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS07500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRE53_RS07500	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS07505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRE53_RS07545	COG2244	polysaccharide biosynthetic process
HRE53_RS07555	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS07580	COG0367	asparagine synthase
HRE53_RS07585	COG2850	peptidyl-arginine hydroxylation
HRE53_RS07590	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HRE53_RS07615	COG1473	amidohydrolase
HRE53_RS07625	COG1397	ADP-ribosylglycohydrolase
HRE53_RS07635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRE53_RS07640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRE53_RS07660	COG0360	Binds together with S18 to 16S ribosomal RNA
HRE53_RS07665	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HRE53_RS07685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRE53_RS07710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRE53_RS07715	COG0488	(ABC) transporter
HRE53_RS07725	COG0454	-acetyltransferase
HRE53_RS07725	COG0456	acetyltransferase
HRE53_RS07730	COG0542	response to heat
HRE53_RS07745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRE53_RS07760	COG0037	tRNA processing
HRE53_RS07800	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_RS07805	COG0745	RESPONSE REGULATOR receiver
HRE53_RS07815	COG1858	cytochrome C peroxidase
HRE53_RS07820	COG2205	protein histidine kinase activity
HRE53_RS07820	COG0784	Response regulator, receiver
HRE53_RS07845	COG0434	BtpA family
HRE53_RS07850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_RS07855	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRE53_RS07875	COG3596	GTP binding
HRE53_RS07900	COG0307	riboflavin synthase, alpha
HRE53_RS07925	COG3220	belongs to the UPF0276 family
HRE53_RS07975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HRE53_RS08005	COG1233	COG1233 Phytoene dehydrogenase and related
HRE53_RS08035	COG2226	methyltransferase
HRE53_RS08040	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HRE53_RS08055	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRE53_RS08070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HRE53_RS08085	COG0017	Asparaginyl-tRNA synthetase
HRE53_RS08095	COG0297	glycogen (starch) synthase activity
HRE53_RS08100	COG0724	RNA recognition motif
HRE53_RS08125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRE53_RS08130	COG3977	Valine--pyruvate aminotransferase
HRE53_RS08160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HRE53_RS08190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRE53_RS08195	COG1007	ATP synthesis coupled electron transport
HRE53_RS08215	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HRE53_RS08220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRE53_RS08230	COG0742	ribosomal rna small subunit methyltransferase
HRE53_RS08280	COG0443	Heat shock 70 kDa protein
HRE53_RS08290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRE53_RS08295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRE53_RS08300	COG0460	homoserine dehydrogenase
HRE53_RS08310	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HRE53_RS08315	COG0456	acetyltransferase
HRE53_RS08330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRE53_RS08335	COG0616	signal peptide processing
HRE53_RS08365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRE53_RS08385	COG0793	Belongs to the peptidase S41A family
HRE53_RS08395	COG0747	negative chemotaxis
HRE53_RS08400	COG1858	cytochrome C peroxidase
HRE53_RS08405	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HRE53_RS08415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRE53_RS08435	COG3335	DDE superfamily endonuclease
HRE53_RS08450	COG1640	4-alpha-glucanotransferase
HRE53_RS08455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRE53_RS08480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS08485	COG0735	belongs to the Fur family
HRE53_RS08495	COG0572	uridine kinase
HRE53_RS08500	COG0058	SHG alpha-glucan phosphorylase activity
HRE53_RS08505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRE53_RS08515	COG2267	carboxylic ester hydrolase activity
HRE53_RS08520	COG0440	acetolactate synthase activity
HRE53_RS08540	COG0439	Biotin carboxylase
HRE53_RS08550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRE53_RS08555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRE53_RS08560	COG0542	response to heat
HRE53_RS08570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRE53_RS08580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_RS08590	COG0475	glutathione-regulated potassium exporter activity
HRE53_RS08600	COG0039	L-malate dehydrogenase activity
HRE53_RS08655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRE53_RS08655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRE53_RS08680	COG2062	phosphohistidine phosphatase, SixA
HRE53_RS08685	COG0372	Belongs to the citrate synthase family
HRE53_RS08690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRE53_RS08695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_RS08715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRE53_RS08760	COG0629	single-stranded DNA binding
HRE53_RS08765	COG0151	Belongs to the GarS family
HRE53_RS08795	COG0842	Transport permease protein
HRE53_RS08795	COG1131	(ABC) transporter
HRE53_RS08795	COG1716	ATPase activity
HRE53_RS08800	COG2815	serine threonine protein kinase
HRE53_RS08800	COG0515	serine threonine protein kinase
HRE53_RS08805	COG1253	flavin adenine dinucleotide binding
HRE53_RS08810	COG1178	ABC-type Fe3 transport system permease component
HRE53_RS08815	COG0445	tRNA wobble uridine modification
HRE53_RS08840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRE53_RS08845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRE53_RS08865	COG0517	IMP dehydrogenase activity
HRE53_RS08865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HRE53_RS08870	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HRE53_RS08880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HRE53_RS09005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRE53_RS09015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRE53_RS09035	COG2072	flavoprotein involved in K transport
HRE53_RS09040	COG5002	protein histidine kinase activity
HRE53_RS09040	COG5001	Diguanylate cyclase
HRE53_RS09070	COG2144	transferase activity, transferring acyl groups
HRE53_RS09130	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS09160	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_RS09180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRE53_RS09195	COG1597	lipid kinase activity
HRE53_RS09195	COG1803	Methylglyoxal synthase
HRE53_RS09200	COG0625	glutathione transferase activity
HRE53_RS09220	COG0583	DNA-binding transcription factor activity
HRE53_RS09235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HRE53_RS09260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRE53_RS09265	COG1494	fructose-1,6-bisphosphatase
HRE53_RS09275	COG0583	DNA-binding transcription factor activity
HRE53_RS09285	COG0456	acetyltransferase
HRE53_RS09285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HRE53_RS09315	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HRE53_RS09320	COG0156	8-amino-7-oxononanoate synthase activity
HRE53_RS09355	COG0596	Alpha beta hydrolase
HRE53_RS09380	COG0728	peptidoglycan biosynthetic process
HRE53_RS09395	COG2988	succinylglutamate desuccinylase activity
HRE53_RS09405	COG0728	peptidoglycan biosynthetic process
HRE53_RS09415	COG5001	Diguanylate cyclase
HRE53_RS09415	COG1716	ATPase activity
HRE53_RS09420	COG4221	oxidoreductase activity
HRE53_RS09425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRE53_RS09435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRE53_RS09460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRE53_RS09480	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRE53_RS09495	COG0442	prolyl-tRNA aminoacylation
HRE53_RS09515	COG0387	Pfam Sodium calcium exchanger
HRE53_RS09535	COG0740	serine-type endopeptidase activity
HRE53_RS09540	COG0740	serine-type endopeptidase activity
HRE53_RS09580	COG0564	pseudouridine synthase activity
HRE53_RS09595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS09600	COG1489	DNA binding
HRE53_RS09610	COG0602	queuosine metabolic process
HRE53_RS09615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRE53_RS09625	COG1040	competence protein
HRE53_RS09630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRE53_RS09630	COG0574	Belongs to the PEP-utilizing enzyme family
HRE53_RS09640	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRE53_RS09655	COG0739	heme binding
HRE53_RS09665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRE53_RS09680	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HRE53_RS09695	COG0714	Associated with various cellular activities
HRE53_RS09715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRE53_RS09720	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HRE53_RS09725	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HRE53_RS09750	COG0631	protein serine/threonine phosphatase activity
HRE53_RS09805	COG5001	Diguanylate cyclase
HRE53_RS09805	COG1716	ATPase activity
HRE53_RS09855	COG2176	DNA-directed DNA polymerase activity
HRE53_RS09890	COG0583	DNA-binding transcription factor activity
HRE53_RS09895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HRE53_RS09900	COG0563	adenylate kinase activity
HRE53_RS09905	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HRE53_RS09910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRE53_RS09920	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HRE53_RS09935	COG2154	pterin-4-alpha-carbinolamine dehydratase
HRE53_RS09940	COG0357	Ribosomal RNA small subunit methyltransferase G
HRE53_RS09945	COG3128	pkhd-type hydroxylase
HRE53_RS09955	COG4249	Peptidase C14 caspase catalytic subunit p20
HRE53_RS09955	COG2319	Wd-40 repeat
HRE53_RS09960	COG0415	Belongs to the DNA photolyase family
HRE53_RS09975	COG3693	PFAM glycoside hydrolase, family 10
HRE53_RS09995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_RS10015	COG0443	Heat shock 70 kDa protein
HRE53_RS10025	COG3328	transposase activity
HRE53_RS10045	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HRE53_RS10055	COG2885	chlorophyll binding
HRE53_RS10060	COG2885	chlorophyll binding
HRE53_RS10075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRE53_RS10090	COG0312	modulator of DNA gyrase
HRE53_RS10095	COG0312	modulator of DNA gyrase
HRE53_RS10100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HRE53_RS10110	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS10115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HRE53_RS10120	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS10170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRE53_RS10205	COG3001	Fructosamine kinase
HRE53_RS10225	COG1619	proteins homologs of microcin C7 resistance protein MccF
HRE53_RS10240	COG3118	belongs to the thioredoxin family
HRE53_RS10245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRE53_RS10250	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_RS10255	COG0714	Associated with various cellular activities
HRE53_RS10260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRE53_RS10270	COG2205	protein histidine kinase activity
HRE53_RS10275	COG2319	Wd-40 repeat
HRE53_RS10275	COG1672	PFAM Archaeal ATPase
HRE53_RS10280	COG0515	serine threonine protein kinase
HRE53_RS10285	COG0515	serine threonine protein kinase
HRE53_RS10285	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS10325	COG0587	DNA-directed DNA polymerase activity
HRE53_RS10330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRE53_RS10335	COG4245	von Willebrand factor, type A
HRE53_RS10350	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRE53_RS10365	COG0705	Rhomboid family
HRE53_RS10380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRE53_RS10385	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRE53_RS10390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRE53_RS10415	COG0464	growth
HRE53_RS10430	COG0525	valine-tRNA ligase activity
HRE53_RS10440	COG0724	RNA recognition motif
HRE53_RS10445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRE53_RS10465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRE53_RS10465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HRE53_RS10470	COG0436	Aminotransferase
HRE53_RS10495	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HRE53_RS10525	COG4447	cellulose binding
HRE53_RS10530	COG1773	rubredoxin
HRE53_RS10540	COG0012	GTP binding
HRE53_RS10545	COG1982	Orn Lys Arg decarboxylase major
HRE53_RS10560	COG0363	glucosamine-6-phosphate deaminase activity
HRE53_RS10565	COG1716	ATPase activity
HRE53_RS10570	COG0515	serine threonine protein kinase
HRE53_RS10570	COG2815	serine threonine protein kinase
HRE53_RS10590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRE53_RS10605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRE53_RS10605	COG4651	solute:proton antiporter activity
HRE53_RS10610	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRE53_RS10615	COG1234	tRNA 3'-trailer cleavage
HRE53_RS10620	COG0196	riboflavin kinase activity
HRE53_RS10625	COG0714	Associated with various cellular activities
HRE53_RS10645	COG1104	cysteine desulfurase activity
HRE53_RS10680	COG0739	heme binding
HRE53_RS10680	COG0741	lytic transglycosylase activity
HRE53_RS10680	COG1196	nuclear chromosome segregation
HRE53_RS10690	COG5001	Diguanylate cyclase
HRE53_RS10690	COG1716	ATPase activity
HRE53_RS10695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRE53_RS10725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRE53_RS10735	COG1252	NADH dehydrogenase
HRE53_RS10740	COG0450	alkyl hydroperoxide reductase
HRE53_RS10745	COG0463	Glycosyl transferase, family 2
HRE53_RS10760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HRE53_RS10785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRE53_RS10795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRE53_RS10825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_RS10830	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HRE53_RS10855	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRE53_RS10930	COG2198	Histidine kinase
HRE53_RS10930	COG2205	protein histidine kinase activity
HRE53_RS10930	COG0784	Response regulator, receiver
HRE53_RS10940	COG1595	DNA-templated transcription, initiation
HRE53_RS10985	COG3328	transposase activity
HRE53_RS11005	COG0358	DNA primase activity
HRE53_RS11010	COG3118	belongs to the thioredoxin family
HRE53_RS11015	COG1716	ATPase activity
HRE53_RS11030	COG0140	phosphoribosyl-ATP diphosphatase activity
HRE53_RS11030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRE53_RS11040	COG1716	ATPase activity
HRE53_RS11050	COG0475	glutathione-regulated potassium exporter activity
HRE53_RS11050	COG0589	response to stress
HRE53_RS11060	COG0431	NADPH-dependent FMN reductase
HRE53_RS11080	COG1695	Transcriptional regulator
HRE53_RS11085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRE53_RS11100	COG2852	Protein conserved in bacteria
HRE53_RS11115	COG2197	response regulator
HRE53_RS11125	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HRE53_RS11135	COG0393	Putative heavy-metal-binding
HRE53_RS11165	COG0247	lactate metabolic process
HRE53_RS11170	COG0277	FAD linked oxidase domain protein
HRE53_RS11205	COG2010	Cytochrome c
HRE53_RS11215	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HRE53_RS11245	COG0497	DNA recombination
HRE53_RS11260	COG0237	dephospho-CoA kinase activity
HRE53_RS11310	COG1053	succinate dehydrogenase
HRE53_RS11315	COG2165	general secretion pathway protein
HRE53_RS11325	COG1309	transcriptional regulator
HRE53_RS11330	COG4680	protein conserved in bacteria
HRE53_RS11340	COG2267	carboxylic ester hydrolase activity
HRE53_RS11345	COG2723	6-phospho-beta-galactosidase activity
HRE53_RS11350	COG0515	serine threonine protein kinase
HRE53_RS11350	COG3266	domain, Protein
HRE53_RS11365	COG1215	transferase activity, transferring glycosyl groups
HRE53_RS11380	COG2954	triphosphatase activity
HRE53_RS11390	COG5002	protein histidine kinase activity
HRE53_RS11395	COG1981	membrane
HRE53_RS11400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRE53_RS11410	COG1196	nuclear chromosome segregation
HRE53_RS11420	COG2894	cell division
HRE53_RS11440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HRE53_RS11450	COG3250	beta-galactosidase activity
HRE53_RS11455	COG3291	Pkd domain containing protein
HRE53_RS11460	COG1872	DUF167
HRE53_RS11475	COG0515	serine threonine protein kinase
HRE53_RS11475	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS11480	COG0515	serine threonine protein kinase
HRE53_RS11480	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS11510	COG0457	Tetratricopeptide repeat
HRE53_RS11535	COG0010	Belongs to the arginase family
HRE53_RS11540	COG0375	protein maturation
HRE53_RS11555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRE53_RS11560	COG1116	anion transmembrane transporter activity
HRE53_RS11570	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HRE53_RS11575	COG0515	serine threonine protein kinase
HRE53_RS11575	COG3266	domain, Protein
HRE53_RS11590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRE53_RS11615	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
HRE53_RS11640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HRE53_RS11645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRE53_RS11655	COG0717	Belongs to the dCTP deaminase family
HRE53_RS11660	COG3751	2OG-Fe(II) oxygenase superfamily
HRE53_RS11665	COG2099	Precorrin-6x reductase
HRE53_RS11670	COG5001	Diguanylate cyclase
HRE53_RS11670	COG1716	ATPase activity
HRE53_RS11675	COG0335	large ribosomal subunit rRNA binding
HRE53_RS11685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRE53_RS11690	COG0250	Participates in transcription elongation, termination and antitermination
HRE53_RS11695	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRE53_RS11700	COG0081	regulation of translation
HRE53_RS11705	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRE53_RS11710	COG0222	ribosome binding
HRE53_RS11715	COG1799	cell septum assembly
HRE53_RS11730	COG1131	(ABC) transporter
HRE53_RS11730	COG1716	ATPase activity
HRE53_RS11730	COG0842	Transport permease protein
HRE53_RS11735	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HRE53_RS11740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRE53_RS11745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRE53_RS11750	COG3409	Peptidoglycan-binding domain 1 protein
HRE53_RS11750	COG3429	Glucose-6-phosphate dehydrogenase subunit
HRE53_RS11760	COG1797	cobyrinic acid a,c-diamide synthase activity
HRE53_RS11770	COG0632	four-way junction helicase activity
HRE53_RS11785	COG0596	Alpha beta hydrolase
HRE53_RS11850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HRE53_RS11860	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRE53_RS11870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRE53_RS11890	COG0163	prenyltransferase activity
HRE53_RS11900	COG0346	lactoylglutathione lyase activity
HRE53_RS11910	COG0504	CTP synthase activity
HRE53_RS11915	COG1940	carbohydrate kinase activity
HRE53_RS11920	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRE53_RS11960	COG1253	flavin adenine dinucleotide binding
HRE53_RS11970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRE53_RS12020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRE53_RS12045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRE53_RS12055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRE53_RS12090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRE53_RS12140	COG4636	protein conserved in cyanobacteria
HRE53_RS12160	COG0515	serine threonine protein kinase
HRE53_RS12160	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS12165	COG1175	transmembrane transport
HRE53_RS12215	COG1131	(ABC) transporter
HRE53_RS12250	COG0038	chloride channel
HRE53_RS12260	COG1011	Hydrolase
HRE53_RS12295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRE53_RS12300	COG2223	nitrite transmembrane transporter activity
HRE53_RS12305	COG3659	wide pore channel activity
HRE53_RS12310	COG0243	molybdopterin cofactor binding
HRE53_RS12315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRE53_RS12320	COG0778	Nitroreductase
HRE53_RS12370	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HRE53_RS12380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRE53_RS12420	COG2166	iron-sulfur cluster assembly
HRE53_RS12425	COG0523	cobalamin synthesis protein
HRE53_RS12460	COG3220	belongs to the UPF0276 family
HRE53_RS12490	COG0523	cobalamin synthesis protein
HRE53_RS12525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HRE53_RS12545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_RS12555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRE53_RS12555	COG4451	ribulose bisphosphate carboxylase, small
HRE53_RS12570	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRE53_RS12575	COG0302	gtp cyclohydrolase
HRE53_RS12580	COG0523	cobalamin synthesis protein
HRE53_RS12615	COG3328	transposase activity
HRE53_RS12625	COG0523	cobalamin synthesis protein
HRE53_RS12630	COG0113	porphobilinogen synthase activity
HRE53_RS12635	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRE53_RS12635	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRE53_RS12640	COG1121	(ABC) transporter
HRE53_RS12645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRE53_RS12655	COG3328	transposase activity
HRE53_RS12690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRE53_RS12695	COG1472	Belongs to the glycosyl hydrolase 3 family
HRE53_RS12715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRE53_RS12720	COG0321	lipoyl(octanoyl) transferase activity
HRE53_RS12725	COG0314	molybdopterin synthase activity
HRE53_RS12740	COG0706	membrane insertase activity
HRE53_RS12750	COG0594	ribonuclease P activity
HRE53_RS12755	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRE53_RS12760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRE53_RS12765	COG0592	DNA-directed DNA polymerase activity
HRE53_RS12780	COG0463	Glycosyl transferase, family 2
HRE53_RS12785	COG0745	RESPONSE REGULATOR receiver
HRE53_RS12790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRE53_RS12795	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HRE53_RS12800	COG2211	Major facilitator Superfamily
HRE53_RS12825	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_RS12845	COG1012	belongs to the aldehyde dehydrogenase family
HRE53_RS12860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRE53_RS12875	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HRE53_RS12890	COG4251	negative regulation of phosphorylation
HRE53_RS12900	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRE53_RS12910	COG2027	D-alanyl-D-alanine carboxypeptidase
HRE53_RS12940	COG3328	transposase activity
HRE53_RS12955	COG0681	Belongs to the peptidase S26 family
HRE53_RS12965	COG0129	dihydroxy-acid dehydratase activity
HRE53_RS12990	COG3903	Transcriptional regulator
HRE53_RS12990	COG2319	Wd-40 repeat
HRE53_RS12995	COG0824	Thioesterase
HRE53_RS13030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRE53_RS13035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_RS13045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRE53_RS13055	COG3842	ATPase activity
HRE53_RS13060	COG0515	serine threonine protein kinase
HRE53_RS13060	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS13065	COG0629	single-stranded DNA binding
HRE53_RS13070	COG0628	permease
HRE53_RS13075	COG0752	glycyl-tRNA synthetase alpha subunit
HRE53_RS13105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRE53_RS13120	COG0316	Belongs to the HesB IscA family
HRE53_RS13160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRE53_RS13165	COG2274	protein secretion by the type I secretion system
HRE53_RS13190	COG4978	Transcriptional regulator
HRE53_RS13190	COG0789	Transcriptional regulator
HRE53_RS13205	COG3266	domain, Protein
HRE53_RS13205	COG0515	serine threonine protein kinase
HRE53_RS13225	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRE53_RS13225	COG2273	Hydrolase Family 16
HRE53_RS13235	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS13240	COG0659	secondary active sulfate transmembrane transporter activity
HRE53_RS13245	COG0475	glutathione-regulated potassium exporter activity
HRE53_RS13250	COG1006	Multisubunit Na H antiporter MnhC subunit
HRE53_RS13315	COG0459	protein refolding
HRE53_RS13335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_RS13350	COG0492	ferredoxin-NADP+ reductase activity
HRE53_RS13375	COG0745	RESPONSE REGULATOR receiver
HRE53_RS13385	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_RS13390	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_RS13395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS13405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_RS13410	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRE53_RS13410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRE53_RS13415	COG3328	transposase activity
HRE53_RS13425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HRE53_RS13525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRE53_RS13580	COG0251	oxidation-reduction process
HRE53_RS13595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRE53_RS13595	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HRE53_RS13625	COG0028	Belongs to the TPP enzyme family
HRE53_RS13640	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HRE53_RS13655	COG0469	pyruvate kinase activity
HRE53_RS13660	COG1959	2 iron, 2 sulfur cluster binding
HRE53_RS13705	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HRE53_RS13710	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HRE53_RS13720	COG5001	Diguanylate cyclase
HRE53_RS13720	COG5002	protein histidine kinase activity
HRE53_RS13725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRE53_RS13735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRE53_RS13740	COG0649	NAD binding
HRE53_RS13760	COG1063	alcohol dehydrogenase
HRE53_RS13780	COG1063	alcohol dehydrogenase
HRE53_RS13785	COG1063	alcohol dehydrogenase
HRE53_RS13790	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRE53_RS13810	COG0346	lactoylglutathione lyase activity
HRE53_RS13830	COG0625	glutathione transferase activity
HRE53_RS13835	COG1902	pentaerythritol trinitrate reductase activity
HRE53_RS13850	COG4221	oxidoreductase activity
HRE53_RS13855	COG1064	alcohol dehydrogenase
HRE53_RS13865	COG3266	domain, Protein
HRE53_RS13865	COG0515	serine threonine protein kinase
HRE53_RS13870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRE53_RS13885	COG2211	Major facilitator Superfamily
HRE53_RS13890	COG1722	exodeoxyribonuclease VII activity
HRE53_RS13895	COG1570	exodeoxyribonuclease VII activity
HRE53_RS13900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRE53_RS13905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRE53_RS13950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRE53_RS13970	COG1120	ATPase activity
HRE53_RS13975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRE53_RS13990	COG0492	ferredoxin-NADP+ reductase activity
HRE53_RS14005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRE53_RS14055	COG3588	fructose-bisphosphate aldolase
HRE53_RS14070	COG3128	pkhd-type hydroxylase
HRE53_RS14095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRE53_RS14115	COG3335	DDE superfamily endonuclease
HRE53_RS14120	COG2207	Transcriptional regulator
HRE53_RS14125	COG4771	TonB-dependent receptor
HRE53_RS14140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRE53_RS14155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRE53_RS14200	COG0783	Belongs to the Dps family
HRE53_RS14205	COG0848	biopolymer transport protein
HRE53_RS14210	COG0811	peptide transport
HRE53_RS14230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRE53_RS14235	COG1120	ATPase activity
HRE53_RS14240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HRE53_RS14255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_RS14290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRE53_RS14295	COG0052	Belongs to the universal ribosomal protein uS2 family
HRE53_RS14300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HRE53_RS14320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRE53_RS14325	COG0768	penicillin binding
HRE53_RS14330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRE53_RS14360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HRE53_RS14365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRE53_RS14370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRE53_RS14375	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRE53_RS14380	COG0740	serine-type endopeptidase activity
HRE53_RS14385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRE53_RS14390	COG2267	carboxylic ester hydrolase activity
HRE53_RS14400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HRE53_RS14410	COG5001	Diguanylate cyclase
HRE53_RS14410	COG5002	protein histidine kinase activity
HRE53_RS14425	COG0456	acetyltransferase
HRE53_RS14450	COG0288	reversible hydration of carbon dioxide
HRE53_RS14460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRE53_RS14495	COG5002	protein histidine kinase activity
HRE53_RS14500	COG0745	RESPONSE REGULATOR receiver
HRE53_RS14530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRE53_RS14545	COG0573	inorganic phosphate transmembrane transporter activity
HRE53_RS14555	COG0640	Transcriptional regulator
HRE53_RS14585	COG3328	transposase activity
HRE53_RS14590	COG1733	regulation of RNA biosynthetic process
HRE53_RS14595	COG1902	pentaerythritol trinitrate reductase activity
HRE53_RS14605	COG4249	Peptidase C14 caspase catalytic subunit p20
HRE53_RS14605	COG2319	Wd-40 repeat
HRE53_RS14610	COG4249	Peptidase C14 caspase catalytic subunit p20
HRE53_RS14610	COG2319	Wd-40 repeat
HRE53_RS14640	COG1748	Saccharopine dehydrogenase
HRE53_RS14645	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HRE53_RS14655	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRE53_RS14670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HRE53_RS14675	COG0204	Acyl-transferase
HRE53_RS14675	COG0318	PFAM AMP-dependent synthetase and ligase
HRE53_RS14685	COG0242	peptide deformylase activity
HRE53_RS14715	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HRE53_RS14720	COG0010	Belongs to the arginase family
HRE53_RS14730	COG0154	amidase activity
HRE53_RS14740	COG0004	ammonium transporteR
HRE53_RS14800	COG2385	sporulation resulting in formation of a cellular spore
HRE53_RS14835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRE53_RS14840	COG3540	Alkaline phosphatase
HRE53_RS14860	COG4221	oxidoreductase activity
HRE53_RS14895	COG2124	cytochrome p450
HRE53_RS14900	COG0753	catalase activity
HRE53_RS14905	COG2815	serine threonine protein kinase
HRE53_RS14905	COG0515	serine threonine protein kinase
HRE53_RS14910	COG2204	response regulator
HRE53_RS14915	COG4191	Histidine kinase
HRE53_RS14915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_RS14920	COG3437	response regulator, receiver
HRE53_RS14920	COG0784	Response regulator, receiver
HRE53_RS14925	COG4251	negative regulation of phosphorylation
HRE53_RS14925	COG5001	Diguanylate cyclase
HRE53_RS14925	COG3706	GGDEF domain
HRE53_RS14925	COG2203	Gaf domain
HRE53_RS14930	COG0116	Belongs to the methyltransferase superfamily
HRE53_RS14945	COG0822	iron-sulfur transferase activity
HRE53_RS14955	COG0371	Dehydrogenase
HRE53_RS14960	COG0436	Aminotransferase
HRE53_RS14965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRE53_RS14970	COG0569	domain protein
HRE53_RS14975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRE53_RS14985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HRE53_RS14990	COG0406	alpha-ribazole phosphatase activity
HRE53_RS15020	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRE53_RS15025	COG0268	Binds directly to 16S ribosomal RNA
HRE53_RS15030	COG0084	hydrolase, TatD family'
HRE53_RS15035	COG0085	RNA polymerase activity
HRE53_RS15040	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRE53_RS15050	COG0534	Mate efflux family protein
HRE53_RS15070	COG2022	thiamine diphosphate biosynthetic process
HRE53_RS15075	COG1595	DNA-templated transcription, initiation
HRE53_RS15085	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HRE53_RS15130	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS15140	COG2226	methyltransferase
HRE53_RS15170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRE53_RS15210	COG0673	inositol 2-dehydrogenase activity
HRE53_RS15240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRE53_RS15245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRE53_RS15250	COG0799	negative regulation of ribosome biogenesis
HRE53_RS15270	COG0628	permease
HRE53_RS15275	COG0628	permease
HRE53_RS15290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRE53_RS15305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRE53_RS15310	COG1215	transferase activity, transferring glycosyl groups
HRE53_RS15320	COG3769	mannosylglycerate metabolic process
HRE53_RS15330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRE53_RS15355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRE53_RS15390	COG2082	Precorrin-8x methylmutase
HRE53_RS15405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HRE53_RS15415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRE53_RS15430	COG0483	inositol monophosphate 1-phosphatase activity
HRE53_RS15440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRE53_RS15450	COG0300	oxidoreductase activity
HRE53_RS15465	COG0735	belongs to the Fur family
HRE53_RS15475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRE53_RS15485	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HRE53_RS15520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRE53_RS15520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRE53_RS15535	COG0343	queuine tRNA-ribosyltransferase activity
HRE53_RS15545	COG0701	Predicted permease
HRE53_RS15555	COG0784	Response regulator, receiver
HRE53_RS15555	COG2198	Histidine kinase
HRE53_RS15555	COG2205	protein histidine kinase activity
HRE53_RS15565	COG2197	response regulator
HRE53_RS15580	COG3263	regulation of cellular component size
HRE53_RS15610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HRE53_RS15620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRE53_RS15635	COG0667	Aldo Keto reductase
HRE53_RS15640	COG0667	Aldo Keto reductase
HRE53_RS15650	COG3903	Transcriptional regulator
HRE53_RS15650	COG2319	Wd-40 repeat
HRE53_RS15665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HRE53_RS15685	COG3128	pkhd-type hydroxylase
HRE53_RS15710	COG5001	Diguanylate cyclase
HRE53_RS15710	COG3706	GGDEF domain
HRE53_RS15710	COG4251	negative regulation of phosphorylation
HRE53_RS15710	COG2203	Gaf domain
HRE53_RS15730	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HRE53_RS15735	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_RS15755	COG0667	Aldo Keto reductase
HRE53_RS15775	COG0589	response to stress
HRE53_RS15785	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HRE53_RS15790	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HRE53_RS15790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRE53_RS15805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRE53_RS15810	COG1131	(ABC) transporter
HRE53_RS15810	COG0842	Transport permease protein
HRE53_RS15810	COG1716	ATPase activity
HRE53_RS15815	COG3266	domain, Protein
HRE53_RS15815	COG0515	serine threonine protein kinase
HRE53_RS15825	COG0745	RESPONSE REGULATOR receiver
HRE53_RS15840	COG0861	Integral membrane protein TerC family
HRE53_RS15865	COG0105	UTP biosynthetic process
HRE53_RS15870	COG0671	phosphoesterase, PA-phosphatase related
HRE53_RS15880	COG3328	transposase activity
HRE53_RS15900	COG2198	Histidine kinase
HRE53_RS15900	COG0643	Histidine kinase
HRE53_RS15900	COG0784	Response regulator, receiver
HRE53_RS15905	COG2203	Gaf domain
HRE53_RS15905	COG0840	transmembrane signaling receptor activity
HRE53_RS15920	COG0784	Response regulator, receiver
HRE53_RS15930	COG5002	protein histidine kinase activity
HRE53_RS15930	COG2205	protein histidine kinase activity
HRE53_RS15930	COG0784	Response regulator, receiver
HRE53_RS15935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRE53_RS15945	COG1876	peptidase activity
HRE53_RS15950	COG3266	domain, Protein
HRE53_RS15950	COG0515	serine threonine protein kinase
HRE53_RS15955	COG4948	Mandelate Racemase Muconate Lactonizing
HRE53_RS15960	COG0318	PFAM AMP-dependent synthetase and ligase
HRE53_RS15990	COG3239	Fatty acid desaturase
HRE53_RS16075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRE53_RS16090	COG1132	(ABC) transporter
HRE53_RS16120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRE53_RS16125	COG0552	protein localization to endoplasmic reticulum
HRE53_RS16130	COG2208	phosphoserine phosphatase activity
HRE53_RS16140	COG0006	proline dipeptidase activity
HRE53_RS16185	COG0308	aminopeptidase N
HRE53_RS16215	COG0432	Pfam Uncharacterised protein family UPF0047
HRE53_RS16245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRE53_RS16260	COG1940	carbohydrate kinase activity
HRE53_RS16290	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRE53_RS16300	COG2161	toxin-antitoxin pair type II binding
HRE53_RS16305	COG2226	methyltransferase
HRE53_RS16320	COG1201	RNA secondary structure unwinding
HRE53_RS16325	COG4251	negative regulation of phosphorylation
HRE53_RS16330	COG4251	negative regulation of phosphorylation
HRE53_RS16335	COG0745	RESPONSE REGULATOR receiver
HRE53_RS16340	COG5001	Diguanylate cyclase
HRE53_RS16340	COG4251	negative regulation of phosphorylation
HRE53_RS16340	COG3706	GGDEF domain
HRE53_RS16340	COG2203	Gaf domain
HRE53_RS16345	COG5002	protein histidine kinase activity
HRE53_RS16345	COG5001	Diguanylate cyclase
HRE53_RS16350	COG0484	heat shock protein binding
HRE53_RS16360	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_RS16365	COG2081	HI0933 family
HRE53_RS16370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRE53_RS16380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HRE53_RS16390	COG2010	Cytochrome c
HRE53_RS16395	COG2010	Cytochrome c
HRE53_RS16400	COG2010	Cytochrome c
HRE53_RS16415	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_RS16425	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HRE53_RS16435	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRE53_RS16495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRE53_RS16505	COG4115	mRNA cleavage
HRE53_RS16540	COG0515	serine threonine protein kinase
HRE53_RS16540	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS16555	COG0745	RESPONSE REGULATOR receiver
HRE53_RS16560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRE53_RS16565	COG1194	a g-specific adenine glycosylase
HRE53_RS16580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS16585	COG2091	lysine biosynthetic process via aminoadipic acid
HRE53_RS16590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRE53_RS16590	COG0426	domain, Protein
HRE53_RS16615	COG0511	ligase activity, forming carbon-carbon bonds
HRE53_RS16620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRE53_RS16640	COG3932	Exopolysaccharide synthesis, ExoD
HRE53_RS16645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HRE53_RS16665	COG0181	hydroxymethylbilane synthase activity
HRE53_RS16685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRE53_RS16690	COG0205	6-phosphofructokinase activity
HRE53_RS16695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRE53_RS16705	COG2319	Wd-40 repeat
HRE53_RS16705	COG3903	Transcriptional regulator
HRE53_RS16710	COG0515	serine threonine protein kinase
HRE53_RS16720	COG0792	nuclease activity
HRE53_RS16730	COG0747	negative chemotaxis
HRE53_RS16735	COG0633	Ferredoxin
HRE53_RS16770	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRE53_RS16775	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HRE53_RS16785	COG1555	photosystem II stabilization
HRE53_RS16795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRE53_RS16840	COG0148	phosphopyruvate hydratase activity
HRE53_RS16845	COG0346	lactoylglutathione lyase activity
HRE53_RS16850	COG3659	wide pore channel activity
HRE53_RS16855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRE53_RS16860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRE53_RS16865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRE53_RS16880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRE53_RS16885	COG0483	inositol monophosphate 1-phosphatase activity
HRE53_RS16890	COG0484	heat shock protein binding
HRE53_RS16895	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HRE53_RS16900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRE53_RS16930	COG0436	Aminotransferase
HRE53_RS16935	COG1842	Phage shock protein A
HRE53_RS16945	COG0667	Aldo Keto reductase
HRE53_RS16950	COG0372	Belongs to the citrate synthase family
HRE53_RS17105	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
HRE53_RS17110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRE53_RS17120	COG0515	serine threonine protein kinase
HRE53_RS17140	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HRE53_RS17145	COG5322	oxidoreductase activity
HRE53_RS17180	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HRE53_RS17190	COG0745	RESPONSE REGULATOR receiver
HRE53_RS17195	COG4581	dead DEAH box helicase
HRE53_RS17200	COG0643	Histidine kinase
HRE53_RS17200	COG2198	Histidine kinase
HRE53_RS17205	COG0840	transmembrane signaling receptor activity
HRE53_RS17225	COG1573	uracil-dna glycosylase
HRE53_RS17240	COG0750	zinc metalloprotease
HRE53_RS17245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HRE53_RS17250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRE53_RS17265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRE53_RS17270	COG0215	cysteine-tRNA ligase activity
HRE53_RS17280	COG5001	Diguanylate cyclase
HRE53_RS17280	COG1716	ATPase activity
HRE53_RS17290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_RS17320	COG2855	membrane
HRE53_RS17340	COG3265	gluconokinase activity
HRE53_RS17345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRE53_RS17350	COG1121	(ABC) transporter
HRE53_RS17355	COG0228	four-way junction DNA binding
HRE53_RS17365	COG1702	phosphate starvation-inducible protein PhoH
HRE53_RS17380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRE53_RS17390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRE53_RS17410	COG0702	epimerase
HRE53_RS17425	COG2183	response to ionizing radiation
HRE53_RS17440	COG3328	transposase activity
HRE53_RS17465	COG3328	transposase activity
HRE53_RS17485	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRE53_RS17490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRE53_RS17540	COG0006	proline dipeptidase activity
HRE53_RS17545	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS17555	COG0456	acetyltransferase
HRE53_RS17560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRE53_RS17585	COG0697	spore germination
HRE53_RS17600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HRE53_RS17615	COG1285	pathogenesis
HRE53_RS17620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRE53_RS17625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_RS17625	COG5549	protein import
HRE53_RS17660	COG0583	DNA-binding transcription factor activity
HRE53_RS17705	COG0347	Belongs to the P(II) protein family
HRE53_RS17720	COG0697	spore germination
HRE53_RS17770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRE53_RS17785	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HRE53_RS17785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRE53_RS17800	COG1672	PFAM Archaeal ATPase
HRE53_RS17800	COG2319	Wd-40 repeat
HRE53_RS17830	COG2255	four-way junction helicase activity
HRE53_RS17835	COG1690	Belongs to the RtcB family
HRE53_RS17840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRE53_RS17860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRE53_RS17865	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HRE53_RS17875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_RS17915	COG1104	cysteine desulfurase activity
HRE53_RS17955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRE53_RS17970	COG1214	PFAM Peptidase M22, glycoprotease
HRE53_RS17975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRE53_RS17985	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HRE53_RS17990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRE53_RS17990	COG0519	Catalyzes the synthesis of GMP from XMP
HRE53_RS18000	COG2205	protein histidine kinase activity
HRE53_RS18000	COG2202	Pas domain
HRE53_RS18030	COG0534	Mate efflux family protein
HRE53_RS18040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRE53_RS18055	COG1132	(ABC) transporter
HRE53_RS18070	COG3258	Cytochrome c
HRE53_RS18085	COG0805	protein transport
HRE53_RS18090	COG2259	Doxx family
HRE53_RS18120	COG0793	Belongs to the peptidase S41A family
HRE53_RS18125	COG1346	cytolysis
HRE53_RS18130	COG1346	cytolysis
HRE53_RS18135	COG1380	Effector of murein hydrolase LrgA
HRE53_RS18140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRE53_RS18215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRE53_RS18250	COG0745	RESPONSE REGULATOR receiver
HRE53_RS18255	COG1672	PFAM Archaeal ATPase
HRE53_RS18255	COG2319	Wd-40 repeat
HRE53_RS18260	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS18290	COG0519	Catalyzes the synthesis of GMP from XMP
HRE53_RS18310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRE53_RS18325	COG0170	dolichyl monophosphate biosynthetic process
HRE53_RS18340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRE53_RS18345	COG0023	Translation Initiation Factor
HRE53_RS18380	COG0788	formyltetrahydrofolate deformylase activity
HRE53_RS18410	COG1070	Carbohydrate kinase
HRE53_RS18450	COG0395	ABC-type sugar transport system, permease component
HRE53_RS18460	COG0165	Argininosuccinate lyase
HRE53_RS18470	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HRE53_RS18475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRE53_RS18480	COG0459	protein refolding
HRE53_RS18515	COG1333	cytochrome c biogenesis protein
HRE53_RS18515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRE53_RS18560	COG0741	lytic transglycosylase activity
HRE53_RS18560	COG1196	nuclear chromosome segregation
HRE53_RS18560	COG0739	heme binding
HRE53_RS18565	COG1132	(ABC) transporter
HRE53_RS18575	COG0149	triose-phosphate isomerase activity
HRE53_RS18580	COG0583	DNA-binding transcription factor activity
HRE53_RS18585	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRE53_RS18590	COG0746	molybdenum cofactor guanylyltransferase activity
HRE53_RS18610	COG0531	amino acid
HRE53_RS18625	COG0210	DNA helicase
HRE53_RS18635	COG1304	FMN binding
HRE53_RS18640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_RS18650	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HRE53_RS18650	COG3264	Mechanosensitive ion channel
HRE53_RS18665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HRE53_RS18670	COG2003	Belongs to the UPF0758 family
HRE53_RS18675	COG0284	orotidine-5'-phosphate decarboxylase activity
HRE53_RS18680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRE53_RS18690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_RS18700	COG1994	Peptidase M50
HRE53_RS18700	COG0517	IMP dehydrogenase activity
HRE53_RS18705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRE53_RS18710	COG0134	indole-3-glycerol-phosphate synthase activity
HRE53_RS18725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRE53_RS18730	COG1187	pseudouridine synthase activity
HRE53_RS18740	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
HRE53_RS18745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_RS18750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRE53_RS18755	COG1691	(AIR) carboxylase
HRE53_RS18765	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HRE53_RS18770	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HRE53_RS18775	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS18780	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HRE53_RS18805	COG3210	domain, Protein
HRE53_RS18835	COG0686	Belongs to the AlaDH PNT family
HRE53_RS18845	COG2890	protein-(glutamine-N5) methyltransferase activity
HRE53_RS18870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRE53_RS18885	COG0515	serine threonine protein kinase
HRE53_RS18895	COG3064	Membrane
HRE53_RS18895	COG0515	serine threonine protein kinase
HRE53_RS18895	COG4991	sh3 domain protein
HRE53_RS18900	COG0515	serine threonine protein kinase
HRE53_RS18905	COG0072	phenylalanine-tRNA ligase activity
HRE53_RS18905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRE53_RS18910	COG2203	Gaf domain
HRE53_RS18910	COG3706	GGDEF domain
HRE53_RS18910	COG4251	negative regulation of phosphorylation
HRE53_RS18910	COG5001	Diguanylate cyclase
HRE53_RS18990	COG4251	negative regulation of phosphorylation
HRE53_RS18995	COG0784	Response regulator, receiver
HRE53_RS19000	COG3447	MASE1 domain protein
HRE53_RS19000	COG5001	Diguanylate cyclase
HRE53_RS19000	COG5002	protein histidine kinase activity
HRE53_RS19015	COG2340	Cysteine-rich secretory protein family
HRE53_RS19020	COG2304	oxidoreductase activity
HRE53_RS19025	COG0640	Transcriptional regulator
HRE53_RS19030	COG2912	Transglutaminase-like superfamily
HRE53_RS19035	COG5002	protein histidine kinase activity
HRE53_RS19045	COG0557	exoribonuclease II activity
HRE53_RS19120	COG0137	argininosuccinate synthase activity
HRE53_RS19140	COG1077	Cell shape determining protein MreB Mrl
HRE53_RS19145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HRE53_RS19155	COG1492	cobalamin metabolic process
HRE53_RS19165	COG3956	TIGRFAM MazG family protein
HRE53_RS19225	COG2205	protein histidine kinase activity
HRE53_RS19230	COG3022	response to hydroperoxide
HRE53_RS19235	COG2226	methyltransferase
HRE53_RS19260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_RS19270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS19285	COG1132	(ABC) transporter
HRE53_RS19290	COG0745	RESPONSE REGULATOR receiver
HRE53_RS19325	COG2022	thiamine diphosphate biosynthetic process
HRE53_RS19325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRE53_RS19330	COG0009	L-threonylcarbamoyladenylate synthase
HRE53_RS19340	COG3655	Transcriptional regulator
HRE53_RS19390	COG2897	thiosulfate sulfurtransferase activity
HRE53_RS19395	COG4566	intracellular signal transduction
HRE53_RS19455	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRE53_RS19460	COG0563	adenylate kinase activity
HRE53_RS19465	COG0201	protein transport
HRE53_RS19470	COG0200	Binds to the 23S rRNA
HRE53_RS19475	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRE53_RS19480	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRE53_RS19485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRE53_RS19490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRE53_RS19495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRE53_RS19500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRE53_RS19505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRE53_RS19510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRE53_RS19515	COG0255	Belongs to the universal ribosomal protein uL29 family
HRE53_RS19520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRE53_RS19525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRE53_RS19530	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRE53_RS19535	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRE53_RS19540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRE53_RS19545	COG0089	rRNA binding
HRE53_RS19550	COG0088	Forms part of the polypeptide exit tunnel
HRE53_RS19555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRE53_RS19625	COG2226	methyltransferase
HRE53_RS19635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRE53_RS19660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRE53_RS19665	COG0328	RNA-DNA hybrid ribonuclease activity
HRE53_RS19675	COG1078	dGTPase activity
HRE53_RS19680	COG0793	Belongs to the peptidase S41A family
HRE53_RS19685	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HRE53_RS19690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HRE53_RS19695	COG0242	peptide deformylase activity
HRE53_RS19700	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRE53_RS19700	COG0758	DNA mediated transformation
HRE53_RS19705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRE53_RS19710	COG3239	Fatty acid desaturase
HRE53_RS19715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRE53_RS19730	COG1595	DNA-templated transcription, initiation
HRE53_RS19740	COG1587	Uroporphyrinogen-III synthase
HRE53_RS19765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRE53_RS19775	COG0850	regulation of cytokinetic process
HRE53_RS19780	COG2894	cell division
HRE53_RS19790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HRE53_RS19795	COG1543	Belongs to the glycosyl hydrolase 57 family
HRE53_RS19820	COG0297	glycogen (starch) synthase activity
HRE53_RS19820	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS19830	COG1381	Involved in DNA repair and RecF pathway recombination
HRE53_RS19835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRE53_RS19850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HRE53_RS19885	COG0109	protoheme IX farnesyltransferase activity
HRE53_RS19890	COG1612	heme a metabolic process
HRE53_RS19895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HRE53_RS19900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRE53_RS19905	COG1845	cytochrome c oxidase, subunit III
HRE53_RS19910	COG0157	Belongs to the NadC ModD family
HRE53_RS19915	COG0583	DNA-binding transcription factor activity
HRE53_RS19920	COG0515	serine threonine protein kinase
HRE53_RS19945	COG1672	PFAM Archaeal ATPase
HRE53_RS19945	COG2319	Wd-40 repeat
HRE53_RS19965	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HRE53_RS19975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRE53_RS20000	COG4989	oxidoreductase activity
HRE53_RS20015	COG0259	pyridoxamine-phosphate oxidase activity
HRE53_RS20035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRE53_RS20045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_RS20065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS20070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_RS20080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_RS20090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRE53_RS20100	COG0857	belongs to the CobB CobQ family
HRE53_RS20110	COG0535	radical SAM domain protein
HRE53_RS20115	COG1215	transferase activity, transferring glycosyl groups
HRE53_RS20120	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HRE53_RS20130	COG1490	D-aminoacyl-tRNA deacylase activity
HRE53_RS20135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRE53_RS20140	COG0539	negative regulation of cytoplasmic translation
HRE53_RS20150	COG2203	Gaf domain
HRE53_RS20150	COG3706	GGDEF domain
HRE53_RS20150	COG4251	negative regulation of phosphorylation
HRE53_RS20150	COG5001	Diguanylate cyclase
HRE53_RS20155	COG0714	Associated with various cellular activities
HRE53_RS20160	COG0714	Associated with various cellular activities
HRE53_RS20185	COG2052	Domain of unknown function (DUF370)
HRE53_RS20190	COG0194	GDP metabolic process
HRE53_RS20200	COG0450	alkyl hydroperoxide reductase
HRE53_RS20210	COG0347	Belongs to the P(II) protein family
HRE53_RS20215	COG0154	amidase activity
HRE53_RS20230	COG0557	exoribonuclease II activity
HRE53_RS20235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRE53_RS20240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRE53_RS20280	COG1324	tolerance protein
HRE53_RS20295	COG1562	ergosterol biosynthetic process
HRE53_RS20305	COG2226	methyltransferase
HRE53_RS20350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HRE53_RS20360	COG0640	Transcriptional regulator
HRE53_RS20365	COG3118	belongs to the thioredoxin family
HRE53_RS20370	COG1902	pentaerythritol trinitrate reductase activity
HRE53_RS20385	COG1879	ABC-type sugar transport system periplasmic component
HRE53_RS20390	COG1657	PFAM Prenyltransferase squalene oxidase
HRE53_RS20415	COG0793	Belongs to the peptidase S41A family
HRE53_RS20425	COG1429	ligase activity, forming nitrogen-metal bonds
HRE53_RS20435	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HRE53_RS20445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRE53_RS20470	COG0612	Peptidase, M16
HRE53_RS20475	COG0612	Peptidase, M16
HRE53_RS20485	COG0489	protein tyrosine kinase activity
HRE53_RS20525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRE53_RS20535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRE53_RS20565	COG0133	tryptophan synthase activity
HRE53_RS20575	COG0113	porphobilinogen synthase activity
HRE53_RS20620	COG2205	protein histidine kinase activity
HRE53_RS20620	COG3850	Histidine kinase
HRE53_RS20620	COG4999	Histidine kinase
HRE53_RS20620	COG3437	response regulator, receiver
HRE53_RS20690	COG1716	ATPase activity
HRE53_RS20690	COG5001	Diguanylate cyclase
HRE53_RS20695	COG0018	arginyl-trna synthetase
HRE53_RS20710	COG2226	methyltransferase
HRE53_RS20715	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HRE53_RS20720	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS20720	COG0515	serine threonine protein kinase
HRE53_RS20735	COG1316	TRANSCRIPTIONal
HRE53_RS20745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRE53_RS20750	COG1063	alcohol dehydrogenase
HRE53_RS20760	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HRE53_RS20765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HRE53_RS20770	COG0539	negative regulation of cytoplasmic translation
HRE53_RS20775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRE53_RS20800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRE53_RS20805	COG2046	Belongs to the sulfate adenylyltransferase family
HRE53_RS20825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRE53_RS20830	COG0786	glutamate:sodium symporter activity
HRE53_RS20845	COG0745	RESPONSE REGULATOR receiver
HRE53_RS20850	COG5002	protein histidine kinase activity
HRE53_RS20870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRE53_RS20875	COG0481	GTPase activity
HRE53_RS20885	COG0501	Belongs to the peptidase M48B family
HRE53_RS20920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HRE53_RS20945	COG2032	superoxide dismutase activity
HRE53_RS21005	COG3264	Mechanosensitive ion channel
HRE53_RS21005	COG1196	nuclear chromosome segregation
HRE53_RS21015	COG5001	Diguanylate cyclase
HRE53_RS21015	COG1716	ATPase activity
HRE53_RS21030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRE53_RS21040	COG0756	dUTP diphosphatase activity
HRE53_RS21045	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRE53_RS21120	COG0515	serine threonine protein kinase
HRE53_RS21120	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS21140	COG3937	granule-associated protein
HRE53_RS21150	COG0783	Belongs to the Dps family
HRE53_RS21160	COG0673	inositol 2-dehydrogenase activity
HRE53_RS21170	COG1366	Belongs to the anti-sigma-factor antagonist family
HRE53_RS21180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRE53_RS21195	COG0505	Belongs to the CarA family
HRE53_RS21200	COG1716	ATPase activity
HRE53_RS21210	COG1175	transmembrane transport
HRE53_RS21215	COG1077	Cell shape determining protein MreB Mrl
HRE53_RS21230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRE53_RS21235	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HRE53_RS21240	COG1408	metallophosphoesterase
HRE53_RS21250	COG3266	domain, Protein
HRE53_RS21250	COG0515	serine threonine protein kinase
HRE53_RS21285	COG5002	protein histidine kinase activity
HRE53_RS21290	COG0745	RESPONSE REGULATOR receiver
HRE53_RS21300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRE53_RS21305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HRE53_RS21305	COG1116	anion transmembrane transporter activity
HRE53_RS21310	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HRE53_RS21315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRE53_RS21360	COG2124	cytochrome p450
HRE53_RS21365	COG5001	Diguanylate cyclase
HRE53_RS21365	COG3300	MHYT domain
HRE53_RS21380	COG0514	ATP-dependent DNA helicase (RecQ)
HRE53_RS21385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_RS21405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRE53_RS21430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRE53_RS21435	COG0009	L-threonylcarbamoyladenylate synthase
HRE53_RS21440	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HRE53_RS21445	COG2198	Histidine kinase
HRE53_RS21445	COG2205	protein histidine kinase activity
HRE53_RS21445	COG0784	Response regulator, receiver
HRE53_RS21470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRE53_RS21515	COG2319	Wd-40 repeat
HRE53_RS21515	COG3903	Transcriptional regulator
HRE53_RS21535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRE53_RS21540	COG0515	serine threonine protein kinase
HRE53_RS21540	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS21555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS21560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRE53_RS21570	COG2135	peptidase activity
HRE53_RS21575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRE53_RS21685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRE53_RS21695	COG2197	response regulator
HRE53_RS21760	COG0586	Pfam SNARE associated Golgi protein
HRE53_RS21775	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HRE53_RS21790	COG3654	unkown
HRE53_RS21815	COG0589	response to stress
HRE53_RS21820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRE53_RS21830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_RS21840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRE53_RS21845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HRE53_RS21850	COG0572	uridine kinase
HRE53_RS21860	COG0492	ferredoxin-NADP+ reductase activity
HRE53_RS21865	COG0142	geranyltranstransferase activity
HRE53_RS21870	COG0681	Belongs to the peptidase S26 family
HRE53_RS21875	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HRE53_RS21880	COG1672	PFAM Archaeal ATPase
HRE53_RS21885	COG0824	Thioesterase
HRE53_RS21895	COG0811	peptide transport
HRE53_RS21900	COG0848	biopolymer transport protein
HRE53_RS21915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRE53_RS21915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HRE53_RS21925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRE53_RS21940	COG0271	Belongs to the BolA IbaG family
HRE53_RS21945	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HRE53_RS21950	COG3063	Type IV pilus biogenesis stability protein PilW
HRE53_RS21960	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HRE53_RS21965	COG0352	thiamine-phosphate diphosphorylase activity
HRE53_RS21990	COG3063	Type IV pilus biogenesis stability protein PilW
HRE53_RS22020	COG0793	Belongs to the peptidase S41A family
HRE53_RS22030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HRE53_RS22060	COG3706	GGDEF domain
HRE53_RS22060	COG2203	Gaf domain
HRE53_RS22060	COG4251	negative regulation of phosphorylation
HRE53_RS22060	COG5001	Diguanylate cyclase
HRE53_RS22070	COG5002	protein histidine kinase activity
HRE53_RS22070	COG5001	Diguanylate cyclase
HRE53_RS22075	COG2234	aminopeptidase activity
HRE53_RS22160	COG3266	domain, Protein
HRE53_RS22160	COG0515	serine threonine protein kinase
HRE53_RS22165	COG0631	protein serine/threonine phosphatase activity
HRE53_RS22215	COG5002	protein histidine kinase activity
HRE53_RS22250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRE53_RS22265	COG1413	lyase activity
HRE53_RS22300	COG0039	L-malate dehydrogenase activity
HRE53_RS22305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRE53_RS22325	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRE53_RS22345	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRE53_RS22355	COG1555	photosystem II stabilization
HRE53_RS22360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRE53_RS22365	COG1994	Peptidase M50
HRE53_RS22365	COG0517	IMP dehydrogenase activity
HRE53_RS22420	COG1295	ribonuclease BN
HRE53_RS22420	COG1959	2 iron, 2 sulfur cluster binding
HRE53_RS22430	COG3237	CsbD-like
HRE53_RS22440	COG3437	response regulator, receiver
HRE53_RS22465	COG5487	UPF0391 membrane protein
HRE53_RS22470	COG3237	CsbD-like
HRE53_RS22485	COG0783	Belongs to the Dps family
HRE53_RS22520	COG0259	pyridoxamine-phosphate oxidase activity
HRE53_RS22525	COG0534	Mate efflux family protein
HRE53_RS22540	COG0517	IMP dehydrogenase activity
HRE53_RS22540	COG1994	Peptidase M50
HRE53_RS22550	COG0589	response to stress
HRE53_RS22565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRE53_RS22590	COG4251	negative regulation of phosphorylation
HRE53_RS22600	COG3781	membrane
HRE53_RS22615	COG0784	Response regulator, receiver
HRE53_RS22620	COG3850	Histidine kinase
HRE53_RS22620	COG2205	protein histidine kinase activity
HRE53_RS22620	COG3437	response regulator, receiver
HRE53_RS22620	COG4999	Histidine kinase
HRE53_RS22625	COG2205	protein histidine kinase activity
HRE53_RS22625	COG0784	Response regulator, receiver
HRE53_RS22635	COG0668	transmembrane transport
HRE53_RS22645	COG3852	Histidine kinase
HRE53_RS22660	COG1090	epimerase
HRE53_RS22670	COG2226	methyltransferase
HRE53_RS22685	COG0398	Pfam SNARE associated Golgi protein
HRE53_RS22700	COG0702	epimerase
HRE53_RS22740	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRE53_RS22745	COG4191	Histidine kinase
HRE53_RS22745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_RS22760	COG1361	Conserved repeat domain
HRE53_RS22765	COG0745	RESPONSE REGULATOR receiver
HRE53_RS22775	COG1620	l-lactate permease
HRE53_RS22790	COG0676	glucose-6-phosphate 1-epimerase activity
HRE53_RS22800	COG0829	nickel cation binding
HRE53_RS22805	COG0831	urea catabolic process
HRE53_RS22815	COG0431	NADPH-dependent FMN reductase
HRE53_RS22820	COG0832	Belongs to the urease beta subunit family
HRE53_RS22825	COG0515	serine threonine protein kinase
HRE53_RS22825	COG2815	serine threonine protein kinase
HRE53_RS22835	COG5002	protein histidine kinase activity
HRE53_RS22835	COG3447	MASE1 domain protein
HRE53_RS22835	COG5001	Diguanylate cyclase
HRE53_RS22840	COG5002	protein histidine kinase activity
HRE53_RS22840	COG0784	Response regulator, receiver
HRE53_RS22840	COG2205	protein histidine kinase activity
HRE53_RS22855	COG0804	urea catabolic process
HRE53_RS22870	COG0393	Putative heavy-metal-binding
HRE53_RS22895	COG1132	(ABC) transporter
HRE53_RS22900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRE53_RS22905	COG0033	Phosphoglucomutase
HRE53_RS22910	COG2808	Putative FMN-binding domain
HRE53_RS22920	COG0617	tRNA 3'-terminal CCA addition
HRE53_RS22930	COG5433	transposase activity
HRE53_RS22950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRE53_RS22990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_RS23005	COG3118	belongs to the thioredoxin family
HRE53_RS23020	COG0517	IMP dehydrogenase activity
HRE53_RS23020	COG0516	GMP reductase activity
HRE53_RS23035	COG1480	7TM receptor with intracellular HD hydrolase
HRE53_RS23040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRE53_RS23065	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HRE53_RS23120	COG0123	including yeast histone deacetylase and acetoin utilization protein
HRE53_RS23170	COG2226	methyltransferase
HRE53_RS23180	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HRE53_RS23190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HRE53_RS23195	COG1606	tRNA processing
HRE53_RS23215	COG3550	peptidyl-serine autophosphorylation
HRE53_RS23220	COG3550	peptidyl-serine autophosphorylation
HRE53_RS23235	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS23245	COG0297	glycogen (starch) synthase activity
HRE53_RS23260	COG0489	protein tyrosine kinase activity
HRE53_RS23260	COG3206	protein involved in exopolysaccharide biosynthesis
HRE53_RS23270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRE53_RS23340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRE53_RS23350	COG2259	Doxx family
HRE53_RS23355	COG1372	Participates in initiation and elongation during chromosome replication
HRE53_RS23355	COG0305	Participates in initiation and elongation during chromosome replication
HRE53_RS23355	COG1372	Participates in initiation and elongation during chromosome replication
HRE53_RS23355	COG0305	Participates in initiation and elongation during chromosome replication
HRE53_RS23360	COG0359	binds to the 23S rRNA
HRE53_RS23420	COG1216	Glycosyl transferase, family 2
HRE53_RS23495	COG3266	domain, Protein
HRE53_RS23495	COG0515	serine threonine protein kinase
HRE53_RS23505	COG1187	pseudouridine synthase activity
HRE53_RS23510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HRE53_RS23525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRE53_RS23530	COG1799	cell septum assembly
HRE53_RS23535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRE53_RS23560	COG0596	Alpha beta hydrolase
HRE53_RS23565	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRE53_RS23570	COG0739	heme binding
HRE53_RS23590	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_RS23595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRE53_RS23600	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_RS23605	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_RS23610	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HRE53_RS23615	COG4451	ribulose bisphosphate carboxylase, small
HRE53_RS23615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRE53_RS23620	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HRE53_RS23625	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_RS23630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRE53_RS23650	COG1597	lipid kinase activity
HRE53_RS23650	COG1803	Methylglyoxal synthase
HRE53_RS23680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRE53_RS23695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRE53_RS23725	COG0583	DNA-binding transcription factor activity
HRE53_RS23740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRE53_RS23750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRE53_RS23755	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRE53_RS23785	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS23790	COG3903	Transcriptional regulator
HRE53_RS23790	COG2319	Wd-40 repeat
HRE53_RS23795	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS23795	COG0515	serine threonine protein kinase
HRE53_RS23815	COG5001	Diguanylate cyclase
HRE53_RS23815	COG3300	MHYT domain
HRE53_RS23820	COG3920	Histidine kinase
HRE53_RS23835	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS23860	COG5001	Diguanylate cyclase
HRE53_RS23865	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRE53_RS23870	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRE53_RS23890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRE53_RS23895	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HRE53_RS23900	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRE53_RS23910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRE53_RS23920	COG0483	inositol monophosphate 1-phosphatase activity
HRE53_RS23930	COG3273	potassium ion transport
HRE53_RS23930	COG0471	metal ion transport
HRE53_RS23935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRE53_RS23940	COG0798	PFAM Bile acid sodium symporter
HRE53_RS23945	COG0789	Transcriptional regulator
HRE53_RS23950	COG0751	glycine-tRNA ligase activity
HRE53_RS23955	COG0612	Peptidase, M16
HRE53_RS23965	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRE53_RS23970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRE53_RS23975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HRE53_RS23980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HRE53_RS23990	COG2124	cytochrome p450
HRE53_RS23995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRE53_RS23995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRE53_RS24000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRE53_RS24025	COG0408	coproporphyrinogen oxidase activity
HRE53_RS24030	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HRE53_RS24045	COG0501	Belongs to the peptidase M48B family
HRE53_RS24065	COG0739	heme binding
HRE53_RS24070	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HRE53_RS24070	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HRE53_RS24075	COG1496	oxidoreductase activity
HRE53_RS24105	COG1741	Belongs to the pirin family
HRE53_RS24115	COG2205	protein histidine kinase activity
HRE53_RS24115	COG0784	Response regulator, receiver
HRE53_RS24120	COG0589	response to stress
HRE53_RS24125	COG0126	phosphoglycerate kinase activity
HRE53_RS24140	COG0124	histidyl-tRNA synthetase
HRE53_RS24160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRE53_RS24165	COG0577	efflux transmembrane transporter activity
HRE53_RS24165	COG1136	(ABC) transporter
HRE53_RS24170	COG1136	(ABC) transporter
HRE53_RS24190	COG5001	Diguanylate cyclase
HRE53_RS24195	COG0517	IMP dehydrogenase activity
HRE53_RS24195	COG1994	Peptidase M50
HRE53_RS24200	COG0095	Lipoate-protein ligase
HRE53_RS24215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRE53_RS24220	COG0189	ligase activity
HRE53_RS24225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRE53_RS24260	COG4279	zinc finger
HRE53_RS24270	COG3328	transposase activity
HRE53_RS24290	COG1215	transferase activity, transferring glycosyl groups
HRE53_RS24320	COG0514	ATP-dependent DNA helicase (RecQ)
HRE53_RS24335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_RS24350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRE53_RS24360	COG5002	protein histidine kinase activity
HRE53_RS24360	COG5001	Diguanylate cyclase
HRE53_RS24365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_RS24385	COG0628	permease
HRE53_RS24395	COG0003	Pfam Anion-transporting ATPase
HRE53_RS24400	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_RS24405	COG0825	malonyl-CoA metabolic process
HRE53_RS24410	COG0300	oxidoreductase activity
HRE53_RS24415	COG0302	gtp cyclohydrolase
HRE53_RS24430	COG0784	Response regulator, receiver
HRE53_RS24430	COG2198	Histidine kinase
HRE53_RS24430	COG5002	protein histidine kinase activity
HRE53_RS24460	COG0418	dihydroorotase activity
HRE53_RS24470	COG2994	toxin metabolic process
HRE53_RS24545	COG2201	protein-glutamate methylesterase activity
HRE53_RS24550	COG5002	protein histidine kinase activity
HRE53_RS24550	COG2198	Histidine kinase
HRE53_RS24550	COG0784	Response regulator, receiver
HRE53_RS24585	COG2204	response regulator
HRE53_RS24625	COG2205	protein histidine kinase activity
HRE53_RS24625	COG0784	Response regulator, receiver
HRE53_RS24625	COG5002	protein histidine kinase activity
HRE53_RS24630	COG0121	glutamine amidotransferase
HRE53_RS24640	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HRE53_RS24645	COG0443	Heat shock 70 kDa protein
HRE53_RS24650	COG0484	heat shock protein binding
HRE53_RS24655	COG1704	LemA family
HRE53_RS24675	COG3046	protein related to deoxyribodipyrimidine photolyase
HRE53_RS24695	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS24695	COG0515	serine threonine protein kinase
HRE53_RS24700	COG0515	serine threonine protein kinase
HRE53_RS24710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRE53_RS24715	COG0546	phosphoglycolate phosphatase activity
HRE53_RS24720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRE53_RS24775	COG4178	(ABC) transporter
HRE53_RS24785	COG0483	inositol monophosphate 1-phosphatase activity
HRE53_RS24810	COG1160	GTP binding
HRE53_RS24825	COG0515	serine threonine protein kinase
HRE53_RS24825	COG3266	domain, Protein
HRE53_RS24845	COG0326	Molecular chaperone. Has ATPase activity
HRE53_RS24850	COG4251	negative regulation of phosphorylation
HRE53_RS24860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HRE53_RS24865	COG1185	polyribonucleotide nucleotidyltransferase activity
HRE53_RS24870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRE53_RS24935	COG0776	regulation of translation
HRE53_RS24940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRE53_RS24950	COG0435	Glutathione S-transferase
HRE53_RS24955	COG1950	PFAM Membrane protein of
HRE53_RS24965	COG0697	spore germination
HRE53_RS24970	COG1846	Transcriptional regulator
HRE53_RS24975	COG4251	negative regulation of phosphorylation
HRE53_RS24980	COG0784	Response regulator, receiver
HRE53_RS24990	COG4251	negative regulation of phosphorylation
HRE53_RS25015	COG0659	secondary active sulfate transmembrane transporter activity
HRE53_RS25060	COG2273	Hydrolase Family 16
HRE53_RS25060	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRE53_RS25065	COG5002	protein histidine kinase activity
HRE53_RS25075	COG0523	cobalamin synthesis protein
HRE53_RS25085	COG1032	radical SAM domain protein
HRE53_RS25095	COG3394	polysaccharide catabolic process
HRE53_RS25110	COG0107	imidazoleglycerol-phosphate synthase activity
HRE53_RS25120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRE53_RS25125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRE53_RS25135	COG0488	(ABC) transporter
HRE53_RS25140	COG1801	Protein of unknown function DUF72
HRE53_RS25145	COG0515	serine threonine protein kinase
HRE53_RS25160	COG2124	cytochrome p450
HRE53_RS25165	COG0138	bifunctional purine biosynthesis protein purh
HRE53_RS25170	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_RS25175	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HRE53_RS25180	COG0673	inositol 2-dehydrogenase activity
HRE53_RS25185	COG0367	asparagine synthase
HRE53_RS25200	COG2226	methyltransferase
HRE53_RS25230	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS25230	COG1216	Glycosyl transferase, family 2
HRE53_RS25235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HRE53_RS25240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HRE53_RS25245	COG1494	fructose-1,6-bisphosphatase
HRE53_RS25255	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS25255	COG0515	serine threonine protein kinase
HRE53_RS25265	COG0473	3-isopropylmalate dehydrogenase activity
HRE53_RS25275	COG1131	(ABC) transporter
HRE53_RS25285	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HRE53_RS25290	COG2385	sporulation resulting in formation of a cellular spore
HRE53_RS25310	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HRE53_RS25310	COG0662	Cupin 2, conserved barrel domain protein
HRE53_RS25315	COG0316	Belongs to the HesB IscA family
HRE53_RS25340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRE53_RS25350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRE53_RS25370	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS25375	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS25380	COG0489	protein tyrosine kinase activity
HRE53_RS25405	COG1216	Glycosyl transferase, family 2
HRE53_RS25405	COG0463	Glycosyl transferase, family 2
HRE53_RS25410	COG1132	(ABC) transporter
HRE53_RS25485	COG5002	protein histidine kinase activity
HRE53_RS25485	COG0784	Response regulator, receiver
HRE53_RS25515	COG0716	FMN binding
HRE53_RS25520	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HRE53_RS25525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_RS25530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRE53_RS25535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRE53_RS25555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRE53_RS25565	COG2133	pyrroloquinoline quinone binding
HRE53_RS25575	COG1271	oxidase subunit
HRE53_RS25620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRE53_RS25660	COG0405	Gamma-glutamyltransferase
HRE53_RS25670	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRE53_RS25680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRE53_RS25690	COG0438	transferase activity, transferring glycosyl groups
HRE53_RS25715	COG0004	ammonium transporteR
HRE53_RS25745	COG3706	GGDEF domain
HRE53_RS25750	COG2988	succinylglutamate desuccinylase activity
HRE53_RS25765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRE53_RS25765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRE53_RS25805	COG0515	serine threonine protein kinase
HRE53_RS25805	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS25810	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_RS25815	COG0306	phosphate transporter
HRE53_RS25830	COG0784	Response regulator, receiver
HRE53_RS25830	COG3437	response regulator, receiver
HRE53_RS25840	COG3279	Response regulator of the LytR AlgR family
HRE53_RS25845	COG2198	Histidine kinase
HRE53_RS25845	COG5002	protein histidine kinase activity
HRE53_RS25845	COG0784	Response regulator, receiver
HRE53_RS25865	COG0493	'glutamate synthase
HRE53_RS25885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HRE53_RS25910	COG0189	ligase activity
HRE53_RS25915	COG0697	spore germination
HRE53_RS25935	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HRE53_RS25940	COG1254	Belongs to the acylphosphatase family
HRE53_RS25945	COG0745	RESPONSE REGULATOR receiver
HRE53_RS25955	COG3328	transposase activity
HRE53_RS25975	COG5002	protein histidine kinase activity
HRE53_RS25995	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_RS26005	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HRE53_RS26125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRE53_RS26150	COG0410	ABC transporter
HRE53_RS26190	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_RS26255	COG3328	transposase activity
HRE53_RS26290	COG4191	Histidine kinase
HRE53_RS26305	COG0784	Response regulator, receiver
HRE53_RS26305	COG2205	protein histidine kinase activity
HRE53_RS26310	COG3903	Transcriptional regulator
HRE53_RS26310	COG2319	Wd-40 repeat
HRE53_RS26315	COG0644	oxidoreductase
HRE53_RS26340	COG2197	response regulator
HRE53_RS26345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRE53_RS26345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HRE53_RS26365	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HRE53_RS26370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRE53_RS26375	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HRE53_RS26390	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HRE53_RS26400	COG0367	asparagine synthase
HRE53_RS26410	COG2066	Belongs to the glutaminase family
HRE53_RS26415	COG1125	glycine betaine transport
HRE53_RS26415	COG0517	IMP dehydrogenase activity
HRE53_RS26435	COG1484	DNA-dependent DNA replication
HRE53_RS26465	COG5433	transposase activity
HRE53_RS26565	COG3335	DDE superfamily endonuclease
HRE53_RS26620	COG0484	heat shock protein binding
HRE53_RS26625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRE53_RS26640	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HRE53_RS26800	COG2375	cellular response to nickel ion
HRE53_RS26825	COG0784	Response regulator, receiver
HRE53_RS26845	COG5002	protein histidine kinase activity
HRE53_RS26845	COG5001	Diguanylate cyclase
HRE53_RS26845	COG3447	MASE1 domain protein
HRE53_RS26870	COG5001	Diguanylate cyclase
HRE53_RS26870	COG3300	MHYT domain
HRE53_RS26875	COG3920	Histidine kinase
HRE53_RS26895	COG2205	protein histidine kinase activity
HRE53_RS26895	COG4999	Histidine kinase
HRE53_RS26895	COG3437	response regulator, receiver
HRE53_RS26895	COG3850	Histidine kinase
HRE53_RS26905	COG3437	response regulator, receiver
HRE53_RS26935	COG2205	protein histidine kinase activity
HRE53_RS26940	COG5001	Diguanylate cyclase
HRE53_RS26940	COG1716	ATPase activity
HRE53_RS26950	COG2203	Gaf domain
HRE53_RS26950	COG3706	GGDEF domain
HRE53_RS26950	COG5001	Diguanylate cyclase
HRE53_RS26950	COG4251	negative regulation of phosphorylation
HRE53_RS26965	COG5002	protein histidine kinase activity
HRE53_RS26965	COG5001	Diguanylate cyclase
HRE53_RS27065	COG0724	RNA recognition motif
HRE53_RS27085	COG0745	RESPONSE REGULATOR receiver
HRE53_RS27100	COG0724	RNA recognition motif
HRE53_RS27150	COG0515	serine threonine protein kinase
HRE53_RS27185	COG2205	protein histidine kinase activity
HRE53_RS27185	COG3437	response regulator, receiver
HRE53_RS27185	COG3850	Histidine kinase
HRE53_RS27185	COG4999	Histidine kinase
HRE53_RS27215	COG1484	DNA-dependent DNA replication
HRE53_RS27220	COG0784	Response regulator, receiver
HRE53_RS27240	COG3920	Histidine kinase
HRE53_RS27260	COG3437	response regulator, receiver
HRE53_RS27275	COG1716	ATPase activity
HRE53_RS27275	COG5001	Diguanylate cyclase
HRE53_RS27280	COG5001	Diguanylate cyclase
HRE53_RS27280	COG4251	negative regulation of phosphorylation
HRE53_RS27280	COG3706	GGDEF domain
HRE53_RS27280	COG2203	Gaf domain
HRE53_RS27290	COG5002	protein histidine kinase activity
HRE53_RS27290	COG5001	Diguanylate cyclase
HRE53_RS27295	COG5001	Diguanylate cyclase
HRE53_RS27295	COG5002	protein histidine kinase activity
HRE53_RS27310	COG0347	Belongs to the P(II) protein family
HRE53_RS27315	COG0475	glutathione-regulated potassium exporter activity
HRE53_RS27320	COG1006	Multisubunit Na H antiporter MnhC subunit
HRE53_RS27325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRE53_RS27370	COG0583	DNA-binding transcription factor activity
HRE53_RS27385	COG4584	PFAM Integrase catalytic
HRE53_RS27390	COG1484	DNA-dependent DNA replication
HRE53_RS27445	COG4974	Belongs to the 'phage' integrase family
HRE53_RS27450	COG4974	Belongs to the 'phage' integrase family
HRE53_RS27500	COG1484	DNA-dependent DNA replication
HRE53_RS27510	COG1309	transcriptional regulator
HRE53_RS27535	COG2814	Major facilitator Superfamily
HRE53_RS27540	COG1028	Short-chain dehydrogenase reductase Sdr
HRE53_RS27545	COG1169	isochorismate synthase
HRE53_RS27550	COG1021	2,3-dihydroxybenzoate-AMP ligase
HRE53_RS27555	COG3433	isochorismatase activity
HRE53_RS27555	COG1535	isochorismatase
HRE53_RS27560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRE53_RS27560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HRE53_RS27585	COG3335	DDE superfamily endonuclease
HRE53_RS27635	COG4974	Belongs to the 'phage' integrase family
HRE53_RS27670	COG2197	response regulator
HRE53_RS27675	COG0784	Response regulator, receiver
HRE53_RS27675	COG2205	protein histidine kinase activity
HRE53_RS27680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HRE53_RS27685	COG5002	protein histidine kinase activity
HRE53_RS27690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS27705	COG0589	response to stress
HRE53_RS27705	COG0475	glutathione-regulated potassium exporter activity
HRE53_RS27725	COG0189	ligase activity
HRE53_RS27730	COG4067	protein conserved in archaea
HRE53_RS27730	COG0189	ligase activity
HRE53_RS27755	COG1077	Cell shape determining protein MreB Mrl
HRE53_RS27795	COG0572	uridine kinase
HRE53_RS27805	COG1475	DNA binding
HRE53_RS27835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRE53_RS27970	COG0776	regulation of translation
HRE53_RS27990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS28010	COG0187	DNA topoisomerase II activity
HRE53_RS28010	COG1372	Participates in initiation and elongation during chromosome replication
HRE53_RS28090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRE53_RS28225	COG0739	heme binding
HRE53_RS28305	COG1484	DNA-dependent DNA replication
HRE53_RS28315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS28365	COG1484	DNA-dependent DNA replication
HRE53_RS28410	COG0724	RNA recognition motif
HRE53_RS28420	COG1484	DNA-dependent DNA replication
HRE53_RS28440	COG0589	response to stress
HRE53_RS28455	COG0702	epimerase
HRE53_RS28475	COG2226	methyltransferase
HRE53_RS28480	COG0693	protein deglycase activity
HRE53_RS28560	COG4584	PFAM Integrase catalytic
HRE53_RS28580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRE53_RS28585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRE53_RS28585	COG3453	Protein conserved in bacteria
HRE53_RS28600	COG1475	DNA binding
HRE53_RS28605	COG1192	Involved in chromosome partitioning
HRE53_RS28650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRE53_RS28710	COG0589	response to stress
HRE53_RS28735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRE53_RS28745	COG0726	polysaccharide deacetylase
HRE53_RS28765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRE53_RS28825	COG4584	PFAM Integrase catalytic
HRE53_RS28830	COG2390	Transcriptional regulator
HRE53_RS28830	COG4584	PFAM Integrase catalytic
HRE53_RS28890	COG2815	serine threonine protein kinase
HRE53_RS28890	COG0515	serine threonine protein kinase
HRE53_RS28965	COG2124	cytochrome p450
HRE53_RS28990	COG1799	cell septum assembly
HRE53_RS29010	COG0724	RNA recognition motif
HRE53_RS29030	COG0745	RESPONSE REGULATOR receiver
HRE53_RS29075	COG1484	DNA-dependent DNA replication
HRE53_RS29085	COG1484	DNA-dependent DNA replication
HRE53_RS29130	COG0745	RESPONSE REGULATOR receiver
HRE53_RS29140	COG0724	RNA recognition motif
HRE53_RS29215	COG1555	photosystem II stabilization
HRE53_RS29240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRE53_RS29260	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HRE53_RS29275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRE53_RS29280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRE53_RS29295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRE53_RS29305	COG0484	heat shock protein binding
HRE53_RS29355	COG1484	DNA-dependent DNA replication
HRE53_RS29375	COG5002	protein histidine kinase activity
HRE53_RS29425	COG1077	Cell shape determining protein MreB Mrl
HRE53_RS29435	COG0205	6-phosphofructokinase activity
HRE53_RS29440	COG0409	Hydrogenase expression formation protein
HRE53_RS29450	COG1960	acyl-CoA dehydrogenase activity
HRE53_RS29455	COG0183	Belongs to the thiolase family
HRE53_RS29475	COG2267	carboxylic ester hydrolase activity
HRE53_RS29480	COG0071	Belongs to the small heat shock protein (HSP20) family
HRE53_RS29525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRE53_RS29525	COG2205	protein histidine kinase activity
HRE53_RS29530	COG4251	negative regulation of phosphorylation
HRE53_RS29535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRE53_RS29535	COG0574	Belongs to the PEP-utilizing enzyme family
HRE53_RS29555	COG0475	glutathione-regulated potassium exporter activity
HRE53_RS29585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRE53_RS29620	COG0589	response to stress
HRE53_RS29625	COG0589	response to stress
HRE53_RS29650	COG1034	ATP synthesis coupled electron transport
HRE53_RS29655	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRE53_RS29660	COG0517	IMP dehydrogenase activity
HRE53_RS29680	COG3259	Nickel-dependent hydrogenase
HRE53_RS29685	COG0298	carbon dioxide binding
HRE53_RS29710	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRE53_RS29715	COG0375	protein maturation
HRE53_RS29735	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HRE53_RS29750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS29775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRE53_RS29820	COG1484	DNA-dependent DNA replication
HRE53_RS29840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRE53_RS29850	COG0569	domain protein
HRE53_RS29855	COG2204	response regulator
HRE53_RS29860	COG5002	protein histidine kinase activity
HRE53_RS29890	COG5002	protein histidine kinase activity
HRE53_RS29925	COG3437	response regulator, receiver
HRE53_RS29930	COG0784	Response regulator, receiver
HRE53_RS29930	COG2205	protein histidine kinase activity
HRE53_RS29990	COG0058	SHG alpha-glucan phosphorylase activity
HRE53_RS30010	COG2205	protein histidine kinase activity
HRE53_RS30010	COG2198	Histidine kinase
HRE53_RS30010	COG0784	Response regulator, receiver
HRE53_RS30020	COG3093	addiction module antidote protein HigA
HRE53_RS30060	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRE53_RS30060	COG2273	Hydrolase Family 16
HRE53_RS30065	COG5002	protein histidine kinase activity
HRE53_RS30070	COG0745	RESPONSE REGULATOR receiver
HRE53_RS30095	COG5002	protein histidine kinase activity
HRE53_RS30105	COG0789	Transcriptional regulator
HRE53_RS30130	COG4974	Belongs to the 'phage' integrase family
HRE53_RS30145	COG1192	Involved in chromosome partitioning
HRE53_RS30150	COG1475	DNA binding
HRE53_RS30320	COG0776	regulation of translation
HRE53_RS30335	COG1366	Belongs to the anti-sigma-factor antagonist family
HRE53_RS30360	COG0776	regulation of translation
HRE53_RS30370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS30465	COG0739	heme binding
HRE53_RS30580	COG2226	methyltransferase
HRE53_RS30590	COG0724	RNA recognition motif
HRE53_RS30635	COG0484	heat shock protein binding
HRE53_RS30640	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRE53_RS30660	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HRE53_RS30665	COG0745	RESPONSE REGULATOR receiver
HRE53_RS30715	COG4572	Cation transport regulator
HRE53_RS30740	COG0557	exoribonuclease II activity
HRE53_RS30775	COG2319	Wd-40 repeat
HRE53_RS30780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HRE53_RS30790	COG4974	Belongs to the 'phage' integrase family
HRE53_RS30795	COG2319	Wd-40 repeat
HRE53_RS30795	COG4249	Peptidase C14 caspase catalytic subunit p20
HRE53_RS30825	COG2319	Wd-40 repeat
HRE53_RS30825	COG4249	Peptidase C14 caspase catalytic subunit p20
HRE53_RS30850	COG1672	PFAM Archaeal ATPase
HRE53_RS30850	COG2319	Wd-40 repeat
HRE53_RS30870	COG4974	Belongs to the 'phage' integrase family
HRE53_RS30875	COG2319	Wd-40 repeat
HRE53_RS30875	COG4249	Peptidase C14 caspase catalytic subunit p20
HRE53_RS30940	COG0629	single-stranded DNA binding
HRE53_RS31025	COG4974	Belongs to the 'phage' integrase family
HRE53_RS31155	COG3093	addiction module antidote protein HigA
HRE53_RS31165	COG3629	intracellular signal transduction
HRE53_RS31165	COG3903	Transcriptional regulator
HRE53_RS31190	COG4227	nucleotidyltransferase activity
HRE53_RS31205	COG1484	DNA-dependent DNA replication
HRE53_RS31210	COG4584	PFAM Integrase catalytic
HRE53_RS31210	COG2390	Transcriptional regulator
HRE53_RS31225	COG3093	addiction module antidote protein HigA
HRE53_RS31275	COG3629	intracellular signal transduction
HRE53_RS31275	COG3903	Transcriptional regulator
HRE53_RS31285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRE53_RS31300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRE53_RS31355	COG0739	heme binding
HRE53_RS31425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS31450	COG2815	serine threonine protein kinase
HRE53_RS31450	COG0515	serine threonine protein kinase
HRE53_RS31515	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HRE53_RS31535	COG1475	DNA binding
HRE53_RS31630	COG3328	transposase activity
HRE53_RS31645	COG3093	addiction module antidote protein HigA
HRE53_RS31705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HRE53_RS31870	COG0515	serine threonine protein kinase
HRE53_RS31870	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS31950	COG1401	restriction endodeoxyribonuclease activity
HRE53_RS31965	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HRE53_RS31975	COG4804	nuclease activity
HRE53_RS32015	COG1476	TRANSCRIPTIONal
HRE53_RS32095	COG1484	DNA-dependent DNA replication
HRE53_RS32140	COG1192	Involved in chromosome partitioning
HRE53_RS32145	COG1475	DNA binding
HRE53_RS32165	COG1525	nuclease
HRE53_RS32215	COG2815	serine threonine protein kinase
HRE53_RS32215	COG0515	serine threonine protein kinase
HRE53_RS32395	COG3093	addiction module antidote protein HigA
HRE53_RS32450	COG1078	dGTPase activity
HRE53_RS32470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS32475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_RS32480	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRE53_RS32505	COG2329	Antibiotic biosynthesis monooxygenase
HRE53_RS32510	COG1309	transcriptional regulator
HRE53_RS32545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HRE53_RS32645	COG1799	cell septum assembly
HRE53_RS32655	COG0724	RNA recognition motif
HRE53_RS32660	COG0724	RNA recognition motif
HRE53_RS32665	COG0542	response to heat
HRE53_RS32675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS32820	COG0739	heme binding
HRE53_RS32895	COG0515	serine threonine protein kinase
HRE53_RS32895	COG1357	PFAM Pentapeptide repeats (8 copies)
HRE53_RS32945	COG3093	addiction module antidote protein HigA
HRE53_RS33025	COG4584	PFAM Integrase catalytic
HRE53_RS33030	COG4584	PFAM Integrase catalytic
HRE53_RS33030	COG2390	Transcriptional regulator
HRE53_RS33035	COG1484	DNA-dependent DNA replication
HRE53_RS33095	COG3328	transposase activity
HRE53_RS33130	COG3328	transposase activity
HRE53_RS33140	COG1484	DNA-dependent DNA replication
HRE53_RS33150	COG2201	protein-glutamate methylesterase activity
HRE53_RS33185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRE53_RS33195	COG0557	exoribonuclease II activity
HRE53_RS33270	COG2226	methyltransferase
HRE53_RS33280	COG1476	TRANSCRIPTIONal
HRE53_RS33295	COG5433	transposase activity
HRE53_RS33460	COG1475	DNA binding
HRE53_RS33505	COG3903	Transcriptional regulator
HRE53_RS33505	COG2319	Wd-40 repeat
HRE53_RS33510	COG3903	Transcriptional regulator
HRE53_RS33510	COG2319	Wd-40 repeat
HRE53_RS33515	COG3903	Transcriptional regulator
HRE53_RS33515	COG2319	Wd-40 repeat
HRE53_RS33570	COG0724	RNA recognition motif
HRE53_RS33620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRE53_RS33635	COG3629	intracellular signal transduction
HRE53_RS33635	COG3903	Transcriptional regulator
HRE53_RS33835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRE53_RS33890	COG0515	serine threonine protein kinase
HRE53_RS33905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRE53_RS34000	COG0739	heme binding
HRE53_RS34080	COG1192	Involved in chromosome partitioning
HRE53_RS34175	COG1404	Belongs to the peptidase S8 family
HRE53_RS34185	COG1404	Belongs to the peptidase S8 family
HRE53_RS34230	COG3328	transposase activity
HRE53_RS34385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRE53_RS34400	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HRE53_RS34425	COG0730	response to heat
HRE53_RS34440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HRE53_RS34445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HRE53_RS34470	COG0612	Peptidase, M16
HRE53_RS34475	COG0612	Peptidase, M16
HRE53_RS34500	COG0270	DNA (cytosine-5-)-methyltransferase activity
HRE53_RS34520	COG0786	glutamate:sodium symporter activity
HRE53_RS34550	COG2204	response regulator
HRE53_RS34555	COG3634	alkyl hydroperoxide reductase activity
HRE53_RS34600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRE53_RS34635	COG2199	diguanylate cyclase activity
HRE53_RS34635	COG2200	EAL domain
HRE53_RS34635	COG2203	Gaf domain
HRE53_RS34685	COG2423	ornithine cyclodeaminase activity
HRE53_RS34710	COG0318	PFAM AMP-dependent synthetase and ligase
HRE53_RS34715	COG0318	PFAM AMP-dependent synthetase and ligase