locus-tag	class	description
CTHE_RS00070	COG3507	Belongs to the glycosyl hydrolase 43 family
CTHE_RS00095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTHE_RS00100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CTHE_RS00105	COG0156	8-amino-7-oxononanoate synthase activity
CTHE_RS00110	COG2267	carboxylic ester hydrolase activity
CTHE_RS00115	COG4106	trans-aconitate 2-methyltransferase activity
CTHE_RS00125	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CTHE_RS00170	COG4124	Belongs to the glycosyl hydrolase 26 family
CTHE_RS00190	COG1151	hydroxylamine reductase activity
CTHE_RS00205	COG0840	transmembrane signaling receptor activity
CTHE_RS00210	COG4733	cellulase activity
CTHE_RS00210	COG4447	cellulose binding
CTHE_RS00220	COG1160	GTP binding
CTHE_RS00225	COG4447	cellulose binding
CTHE_RS00225	COG4733	cellulase activity
CTHE_RS00230	COG2382	esterase
CTHE_RS00230	COG3507	Belongs to the glycosyl hydrolase 43 family
CTHE_RS00230	COG3693	PFAM glycoside hydrolase, family 10
CTHE_RS00275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CTHE_RS00280	COG1649	PFAM Uncharacterised BCR, COG1649
CTHE_RS00305	COG1191	sigma factor activity
CTHE_RS00310	COG4447	cellulose binding
CTHE_RS00315	COG0653	protein targeting
CTHE_RS00320	COG1268	BioY protein
CTHE_RS00325	COG1368	sulfuric ester hydrolase activity
CTHE_RS00335	COG1283	sodium-dependent phosphate transmembrane transporter activity
CTHE_RS00355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CTHE_RS00360	COG2502	aspartate--ammonia ligase
CTHE_RS00365	COG0017	Asparaginyl-tRNA synthetase
CTHE_RS00370	COG4447	cellulose binding
CTHE_RS00370	COG5297	Belongs to the glycosyl hydrolase family 6
CTHE_RS00415	COG0835	chemotaxis
CTHE_RS00420	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CTHE_RS00425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CTHE_RS00450	COG0424	maF-like protein
CTHE_RS00455	COG1077	Cell shape determining protein MreB Mrl
CTHE_RS00470	COG0768	penicillin binding
CTHE_RS00475	COG0850	regulation of cytokinetic process
CTHE_RS00480	COG2894	cell division
CTHE_RS00485	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CTHE_RS00490	COG1803	Methylglyoxal synthase
CTHE_RS00500	COG0739	heme binding
CTHE_RS00505	COG1994	Peptidase M50
CTHE_RS00505	COG0517	IMP dehydrogenase activity
CTHE_RS00510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CTHE_RS00520	COG1979	alcohol dehydrogenase
CTHE_RS00525	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CTHE_RS00530	COG0432	Pfam Uncharacterised protein family UPF0047
CTHE_RS00550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CTHE_RS00575	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CTHE_RS00580	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CTHE_RS00585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CTHE_RS00590	COG1660	Displays ATPase and GTPase activities
CTHE_RS00595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CTHE_RS00605	COG1481	regulation of sporulation
CTHE_RS00610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTHE_RS00615	COG1366	Belongs to the anti-sigma-factor antagonist family
CTHE_RS00675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CTHE_RS00680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTHE_RS00685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CTHE_RS00690	COG0318	PFAM AMP-dependent synthetase and ligase
CTHE_RS00715	COG0126	phosphoglycerate kinase activity
CTHE_RS00720	COG0149	triose-phosphate isomerase activity
CTHE_RS00725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CTHE_RS00735	COG2199	diguanylate cyclase activity
CTHE_RS00735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTHE_RS00740	COG0148	phosphopyruvate hydratase activity
CTHE_RS00755	COG0557	exoribonuclease II activity
CTHE_RS00760	COG1683	Conserved Protein
CTHE_RS00765	COG3328	transposase activity
CTHE_RS00775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTHE_RS00780	COG4472	Bacterial protein of unknown function (DUF965)
CTHE_RS00785	COG0667	Aldo Keto reductase
CTHE_RS00790	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CTHE_RS00795	COG3906	Belongs to the UPF0473 family
CTHE_RS00800	COG1470	cell adhesion involved in biofilm formation
CTHE_RS00825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CTHE_RS00835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CTHE_RS00840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CTHE_RS00850	COG1534	Rna-binding protein
CTHE_RS00860	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CTHE_RS00865	COG2201	protein-glutamate methylesterase activity
CTHE_RS00895	COG0493	'glutamate synthase
CTHE_RS00895	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CTHE_RS00900	COG1368	sulfuric ester hydrolase activity
CTHE_RS00920	COG0165	Argininosuccinate lyase
CTHE_RS00925	COG0137	argininosuccinate synthase activity
CTHE_RS00930	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CTHE_RS00935	COG0632	four-way junction helicase activity
CTHE_RS00940	COG2255	four-way junction helicase activity
CTHE_RS00945	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CTHE_RS00955	COG0860	N-Acetylmuramoyl-L-alanine amidase
CTHE_RS00960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CTHE_RS00965	COG5401	PFAM Sporulation and spore germination
CTHE_RS00970	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CTHE_RS00975	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CTHE_RS00980	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CTHE_RS00985	COG2273	Hydrolase Family 16
CTHE_RS01005	COG0475	glutathione-regulated potassium exporter activity
CTHE_RS01025	COG0067	glutamate synthase
CTHE_RS01030	COG0069	glutamate synthase activity
CTHE_RS01035	COG0493	'glutamate synthase
CTHE_RS01035	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CTHE_RS01040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTHE_RS01080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTHE_RS01080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CTHE_RS01085	COG1215	transferase activity, transferring glycosyl groups
CTHE_RS01090	COG1609	Transcriptional regulator
CTHE_RS01095	COG2273	Hydrolase Family 16
CTHE_RS01105	COG2723	6-phospho-beta-galactosidase activity
CTHE_RS01115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CTHE_RS01120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTHE_RS01120	COG0072	phenylalanine-tRNA ligase activity
CTHE_RS01130	COG0166	Belongs to the GPI family
CTHE_RS01135	COG1408	metallophosphoesterase
CTHE_RS01165	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CTHE_RS01210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CTHE_RS01220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CTHE_RS01225	COG0318	PFAM AMP-dependent synthetase and ligase
CTHE_RS01235	COG0667	Aldo Keto reductase
CTHE_RS01250	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CTHE_RS01270	COG3409	Peptidoglycan-binding domain 1 protein
CTHE_RS01270	COG3773	Cell wall hydrolase
CTHE_RS01275	COG2217	Heavy metal translocating P-type atpase
CTHE_RS01285	COG3401	FG-GAP repeat protein
CTHE_RS01290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTHE_RS01305	COG1690	Belongs to the RtcB family
CTHE_RS01320	COG0714	Associated with various cellular activities
CTHE_RS01335	COG1609	Transcriptional regulator
CTHE_RS01345	COG4447	cellulose binding
CTHE_RS01355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTHE_RS01365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CTHE_RS01380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CTHE_RS01385	COG0840	transmembrane signaling receptor activity
CTHE_RS01390	COG4447	cellulose binding
CTHE_RS01395	COG1191	sigma factor activity
CTHE_RS01400	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CTHE_RS01410	COG4447	cellulose binding
CTHE_RS01410	COG4733	cellulase activity
CTHE_RS01415	COG1686	Belongs to the peptidase S11 family
CTHE_RS01420	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTHE_RS01420	COG2199	diguanylate cyclase activity
CTHE_RS01425	COG4733	cellulase activity
CTHE_RS01425	COG4447	cellulose binding
CTHE_RS01430	COG3459	Glycosyltransferase 36 associated
CTHE_RS01435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTHE_RS01440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CTHE_RS01440	COG0116	Belongs to the methyltransferase superfamily
CTHE_RS01445	COG0564	pseudouridine synthase activity
CTHE_RS01460	COG0297	glycogen (starch) synthase activity
CTHE_RS01465	COG0667	Aldo Keto reductase
CTHE_RS01475	COG0538	isocitrate dehydrogenase activity
CTHE_RS01480	COG2205	protein histidine kinase activity
CTHE_RS01485	COG0784	Response regulator, receiver
CTHE_RS01485	COG2205	protein histidine kinase activity
CTHE_RS01490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CTHE_RS01495	COG1199	ATP-dependent helicase activity
CTHE_RS01500	COG0460	homoserine dehydrogenase
CTHE_RS01505	COG1331	Highly conserved protein containing a thioredoxin domain
CTHE_RS01510	COG3328	transposase activity
CTHE_RS01545	COG0840	transmembrane signaling receptor activity
CTHE_RS01550	COG0534	Mate efflux family protein
CTHE_RS01555	COG2340	Cysteine-rich secretory protein family
CTHE_RS01560	COG2966	Psort location CytoplasmicMembrane, score
CTHE_RS01585	COG0187	DNA topoisomerase II activity
CTHE_RS01590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CTHE_RS01605	COG0556	nucleotide-excision repair
CTHE_RS01610	COG3583	domain protein
CTHE_RS01610	COG3584	3D domain protein
CTHE_RS01620	COG0542	response to heat
CTHE_RS01635	COG1191	sigma factor activity
CTHE_RS01640	COG2133	pyrroloquinoline quinone binding
CTHE_RS01640	COG5183	chlorophyll binding
CTHE_RS01650	COG1376	ErfK ybiS ycfS ynhG family protein
CTHE_RS01670	COG1472	Belongs to the glycosyl hydrolase 3 family
CTHE_RS01680	COG0525	valine-tRNA ligase activity
CTHE_RS01685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CTHE_RS01685	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CTHE_RS01710	COG3266	domain, Protein
CTHE_RS01710	COG2911	Protein conserved in bacteria
CTHE_RS01710	COG1361	Conserved repeat domain
CTHE_RS01715	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CTHE_RS01740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CTHE_RS01775	COG0784	Response regulator, receiver
CTHE_RS01775	COG2205	protein histidine kinase activity
CTHE_RS01800	COG0281	malic enzyme
CTHE_RS01805	COG0039	L-malate dehydrogenase activity
CTHE_RS01815	COG0205	6-phosphofructokinase activity
CTHE_RS01825	COG0191	fructose-bisphosphate aldolase activity
CTHE_RS01830	COG0681	Belongs to the peptidase S26 family
CTHE_RS01835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CTHE_RS01850	COG1924	4 iron, 4 sulfur cluster binding
CTHE_RS01855	COG1379	DNA repair
CTHE_RS01860	COG3328	transposase activity
CTHE_RS01880	COG3118	belongs to the thioredoxin family
CTHE_RS01890	COG1522	sequence-specific DNA binding
CTHE_RS01895	COG0436	Aminotransferase
CTHE_RS01905	COG3620	sequence-specific DNA binding
CTHE_RS01920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CTHE_RS01925	COG1691	(AIR) carboxylase
CTHE_RS01930	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CTHE_RS01940	COG3328	transposase activity
CTHE_RS01955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CTHE_RS01960	COG0519	Catalyzes the synthesis of GMP from XMP
CTHE_RS02005	COG1136	(ABC) transporter
CTHE_RS02005	COG0577	efflux transmembrane transporter activity
CTHE_RS02020	COG1063	alcohol dehydrogenase
CTHE_RS02025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CTHE_RS02030	COG1940	carbohydrate kinase activity
CTHE_RS02035	COG1129	ABC transporter
CTHE_RS02040	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTHE_RS02055	COG1869	D-ribose catabolic process
CTHE_RS02060	COG1132	(ABC) transporter
CTHE_RS02065	COG1132	(ABC) transporter
CTHE_RS02070	COG0393	Putative heavy-metal-binding
CTHE_RS02095	COG1191	sigma factor activity
CTHE_RS02100	COG4447	cellulose binding
CTHE_RS02125	COG3830	Belongs to the UPF0237 family
CTHE_RS02130	COG2848	UPF0210 protein
CTHE_RS02140	COG5297	Belongs to the glycosyl hydrolase family 6
CTHE_RS02140	COG2273	Hydrolase Family 16
CTHE_RS02150	COG3546	catalase activity
CTHE_RS02165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CTHE_RS02170	COG1185	polyribonucleotide nucleotidyltransferase activity
CTHE_RS02175	COG0612	Peptidase, M16
CTHE_RS02185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CTHE_RS02190	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CTHE_RS02195	COG1012	belongs to the aldehyde dehydrogenase family
CTHE_RS02195	COG1454	alcohol dehydrogenase
CTHE_RS02235	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CTHE_RS02270	COG4447	cellulose binding
CTHE_RS02280	COG3442	glutamine amidotransferase
CTHE_RS02285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CTHE_RS02290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CTHE_RS02295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CTHE_RS02300	COG3856	small basic protein
CTHE_RS02305	COG0849	cell division
CTHE_RS02310	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CTHE_RS02320	COG1191	sigma factor activity
CTHE_RS02325	COG1191	sigma factor activity
CTHE_RS02330	COG1873	PFAM PRC-barrel domain
CTHE_RS02335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CTHE_RS02360	COG0606	chelatase, subunit chli
CTHE_RS02365	COG0432	Pfam Uncharacterised protein family UPF0047
CTHE_RS02375	COG0708	Exodeoxyribonuclease III
CTHE_RS02380	COG0758	DNA mediated transformation
CTHE_RS02380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CTHE_RS02385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CTHE_RS02390	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CTHE_RS02400	COG1558	bacterial-type flagellum-dependent cell motility
CTHE_RS02405	COG1677	Flagellar hook-basal body complex protein FliE
CTHE_RS02415	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTHE_RS02420	COG1317	bacterial-type flagellum organization
CTHE_RS02425	COG1157	protein secretion by the type III secretion system
CTHE_RS02445	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CTHE_RS02460	COG1582	Flagellar protein (FlbD)
CTHE_RS02470	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTHE_RS02475	COG1776	CheC inhibitor of MCP methylation
CTHE_RS02475	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTHE_RS02480	COG2201	protein-glutamate methylesterase activity
CTHE_RS02490	COG1338	Plays a role in the flagellum-specific transport system
CTHE_RS02495	COG1987	bacterial-type flagellum assembly
CTHE_RS02500	COG1684	flagellar biosynthetic protein fliR
CTHE_RS02505	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CTHE_RS02510	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CTHE_RS02515	COG1419	protein localization to endoplasmic reticulum
CTHE_RS02530	COG2201	protein-glutamate methylesterase activity
CTHE_RS02535	COG0643	Histidine kinase
CTHE_RS02535	COG2198	Histidine kinase
CTHE_RS02540	COG0835	chemotaxis
CTHE_RS02545	COG1776	CheC inhibitor of MCP methylation
CTHE_RS02550	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CTHE_RS02560	COG1191	sigma factor activity
CTHE_RS02600	COG2843	Capsule synthesis protein
CTHE_RS02610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CTHE_RS02615	COG2176	DNA-directed DNA polymerase activity
CTHE_RS02630	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CTHE_RS02640	COG5002	protein histidine kinase activity
CTHE_RS02660	COG0582	viral genome integration into host DNA
CTHE_RS02680	COG4372	Transposase
CTHE_RS02710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CTHE_RS02770	COG2274	protein secretion by the type I secretion system
CTHE_RS02780	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CTHE_RS02780	COG4447	cellulose binding
CTHE_RS02785	COG0745	RESPONSE REGULATOR receiver
CTHE_RS02790	COG3850	Histidine kinase
CTHE_RS02790	COG5002	protein histidine kinase activity
CTHE_RS02795	COG1136	(ABC) transporter
CTHE_RS02800	COG0577	efflux transmembrane transporter activity
CTHE_RS02800	COG1136	(ABC) transporter
CTHE_RS02815	COG5297	Belongs to the glycosyl hydrolase family 6
CTHE_RS02820	COG0631	protein serine/threonine phosphatase activity
CTHE_RS02830	COG0735	belongs to the Fur family
CTHE_RS02835	COG0803	Belongs to the bacterial solute-binding protein 9 family
CTHE_RS02840	COG1121	(ABC) transporter
CTHE_RS02845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CTHE_RS02850	COG0326	Molecular chaperone. Has ATPase activity
CTHE_RS02860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CTHE_RS02870	COG0583	DNA-binding transcription factor activity
CTHE_RS02875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CTHE_RS02880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CTHE_RS02885	COG0367	asparagine synthase
CTHE_RS02890	COG0726	polysaccharide deacetylase
CTHE_RS02905	COG1252	NADH dehydrogenase
CTHE_RS02910	COG1477	protein flavinylation
CTHE_RS02935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CTHE_RS02940	COG0242	peptide deformylase activity
CTHE_RS02945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CTHE_RS02955	COG2738	Putative neutral zinc metallopeptidase
CTHE_RS02960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTHE_RS02960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CTHE_RS02965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CTHE_RS02970	COG0631	protein serine/threonine phosphatase activity
CTHE_RS02975	COG2815	serine threonine protein kinase
CTHE_RS02975	COG0515	serine threonine protein kinase
CTHE_RS02980	COG1162	GTPase activity
CTHE_RS02985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CTHE_RS03000	COG0778	Nitroreductase
CTHE_RS03005	COG0436	Aminotransferase
CTHE_RS03010	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CTHE_RS03020	COG2204	response regulator
CTHE_RS03045	COG3328	transposase activity
CTHE_RS03075	COG2226	methyltransferase
CTHE_RS03090	COG3328	transposase activity
CTHE_RS03100	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CTHE_RS03105	COG2022	thiamine diphosphate biosynthetic process
CTHE_RS03105	COG2104	thiamine diphosphate biosynthetic process
CTHE_RS03110	COG2022	thiamine diphosphate biosynthetic process
CTHE_RS03115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTHE_RS03125	COG0352	thiamine-phosphate diphosphorylase activity
CTHE_RS03130	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CTHE_RS03145	COG0791	NLP P60 protein
CTHE_RS03170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CTHE_RS03175	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CTHE_RS03205	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CTHE_RS03210	COG1918	ferrous iron import across plasma membrane
CTHE_RS03210	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CTHE_RS03220	COG1321	iron dependent repressor
CTHE_RS03225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CTHE_RS03230	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CTHE_RS03235	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CTHE_RS03245	COG5297	Belongs to the glycosyl hydrolase family 6
CTHE_RS03295	COG2815	serine threonine protein kinase
CTHE_RS03295	COG0515	serine threonine protein kinase
CTHE_RS03300	COG0631	protein serine/threonine phosphatase activity
CTHE_RS03320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CTHE_RS03325	COG2273	Hydrolase Family 16
CTHE_RS03345	COG3949	Membrane
CTHE_RS03370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTHE_RS03395	COG1942	4-Oxalocrotonate Tautomerase
CTHE_RS03410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CTHE_RS03435	COG4447	cellulose binding
CTHE_RS03440	COG2273	Hydrolase Family 16
CTHE_RS03460	COG3584	3D domain protein
CTHE_RS03460	COG3583	domain protein
CTHE_RS03470	COG0330	HflC and HflK could
CTHE_RS03475	COG0697	spore germination
CTHE_RS03505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CTHE_RS03510	COG0328	RNA-DNA hybrid ribonuclease activity
CTHE_RS03520	COG1300	Membrane
CTHE_RS03525	COG4974	Belongs to the 'phage' integrase family
CTHE_RS03530	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CTHE_RS03540	COG1686	Belongs to the peptidase S11 family
CTHE_RS03550	COG0516	GMP reductase activity
CTHE_RS03550	COG0517	IMP dehydrogenase activity
CTHE_RS03565	COG0617	tRNA 3'-terminal CCA addition
CTHE_RS03565	COG3620	sequence-specific DNA binding
CTHE_RS03565	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CTHE_RS03570	COG1994	Peptidase M50
CTHE_RS03575	COG0180	Tryptophanyl-tRNA synthetase
CTHE_RS03580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CTHE_RS03585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CTHE_RS03600	COG3874	Sporulation protein YtfJ
CTHE_RS03610	COG1187	pseudouridine synthase activity
CTHE_RS03615	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CTHE_RS03620	COG0010	Belongs to the arginase family
CTHE_RS03625	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CTHE_RS03640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CTHE_RS03650	COG0511	ligase activity, forming carbon-carbon bonds
CTHE_RS03675	COG1737	Transcriptional regulator
CTHE_RS03680	COG0406	alpha-ribazole phosphatase activity
CTHE_RS03685	COG2081	HI0933 family
CTHE_RS03710	COG0204	Acyl-transferase
CTHE_RS03720	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CTHE_RS03725	COG0105	UTP biosynthetic process
CTHE_RS03730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CTHE_RS03740	COG1959	2 iron, 2 sulfur cluster binding
CTHE_RS03750	COG0822	iron-sulfur transferase activity
CTHE_RS03755	COG0482	sulfurtransferase activity
CTHE_RS03760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CTHE_RS03765	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CTHE_RS03770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTHE_RS03770	COG2199	diguanylate cyclase activity
CTHE_RS03775	COG1362	aminopeptidase activity
CTHE_RS03785	COG4974	Belongs to the 'phage' integrase family
CTHE_RS03790	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CTHE_RS03805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CTHE_RS03820	COG2911	Protein conserved in bacteria
CTHE_RS03820	COG3266	domain, Protein
CTHE_RS03820	COG1361	Conserved repeat domain
CTHE_RS03825	COG1361	Conserved repeat domain
CTHE_RS03825	COG3266	domain, Protein
CTHE_RS03825	COG2911	Protein conserved in bacteria
CTHE_RS03845	COG2188	Transcriptional regulator
CTHE_RS03850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CTHE_RS03860	COG0534	Mate efflux family protein
CTHE_RS03865	COG3409	Peptidoglycan-binding domain 1 protein
CTHE_RS03865	COG0793	Belongs to the peptidase S41A family
CTHE_RS03870	COG4733	cellulase activity
CTHE_RS03890	COG1176	ABC-type spermidine putrescine transport system, permease component I
CTHE_RS03895	COG3842	ATPase activity
CTHE_RS03930	COG2003	Belongs to the UPF0758 family
CTHE_RS03935	COG0792	nuclease activity
CTHE_RS03950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CTHE_RS03970	COG0335	large ribosomal subunit rRNA binding
CTHE_RS03975	COG0336	Belongs to the RNA methyltransferase TrmD family
CTHE_RS03980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CTHE_RS03985	COG1837	Belongs to the UPF0109 family
CTHE_RS03990	COG0228	four-way junction DNA binding
CTHE_RS03995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CTHE_RS04000	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CTHE_RS04010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CTHE_RS04015	COG1923	regulation of RNA biosynthetic process
CTHE_RS04020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CTHE_RS04025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CTHE_RS04030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTHE_RS04040	COG2340	Cysteine-rich secretory protein family
CTHE_RS04045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CTHE_RS04060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTHE_RS04075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CTHE_RS04085	COG3599	regulation of cell shape
CTHE_RS04090	COG2302	S4 RNA-binding domain
CTHE_RS04100	COG1799	cell septum assembly
CTHE_RS04105	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CTHE_RS04115	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CTHE_RS04120	COG0366	Alpha amylase catalytic
CTHE_RS04130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CTHE_RS04130	COG2755	lipolytic protein G-D-S-L family
CTHE_RS04140	COG0745	RESPONSE REGULATOR receiver
CTHE_RS04145	COG5002	protein histidine kinase activity
CTHE_RS04150	COG3328	transposase activity
CTHE_RS04160	COG0564	pseudouridine synthase activity
CTHE_RS04170	COG0745	RESPONSE REGULATOR receiver
CTHE_RS04180	COG2201	protein-glutamate methylesterase activity
CTHE_RS04190	COG0835	chemotaxis
CTHE_RS04195	COG0643	Histidine kinase
CTHE_RS04195	COG2198	Histidine kinase
CTHE_RS04200	COG2201	protein-glutamate methylesterase activity
CTHE_RS04205	COG0745	RESPONSE REGULATOR receiver
CTHE_RS04210	COG0750	zinc metalloprotease
CTHE_RS04215	COG0497	DNA recombination
CTHE_RS04220	COG1438	arginine binding
CTHE_RS04225	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CTHE_RS04230	COG3706	GGDEF domain
CTHE_RS04240	COG1131	(ABC) transporter
CTHE_RS04275	COG3291	Pkd domain containing protein
CTHE_RS04285	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CTHE_RS04290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CTHE_RS04300	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CTHE_RS04310	COG1722	exodeoxyribonuclease VII activity
CTHE_RS04315	COG1570	exodeoxyribonuclease VII activity
CTHE_RS04320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTHE_RS04335	COG1302	Protein conserved in bacteria
CTHE_RS04375	COG3854	ATPases associated with a variety of cellular activities
CTHE_RS04385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CTHE_RS04390	COG0006	proline dipeptidase activity
CTHE_RS04395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CTHE_RS04410	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CTHE_RS04415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CTHE_RS04420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CTHE_RS04425	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CTHE_RS04430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTHE_RS04435	COG1030	water channel activity
CTHE_RS04440	COG4864	UPF0365 protein
CTHE_RS04450	COG1592	Rubrerythrin
CTHE_RS04455	COG1316	TRANSCRIPTIONal
CTHE_RS04505	COG0135	phosphoribosylanthranilate isomerase activity
CTHE_RS04510	COG0134	indole-3-glycerol-phosphate synthase activity
CTHE_RS04515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CTHE_RS04520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CTHE_RS04520	COG0512	Glutamine amidotransferase of anthranilate synthase
CTHE_RS04535	COG0012	GTP binding
CTHE_RS04540	COG0835	chemotaxis
CTHE_RS04550	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CTHE_RS04555	COG3706	GGDEF domain
CTHE_RS04560	COG0697	spore germination
CTHE_RS04575	COG0237	dephospho-CoA kinase activity
CTHE_RS04580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTHE_RS04580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTHE_RS04600	COG1595	DNA-templated transcription, initiation
CTHE_RS04605	COG3437	response regulator, receiver
CTHE_RS04610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CTHE_RS04615	COG2384	SAM-dependent methyltransferase
CTHE_RS04635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTHE_RS04640	COG0358	DNA primase activity
CTHE_RS04645	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CTHE_RS04660	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CTHE_RS04665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CTHE_RS04670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CTHE_RS04675	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTHE_RS04680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTHE_RS04685	COG1418	mRNA catabolic process
CTHE_RS04695	COG0564	pseudouridine synthase activity
CTHE_RS04700	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CTHE_RS04710	COG1496	oxidoreductase activity
CTHE_RS04720	COG3547	Transposase (IS116 IS110 IS902 family)
CTHE_RS04740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTHE_RS04770	COG1748	Saccharopine dehydrogenase
CTHE_RS04790	COG0552	protein localization to endoplasmic reticulum
CTHE_RS04805	COG2359	stage V sporulation protein S
CTHE_RS04815	COG0571	ribonuclease III activity
CTHE_RS04820	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CTHE_RS04825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTHE_RS04830	COG1028	Short-chain dehydrogenase reductase Sdr
CTHE_RS04835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CTHE_RS04840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CTHE_RS04845	COG0416	fatty acid biosynthetic process
CTHE_RS04850	COG2030	dehydratase
CTHE_RS04865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTHE_RS04870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTHE_RS04890	COG0588	phosphoglycerate mutase activity
CTHE_RS04895	COG0167	dihydroorotate dehydrogenase activity
CTHE_RS04900	COG0543	2 iron, 2 sulfur cluster binding
CTHE_RS04905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CTHE_RS04920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CTHE_RS04925	COG0540	Belongs to the ATCase OTCase family
CTHE_RS04935	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CTHE_RS04950	COG1862	Preprotein translocase
CTHE_RS04955	COG0343	queuine tRNA-ribosyltransferase activity
CTHE_RS04960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CTHE_RS04965	COG2385	sporulation resulting in formation of a cellular spore
CTHE_RS04965	COG2247	cell wall binding repeat
CTHE_RS04970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CTHE_RS04975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CTHE_RS04980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CTHE_RS04990	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CTHE_RS05025	COG3328	transposase activity
CTHE_RS05040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CTHE_RS05045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CTHE_RS05050	COG0772	Belongs to the SEDS family
CTHE_RS05055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTHE_RS05060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CTHE_RS05065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CTHE_RS05070	COG0768	penicillin binding
CTHE_RS05080	COG0275	rRNA processing
CTHE_RS05085	COG2001	Belongs to the MraZ family
CTHE_RS05090	COG0772	Belongs to the SEDS family
CTHE_RS05095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CTHE_RS05100	COG0612	Peptidase, M16
CTHE_RS05105	COG0612	Peptidase, M16
CTHE_RS05110	COG0196	riboflavin kinase activity
CTHE_RS05115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CTHE_RS05120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CTHE_RS05125	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CTHE_RS05130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CTHE_RS05140	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CTHE_RS05145	COG0195	Participates in both transcription termination and antitermination
CTHE_RS05150	COG0779	Required for maturation of 30S ribosomal subunits
CTHE_RS05160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CTHE_RS05170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CTHE_RS05175	COG0575	Belongs to the CDS family
CTHE_RS05180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CTHE_RS05190	COG0233	cytoplasmic translational termination
CTHE_RS05195	COG0528	UMP kinase activity
CTHE_RS05200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CTHE_RS05205	COG0052	Belongs to the universal ribosomal protein uS2 family
CTHE_RS05210	COG1217	gtp-binding protein TYPA
CTHE_RS05215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CTHE_RS05220	COG4122	O-methyltransferase activity
CTHE_RS05225	COG0826	peptidase U32
CTHE_RS05230	COG0768	penicillin binding
CTHE_RS05240	COG0628	permease
CTHE_RS05245	COG1193	negative regulation of DNA recombination
CTHE_RS05260	COG2247	cell wall binding repeat
CTHE_RS05260	COG0860	N-Acetylmuramoyl-L-alanine amidase
CTHE_RS05270	COG0395	ABC-type sugar transport system, permease component
CTHE_RS05275	COG1175	transmembrane transport
CTHE_RS05285	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CTHE_RS05290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CTHE_RS05300	COG1160	GTP binding
CTHE_RS05310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CTHE_RS05320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CTHE_RS05325	COG0280	phosphate acetyltransferase
CTHE_RS05335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTHE_RS05340	COG0154	amidase activity
CTHE_RS05345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTHE_RS05355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CTHE_RS05375	COG0268	Binds directly to 16S ribosomal RNA
CTHE_RS05380	COG1466	dna polymerase III delta subunit
CTHE_RS05400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CTHE_RS05440	COG0457	Tetratricopeptide repeat
CTHE_RS05440	COG0705	Rhomboid family
CTHE_RS05450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CTHE_RS05455	COG0728	peptidoglycan biosynthetic process
CTHE_RS05460	COG1058	Belongs to the CinA family
CTHE_RS05460	COG1546	Belongs to the CinA family
CTHE_RS05465	COG0039	L-malate dehydrogenase activity
CTHE_RS05470	COG0714	Associated with various cellular activities
CTHE_RS05480	COG1305	Transglutaminase-like
CTHE_RS05485	COG1983	PspC domain protein
CTHE_RS05490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CTHE_RS05510	COG2720	vancomycin resistance protein
CTHE_RS05515	COG0301	tRNA thio-modification
CTHE_RS05520	COG1104	cysteine desulfurase activity
CTHE_RS05535	COG1381	Involved in DNA repair and RecF pathway recombination
CTHE_RS05540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CTHE_RS05545	COG0295	cytidine deaminase activity
CTHE_RS05550	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CTHE_RS05555	COG1480	7TM receptor with intracellular HD hydrolase
CTHE_RS05560	COG1702	phosphate starvation-inducible protein PhoH
CTHE_RS05600	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CTHE_RS05620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CTHE_RS05630	COG0438	transferase activity, transferring glycosyl groups
CTHE_RS05650	COG2359	stage V sporulation protein S
CTHE_RS05655	COG1692	metallophosphoesterase
CTHE_RS05660	COG1418	mRNA catabolic process
CTHE_RS05670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CTHE_RS05680	COG1674	ftsk spoiiie
CTHE_RS05690	COG0740	serine-type endopeptidase activity
CTHE_RS05730	COG1459	type II secretion system
CTHE_RS05740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CTHE_RS05760	COG0798	PFAM Bile acid sodium symporter
CTHE_RS05765	COG0640	Transcriptional regulator
CTHE_RS05915	COG0515	serine threonine protein kinase
CTHE_RS05915	COG2815	serine threonine protein kinase
CTHE_RS06000	COG3706	GGDEF domain
CTHE_RS06055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CTHE_RS06060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTHE_RS06065	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CTHE_RS06075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CTHE_RS06085	COG3885	ferrous iron binding
CTHE_RS06085	COG2078	PFAM AMMECR1 domain protein
CTHE_RS06095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CTHE_RS06125	COG1406	Chemotaxis phosphatase CheX
CTHE_RS06130	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CTHE_RS06150	COG1305	Transglutaminase-like
CTHE_RS06160	COG0714	Associated with various cellular activities
CTHE_RS06175	COG0657	acetylesterase activity
CTHE_RS06190	COG4555	ABC transporter
CTHE_RS06200	COG0546	phosphoglycolate phosphatase activity
CTHE_RS06210	COG3328	transposase activity
CTHE_RS06240	COG0402	S-adenosylhomocysteine deaminase activity
CTHE_RS06245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CTHE_RS06260	COG2719	SpoVR family
CTHE_RS06265	COG2718	Belongs to the UPF0229 family
CTHE_RS06270	COG2766	serine protein kinase
CTHE_RS06300	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CTHE_RS06320	COG0730	response to heat
CTHE_RS06325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CTHE_RS06330	COG0542	response to heat
CTHE_RS06335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CTHE_RS06350	COG3459	Glycosyltransferase 36 associated
CTHE_RS06355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTHE_RS06360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CTHE_RS06365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CTHE_RS06370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CTHE_RS06375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CTHE_RS06390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CTHE_RS06400	COG1555	photosystem II stabilization
CTHE_RS06400	COG1596	polysaccharide export
CTHE_RS06405	COG1686	Belongs to the peptidase S11 family
CTHE_RS06410	COG1022	Amp-dependent synthetase and ligase
CTHE_RS06420	COG0840	transmembrane signaling receptor activity
CTHE_RS06435	COG0495	leucyl-tRNA aminoacylation
CTHE_RS06440	COG0799	negative regulation of ribosome biogenesis
CTHE_RS06450	COG1713	HD superfamily hydrolase involved in NAD metabolism
CTHE_RS06455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CTHE_RS06470	COG1216	Glycosyl transferase, family 2
CTHE_RS06475	COG0151	Belongs to the GarS family
CTHE_RS06480	COG0138	bifunctional purine biosynthesis protein purh
CTHE_RS06485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CTHE_RS06490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CTHE_RS06495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CTHE_RS06500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CTHE_RS06505	COG2252	PERMEase
CTHE_RS06525	COG1472	Belongs to the glycosyl hydrolase 3 family
CTHE_RS06550	COG0205	6-phosphofructokinase activity
CTHE_RS06570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTHE_RS06575	COG0840	transmembrane signaling receptor activity
CTHE_RS06580	COG2197	response regulator
CTHE_RS06600	COG3507	Belongs to the glycosyl hydrolase 43 family
CTHE_RS06605	COG1191	sigma factor activity
CTHE_RS06610	COG2755	lipolytic protein G-D-S-L family
CTHE_RS06615	COG3314	Sporulation integral membrane protein YlbJ
CTHE_RS06625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CTHE_RS06630	COG0742	ribosomal rna small subunit methyltransferase
CTHE_RS06635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CTHE_RS06640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CTHE_RS06660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CTHE_RS06665	COG0297	glycogen (starch) synthase activity
CTHE_RS06670	COG2199	diguanylate cyclase activity
CTHE_RS06670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTHE_RS06675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTHE_RS06680	COG3850	Histidine kinase
CTHE_RS06680	COG5002	protein histidine kinase activity
CTHE_RS06685	COG0745	RESPONSE REGULATOR receiver
CTHE_RS06705	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
CTHE_RS06720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CTHE_RS06730	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CTHE_RS06750	COG1323	Belongs to the UPF0348 family
CTHE_RS06755	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CTHE_RS06765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CTHE_RS06770	COG0662	Cupin 2, conserved barrel domain protein
CTHE_RS06785	COG3693	PFAM glycoside hydrolase, family 10
CTHE_RS06790	COG0574	Belongs to the PEP-utilizing enzyme family
CTHE_RS06790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTHE_RS06795	COG0535	radical SAM domain protein
CTHE_RS06805	COG3290	protein histidine kinase activity
CTHE_RS06810	COG0423	glycine-tRNA ligase activity
CTHE_RS06815	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CTHE_RS06820	COG1758	RNA polymerase activity
CTHE_RS06825	COG0194	GDP metabolic process
CTHE_RS06830	COG2052	Domain of unknown function (DUF370)
CTHE_RS06835	COG1561	YicC-like family, N-terminal region
CTHE_RS06845	COG2201	protein-glutamate methylesterase activity
CTHE_RS06850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CTHE_RS06855	COG2264	protein methyltransferase activity
CTHE_RS06860	COG0484	heat shock protein binding
CTHE_RS06865	COG0443	Heat shock 70 kDa protein
CTHE_RS06870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CTHE_RS06875	COG1420	regulation of RNA biosynthetic process
CTHE_RS06880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTHE_RS06885	COG0481	GTPase activity
CTHE_RS06915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CTHE_RS06920	COG0124	histidyl-tRNA synthetase
CTHE_RS06970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTHE_RS06975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTHE_RS06980	COG1490	D-aminoacyl-tRNA deacylase activity
CTHE_RS06985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CTHE_RS06990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTHE_RS06995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTHE_RS06995	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CTHE_RS07005	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CTHE_RS07010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTHE_RS07015	COG0629	single-stranded DNA binding
CTHE_RS07025	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CTHE_RS07040	COG1216	Glycosyl transferase, family 2
CTHE_RS07080	COG0489	protein tyrosine kinase activity
CTHE_RS07100	COG4464	protein tyrosine phosphatase activity
CTHE_RS07105	COG1361	Conserved repeat domain
CTHE_RS07110	COG0537	adenosine 5'-monophosphoramidase activity
CTHE_RS07145	COG0527	aspartate kinase activity
CTHE_RS07150	COG0460	homoserine dehydrogenase
CTHE_RS07155	COG4492	Belongs to the UPF0735 family
CTHE_RS07160	COG2199	diguanylate cyclase activity
CTHE_RS07160	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTHE_RS07165	COG0673	inositol 2-dehydrogenase activity
CTHE_RS07170	COG2201	protein-glutamate methylesterase activity
CTHE_RS07180	COG1752	Esterase of the alpha-beta hydrolase superfamily
CTHE_RS07190	COG0285	dihydrofolate synthase activity
CTHE_RS07195	COG0653	protein targeting
CTHE_RS07210	COG4496	protein, YerC YecD
CTHE_RS07220	COG0617	tRNA 3'-terminal CCA addition
CTHE_RS07225	COG2267	carboxylic ester hydrolase activity
CTHE_RS07230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTHE_RS07240	COG5002	protein histidine kinase activity
CTHE_RS07245	COG0745	RESPONSE REGULATOR receiver
CTHE_RS07255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CTHE_RS07260	COG1442	glycosyl transferase family 8
CTHE_RS07265	COG4447	cellulose binding
CTHE_RS07285	COG1321	iron dependent repressor
CTHE_RS07295	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CTHE_RS07300	COG5337	Spore coat protein CotH
CTHE_RS07315	COG0745	RESPONSE REGULATOR receiver
CTHE_RS07320	COG5002	protein histidine kinase activity
CTHE_RS07325	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CTHE_RS07330	COG0159	tryptophan synthase activity
CTHE_RS07335	COG0133	tryptophan synthase activity
CTHE_RS07350	COG1131	(ABC) transporter
CTHE_RS07365	COG1971	Probably functions as a manganese efflux pump
CTHE_RS07370	COG0616	signal peptide processing
CTHE_RS07375	COG1714	RDD family
CTHE_RS07380	COG0628	permease
CTHE_RS07390	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CTHE_RS07395	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CTHE_RS07430	COG1028	Short-chain dehydrogenase reductase Sdr
CTHE_RS07455	COG1595	DNA-templated transcription, initiation
CTHE_RS07495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTHE_RS07545	COG1126	abc transporter atp-binding protein
CTHE_RS07565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CTHE_RS07565	COG0723	plastoquinol--plastocyanin reductase activity
CTHE_RS07585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CTHE_RS07610	COG1595	DNA-templated transcription, initiation
CTHE_RS07620	COG4124	Belongs to the glycosyl hydrolase 26 family
CTHE_RS07620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CTHE_RS07640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CTHE_RS07650	COG0717	Belongs to the dCTP deaminase family
CTHE_RS07665	COG2409	Drug exporters of the RND superfamily
CTHE_RS07675	COG0561	phosphatase activity
CTHE_RS07690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CTHE_RS07690	COG0426	domain, Protein
CTHE_RS07695	COG0494	nUDIX hydrolase
CTHE_RS07705	COG0840	transmembrane signaling receptor activity
CTHE_RS07730	COG1695	Transcriptional regulator
CTHE_RS07755	COG0840	transmembrane signaling receptor activity
CTHE_RS07760	COG0004	ammonium transporteR
CTHE_RS07765	COG1132	(ABC) transporter
CTHE_RS07770	COG1132	(ABC) transporter
CTHE_RS07790	COG1361	Conserved repeat domain
CTHE_RS07805	COG1393	Belongs to the ArsC family
CTHE_RS07895	COG0577	efflux transmembrane transporter activity
CTHE_RS07900	COG1136	(ABC) transporter
CTHE_RS07905	COG2205	protein histidine kinase activity
CTHE_RS07910	COG0745	RESPONSE REGULATOR receiver
CTHE_RS07935	COG3328	transposase activity
CTHE_RS07950	COG1131	(ABC) transporter
CTHE_RS07960	COG3620	sequence-specific DNA binding
CTHE_RS07970	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTHE_RS07975	COG0154	amidase activity
CTHE_RS07985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CTHE_RS08010	COG1024	Enoyl-CoA hydratase
CTHE_RS08015	COG4106	trans-aconitate 2-methyltransferase activity
CTHE_RS08020	COG3547	Transposase (IS116 IS110 IS902 family)
CTHE_RS08050	COG1464	Belongs to the NlpA lipoprotein family
CTHE_RS08055	COG2011	ABC-type metal ion transport system permease component
CTHE_RS08060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CTHE_RS08070	COG0626	cystathionine gamma-synthase activity
CTHE_RS08075	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CTHE_RS08115	COG0535	radical SAM domain protein
CTHE_RS08120	COG2873	o-acetylhomoserine
CTHE_RS08125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTHE_RS08130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTHE_RS08140	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CTHE_RS08150	COG0813	purine-nucleoside phosphorylase activity
CTHE_RS08155	COG1744	ABC transporter substrate-binding protein PnrA-like
CTHE_RS08160	COG1328	CTP reductase activity
CTHE_RS08165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CTHE_RS08170	COG3845	ABC transporter
CTHE_RS08175	COG4603	Belongs to the binding-protein-dependent transport system permease family
CTHE_RS08180	COG1079	Belongs to the binding-protein-dependent transport system permease family
CTHE_RS08185	COG0295	cytidine deaminase activity
CTHE_RS08195	COG2207	Transcriptional regulator
CTHE_RS08195	COG4753	response regulator
CTHE_RS08210	COG3842	ATPase activity
CTHE_RS08240	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CTHE_RS08275	COG5002	protein histidine kinase activity
CTHE_RS08280	COG0745	RESPONSE REGULATOR receiver
CTHE_RS08285	COG0704	Plays a role in the regulation of phosphate uptake
CTHE_RS08290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CTHE_RS08295	COG0581	inorganic phosphate transmembrane transporter activity
CTHE_RS08300	COG0573	inorganic phosphate transmembrane transporter activity
CTHE_RS08420	COG0740	serine-type endopeptidase activity
CTHE_RS08425	COG4695	Portal protein
CTHE_RS08525	COG3617	BRO family, N-terminal domain
CTHE_RS08530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTHE_RS08530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTHE_RS08570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CTHE_RS08575	COG0569	domain protein
CTHE_RS08610	COG0789	Transcriptional regulator
CTHE_RS08615	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CTHE_RS08630	COG1131	(ABC) transporter
CTHE_RS08690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CTHE_RS08715	COG1132	(ABC) transporter
CTHE_RS08740	COG0535	radical SAM domain protein
CTHE_RS08770	COG0535	radical SAM domain protein
CTHE_RS08800	COG0860	N-Acetylmuramoyl-L-alanine amidase
CTHE_RS08890	COG0740	serine-type endopeptidase activity
CTHE_RS08940	COG0270	DNA (cytosine-5-)-methyltransferase activity
CTHE_RS09005	COG3617	BRO family, N-terminal domain
CTHE_RS09075	COG1120	ATPase activity
CTHE_RS09080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTHE_RS09085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CTHE_RS09095	COG0739	heme binding
CTHE_RS09115	COG0577	efflux transmembrane transporter activity
CTHE_RS09125	COG1136	(ABC) transporter
CTHE_RS09165	COG1592	Rubrerythrin
CTHE_RS09175	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CTHE_RS09180	COG1067	ATP-dependent peptidase activity
CTHE_RS09185	COG0456	acetyltransferase
CTHE_RS09190	COG1214	PFAM Peptidase M22, glycoprotease
CTHE_RS09195	COG0802	atpase or kinase
CTHE_RS09200	COG1228	amidohydrolase
CTHE_RS09230	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CTHE_RS09235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CTHE_RS09245	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CTHE_RS09250	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CTHE_RS09260	COG1215	transferase activity, transferring glycosyl groups
CTHE_RS09265	COG0542	response to heat
CTHE_RS09270	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CTHE_RS09275	COG3880	PFAM UvrB UvrC protein
CTHE_RS09295	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CTHE_RS09300	COG0287	Prephenate dehydrogenase
CTHE_RS09305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CTHE_RS09310	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CTHE_RS09315	COG0488	(ABC) transporter
CTHE_RS09325	COG1122	ATPase activity
CTHE_RS09335	COG0310	cobalt ion transport
CTHE_RS09340	COG0860	N-Acetylmuramoyl-L-alanine amidase
CTHE_RS09345	COG0745	RESPONSE REGULATOR receiver
CTHE_RS09370	COG3547	Transposase (IS116 IS110 IS902 family)
CTHE_RS09375	COG1595	DNA-templated transcription, initiation
CTHE_RS09390	COG0829	nickel cation binding
CTHE_RS09395	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CTHE_RS09405	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CTHE_RS09410	COG0804	urea catabolic process
CTHE_RS09450	COG2207	Transcriptional regulator
CTHE_RS09450	COG4753	response regulator
CTHE_RS09460	COG4251	negative regulation of phosphorylation
CTHE_RS09520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTHE_RS09530	COG1606	tRNA processing
CTHE_RS09540	COG1959	2 iron, 2 sulfur cluster binding
CTHE_RS09545	COG1959	2 iron, 2 sulfur cluster binding
CTHE_RS09550	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CTHE_RS09555	COG5002	protein histidine kinase activity
CTHE_RS09560	COG0745	RESPONSE REGULATOR receiver
CTHE_RS09565	COG2217	Heavy metal translocating P-type atpase
CTHE_RS09610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CTHE_RS09615	COG1278	Cold shock
CTHE_RS09620	COG3695	enzyme binding
CTHE_RS09635	COG3409	Peptidoglycan-binding domain 1 protein
CTHE_RS09635	COG0793	Belongs to the peptidase S41A family
CTHE_RS09645	COG2177	Part of the ABC transporter FtsEX involved in
CTHE_RS09650	COG2884	Cell division ATP-binding protein ftsE
CTHE_RS09655	COG3835	regulator
CTHE_RS09660	COG3842	ATPase activity
CTHE_RS09665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CTHE_RS09670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CTHE_RS09680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CTHE_RS09685	COG0505	Belongs to the CarA family
CTHE_RS09690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CTHE_RS09695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CTHE_RS09725	COG3328	transposase activity
CTHE_RS09785	COG3547	Transposase (IS116 IS110 IS902 family)
CTHE_RS09790	COG4974	Belongs to the 'phage' integrase family
CTHE_RS09815	COG3328	transposase activity
CTHE_RS09820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CTHE_RS09840	COG1695	Transcriptional regulator
CTHE_RS09845	COG1408	metallophosphoesterase
CTHE_RS09860	COG1876	peptidase activity
CTHE_RS09870	COG3328	transposase activity
CTHE_RS09880	COG0726	polysaccharide deacetylase
CTHE_RS09900	COG1028	Short-chain dehydrogenase reductase Sdr
CTHE_RS09900	COG0318	PFAM AMP-dependent synthetase and ligase
CTHE_RS09900	COG0300	oxidoreductase activity
CTHE_RS09900	COG3321	synthase
CTHE_RS09900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CTHE_RS09940	COG5002	protein histidine kinase activity
CTHE_RS09945	COG0745	RESPONSE REGULATOR receiver
CTHE_RS09950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CTHE_RS09955	COG1982	Orn Lys Arg decarboxylase major
CTHE_RS09960	COG1285	pathogenesis
CTHE_RS09970	COG1695	Transcriptional regulator
CTHE_RS09980	COG0504	CTP synthase activity
CTHE_RS10020	COG3409	Peptidoglycan-binding domain 1 protein
CTHE_RS10020	COG0793	Belongs to the peptidase S41A family
CTHE_RS10035	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CTHE_RS10045	COG0018	arginyl-trna synthetase
CTHE_RS10055	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CTHE_RS10060	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTHE_RS10065	COG2239	Acts as a magnesium transporter
CTHE_RS10085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CTHE_RS10090	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CTHE_RS10095	COG0492	ferredoxin-NADP+ reductase activity
CTHE_RS10105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CTHE_RS10110	COG0785	Cytochrome C biogenesis protein
CTHE_RS10140	COG2183	response to ionizing radiation
CTHE_RS10165	COG2226	methyltransferase
CTHE_RS10175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CTHE_RS10185	COG3693	PFAM glycoside hydrolase, family 10
CTHE_RS10185	COG2382	esterase
CTHE_RS10185	COG3507	Belongs to the glycosyl hydrolase 43 family
CTHE_RS10190	COG3634	alkyl hydroperoxide reductase activity
CTHE_RS10195	COG0450	alkyl hydroperoxide reductase
CTHE_RS10205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CTHE_RS10405	COG4584	PFAM Integrase catalytic
CTHE_RS10405	COG2390	Transcriptional regulator
CTHE_RS10465	COG3328	transposase activity
CTHE_RS10545	COG0457	Tetratricopeptide repeat
CTHE_RS10545	COG0515	serine threonine protein kinase
CTHE_RS10550	COG2226	methyltransferase
CTHE_RS10555	COG2226	methyltransferase
CTHE_RS10580	COG1074	ATP-dependent DNA helicase activity
CTHE_RS10585	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CTHE_RS10675	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CTHE_RS10700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTHE_RS10710	COG0697	spore germination
CTHE_RS10725	COG0215	cysteine-tRNA ligase activity
CTHE_RS10730	COG1045	serine acetyltransferase
CTHE_RS10765	COG1473	amidohydrolase
CTHE_RS10770	COG2155	Conserved Protein
CTHE_RS10775	COG0217	transcriptional regulatory protein
CTHE_RS10780	COG5002	protein histidine kinase activity
CTHE_RS10790	COG1739	Uncharacterized protein family UPF0029
CTHE_RS10795	COG0681	Belongs to the peptidase S26 family
CTHE_RS10800	COG0494	nUDIX hydrolase
CTHE_RS10805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CTHE_RS10815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CTHE_RS10825	COG0756	dUTP diphosphatase activity
CTHE_RS10830	COG0826	peptidase U32
CTHE_RS10835	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CTHE_RS10845	COG5297	Belongs to the glycosyl hydrolase family 6
CTHE_RS10865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CTHE_RS10870	COG3584	3D domain protein
CTHE_RS10870	COG3583	domain protein
CTHE_RS10880	COG0084	hydrolase, TatD family'
CTHE_RS10885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTHE_RS10885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTHE_RS10895	COG0700	Nucleoside recognition
CTHE_RS10900	COG2715	membrane protein required for spore maturation
CTHE_RS10905	COG2002	toxin-antitoxin pair type II binding
CTHE_RS10910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CTHE_RS10915	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CTHE_RS10925	COG1774	PSP1 C-terminal conserved region
CTHE_RS10930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CTHE_RS10935	COG1728	Protein conserved in bacteria
CTHE_RS10945	COG1982	Orn Lys Arg decarboxylase major
CTHE_RS10960	COG1136	(ABC) transporter
CTHE_RS10975	COG5002	protein histidine kinase activity
CTHE_RS10990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTHE_RS10995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTHE_RS11005	COG3693	PFAM glycoside hydrolase, family 10
CTHE_RS11010	COG1191	sigma factor activity
CTHE_RS11035	COG0395	ABC-type sugar transport system, permease component
CTHE_RS11040	COG1175	transmembrane transport
CTHE_RS11045	COG0714	Associated with various cellular activities
CTHE_RS11100	COG3940	Belongs to the glycosyl hydrolase 43 family
CTHE_RS11105	COG3940	Belongs to the glycosyl hydrolase 43 family
CTHE_RS11120	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CTHE_RS11125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CTHE_RS11130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CTHE_RS11135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CTHE_RS11195	COG1361	Conserved repeat domain
CTHE_RS11235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CTHE_RS11245	COG1773	rubredoxin
CTHE_RS11270	COG1408	metallophosphoesterase
CTHE_RS11285	COG0254	rRNA binding
CTHE_RS11295	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CTHE_RS11335	COG0038	chloride channel
CTHE_RS11345	COG0037	tRNA processing
CTHE_RS11355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CTHE_RS11360	COG1295	ribonuclease BN
CTHE_RS11365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CTHE_RS11370	COG0629	single-stranded DNA binding
CTHE_RS11375	COG0360	Binds together with S18 to 16S ribosomal RNA
CTHE_RS11390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CTHE_RS11395	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CTHE_RS11410	COG2382	esterase
CTHE_RS11410	COG3693	PFAM glycoside hydrolase, family 10
CTHE_RS11410	COG3507	Belongs to the glycosyl hydrolase 43 family
CTHE_RS11415	COG2382	esterase
CTHE_RS11415	COG3693	PFAM glycoside hydrolase, family 10
CTHE_RS11415	COG3507	Belongs to the glycosyl hydrolase 43 family
CTHE_RS11420	COG3693	PFAM glycoside hydrolase, family 10
CTHE_RS11420	COG3507	Belongs to the glycosyl hydrolase 43 family
CTHE_RS11420	COG2382	esterase
CTHE_RS11425	COG3507	Belongs to the glycosyl hydrolase 43 family
CTHE_RS11430	COG3250	beta-galactosidase activity
CTHE_RS11435	COG4584	PFAM Integrase catalytic
CTHE_RS11435	COG2390	Transcriptional regulator
CTHE_RS11445	COG3250	beta-galactosidase activity
CTHE_RS11450	COG3328	transposase activity
CTHE_RS11460	COG0302	gtp cyclohydrolase
CTHE_RS11465	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTHE_RS11465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CTHE_RS11470	COG4242	Belongs to the peptidase S51 family
CTHE_RS11480	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CTHE_RS11485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CTHE_RS11490	COG0473	3-isopropylmalate dehydrogenase activity
CTHE_RS11495	COG0066	3-isopropylmalate dehydratase activity
CTHE_RS11500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CTHE_RS11505	COG2207	Transcriptional regulator
CTHE_RS11510	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CTHE_RS11535	COG1516	flagellar protein fliS
CTHE_RS11540	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CTHE_RS11550	COG1088	dTDP-glucose 4,6-dehydratase activity
CTHE_RS11555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CTHE_RS11570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CTHE_RS11585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTHE_RS11595	COG2089	acid synthase
CTHE_RS11600	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CTHE_RS11605	COG2226	methyltransferase
CTHE_RS11610	COG1086	Polysaccharide biosynthesis protein
CTHE_RS11630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CTHE_RS11635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CTHE_RS11645	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CTHE_RS11650	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CTHE_RS11660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CTHE_RS11665	COG1256	bacterial-type flagellum assembly
CTHE_RS11665	COG4786	Flagellar basal body rod
CTHE_RS11690	COG1040	competence protein
CTHE_RS11695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CTHE_RS11705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CTHE_RS11715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTHE_RS11720	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CTHE_RS11725	COG0037	tRNA processing
CTHE_RS11730	COG0305	Participates in initiation and elongation during chromosome replication
CTHE_RS11735	COG0359	binds to the 23S rRNA
CTHE_RS11740	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CTHE_RS11750	COG0077	Prephenate dehydratase
CTHE_RS11750	COG1605	Chorismate mutase
CTHE_RS11760	COG1269	ATP hydrolysis coupled proton transport
CTHE_RS11765	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTHE_RS11770	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CTHE_RS11785	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CTHE_RS11790	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CTHE_RS11795	COG1394	ATPase activity, coupled to movement of substances
CTHE_RS11800	COG0488	(ABC) transporter
CTHE_RS11835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTHE_RS11850	COG0765	amino acid transport
CTHE_RS11860	COG2201	protein-glutamate methylesterase activity
CTHE_RS11865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CTHE_RS11875	COG0643	Histidine kinase
CTHE_RS11875	COG2198	Histidine kinase
CTHE_RS11880	COG0835	chemotaxis
CTHE_RS11885	COG0582	viral genome integration into host DNA
CTHE_RS11890	COG3708	Transcriptional regulator
CTHE_RS11890	COG2207	Transcriptional regulator
CTHE_RS11905	COG1131	(ABC) transporter
CTHE_RS11925	COG2390	Transcriptional regulator
CTHE_RS11925	COG4584	PFAM Integrase catalytic
CTHE_RS11940	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CTHE_RS11945	COG1518	maintenance of DNA repeat elements
CTHE_RS11985	COG1968	undecaprenyl-diphosphatase activity
CTHE_RS11990	COG0534	Mate efflux family protein
CTHE_RS12105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CTHE_RS12110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CTHE_RS12115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CTHE_RS12135	COG5002	protein histidine kinase activity
CTHE_RS12140	COG0745	RESPONSE REGULATOR receiver
CTHE_RS12160	COG0438	transferase activity, transferring glycosyl groups
CTHE_RS12170	COG0438	transferase activity, transferring glycosyl groups
CTHE_RS12200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTHE_RS12205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CTHE_RS12220	COG1361	Conserved repeat domain
CTHE_RS12230	COG3773	Cell wall hydrolase
CTHE_RS12240	COG0517	IMP dehydrogenase activity
CTHE_RS12255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CTHE_RS12260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CTHE_RS12295	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CTHE_RS12300	COG4733	cellulase activity
CTHE_RS12300	COG4447	cellulose binding
CTHE_RS12305	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CTHE_RS12310	COG1475	DNA binding
CTHE_RS12315	COG0357	Ribosomal RNA small subunit methyltransferase G
CTHE_RS12325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CTHE_RS12330	COG1847	R3H domain protein
CTHE_RS12335	COG0706	membrane insertase activity
CTHE_RS12340	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CTHE_RS12350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CTHE_RS12355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CTHE_RS12360	COG0592	DNA-directed DNA polymerase activity
CTHE_RS12370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTHE_RS12380	COG0187	DNA topoisomerase II activity
CTHE_RS12385	COG1192	Involved in chromosome partitioning
CTHE_RS12390	COG1475	DNA binding
CTHE_RS12405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CTHE_RS12420	COG2814	Major facilitator Superfamily
CTHE_RS12430	COG2373	Large extracellular alpha-helical protein
CTHE_RS12440	COG2720	vancomycin resistance protein
CTHE_RS12460	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CTHE_RS12470	COG0674	pyruvate-flavodoxin oxidoreductase activity
CTHE_RS12475	COG1013	pyruvate-flavodoxin oxidoreductase activity
CTHE_RS12505	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CTHE_RS12525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CTHE_RS12530	COG1802	Transcriptional regulator
CTHE_RS12535	COG2608	mercury ion transmembrane transporter activity
CTHE_RS12545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTHE_RS12570	COG4717	serine-type aminopeptidase activity
CTHE_RS12575	COG0791	NLP P60 protein
CTHE_RS12580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CTHE_RS12590	COG2959	enzyme of heme biosynthesis
CTHE_RS12615	COG1078	dGTPase activity
CTHE_RS12650	COG3872	metal-dependent enzyme
CTHE_RS12655	COG2890	protein-(glutamine-N5) methyltransferase activity
CTHE_RS12665	COG4656	Part of a membrane complex involved in electron transport
CTHE_RS12670	COG4658	electron transport chain
CTHE_RS12675	COG4659	FMN binding
CTHE_RS12680	COG4660	Part of a membrane complex involved in electron transport
CTHE_RS12685	COG4657	Part of a membrane complex involved in electron transport
CTHE_RS12690	COG2878	Part of a membrane complex involved in electron transport
CTHE_RS12715	COG1349	DNA-binding transcription factor activity
CTHE_RS12720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CTHE_RS12725	COG3959	Transketolase, thiamine diphosphate binding domain
CTHE_RS12730	COG3958	Transketolase
CTHE_RS12735	COG1063	alcohol dehydrogenase
CTHE_RS12740	COG1879	ABC-type sugar transport system periplasmic component
CTHE_RS12745	COG1129	ABC transporter
CTHE_RS12755	COG0406	alpha-ribazole phosphatase activity
CTHE_RS12765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CTHE_RS12770	COG1164	Oligoendopeptidase f
CTHE_RS12780	COG3693	PFAM glycoside hydrolase, family 10
CTHE_RS12790	COG0582	viral genome integration into host DNA
CTHE_RS12815	COG1396	sequence-specific DNA binding
CTHE_RS12825	COG3617	BRO family, N-terminal domain
CTHE_RS12875	COG1484	DNA-dependent DNA replication
CTHE_RS12915	COG1783	phage Terminase large subunit
CTHE_RS12965	COG3547	Transposase (IS116 IS110 IS902 family)
CTHE_RS12995	COG2823	Periplasmic or secreted lipoprotein
CTHE_RS12995	COG1652	LysM domain
CTHE_RS13000	COG4193	domain, Protein
CTHE_RS13015	COG3299	homolog of phage Mu protein gp47
CTHE_RS13045	COG3409	Peptidoglycan-binding domain 1 protein
CTHE_RS13045	COG5632	N-Acetylmuramoyl-L-alanine amidase
CTHE_RS13065	COG0590	tRNA wobble adenosine to inosine editing
CTHE_RS13080	COG0662	Cupin 2, conserved barrel domain protein
CTHE_RS13090	COG1609	Transcriptional regulator
CTHE_RS13115	COG0668	transmembrane transport
CTHE_RS13125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTHE_RS13135	COG0590	tRNA wobble adenosine to inosine editing
CTHE_RS13140	COG0028	Belongs to the TPP enzyme family
CTHE_RS13145	COG0440	acetolactate synthase activity
CTHE_RS13150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CTHE_RS13155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTHE_RS13165	COG1191	sigma factor activity
CTHE_RS13180	COG1959	2 iron, 2 sulfur cluster binding
CTHE_RS13185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CTHE_RS13195	COG0181	hydroxymethylbilane synthase activity
CTHE_RS13205	COG0113	porphobilinogen synthase activity
CTHE_RS13210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CTHE_RS13215	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CTHE_RS13220	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CTHE_RS13225	COG4208	sulfate ABC transporter
CTHE_RS13235	COG0175	sulfate reduction
CTHE_RS13240	COG0175	sulfate reduction
CTHE_RS13255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CTHE_RS13280	COG1595	DNA-templated transcription, initiation
CTHE_RS13305	COG3534	alpha-L-arabinofuranosidase
CTHE_RS13310	COG5297	Belongs to the glycosyl hydrolase family 6
CTHE_RS13320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CTHE_RS13330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CTHE_RS13345	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CTHE_RS13350	COG1216	Glycosyl transferase, family 2
CTHE_RS13355	COG1088	dTDP-glucose 4,6-dehydratase activity
CTHE_RS13365	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CTHE_RS13395	COG1032	radical SAM domain protein
CTHE_RS13435	COG1116	anion transmembrane transporter activity
CTHE_RS13440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTHE_RS13445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTHE_RS13455	COG2954	triphosphatase activity
CTHE_RS13475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CTHE_RS13480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CTHE_RS13485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CTHE_RS13495	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CTHE_RS13495	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CTHE_RS13510	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CTHE_RS13520	COG3693	PFAM glycoside hydrolase, family 10
CTHE_RS13535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CTHE_RS13540	COG0428	transporter
CTHE_RS13545	COG0009	L-threonylcarbamoyladenylate synthase
CTHE_RS13555	COG0698	ribose 5-phosphate isomerase
CTHE_RS13560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CTHE_RS13565	COG2131	deaminase
CTHE_RS13570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTHE_RS13575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CTHE_RS13580	COG0356	it plays a direct role in the translocation of protons across the membrane
CTHE_RS13585	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTHE_RS13590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CTHE_RS13595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTHE_RS13600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CTHE_RS13605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CTHE_RS13610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CTHE_RS13615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CTHE_RS13635	COG3266	domain, Protein
CTHE_RS13635	COG1361	Conserved repeat domain
CTHE_RS13635	COG2911	Protein conserved in bacteria
CTHE_RS13645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CTHE_RS13650	COG2385	sporulation resulting in formation of a cellular spore
CTHE_RS13660	COG1609	Transcriptional regulator
CTHE_RS13670	COG4786	Flagellar basal body rod
CTHE_RS13695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CTHE_RS13700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CTHE_RS13705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTHE_RS13710	COG2088	sporulation resulting in formation of a cellular spore
CTHE_RS13715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CTHE_RS13725	COG0193	aminoacyl-tRNA hydrolase activity
CTHE_RS13730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CTHE_RS13735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CTHE_RS13740	COG2207	Transcriptional regulator
CTHE_RS13740	COG1917	Cupin 2, conserved barrel domain protein
CTHE_RS13745	COG0259	pyridoxamine-phosphate oxidase activity
CTHE_RS13750	COG0728	peptidoglycan biosynthetic process
CTHE_RS13770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CTHE_RS13775	COG2089	acid synthase
CTHE_RS13785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTHE_RS13790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CTHE_RS13795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CTHE_RS13805	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTHE_RS13810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTHE_RS13840	COG4464	protein tyrosine phosphatase activity
CTHE_RS13845	COG2002	toxin-antitoxin pair type II binding
CTHE_RS13850	COG3956	TIGRFAM MazG family protein
CTHE_RS13860	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CTHE_RS13880	COG1098	S1 RNA binding domain
CTHE_RS13895	COG0840	transmembrane signaling receptor activity
CTHE_RS13900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CTHE_RS13935	COG3328	transposase activity
CTHE_RS13940	COG3328	transposase activity
CTHE_RS13970	COG4191	Histidine kinase
CTHE_RS13985	COG0793	Belongs to the peptidase S41A family
CTHE_RS14030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CTHE_RS14035	COG0849	cell division
CTHE_RS14040	COG1607	acyl-coa hydrolase
CTHE_RS14045	COG2244	polysaccharide biosynthetic process
CTHE_RS14050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTHE_RS14060	COG0110	maltose O-acetyltransferase activity
CTHE_RS14085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CTHE_RS14085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CTHE_RS14090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CTHE_RS14100	COG2337	Toxic component of a toxin-antitoxin (TA) module
CTHE_RS14115	COG0438	transferase activity, transferring glycosyl groups
CTHE_RS14120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CTHE_RS14125	COG3959	Transketolase, thiamine diphosphate binding domain
CTHE_RS14130	COG3958	Transketolase
CTHE_RS14135	COG1131	(ABC) transporter
CTHE_RS14155	COG3949	Membrane
CTHE_RS14170	COG0129	dihydroxy-acid dehydratase activity
CTHE_RS14175	COG0028	Belongs to the TPP enzyme family
CTHE_RS14200	COG0250	Participates in transcription elongation, termination and antitermination
CTHE_RS14205	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CTHE_RS14210	COG0081	regulation of translation
CTHE_RS14215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CTHE_RS14225	COG0085	RNA polymerase activity
CTHE_RS14230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CTHE_RS14235	COG1358	cellular component organization or biogenesis
CTHE_RS14240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CTHE_RS14245	COG0049	tRNA binding
CTHE_RS14250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTHE_RS14255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CTHE_RS14275	COG2720	vancomycin resistance protein
CTHE_RS14285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTHE_RS14290	COG0322	excinuclease ABC activity
CTHE_RS14300	COG0544	peptidyl-prolyl cis-trans isomerase activity
CTHE_RS14305	COG0740	serine-type endopeptidase activity
CTHE_RS14310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CTHE_RS14315	COG1067	ATP-dependent peptidase activity
CTHE_RS14315	COG0470	DNA polymerase III
CTHE_RS14320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CTHE_RS14325	COG0741	lytic transglycosylase activity
CTHE_RS14340	COG0613	PHP domain protein
CTHE_RS14345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CTHE_RS14370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CTHE_RS14390	COG3263	regulation of cellular component size
CTHE_RS14395	COG3708	Transcriptional regulator
CTHE_RS14395	COG2207	Transcriptional regulator
CTHE_RS14400	COG4733	cellulase activity
CTHE_RS14400	COG4447	cellulose binding
CTHE_RS14405	COG5297	Belongs to the glycosyl hydrolase family 6
CTHE_RS14440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CTHE_RS14445	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CTHE_RS14450	COG3547	Transposase (IS116 IS110 IS902 family)
CTHE_RS14470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CTHE_RS14510	COG2911	Protein conserved in bacteria
CTHE_RS14510	COG3266	domain, Protein
CTHE_RS14510	COG1361	Conserved repeat domain
CTHE_RS14515	COG5012	cobalamin binding
CTHE_RS14520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CTHE_RS14545	COG1116	anion transmembrane transporter activity
CTHE_RS14550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTHE_RS14555	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CTHE_RS14565	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CTHE_RS14575	COG0674	pyruvate-flavodoxin oxidoreductase activity
CTHE_RS14580	COG1013	pyruvate-flavodoxin oxidoreductase activity
CTHE_RS14590	COG0251	oxidation-reduction process
CTHE_RS14595	COG0626	cystathionine gamma-synthase activity
CTHE_RS14600	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CTHE_RS14605	COG1151	hydroxylamine reductase activity
CTHE_RS14615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTHE_RS14620	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CTHE_RS14630	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CTHE_RS14635	COG1609	Transcriptional regulator
CTHE_RS14650	COG4124	Belongs to the glycosyl hydrolase 26 family
CTHE_RS14655	COG4733	cellulase activity
CTHE_RS14655	COG4447	cellulose binding
CTHE_RS14665	COG2205	protein histidine kinase activity
CTHE_RS14675	COG3328	transposase activity
CTHE_RS14680	COG0835	chemotaxis
CTHE_RS14685	COG0643	Histidine kinase
CTHE_RS14685	COG0784	Response regulator, receiver
CTHE_RS14685	COG2198	Histidine kinase
CTHE_RS14695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CTHE_RS14700	COG2201	protein-glutamate methylesterase activity
CTHE_RS14750	COG4584	PFAM Integrase catalytic
CTHE_RS14750	COG2390	Transcriptional regulator
CTHE_RS14965	COG1253	flavin adenine dinucleotide binding
CTHE_RS14975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CTHE_RS14985	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CTHE_RS15015	COG0124	histidyl-tRNA synthetase
CTHE_RS15020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CTHE_RS15025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CTHE_RS15030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CTHE_RS15035	COG0131	Imidazoleglycerol-phosphate dehydratase
CTHE_RS15040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CTHE_RS15045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CTHE_RS15050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CTHE_RS15055	COG0107	imidazoleglycerol-phosphate synthase activity
CTHE_RS15070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CTHE_RS15075	COG0459	protein refolding
CTHE_RS15090	COG3858	chitin binding
CTHE_RS15100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CTHE_RS15105	COG1366	Belongs to the anti-sigma-factor antagonist family
CTHE_RS15110	COG2172	sigma factor antagonist activity
CTHE_RS15115	COG1191	sigma factor activity
CTHE_RS15145	COG0051	transcription antitermination factor activity, RNA binding
CTHE_RS15150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CTHE_RS15155	COG0088	Forms part of the polypeptide exit tunnel
CTHE_RS15160	COG0089	rRNA binding
CTHE_RS15165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CTHE_RS15170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CTHE_RS15175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CTHE_RS15180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CTHE_RS15185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CTHE_RS15190	COG0255	Belongs to the universal ribosomal protein uL29 family
CTHE_RS15195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CTHE_RS15200	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CTHE_RS15205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CTHE_RS15210	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CTHE_RS15215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CTHE_RS15220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CTHE_RS15225	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CTHE_RS15230	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CTHE_RS15235	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CTHE_RS15240	COG1841	ribosomal large subunit assembly
CTHE_RS15245	COG0200	Binds to the 23S rRNA
CTHE_RS15250	COG0201	protein transport
CTHE_RS15255	COG0563	adenylate kinase activity
CTHE_RS15270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CTHE_RS15275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CTHE_RS15280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CTHE_RS15285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CTHE_RS15290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CTHE_RS15295	COG0202	RNA polymerase activity
CTHE_RS15300	COG0203	ribosomal protein L17
CTHE_RS15305	COG1122	ATPase activity
CTHE_RS15310	COG2813	Specifically methylates the guanine in position
CTHE_RS15315	COG1122	ATPase activity
CTHE_RS15320	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CTHE_RS15325	COG1940	carbohydrate kinase activity
CTHE_RS15330	COG0101	tRNA pseudouridine synthase activity
CTHE_RS15335	COG1329	Transcriptional regulator
CTHE_RS15340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CTHE_RS15345	COG4555	ABC transporter
CTHE_RS15350	COG1668	transmembrane transport
CTHE_RS15355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTHE_RS15355	COG4191	Histidine kinase
CTHE_RS15360	COG3290	protein histidine kinase activity
CTHE_RS15365	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CTHE_RS15370	COG0442	prolyl-tRNA aminoacylation
CTHE_RS15375	COG2340	Cysteine-rich secretory protein family
CTHE_RS15380	COG2273	Hydrolase Family 16
CTHE_RS15385	COG3250	beta-galactosidase activity
CTHE_RS15420	COG3328	transposase activity
CTHE_RS15440	COG4166	transmembrane transport
CTHE_RS15445	COG4608	Belongs to the ABC transporter superfamily
CTHE_RS15450	COG0444	Belongs to the ABC transporter superfamily
CTHE_RS15455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTHE_RS15460	COG0601	transmembrane transport
CTHE_RS15480	COG1725	Transcriptional regulator
CTHE_RS15485	COG1131	(ABC) transporter
CTHE_RS15500	COG1489	DNA binding
CTHE_RS15505	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CTHE_RS15510	COG1191	sigma factor activity
CTHE_RS15550	COG0840	transmembrane signaling receptor activity
CTHE_RS15605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CTHE_RS15635	COG0693	protein deglycase activity
CTHE_RS15645	COG1132	(ABC) transporter
CTHE_RS15655	COG0306	phosphate transporter
CTHE_RS15675	COG1388	LysM domain
CTHE_RS15710	COG5520	Belongs to the glycosyl hydrolase 30 family
CTHE_RS15720	COG0409	Hydrogenase expression formation protein
CTHE_RS15730	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CTHE_RS15750	COG3261	NADH dehydrogenase
CTHE_RS15750	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CTHE_RS15760	COG3260	NADH ubiquinone oxidoreductase 20
CTHE_RS15770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CTHE_RS15770	COG2111	Na H antiporter
CTHE_RS15775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CTHE_RS15785	COG0372	Belongs to the citrate synthase family
CTHE_RS15790	COG0076	glutamate decarboxylase activity
CTHE_RS15795	COG0835	chemotaxis
CTHE_RS15800	COG0840	transmembrane signaling receptor activity
CTHE_RS15825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CTHE_RS15830	COG0840	transmembrane signaling receptor activity
CTHE_RS15865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CTHE_RS15885	COG0768	penicillin binding
CTHE_RS15890	COG2003	Belongs to the UPF0758 family
CTHE_RS15905	COG3328	transposase activity
CTHE_RS15945	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CTHE_RS15965	COG3458	cephalosporin-C deacetylase activity
CTHE_RS15995	COG1131	(ABC) transporter
CTHE_RS16005	COG5002	protein histidine kinase activity
CTHE_RS16010	COG0745	RESPONSE REGULATOR receiver
CTHE_RS16025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CTHE_RS16030	COG0561	phosphatase activity
CTHE_RS16035	COG2304	oxidoreductase activity
CTHE_RS16045	COG2911	Protein conserved in bacteria
CTHE_RS16060	COG1361	Conserved repeat domain
CTHE_RS16065	COG1361	Conserved repeat domain
CTHE_RS16085	COG0116	Belongs to the methyltransferase superfamily
CTHE_RS16095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CTHE_RS16115	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CTHE_RS16130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CTHE_RS16160	COG0463	Glycosyl transferase, family 2
CTHE_RS16175	COG0463	Glycosyl transferase, family 2
CTHE_RS16185	COG1216	Glycosyl transferase, family 2
CTHE_RS16190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CTHE_RS16195	COG0436	Aminotransferase
CTHE_RS16200	COG1316	TRANSCRIPTIONal
CTHE_RS16215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CTHE_RS16220	COG0720	synthase
CTHE_RS16225	COG0602	queuosine metabolic process
CTHE_RS16230	COG1573	uracil-dna glycosylase
CTHE_RS16235	COG1573	uracil-dna glycosylase
CTHE_RS16265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CTHE_RS16275	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CTHE_RS16280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CTHE_RS16295	COG1482	cell wall glycoprotein biosynthetic process
CTHE_RS16305	COG2703	oxygen carrier activity
CTHE_RS16310	COG1773	rubredoxin
CTHE_RS16310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CTHE_RS16335	COG0318	PFAM AMP-dependent synthetase and ligase
CTHE_RS16345	COG1051	belongs to the nudix hydrolase family
CTHE_RS16345	COG1056	cytidyltransferase-related domain
CTHE_RS16360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CTHE_RS16375	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CTHE_RS16380	COG2267	carboxylic ester hydrolase activity
CTHE_RS16415	COG3401	FG-GAP repeat protein
CTHE_RS16415	COG2755	lipolytic protein G-D-S-L family
CTHE_RS16430	COG2207	Transcriptional regulator
CTHE_RS16430	COG3708	Transcriptional regulator
CTHE_RS16445	COG1132	(ABC) transporter
CTHE_RS16450	COG1132	(ABC) transporter
CTHE_RS16455	COG2195	Cleaves the N-terminal amino acid of tripeptides
CTHE_RS16470	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CTHE_RS16490	COG0840	transmembrane signaling receptor activity
CTHE_RS16495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTHE_RS16500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CTHE_RS16505	COG1802	Transcriptional regulator
CTHE_RS16510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CTHE_RS16510	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CTHE_RS16515	COG1187	pseudouridine synthase activity
CTHE_RS16540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTHE_RS16545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTHE_RS16550	COG1597	lipid kinase activity
CTHE_RS16560	COG1136	(ABC) transporter
CTHE_RS16570	COG1136	(ABC) transporter
CTHE_RS16570	COG0577	efflux transmembrane transporter activity
CTHE_RS16590	COG2323	membrane
CTHE_RS16610	COG1686	Belongs to the peptidase S11 family
CTHE_RS16630	COG0569	domain protein
CTHE_RS16665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CTHE_RS16710	COG0628	permease
CTHE_RS16715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CTHE_RS16750	COG3328	transposase activity
CTHE_RS16795	COG3328	transposase activity
CTHE_RS16990	COG3266	domain, Protein
CTHE_RS16990	COG2911	Protein conserved in bacteria
CTHE_RS16990	COG1361	Conserved repeat domain
CTHE_RS17020	COG0745	RESPONSE REGULATOR receiver
CTHE_RS17060	COG0539	negative regulation of cytoplasmic translation
CTHE_RS17060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CTHE_RS17140	COG2140	Oxalate decarboxylase
CTHE_RS17535	COG1361	Conserved repeat domain
CTHE_RS17960	COG0653	protein targeting
CTHE_RS18030	COG2140	Oxalate decarboxylase
CTHE_RS18065	COG0832	Belongs to the urease beta subunit family
CTHE_RS18070	COG0831	urea catabolic process
CTHE_RS18265	COG1376	ErfK ybiS ycfS ynhG family protein