locus-tag	class	description
CLO1313_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLO1313_RS00015	COG0592	DNA-directed DNA polymerase activity
CLO1313_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLO1313_RS00035	COG0187	DNA topoisomerase II activity
CLO1313_RS00040	COG1192	Involved in chromosome partitioning
CLO1313_RS00045	COG1475	DNA binding
CLO1313_RS00060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLO1313_RS00075	COG2814	Major facilitator Superfamily
CLO1313_RS00085	COG2373	Large extracellular alpha-helical protein
CLO1313_RS00095	COG2720	vancomycin resistance protein
CLO1313_RS00115	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLO1313_RS00125	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLO1313_RS00130	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLO1313_RS00160	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CLO1313_RS00180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLO1313_RS00185	COG1802	Transcriptional regulator
CLO1313_RS00190	COG2608	mercury ion transmembrane transporter activity
CLO1313_RS00200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLO1313_RS00225	COG4717	serine-type aminopeptidase activity
CLO1313_RS00230	COG0791	NLP P60 protein
CLO1313_RS00250	COG2959	enzyme of heme biosynthesis
CLO1313_RS00275	COG1078	dGTPase activity
CLO1313_RS00310	COG3872	metal-dependent enzyme
CLO1313_RS00315	COG2890	protein-(glutamine-N5) methyltransferase activity
CLO1313_RS00325	COG4656	Part of a membrane complex involved in electron transport
CLO1313_RS00330	COG4658	electron transport chain
CLO1313_RS00335	COG4659	FMN binding
CLO1313_RS00340	COG4660	Part of a membrane complex involved in electron transport
CLO1313_RS00345	COG4657	Part of a membrane complex involved in electron transport
CLO1313_RS00350	COG2878	Part of a membrane complex involved in electron transport
CLO1313_RS00375	COG1349	DNA-binding transcription factor activity
CLO1313_RS00380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLO1313_RS00385	COG3959	Transketolase, thiamine diphosphate binding domain
CLO1313_RS00390	COG3958	Transketolase
CLO1313_RS00395	COG1063	alcohol dehydrogenase
CLO1313_RS00400	COG1879	ABC-type sugar transport system periplasmic component
CLO1313_RS00405	COG1129	ABC transporter
CLO1313_RS00415	COG0406	alpha-ribazole phosphatase activity
CLO1313_RS00425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLO1313_RS00430	COG1164	Oligoendopeptidase f
CLO1313_RS00440	COG3693	PFAM glycoside hydrolase, family 10
CLO1313_RS00450	COG0590	tRNA wobble adenosine to inosine editing
CLO1313_RS00465	COG0662	Cupin 2, conserved barrel domain protein
CLO1313_RS00475	COG1609	Transcriptional regulator
CLO1313_RS00505	COG0668	transmembrane transport
CLO1313_RS00515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLO1313_RS00525	COG0590	tRNA wobble adenosine to inosine editing
CLO1313_RS00530	COG0028	Belongs to the TPP enzyme family
CLO1313_RS00535	COG0440	acetolactate synthase activity
CLO1313_RS00540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLO1313_RS00545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLO1313_RS00555	COG1191	sigma factor activity
CLO1313_RS00570	COG1959	2 iron, 2 sulfur cluster binding
CLO1313_RS00575	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLO1313_RS00585	COG0181	hydroxymethylbilane synthase activity
CLO1313_RS00595	COG0113	porphobilinogen synthase activity
CLO1313_RS00600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLO1313_RS00605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CLO1313_RS00610	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CLO1313_RS00615	COG4208	sulfate ABC transporter
CLO1313_RS00625	COG0175	sulfate reduction
CLO1313_RS00630	COG0175	sulfate reduction
CLO1313_RS00645	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLO1313_RS00670	COG1595	DNA-templated transcription, initiation
CLO1313_RS00700	COG3534	alpha-L-arabinofuranosidase
CLO1313_RS00705	COG5297	Belongs to the glycosyl hydrolase family 6
CLO1313_RS00715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLO1313_RS00725	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLO1313_RS00740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLO1313_RS00745	COG1216	Glycosyl transferase, family 2
CLO1313_RS00750	COG1088	dTDP-glucose 4,6-dehydratase activity
CLO1313_RS00760	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CLO1313_RS00780	COG3328	transposase activity
CLO1313_RS00790	COG1032	radical SAM domain protein
CLO1313_RS00830	COG1116	anion transmembrane transporter activity
CLO1313_RS00835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLO1313_RS00840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLO1313_RS00850	COG2954	triphosphatase activity
CLO1313_RS00870	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLO1313_RS00875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CLO1313_RS00880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLO1313_RS00890	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLO1313_RS00890	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLO1313_RS00905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLO1313_RS00915	COG3693	PFAM glycoside hydrolase, family 10
CLO1313_RS00930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLO1313_RS00935	COG0428	transporter
CLO1313_RS00940	COG0009	L-threonylcarbamoyladenylate synthase
CLO1313_RS00950	COG0698	ribose 5-phosphate isomerase
CLO1313_RS00955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLO1313_RS00960	COG2131	deaminase
CLO1313_RS00965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLO1313_RS00970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLO1313_RS00975	COG0356	it plays a direct role in the translocation of protons across the membrane
CLO1313_RS00980	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLO1313_RS00985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLO1313_RS00990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLO1313_RS00995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLO1313_RS01000	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLO1313_RS01005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLO1313_RS01010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLO1313_RS01030	COG2911	Protein conserved in bacteria
CLO1313_RS01030	COG1361	Conserved repeat domain
CLO1313_RS01030	COG3266	domain, Protein
CLO1313_RS01040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLO1313_RS01045	COG2385	sporulation resulting in formation of a cellular spore
CLO1313_RS01055	COG1609	Transcriptional regulator
CLO1313_RS01065	COG4786	Flagellar basal body rod
CLO1313_RS01090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLO1313_RS01095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLO1313_RS01100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLO1313_RS01105	COG2088	sporulation resulting in formation of a cellular spore
CLO1313_RS01110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLO1313_RS01120	COG0193	aminoacyl-tRNA hydrolase activity
CLO1313_RS01125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLO1313_RS01130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLO1313_RS01135	COG1917	Cupin 2, conserved barrel domain protein
CLO1313_RS01135	COG2207	Transcriptional regulator
CLO1313_RS01140	COG0259	pyridoxamine-phosphate oxidase activity
CLO1313_RS01145	COG0728	peptidoglycan biosynthetic process
CLO1313_RS01165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLO1313_RS01170	COG2089	acid synthase
CLO1313_RS01180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLO1313_RS01185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLO1313_RS01190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLO1313_RS01200	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLO1313_RS01205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLO1313_RS01235	COG4464	protein tyrosine phosphatase activity
CLO1313_RS01240	COG2002	toxin-antitoxin pair type II binding
CLO1313_RS01245	COG3956	TIGRFAM MazG family protein
CLO1313_RS01255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLO1313_RS01275	COG1098	S1 RNA binding domain
CLO1313_RS01295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CLO1313_RS01370	COG3852	Histidine kinase
CLO1313_RS01385	COG0793	Belongs to the peptidase S41A family
CLO1313_RS01430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLO1313_RS01435	COG0849	cell division
CLO1313_RS01440	COG1607	acyl-coa hydrolase
CLO1313_RS01445	COG2244	polysaccharide biosynthetic process
CLO1313_RS01450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLO1313_RS01460	COG0110	maltose O-acetyltransferase activity
CLO1313_RS01485	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLO1313_RS01485	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLO1313_RS01490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLO1313_RS01495	COG0864	Transcriptional regulator
CLO1313_RS01500	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLO1313_RS01515	COG0438	transferase activity, transferring glycosyl groups
CLO1313_RS01520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLO1313_RS01525	COG3959	Transketolase, thiamine diphosphate binding domain
CLO1313_RS01530	COG3958	Transketolase
CLO1313_RS01535	COG1131	(ABC) transporter
CLO1313_RS01555	COG3949	Membrane
CLO1313_RS01570	COG0129	dihydroxy-acid dehydratase activity
CLO1313_RS01575	COG0028	Belongs to the TPP enzyme family
CLO1313_RS01590	COG0250	Participates in transcription elongation, termination and antitermination
CLO1313_RS01595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLO1313_RS01600	COG0081	regulation of translation
CLO1313_RS01605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLO1313_RS01615	COG0085	RNA polymerase activity
CLO1313_RS01620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLO1313_RS01625	COG1358	cellular component organization or biogenesis
CLO1313_RS01630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLO1313_RS01635	COG0049	tRNA binding
CLO1313_RS01640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLO1313_RS01645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLO1313_RS01665	COG2720	vancomycin resistance protein
CLO1313_RS01675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLO1313_RS01680	COG0322	excinuclease ABC activity
CLO1313_RS01690	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLO1313_RS01695	COG0740	serine-type endopeptidase activity
CLO1313_RS01700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLO1313_RS01705	COG0470	DNA polymerase III
CLO1313_RS01705	COG1067	ATP-dependent peptidase activity
CLO1313_RS01710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLO1313_RS01715	COG0741	lytic transglycosylase activity
CLO1313_RS01730	COG0613	PHP domain protein
CLO1313_RS01735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLO1313_RS01750	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLO1313_RS01770	COG3263	regulation of cellular component size
CLO1313_RS01775	COG3708	Transcriptional regulator
CLO1313_RS01775	COG2207	Transcriptional regulator
CLO1313_RS01780	COG4733	cellulase activity
CLO1313_RS01780	COG4447	cellulose binding
CLO1313_RS01785	COG5297	Belongs to the glycosyl hydrolase family 6
CLO1313_RS01820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CLO1313_RS01825	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CLO1313_RS01835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLO1313_RS01880	COG1361	Conserved repeat domain
CLO1313_RS01880	COG2911	Protein conserved in bacteria
CLO1313_RS01880	COG3266	domain, Protein
CLO1313_RS01885	COG5012	cobalamin binding
CLO1313_RS01890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLO1313_RS01915	COG1116	anion transmembrane transporter activity
CLO1313_RS01920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLO1313_RS01925	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CLO1313_RS01930	COG0436	Aminotransferase
CLO1313_RS01935	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLO1313_RS01945	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLO1313_RS01950	COG1013	pyruvate-flavodoxin oxidoreductase activity
CLO1313_RS01960	COG0251	oxidation-reduction process
CLO1313_RS01965	COG0626	cystathionine gamma-synthase activity
CLO1313_RS01970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CLO1313_RS01975	COG1151	hydroxylamine reductase activity
CLO1313_RS01985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLO1313_RS01990	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CLO1313_RS02000	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLO1313_RS02005	COG1609	Transcriptional regulator
CLO1313_RS02020	COG4124	Belongs to the glycosyl hydrolase 26 family
CLO1313_RS02025	COG4733	cellulase activity
CLO1313_RS02025	COG4447	cellulose binding
CLO1313_RS02035	COG2205	protein histidine kinase activity
CLO1313_RS02045	COG0835	chemotaxis
CLO1313_RS02050	COG2198	Histidine kinase
CLO1313_RS02050	COG0643	Histidine kinase
CLO1313_RS02050	COG0784	Response regulator, receiver
CLO1313_RS02060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLO1313_RS02065	COG2201	protein-glutamate methylesterase activity
CLO1313_RS02075	COG1253	flavin adenine dinucleotide binding
CLO1313_RS02085	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLO1313_RS02095	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CLO1313_RS02125	COG0124	histidyl-tRNA synthetase
CLO1313_RS02130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLO1313_RS02135	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLO1313_RS02140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLO1313_RS02145	COG0131	Imidazoleglycerol-phosphate dehydratase
CLO1313_RS02150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLO1313_RS02155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLO1313_RS02160	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLO1313_RS02165	COG0107	imidazoleglycerol-phosphate synthase activity
CLO1313_RS02180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLO1313_RS02185	COG0459	protein refolding
CLO1313_RS02200	COG3858	chitin binding
CLO1313_RS02210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLO1313_RS02215	COG1366	Belongs to the anti-sigma-factor antagonist family
CLO1313_RS02225	COG1191	sigma factor activity
CLO1313_RS02255	COG0051	transcription antitermination factor activity, RNA binding
CLO1313_RS02260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLO1313_RS02265	COG0088	Forms part of the polypeptide exit tunnel
CLO1313_RS02270	COG0089	rRNA binding
CLO1313_RS02275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLO1313_RS02280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLO1313_RS02285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLO1313_RS02290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLO1313_RS02295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLO1313_RS02300	COG0255	Belongs to the universal ribosomal protein uL29 family
CLO1313_RS02305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLO1313_RS02310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLO1313_RS02315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLO1313_RS02320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLO1313_RS02325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLO1313_RS02330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLO1313_RS02335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLO1313_RS02340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLO1313_RS02345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLO1313_RS02350	COG1841	ribosomal large subunit assembly
CLO1313_RS02355	COG0200	Binds to the 23S rRNA
CLO1313_RS02360	COG0201	protein transport
CLO1313_RS02365	COG0563	adenylate kinase activity
CLO1313_RS02380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLO1313_RS02385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLO1313_RS02390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLO1313_RS02395	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLO1313_RS02400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLO1313_RS02405	COG0202	RNA polymerase activity
CLO1313_RS02410	COG0203	ribosomal protein L17
CLO1313_RS02415	COG1122	ATPase activity
CLO1313_RS02420	COG2813	Specifically methylates the guanine in position
CLO1313_RS02465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLO1313_RS02470	COG1122	ATPase activity
CLO1313_RS02475	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLO1313_RS02480	COG1940	carbohydrate kinase activity
CLO1313_RS02485	COG0101	tRNA pseudouridine synthase activity
CLO1313_RS02490	COG1329	Transcriptional regulator
CLO1313_RS02495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLO1313_RS02500	COG4555	ABC transporter
CLO1313_RS02505	COG1668	transmembrane transport
CLO1313_RS02510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLO1313_RS02510	COG4191	Histidine kinase
CLO1313_RS02515	COG3290	protein histidine kinase activity
CLO1313_RS02520	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLO1313_RS02525	COG0442	prolyl-tRNA aminoacylation
CLO1313_RS02530	COG2340	Cysteine-rich secretory protein family
CLO1313_RS02535	COG2273	Hydrolase Family 16
CLO1313_RS02540	COG3250	beta-galactosidase activity
CLO1313_RS02610	COG4166	transmembrane transport
CLO1313_RS02615	COG4608	Belongs to the ABC transporter superfamily
CLO1313_RS02620	COG0444	Belongs to the ABC transporter superfamily
CLO1313_RS02625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLO1313_RS02630	COG0601	transmembrane transport
CLO1313_RS02650	COG1725	Transcriptional regulator
CLO1313_RS02655	COG1131	(ABC) transporter
CLO1313_RS02675	COG1489	DNA binding
CLO1313_RS02680	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CLO1313_RS02685	COG1191	sigma factor activity
CLO1313_RS02725	COG0840	transmembrane signaling receptor activity
CLO1313_RS02775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLO1313_RS02805	COG0693	protein deglycase activity
CLO1313_RS02815	COG1132	(ABC) transporter
CLO1313_RS02825	COG0306	phosphate transporter
CLO1313_RS02845	COG1388	LysM domain
CLO1313_RS02880	COG5520	Belongs to the glycosyl hydrolase 30 family
CLO1313_RS02890	COG0409	Hydrogenase expression formation protein
CLO1313_RS02900	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CLO1313_RS02915	COG3261	NADH dehydrogenase
CLO1313_RS02915	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CLO1313_RS02925	COG3260	NADH ubiquinone oxidoreductase 20
CLO1313_RS02935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLO1313_RS02935	COG2111	Na H antiporter
CLO1313_RS02940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLO1313_RS02945	COG0372	Belongs to the citrate synthase family
CLO1313_RS02950	COG0076	glutamate decarboxylase activity
CLO1313_RS02955	COG0835	chemotaxis
CLO1313_RS02960	COG0840	transmembrane signaling receptor activity
CLO1313_RS02985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLO1313_RS02990	COG0840	transmembrane signaling receptor activity
CLO1313_RS03025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLO1313_RS03045	COG0768	penicillin binding
CLO1313_RS03050	COG2003	Belongs to the UPF0758 family
CLO1313_RS03065	COG3328	transposase activity
CLO1313_RS03110	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
CLO1313_RS03130	COG3458	cephalosporin-C deacetylase activity
CLO1313_RS03160	COG1131	(ABC) transporter
CLO1313_RS03170	COG5002	protein histidine kinase activity
CLO1313_RS03175	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS03190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLO1313_RS03195	COG0561	phosphatase activity
CLO1313_RS03200	COG2304	oxidoreductase activity
CLO1313_RS03210	COG2911	Protein conserved in bacteria
CLO1313_RS03220	COG1361	Conserved repeat domain
CLO1313_RS03225	COG1361	Conserved repeat domain
CLO1313_RS03245	COG0116	Belongs to the methyltransferase superfamily
CLO1313_RS03255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLO1313_RS03275	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CLO1313_RS03290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLO1313_RS03325	COG0463	Glycosyl transferase, family 2
CLO1313_RS03340	COG0463	Glycosyl transferase, family 2
CLO1313_RS03350	COG1216	Glycosyl transferase, family 2
CLO1313_RS03355	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLO1313_RS03360	COG0436	Aminotransferase
CLO1313_RS03365	COG1316	TRANSCRIPTIONal
CLO1313_RS03380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLO1313_RS03385	COG0720	synthase
CLO1313_RS03390	COG0602	queuosine metabolic process
CLO1313_RS03395	COG1573	uracil-dna glycosylase
CLO1313_RS03400	COG1573	uracil-dna glycosylase
CLO1313_RS03430	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLO1313_RS03445	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CLO1313_RS03450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CLO1313_RS03465	COG1482	cell wall glycoprotein biosynthetic process
CLO1313_RS03475	COG2703	oxygen carrier activity
CLO1313_RS03480	COG1773	rubredoxin
CLO1313_RS03480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLO1313_RS03495	COG1361	Conserved repeat domain
CLO1313_RS03505	COG0318	PFAM AMP-dependent synthetase and ligase
CLO1313_RS03515	COG1051	belongs to the nudix hydrolase family
CLO1313_RS03515	COG1056	cytidyltransferase-related domain
CLO1313_RS03530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CLO1313_RS03545	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CLO1313_RS03550	COG2267	carboxylic ester hydrolase activity
CLO1313_RS03565	COG1404	Belongs to the peptidase S8 family
CLO1313_RS03585	COG2755	lipolytic protein G-D-S-L family
CLO1313_RS03585	COG3401	FG-GAP repeat protein
CLO1313_RS03600	COG3708	Transcriptional regulator
CLO1313_RS03600	COG2207	Transcriptional regulator
CLO1313_RS03615	COG1132	(ABC) transporter
CLO1313_RS03620	COG1132	(ABC) transporter
CLO1313_RS03625	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLO1313_RS03640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CLO1313_RS03660	COG0840	transmembrane signaling receptor activity
CLO1313_RS03665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLO1313_RS03670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLO1313_RS03675	COG1802	Transcriptional regulator
CLO1313_RS03680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLO1313_RS03680	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CLO1313_RS03685	COG1187	pseudouridine synthase activity
CLO1313_RS03710	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLO1313_RS03715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLO1313_RS03720	COG1597	lipid kinase activity
CLO1313_RS03730	COG1136	(ABC) transporter
CLO1313_RS03740	COG0577	efflux transmembrane transporter activity
CLO1313_RS03740	COG1136	(ABC) transporter
CLO1313_RS03760	COG2323	membrane
CLO1313_RS03780	COG1686	Belongs to the peptidase S11 family
CLO1313_RS03790	COG0569	domain protein
CLO1313_RS03870	COG0628	permease
CLO1313_RS03875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLO1313_RS03960	COG3328	transposase activity
CLO1313_RS04035	COG3328	transposase activity
CLO1313_RS04060	COG3328	transposase activity
CLO1313_RS04065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLO1313_RS04065	COG0723	plastoquinol--plastocyanin reductase activity
CLO1313_RS04085	COG1126	abc transporter atp-binding protein
CLO1313_RS04135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLO1313_RS04175	COG1595	DNA-templated transcription, initiation
CLO1313_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
CLO1313_RS04235	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CLO1313_RS04240	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CLO1313_RS04250	COG0628	permease
CLO1313_RS04260	COG1714	RDD family
CLO1313_RS04265	COG0616	signal peptide processing
CLO1313_RS04270	COG1971	Probably functions as a manganese efflux pump
CLO1313_RS04285	COG1131	(ABC) transporter
CLO1313_RS04300	COG0133	tryptophan synthase activity
CLO1313_RS04305	COG0159	tryptophan synthase activity
CLO1313_RS04310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLO1313_RS04315	COG5002	protein histidine kinase activity
CLO1313_RS04320	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS04335	COG5337	Spore coat protein CotH
CLO1313_RS04340	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLO1313_RS04350	COG1321	iron dependent repressor
CLO1313_RS04370	COG4447	cellulose binding
CLO1313_RS04375	COG1442	glycosyl transferase family 8
CLO1313_RS04380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLO1313_RS04385	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS04390	COG5002	protein histidine kinase activity
CLO1313_RS04395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLO1313_RS04400	COG2267	carboxylic ester hydrolase activity
CLO1313_RS04405	COG0617	tRNA 3'-terminal CCA addition
CLO1313_RS04415	COG4496	protein, YerC YecD
CLO1313_RS04430	COG0653	protein targeting
CLO1313_RS04435	COG0285	dihydrofolate synthase activity
CLO1313_RS04445	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLO1313_RS04455	COG2201	protein-glutamate methylesterase activity
CLO1313_RS04460	COG0673	inositol 2-dehydrogenase activity
CLO1313_RS04465	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLO1313_RS04465	COG2199	diguanylate cyclase activity
CLO1313_RS04470	COG4492	Belongs to the UPF0735 family
CLO1313_RS04475	COG0460	homoserine dehydrogenase
CLO1313_RS04480	COG0527	aspartate kinase activity
CLO1313_RS04525	COG0537	adenosine 5'-monophosphoramidase activity
CLO1313_RS04530	COG1361	Conserved repeat domain
CLO1313_RS04540	COG4464	protein tyrosine phosphatase activity
CLO1313_RS04560	COG0489	protein tyrosine kinase activity
CLO1313_RS04600	COG1216	Glycosyl transferase, family 2
CLO1313_RS04615	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CLO1313_RS04625	COG0629	single-stranded DNA binding
CLO1313_RS04630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLO1313_RS04635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLO1313_RS04645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLO1313_RS04645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLO1313_RS04650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLO1313_RS04655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLO1313_RS04660	COG1490	D-aminoacyl-tRNA deacylase activity
CLO1313_RS04665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLO1313_RS04670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLO1313_RS04720	COG0124	histidyl-tRNA synthetase
CLO1313_RS04725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLO1313_RS04755	COG0481	GTPase activity
CLO1313_RS04760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLO1313_RS04765	COG1420	regulation of RNA biosynthetic process
CLO1313_RS04770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLO1313_RS04775	COG0443	Heat shock 70 kDa protein
CLO1313_RS04780	COG0484	heat shock protein binding
CLO1313_RS04785	COG2264	protein methyltransferase activity
CLO1313_RS04790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLO1313_RS04795	COG2201	protein-glutamate methylesterase activity
CLO1313_RS04805	COG1561	YicC-like family, N-terminal region
CLO1313_RS04810	COG2052	Domain of unknown function (DUF370)
CLO1313_RS04815	COG0194	GDP metabolic process
CLO1313_RS04820	COG1758	RNA polymerase activity
CLO1313_RS04825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLO1313_RS04830	COG0423	glycine-tRNA ligase activity
CLO1313_RS04835	COG3290	protein histidine kinase activity
CLO1313_RS04845	COG0535	radical SAM domain protein
CLO1313_RS04850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLO1313_RS04850	COG0574	Belongs to the PEP-utilizing enzyme family
CLO1313_RS04855	COG3693	PFAM glycoside hydrolase, family 10
CLO1313_RS04870	COG0662	Cupin 2, conserved barrel domain protein
CLO1313_RS04875	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CLO1313_RS04885	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLO1313_RS04890	COG1323	Belongs to the UPF0348 family
CLO1313_RS04910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CLO1313_RS04920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLO1313_RS04935	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
CLO1313_RS04955	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS04960	COG5002	protein histidine kinase activity
CLO1313_RS04960	COG3850	Histidine kinase
CLO1313_RS04965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLO1313_RS04970	COG2199	diguanylate cyclase activity
CLO1313_RS04970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLO1313_RS04975	COG0297	glycogen (starch) synthase activity
CLO1313_RS04980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLO1313_RS04995	COG2261	transglycosylase associated protein
CLO1313_RS05000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLO1313_RS05005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLO1313_RS05010	COG0742	ribosomal rna small subunit methyltransferase
CLO1313_RS05015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLO1313_RS05025	COG3314	Sporulation integral membrane protein YlbJ
CLO1313_RS05030	COG2755	lipolytic protein G-D-S-L family
CLO1313_RS05035	COG1191	sigma factor activity
CLO1313_RS05040	COG3507	Belongs to the glycosyl hydrolase 43 family
CLO1313_RS05060	COG2197	response regulator
CLO1313_RS05065	COG0840	transmembrane signaling receptor activity
CLO1313_RS05070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLO1313_RS05090	COG0205	6-phosphofructokinase activity
CLO1313_RS05115	COG1472	Belongs to the glycosyl hydrolase 3 family
CLO1313_RS05135	COG2252	PERMEase
CLO1313_RS05140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLO1313_RS05145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLO1313_RS05150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLO1313_RS05155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLO1313_RS05160	COG0138	bifunctional purine biosynthesis protein purh
CLO1313_RS05165	COG0151	Belongs to the GarS family
CLO1313_RS05170	COG1216	Glycosyl transferase, family 2
CLO1313_RS05180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLO1313_RS05185	COG1713	HD superfamily hydrolase involved in NAD metabolism
CLO1313_RS05195	COG0799	negative regulation of ribosome biogenesis
CLO1313_RS05200	COG0495	leucyl-tRNA aminoacylation
CLO1313_RS05210	COG0840	transmembrane signaling receptor activity
CLO1313_RS05220	COG1022	Amp-dependent synthetase and ligase
CLO1313_RS05225	COG1686	Belongs to the peptidase S11 family
CLO1313_RS05230	COG1555	photosystem II stabilization
CLO1313_RS05230	COG1596	polysaccharide export
CLO1313_RS05240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLO1313_RS05255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CLO1313_RS05260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLO1313_RS05265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLO1313_RS05270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLO1313_RS05275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLO1313_RS05280	COG3459	Glycosyltransferase 36 associated
CLO1313_RS05295	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CLO1313_RS05300	COG0542	response to heat
CLO1313_RS05305	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CLO1313_RS05310	COG0730	response to heat
CLO1313_RS05330	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CLO1313_RS05355	COG2766	serine protein kinase
CLO1313_RS05360	COG2718	Belongs to the UPF0229 family
CLO1313_RS05365	COG2719	SpoVR family
CLO1313_RS05380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CLO1313_RS05385	COG0402	S-adenosylhomocysteine deaminase activity
CLO1313_RS05425	COG3328	transposase activity
CLO1313_RS05435	COG0546	phosphoglycolate phosphatase activity
CLO1313_RS05445	COG4555	ABC transporter
CLO1313_RS05460	COG0657	acetylesterase activity
CLO1313_RS05475	COG0714	Associated with various cellular activities
CLO1313_RS05485	COG1305	Transglutaminase-like
CLO1313_RS05505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLO1313_RS05510	COG1406	Chemotaxis phosphatase CheX
CLO1313_RS05540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLO1313_RS05550	COG2078	PFAM AMMECR1 domain protein
CLO1313_RS05550	COG3885	ferrous iron binding
CLO1313_RS05560	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CLO1313_RS05570	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CLO1313_RS05575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLO1313_RS05580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLO1313_RS05585	COG0640	Transcriptional regulator
CLO1313_RS05590	COG0798	PFAM Bile acid sodium symporter
CLO1313_RS05620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLO1313_RS05630	COG1459	type II secretion system
CLO1313_RS05670	COG0740	serine-type endopeptidase activity
CLO1313_RS05680	COG1674	ftsk spoiiie
CLO1313_RS05690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLO1313_RS05700	COG1418	mRNA catabolic process
CLO1313_RS05705	COG1692	metallophosphoesterase
CLO1313_RS05710	COG2359	stage V sporulation protein S
CLO1313_RS05730	COG0438	transferase activity, transferring glycosyl groups
CLO1313_RS05740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CLO1313_RS05760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CLO1313_RS05800	COG1702	phosphate starvation-inducible protein PhoH
CLO1313_RS05805	COG1480	7TM receptor with intracellular HD hydrolase
CLO1313_RS05810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLO1313_RS05815	COG0295	cytidine deaminase activity
CLO1313_RS05820	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLO1313_RS05825	COG1381	Involved in DNA repair and RecF pathway recombination
CLO1313_RS05835	COG1104	cysteine desulfurase activity
CLO1313_RS05840	COG0301	tRNA thio-modification
CLO1313_RS05845	COG2720	vancomycin resistance protein
CLO1313_RS05865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLO1313_RS05870	COG1983	PspC domain protein
CLO1313_RS05875	COG1305	Transglutaminase-like
CLO1313_RS05885	COG0714	Associated with various cellular activities
CLO1313_RS05890	COG0039	L-malate dehydrogenase activity
CLO1313_RS05895	COG1546	Belongs to the CinA family
CLO1313_RS05895	COG1058	Belongs to the CinA family
CLO1313_RS05900	COG0728	peptidoglycan biosynthetic process
CLO1313_RS05905	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLO1313_RS05915	COG0705	Rhomboid family
CLO1313_RS05915	COG0457	Tetratricopeptide repeat
CLO1313_RS05955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLO1313_RS05975	COG1466	dna polymerase III delta subunit
CLO1313_RS05980	COG0268	Binds directly to 16S ribosomal RNA
CLO1313_RS06000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLO1313_RS06010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLO1313_RS06015	COG0154	amidase activity
CLO1313_RS06020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLO1313_RS06030	COG0280	phosphate acetyltransferase
CLO1313_RS06035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLO1313_RS06045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLO1313_RS06055	COG1160	GTP binding
CLO1313_RS06065	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLO1313_RS06070	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CLO1313_RS06080	COG1175	transmembrane transport
CLO1313_RS06085	COG0395	ABC-type sugar transport system, permease component
CLO1313_RS06095	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLO1313_RS06095	COG2247	cell wall binding repeat
CLO1313_RS06110	COG1193	negative regulation of DNA recombination
CLO1313_RS06115	COG0628	permease
CLO1313_RS06125	COG0768	penicillin binding
CLO1313_RS06130	COG0826	peptidase U32
CLO1313_RS06135	COG4122	O-methyltransferase activity
CLO1313_RS06140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLO1313_RS06145	COG1217	gtp-binding protein TYPA
CLO1313_RS06150	COG0052	Belongs to the universal ribosomal protein uS2 family
CLO1313_RS06155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLO1313_RS06160	COG0528	UMP kinase activity
CLO1313_RS06165	COG0233	cytoplasmic translational termination
CLO1313_RS06175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLO1313_RS06180	COG0575	Belongs to the CDS family
CLO1313_RS06185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLO1313_RS06195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLO1313_RS06205	COG0779	Required for maturation of 30S ribosomal subunits
CLO1313_RS06210	COG0195	Participates in both transcription termination and antitermination
CLO1313_RS06215	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CLO1313_RS06225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLO1313_RS06230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLO1313_RS06235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CLO1313_RS06240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLO1313_RS06245	COG0196	riboflavin kinase activity
CLO1313_RS06250	COG0612	Peptidase, M16
CLO1313_RS06255	COG0612	Peptidase, M16
CLO1313_RS06260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLO1313_RS06265	COG0772	Belongs to the SEDS family
CLO1313_RS06270	COG2001	Belongs to the MraZ family
CLO1313_RS06275	COG0275	rRNA processing
CLO1313_RS06285	COG0768	penicillin binding
CLO1313_RS06290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLO1313_RS06295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLO1313_RS06300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLO1313_RS06305	COG0772	Belongs to the SEDS family
CLO1313_RS06310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLO1313_RS06315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLO1313_RS06330	COG3328	transposase activity
CLO1313_RS06355	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CLO1313_RS06365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLO1313_RS06370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLO1313_RS06375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLO1313_RS06380	COG2385	sporulation resulting in formation of a cellular spore
CLO1313_RS06380	COG2247	cell wall binding repeat
CLO1313_RS06385	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLO1313_RS06390	COG0343	queuine tRNA-ribosyltransferase activity
CLO1313_RS06395	COG1862	Preprotein translocase
CLO1313_RS06410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLO1313_RS06420	COG0540	Belongs to the ATCase OTCase family
CLO1313_RS06425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CLO1313_RS06440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLO1313_RS06445	COG0543	2 iron, 2 sulfur cluster binding
CLO1313_RS06450	COG0167	dihydroorotate dehydrogenase activity
CLO1313_RS06455	COG0588	phosphoglycerate mutase activity
CLO1313_RS06475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLO1313_RS06480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLO1313_RS06495	COG2030	dehydratase
CLO1313_RS06500	COG0416	fatty acid biosynthetic process
CLO1313_RS06505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLO1313_RS06510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLO1313_RS06515	COG1028	Short-chain dehydrogenase reductase Sdr
CLO1313_RS06520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLO1313_RS06525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLO1313_RS06530	COG0571	ribonuclease III activity
CLO1313_RS06540	COG2359	stage V sporulation protein S
CLO1313_RS06555	COG0552	protein localization to endoplasmic reticulum
CLO1313_RS06575	COG1748	Saccharopine dehydrogenase
CLO1313_RS06610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLO1313_RS06635	COG1496	oxidoreductase activity
CLO1313_RS06645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLO1313_RS06650	COG0564	pseudouridine synthase activity
CLO1313_RS06660	COG1418	mRNA catabolic process
CLO1313_RS06665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLO1313_RS06670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLO1313_RS06675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLO1313_RS06680	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CLO1313_RS06685	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CLO1313_RS06700	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CLO1313_RS06705	COG0358	DNA primase activity
CLO1313_RS06710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLO1313_RS06730	COG2384	SAM-dependent methyltransferase
CLO1313_RS06735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CLO1313_RS06740	COG3437	response regulator, receiver
CLO1313_RS06745	COG1595	DNA-templated transcription, initiation
CLO1313_RS06765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLO1313_RS06765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLO1313_RS06770	COG0237	dephospho-CoA kinase activity
CLO1313_RS06785	COG0697	spore germination
CLO1313_RS06790	COG3706	GGDEF domain
CLO1313_RS06795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLO1313_RS06800	COG0835	chemotaxis
CLO1313_RS06805	COG0012	GTP binding
CLO1313_RS06820	COG0512	Glutamine amidotransferase of anthranilate synthase
CLO1313_RS06820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLO1313_RS06825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLO1313_RS06830	COG0134	indole-3-glycerol-phosphate synthase activity
CLO1313_RS06835	COG0135	phosphoribosylanthranilate isomerase activity
CLO1313_RS06885	COG1316	TRANSCRIPTIONal
CLO1313_RS06900	COG4864	UPF0365 protein
CLO1313_RS06905	COG1030	water channel activity
CLO1313_RS06910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLO1313_RS06915	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CLO1313_RS06920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLO1313_RS06925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLO1313_RS06930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLO1313_RS06940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CLO1313_RS06945	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLO1313_RS06950	COG0006	proline dipeptidase activity
CLO1313_RS06955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLO1313_RS06970	COG3854	ATPases associated with a variety of cellular activities
CLO1313_RS07010	COG1302	Protein conserved in bacteria
CLO1313_RS07025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLO1313_RS07030	COG1570	exodeoxyribonuclease VII activity
CLO1313_RS07035	COG1722	exodeoxyribonuclease VII activity
CLO1313_RS07045	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CLO1313_RS07055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLO1313_RS07060	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CLO1313_RS07070	COG3291	Pkd domain containing protein
CLO1313_RS07095	COG1131	(ABC) transporter
CLO1313_RS07105	COG3706	GGDEF domain
CLO1313_RS07110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLO1313_RS07115	COG1438	arginine binding
CLO1313_RS07120	COG0497	DNA recombination
CLO1313_RS07125	COG0750	zinc metalloprotease
CLO1313_RS07130	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS07135	COG2201	protein-glutamate methylesterase activity
CLO1313_RS07140	COG0643	Histidine kinase
CLO1313_RS07140	COG2198	Histidine kinase
CLO1313_RS07145	COG0835	chemotaxis
CLO1313_RS07155	COG2201	protein-glutamate methylesterase activity
CLO1313_RS07165	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS07175	COG0564	pseudouridine synthase activity
CLO1313_RS07185	COG3328	transposase activity
CLO1313_RS07190	COG5002	protein histidine kinase activity
CLO1313_RS07195	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS07205	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLO1313_RS07205	COG2755	lipolytic protein G-D-S-L family
CLO1313_RS07215	COG0366	Alpha amylase catalytic
CLO1313_RS07220	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CLO1313_RS07230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLO1313_RS07235	COG1799	cell septum assembly
CLO1313_RS07245	COG2302	S4 RNA-binding domain
CLO1313_RS07250	COG3599	regulation of cell shape
CLO1313_RS07260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLO1313_RS07275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLO1313_RS07285	COG0840	transmembrane signaling receptor activity
CLO1313_RS07295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLO1313_RS07300	COG2340	Cysteine-rich secretory protein family
CLO1313_RS07310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLO1313_RS07315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLO1313_RS07320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLO1313_RS07325	COG1923	regulation of RNA biosynthetic process
CLO1313_RS07330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLO1313_RS07340	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CLO1313_RS07345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLO1313_RS07350	COG0228	four-way junction DNA binding
CLO1313_RS07355	COG1837	Belongs to the UPF0109 family
CLO1313_RS07360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLO1313_RS07365	COG0336	Belongs to the RNA methyltransferase TrmD family
CLO1313_RS07370	COG0335	large ribosomal subunit rRNA binding
CLO1313_RS07390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLO1313_RS07405	COG0792	nuclease activity
CLO1313_RS07410	COG2003	Belongs to the UPF0758 family
CLO1313_RS07445	COG3842	ATPase activity
CLO1313_RS07450	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLO1313_RS07470	COG4733	cellulase activity
CLO1313_RS07475	COG3409	Peptidoglycan-binding domain 1 protein
CLO1313_RS07475	COG0793	Belongs to the peptidase S41A family
CLO1313_RS07480	COG0534	Mate efflux family protein
CLO1313_RS07490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLO1313_RS07495	COG2188	Transcriptional regulator
CLO1313_RS07515	COG3266	domain, Protein
CLO1313_RS07515	COG1361	Conserved repeat domain
CLO1313_RS07515	COG2911	Protein conserved in bacteria
CLO1313_RS07520	COG1361	Conserved repeat domain
CLO1313_RS07520	COG2911	Protein conserved in bacteria
CLO1313_RS07520	COG3266	domain, Protein
CLO1313_RS07535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLO1313_RS07550	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CLO1313_RS07555	COG4974	Belongs to the 'phage' integrase family
CLO1313_RS07565	COG1362	aminopeptidase activity
CLO1313_RS07570	COG2199	diguanylate cyclase activity
CLO1313_RS07570	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLO1313_RS07575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLO1313_RS07580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLO1313_RS07585	COG0482	sulfurtransferase activity
CLO1313_RS07590	COG0822	iron-sulfur transferase activity
CLO1313_RS07600	COG1959	2 iron, 2 sulfur cluster binding
CLO1313_RS07610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLO1313_RS07615	COG0105	UTP biosynthetic process
CLO1313_RS07620	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CLO1313_RS07630	COG0204	Acyl-transferase
CLO1313_RS07655	COG2081	HI0933 family
CLO1313_RS07660	COG0406	alpha-ribazole phosphatase activity
CLO1313_RS07665	COG1737	Transcriptional regulator
CLO1313_RS07690	COG0511	ligase activity, forming carbon-carbon bonds
CLO1313_RS07700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CLO1313_RS07710	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CLO1313_RS07715	COG0010	Belongs to the arginase family
CLO1313_RS07720	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLO1313_RS07725	COG1187	pseudouridine synthase activity
CLO1313_RS07730	COG3874	Sporulation protein YtfJ
CLO1313_RS07745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLO1313_RS07750	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLO1313_RS07755	COG0180	Tryptophanyl-tRNA synthetase
CLO1313_RS07760	COG1994	Peptidase M50
CLO1313_RS07765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CLO1313_RS07765	COG3620	sequence-specific DNA binding
CLO1313_RS07765	COG0617	tRNA 3'-terminal CCA addition
CLO1313_RS07780	COG0517	IMP dehydrogenase activity
CLO1313_RS07780	COG0516	GMP reductase activity
CLO1313_RS07790	COG1686	Belongs to the peptidase S11 family
CLO1313_RS07800	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CLO1313_RS07805	COG4974	Belongs to the 'phage' integrase family
CLO1313_RS07810	COG1300	Membrane
CLO1313_RS07820	COG0328	RNA-DNA hybrid ribonuclease activity
CLO1313_RS07825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLO1313_RS07855	COG0697	spore germination
CLO1313_RS07860	COG0330	HflC and HflK could
CLO1313_RS07870	COG3583	domain protein
CLO1313_RS07870	COG3584	3D domain protein
CLO1313_RS07890	COG2273	Hydrolase Family 16
CLO1313_RS07895	COG4447	cellulose binding
CLO1313_RS07920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLO1313_RS07935	COG1942	4-Oxalocrotonate Tautomerase
CLO1313_RS07965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLO1313_RS07990	COG3949	Membrane
CLO1313_RS08010	COG2273	Hydrolase Family 16
CLO1313_RS08015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLO1313_RS08035	COG0631	protein serine/threonine phosphatase activity
CLO1313_RS08040	COG2815	serine threonine protein kinase
CLO1313_RS08040	COG0515	serine threonine protein kinase
CLO1313_RS08090	COG5297	Belongs to the glycosyl hydrolase family 6
CLO1313_RS08100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CLO1313_RS08105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CLO1313_RS08110	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLO1313_RS08115	COG1321	iron dependent repressor
CLO1313_RS08125	COG1918	ferrous iron import across plasma membrane
CLO1313_RS08125	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLO1313_RS08130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLO1313_RS08150	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLO1313_RS08160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CLO1313_RS08165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLO1313_RS08190	COG0791	NLP P60 protein
CLO1313_RS08205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLO1313_RS08210	COG0352	thiamine-phosphate diphosphorylase activity
CLO1313_RS08220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLO1313_RS08225	COG2022	thiamine diphosphate biosynthetic process
CLO1313_RS08230	COG2022	thiamine diphosphate biosynthetic process
CLO1313_RS08230	COG2104	thiamine diphosphate biosynthetic process
CLO1313_RS08235	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLO1313_RS08255	COG2226	methyltransferase
CLO1313_RS08290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLO1313_RS08300	COG1201	RNA secondary structure unwinding
CLO1313_RS08355	COG2204	response regulator
CLO1313_RS08365	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CLO1313_RS08370	COG0436	Aminotransferase
CLO1313_RS08375	COG0778	Nitroreductase
CLO1313_RS08390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLO1313_RS08395	COG1162	GTPase activity
CLO1313_RS08400	COG2815	serine threonine protein kinase
CLO1313_RS08400	COG0515	serine threonine protein kinase
CLO1313_RS08405	COG0631	protein serine/threonine phosphatase activity
CLO1313_RS08410	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLO1313_RS08415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLO1313_RS08415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLO1313_RS08420	COG2738	Putative neutral zinc metallopeptidase
CLO1313_RS08430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLO1313_RS08435	COG0242	peptide deformylase activity
CLO1313_RS08440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLO1313_RS08465	COG1477	protein flavinylation
CLO1313_RS08470	COG1252	NADH dehydrogenase
CLO1313_RS08485	COG0726	polysaccharide deacetylase
CLO1313_RS08490	COG0367	asparagine synthase
CLO1313_RS08495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLO1313_RS08500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLO1313_RS08505	COG0583	DNA-binding transcription factor activity
CLO1313_RS08515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CLO1313_RS08525	COG0326	Molecular chaperone. Has ATPase activity
CLO1313_RS08530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLO1313_RS08535	COG1121	(ABC) transporter
CLO1313_RS08540	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLO1313_RS08545	COG0735	belongs to the Fur family
CLO1313_RS08555	COG0631	protein serine/threonine phosphatase activity
CLO1313_RS08560	COG5297	Belongs to the glycosyl hydrolase family 6
CLO1313_RS08575	COG0577	efflux transmembrane transporter activity
CLO1313_RS08575	COG1136	(ABC) transporter
CLO1313_RS08580	COG1136	(ABC) transporter
CLO1313_RS08585	COG3850	Histidine kinase
CLO1313_RS08585	COG5002	protein histidine kinase activity
CLO1313_RS08590	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS08595	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLO1313_RS08595	COG4447	cellulose binding
CLO1313_RS08605	COG2274	protein secretion by the type I secretion system
CLO1313_RS08655	COG5002	protein histidine kinase activity
CLO1313_RS08660	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CLO1313_RS08675	COG2176	DNA-directed DNA polymerase activity
CLO1313_RS08680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLO1313_RS08690	COG2843	Capsule synthesis protein
CLO1313_RS08725	COG1191	sigma factor activity
CLO1313_RS08735	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CLO1313_RS08740	COG1776	CheC inhibitor of MCP methylation
CLO1313_RS08745	COG0835	chemotaxis
CLO1313_RS08750	COG0643	Histidine kinase
CLO1313_RS08750	COG2198	Histidine kinase
CLO1313_RS08755	COG2201	protein-glutamate methylesterase activity
CLO1313_RS08770	COG1419	protein localization to endoplasmic reticulum
CLO1313_RS08775	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLO1313_RS08780	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLO1313_RS08785	COG1684	flagellar biosynthetic protein fliR
CLO1313_RS08790	COG1987	bacterial-type flagellum assembly
CLO1313_RS08795	COG1338	Plays a role in the flagellum-specific transport system
CLO1313_RS08805	COG2201	protein-glutamate methylesterase activity
CLO1313_RS08810	COG1776	CheC inhibitor of MCP methylation
CLO1313_RS08810	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLO1313_RS08815	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLO1313_RS08825	COG1582	Flagellar protein (FlbD)
CLO1313_RS08840	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLO1313_RS08860	COG1157	protein secretion by the type III secretion system
CLO1313_RS08865	COG1317	bacterial-type flagellum organization
CLO1313_RS08870	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLO1313_RS08880	COG1677	Flagellar hook-basal body complex protein FliE
CLO1313_RS08885	COG1558	bacterial-type flagellum-dependent cell motility
CLO1313_RS08890	COG1815	bacterial-type flagellum-dependent cell motility
CLO1313_RS08895	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CLO1313_RS08900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLO1313_RS08905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLO1313_RS08905	COG0758	DNA mediated transformation
CLO1313_RS08910	COG0708	Exodeoxyribonuclease III
CLO1313_RS08915	COG3304	Inner membrane component domain
CLO1313_RS08925	COG0606	chelatase, subunit chli
CLO1313_RS08950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLO1313_RS08955	COG1873	PFAM PRC-barrel domain
CLO1313_RS08960	COG1191	sigma factor activity
CLO1313_RS08965	COG1191	sigma factor activity
CLO1313_RS08975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CLO1313_RS08980	COG0849	cell division
CLO1313_RS08985	COG3856	small basic protein
CLO1313_RS08990	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CLO1313_RS08995	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLO1313_RS09000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLO1313_RS09005	COG3442	glutamine amidotransferase
CLO1313_RS09015	COG3328	transposase activity
CLO1313_RS09020	COG4447	cellulose binding
CLO1313_RS09055	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CLO1313_RS09095	COG1012	belongs to the aldehyde dehydrogenase family
CLO1313_RS09095	COG1454	alcohol dehydrogenase
CLO1313_RS09100	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CLO1313_RS09105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLO1313_RS09115	COG0612	Peptidase, M16
CLO1313_RS09120	COG1185	polyribonucleotide nucleotidyltransferase activity
CLO1313_RS09125	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLO1313_RS09140	COG3546	catalase activity
CLO1313_RS09150	COG2273	Hydrolase Family 16
CLO1313_RS09150	COG5297	Belongs to the glycosyl hydrolase family 6
CLO1313_RS09160	COG2848	UPF0210 protein
CLO1313_RS09165	COG3830	Belongs to the UPF0237 family
CLO1313_RS09190	COG4447	cellulose binding
CLO1313_RS09195	COG1191	sigma factor activity
CLO1313_RS09220	COG0393	Putative heavy-metal-binding
CLO1313_RS09225	COG1132	(ABC) transporter
CLO1313_RS09230	COG1132	(ABC) transporter
CLO1313_RS09235	COG1869	D-ribose catabolic process
CLO1313_RS09250	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLO1313_RS09255	COG1129	ABC transporter
CLO1313_RS09260	COG1940	carbohydrate kinase activity
CLO1313_RS09265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLO1313_RS09270	COG1063	alcohol dehydrogenase
CLO1313_RS09280	COG0577	efflux transmembrane transporter activity
CLO1313_RS09280	COG1136	(ABC) transporter
CLO1313_RS09330	COG0519	Catalyzes the synthesis of GMP from XMP
CLO1313_RS09335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLO1313_RS09350	COG3328	transposase activity
CLO1313_RS09360	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CLO1313_RS09365	COG1691	(AIR) carboxylase
CLO1313_RS09370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLO1313_RS09385	COG3620	sequence-specific DNA binding
CLO1313_RS09395	COG0436	Aminotransferase
CLO1313_RS09400	COG1522	sequence-specific DNA binding
CLO1313_RS09410	COG3118	belongs to the thioredoxin family
CLO1313_RS09420	COG3328	transposase activity
CLO1313_RS09450	COG1379	DNA repair
CLO1313_RS09455	COG1924	4 iron, 4 sulfur cluster binding
CLO1313_RS09470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLO1313_RS09475	COG0681	Belongs to the peptidase S26 family
CLO1313_RS09480	COG0191	fructose-bisphosphate aldolase activity
CLO1313_RS09485	COG0205	6-phosphofructokinase activity
CLO1313_RS09495	COG0039	L-malate dehydrogenase activity
CLO1313_RS09500	COG0281	malic enzyme
CLO1313_RS09525	COG0784	Response regulator, receiver
CLO1313_RS09525	COG2205	protein histidine kinase activity
CLO1313_RS09560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLO1313_RS09585	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLO1313_RS09590	COG1361	Conserved repeat domain
CLO1313_RS09590	COG3266	domain, Protein
CLO1313_RS09590	COG2911	Protein conserved in bacteria
CLO1313_RS09620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLO1313_RS09620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLO1313_RS09625	COG0525	valine-tRNA ligase activity
CLO1313_RS09635	COG1472	Belongs to the glycosyl hydrolase 3 family
CLO1313_RS09655	COG1376	ErfK ybiS ycfS ynhG family protein
CLO1313_RS09665	COG2133	pyrroloquinoline quinone binding
CLO1313_RS09665	COG5183	chlorophyll binding
CLO1313_RS09670	COG1191	sigma factor activity
CLO1313_RS09685	COG0542	response to heat
CLO1313_RS09700	COG3583	domain protein
CLO1313_RS09700	COG3584	3D domain protein
CLO1313_RS09705	COG0556	nucleotide-excision repair
CLO1313_RS09720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLO1313_RS09725	COG0187	DNA topoisomerase II activity
CLO1313_RS09745	COG2966	Psort location CytoplasmicMembrane, score
CLO1313_RS09750	COG2340	Cysteine-rich secretory protein family
CLO1313_RS09755	COG0534	Mate efflux family protein
CLO1313_RS09760	COG0840	transmembrane signaling receptor activity
CLO1313_RS09810	COG1331	Highly conserved protein containing a thioredoxin domain
CLO1313_RS09815	COG0460	homoserine dehydrogenase
CLO1313_RS09820	COG1199	ATP-dependent helicase activity
CLO1313_RS09825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLO1313_RS09835	COG2205	protein histidine kinase activity
CLO1313_RS09840	COG0538	isocitrate dehydrogenase activity
CLO1313_RS09850	COG0667	Aldo Keto reductase
CLO1313_RS09855	COG0297	glycogen (starch) synthase activity
CLO1313_RS09870	COG0564	pseudouridine synthase activity
CLO1313_RS09875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLO1313_RS09875	COG0116	Belongs to the methyltransferase superfamily
CLO1313_RS09880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLO1313_RS09885	COG3459	Glycosyltransferase 36 associated
CLO1313_RS09890	COG4733	cellulase activity
CLO1313_RS09890	COG4447	cellulose binding
CLO1313_RS09895	COG2199	diguanylate cyclase activity
CLO1313_RS09895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLO1313_RS09900	COG1686	Belongs to the peptidase S11 family
CLO1313_RS09905	COG4733	cellulase activity
CLO1313_RS09905	COG4447	cellulose binding
CLO1313_RS09915	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CLO1313_RS09920	COG1191	sigma factor activity
CLO1313_RS09925	COG4447	cellulose binding
CLO1313_RS09930	COG0840	transmembrane signaling receptor activity
CLO1313_RS09935	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CLO1313_RS09950	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLO1313_RS09960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLO1313_RS09970	COG4447	cellulose binding
CLO1313_RS09980	COG1609	Transcriptional regulator
CLO1313_RS09995	COG0714	Associated with various cellular activities
CLO1313_RS10010	COG1690	Belongs to the RtcB family
CLO1313_RS10025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLO1313_RS10030	COG3401	FG-GAP repeat protein
CLO1313_RS10040	COG2217	Heavy metal translocating P-type atpase
CLO1313_RS10045	COG3409	Peptidoglycan-binding domain 1 protein
CLO1313_RS10045	COG3773	Cell wall hydrolase
CLO1313_RS10065	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CLO1313_RS10080	COG0667	Aldo Keto reductase
CLO1313_RS10090	COG0318	PFAM AMP-dependent synthetase and ligase
CLO1313_RS10095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLO1313_RS10105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLO1313_RS10150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLO1313_RS10165	COG3328	transposase activity
CLO1313_RS10195	COG1408	metallophosphoesterase
CLO1313_RS10200	COG0166	Belongs to the GPI family
CLO1313_RS10210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLO1313_RS10210	COG0072	phenylalanine-tRNA ligase activity
CLO1313_RS10215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLO1313_RS10225	COG2723	6-phospho-beta-galactosidase activity
CLO1313_RS10235	COG2273	Hydrolase Family 16
CLO1313_RS10240	COG1609	Transcriptional regulator
CLO1313_RS10245	COG1215	transferase activity, transferring glycosyl groups
CLO1313_RS10255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLO1313_RS10255	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLO1313_RS10295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLO1313_RS10300	COG0493	'glutamate synthase
CLO1313_RS10300	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLO1313_RS10305	COG0069	glutamate synthase activity
CLO1313_RS10310	COG0067	glutamate synthase
CLO1313_RS10330	COG0475	glutathione-regulated potassium exporter activity
CLO1313_RS10345	COG2273	Hydrolase Family 16
CLO1313_RS10350	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CLO1313_RS10355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLO1313_RS10360	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CLO1313_RS10365	COG5401	PFAM Sporulation and spore germination
CLO1313_RS10370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLO1313_RS10375	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLO1313_RS10385	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLO1313_RS10390	COG2255	four-way junction helicase activity
CLO1313_RS10395	COG0632	four-way junction helicase activity
CLO1313_RS10400	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CLO1313_RS10405	COG0137	argininosuccinate synthase activity
CLO1313_RS10410	COG0165	Argininosuccinate lyase
CLO1313_RS10430	COG1368	sulfuric ester hydrolase activity
CLO1313_RS10435	COG0493	'glutamate synthase
CLO1313_RS10435	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CLO1313_RS10465	COG2201	protein-glutamate methylesterase activity
CLO1313_RS10470	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLO1313_RS10480	COG1534	Rna-binding protein
CLO1313_RS10490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLO1313_RS10495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLO1313_RS10505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLO1313_RS10525	COG1470	cell adhesion involved in biofilm formation
CLO1313_RS10530	COG3906	Belongs to the UPF0473 family
CLO1313_RS10535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLO1313_RS10540	COG0667	Aldo Keto reductase
CLO1313_RS10545	COG4472	Bacterial protein of unknown function (DUF965)
CLO1313_RS10550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLO1313_RS10560	COG1683	Conserved Protein
CLO1313_RS10565	COG0557	exoribonuclease II activity
CLO1313_RS10585	COG0148	phosphopyruvate hydratase activity
CLO1313_RS10590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLO1313_RS10590	COG2199	diguanylate cyclase activity
CLO1313_RS10600	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CLO1313_RS10605	COG0149	triose-phosphate isomerase activity
CLO1313_RS10610	COG0126	phosphoglycerate kinase activity
CLO1313_RS10635	COG0318	PFAM AMP-dependent synthetase and ligase
CLO1313_RS10640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLO1313_RS10645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLO1313_RS10650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLO1313_RS10705	COG1366	Belongs to the anti-sigma-factor antagonist family
CLO1313_RS10710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLO1313_RS10715	COG1481	regulation of sporulation
CLO1313_RS10725	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CLO1313_RS10730	COG1660	Displays ATPase and GTPase activities
CLO1313_RS10735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLO1313_RS10740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLO1313_RS10745	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CLO1313_RS10770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLO1313_RS10790	COG0432	Pfam Uncharacterised protein family UPF0047
CLO1313_RS10795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLO1313_RS10800	COG1979	alcohol dehydrogenase
CLO1313_RS10810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLO1313_RS10820	COG0739	heme binding
CLO1313_RS10830	COG1803	Methylglyoxal synthase
CLO1313_RS10835	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLO1313_RS10840	COG2894	cell division
CLO1313_RS10845	COG0850	regulation of cytokinetic process
CLO1313_RS10850	COG0768	penicillin binding
CLO1313_RS10865	COG1077	Cell shape determining protein MreB Mrl
CLO1313_RS10870	COG0424	maF-like protein
CLO1313_RS10895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLO1313_RS10900	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLO1313_RS10905	COG0835	chemotaxis
CLO1313_RS10950	COG4447	cellulose binding
CLO1313_RS10950	COG5297	Belongs to the glycosyl hydrolase family 6
CLO1313_RS10955	COG0017	Asparaginyl-tRNA synthetase
CLO1313_RS10960	COG2502	aspartate--ammonia ligase
CLO1313_RS10965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLO1313_RS10985	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLO1313_RS10995	COG1368	sulfuric ester hydrolase activity
CLO1313_RS11000	COG1268	BioY protein
CLO1313_RS11005	COG0653	protein targeting
CLO1313_RS11010	COG4447	cellulose binding
CLO1313_RS11015	COG1191	sigma factor activity
CLO1313_RS11035	COG1649	PFAM Uncharacterised BCR, COG1649
CLO1313_RS11040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLO1313_RS11085	COG2382	esterase
CLO1313_RS11085	COG3507	Belongs to the glycosyl hydrolase 43 family
CLO1313_RS11085	COG3693	PFAM glycoside hydrolase, family 10
CLO1313_RS11090	COG4733	cellulase activity
CLO1313_RS11090	COG4447	cellulose binding
CLO1313_RS11095	COG1160	GTP binding
CLO1313_RS11105	COG4447	cellulose binding
CLO1313_RS11105	COG4733	cellulase activity
CLO1313_RS11110	COG0840	transmembrane signaling receptor activity
CLO1313_RS11115	COG0835	chemotaxis
CLO1313_RS11120	COG0840	transmembrane signaling receptor activity
CLO1313_RS11125	COG0835	chemotaxis
CLO1313_RS11135	COG1151	hydroxylamine reductase activity
CLO1313_RS11155	COG4124	Belongs to the glycosyl hydrolase 26 family
CLO1313_RS11185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CLO1313_RS11190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CLO1313_RS11200	COG4106	trans-aconitate 2-methyltransferase activity
CLO1313_RS11205	COG2267	carboxylic ester hydrolase activity
CLO1313_RS11210	COG0156	8-amino-7-oxononanoate synthase activity
CLO1313_RS11215	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CLO1313_RS11220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLO1313_RS11245	COG3507	Belongs to the glycosyl hydrolase 43 family
CLO1313_RS11300	COG3328	transposase activity
CLO1313_RS11320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLO1313_RS11340	COG1595	DNA-templated transcription, initiation
CLO1313_RS11350	COG4124	Belongs to the glycosyl hydrolase 26 family
CLO1313_RS11350	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLO1313_RS11370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLO1313_RS11380	COG0717	Belongs to the dCTP deaminase family
CLO1313_RS11395	COG2409	Drug exporters of the RND superfamily
CLO1313_RS11405	COG0561	phosphatase activity
CLO1313_RS11420	COG0426	domain, Protein
CLO1313_RS11420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLO1313_RS11425	COG0494	nUDIX hydrolase
CLO1313_RS11435	COG0840	transmembrane signaling receptor activity
CLO1313_RS11460	COG1695	Transcriptional regulator
CLO1313_RS11480	COG0840	transmembrane signaling receptor activity
CLO1313_RS11485	COG0004	ammonium transporteR
CLO1313_RS11490	COG1132	(ABC) transporter
CLO1313_RS11495	COG1132	(ABC) transporter
CLO1313_RS11515	COG1361	Conserved repeat domain
CLO1313_RS11530	COG1393	Belongs to the ArsC family
CLO1313_RS11635	COG0577	efflux transmembrane transporter activity
CLO1313_RS11640	COG1136	(ABC) transporter
CLO1313_RS11645	COG2205	protein histidine kinase activity
CLO1313_RS11650	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS11685	COG1131	(ABC) transporter
CLO1313_RS11695	COG3620	sequence-specific DNA binding
CLO1313_RS11705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLO1313_RS11710	COG0154	amidase activity
CLO1313_RS11720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLO1313_RS11745	COG1024	Enoyl-CoA hydratase
CLO1313_RS11750	COG4106	trans-aconitate 2-methyltransferase activity
CLO1313_RS11780	COG1464	Belongs to the NlpA lipoprotein family
CLO1313_RS11785	COG2011	ABC-type metal ion transport system permease component
CLO1313_RS11790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLO1313_RS11800	COG0626	cystathionine gamma-synthase activity
CLO1313_RS11805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLO1313_RS11845	COG0535	radical SAM domain protein
CLO1313_RS11850	COG2873	o-acetylhomoserine
CLO1313_RS11855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLO1313_RS11860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLO1313_RS11870	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CLO1313_RS11880	COG0813	purine-nucleoside phosphorylase activity
CLO1313_RS11885	COG1744	ABC transporter substrate-binding protein PnrA-like
CLO1313_RS11890	COG1328	CTP reductase activity
CLO1313_RS11895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLO1313_RS11900	COG3845	ABC transporter
CLO1313_RS11905	COG4603	Belongs to the binding-protein-dependent transport system permease family
CLO1313_RS11910	COG1079	Belongs to the binding-protein-dependent transport system permease family
CLO1313_RS11915	COG0295	cytidine deaminase activity
CLO1313_RS11925	COG4753	response regulator
CLO1313_RS11925	COG2207	Transcriptional regulator
CLO1313_RS11940	COG3842	ATPase activity
CLO1313_RS11990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLO1313_RS12040	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CLO1313_RS12060	COG3409	Peptidoglycan-binding domain 1 protein
CLO1313_RS12060	COG5632	N-Acetylmuramoyl-L-alanine amidase
CLO1313_RS12140	COG0740	serine-type endopeptidase activity
CLO1313_RS12145	COG4695	Portal protein
CLO1313_RS12150	COG1802	Transcriptional regulator
CLO1313_RS12150	COG4626	Terminase
CLO1313_RS12225	COG1136	(ABC) transporter
CLO1313_RS12235	COG2205	protein histidine kinase activity
CLO1313_RS12240	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS12285	COG1120	ATPase activity
CLO1313_RS12290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLO1313_RS12295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLO1313_RS12305	COG0739	heme binding
CLO1313_RS12325	COG0577	efflux transmembrane transporter activity
CLO1313_RS12335	COG1136	(ABC) transporter
CLO1313_RS12375	COG1592	Rubrerythrin
CLO1313_RS12385	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CLO1313_RS12390	COG1067	ATP-dependent peptidase activity
CLO1313_RS12395	COG0456	acetyltransferase
CLO1313_RS12400	COG1214	PFAM Peptidase M22, glycoprotease
CLO1313_RS12405	COG0802	atpase or kinase
CLO1313_RS12410	COG1228	amidohydrolase
CLO1313_RS12435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLO1313_RS12440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLO1313_RS12450	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CLO1313_RS12455	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLO1313_RS12465	COG1215	transferase activity, transferring glycosyl groups
CLO1313_RS12470	COG0542	response to heat
CLO1313_RS12475	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CLO1313_RS12480	COG3880	PFAM UvrB UvrC protein
CLO1313_RS12505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLO1313_RS12510	COG0287	Prephenate dehydrogenase
CLO1313_RS12515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLO1313_RS12520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CLO1313_RS12525	COG0488	(ABC) transporter
CLO1313_RS12535	COG1122	ATPase activity
CLO1313_RS12545	COG0310	cobalt ion transport
CLO1313_RS12550	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLO1313_RS12555	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS12580	COG1595	DNA-templated transcription, initiation
CLO1313_RS12595	COG0829	nickel cation binding
CLO1313_RS12600	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CLO1313_RS12615	COG0804	urea catabolic process
CLO1313_RS12655	COG2207	Transcriptional regulator
CLO1313_RS12655	COG4753	response regulator
CLO1313_RS12665	COG4251	negative regulation of phosphorylation
CLO1313_RS12705	COG3328	transposase activity
CLO1313_RS12830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLO1313_RS12840	COG1606	tRNA processing
CLO1313_RS12850	COG1959	2 iron, 2 sulfur cluster binding
CLO1313_RS12855	COG1959	2 iron, 2 sulfur cluster binding
CLO1313_RS12860	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CLO1313_RS12865	COG5002	protein histidine kinase activity
CLO1313_RS12870	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS12875	COG2217	Heavy metal translocating P-type atpase
CLO1313_RS12920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLO1313_RS12925	COG1278	Cold shock
CLO1313_RS12930	COG3695	enzyme binding
CLO1313_RS12945	COG0793	Belongs to the peptidase S41A family
CLO1313_RS12945	COG3409	Peptidoglycan-binding domain 1 protein
CLO1313_RS12955	COG2177	Part of the ABC transporter FtsEX involved in
CLO1313_RS12960	COG2884	Cell division ATP-binding protein ftsE
CLO1313_RS12965	COG3835	regulator
CLO1313_RS12970	COG3842	ATPase activity
CLO1313_RS12975	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLO1313_RS12980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLO1313_RS12990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLO1313_RS12995	COG0505	Belongs to the CarA family
CLO1313_RS13000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLO1313_RS13005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLO1313_RS13020	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CLO1313_RS13040	COG1695	Transcriptional regulator
CLO1313_RS13045	COG1408	metallophosphoesterase
CLO1313_RS13060	COG1876	peptidase activity
CLO1313_RS13070	COG3328	transposase activity
CLO1313_RS13080	COG0726	polysaccharide deacetylase
CLO1313_RS13100	COG3321	synthase
CLO1313_RS13100	COG1028	Short-chain dehydrogenase reductase Sdr
CLO1313_RS13100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLO1313_RS13100	COG0318	PFAM AMP-dependent synthetase and ligase
CLO1313_RS13100	COG0300	oxidoreductase activity
CLO1313_RS13145	COG5002	protein histidine kinase activity
CLO1313_RS13150	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS13155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLO1313_RS13160	COG1982	Orn Lys Arg decarboxylase major
CLO1313_RS13165	COG1285	pathogenesis
CLO1313_RS13175	COG1695	Transcriptional regulator
CLO1313_RS13185	COG0504	CTP synthase activity
CLO1313_RS13210	COG3409	Peptidoglycan-binding domain 1 protein
CLO1313_RS13210	COG0793	Belongs to the peptidase S41A family
CLO1313_RS13225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLO1313_RS13235	COG0018	arginyl-trna synthetase
CLO1313_RS13245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLO1313_RS13250	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLO1313_RS13255	COG2239	Acts as a magnesium transporter
CLO1313_RS13275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLO1313_RS13280	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CLO1313_RS13285	COG0492	ferredoxin-NADP+ reductase activity
CLO1313_RS13295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLO1313_RS13300	COG0785	Cytochrome C biogenesis protein
CLO1313_RS13335	COG2183	response to ionizing radiation
CLO1313_RS13360	COG2226	methyltransferase
CLO1313_RS13370	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CLO1313_RS13380	COG2382	esterase
CLO1313_RS13380	COG3507	Belongs to the glycosyl hydrolase 43 family
CLO1313_RS13380	COG3693	PFAM glycoside hydrolase, family 10
CLO1313_RS13385	COG3634	alkyl hydroperoxide reductase activity
CLO1313_RS13390	COG0450	alkyl hydroperoxide reductase
CLO1313_RS13400	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLO1313_RS13635	COG0457	Tetratricopeptide repeat
CLO1313_RS13635	COG0515	serine threonine protein kinase
CLO1313_RS13640	COG2226	methyltransferase
CLO1313_RS13645	COG2226	methyltransferase
CLO1313_RS13670	COG1074	ATP-dependent DNA helicase activity
CLO1313_RS13675	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CLO1313_RS13785	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CLO1313_RS13810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLO1313_RS13820	COG0697	spore germination
CLO1313_RS13835	COG0215	cysteine-tRNA ligase activity
CLO1313_RS13840	COG1045	serine acetyltransferase
CLO1313_RS13875	COG1473	amidohydrolase
CLO1313_RS13880	COG2155	Conserved Protein
CLO1313_RS13885	COG0217	transcriptional regulatory protein
CLO1313_RS13890	COG5002	protein histidine kinase activity
CLO1313_RS13900	COG1739	Uncharacterized protein family UPF0029
CLO1313_RS13905	COG0681	Belongs to the peptidase S26 family
CLO1313_RS13910	COG0494	nUDIX hydrolase
CLO1313_RS13915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLO1313_RS13925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLO1313_RS13935	COG0756	dUTP diphosphatase activity
CLO1313_RS13940	COG0826	peptidase U32
CLO1313_RS13945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CLO1313_RS13955	COG5297	Belongs to the glycosyl hydrolase family 6
CLO1313_RS13975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLO1313_RS13980	COG3583	domain protein
CLO1313_RS13980	COG3584	3D domain protein
CLO1313_RS13990	COG0084	hydrolase, TatD family'
CLO1313_RS13995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLO1313_RS13995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLO1313_RS14005	COG0700	Nucleoside recognition
CLO1313_RS14010	COG2715	membrane protein required for spore maturation
CLO1313_RS14015	COG2002	toxin-antitoxin pair type II binding
CLO1313_RS14020	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLO1313_RS14025	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CLO1313_RS14035	COG1774	PSP1 C-terminal conserved region
CLO1313_RS14040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLO1313_RS14045	COG1728	Protein conserved in bacteria
CLO1313_RS14055	COG1982	Orn Lys Arg decarboxylase major
CLO1313_RS14070	COG1136	(ABC) transporter
CLO1313_RS14085	COG5002	protein histidine kinase activity
CLO1313_RS14095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLO1313_RS14100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLO1313_RS14110	COG3693	PFAM glycoside hydrolase, family 10
CLO1313_RS14115	COG1191	sigma factor activity
CLO1313_RS14140	COG0395	ABC-type sugar transport system, permease component
CLO1313_RS14145	COG1175	transmembrane transport
CLO1313_RS14150	COG0714	Associated with various cellular activities
CLO1313_RS14195	COG3940	Belongs to the glycosyl hydrolase 43 family
CLO1313_RS14200	COG3940	Belongs to the glycosyl hydrolase 43 family
CLO1313_RS14215	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CLO1313_RS14220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CLO1313_RS14225	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLO1313_RS14230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLO1313_RS14285	COG1361	Conserved repeat domain
CLO1313_RS14320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLO1313_RS14330	COG1773	rubredoxin
CLO1313_RS14355	COG1408	metallophosphoesterase
CLO1313_RS14370	COG0254	rRNA binding
CLO1313_RS14375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLO1313_RS14440	COG0038	chloride channel
CLO1313_RS14450	COG0037	tRNA processing
CLO1313_RS14460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLO1313_RS14465	COG1295	ribonuclease BN
CLO1313_RS14470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLO1313_RS14475	COG0629	single-stranded DNA binding
CLO1313_RS14480	COG0360	Binds together with S18 to 16S ribosomal RNA
CLO1313_RS14490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLO1313_RS14495	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLO1313_RS14510	COG2382	esterase
CLO1313_RS14510	COG3507	Belongs to the glycosyl hydrolase 43 family
CLO1313_RS14510	COG3693	PFAM glycoside hydrolase, family 10
CLO1313_RS14515	COG3507	Belongs to the glycosyl hydrolase 43 family
CLO1313_RS14520	COG2382	esterase
CLO1313_RS14520	COG3507	Belongs to the glycosyl hydrolase 43 family
CLO1313_RS14520	COG3693	PFAM glycoside hydrolase, family 10
CLO1313_RS14525	COG2382	esterase
CLO1313_RS14525	COG3507	Belongs to the glycosyl hydrolase 43 family
CLO1313_RS14525	COG3693	PFAM glycoside hydrolase, family 10
CLO1313_RS14530	COG3507	Belongs to the glycosyl hydrolase 43 family
CLO1313_RS14535	COG3250	beta-galactosidase activity
CLO1313_RS14550	COG0789	Transcriptional regulator
CLO1313_RS14550	COG4978	Transcriptional regulator
CLO1313_RS14555	COG0577	efflux transmembrane transporter activity
CLO1313_RS14560	COG1136	(ABC) transporter
CLO1313_RS14565	COG5002	protein histidine kinase activity
CLO1313_RS14570	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS14615	COG0302	gtp cyclohydrolase
CLO1313_RS14620	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLO1313_RS14620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLO1313_RS14625	COG4242	Belongs to the peptidase S51 family
CLO1313_RS14635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLO1313_RS14640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLO1313_RS14645	COG0473	3-isopropylmalate dehydrogenase activity
CLO1313_RS14650	COG0066	3-isopropylmalate dehydratase activity
CLO1313_RS14655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLO1313_RS14660	COG2207	Transcriptional regulator
CLO1313_RS14665	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CLO1313_RS14690	COG1516	flagellar protein fliS
CLO1313_RS14695	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLO1313_RS14705	COG1088	dTDP-glucose 4,6-dehydratase activity
CLO1313_RS14710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLO1313_RS14725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLO1313_RS14740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLO1313_RS14750	COG2089	acid synthase
CLO1313_RS14755	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CLO1313_RS14760	COG2226	methyltransferase
CLO1313_RS14765	COG1086	Polysaccharide biosynthesis protein
CLO1313_RS14785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLO1313_RS14790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLO1313_RS14800	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CLO1313_RS14805	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CLO1313_RS14815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLO1313_RS14820	COG1256	bacterial-type flagellum assembly
CLO1313_RS14820	COG4786	Flagellar basal body rod
CLO1313_RS14845	COG1040	competence protein
CLO1313_RS14850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLO1313_RS14860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLO1313_RS14870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLO1313_RS14875	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CLO1313_RS14880	COG0037	tRNA processing
CLO1313_RS14885	COG0305	Participates in initiation and elongation during chromosome replication
CLO1313_RS14890	COG0359	binds to the 23S rRNA
CLO1313_RS14895	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CLO1313_RS14905	COG0077	Prephenate dehydratase
CLO1313_RS14905	COG1605	Chorismate mutase
CLO1313_RS14915	COG1269	ATP hydrolysis coupled proton transport
CLO1313_RS14920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLO1313_RS14925	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CLO1313_RS14940	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CLO1313_RS14945	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CLO1313_RS14950	COG1394	ATPase activity, coupled to movement of substances
CLO1313_RS14955	COG0488	(ABC) transporter
CLO1313_RS14990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLO1313_RS15005	COG0765	amino acid transport
CLO1313_RS15015	COG2201	protein-glutamate methylesterase activity
CLO1313_RS15020	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLO1313_RS15030	COG2198	Histidine kinase
CLO1313_RS15030	COG0643	Histidine kinase
CLO1313_RS15035	COG0835	chemotaxis
CLO1313_RS15040	COG0582	viral genome integration into host DNA
CLO1313_RS15045	COG2207	Transcriptional regulator
CLO1313_RS15045	COG3708	Transcriptional regulator
CLO1313_RS15060	COG1131	(ABC) transporter
CLO1313_RS15080	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CLO1313_RS15085	COG1518	maintenance of DNA repeat elements
CLO1313_RS15125	COG1968	undecaprenyl-diphosphatase activity
CLO1313_RS15130	COG0534	Mate efflux family protein
CLO1313_RS15180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLO1313_RS15185	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLO1313_RS15190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLO1313_RS15210	COG5002	protein histidine kinase activity
CLO1313_RS15215	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS15240	COG0438	transferase activity, transferring glycosyl groups
CLO1313_RS15250	COG0438	transferase activity, transferring glycosyl groups
CLO1313_RS15280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLO1313_RS15285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLO1313_RS15300	COG1361	Conserved repeat domain
CLO1313_RS15310	COG3773	Cell wall hydrolase
CLO1313_RS15320	COG0517	IMP dehydrogenase activity
CLO1313_RS15335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CLO1313_RS15340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CLO1313_RS15375	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CLO1313_RS15380	COG4447	cellulose binding
CLO1313_RS15380	COG4733	cellulase activity
CLO1313_RS15385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLO1313_RS15390	COG1475	DNA binding
CLO1313_RS15395	COG0357	Ribosomal RNA small subunit methyltransferase G
CLO1313_RS15405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLO1313_RS15410	COG1847	R3H domain protein
CLO1313_RS15415	COG0706	membrane insertase activity
CLO1313_RS15420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLO1313_RS15430	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CLO1313_RS15440	COG2911	Protein conserved in bacteria
CLO1313_RS15440	COG1361	Conserved repeat domain
CLO1313_RS15440	COG3266	domain, Protein
CLO1313_RS15600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLO1313_RS15600	COG0539	negative regulation of cytoplasmic translation
CLO1313_RS15640	COG0745	RESPONSE REGULATOR receiver
CLO1313_RS15695	COG2140	Oxalate decarboxylase
CLO1313_RS15955	COG4251	negative regulation of phosphorylation
CLO1313_RS16115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLO1313_RS16170	COG1376	ErfK ybiS ycfS ynhG family protein
CLO1313_RS16300	COG2140	Oxalate decarboxylase
CLO1313_RS16325	COG0832	Belongs to the urease beta subunit family
CLO1313_RS16330	COG0831	urea catabolic process