locus-tag	class	description
APA03_RS00015	COG0582	viral genome integration into host DNA
APA03_RS00020	COG1671	Belongs to the UPF0178 family
APA03_RS00030	COG2814	Major facilitator Superfamily
APA03_RS00040	COG2835	tetraacyldisaccharide 4'-kinase activity
APA03_RS00045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APA03_RS00055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APA03_RS00080	COG0778	Nitroreductase
APA03_RS00090	COG0456	acetyltransferase
APA03_RS00115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APA03_RS00120	COG1012	belongs to the aldehyde dehydrogenase family
APA03_RS00130	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APA03_RS00145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APA03_RS00155	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APA03_RS00165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APA03_RS00180	COG0126	phosphoglycerate kinase activity
APA03_RS00190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APA03_RS00200	COG0156	8-amino-7-oxononanoate synthase activity
APA03_RS00205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APA03_RS00210	COG0405	Gamma-glutamyltransferase
APA03_RS00230	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
APA03_RS00240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APA03_RS00255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APA03_RS00260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APA03_RS00265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APA03_RS00275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APA03_RS00285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APA03_RS00290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APA03_RS00295	COG0539	negative regulation of cytoplasmic translation
APA03_RS00310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APA03_RS00315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APA03_RS00320	COG1420	regulation of RNA biosynthetic process
APA03_RS00325	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APA03_RS00360	COG0772	Belongs to the SEDS family
APA03_RS00365	COG0768	penicillin binding
APA03_RS00385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APA03_RS00390	COG1612	heme a metabolic process
APA03_RS00400	COG2814	Major facilitator Superfamily
APA03_RS00410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APA03_RS00415	COG1289	transmembrane transporter activity
APA03_RS00425	COG1573	uracil-dna glycosylase
APA03_RS00445	COG0670	Belongs to the BI1 family
APA03_RS00470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APA03_RS00490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APA03_RS00505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APA03_RS00525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APA03_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
APA03_RS00550	COG0586	Pfam SNARE associated Golgi protein
APA03_RS00560	COG0281	malic enzyme
APA03_RS00590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APA03_RS00595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APA03_RS00600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APA03_RS00605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APA03_RS00610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APA03_RS00615	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APA03_RS00620	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APA03_RS00625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APA03_RS00640	COG1113	amino acid transport
APA03_RS00645	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APA03_RS00650	COG4208	sulfate ABC transporter
APA03_RS00680	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APA03_RS00685	COG2207	Transcriptional regulator
APA03_RS00690	COG4303	Ethanolamine ammonia lyase large subunit
APA03_RS00695	COG4302	ethanolamine ammonia-lyase activity
APA03_RS00705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APA03_RS00720	COG1278	Cold shock
APA03_RS00775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APA03_RS00785	COG2205	protein histidine kinase activity
APA03_RS00785	COG0784	Response regulator, receiver
APA03_RS00810	COG1137	ATPase activity
APA03_RS00875	COG0515	serine threonine protein kinase
APA03_RS00875	COG2815	serine threonine protein kinase
APA03_RS00890	COG4372	Transposase
APA03_RS00900	COG2963	transposase activity
APA03_RS00920	COG2983	Belongs to the UPF0260 family
APA03_RS00935	COG3842	ATPase activity
APA03_RS00960	COG1566	PFAM secretion protein HlyD family protein
APA03_RS00980	COG1657	PFAM Prenyltransferase squalene oxidase
APA03_RS00985	COG1233	COG1233 Phytoene dehydrogenase and related
APA03_RS00990	COG1562	ergosterol biosynthetic process
APA03_RS00995	COG1562	ergosterol biosynthetic process
APA03_RS01005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APA03_RS01015	COG0287	Prephenate dehydrogenase
APA03_RS01035	COG0450	alkyl hydroperoxide reductase
APA03_RS01040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APA03_RS01055	COG3384	dioxygenase
APA03_RS01060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APA03_RS01070	COG0488	(ABC) transporter
APA03_RS01090	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APA03_RS01100	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APA03_RS01105	COG0343	queuine tRNA-ribosyltransferase activity
APA03_RS01110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APA03_RS01120	COG1881	PFAM PEBP family protein
APA03_RS01135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APA03_RS01150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APA03_RS01180	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
APA03_RS01185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APA03_RS01200	COG0667	Aldo Keto reductase
APA03_RS01210	COG0556	nucleotide-excision repair
APA03_RS01220	COG0612	Peptidase, M16
APA03_RS01255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APA03_RS01270	COG0167	dihydroorotate dehydrogenase activity
APA03_RS01285	COG1692	metallophosphoesterase
APA03_RS01290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APA03_RS01315	COG0352	thiamine-phosphate diphosphorylase activity
APA03_RS01390	COG1509	lysine 2,3-aminomutase activity
APA03_RS01400	COG0024	Methionine aminopeptidase
APA03_RS01405	COG1686	Belongs to the peptidase S11 family
APA03_RS01410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APA03_RS01425	COG2326	polyphosphate kinase activity
APA03_RS01430	COG1678	Uncharacterized ACR, COG1678
APA03_RS01435	COG1660	Displays ATPase and GTPase activities
APA03_RS01445	COG2205	protein histidine kinase activity
APA03_RS01450	COG0745	RESPONSE REGULATOR receiver
APA03_RS01455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APA03_RS01460	COG0443	Heat shock 70 kDa protein
APA03_RS01465	COG0484	heat shock protein binding
APA03_RS01470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APA03_RS01475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APA03_RS01480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APA03_RS01485	COG0138	bifunctional purine biosynthesis protein purh
APA03_RS01500	COG0697	spore germination
APA03_RS01510	COG0752	glycyl-tRNA synthetase alpha subunit
APA03_RS01520	COG1396	sequence-specific DNA binding
APA03_RS01525	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APA03_RS01545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APA03_RS01555	COG0598	Magnesium transport protein CorA
APA03_RS01565	COG0133	tryptophan synthase activity
APA03_RS01570	COG0159	tryptophan synthase activity
APA03_RS01575	COG3976	FMN-binding domain protein
APA03_RS01575	COG1053	succinate dehydrogenase
APA03_RS01575	COG0431	NADPH-dependent FMN reductase
APA03_RS01585	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APA03_RS01590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APA03_RS01595	COG0745	RESPONSE REGULATOR receiver
APA03_RS01605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APA03_RS01630	COG1253	flavin adenine dinucleotide binding
APA03_RS01635	COG0604	alcohol dehydrogenase
APA03_RS01645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APA03_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
APA03_RS01665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APA03_RS01670	COG3956	TIGRFAM MazG family protein
APA03_RS01680	COG0326	Molecular chaperone. Has ATPase activity
APA03_RS01770	COG2755	lipolytic protein G-D-S-L family
APA03_RS01770	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APA03_RS01800	COG2079	MmgE PrpD family protein
APA03_RS01805	COG0372	Belongs to the citrate synthase family
APA03_RS01810	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
APA03_RS01815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APA03_RS01820	COG2814	Major facilitator Superfamily
APA03_RS01825	COG2319	Wd-40 repeat
APA03_RS01835	COG2309	aminopeptidase activity
APA03_RS01850	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APA03_RS01860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APA03_RS01865	COG0193	aminoacyl-tRNA hydrolase activity
APA03_RS01870	COG0012	GTP binding
APA03_RS01875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APA03_RS01880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APA03_RS01885	COG0799	negative regulation of ribosome biogenesis
APA03_RS01890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APA03_RS01925	COG0247	lactate metabolic process
APA03_RS01930	COG1139	Iron-sulfur cluster binding protein
APA03_RS01940	COG0697	spore germination
APA03_RS01945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APA03_RS01950	COG0717	Belongs to the dCTP deaminase family
APA03_RS01965	COG3394	polysaccharide catabolic process
APA03_RS01985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APA03_RS01990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APA03_RS01995	COG1253	flavin adenine dinucleotide binding
APA03_RS02000	COG0741	lytic transglycosylase activity
APA03_RS02005	COG1573	uracil-dna glycosylase
APA03_RS02015	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APA03_RS02060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APA03_RS02100	COG1028	Short-chain dehydrogenase reductase Sdr
APA03_RS02110	COG0025	NhaP-type Na H and K H
APA03_RS02120	COG4771	TonB-dependent receptor
APA03_RS02130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APA03_RS02135	COG1120	ATPase activity
APA03_RS02140	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APA03_RS02145	COG2971	BadF BadG BcrA BcrD
APA03_RS02150	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APA03_RS02200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APA03_RS02230	COG3293	Transposase
APA03_RS02245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APA03_RS02320	COG1012	belongs to the aldehyde dehydrogenase family
APA03_RS02475	COG4774	siderophore transport
APA03_RS02585	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APA03_RS02585	COG2755	lipolytic protein G-D-S-L family
APA03_RS02610	COG1054	Belongs to the UPF0176 family
APA03_RS02775	COG1959	2 iron, 2 sulfur cluster binding
APA03_RS02780	COG4221	oxidoreductase activity
APA03_RS02785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APA03_RS02800	COG1607	acyl-coa hydrolase
APA03_RS02830	COG1309	transcriptional regulator
APA03_RS02870	COG1960	acyl-CoA dehydrogenase activity
APA03_RS02875	COG1028	Short-chain dehydrogenase reductase Sdr
APA03_RS02925	COG1012	belongs to the aldehyde dehydrogenase family
APA03_RS02980	COG0306	phosphate transporter
APA03_RS02990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APA03_RS02995	COG0022	dehydrogenase e1 component
APA03_RS03005	COG0071	Belongs to the small heat shock protein (HSP20) family
APA03_RS03020	COG1252	NADH dehydrogenase
APA03_RS03030	COG0523	cobalamin synthesis protein
APA03_RS03040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APA03_RS03050	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
APA03_RS03055	COG0596	Alpha beta hydrolase
APA03_RS03070	COG1297	OPT oligopeptide transporter protein
APA03_RS03100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APA03_RS03110	COG0469	pyruvate kinase activity
APA03_RS03130	COG1217	gtp-binding protein TYPA
APA03_RS03140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APA03_RS03145	COG0492	ferredoxin-NADP+ reductase activity
APA03_RS03150	COG0538	isocitrate dehydrogenase activity
APA03_RS03190	COG4993	Dehydrogenase
APA03_RS03205	COG0481	GTPase activity
APA03_RS03210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APA03_RS03215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APA03_RS03215	COG2813	Specifically methylates the guanine in position
APA03_RS03220	COG0513	Belongs to the DEAD box helicase family
APA03_RS03245	COG1758	RNA polymerase activity
APA03_RS03250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APA03_RS03255	COG0736	holo-[acyl-carrier-protein] synthase activity
APA03_RS03260	COG0681	Belongs to the peptidase S26 family
APA03_RS03265	COG0571	ribonuclease III activity
APA03_RS03275	COG0528	UMP kinase activity
APA03_RS03280	COG0233	cytoplasmic translational termination
APA03_RS03285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APA03_RS03295	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APA03_RS03300	COG0750	zinc metalloprotease
APA03_RS03315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APA03_RS03320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APA03_RS03325	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APA03_RS03330	COG3494	Protein of unknown function (DUF1009)
APA03_RS03335	COG0346	lactoylglutathione lyase activity
APA03_RS03345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APA03_RS03350	COG0594	ribonuclease P activity
APA03_RS03355	COG0706	membrane insertase activity
APA03_RS03360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APA03_RS03365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APA03_RS03370	COG2171	N-acyltransferase activity
APA03_RS03375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APA03_RS03385	COG0101	tRNA pseudouridine synthase activity
APA03_RS03390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APA03_RS03395	COG0242	peptide deformylase activity
APA03_RS03410	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APA03_RS03420	COG0633	Ferredoxin
APA03_RS03420	COG3217	Mosc domain protein beta barrel domain protein
APA03_RS03425	COG1137	ATPase activity
APA03_RS03440	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APA03_RS03440	COG0517	IMP dehydrogenase activity
APA03_RS03450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APA03_RS03465	COG0194	GDP metabolic process
APA03_RS03470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APA03_RS03470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APA03_RS03475	COG2942	2-epimerase
APA03_RS03480	COG0305	Participates in initiation and elongation during chromosome replication
APA03_RS03490	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APA03_RS03490	COG3264	Mechanosensitive ion channel
APA03_RS03495	COG1127	ABC transporter
APA03_RS03500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APA03_RS03535	COG1113	amino acid transport
APA03_RS03545	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APA03_RS03545	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APA03_RS03545	COG0506	proline dehydrogenase activity
APA03_RS03560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APA03_RS03590	COG2096	Adenosyltransferase
APA03_RS03605	COG0277	FAD linked oxidase domain protein
APA03_RS03615	COG0009	L-threonylcarbamoyladenylate synthase
APA03_RS03625	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APA03_RS03635	COG0656	L-ascorbic acid biosynthetic process
APA03_RS03645	COG1643	Atp-dependent helicase
APA03_RS03665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APA03_RS03670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APA03_RS03685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APA03_RS03690	COG0235	Class ii aldolase
APA03_RS03695	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
APA03_RS03700	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
APA03_RS03705	COG0196	riboflavin kinase activity
APA03_RS03710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APA03_RS03715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APA03_RS03725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APA03_RS03735	COG5006	permease, DMT superfamily
APA03_RS03740	COG0187	DNA topoisomerase II activity
APA03_RS03755	COG1959	2 iron, 2 sulfur cluster binding
APA03_RS03760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APA03_RS03765	COG2885	chlorophyll binding
APA03_RS03765	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APA03_RS03775	COG0793	Belongs to the peptidase S41A family
APA03_RS03780	COG0557	exoribonuclease II activity
APA03_RS03785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APA03_RS03790	COG0758	DNA mediated transformation
APA03_RS03810	COG0758	DNA mediated transformation
APA03_RS03815	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APA03_RS03820	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APA03_RS03825	COG0540	Belongs to the ATCase OTCase family
APA03_RS03830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APA03_RS03835	COG0658	competence protein
APA03_RS03835	COG2333	competence protein COMEC
APA03_RS03840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APA03_RS03845	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APA03_RS03855	COG0508	dehydrogenase complex catalyzes the overall conversion of
APA03_RS03875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APA03_RS03925	COG3260	NADH ubiquinone oxidoreductase 20
APA03_RS03930	COG1183	phosphatidylcholine synthase activity
APA03_RS03935	COG0688	phosphatidylethanolamine metabolic process
APA03_RS03940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APA03_RS03950	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APA03_RS03950	COG2885	chlorophyll binding
APA03_RS03955	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APA03_RS03965	COG4974	Belongs to the 'phage' integrase family
APA03_RS03970	COG0825	malonyl-CoA metabolic process
APA03_RS03975	COG1546	Belongs to the CinA family
APA03_RS03975	COG1058	Belongs to the CinA family
APA03_RS03995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APA03_RS04000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APA03_RS04005	COG0181	hydroxymethylbilane synthase activity
APA03_RS04015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APA03_RS04020	COG0406	alpha-ribazole phosphatase activity
APA03_RS04030	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APA03_RS04050	COG0408	coproporphyrinogen oxidase activity
APA03_RS04055	COG2857	Cytochrome c1
APA03_RS04055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APA03_RS04060	COG2857	Cytochrome c1
APA03_RS04060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APA03_RS04065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APA03_RS04085	COG0778	Nitroreductase
APA03_RS04145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APA03_RS04160	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APA03_RS04165	COG0582	viral genome integration into host DNA
APA03_RS04225	COG2963	transposase activity
APA03_RS04235	COG4372	Transposase
APA03_RS04330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APA03_RS04335	COG1902	pentaerythritol trinitrate reductase activity
APA03_RS04340	COG0640	Transcriptional regulator
APA03_RS04350	COG3591	Belongs to the peptidase S1B family
APA03_RS04355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APA03_RS04365	COG0019	diaminopimelate decarboxylase activity
APA03_RS04370	COG0165	Argininosuccinate lyase
APA03_RS04385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APA03_RS04390	COG0237	dephospho-CoA kinase activity
APA03_RS04395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APA03_RS04415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APA03_RS04425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APA03_RS04430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APA03_RS04440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APA03_RS04445	COG0248	Ppx GppA phosphatase
APA03_RS04460	COG1121	(ABC) transporter
APA03_RS04485	COG1289	transmembrane transporter activity
APA03_RS04490	COG1289	transmembrane transporter activity
APA03_RS04510	COG3088	subunit of a heme lyase
APA03_RS04515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APA03_RS04520	COG1138	Cytochrome C-type biogenesis protein
APA03_RS04525	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
APA03_RS04530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APA03_RS04565	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APA03_RS04595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APA03_RS04605	COG0477	Major facilitator Superfamily
APA03_RS04645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APA03_RS04650	COG0081	regulation of translation
APA03_RS04655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APA03_RS04660	COG0222	ribosome binding
APA03_RS04665	COG0085	RNA polymerase activity
APA03_RS04670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APA03_RS04675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APA03_RS04680	COG0049	tRNA binding
APA03_RS04685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APA03_RS04690	COG0051	transcription antitermination factor activity, RNA binding
APA03_RS04695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APA03_RS04700	COG0088	Forms part of the polypeptide exit tunnel
APA03_RS04705	COG0089	rRNA binding
APA03_RS04710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APA03_RS04715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APA03_RS04720	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APA03_RS04725	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APA03_RS04730	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APA03_RS04735	COG0255	Belongs to the universal ribosomal protein uL29 family
APA03_RS04740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APA03_RS04745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APA03_RS04750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APA03_RS04755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APA03_RS04760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APA03_RS04765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APA03_RS04770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APA03_RS04775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APA03_RS04780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APA03_RS04785	COG1841	ribosomal large subunit assembly
APA03_RS04790	COG0200	Binds to the 23S rRNA
APA03_RS04800	COG0563	adenylate kinase activity
APA03_RS04805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APA03_RS04810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APA03_RS04815	COG0202	RNA polymerase activity
APA03_RS04820	COG0203	ribosomal protein L17
APA03_RS04830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APA03_RS04835	COG1116	anion transmembrane transporter activity
APA03_RS04860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APA03_RS04865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APA03_RS04870	COG0477	Major facilitator Superfamily
APA03_RS04875	COG3237	CsbD-like
APA03_RS04880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APA03_RS04885	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APA03_RS04910	COG0714	Associated with various cellular activities
APA03_RS04920	COG0617	tRNA 3'-terminal CCA addition
APA03_RS04925	COG1132	(ABC) transporter
APA03_RS04935	COG2814	Major facilitator Superfamily
APA03_RS04940	COG1051	belongs to the nudix hydrolase family
APA03_RS04950	COG0793	Belongs to the peptidase S41A family
APA03_RS04960	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APA03_RS04965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APA03_RS04970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APA03_RS04975	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APA03_RS04980	COG0505	Belongs to the CarA family
APA03_RS04990	COG0358	DNA primase activity
APA03_RS04995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APA03_RS05005	COG0360	Binds together with S18 to 16S ribosomal RNA
APA03_RS05010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APA03_RS05015	COG0359	binds to the 23S rRNA
APA03_RS05020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APA03_RS05025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APA03_RS05035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APA03_RS05055	COG1132	(ABC) transporter
APA03_RS05060	COG1802	Transcriptional regulator
APA03_RS05065	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APA03_RS05075	COG0850	regulation of cytokinetic process
APA03_RS05085	COG2081	HI0933 family
APA03_RS05090	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APA03_RS05100	COG0457	Tetratricopeptide repeat
APA03_RS05100	COG0859	PFAM glycosyl transferase family 9
APA03_RS05105	COG1329	Transcriptional regulator
APA03_RS05110	COG3781	membrane
APA03_RS05115	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
APA03_RS05130	COG2884	Cell division ATP-binding protein ftsE
APA03_RS05145	COG3852	Histidine kinase
APA03_RS05165	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APA03_RS05170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APA03_RS05190	COG2010	Cytochrome c
APA03_RS05190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APA03_RS05195	COG0246	Mannitol dehydrogenase
APA03_RS05200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APA03_RS05205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APA03_RS05210	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APA03_RS05215	COG0072	phenylalanine-tRNA ligase activity
APA03_RS05215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APA03_RS05225	COG0747	negative chemotaxis
APA03_RS05245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APA03_RS05250	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APA03_RS05260	COG0473	3-isopropylmalate dehydrogenase activity
APA03_RS05265	COG0006	proline dipeptidase activity
APA03_RS05270	COG2264	protein methyltransferase activity
APA03_RS05275	COG0210	DNA helicase
APA03_RS05280	COG2003	Belongs to the UPF0758 family
APA03_RS05285	COG2003	Belongs to the UPF0758 family
APA03_RS05290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APA03_RS05315	COG0071	Belongs to the small heat shock protein (HSP20) family
APA03_RS05320	COG0254	rRNA binding
APA03_RS05325	COG1970	mechanosensitive ion channel activity
APA03_RS05335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APA03_RS05340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APA03_RS05350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APA03_RS05350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APA03_RS05355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APA03_RS05365	COG0142	geranyltranstransferase activity
APA03_RS05370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APA03_RS05375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APA03_RS05390	COG2062	phosphohistidine phosphatase, SixA
APA03_RS05395	COG0287	Prephenate dehydrogenase
APA03_RS05395	COG1605	Chorismate mutase
APA03_RS05420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APA03_RS05430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APA03_RS05440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APA03_RS05450	COG0729	surface antigen
APA03_RS05470	COG0322	excinuclease ABC activity
APA03_RS05485	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APA03_RS05490	COG0314	molybdopterin synthase activity
APA03_RS05495	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APA03_RS05500	COG0156	8-amino-7-oxononanoate synthase activity
APA03_RS05510	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APA03_RS05510	COG4106	trans-aconitate 2-methyltransferase activity
APA03_RS05515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APA03_RS05525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APA03_RS05535	COG0148	phosphopyruvate hydratase activity
APA03_RS05555	COG2022	thiamine diphosphate biosynthetic process
APA03_RS05570	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APA03_RS05575	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APA03_RS05595	COG0076	glutamate decarboxylase activity
APA03_RS05610	COG0484	heat shock protein binding
APA03_RS05615	COG0271	Belongs to the BolA IbaG family
APA03_RS05625	COG0321	lipoyl(octanoyl) transferase activity
APA03_RS05645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APA03_RS05650	COG2226	methyltransferase
APA03_RS05655	COG1040	competence protein
APA03_RS05675	COG2706	6-phosphogluconolactonase activity
APA03_RS05680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APA03_RS05685	COG0527	aspartate kinase activity
APA03_RS05690	COG2070	2-Nitropropane dioxygenase
APA03_RS05700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APA03_RS05705	COG0124	histidyl-tRNA synthetase
APA03_RS05710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APA03_RS05720	COG2890	protein-(glutamine-N5) methyltransferase activity
APA03_RS05740	COG1968	undecaprenyl-diphosphatase activity
APA03_RS05745	COG0531	amino acid
APA03_RS05760	COG2951	lytic endotransglycosylase activity
APA03_RS05765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APA03_RS05770	COG1686	Belongs to the peptidase S11 family
APA03_RS05775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APA03_RS05790	COG0084	hydrolase, TatD family'
APA03_RS05805	COG0259	pyridoxamine-phosphate oxidase activity
APA03_RS05810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APA03_RS05815	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APA03_RS05820	COG1764	response to oxidative stress
APA03_RS05825	COG0579	oxidoreductase
APA03_RS05835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APA03_RS05840	COG0602	queuosine metabolic process
APA03_RS05845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APA03_RS05855	COG0175	sulfate reduction
APA03_RS05860	COG0175	sulfate reduction
APA03_RS05875	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APA03_RS05885	COG1519	Transferase
APA03_RS05890	COG1663	tetraacyldisaccharide 4'-kinase activity
APA03_RS05910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APA03_RS05915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APA03_RS05920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APA03_RS05930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APA03_RS05975	COG1278	Cold shock
APA03_RS05980	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APA03_RS05985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APA03_RS05990	COG1605	Chorismate mutase
APA03_RS05990	COG0077	Prephenate dehydratase
APA03_RS05995	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APA03_RS06000	COG3474	cytochrome
APA03_RS06010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APA03_RS06015	COG0606	chelatase, subunit chli
APA03_RS06020	COG0626	cystathionine gamma-synthase activity
APA03_RS06025	COG2897	thiosulfate sulfurtransferase activity
APA03_RS06030	COG0628	permease
APA03_RS06040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APA03_RS06045	COG0792	nuclease activity
APA03_RS06055	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APA03_RS06060	COG0271	Belongs to the BolA IbaG family
APA03_RS06065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APA03_RS06070	COG0047	phosphoribosylformylglycinamidine synthase activity
APA03_RS06080	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APA03_RS06085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APA03_RS06090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APA03_RS06095	COG0861	Integral membrane protein TerC family
APA03_RS06110	COG1546	Belongs to the CinA family
APA03_RS06125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APA03_RS06130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APA03_RS06135	COG0508	dehydrogenase complex catalyzes the overall conversion of
APA03_RS06140	COG0508	dehydrogenase complex catalyzes the overall conversion of
APA03_RS06140	COG0022	dehydrogenase e1 component
APA03_RS06145	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APA03_RS06150	COG0315	cyclic pyranopterin monophosphate synthase activity
APA03_RS06155	COG0134	indole-3-glycerol-phosphate synthase activity
APA03_RS06160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APA03_RS06170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APA03_RS06180	COG0149	triose-phosphate isomerase activity
APA03_RS06190	COG0504	CTP synthase activity
APA03_RS06195	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APA03_RS06205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APA03_RS06215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APA03_RS06220	COG0268	Binds directly to 16S ribosomal RNA
APA03_RS06225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APA03_RS06230	COG2226	methyltransferase
APA03_RS06235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APA03_RS06240	COG0756	dUTP diphosphatase activity
APA03_RS06245	COG1176	ABC-type spermidine putrescine transport system, permease component I
APA03_RS06250	COG1116	anion transmembrane transporter activity
APA03_RS06255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APA03_RS06260	COG0525	valine-tRNA ligase activity
APA03_RS06275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APA03_RS06300	COG1028	Short-chain dehydrogenase reductase Sdr
APA03_RS06305	COG0456	acetyltransferase
APA03_RS06310	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APA03_RS06315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APA03_RS06320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APA03_RS06330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APA03_RS06335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APA03_RS06345	COG1349	DNA-binding transcription factor activity
APA03_RS06360	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APA03_RS06365	COG4988	ABC transporter
APA03_RS06390	COG0784	Response regulator, receiver
APA03_RS06395	COG0488	(ABC) transporter
APA03_RS06410	COG2824	Alkylphosphonate utilization operon protein PhnA
APA03_RS06415	COG0814	amino acid
APA03_RS06425	COG0384	phenazine biosynthesis protein PhzF
APA03_RS06445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APA03_RS06445	COG1116	anion transmembrane transporter activity
APA03_RS06475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APA03_RS06500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APA03_RS06510	COG2233	PERMEase
APA03_RS06515	COG2351	hydroxyisourate hydrolase activity
APA03_RS06530	COG2072	flavoprotein involved in K transport
APA03_RS06540	COG0402	S-adenosylhomocysteine deaminase activity
APA03_RS06575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APA03_RS06580	COG0842	Transport permease protein
APA03_RS06580	COG1129	ABC transporter
APA03_RS06585	COG0842	Transport permease protein
APA03_RS06600	COG2855	membrane
APA03_RS06610	COG1657	PFAM Prenyltransferase squalene oxidase
APA03_RS06630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APA03_RS06635	COG1012	belongs to the aldehyde dehydrogenase family
APA03_RS06640	COG1902	pentaerythritol trinitrate reductase activity
APA03_RS06645	COG1733	regulation of RNA biosynthetic process
APA03_RS06650	COG0753	catalase activity
APA03_RS06705	COG4178	(ABC) transporter
APA03_RS06760	COG2814	Major facilitator Superfamily
APA03_RS06790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APA03_RS06795	COG0477	Major facilitator Superfamily
APA03_RS06810	COG0848	biopolymer transport protein
APA03_RS06830	COG3293	Transposase
APA03_RS06845	COG4774	siderophore transport
APA03_RS06855	COG4774	siderophore transport
APA03_RS06865	COG1595	DNA-templated transcription, initiation
APA03_RS06870	COG4774	siderophore transport
APA03_RS06890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APA03_RS06895	COG1116	anion transmembrane transporter activity
APA03_RS06900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APA03_RS06910	COG2175	clavaminate synthase activity
APA03_RS06930	COG3293	Transposase
APA03_RS06955	COG2271	Major facilitator Superfamily
APA03_RS06970	COG0583	DNA-binding transcription factor activity
APA03_RS07005	COG1454	alcohol dehydrogenase
APA03_RS07025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APA03_RS07030	COG1116	anion transmembrane transporter activity
APA03_RS07035	COG0864	Transcriptional regulator
APA03_RS07045	COG3665	Urea carboxylase-associated protein
APA03_RS07075	COG4771	TonB-dependent receptor
APA03_RS07085	COG4771	TonB-dependent receptor
APA03_RS07110	COG2211	Major facilitator Superfamily
APA03_RS07130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APA03_RS07145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APA03_RS07200	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APA03_RS07210	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APA03_RS07230	COG3436	PFAM IS66 Orf2 family protein
APA03_RS07235	COG4372	Transposase
APA03_RS07245	COG4372	Transposase
APA03_RS07295	COG1301	dicarboxylic acid transport
APA03_RS07300	COG0500	methyltransferase
APA03_RS07305	COG2999	glutathione oxidoreductase activity
APA03_RS07310	COG2814	Major facilitator Superfamily
APA03_RS07315	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
APA03_RS07365	COG0114	fumarate hydratase activity
APA03_RS07415	COG0628	permease
APA03_RS07440	COG1013	pyruvate-flavodoxin oxidoreductase activity
APA03_RS07440	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APA03_RS07440	COG0674	pyruvate-flavodoxin oxidoreductase activity
APA03_RS07440	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APA03_RS07445	COG0493	'glutamate synthase
APA03_RS07460	COG1971	Probably functions as a manganese efflux pump
APA03_RS07470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APA03_RS07475	COG0746	molybdenum cofactor guanylyltransferase activity
APA03_RS07480	COG1763	Mo-molybdopterin cofactor biosynthetic process
APA03_RS07485	COG0303	'Molybdopterin
APA03_RS07490	COG3058	Necessary for formate dehydrogenase activity
APA03_RS07495	COG2864	formate dehydrogenase
APA03_RS07500	COG0437	4 iron, 4 sulfur cluster binding
APA03_RS07505	COG0243	molybdopterin cofactor binding
APA03_RS07505	COG3383	formate dehydrogenase (NAD+) activity
APA03_RS07515	COG0248	Ppx GppA phosphatase
APA03_RS07520	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APA03_RS07525	COG1940	carbohydrate kinase activity
APA03_RS07530	COG0425	Belongs to the sulfur carrier protein TusA family
APA03_RS07535	COG1722	exodeoxyribonuclease VII activity
APA03_RS07540	COG0142	geranyltranstransferase activity
APA03_RS07545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APA03_RS07550	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
APA03_RS07560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APA03_RS07565	COG0137	argininosuccinate synthase activity
APA03_RS07570	COG0545	Peptidyl-prolyl cis-trans isomerase
APA03_RS07580	COG0180	Tryptophanyl-tRNA synthetase
APA03_RS07595	COG0745	RESPONSE REGULATOR receiver
APA03_RS07610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APA03_RS07610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APA03_RS07625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APA03_RS07640	COG4608	Belongs to the ABC transporter superfamily
APA03_RS07645	COG2070	2-Nitropropane dioxygenase
APA03_RS07650	COG0671	phosphoesterase, PA-phosphatase related
APA03_RS07665	COG3511	phospholipase C
APA03_RS07690	COG0477	Major facilitator Superfamily
APA03_RS07705	COG1695	Transcriptional regulator
APA03_RS07720	COG1289	transmembrane transporter activity
APA03_RS07730	COG1032	radical SAM domain protein
APA03_RS07745	COG0668	transmembrane transport
APA03_RS07765	COG1294	oxidase, subunit
APA03_RS07770	COG1271	oxidase subunit
APA03_RS07775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APA03_RS07780	COG4988	ABC transporter
APA03_RS07790	COG3128	pkhd-type hydroxylase
APA03_RS07795	COG4774	siderophore transport
APA03_RS07815	COG0252	asparaginase activity
APA03_RS07825	COG2985	domain, Protein
APA03_RS07835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APA03_RS07860	COG0488	(ABC) transporter
APA03_RS07865	COG0583	DNA-binding transcription factor activity
APA03_RS07885	COG1064	alcohol dehydrogenase
APA03_RS07900	COG3685	Protein conserved in bacteria
APA03_RS07910	COG1285	pathogenesis
APA03_RS07935	COG0028	Belongs to the TPP enzyme family
APA03_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
APA03_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
APA03_RS07975	COG2814	Major facilitator Superfamily
APA03_RS08030	COG0642	Histidine kinase
APA03_RS08105	COG0318	PFAM AMP-dependent synthetase and ligase
APA03_RS08115	COG0156	8-amino-7-oxononanoate synthase activity
APA03_RS08130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APA03_RS08155	COG0546	phosphoglycolate phosphatase activity
APA03_RS08160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APA03_RS08165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APA03_RS08215	COG0386	Belongs to the glutathione peroxidase family
APA03_RS08220	COG1136	(ABC) transporter
APA03_RS08230	COG0442	prolyl-tRNA aminoacylation
APA03_RS08240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APA03_RS08250	COG1007	ATP synthesis coupled electron transport
APA03_RS08260	COG0713	ATP synthesis coupled electron transport
APA03_RS08270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APA03_RS08275	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APA03_RS08280	COG1034	ATP synthesis coupled electron transport
APA03_RS08290	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APA03_RS08295	COG0649	NAD binding
APA03_RS08300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APA03_RS08305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APA03_RS08330	COG0776	regulation of translation
APA03_RS08340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APA03_RS08345	COG0740	serine-type endopeptidase activity
APA03_RS08350	COG0544	peptidyl-prolyl cis-trans isomerase activity
APA03_RS08360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APA03_RS08360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APA03_RS08375	COG0513	Belongs to the DEAD box helicase family
APA03_RS08385	COG0316	Belongs to the HesB IscA family
APA03_RS08390	COG2151	metal-sulfur cluster biosynthetic enzyme
APA03_RS08400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APA03_RS08405	COG0719	Fe-S assembly protein
APA03_RS08410	COG0396	ATPase activity
APA03_RS08415	COG0719	Fe-S assembly protein
APA03_RS08425	COG2733	membrane
APA03_RS08430	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APA03_RS08440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APA03_RS08445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APA03_RS08455	COG5265	(ABC) transporter
APA03_RS08465	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
APA03_RS08470	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APA03_RS08495	COG0612	Peptidase, M16
APA03_RS08500	COG0312	modulator of DNA gyrase
APA03_RS08515	COG0109	protoheme IX farnesyltransferase activity
APA03_RS08525	COG2226	methyltransferase
APA03_RS08545	COG1522	sequence-specific DNA binding
APA03_RS08550	COG0492	ferredoxin-NADP+ reductase activity
APA03_RS08555	COG0583	DNA-binding transcription factor activity
APA03_RS08560	COG4957	zinc ion binding
APA03_RS08565	COG0776	regulation of translation
APA03_RS08595	COG0776	regulation of translation
APA03_RS08600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APA03_RS08605	COG0416	fatty acid biosynthetic process
APA03_RS08610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APA03_RS08630	COG0745	RESPONSE REGULATOR receiver
APA03_RS08635	COG1846	Transcriptional regulator
APA03_RS08645	COG0242	peptide deformylase activity
APA03_RS08650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APA03_RS08655	COG0473	3-isopropylmalate dehydrogenase activity
APA03_RS08660	COG0066	3-isopropylmalate dehydratase activity
APA03_RS08665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APA03_RS08670	COG0335	large ribosomal subunit rRNA binding
APA03_RS08675	COG0336	Belongs to the RNA methyltransferase TrmD family
APA03_RS08680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APA03_RS08685	COG0228	four-way junction DNA binding
APA03_RS08710	COG0564	pseudouridine synthase activity
APA03_RS08715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APA03_RS08740	COG2814	Major facilitator Superfamily
APA03_RS08745	COG1160	GTP binding
APA03_RS08770	COG0438	transferase activity, transferring glycosyl groups
APA03_RS08775	COG0367	asparagine synthase
APA03_RS08780	COG0354	folic acid binding
APA03_RS08785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APA03_RS08790	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APA03_RS08795	COG0659	secondary active sulfate transmembrane transporter activity
APA03_RS08815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APA03_RS08825	COG1051	belongs to the nudix hydrolase family
APA03_RS08830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APA03_RS08835	COG1923	regulation of RNA biosynthetic process
APA03_RS08840	COG2204	response regulator
APA03_RS08865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APA03_RS08865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APA03_RS08870	COG0463	Glycosyl transferase, family 2
APA03_RS08910	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APA03_RS08920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APA03_RS08935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APA03_RS08945	COG0347	Belongs to the P(II) protein family
APA03_RS08955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APA03_RS08960	COG0586	Pfam SNARE associated Golgi protein
APA03_RS08995	COG3335	DDE superfamily endonuclease
APA03_RS09000	COG3547	Transposase (IS116 IS110 IS902 family)
APA03_RS09010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APA03_RS09015	COG0483	inositol monophosphate 1-phosphatase activity
APA03_RS09020	COG1199	ATP-dependent helicase activity
APA03_RS09025	COG1278	Cold shock
APA03_RS09030	COG0412	Dienelactone hydrolase
APA03_RS09035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APA03_RS09040	COG0459	protein refolding
APA03_RS09050	COG2963	transposase activity
APA03_RS09060	COG4372	Transposase
APA03_RS09160	COG3293	Transposase
APA03_RS09215	COG4372	Transposase
APA03_RS09225	COG2963	transposase activity
APA03_RS09245	COG0004	ammonium transporteR
APA03_RS09265	COG4974	Belongs to the 'phage' integrase family
APA03_RS09275	COG1862	Preprotein translocase
APA03_RS09290	COG0494	nUDIX hydrolase
APA03_RS09310	COG2967	ApaG domain
APA03_RS09315	COG0302	gtp cyclohydrolase
APA03_RS09325	COG0521	Mo-molybdopterin cofactor biosynthetic process
APA03_RS09355	COG1566	PFAM secretion protein HlyD family protein
APA03_RS09385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APA03_RS09390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APA03_RS09390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APA03_RS09395	COG0307	riboflavin synthase, alpha
APA03_RS09405	COG2857	Cytochrome c1
APA03_RS09405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APA03_RS09410	COG2857	Cytochrome c1
APA03_RS09410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APA03_RS09415	COG0723	plastoquinol--plastocyanin reductase activity
APA03_RS09435	COG2252	PERMEase
APA03_RS09540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APA03_RS09545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APA03_RS09550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APA03_RS09555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APA03_RS09565	COG3750	Belongs to the UPF0335 family
APA03_RS09570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APA03_RS09580	COG0657	acetylesterase activity
APA03_RS09590	COG2001	Belongs to the MraZ family
APA03_RS09595	COG0275	rRNA processing
APA03_RS09610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APA03_RS09620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APA03_RS09625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APA03_RS09635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APA03_RS09640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APA03_RS09645	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APA03_RS09650	COG1181	Belongs to the D-alanine--D-alanine ligase family
APA03_RS09655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APA03_RS09660	COG0849	cell division
APA03_RS09670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APA03_RS09675	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APA03_RS09680	COG0497	DNA recombination
APA03_RS09685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APA03_RS09690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APA03_RS09690	COG0574	Belongs to the PEP-utilizing enzyme family
APA03_RS09695	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APA03_RS09720	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APA03_RS09735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APA03_RS09740	COG1335	isochorismatase
APA03_RS09760	COG2132	Multicopper oxidase
APA03_RS09770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APA03_RS09780	COG0028	Belongs to the TPP enzyme family
APA03_RS09785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APA03_RS09790	COG3830	Belongs to the UPF0237 family
APA03_RS09790	COG0560	Phosphoserine phosphatase
APA03_RS09805	COG0513	Belongs to the DEAD box helicase family
APA03_RS09825	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APA03_RS09830	COG0531	amino acid
APA03_RS09835	COG0113	porphobilinogen synthase activity
APA03_RS09840	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
APA03_RS09845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APA03_RS09850	COG1381	Involved in DNA repair and RecF pathway recombination
APA03_RS09855	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APA03_RS09860	COG0052	Belongs to the universal ribosomal protein uS2 family
APA03_RS09885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APA03_RS09895	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APA03_RS09900	COG0251	oxidation-reduction process
APA03_RS09915	COG0436	Aminotransferase
APA03_RS09920	COG0436	Aminotransferase
APA03_RS09925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APA03_RS09945	COG3161	chorismate lyase activity
APA03_RS09950	COG1032	radical SAM domain protein
APA03_RS09955	COG0105	UTP biosynthetic process
APA03_RS09960	COG0488	(ABC) transporter
APA03_RS09970	COG0745	RESPONSE REGULATOR receiver
APA03_RS09975	COG0642	Histidine kinase
APA03_RS09975	COG3850	Histidine kinase
APA03_RS09985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APA03_RS09990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APA03_RS10010	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APA03_RS10025	COG0328	RNA-DNA hybrid ribonuclease activity
APA03_RS10030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APA03_RS10035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APA03_RS10085	COG1530	ribonuclease E activity
APA03_RS10090	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APA03_RS10095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APA03_RS10100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APA03_RS10105	COG0424	maF-like protein
APA03_RS10115	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
APA03_RS10390	COG0277	FAD linked oxidase domain protein
APA03_RS10405	COG2308	Evidence 4 Homologs of previously reported genes of
APA03_RS10430	COG1309	transcriptional regulator
APA03_RS10435	COG1252	NADH dehydrogenase
APA03_RS10440	COG1012	belongs to the aldehyde dehydrogenase family
APA03_RS10445	COG2814	Major facilitator Superfamily
APA03_RS10455	COG0431	NADPH-dependent FMN reductase
APA03_RS10465	COG0583	DNA-binding transcription factor activity
APA03_RS10500	COG0697	spore germination
APA03_RS10505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APA03_RS10510	COG1984	allophanate hydrolase subunit 2
APA03_RS10520	COG4221	oxidoreductase activity
APA03_RS10525	COG0511	ligase activity, forming carbon-carbon bonds
APA03_RS10540	COG0436	Aminotransferase
APA03_RS10555	COG0300	oxidoreductase activity
APA03_RS10565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APA03_RS10570	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APA03_RS10575	COG0297	glycogen (starch) synthase activity
APA03_RS10590	COG1028	Short-chain dehydrogenase reductase Sdr
APA03_RS10595	COG0028	Belongs to the TPP enzyme family
APA03_RS10610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APA03_RS10615	COG1999	signal sequence binding
APA03_RS10680	COG0583	DNA-binding transcription factor activity
APA03_RS10685	COG1289	transmembrane transporter activity
APA03_RS10720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APA03_RS10725	COG0805	protein transport
APA03_RS10730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APA03_RS10735	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APA03_RS10740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APA03_RS10750	COG0018	arginyl-trna synthetase
APA03_RS10755	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APA03_RS10760	COG0316	Belongs to the HesB IscA family
APA03_RS10765	COG0708	Exodeoxyribonuclease III
APA03_RS10785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APA03_RS10790	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
APA03_RS10800	COG0535	radical SAM domain protein
APA03_RS10810	COG0740	serine-type endopeptidase activity
APA03_RS10820	COG0436	Aminotransferase
APA03_RS10830	COG1494	fructose-1,6-bisphosphatase
APA03_RS10845	COG0564	pseudouridine synthase activity
APA03_RS10850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APA03_RS10855	COG1120	ATPase activity
APA03_RS10860	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APA03_RS10870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APA03_RS10875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APA03_RS10875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APA03_RS10905	COG1294	oxidase, subunit
APA03_RS10910	COG1271	oxidase subunit
APA03_RS10925	COG1113	amino acid transport
APA03_RS10935	COG4993	Dehydrogenase
APA03_RS10945	COG1942	4-Oxalocrotonate Tautomerase
APA03_RS10950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APA03_RS10955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APA03_RS10970	COG0493	'glutamate synthase
APA03_RS10975	COG4372	Transposase
APA03_RS10985	COG2963	transposase activity
APA03_RS11005	COG1953	Uracil, thiamine, allantoin
APA03_RS11020	COG0135	phosphoribosylanthranilate isomerase activity
APA03_RS11025	COG0284	orotidine-5'-phosphate decarboxylase activity
APA03_RS11035	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APA03_RS11045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APA03_RS11050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APA03_RS11060	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APA03_RS11085	COG3145	DNA-N1-methyladenine dioxygenase activity
APA03_RS11095	COG3620	sequence-specific DNA binding
APA03_RS11105	COG2011	ABC-type metal ion transport system permease component
APA03_RS11110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APA03_RS11120	COG0277	FAD linked oxidase domain protein
APA03_RS11125	COG1648	precorrin-2 dehydrogenase activity
APA03_RS11125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APA03_RS11140	COG1846	Transcriptional regulator
APA03_RS11145	COG0154	amidase activity
APA03_RS11150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APA03_RS11155	COG0235	Class ii aldolase
APA03_RS11180	COG4638	Rieske (2fe-2S)
APA03_RS11200	COG1012	belongs to the aldehyde dehydrogenase family
APA03_RS11225	COG1177	transmembrane transport
APA03_RS11230	COG1176	ABC-type spermidine putrescine transport system, permease component I
APA03_RS11240	COG3293	Transposase
APA03_RS11245	COG1176	ABC-type spermidine putrescine transport system, permease component I
APA03_RS11250	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APA03_RS11255	COG3842	ATPase activity
APA03_RS11260	COG1012	belongs to the aldehyde dehydrogenase family
APA03_RS11280	COG3128	pkhd-type hydroxylase
APA03_RS11295	COG4774	siderophore transport
APA03_RS11305	COG0848	biopolymer transport protein
APA03_RS11325	COG1301	dicarboxylic acid transport
APA03_RS11360	COG2814	Major facilitator Superfamily
APA03_RS11370	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
APA03_RS11375	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
APA03_RS11390	COG0778	Nitroreductase
APA03_RS11395	COG1492	cobalamin metabolic process
APA03_RS11410	COG1797	cobyrinic acid a,c-diamide synthase activity
APA03_RS11440	COG1289	transmembrane transporter activity
APA03_RS11445	COG1584	GPR1 FUN34 yaaH family protein
APA03_RS11450	COG1024	Enoyl-CoA hydratase
APA03_RS11455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APA03_RS11460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APA03_RS11475	COG0735	belongs to the Fur family
APA03_RS11490	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APA03_RS11510	COG0519	Catalyzes the synthesis of GMP from XMP
APA03_RS11510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APA03_RS11565	COG3293	Transposase
APA03_RS11630	COG2814	Major facilitator Superfamily
APA03_RS11635	COG0739	heme binding
APA03_RS11635	COG1196	nuclear chromosome segregation
APA03_RS11635	COG0741	lytic transglycosylase activity
APA03_RS11655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APA03_RS11665	COG1496	oxidoreductase activity
APA03_RS11695	COG1742	UPF0060 membrane protein
APA03_RS11710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APA03_RS11725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APA03_RS11730	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APA03_RS11740	COG0363	glucosamine-6-phosphate deaminase activity
APA03_RS11745	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APA03_RS11750	COG3265	gluconokinase activity
APA03_RS11775	COG1063	alcohol dehydrogenase
APA03_RS11785	COG3158	transport of potassium into the cell
APA03_RS11790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APA03_RS11815	COG0411	ABC transporter
APA03_RS11835	COG2198	Histidine kinase
APA03_RS11835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APA03_RS11835	COG0784	Response regulator, receiver
APA03_RS11835	COG2205	protein histidine kinase activity
APA03_RS11840	COG0745	RESPONSE REGULATOR receiver
APA03_RS11880	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APA03_RS11885	COG0830	nickel cation binding
APA03_RS11890	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
APA03_RS11895	COG0804	urea catabolic process
APA03_RS11900	COG0832	Belongs to the urease beta subunit family
APA03_RS11905	COG0831	urea catabolic process
APA03_RS11910	COG0829	nickel cation binding
APA03_RS11915	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
APA03_RS11920	COG3961	Belongs to the TPP enzyme family
APA03_RS11945	COG1393	Belongs to the ArsC family
APA03_RS11955	COG2818	Glycosylase
APA03_RS11965	COG0450	alkyl hydroperoxide reductase
APA03_RS12015	COG0583	DNA-binding transcription factor activity
APA03_RS12030	COG2271	Major facilitator Superfamily
APA03_RS12040	COG3473	Maleate cis-trans isomerase
APA03_RS12045	COG0596	Alpha beta hydrolase
APA03_RS12050	COG1335	isochorismatase
APA03_RS12055	COG2309	aminopeptidase activity
APA03_RS12060	COG2010	Cytochrome c
APA03_RS12060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APA03_RS12065	COG2080	2 iron, 2 sulfur cluster binding
APA03_RS12070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APA03_RS12075	COG1846	Transcriptional regulator
APA03_RS12095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APA03_RS12265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APA03_RS12275	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APA03_RS12295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APA03_RS12295	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APA03_RS12300	COG0509	glycine decarboxylation via glycine cleavage system
APA03_RS12305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APA03_RS12310	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APA03_RS12315	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APA03_RS12340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APA03_RS12345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APA03_RS12360	COG1185	polyribonucleotide nucleotidyltransferase activity
APA03_RS12365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APA03_RS12370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APA03_RS12375	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APA03_RS12380	COG1127	ABC transporter
APA03_RS12385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APA03_RS12385	COG3008	intermembrane lipid transfer
APA03_RS12430	COG1410	methionine synthase
APA03_RS12430	COG0646	methionine synthase
APA03_RS12445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APA03_RS12455	COG3008	intermembrane lipid transfer
APA03_RS12460	COG2995	paraquat-inducible protein a
APA03_RS12470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APA03_RS12475	COG0463	Glycosyl transferase, family 2
APA03_RS12480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APA03_RS12485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APA03_RS12490	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APA03_RS12495	COG0356	it plays a direct role in the translocation of protons across the membrane
APA03_RS12505	COG0552	protein localization to endoplasmic reticulum
APA03_RS12510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APA03_RS12515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APA03_RS12520	COG0346	lactoylglutathione lyase activity
APA03_RS12530	COG0513	Belongs to the DEAD box helicase family
APA03_RS12550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APA03_RS12565	COG0704	Plays a role in the regulation of phosphate uptake
APA03_RS12570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APA03_RS12580	COG0573	inorganic phosphate transmembrane transporter activity
APA03_RS12585	COG0129	dihydroxy-acid dehydratase activity
APA03_RS12620	COG0489	protein tyrosine kinase activity
APA03_RS12635	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
APA03_RS12645	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APA03_RS12645	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APA03_RS12660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APA03_RS12665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APA03_RS12670	COG1522	sequence-specific DNA binding
APA03_RS12675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APA03_RS12680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APA03_RS12695	COG0779	Required for maturation of 30S ribosomal subunits
APA03_RS12705	COG0542	response to heat
APA03_RS12720	COG0765	amino acid transport
APA03_RS12725	COG1126	abc transporter atp-binding protein
APA03_RS12735	COG4133	protoheme IX ABC transporter activity
APA03_RS12755	COG1295	ribonuclease BN
APA03_RS12765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APA03_RS12770	COG0511	ligase activity, forming carbon-carbon bonds
APA03_RS12775	COG0439	Biotin carboxylase
APA03_RS12780	COG2814	Major facilitator Superfamily
APA03_RS12785	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APA03_RS12835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APA03_RS12845	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APA03_RS12850	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APA03_RS12855	COG0154	amidase activity
APA03_RS12860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APA03_RS12870	COG5265	(ABC) transporter
APA03_RS12875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APA03_RS12880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APA03_RS12885	COG1194	a g-specific adenine glycosylase
APA03_RS12910	COG0495	leucyl-tRNA aminoacylation
APA03_RS12985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APA03_RS12995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APA03_RS13000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APA03_RS13005	COG0590	tRNA wobble adenosine to inosine editing
APA03_RS13010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APA03_RS13015	COG1187	pseudouridine synthase activity
APA03_RS13020	COG0742	ribosomal rna small subunit methyltransferase
APA03_RS13025	COG0629	single-stranded DNA binding
APA03_RS13080	COG3293	Transposase
APA03_RS13085	COG0438	transferase activity, transferring glycosyl groups
APA03_RS13095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APA03_RS13100	COG0312	modulator of DNA gyrase
APA03_RS13105	COG0406	alpha-ribazole phosphatase activity
APA03_RS13125	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
APA03_RS13130	COG1091	dTDP-4-dehydrorhamnose reductase activity
APA03_RS13140	COG1674	ftsk spoiiie
APA03_RS13145	COG0564	pseudouridine synthase activity
APA03_RS13160	COG0482	sulfurtransferase activity
APA03_RS13170	COG1104	cysteine desulfurase activity
APA03_RS13175	COG1104	cysteine desulfurase activity
APA03_RS13180	COG2945	thiolester hydrolase activity
APA03_RS13190	COG0215	cysteine-tRNA ligase activity
APA03_RS13200	COG0285	dihydrofolate synthase activity
APA03_RS13205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APA03_RS13220	COG2887	Belongs to the helicase family. UvrD subfamily
APA03_RS13225	COG0802	atpase or kinase
APA03_RS13235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APA03_RS13245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APA03_RS13250	COG0037	tRNA processing
APA03_RS13260	COG2885	chlorophyll binding
APA03_RS13265	COG0823	Involved in the tonB-independent uptake of proteins
APA03_RS13275	COG0848	biopolymer transport protein
APA03_RS13285	COG0824	Thioesterase
APA03_RS13290	COG2255	four-way junction helicase activity
APA03_RS13295	COG0632	four-way junction helicase activity
APA03_RS13300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APA03_RS13305	COG0217	transcriptional regulatory protein
APA03_RS13310	COG0653	protein targeting
APA03_RS13315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APA03_RS13320	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APA03_RS13330	COG0668	transmembrane transport
APA03_RS13345	COG0484	heat shock protein binding
APA03_RS13380	COG0776	regulation of translation
APA03_RS13400	COG1216	Glycosyl transferase, family 2
APA03_RS13415	COG0131	Imidazoleglycerol-phosphate dehydratase
APA03_RS13420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APA03_RS13425	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APA03_RS13430	COG0107	imidazoleglycerol-phosphate synthase activity
APA03_RS13435	COG0140	phosphoribosyl-ATP diphosphatase activity
APA03_RS13445	COG0778	Nitroreductase
APA03_RS13485	COG0357	Ribosomal RNA small subunit methyltransferase G
APA03_RS13490	COG0445	tRNA wobble uridine modification
APA03_RS13495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APA03_RS13500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APA03_RS13530	COG1611	Belongs to the LOG family
APA03_RS13545	COG1981	membrane
APA03_RS13550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APA03_RS13555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APA03_RS13560	COG0424	maF-like protein
APA03_RS13640	COG0210	DNA helicase
APA03_RS13650	COG3547	Transposase (IS116 IS110 IS902 family)
APA03_RS13655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APA03_RS13665	COG0246	Mannitol dehydrogenase
APA03_RS13775	COG1192	Involved in chromosome partitioning
APA03_RS13780	COG1475	DNA binding
APA03_RS13795	COG0776	regulation of translation
APA03_RS13835	COG1309	transcriptional regulator
APA03_RS13840	COG1979	alcohol dehydrogenase
APA03_RS13845	COG1012	belongs to the aldehyde dehydrogenase family
APA03_RS13875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APA03_RS13880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APA03_RS13885	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
APA03_RS13890	COG2205	protein histidine kinase activity
APA03_RS13895	COG0745	RESPONSE REGULATOR receiver
APA03_RS13920	COG3551	Protein conserved in bacteria
APA03_RS13945	COG0640	Transcriptional regulator
APA03_RS13960	COG0584	glycerophosphoryl diester phosphodiesterase
APA03_RS13975	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APA03_RS14045	COG1914	H( )-stimulated, divalent metal cation uptake system
APA03_RS14050	COG1321	iron dependent repressor
APA03_RS14140	COG1203	CRISPR-associated helicase, Cas3
APA03_RS14155	COG1857	crispr-associated protein
APA03_RS14170	COG1518	maintenance of DNA repeat elements
APA03_RS14175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APA03_RS14255	COG3077	Addiction module antitoxin, RelB DinJ family
APA03_RS14260	COG2026	Addiction module toxin, RelE StbE family
APA03_RS14270	COG4716	Myosin-crossreactive antigen
APA03_RS14380	COG2337	Toxic component of a toxin-antitoxin (TA) module
APA03_RS14385	COG2336	PFAM SpoVT AbrB
APA03_RS14425	COG1028	Short-chain dehydrogenase reductase Sdr
APA03_RS14435	COG2072	flavoprotein involved in K transport
APA03_RS14450	COG2144	transferase activity, transferring acyl groups
APA03_RS14475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APA03_RS14485	COG0583	DNA-binding transcription factor activity
APA03_RS14510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APA03_RS14555	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APA03_RS14570	COG0732	type I restriction modification DNA specificity domain
APA03_RS14575	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
APA03_RS14585	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APA03_RS14590	COG1902	pentaerythritol trinitrate reductase activity
APA03_RS14630	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
APA03_RS14640	COG1012	belongs to the aldehyde dehydrogenase family
APA03_RS14645	COG2072	flavoprotein involved in K transport
APA03_RS14665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APA03_RS14665	COG1116	anion transmembrane transporter activity
APA03_RS14675	COG0243	molybdopterin cofactor binding
APA03_RS14685	COG0243	molybdopterin cofactor binding
APA03_RS14690	COG2146	nitrite reductase [NAD(P)H] activity
APA03_RS14690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APA03_RS14695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APA03_RS14695	COG2146	nitrite reductase [NAD(P)H] activity
APA03_RS14715	COG0642	Histidine kinase
APA03_RS14770	COG0583	DNA-binding transcription factor activity
APA03_RS14775	COG3293	Transposase
APA03_RS14790	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
APA03_RS14795	COG2072	flavoprotein involved in K transport
APA03_RS14800	COG0431	NADPH-dependent FMN reductase
APA03_RS14805	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APA03_RS14825	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APA03_RS14865	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APA03_RS14885	COG0583	DNA-binding transcription factor activity
APA03_RS14920	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APA03_RS14940	COG3158	transport of potassium into the cell
APA03_RS14955	COG3158	transport of potassium into the cell
APA03_RS15065	COG4221	oxidoreductase activity
APA03_RS15135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APA03_RS15165	COG0789	Transcriptional regulator
APA03_RS15180	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APA03_RS15185	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APA03_RS15190	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
APA03_RS15195	COG2205	protein histidine kinase activity
APA03_RS15200	COG0745	RESPONSE REGULATOR receiver
APA03_RS15210	COG1028	Short-chain dehydrogenase reductase Sdr
APA03_RS15235	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APA03_RS15315	COG3415	Transposase
APA03_RS15315	COG2801	Transposase and inactivated derivatives
APA03_RS15350	COG3293	Transposase
APA03_RS15360	COG4974	Belongs to the 'phage' integrase family
APA03_RS15415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APA03_RS15560	COG4691	Plasmid stability protein
APA03_RS15565	COG1487	ribonuclease activity
APA03_RS15595	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
APA03_RS15605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APA03_RS15620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APA03_RS15625	COG1061	Type III restriction enzyme res subunit
APA03_RS15630	COG1002	Type II restriction enzyme, methylase subunits
APA03_RS15690	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system