locus-tag	class	description
APA22_RS00015	COG0582	viral genome integration into host DNA
APA22_RS00020	COG1671	Belongs to the UPF0178 family
APA22_RS00030	COG2814	Major facilitator Superfamily
APA22_RS00040	COG2835	tetraacyldisaccharide 4'-kinase activity
APA22_RS00045	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APA22_RS00055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APA22_RS00080	COG0778	Nitroreductase
APA22_RS00090	COG0456	acetyltransferase
APA22_RS00115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APA22_RS00120	COG1012	belongs to the aldehyde dehydrogenase family
APA22_RS00130	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APA22_RS00145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APA22_RS00155	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APA22_RS00165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APA22_RS00180	COG0126	phosphoglycerate kinase activity
APA22_RS00190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APA22_RS00200	COG0156	8-amino-7-oxononanoate synthase activity
APA22_RS00205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APA22_RS00210	COG0405	Gamma-glutamyltransferase
APA22_RS00230	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
APA22_RS00240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APA22_RS00255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APA22_RS00260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APA22_RS00265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APA22_RS00275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APA22_RS00285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APA22_RS00290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APA22_RS00295	COG0539	negative regulation of cytoplasmic translation
APA22_RS00310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APA22_RS00315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APA22_RS00320	COG1420	regulation of RNA biosynthetic process
APA22_RS00325	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APA22_RS00360	COG0772	Belongs to the SEDS family
APA22_RS00365	COG0768	penicillin binding
APA22_RS00385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APA22_RS00390	COG1612	heme a metabolic process
APA22_RS00400	COG2814	Major facilitator Superfamily
APA22_RS00410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APA22_RS00415	COG1289	transmembrane transporter activity
APA22_RS00425	COG1573	uracil-dna glycosylase
APA22_RS00445	COG0670	Belongs to the BI1 family
APA22_RS00470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APA22_RS00490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APA22_RS00505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APA22_RS00525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APA22_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
APA22_RS00550	COG0586	Pfam SNARE associated Golgi protein
APA22_RS00560	COG0281	malic enzyme
APA22_RS00590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APA22_RS00595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APA22_RS00600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APA22_RS00605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APA22_RS00610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APA22_RS00615	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APA22_RS00620	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APA22_RS00625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APA22_RS00640	COG1113	amino acid transport
APA22_RS00645	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APA22_RS00650	COG4208	sulfate ABC transporter
APA22_RS00680	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APA22_RS00685	COG2207	Transcriptional regulator
APA22_RS00690	COG4303	Ethanolamine ammonia lyase large subunit
APA22_RS00695	COG4302	ethanolamine ammonia-lyase activity
APA22_RS00705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APA22_RS00720	COG1278	Cold shock
APA22_RS00775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APA22_RS00785	COG2205	protein histidine kinase activity
APA22_RS00785	COG0784	Response regulator, receiver
APA22_RS00810	COG1137	ATPase activity
APA22_RS00875	COG0515	serine threonine protein kinase
APA22_RS00875	COG2815	serine threonine protein kinase
APA22_RS00890	COG4372	Transposase
APA22_RS00900	COG2963	transposase activity
APA22_RS00920	COG2983	Belongs to the UPF0260 family
APA22_RS00935	COG3842	ATPase activity
APA22_RS00960	COG1566	PFAM secretion protein HlyD family protein
APA22_RS00980	COG1657	PFAM Prenyltransferase squalene oxidase
APA22_RS00985	COG1233	COG1233 Phytoene dehydrogenase and related
APA22_RS00990	COG1562	ergosterol biosynthetic process
APA22_RS00995	COG1562	ergosterol biosynthetic process
APA22_RS01005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APA22_RS01015	COG0287	Prephenate dehydrogenase
APA22_RS01035	COG0450	alkyl hydroperoxide reductase
APA22_RS01040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APA22_RS01055	COG3384	dioxygenase
APA22_RS01060	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APA22_RS01070	COG0488	(ABC) transporter
APA22_RS01090	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APA22_RS01100	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APA22_RS01105	COG0343	queuine tRNA-ribosyltransferase activity
APA22_RS01110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APA22_RS01120	COG1881	PFAM PEBP family protein
APA22_RS01135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APA22_RS01150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APA22_RS01180	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
APA22_RS01185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APA22_RS01200	COG0667	Aldo Keto reductase
APA22_RS01210	COG0556	nucleotide-excision repair
APA22_RS01220	COG0612	Peptidase, M16
APA22_RS01255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APA22_RS01270	COG0167	dihydroorotate dehydrogenase activity
APA22_RS01285	COG1692	metallophosphoesterase
APA22_RS01290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APA22_RS01315	COG0352	thiamine-phosphate diphosphorylase activity
APA22_RS01390	COG1509	lysine 2,3-aminomutase activity
APA22_RS01400	COG0024	Methionine aminopeptidase
APA22_RS01405	COG1686	Belongs to the peptidase S11 family
APA22_RS01410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APA22_RS01425	COG2326	polyphosphate kinase activity
APA22_RS01430	COG1678	Uncharacterized ACR, COG1678
APA22_RS01435	COG1660	Displays ATPase and GTPase activities
APA22_RS01445	COG2205	protein histidine kinase activity
APA22_RS01450	COG0745	RESPONSE REGULATOR receiver
APA22_RS01455	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APA22_RS01460	COG0443	Heat shock 70 kDa protein
APA22_RS01465	COG0484	heat shock protein binding
APA22_RS01470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APA22_RS01475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APA22_RS01480	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APA22_RS01485	COG0138	bifunctional purine biosynthesis protein purh
APA22_RS01500	COG0697	spore germination
APA22_RS01515	COG0752	glycyl-tRNA synthetase alpha subunit
APA22_RS01525	COG1396	sequence-specific DNA binding
APA22_RS01530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APA22_RS01550	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APA22_RS01560	COG0598	Magnesium transport protein CorA
APA22_RS01570	COG0133	tryptophan synthase activity
APA22_RS01575	COG0159	tryptophan synthase activity
APA22_RS01580	COG0431	NADPH-dependent FMN reductase
APA22_RS01580	COG1053	succinate dehydrogenase
APA22_RS01580	COG3976	FMN-binding domain protein
APA22_RS01590	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APA22_RS01595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APA22_RS01600	COG0745	RESPONSE REGULATOR receiver
APA22_RS01610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APA22_RS01635	COG1253	flavin adenine dinucleotide binding
APA22_RS01640	COG0604	alcohol dehydrogenase
APA22_RS01650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APA22_RS01665	COG1028	Short-chain dehydrogenase reductase Sdr
APA22_RS01670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APA22_RS01675	COG3956	TIGRFAM MazG family protein
APA22_RS01685	COG0326	Molecular chaperone. Has ATPase activity
APA22_RS01775	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APA22_RS01775	COG2755	lipolytic protein G-D-S-L family
APA22_RS01805	COG2079	MmgE PrpD family protein
APA22_RS01810	COG0372	Belongs to the citrate synthase family
APA22_RS01815	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
APA22_RS01820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APA22_RS01825	COG2814	Major facilitator Superfamily
APA22_RS01830	COG2319	Wd-40 repeat
APA22_RS01840	COG2309	aminopeptidase activity
APA22_RS01855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APA22_RS01865	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APA22_RS01870	COG0193	aminoacyl-tRNA hydrolase activity
APA22_RS01875	COG0012	GTP binding
APA22_RS01880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APA22_RS01885	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APA22_RS01890	COG0799	negative regulation of ribosome biogenesis
APA22_RS01895	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APA22_RS01930	COG0247	lactate metabolic process
APA22_RS01935	COG1139	Iron-sulfur cluster binding protein
APA22_RS01945	COG0697	spore germination
APA22_RS01950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APA22_RS01955	COG0717	Belongs to the dCTP deaminase family
APA22_RS01970	COG3394	polysaccharide catabolic process
APA22_RS01990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APA22_RS02000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APA22_RS02005	COG1253	flavin adenine dinucleotide binding
APA22_RS02010	COG0741	lytic transglycosylase activity
APA22_RS02015	COG1573	uracil-dna glycosylase
APA22_RS02025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APA22_RS02070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APA22_RS02110	COG1028	Short-chain dehydrogenase reductase Sdr
APA22_RS02120	COG0025	NhaP-type Na H and K H
APA22_RS02130	COG4771	TonB-dependent receptor
APA22_RS02140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APA22_RS02145	COG1120	ATPase activity
APA22_RS02150	COG3525	Glycosyl hydrolase, family 20, catalytic domain
APA22_RS02155	COG2971	BadF BadG BcrA BcrD
APA22_RS02160	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APA22_RS02210	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APA22_RS02240	COG3293	Transposase
APA22_RS02255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APA22_RS02330	COG1012	belongs to the aldehyde dehydrogenase family
APA22_RS02485	COG4774	siderophore transport
APA22_RS02595	COG2755	lipolytic protein G-D-S-L family
APA22_RS02595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APA22_RS02620	COG1054	Belongs to the UPF0176 family
APA22_RS02785	COG1959	2 iron, 2 sulfur cluster binding
APA22_RS02790	COG4221	oxidoreductase activity
APA22_RS02795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APA22_RS02810	COG1607	acyl-coa hydrolase
APA22_RS02840	COG1309	transcriptional regulator
APA22_RS02880	COG1960	acyl-CoA dehydrogenase activity
APA22_RS02885	COG1028	Short-chain dehydrogenase reductase Sdr
APA22_RS02935	COG1012	belongs to the aldehyde dehydrogenase family
APA22_RS02990	COG0306	phosphate transporter
APA22_RS03000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APA22_RS03005	COG0022	dehydrogenase e1 component
APA22_RS03015	COG0071	Belongs to the small heat shock protein (HSP20) family
APA22_RS03030	COG1252	NADH dehydrogenase
APA22_RS03040	COG0523	cobalamin synthesis protein
APA22_RS03050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APA22_RS03060	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
APA22_RS03065	COG0596	Alpha beta hydrolase
APA22_RS03080	COG1297	OPT oligopeptide transporter protein
APA22_RS03110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APA22_RS03120	COG0469	pyruvate kinase activity
APA22_RS03140	COG1217	gtp-binding protein TYPA
APA22_RS03150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APA22_RS03155	COG0492	ferredoxin-NADP+ reductase activity
APA22_RS03160	COG0538	isocitrate dehydrogenase activity
APA22_RS03200	COG4993	Dehydrogenase
APA22_RS03215	COG0481	GTPase activity
APA22_RS03220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APA22_RS03225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APA22_RS03225	COG2813	Specifically methylates the guanine in position
APA22_RS03230	COG0513	Belongs to the DEAD box helicase family
APA22_RS03255	COG1758	RNA polymerase activity
APA22_RS03260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APA22_RS03265	COG0736	holo-[acyl-carrier-protein] synthase activity
APA22_RS03270	COG0681	Belongs to the peptidase S26 family
APA22_RS03275	COG0571	ribonuclease III activity
APA22_RS03285	COG0528	UMP kinase activity
APA22_RS03290	COG0233	cytoplasmic translational termination
APA22_RS03295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APA22_RS03305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APA22_RS03310	COG0750	zinc metalloprotease
APA22_RS03325	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APA22_RS03330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APA22_RS03335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APA22_RS03340	COG3494	Protein of unknown function (DUF1009)
APA22_RS03345	COG0346	lactoylglutathione lyase activity
APA22_RS03355	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APA22_RS03360	COG0594	ribonuclease P activity
APA22_RS03365	COG0706	membrane insertase activity
APA22_RS03370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APA22_RS03375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APA22_RS03380	COG2171	N-acyltransferase activity
APA22_RS03385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APA22_RS03395	COG0101	tRNA pseudouridine synthase activity
APA22_RS03400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APA22_RS03405	COG0242	peptide deformylase activity
APA22_RS03420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APA22_RS03430	COG0633	Ferredoxin
APA22_RS03430	COG3217	Mosc domain protein beta barrel domain protein
APA22_RS03435	COG1137	ATPase activity
APA22_RS03450	COG0517	IMP dehydrogenase activity
APA22_RS03450	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APA22_RS03460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APA22_RS03475	COG0194	GDP metabolic process
APA22_RS03480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APA22_RS03480	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APA22_RS03485	COG2942	2-epimerase
APA22_RS03490	COG0305	Participates in initiation and elongation during chromosome replication
APA22_RS03500	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APA22_RS03500	COG3264	Mechanosensitive ion channel
APA22_RS03505	COG1127	ABC transporter
APA22_RS03510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APA22_RS03545	COG1113	amino acid transport
APA22_RS03555	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APA22_RS03555	COG0506	proline dehydrogenase activity
APA22_RS03555	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APA22_RS03570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APA22_RS03600	COG2096	Adenosyltransferase
APA22_RS03615	COG0277	FAD linked oxidase domain protein
APA22_RS03625	COG0009	L-threonylcarbamoyladenylate synthase
APA22_RS03635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APA22_RS03645	COG0656	L-ascorbic acid biosynthetic process
APA22_RS03655	COG1643	Atp-dependent helicase
APA22_RS03675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APA22_RS03680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APA22_RS03695	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APA22_RS03700	COG0235	Class ii aldolase
APA22_RS03705	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
APA22_RS03710	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
APA22_RS03715	COG0196	riboflavin kinase activity
APA22_RS03720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APA22_RS03725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APA22_RS03735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APA22_RS03745	COG5006	permease, DMT superfamily
APA22_RS03750	COG0187	DNA topoisomerase II activity
APA22_RS03765	COG1959	2 iron, 2 sulfur cluster binding
APA22_RS03770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APA22_RS03775	COG2885	chlorophyll binding
APA22_RS03775	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APA22_RS03785	COG0793	Belongs to the peptidase S41A family
APA22_RS03790	COG0557	exoribonuclease II activity
APA22_RS03795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APA22_RS03800	COG0758	DNA mediated transformation
APA22_RS03820	COG0758	DNA mediated transformation
APA22_RS03825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APA22_RS03830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APA22_RS03835	COG0540	Belongs to the ATCase OTCase family
APA22_RS03840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APA22_RS03845	COG0658	competence protein
APA22_RS03845	COG2333	competence protein COMEC
APA22_RS03850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APA22_RS03855	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APA22_RS03865	COG0508	dehydrogenase complex catalyzes the overall conversion of
APA22_RS03885	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APA22_RS03935	COG3260	NADH ubiquinone oxidoreductase 20
APA22_RS03940	COG1183	phosphatidylcholine synthase activity
APA22_RS03945	COG0688	phosphatidylethanolamine metabolic process
APA22_RS03950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APA22_RS03960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APA22_RS03960	COG2885	chlorophyll binding
APA22_RS03965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APA22_RS03975	COG4974	Belongs to the 'phage' integrase family
APA22_RS03980	COG0825	malonyl-CoA metabolic process
APA22_RS03985	COG1546	Belongs to the CinA family
APA22_RS03985	COG1058	Belongs to the CinA family
APA22_RS04005	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APA22_RS04010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APA22_RS04015	COG0181	hydroxymethylbilane synthase activity
APA22_RS04025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APA22_RS04030	COG0406	alpha-ribazole phosphatase activity
APA22_RS04040	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APA22_RS04060	COG0408	coproporphyrinogen oxidase activity
APA22_RS04065	COG2857	Cytochrome c1
APA22_RS04065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APA22_RS04070	COG2857	Cytochrome c1
APA22_RS04070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APA22_RS04075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APA22_RS04095	COG0778	Nitroreductase
APA22_RS04155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APA22_RS04170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APA22_RS04175	COG0582	viral genome integration into host DNA
APA22_RS04235	COG2963	transposase activity
APA22_RS04245	COG4372	Transposase
APA22_RS04340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APA22_RS04345	COG1902	pentaerythritol trinitrate reductase activity
APA22_RS04350	COG0640	Transcriptional regulator
APA22_RS04360	COG3591	Belongs to the peptidase S1B family
APA22_RS04365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APA22_RS04375	COG0019	diaminopimelate decarboxylase activity
APA22_RS04380	COG0165	Argininosuccinate lyase
APA22_RS04395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APA22_RS04400	COG0237	dephospho-CoA kinase activity
APA22_RS04405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APA22_RS04425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APA22_RS04435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APA22_RS04440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APA22_RS04450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APA22_RS04455	COG0248	Ppx GppA phosphatase
APA22_RS04470	COG1121	(ABC) transporter
APA22_RS04495	COG1289	transmembrane transporter activity
APA22_RS04500	COG1289	transmembrane transporter activity
APA22_RS04520	COG3088	subunit of a heme lyase
APA22_RS04525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APA22_RS04530	COG1138	Cytochrome C-type biogenesis protein
APA22_RS04535	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
APA22_RS04540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APA22_RS04575	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APA22_RS04605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APA22_RS04615	COG0477	Major facilitator Superfamily
APA22_RS04655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APA22_RS04660	COG0081	regulation of translation
APA22_RS04665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APA22_RS04670	COG0222	ribosome binding
APA22_RS04675	COG0085	RNA polymerase activity
APA22_RS04680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APA22_RS04685	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APA22_RS04690	COG0049	tRNA binding
APA22_RS04695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APA22_RS04700	COG0051	transcription antitermination factor activity, RNA binding
APA22_RS04705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APA22_RS04710	COG0088	Forms part of the polypeptide exit tunnel
APA22_RS04715	COG0089	rRNA binding
APA22_RS04720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APA22_RS04725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APA22_RS04730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APA22_RS04735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APA22_RS04740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APA22_RS04745	COG0255	Belongs to the universal ribosomal protein uL29 family
APA22_RS04750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APA22_RS04755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APA22_RS04760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APA22_RS04765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APA22_RS04770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APA22_RS04775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APA22_RS04780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APA22_RS04785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APA22_RS04790	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APA22_RS04795	COG1841	ribosomal large subunit assembly
APA22_RS04800	COG0200	Binds to the 23S rRNA
APA22_RS04810	COG0563	adenylate kinase activity
APA22_RS04815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APA22_RS04820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APA22_RS04825	COG0202	RNA polymerase activity
APA22_RS04830	COG0203	ribosomal protein L17
APA22_RS04840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APA22_RS04845	COG1116	anion transmembrane transporter activity
APA22_RS04870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APA22_RS04875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APA22_RS04880	COG0477	Major facilitator Superfamily
APA22_RS04885	COG3237	CsbD-like
APA22_RS04890	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APA22_RS04895	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APA22_RS04920	COG0714	Associated with various cellular activities
APA22_RS04930	COG0617	tRNA 3'-terminal CCA addition
APA22_RS04935	COG1132	(ABC) transporter
APA22_RS04945	COG2814	Major facilitator Superfamily
APA22_RS04950	COG1051	belongs to the nudix hydrolase family
APA22_RS04960	COG0793	Belongs to the peptidase S41A family
APA22_RS04970	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APA22_RS04975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APA22_RS04980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APA22_RS04985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APA22_RS04990	COG0505	Belongs to the CarA family
APA22_RS05000	COG0358	DNA primase activity
APA22_RS05005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APA22_RS05015	COG0360	Binds together with S18 to 16S ribosomal RNA
APA22_RS05020	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APA22_RS05025	COG0359	binds to the 23S rRNA
APA22_RS05030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APA22_RS05035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APA22_RS05045	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APA22_RS05065	COG1132	(ABC) transporter
APA22_RS05070	COG1802	Transcriptional regulator
APA22_RS05075	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APA22_RS05085	COG0850	regulation of cytokinetic process
APA22_RS05095	COG2081	HI0933 family
APA22_RS05100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APA22_RS05110	COG0457	Tetratricopeptide repeat
APA22_RS05110	COG0859	PFAM glycosyl transferase family 9
APA22_RS05115	COG1329	Transcriptional regulator
APA22_RS05120	COG3781	membrane
APA22_RS05125	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
APA22_RS05140	COG2884	Cell division ATP-binding protein ftsE
APA22_RS05155	COG3852	Histidine kinase
APA22_RS05175	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APA22_RS05180	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APA22_RS05200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APA22_RS05200	COG2010	Cytochrome c
APA22_RS05205	COG0246	Mannitol dehydrogenase
APA22_RS05210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APA22_RS05215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APA22_RS05220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APA22_RS05225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APA22_RS05225	COG0072	phenylalanine-tRNA ligase activity
APA22_RS05235	COG0747	negative chemotaxis
APA22_RS05255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APA22_RS05260	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APA22_RS05270	COG0473	3-isopropylmalate dehydrogenase activity
APA22_RS05275	COG0006	proline dipeptidase activity
APA22_RS05280	COG2264	protein methyltransferase activity
APA22_RS05285	COG0210	DNA helicase
APA22_RS05290	COG2003	Belongs to the UPF0758 family
APA22_RS05295	COG2003	Belongs to the UPF0758 family
APA22_RS05300	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APA22_RS05325	COG0071	Belongs to the small heat shock protein (HSP20) family
APA22_RS05330	COG0254	rRNA binding
APA22_RS05335	COG1970	mechanosensitive ion channel activity
APA22_RS05345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APA22_RS05350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APA22_RS05360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APA22_RS05360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APA22_RS05365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APA22_RS05375	COG0142	geranyltranstransferase activity
APA22_RS05380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APA22_RS05385	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APA22_RS05400	COG2062	phosphohistidine phosphatase, SixA
APA22_RS05405	COG1605	Chorismate mutase
APA22_RS05405	COG0287	Prephenate dehydrogenase
APA22_RS05430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APA22_RS05440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APA22_RS05450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APA22_RS05460	COG0729	surface antigen
APA22_RS05480	COG0322	excinuclease ABC activity
APA22_RS05495	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APA22_RS05500	COG0314	molybdopterin synthase activity
APA22_RS05505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APA22_RS05510	COG0156	8-amino-7-oxononanoate synthase activity
APA22_RS05520	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APA22_RS05520	COG4106	trans-aconitate 2-methyltransferase activity
APA22_RS05525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APA22_RS05535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APA22_RS05545	COG0148	phosphopyruvate hydratase activity
APA22_RS05565	COG2022	thiamine diphosphate biosynthetic process
APA22_RS05580	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APA22_RS05585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APA22_RS05605	COG0076	glutamate decarboxylase activity
APA22_RS05620	COG0484	heat shock protein binding
APA22_RS05625	COG0271	Belongs to the BolA IbaG family
APA22_RS05635	COG0321	lipoyl(octanoyl) transferase activity
APA22_RS05655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APA22_RS05660	COG2226	methyltransferase
APA22_RS05665	COG1040	competence protein
APA22_RS05685	COG2706	6-phosphogluconolactonase activity
APA22_RS05690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APA22_RS05695	COG0527	aspartate kinase activity
APA22_RS05700	COG2070	2-Nitropropane dioxygenase
APA22_RS05710	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APA22_RS05715	COG0124	histidyl-tRNA synthetase
APA22_RS05720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APA22_RS05730	COG2890	protein-(glutamine-N5) methyltransferase activity
APA22_RS05750	COG1968	undecaprenyl-diphosphatase activity
APA22_RS05755	COG0531	amino acid
APA22_RS05770	COG2951	lytic endotransglycosylase activity
APA22_RS05775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APA22_RS05780	COG1686	Belongs to the peptidase S11 family
APA22_RS05785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APA22_RS05800	COG0084	hydrolase, TatD family'
APA22_RS05815	COG0259	pyridoxamine-phosphate oxidase activity
APA22_RS05820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APA22_RS05825	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APA22_RS05830	COG1764	response to oxidative stress
APA22_RS05835	COG0579	oxidoreductase
APA22_RS05845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APA22_RS05850	COG0602	queuosine metabolic process
APA22_RS05855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APA22_RS05865	COG0175	sulfate reduction
APA22_RS05870	COG0175	sulfate reduction
APA22_RS05885	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APA22_RS05895	COG1519	Transferase
APA22_RS05900	COG1663	tetraacyldisaccharide 4'-kinase activity
APA22_RS05920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APA22_RS05925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APA22_RS05930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APA22_RS05940	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APA22_RS05985	COG1278	Cold shock
APA22_RS05990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APA22_RS05995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APA22_RS06000	COG0077	Prephenate dehydratase
APA22_RS06000	COG1605	Chorismate mutase
APA22_RS06005	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APA22_RS06010	COG3474	cytochrome
APA22_RS06020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APA22_RS06025	COG0606	chelatase, subunit chli
APA22_RS06030	COG0626	cystathionine gamma-synthase activity
APA22_RS06035	COG2897	thiosulfate sulfurtransferase activity
APA22_RS06040	COG0628	permease
APA22_RS06050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APA22_RS06055	COG0792	nuclease activity
APA22_RS06065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APA22_RS06070	COG0271	Belongs to the BolA IbaG family
APA22_RS06075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APA22_RS06080	COG0047	phosphoribosylformylglycinamidine synthase activity
APA22_RS06090	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APA22_RS06095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APA22_RS06100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APA22_RS06105	COG0861	Integral membrane protein TerC family
APA22_RS06120	COG1546	Belongs to the CinA family
APA22_RS06135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APA22_RS06140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APA22_RS06145	COG0508	dehydrogenase complex catalyzes the overall conversion of
APA22_RS06150	COG0022	dehydrogenase e1 component
APA22_RS06150	COG0508	dehydrogenase complex catalyzes the overall conversion of
APA22_RS06155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APA22_RS06160	COG0315	cyclic pyranopterin monophosphate synthase activity
APA22_RS06165	COG0134	indole-3-glycerol-phosphate synthase activity
APA22_RS06170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APA22_RS06180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APA22_RS06190	COG0149	triose-phosphate isomerase activity
APA22_RS06200	COG0504	CTP synthase activity
APA22_RS06205	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APA22_RS06215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APA22_RS06225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APA22_RS06230	COG0268	Binds directly to 16S ribosomal RNA
APA22_RS06235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APA22_RS06240	COG2226	methyltransferase
APA22_RS06245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APA22_RS06250	COG0756	dUTP diphosphatase activity
APA22_RS06255	COG1176	ABC-type spermidine putrescine transport system, permease component I
APA22_RS06260	COG1116	anion transmembrane transporter activity
APA22_RS06265	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APA22_RS06270	COG0525	valine-tRNA ligase activity
APA22_RS06285	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APA22_RS06310	COG1028	Short-chain dehydrogenase reductase Sdr
APA22_RS06315	COG0456	acetyltransferase
APA22_RS06320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APA22_RS06325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APA22_RS06330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APA22_RS06340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APA22_RS06345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APA22_RS06355	COG1349	DNA-binding transcription factor activity
APA22_RS06370	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APA22_RS06375	COG4988	ABC transporter
APA22_RS06400	COG0784	Response regulator, receiver
APA22_RS06405	COG0488	(ABC) transporter
APA22_RS06420	COG2824	Alkylphosphonate utilization operon protein PhnA
APA22_RS06425	COG0814	amino acid
APA22_RS06435	COG0384	phenazine biosynthesis protein PhzF
APA22_RS06455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APA22_RS06455	COG1116	anion transmembrane transporter activity
APA22_RS06485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
APA22_RS06510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APA22_RS06520	COG2233	PERMEase
APA22_RS06525	COG2351	hydroxyisourate hydrolase activity
APA22_RS06540	COG2072	flavoprotein involved in K transport
APA22_RS06550	COG0402	S-adenosylhomocysteine deaminase activity
APA22_RS06585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APA22_RS06590	COG1129	ABC transporter
APA22_RS06590	COG0842	Transport permease protein
APA22_RS06595	COG0842	Transport permease protein
APA22_RS06610	COG2855	membrane
APA22_RS06620	COG1657	PFAM Prenyltransferase squalene oxidase
APA22_RS06640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APA22_RS06645	COG1012	belongs to the aldehyde dehydrogenase family
APA22_RS06650	COG1902	pentaerythritol trinitrate reductase activity
APA22_RS06655	COG1733	regulation of RNA biosynthetic process
APA22_RS06660	COG0753	catalase activity
APA22_RS06715	COG4178	(ABC) transporter
APA22_RS06770	COG2814	Major facilitator Superfamily
APA22_RS06800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APA22_RS06805	COG0477	Major facilitator Superfamily
APA22_RS06820	COG0848	biopolymer transport protein
APA22_RS06840	COG3293	Transposase
APA22_RS06855	COG4774	siderophore transport
APA22_RS06865	COG4774	siderophore transport
APA22_RS06875	COG1595	DNA-templated transcription, initiation
APA22_RS06880	COG4774	siderophore transport
APA22_RS06900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APA22_RS06905	COG1116	anion transmembrane transporter activity
APA22_RS06910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APA22_RS06920	COG2175	clavaminate synthase activity
APA22_RS06940	COG3293	Transposase
APA22_RS06965	COG2271	Major facilitator Superfamily
APA22_RS06980	COG0583	DNA-binding transcription factor activity
APA22_RS07015	COG1454	alcohol dehydrogenase
APA22_RS07035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APA22_RS07040	COG1116	anion transmembrane transporter activity
APA22_RS07045	COG0864	Transcriptional regulator
APA22_RS07055	COG3665	Urea carboxylase-associated protein
APA22_RS07085	COG4771	TonB-dependent receptor
APA22_RS07095	COG4771	TonB-dependent receptor
APA22_RS07120	COG2211	Major facilitator Superfamily
APA22_RS07140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APA22_RS07155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APA22_RS07210	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APA22_RS07220	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APA22_RS07240	COG3436	PFAM IS66 Orf2 family protein
APA22_RS07245	COG4372	Transposase
APA22_RS07255	COG4372	Transposase
APA22_RS07305	COG1301	dicarboxylic acid transport
APA22_RS07310	COG0500	methyltransferase
APA22_RS07315	COG2999	glutathione oxidoreductase activity
APA22_RS07320	COG2814	Major facilitator Superfamily
APA22_RS07325	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
APA22_RS07375	COG0114	fumarate hydratase activity
APA22_RS07425	COG0628	permease
APA22_RS07450	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APA22_RS07450	COG1013	pyruvate-flavodoxin oxidoreductase activity
APA22_RS07450	COG0674	pyruvate-flavodoxin oxidoreductase activity
APA22_RS07450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APA22_RS07455	COG0493	'glutamate synthase
APA22_RS07470	COG1971	Probably functions as a manganese efflux pump
APA22_RS07480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APA22_RS07485	COG0746	molybdenum cofactor guanylyltransferase activity
APA22_RS07490	COG1763	Mo-molybdopterin cofactor biosynthetic process
APA22_RS07495	COG0303	'Molybdopterin
APA22_RS07500	COG3058	Necessary for formate dehydrogenase activity
APA22_RS07505	COG2864	formate dehydrogenase
APA22_RS07510	COG0437	4 iron, 4 sulfur cluster binding
APA22_RS07515	COG0243	molybdopterin cofactor binding
APA22_RS07515	COG3383	formate dehydrogenase (NAD+) activity
APA22_RS07525	COG0248	Ppx GppA phosphatase
APA22_RS07530	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APA22_RS07535	COG1940	carbohydrate kinase activity
APA22_RS07540	COG0425	Belongs to the sulfur carrier protein TusA family
APA22_RS07545	COG1722	exodeoxyribonuclease VII activity
APA22_RS07550	COG0142	geranyltranstransferase activity
APA22_RS07555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APA22_RS07560	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
APA22_RS07570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APA22_RS07575	COG0137	argininosuccinate synthase activity
APA22_RS07580	COG0545	Peptidyl-prolyl cis-trans isomerase
APA22_RS07590	COG0180	Tryptophanyl-tRNA synthetase
APA22_RS07605	COG0745	RESPONSE REGULATOR receiver
APA22_RS07620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APA22_RS07620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APA22_RS07635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APA22_RS07650	COG4608	Belongs to the ABC transporter superfamily
APA22_RS07655	COG2070	2-Nitropropane dioxygenase
APA22_RS07660	COG0671	phosphoesterase, PA-phosphatase related
APA22_RS07675	COG3511	phospholipase C
APA22_RS07700	COG0477	Major facilitator Superfamily
APA22_RS07715	COG1695	Transcriptional regulator
APA22_RS07730	COG1289	transmembrane transporter activity
APA22_RS07740	COG1032	radical SAM domain protein
APA22_RS07755	COG0668	transmembrane transport
APA22_RS07775	COG1294	oxidase, subunit
APA22_RS07780	COG1271	oxidase subunit
APA22_RS07785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APA22_RS07790	COG4988	ABC transporter
APA22_RS07800	COG3128	pkhd-type hydroxylase
APA22_RS07805	COG4774	siderophore transport
APA22_RS07825	COG0252	asparaginase activity
APA22_RS07835	COG2985	domain, Protein
APA22_RS07845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APA22_RS07870	COG0488	(ABC) transporter
APA22_RS07875	COG0583	DNA-binding transcription factor activity
APA22_RS07895	COG1064	alcohol dehydrogenase
APA22_RS07910	COG3685	Protein conserved in bacteria
APA22_RS07920	COG1285	pathogenesis
APA22_RS07945	COG0028	Belongs to the TPP enzyme family
APA22_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
APA22_RS07970	COG1028	Short-chain dehydrogenase reductase Sdr
APA22_RS07985	COG2814	Major facilitator Superfamily
APA22_RS08040	COG0642	Histidine kinase
APA22_RS08115	COG0318	PFAM AMP-dependent synthetase and ligase
APA22_RS08125	COG0156	8-amino-7-oxononanoate synthase activity
APA22_RS08140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APA22_RS08165	COG0546	phosphoglycolate phosphatase activity
APA22_RS08170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APA22_RS08175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APA22_RS08225	COG0386	Belongs to the glutathione peroxidase family
APA22_RS08230	COG1136	(ABC) transporter
APA22_RS08240	COG0442	prolyl-tRNA aminoacylation
APA22_RS08250	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APA22_RS08260	COG1007	ATP synthesis coupled electron transport
APA22_RS08270	COG0713	ATP synthesis coupled electron transport
APA22_RS08280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APA22_RS08285	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APA22_RS08290	COG1034	ATP synthesis coupled electron transport
APA22_RS08300	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APA22_RS08305	COG0649	NAD binding
APA22_RS08310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APA22_RS08315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APA22_RS08340	COG0776	regulation of translation
APA22_RS08350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APA22_RS08355	COG0740	serine-type endopeptidase activity
APA22_RS08360	COG0544	peptidyl-prolyl cis-trans isomerase activity
APA22_RS08370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APA22_RS08370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APA22_RS08385	COG0513	Belongs to the DEAD box helicase family
APA22_RS08395	COG0316	Belongs to the HesB IscA family
APA22_RS08400	COG2151	metal-sulfur cluster biosynthetic enzyme
APA22_RS08410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APA22_RS08415	COG0719	Fe-S assembly protein
APA22_RS08420	COG0396	ATPase activity
APA22_RS08425	COG0719	Fe-S assembly protein
APA22_RS08435	COG2733	membrane
APA22_RS08440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APA22_RS08450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APA22_RS08455	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APA22_RS08465	COG5265	(ABC) transporter
APA22_RS08475	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
APA22_RS08480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APA22_RS08505	COG0612	Peptidase, M16
APA22_RS08510	COG0312	modulator of DNA gyrase
APA22_RS08525	COG0109	protoheme IX farnesyltransferase activity
APA22_RS08535	COG2226	methyltransferase
APA22_RS08555	COG1522	sequence-specific DNA binding
APA22_RS08560	COG0492	ferredoxin-NADP+ reductase activity
APA22_RS08565	COG0583	DNA-binding transcription factor activity
APA22_RS08570	COG4957	zinc ion binding
APA22_RS08575	COG0776	regulation of translation
APA22_RS08605	COG0776	regulation of translation
APA22_RS08610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APA22_RS08615	COG0416	fatty acid biosynthetic process
APA22_RS08620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APA22_RS08640	COG0745	RESPONSE REGULATOR receiver
APA22_RS08645	COG1846	Transcriptional regulator
APA22_RS08655	COG0242	peptide deformylase activity
APA22_RS08660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APA22_RS08665	COG0473	3-isopropylmalate dehydrogenase activity
APA22_RS08670	COG0066	3-isopropylmalate dehydratase activity
APA22_RS08675	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APA22_RS08680	COG0335	large ribosomal subunit rRNA binding
APA22_RS08685	COG0336	Belongs to the RNA methyltransferase TrmD family
APA22_RS08690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APA22_RS08695	COG0228	four-way junction DNA binding
APA22_RS08720	COG0564	pseudouridine synthase activity
APA22_RS08725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APA22_RS08750	COG2814	Major facilitator Superfamily
APA22_RS08755	COG1160	GTP binding
APA22_RS08780	COG0438	transferase activity, transferring glycosyl groups
APA22_RS08785	COG0367	asparagine synthase
APA22_RS08790	COG0354	folic acid binding
APA22_RS08795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APA22_RS08800	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APA22_RS08805	COG0659	secondary active sulfate transmembrane transporter activity
APA22_RS08825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APA22_RS08835	COG1051	belongs to the nudix hydrolase family
APA22_RS08840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APA22_RS08845	COG1923	regulation of RNA biosynthetic process
APA22_RS08850	COG2204	response regulator
APA22_RS08875	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APA22_RS08875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APA22_RS08880	COG0463	Glycosyl transferase, family 2
APA22_RS08920	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APA22_RS08930	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APA22_RS08945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APA22_RS08955	COG0347	Belongs to the P(II) protein family
APA22_RS08965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APA22_RS08970	COG0586	Pfam SNARE associated Golgi protein
APA22_RS09005	COG3335	DDE superfamily endonuclease
APA22_RS09010	COG3547	Transposase (IS116 IS110 IS902 family)
APA22_RS09020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APA22_RS09025	COG0483	inositol monophosphate 1-phosphatase activity
APA22_RS09030	COG1199	ATP-dependent helicase activity
APA22_RS09035	COG1278	Cold shock
APA22_RS09040	COG0412	Dienelactone hydrolase
APA22_RS09045	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APA22_RS09050	COG0459	protein refolding
APA22_RS09060	COG2963	transposase activity
APA22_RS09070	COG4372	Transposase
APA22_RS09170	COG3293	Transposase
APA22_RS09225	COG4372	Transposase
APA22_RS09235	COG2963	transposase activity
APA22_RS09255	COG0004	ammonium transporteR
APA22_RS09275	COG4974	Belongs to the 'phage' integrase family
APA22_RS09285	COG1862	Preprotein translocase
APA22_RS09300	COG0494	nUDIX hydrolase
APA22_RS09320	COG2967	ApaG domain
APA22_RS09325	COG0302	gtp cyclohydrolase
APA22_RS09335	COG0521	Mo-molybdopterin cofactor biosynthetic process
APA22_RS09365	COG1566	PFAM secretion protein HlyD family protein
APA22_RS09395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APA22_RS09400	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APA22_RS09400	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APA22_RS09405	COG0307	riboflavin synthase, alpha
APA22_RS09415	COG2857	Cytochrome c1
APA22_RS09415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APA22_RS09420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APA22_RS09420	COG2857	Cytochrome c1
APA22_RS09425	COG0723	plastoquinol--plastocyanin reductase activity
APA22_RS09445	COG2252	PERMEase
APA22_RS09550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APA22_RS09555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APA22_RS09560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APA22_RS09565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APA22_RS09575	COG3750	Belongs to the UPF0335 family
APA22_RS09580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APA22_RS09590	COG0657	acetylesterase activity
APA22_RS09595	COG2001	Belongs to the MraZ family
APA22_RS09600	COG0275	rRNA processing
APA22_RS09615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APA22_RS09625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APA22_RS09630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APA22_RS09640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APA22_RS09645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APA22_RS09650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APA22_RS09655	COG1181	Belongs to the D-alanine--D-alanine ligase family
APA22_RS09660	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APA22_RS09665	COG0849	cell division
APA22_RS09675	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APA22_RS09680	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APA22_RS09685	COG0497	DNA recombination
APA22_RS09690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APA22_RS09695	COG0574	Belongs to the PEP-utilizing enzyme family
APA22_RS09695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APA22_RS09700	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
APA22_RS09725	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
APA22_RS09740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APA22_RS09745	COG1335	isochorismatase
APA22_RS09765	COG2132	Multicopper oxidase
APA22_RS09775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APA22_RS09785	COG0028	Belongs to the TPP enzyme family
APA22_RS09790	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APA22_RS09795	COG0560	Phosphoserine phosphatase
APA22_RS09795	COG3830	Belongs to the UPF0237 family
APA22_RS09810	COG0513	Belongs to the DEAD box helicase family
APA22_RS09830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APA22_RS09835	COG0531	amino acid
APA22_RS09840	COG0113	porphobilinogen synthase activity
APA22_RS09845	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
APA22_RS09850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APA22_RS09855	COG1381	Involved in DNA repair and RecF pathway recombination
APA22_RS09860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APA22_RS09865	COG0052	Belongs to the universal ribosomal protein uS2 family
APA22_RS09890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APA22_RS09900	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APA22_RS09905	COG0251	oxidation-reduction process
APA22_RS09920	COG0436	Aminotransferase
APA22_RS09925	COG0436	Aminotransferase
APA22_RS09930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APA22_RS09950	COG3161	chorismate lyase activity
APA22_RS09955	COG1032	radical SAM domain protein
APA22_RS09960	COG0105	UTP biosynthetic process
APA22_RS09965	COG0488	(ABC) transporter
APA22_RS09975	COG0745	RESPONSE REGULATOR receiver
APA22_RS09980	COG0642	Histidine kinase
APA22_RS09980	COG3850	Histidine kinase
APA22_RS09990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APA22_RS09995	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APA22_RS10015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APA22_RS10030	COG0328	RNA-DNA hybrid ribonuclease activity
APA22_RS10035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APA22_RS10040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APA22_RS10090	COG1530	ribonuclease E activity
APA22_RS10095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APA22_RS10100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APA22_RS10105	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APA22_RS10110	COG0424	maF-like protein
APA22_RS10120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
APA22_RS10400	COG0277	FAD linked oxidase domain protein
APA22_RS10415	COG2308	Evidence 4 Homologs of previously reported genes of
APA22_RS10440	COG1309	transcriptional regulator
APA22_RS10445	COG1252	NADH dehydrogenase
APA22_RS10450	COG1012	belongs to the aldehyde dehydrogenase family
APA22_RS10455	COG2814	Major facilitator Superfamily
APA22_RS10465	COG0431	NADPH-dependent FMN reductase
APA22_RS10475	COG0583	DNA-binding transcription factor activity
APA22_RS10510	COG0697	spore germination
APA22_RS10515	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APA22_RS10520	COG1984	allophanate hydrolase subunit 2
APA22_RS10530	COG4221	oxidoreductase activity
APA22_RS10535	COG0511	ligase activity, forming carbon-carbon bonds
APA22_RS10550	COG0436	Aminotransferase
APA22_RS10565	COG0300	oxidoreductase activity
APA22_RS10575	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APA22_RS10580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APA22_RS10585	COG0297	glycogen (starch) synthase activity
APA22_RS10600	COG1028	Short-chain dehydrogenase reductase Sdr
APA22_RS10605	COG0028	Belongs to the TPP enzyme family
APA22_RS10620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APA22_RS10625	COG1999	signal sequence binding
APA22_RS10690	COG0583	DNA-binding transcription factor activity
APA22_RS10695	COG1289	transmembrane transporter activity
APA22_RS10730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APA22_RS10735	COG0805	protein transport
APA22_RS10740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APA22_RS10745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APA22_RS10750	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APA22_RS10760	COG0018	arginyl-trna synthetase
APA22_RS10765	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APA22_RS10770	COG0316	Belongs to the HesB IscA family
APA22_RS10775	COG0708	Exodeoxyribonuclease III
APA22_RS10795	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APA22_RS10800	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
APA22_RS10810	COG0535	radical SAM domain protein
APA22_RS10820	COG0740	serine-type endopeptidase activity
APA22_RS10830	COG0436	Aminotransferase
APA22_RS10840	COG1494	fructose-1,6-bisphosphatase
APA22_RS10855	COG0564	pseudouridine synthase activity
APA22_RS10860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APA22_RS10865	COG1120	ATPase activity
APA22_RS10870	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APA22_RS10880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APA22_RS10885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APA22_RS10885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APA22_RS10915	COG1294	oxidase, subunit
APA22_RS10920	COG1271	oxidase subunit
APA22_RS10935	COG1113	amino acid transport
APA22_RS10945	COG4993	Dehydrogenase
APA22_RS10955	COG1942	4-Oxalocrotonate Tautomerase
APA22_RS10960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APA22_RS10965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APA22_RS10980	COG0493	'glutamate synthase
APA22_RS10985	COG4372	Transposase
APA22_RS10995	COG2963	transposase activity
APA22_RS11015	COG1953	Uracil, thiamine, allantoin
APA22_RS11030	COG0135	phosphoribosylanthranilate isomerase activity
APA22_RS11035	COG0284	orotidine-5'-phosphate decarboxylase activity
APA22_RS11045	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APA22_RS11055	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APA22_RS11060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APA22_RS11070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APA22_RS11095	COG3145	DNA-N1-methyladenine dioxygenase activity
APA22_RS11105	COG3620	sequence-specific DNA binding
APA22_RS11115	COG2011	ABC-type metal ion transport system permease component
APA22_RS11120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APA22_RS11130	COG0277	FAD linked oxidase domain protein
APA22_RS11135	COG1648	precorrin-2 dehydrogenase activity
APA22_RS11135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APA22_RS11150	COG1846	Transcriptional regulator
APA22_RS11155	COG0154	amidase activity
APA22_RS11160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APA22_RS11165	COG0235	Class ii aldolase
APA22_RS11190	COG4638	Rieske (2fe-2S)
APA22_RS11210	COG1012	belongs to the aldehyde dehydrogenase family
APA22_RS11235	COG1177	transmembrane transport
APA22_RS11240	COG1176	ABC-type spermidine putrescine transport system, permease component I
APA22_RS11250	COG3293	Transposase
APA22_RS11255	COG1176	ABC-type spermidine putrescine transport system, permease component I
APA22_RS11260	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APA22_RS11265	COG3842	ATPase activity
APA22_RS11270	COG1012	belongs to the aldehyde dehydrogenase family
APA22_RS11290	COG3128	pkhd-type hydroxylase
APA22_RS11305	COG4774	siderophore transport
APA22_RS11315	COG0848	biopolymer transport protein
APA22_RS11335	COG1301	dicarboxylic acid transport
APA22_RS11370	COG2814	Major facilitator Superfamily
APA22_RS11380	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
APA22_RS11385	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
APA22_RS11400	COG0778	Nitroreductase
APA22_RS11405	COG1492	cobalamin metabolic process
APA22_RS11420	COG1797	cobyrinic acid a,c-diamide synthase activity
APA22_RS11450	COG1289	transmembrane transporter activity
APA22_RS11455	COG1584	GPR1 FUN34 yaaH family protein
APA22_RS11460	COG1024	Enoyl-CoA hydratase
APA22_RS11465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APA22_RS11470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APA22_RS11485	COG0735	belongs to the Fur family
APA22_RS11500	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APA22_RS11520	COG0519	Catalyzes the synthesis of GMP from XMP
APA22_RS11520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APA22_RS11575	COG3293	Transposase
APA22_RS11640	COG2814	Major facilitator Superfamily
APA22_RS11645	COG0739	heme binding
APA22_RS11645	COG0741	lytic transglycosylase activity
APA22_RS11645	COG1196	nuclear chromosome segregation
APA22_RS11665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APA22_RS11675	COG1496	oxidoreductase activity
APA22_RS11705	COG1742	UPF0060 membrane protein
APA22_RS11720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APA22_RS11735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APA22_RS11740	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
APA22_RS11750	COG0363	glucosamine-6-phosphate deaminase activity
APA22_RS11755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APA22_RS11760	COG3265	gluconokinase activity
APA22_RS11785	COG1063	alcohol dehydrogenase
APA22_RS11795	COG3158	transport of potassium into the cell
APA22_RS11800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APA22_RS11825	COG0411	ABC transporter
APA22_RS11845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APA22_RS11845	COG2198	Histidine kinase
APA22_RS11845	COG0784	Response regulator, receiver
APA22_RS11845	COG2205	protein histidine kinase activity
APA22_RS11850	COG0745	RESPONSE REGULATOR receiver
APA22_RS11890	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APA22_RS11895	COG0830	nickel cation binding
APA22_RS11900	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
APA22_RS11905	COG0804	urea catabolic process
APA22_RS11910	COG0832	Belongs to the urease beta subunit family
APA22_RS11915	COG0831	urea catabolic process
APA22_RS11920	COG0829	nickel cation binding
APA22_RS11925	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
APA22_RS11930	COG3961	Belongs to the TPP enzyme family
APA22_RS11955	COG1393	Belongs to the ArsC family
APA22_RS11965	COG2818	Glycosylase
APA22_RS11975	COG0450	alkyl hydroperoxide reductase
APA22_RS12025	COG0583	DNA-binding transcription factor activity
APA22_RS12040	COG2271	Major facilitator Superfamily
APA22_RS12050	COG3473	Maleate cis-trans isomerase
APA22_RS12055	COG0596	Alpha beta hydrolase
APA22_RS12060	COG1335	isochorismatase
APA22_RS12065	COG2309	aminopeptidase activity
APA22_RS12070	COG2010	Cytochrome c
APA22_RS12070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APA22_RS12075	COG2080	2 iron, 2 sulfur cluster binding
APA22_RS12080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APA22_RS12085	COG1846	Transcriptional regulator
APA22_RS12105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APA22_RS12275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APA22_RS12285	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APA22_RS12305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APA22_RS12305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APA22_RS12310	COG0509	glycine decarboxylation via glycine cleavage system
APA22_RS12315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APA22_RS12320	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APA22_RS12325	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APA22_RS12350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APA22_RS12355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APA22_RS12370	COG1185	polyribonucleotide nucleotidyltransferase activity
APA22_RS12375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APA22_RS12380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APA22_RS12385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APA22_RS12390	COG1127	ABC transporter
APA22_RS12395	COG3008	intermembrane lipid transfer
APA22_RS12395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APA22_RS12440	COG1410	methionine synthase
APA22_RS12440	COG0646	methionine synthase
APA22_RS12455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APA22_RS12465	COG3008	intermembrane lipid transfer
APA22_RS12470	COG2995	paraquat-inducible protein a
APA22_RS12480	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APA22_RS12485	COG0463	Glycosyl transferase, family 2
APA22_RS12490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APA22_RS12495	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APA22_RS12500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APA22_RS12505	COG0356	it plays a direct role in the translocation of protons across the membrane
APA22_RS12515	COG0552	protein localization to endoplasmic reticulum
APA22_RS12520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APA22_RS12525	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APA22_RS12530	COG0346	lactoylglutathione lyase activity
APA22_RS12540	COG0513	Belongs to the DEAD box helicase family
APA22_RS12560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APA22_RS12575	COG0704	Plays a role in the regulation of phosphate uptake
APA22_RS12580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APA22_RS12590	COG0573	inorganic phosphate transmembrane transporter activity
APA22_RS12595	COG0129	dihydroxy-acid dehydratase activity
APA22_RS12630	COG0489	protein tyrosine kinase activity
APA22_RS12645	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
APA22_RS12655	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APA22_RS12655	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APA22_RS12670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APA22_RS12675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APA22_RS12680	COG1522	sequence-specific DNA binding
APA22_RS12685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APA22_RS12690	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APA22_RS12705	COG0779	Required for maturation of 30S ribosomal subunits
APA22_RS12715	COG0542	response to heat
APA22_RS12730	COG0765	amino acid transport
APA22_RS12735	COG1126	abc transporter atp-binding protein
APA22_RS12745	COG4133	protoheme IX ABC transporter activity
APA22_RS12765	COG1295	ribonuclease BN
APA22_RS12775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APA22_RS12780	COG0511	ligase activity, forming carbon-carbon bonds
APA22_RS12785	COG0439	Biotin carboxylase
APA22_RS12790	COG2814	Major facilitator Superfamily
APA22_RS12795	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APA22_RS12810	COG0672	)-iron permease
APA22_RS12845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APA22_RS12855	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APA22_RS12860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APA22_RS12865	COG0154	amidase activity
APA22_RS12870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APA22_RS12880	COG5265	(ABC) transporter
APA22_RS12885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APA22_RS12890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APA22_RS12895	COG1194	a g-specific adenine glycosylase
APA22_RS12920	COG0495	leucyl-tRNA aminoacylation
APA22_RS12995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APA22_RS13005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APA22_RS13010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APA22_RS13015	COG0590	tRNA wobble adenosine to inosine editing
APA22_RS13020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APA22_RS13025	COG1187	pseudouridine synthase activity
APA22_RS13030	COG0742	ribosomal rna small subunit methyltransferase
APA22_RS13035	COG0629	single-stranded DNA binding
APA22_RS13090	COG3293	Transposase
APA22_RS13095	COG0438	transferase activity, transferring glycosyl groups
APA22_RS13105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APA22_RS13110	COG0312	modulator of DNA gyrase
APA22_RS13115	COG0406	alpha-ribazole phosphatase activity
APA22_RS13135	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
APA22_RS13140	COG1091	dTDP-4-dehydrorhamnose reductase activity
APA22_RS13150	COG1674	ftsk spoiiie
APA22_RS13155	COG0564	pseudouridine synthase activity
APA22_RS13170	COG0482	sulfurtransferase activity
APA22_RS13180	COG1104	cysteine desulfurase activity
APA22_RS13185	COG1104	cysteine desulfurase activity
APA22_RS13190	COG2945	thiolester hydrolase activity
APA22_RS13200	COG0215	cysteine-tRNA ligase activity
APA22_RS13210	COG0285	dihydrofolate synthase activity
APA22_RS13215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APA22_RS13230	COG2887	Belongs to the helicase family. UvrD subfamily
APA22_RS13235	COG0802	atpase or kinase
APA22_RS13245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APA22_RS13255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APA22_RS13260	COG0037	tRNA processing
APA22_RS13270	COG2885	chlorophyll binding
APA22_RS13275	COG0823	Involved in the tonB-independent uptake of proteins
APA22_RS13285	COG0848	biopolymer transport protein
APA22_RS13295	COG0824	Thioesterase
APA22_RS13300	COG2255	four-way junction helicase activity
APA22_RS13305	COG0632	four-way junction helicase activity
APA22_RS13310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APA22_RS13315	COG0217	transcriptional regulatory protein
APA22_RS13320	COG0653	protein targeting
APA22_RS13325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APA22_RS13330	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APA22_RS13340	COG0668	transmembrane transport
APA22_RS13355	COG0484	heat shock protein binding
APA22_RS13390	COG0776	regulation of translation
APA22_RS13410	COG1216	Glycosyl transferase, family 2
APA22_RS13425	COG0131	Imidazoleglycerol-phosphate dehydratase
APA22_RS13430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APA22_RS13435	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APA22_RS13440	COG0107	imidazoleglycerol-phosphate synthase activity
APA22_RS13445	COG0140	phosphoribosyl-ATP diphosphatase activity
APA22_RS13455	COG0778	Nitroreductase
APA22_RS13495	COG0357	Ribosomal RNA small subunit methyltransferase G
APA22_RS13500	COG0445	tRNA wobble uridine modification
APA22_RS13505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APA22_RS13510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APA22_RS13540	COG1611	Belongs to the LOG family
APA22_RS13555	COG1981	membrane
APA22_RS13560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APA22_RS13565	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APA22_RS13570	COG0424	maF-like protein
APA22_RS13650	COG0210	DNA helicase
APA22_RS13660	COG3547	Transposase (IS116 IS110 IS902 family)
APA22_RS13665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APA22_RS13675	COG0246	Mannitol dehydrogenase
APA22_RS13785	COG1192	Involved in chromosome partitioning
APA22_RS13790	COG1475	DNA binding
APA22_RS13805	COG0776	regulation of translation
APA22_RS13845	COG1309	transcriptional regulator
APA22_RS13850	COG1979	alcohol dehydrogenase
APA22_RS13855	COG1012	belongs to the aldehyde dehydrogenase family
APA22_RS13885	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APA22_RS13890	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APA22_RS13895	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
APA22_RS13900	COG2205	protein histidine kinase activity
APA22_RS13905	COG0745	RESPONSE REGULATOR receiver
APA22_RS13930	COG3551	Protein conserved in bacteria
APA22_RS13955	COG0640	Transcriptional regulator
APA22_RS13970	COG0584	glycerophosphoryl diester phosphodiesterase
APA22_RS13985	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APA22_RS14055	COG1914	H( )-stimulated, divalent metal cation uptake system
APA22_RS14060	COG1321	iron dependent repressor
APA22_RS14150	COG1203	CRISPR-associated helicase, Cas3
APA22_RS14165	COG1857	crispr-associated protein
APA22_RS14180	COG1518	maintenance of DNA repeat elements
APA22_RS14185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APA22_RS14265	COG3077	Addiction module antitoxin, RelB DinJ family
APA22_RS14270	COG2026	Addiction module toxin, RelE StbE family
APA22_RS14280	COG4716	Myosin-crossreactive antigen
APA22_RS14385	COG2337	Toxic component of a toxin-antitoxin (TA) module
APA22_RS14390	COG2336	PFAM SpoVT AbrB
APA22_RS14430	COG1028	Short-chain dehydrogenase reductase Sdr
APA22_RS14440	COG2072	flavoprotein involved in K transport
APA22_RS14455	COG2144	transferase activity, transferring acyl groups
APA22_RS14480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APA22_RS14490	COG0583	DNA-binding transcription factor activity
APA22_RS14515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APA22_RS14560	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APA22_RS14575	COG0732	type I restriction modification DNA specificity domain
APA22_RS14580	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
APA22_RS14590	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APA22_RS14595	COG1902	pentaerythritol trinitrate reductase activity
APA22_RS14635	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
APA22_RS14645	COG1012	belongs to the aldehyde dehydrogenase family
APA22_RS14650	COG2072	flavoprotein involved in K transport
APA22_RS14670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APA22_RS14670	COG1116	anion transmembrane transporter activity
APA22_RS14680	COG0243	molybdopterin cofactor binding
APA22_RS14690	COG0243	molybdopterin cofactor binding
APA22_RS14695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APA22_RS14695	COG2146	nitrite reductase [NAD(P)H] activity
APA22_RS14700	COG2146	nitrite reductase [NAD(P)H] activity
APA22_RS14700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APA22_RS14720	COG0642	Histidine kinase
APA22_RS14775	COG0583	DNA-binding transcription factor activity
APA22_RS14780	COG3293	Transposase
APA22_RS14795	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
APA22_RS14800	COG2072	flavoprotein involved in K transport
APA22_RS14805	COG0431	NADPH-dependent FMN reductase
APA22_RS14810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APA22_RS14830	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APA22_RS14870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APA22_RS14890	COG0583	DNA-binding transcription factor activity
APA22_RS14925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APA22_RS14945	COG3158	transport of potassium into the cell
APA22_RS14960	COG3158	transport of potassium into the cell
APA22_RS15070	COG4221	oxidoreductase activity
APA22_RS15140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APA22_RS15170	COG0789	Transcriptional regulator
APA22_RS15185	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APA22_RS15190	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APA22_RS15195	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
APA22_RS15200	COG2205	protein histidine kinase activity
APA22_RS15205	COG0745	RESPONSE REGULATOR receiver
APA22_RS15215	COG1028	Short-chain dehydrogenase reductase Sdr
APA22_RS15240	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APA22_RS15320	COG2801	Transposase and inactivated derivatives
APA22_RS15320	COG3415	Transposase
APA22_RS15355	COG3293	Transposase
APA22_RS15365	COG4974	Belongs to the 'phage' integrase family
APA22_RS15420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APA22_RS15565	COG4691	Plasmid stability protein
APA22_RS15570	COG1487	ribonuclease activity
APA22_RS15600	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
APA22_RS15610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APA22_RS15625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APA22_RS15630	COG1061	Type III restriction enzyme res subunit
APA22_RS15635	COG1002	Type II restriction enzyme, methylase subunits
APA22_RS15695	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system