locus-tag	class	description
HN018_RS00005	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HN018_RS00015	COG2079	MmgE PrpD family protein
HN018_RS00035	COG3191	aminopeptidase activity
HN018_RS00040	COG2205	protein histidine kinase activity
HN018_RS00045	COG0745	RESPONSE REGULATOR receiver
HN018_RS00050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HN018_RS00055	COG0443	Heat shock 70 kDa protein
HN018_RS00060	COG0484	heat shock protein binding
HN018_RS00065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HN018_RS00070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HN018_RS00075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HN018_RS00085	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN018_RS00090	COG0628	permease
HN018_RS00130	COG1216	Glycosyl transferase, family 2
HN018_RS00130	COG0438	transferase activity, transferring glycosyl groups
HN018_RS00140	COG1657	PFAM Prenyltransferase squalene oxidase
HN018_RS00145	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HN018_RS00150	COG1562	ergosterol biosynthetic process
HN018_RS00155	COG1562	ergosterol biosynthetic process
HN018_RS00165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_RS00180	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS00185	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS00195	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS00200	COG1129	ABC transporter
HN018_RS00205	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS00210	COG2140	Oxalate decarboxylase
HN018_RS00215	COG0800	Aldolase
HN018_RS00225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_RS00230	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HN018_RS00235	COG1737	Transcriptional regulator
HN018_RS00245	COG0287	Prephenate dehydrogenase
HN018_RS00265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HN018_RS00270	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
HN018_RS00275	COG0535	radical SAM domain protein
HN018_RS00280	COG0535	radical SAM domain protein
HN018_RS00335	COG1215	transferase activity, transferring glycosyl groups
HN018_RS00350	COG4953	penicillin-binding protein 1C
HN018_RS00365	COG2983	Belongs to the UPF0260 family
HN018_RS00380	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HN018_RS00435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HN018_RS00440	COG2204	response regulator
HN018_RS00445	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HN018_RS00455	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HN018_RS00475	COG1749	Flagellar hook protein flgE
HN018_RS00510	COG0542	response to heat
HN018_RS00550	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HN018_RS00580	COG1472	Belongs to the glycosyl hydrolase 3 family
HN018_RS00620	COG0438	transferase activity, transferring glycosyl groups
HN018_RS00625	COG0463	Glycosyl transferase, family 2
HN018_RS00635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN018_RS00645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HN018_RS00665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN018_RS00670	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HN018_RS00670	COG2273	Hydrolase Family 16
HN018_RS00675	COG1216	Glycosyl transferase, family 2
HN018_RS00680	COG3206	protein involved in exopolysaccharide biosynthesis
HN018_RS00680	COG0489	protein tyrosine kinase activity
HN018_RS00685	COG3307	-O-antigen
HN018_RS00700	COG2199	diguanylate cyclase activity
HN018_RS00700	COG2200	EAL domain
HN018_RS00705	COG3436	PFAM IS66 Orf2 family protein
HN018_RS00765	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HN018_RS00770	COG0642	Histidine kinase
HN018_RS00775	COG0745	RESPONSE REGULATOR receiver
HN018_RS00825	COG0745	RESPONSE REGULATOR receiver
HN018_RS00830	COG2205	protein histidine kinase activity
HN018_RS00855	COG0438	transferase activity, transferring glycosyl groups
HN018_RS00865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HN018_RS00880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HN018_RS00885	COG1183	phosphatidylcholine synthase activity
HN018_RS00925	COG1129	ABC transporter
HN018_RS00930	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS00935	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS00945	COG3938	Belongs to the proline racemase family
HN018_RS00950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HN018_RS00960	COG0531	amino acid
HN018_RS00995	COG2814	Major facilitator Superfamily
HN018_RS01000	COG2211	Major facilitator Superfamily
HN018_RS01090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HN018_RS01110	COG2390	Transcriptional regulator
HN018_RS01120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN018_RS01125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HN018_RS01135	COG0747	negative chemotaxis
HN018_RS01145	COG0601	transmembrane transport
HN018_RS01160	COG1126	abc transporter atp-binding protein
HN018_RS01180	COG2072	flavoprotein involved in K transport
HN018_RS01205	COG0829	nickel cation binding
HN018_RS01210	COG0831	urea catabolic process
HN018_RS01215	COG0832	Belongs to the urease beta subunit family
HN018_RS01220	COG0804	urea catabolic process
HN018_RS01225	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HN018_RS01230	COG0830	nickel cation binding
HN018_RS01235	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HN018_RS01240	COG2186	Transcriptional regulator
HN018_RS01245	COG1063	alcohol dehydrogenase
HN018_RS01250	COG1349	DNA-binding transcription factor activity
HN018_RS01265	COG1175	transmembrane transport
HN018_RS01275	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS01295	COG2376	Dihydroxyacetone kinase
HN018_RS01300	COG0698	ribose 5-phosphate isomerase
HN018_RS01305	COG0149	triose-phosphate isomerase activity
HN018_RS01310	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN018_RS01315	COG1024	Enoyl-CoA hydratase
HN018_RS01320	COG0633	Ferredoxin
HN018_RS01325	COG5001	Diguanylate cyclase
HN018_RS01355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HN018_RS01360	COG0753	catalase activity
HN018_RS01365	COG0583	DNA-binding transcription factor activity
HN018_RS01425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HN018_RS01440	COG0737	Belongs to the 5'-nucleotidase family
HN018_RS01450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HN018_RS01460	COG1216	Glycosyl transferase, family 2
HN018_RS01460	COG0438	transferase activity, transferring glycosyl groups
HN018_RS01475	COG1216	Glycosyl transferase, family 2
HN018_RS01475	COG0438	transferase activity, transferring glycosyl groups
HN018_RS01485	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HN018_RS01490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HN018_RS01525	COG2853	Lipoprotein
HN018_RS01550	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
HN018_RS01550	COG0028	Belongs to the TPP enzyme family
HN018_RS01565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HN018_RS01580	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HN018_RS01600	COG0284	orotidine-5'-phosphate decarboxylase activity
HN018_RS01605	COG0135	phosphoribosylanthranilate isomerase activity
HN018_RS01635	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS01640	COG1129	ABC transporter
HN018_RS01650	COG1063	alcohol dehydrogenase
HN018_RS01655	COG1461	Dihydroxyacetone kinase
HN018_RS01660	COG2376	Dihydroxyacetone kinase
HN018_RS01665	COG2390	Transcriptional regulator
HN018_RS01670	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HN018_RS01680	COG1764	response to oxidative stress
HN018_RS01685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HN018_RS01700	COG0431	NADPH-dependent FMN reductase
HN018_RS01705	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HN018_RS01725	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HN018_RS01745	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HN018_RS01770	COG2815	serine threonine protein kinase
HN018_RS01770	COG0515	serine threonine protein kinase
HN018_RS01775	COG2223	nitrite transmembrane transporter activity
HN018_RS01780	COG0243	molybdopterin cofactor binding
HN018_RS01790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HN018_RS01800	COG0443	Heat shock 70 kDa protein
HN018_RS01820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HN018_RS01825	COG3047	cAMP biosynthetic process
HN018_RS01845	COG0741	lytic transglycosylase activity
HN018_RS01850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HN018_RS01870	COG3842	ATPase activity
HN018_RS01875	COG2202	Pas domain
HN018_RS01875	COG3920	Histidine kinase
HN018_RS01900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HN018_RS01905	COG0307	riboflavin synthase, alpha
HN018_RS01910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HN018_RS01910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HN018_RS01915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HN018_RS01915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HN018_RS01920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HN018_RS01935	COG3706	GGDEF domain
HN018_RS01955	COG1295	ribonuclease BN
HN018_RS01970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HN018_RS02005	COG2814	Major facilitator Superfamily
HN018_RS02010	COG0596	Alpha beta hydrolase
HN018_RS02015	COG1573	uracil-dna glycosylase
HN018_RS02025	COG2942	2-epimerase
HN018_RS02035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HN018_RS02050	COG0469	pyruvate kinase activity
HN018_RS02065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HN018_RS02070	COG0625	glutathione transferase activity
HN018_RS02075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HN018_RS02080	COG0492	ferredoxin-NADP+ reductase activity
HN018_RS02090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HN018_RS02095	COG2887	Belongs to the helicase family. UvrD subfamily
HN018_RS02100	COG1074	ATP-dependent DNA helicase activity
HN018_RS02105	COG3118	belongs to the thioredoxin family
HN018_RS02120	COG3394	polysaccharide catabolic process
HN018_RS02140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HN018_RS02145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HN018_RS02155	COG1609	Transcriptional regulator
HN018_RS02160	COG1129	ABC transporter
HN018_RS02180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_RS02190	COG0235	Class ii aldolase
HN018_RS02195	COG2084	Dehydrogenase
HN018_RS02200	COG3622	Belongs to the hyi family
HN018_RS02205	COG3395	kinase activity
HN018_RS02255	COG4964	Belongs to the GSP D family
HN018_RS02295	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HN018_RS02300	COG4133	protoheme IX ABC transporter activity
HN018_RS02315	COG0765	amino acid transport
HN018_RS02320	COG1846	Transcriptional regulator
HN018_RS02325	COG1764	response to oxidative stress
HN018_RS02340	COG1012	belongs to the aldehyde dehydrogenase family
HN018_RS02350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_RS02355	COG0779	Required for maturation of 30S ribosomal subunits
HN018_RS02370	COG5373	membrane
HN018_RS02370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HN018_RS02375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HN018_RS02390	COG4948	Mandelate Racemase Muconate Lactonizing
HN018_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS02400	COG1129	ABC transporter
HN018_RS02405	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS02420	COG4154	Belongs to the RbsD FucU family
HN018_RS02425	COG0339	signal peptide processing
HN018_RS02465	COG0667	Aldo Keto reductase
HN018_RS02510	COG2205	protein histidine kinase activity
HN018_RS02525	COG0659	secondary active sulfate transmembrane transporter activity
HN018_RS02545	COG0778	Nitroreductase
HN018_RS02580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HN018_RS02585	COG1396	sequence-specific DNA binding
HN018_RS02595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HN018_RS02600	COG1053	succinate dehydrogenase
HN018_RS02625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HN018_RS02635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HN018_RS02650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HN018_RS02655	COG0039	L-malate dehydrogenase activity
HN018_RS02660	COG0567	Dehydrogenase, E1 component
HN018_RS02665	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_RS02675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HN018_RS02680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HN018_RS02685	COG0667	Aldo Keto reductase
HN018_RS02695	COG0477	Major facilitator Superfamily
HN018_RS02740	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS02755	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HN018_RS02755	COG2010	Cytochrome c
HN018_RS02775	COG1309	transcriptional regulator
HN018_RS02785	COG2995	paraquat-inducible protein a
HN018_RS02790	COG3008	intermembrane lipid transfer
HN018_RS02935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HN018_RS02945	COG1609	Transcriptional regulator
HN018_RS02955	COG1129	ABC transporter
HN018_RS02965	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS02975	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
HN018_RS02990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HN018_RS02995	COG0347	Belongs to the P(II) protein family
HN018_RS03000	COG0004	ammonium transporteR
HN018_RS03010	COG4771	TonB-dependent receptor
HN018_RS03020	COG4974	Belongs to the 'phage' integrase family
HN018_RS03045	COG4946	Tricorn protease homolog
HN018_RS03045	COG0823	Involved in the tonB-independent uptake of proteins
HN018_RS03045	COG1506	peptidase
HN018_RS03055	COG4946	Tricorn protease homolog
HN018_RS03055	COG0793	Belongs to the peptidase S41A family
HN018_RS03075	COG3275	phosphorelay sensor kinase activity
HN018_RS03085	COG2244	polysaccharide biosynthetic process
HN018_RS03095	COG1105	Belongs to the carbohydrate kinase PfkB family
HN018_RS03105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HN018_RS03110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HN018_RS03115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HN018_RS03120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HN018_RS03125	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HN018_RS03130	COG2203	Gaf domain
HN018_RS03130	COG4251	negative regulation of phosphorylation
HN018_RS03130	COG5001	Diguanylate cyclase
HN018_RS03130	COG3706	GGDEF domain
HN018_RS03135	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HN018_RS03145	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HN018_RS03150	COG0602	queuosine metabolic process
HN018_RS03160	COG0667	Aldo Keto reductase
HN018_RS03175	COG0673	inositol 2-dehydrogenase activity
HN018_RS03195	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HN018_RS03225	COG0251	oxidation-reduction process
HN018_RS03245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN018_RS03260	COG0783	Belongs to the Dps family
HN018_RS03330	COG2372	response to copper ion
HN018_RS03350	COG2132	Multicopper oxidase
HN018_RS03385	COG0583	DNA-binding transcription factor activity
HN018_RS03390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HN018_RS03405	COG0601	transmembrane transport
HN018_RS03410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HN018_RS03415	COG0444	Belongs to the ABC transporter superfamily
HN018_RS03420	COG4608	Belongs to the ABC transporter superfamily
HN018_RS03425	COG2072	flavoprotein involved in K transport
HN018_RS03435	COG4772	TonB-dependent receptor
HN018_RS03455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HN018_RS03505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HN018_RS03510	COG1349	DNA-binding transcription factor activity
HN018_RS03515	COG0747	negative chemotaxis
HN018_RS03525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HN018_RS03530	COG0444	Belongs to the ABC transporter superfamily
HN018_RS03535	COG4608	Belongs to the ABC transporter superfamily
HN018_RS03545	COG0402	S-adenosylhomocysteine deaminase activity
HN018_RS03555	COG4771	TonB-dependent receptor
HN018_RS03560	COG1176	ABC-type spermidine putrescine transport system, permease component I
HN018_RS03565	COG1177	transmembrane transport
HN018_RS03570	COG3842	ATPase activity
HN018_RS03580	COG4644	lycopene metabolic process
HN018_RS03605	COG0745	RESPONSE REGULATOR receiver
HN018_RS03625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HN018_RS03625	COG2124	cytochrome p450
HN018_RS03630	COG2855	membrane
HN018_RS03635	COG0583	DNA-binding transcription factor activity
HN018_RS03700	COG3300	MHYT domain
HN018_RS03700	COG5001	Diguanylate cyclase
HN018_RS03720	COG1595	DNA-templated transcription, initiation
HN018_RS03735	COG2706	6-phosphogluconolactonase activity
HN018_RS03755	COG4584	PFAM Integrase catalytic
HN018_RS03760	COG1484	DNA-dependent DNA replication
HN018_RS03775	COG0025	NhaP-type Na H and K H
HN018_RS03800	COG3059	membrane
HN018_RS03805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HN018_RS03830	COG0583	DNA-binding transcription factor activity
HN018_RS03835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN018_RS03835	COG0604	alcohol dehydrogenase
HN018_RS03835	COG3321	synthase
HN018_RS03835	COG4221	oxidoreductase activity
HN018_RS03840	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS03880	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS03885	COG0604	alcohol dehydrogenase
HN018_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS03885	COG3321	synthase
HN018_RS03890	COG0596	Alpha beta hydrolase
HN018_RS03900	COG0583	DNA-binding transcription factor activity
HN018_RS03905	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS03920	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS03925	COG4206	TonB-dependent receptor
HN018_RS03935	COG0444	Belongs to the ABC transporter superfamily
HN018_RS03945	COG0673	inositol 2-dehydrogenase activity
HN018_RS03960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HN018_RS03965	COG0601	transmembrane transport
HN018_RS03975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_RS04025	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS04045	COG0436	Aminotransferase
HN018_RS04075	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HN018_RS04080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HN018_RS04105	COG0583	DNA-binding transcription factor activity
HN018_RS04125	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HN018_RS04130	COG0183	Belongs to the thiolase family
HN018_RS04135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HN018_RS04145	COG1414	Transcriptional regulator
HN018_RS04150	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS04175	COG3485	protocatechuate 3,4-dioxygenase
HN018_RS04185	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS04190	COG1129	ABC transporter
HN018_RS04200	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS04205	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS04215	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS04220	COG1063	alcohol dehydrogenase
HN018_RS04225	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS04235	COG1129	ABC transporter
HN018_RS04240	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS04250	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HN018_RS04255	COG1609	Transcriptional regulator
HN018_RS04295	COG1802	Transcriptional regulator
HN018_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS04330	COG0183	Belongs to the thiolase family
HN018_RS04365	COG1129	ABC transporter
HN018_RS04370	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS04380	COG1063	alcohol dehydrogenase
HN018_RS04395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_RS04400	COG0800	Aldolase
HN018_RS04445	COG4964	Belongs to the GSP D family
HN018_RS04475	COG0745	RESPONSE REGULATOR receiver
HN018_RS04490	COG0604	alcohol dehydrogenase
HN018_RS04495	COG1309	transcriptional regulator
HN018_RS04520	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HN018_RS04530	COG1733	regulation of RNA biosynthetic process
HN018_RS04535	COG2271	Major facilitator Superfamily
HN018_RS04545	COG0436	Aminotransferase
HN018_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS04555	COG0435	Glutathione S-transferase
HN018_RS04575	COG2271	Major facilitator Superfamily
HN018_RS04590	COG0167	dihydroorotate dehydrogenase activity
HN018_RS04605	COG1678	Uncharacterized ACR, COG1678
HN018_RS04615	COG4221	oxidoreductase activity
HN018_RS04620	COG2326	polyphosphate kinase activity
HN018_RS04650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HN018_RS04655	COG1686	Belongs to the peptidase S11 family
HN018_RS04660	COG0024	Methionine aminopeptidase
HN018_RS04670	COG0861	Integral membrane protein TerC family
HN018_RS04675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HN018_RS04685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HN018_RS04700	COG0047	phosphoribosylformylglycinamidine synthase activity
HN018_RS04705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HN018_RS04725	COG0792	nuclease activity
HN018_RS04740	COG0628	permease
HN018_RS04750	COG2897	thiosulfate sulfurtransferase activity
HN018_RS04755	COG0626	cystathionine gamma-synthase activity
HN018_RS04770	COG0606	chelatase, subunit chli
HN018_RS04775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_RS04780	COG1733	regulation of RNA biosynthetic process
HN018_RS04795	COG3474	cytochrome
HN018_RS04810	COG4774	siderophore transport
HN018_RS04815	COG2816	NAD+ diphosphatase activity
HN018_RS04830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HN018_RS04835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HN018_RS04845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HN018_RS04850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HN018_RS04855	COG3546	catalase activity
HN018_RS04860	COG3685	Protein conserved in bacteria
HN018_RS04865	COG3161	chorismate lyase activity
HN018_RS04875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HN018_RS04880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HN018_RS04885	COG0539	negative regulation of cytoplasmic translation
HN018_RS04900	COG5508	conserved small protein
HN018_RS04910	COG3088	subunit of a heme lyase
HN018_RS04915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN018_RS04920	COG1138	Cytochrome C-type biogenesis protein
HN018_RS04925	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HN018_RS04935	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HN018_RS04990	COG2140	Oxalate decarboxylase
HN018_RS04995	COG0583	DNA-binding transcription factor activity
HN018_RS05005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HN018_RS05010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HN018_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS05065	COG0745	RESPONSE REGULATOR receiver
HN018_RS05070	COG2205	protein histidine kinase activity
HN018_RS05085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN018_RS05095	COG0438	transferase activity, transferring glycosyl groups
HN018_RS05110	COG0438	transferase activity, transferring glycosyl groups
HN018_RS05115	COG2376	Dihydroxyacetone kinase
HN018_RS05120	COG1129	ABC transporter
HN018_RS05125	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS05130	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS05135	COG1349	DNA-binding transcription factor activity
HN018_RS05140	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS05150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HN018_RS05155	COG0081	regulation of translation
HN018_RS05160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HN018_RS05165	COG0222	ribosome binding
HN018_RS05170	COG0085	RNA polymerase activity
HN018_RS05175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HN018_RS05180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HN018_RS05185	COG0049	tRNA binding
HN018_RS05190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HN018_RS05195	COG0051	transcription antitermination factor activity, RNA binding
HN018_RS05200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HN018_RS05205	COG0088	Forms part of the polypeptide exit tunnel
HN018_RS05210	COG0089	rRNA binding
HN018_RS05215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HN018_RS05220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HN018_RS05225	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HN018_RS05230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HN018_RS05235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HN018_RS05240	COG0255	Belongs to the universal ribosomal protein uL29 family
HN018_RS05245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HN018_RS05250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HN018_RS05255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HN018_RS05260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HN018_RS05265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HN018_RS05270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HN018_RS05275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HN018_RS05280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HN018_RS05285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HN018_RS05290	COG1841	ribosomal large subunit assembly
HN018_RS05295	COG0200	Binds to the 23S rRNA
HN018_RS05300	COG0201	protein transport
HN018_RS05305	COG0563	adenylate kinase activity
HN018_RS05310	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HN018_RS05315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HN018_RS05320	COG0202	RNA polymerase activity
HN018_RS05325	COG0203	ribosomal protein L17
HN018_RS05335	COG0330	HflC and HflK could
HN018_RS05355	COG5487	UPF0391 membrane protein
HN018_RS05375	COG1691	(AIR) carboxylase
HN018_RS05385	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HN018_RS05390	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HN018_RS05400	COG0656	L-ascorbic acid biosynthetic process
HN018_RS05415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HN018_RS05420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HN018_RS05425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN018_RS05440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HN018_RS05445	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HN018_RS05465	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HN018_RS05485	COG0714	Associated with various cellular activities
HN018_RS05515	COG2175	clavaminate synthase activity
HN018_RS05525	COG1132	(ABC) transporter
HN018_RS05540	COG2814	Major facilitator Superfamily
HN018_RS05550	COG0300	oxidoreductase activity
HN018_RS05555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HN018_RS05560	COG1295	ribonuclease BN
HN018_RS05570	COG1051	belongs to the nudix hydrolase family
HN018_RS05580	COG0793	Belongs to the peptidase S41A family
HN018_RS05590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HN018_RS05600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN018_RS05615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HN018_RS05630	COG1116	anion transmembrane transporter activity
HN018_RS05635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HN018_RS05650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HN018_RS05655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HN018_RS05660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HN018_RS05670	COG0505	Belongs to the CarA family
HN018_RS05685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HN018_RS05730	COG1285	pathogenesis
HN018_RS05735	COG0625	glutathione transferase activity
HN018_RS05740	COG0360	Binds together with S18 to 16S ribosomal RNA
HN018_RS05745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HN018_RS05750	COG0359	binds to the 23S rRNA
HN018_RS05755	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HN018_RS05760	COG0584	glycerophosphoryl diester phosphodiesterase
HN018_RS05790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HN018_RS05795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HN018_RS05815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HN018_RS05825	COG3217	Mosc domain protein beta barrel domain protein
HN018_RS05825	COG0633	Ferredoxin
HN018_RS05840	COG0009	L-threonylcarbamoyladenylate synthase
HN018_RS05850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HN018_RS05875	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HN018_RS05880	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HN018_RS05885	COG1797	cobyrinic acid a,c-diamide synthase activity
HN018_RS05890	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HN018_RS05970	COG0583	DNA-binding transcription factor activity
HN018_RS05990	COG1492	cobalamin metabolic process
HN018_RS06005	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HN018_RS06015	COG3706	GGDEF domain
HN018_RS06030	COG0463	Glycosyl transferase, family 2
HN018_RS06040	COG0656	L-ascorbic acid biosynthetic process
HN018_RS06065	COG0649	NAD binding
HN018_RS06070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_RS06075	COG1183	phosphatidylcholine synthase activity
HN018_RS06080	COG0688	phosphatidylethanolamine metabolic process
HN018_RS06105	COG1064	alcohol dehydrogenase
HN018_RS06110	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HN018_RS06120	COG4774	siderophore transport
HN018_RS06130	COG1294	oxidase, subunit
HN018_RS06135	COG1271	oxidase subunit
HN018_RS06185	COG1349	DNA-binding transcription factor activity
HN018_RS06190	COG2223	nitrite transmembrane transporter activity
HN018_RS06215	COG0438	transferase activity, transferring glycosyl groups
HN018_RS06235	COG0745	RESPONSE REGULATOR receiver
HN018_RS06240	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HN018_RS06245	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HN018_RS06250	COG2814	Major facilitator Superfamily
HN018_RS06255	COG1566	PFAM secretion protein HlyD family protein
HN018_RS06285	COG1872	DUF167
HN018_RS06290	COG0556	nucleotide-excision repair
HN018_RS06300	COG1942	4-Oxalocrotonate Tautomerase
HN018_RS06310	COG0384	phenazine biosynthesis protein PhzF
HN018_RS06315	COG2017	converts alpha-aldose to the beta-anomer
HN018_RS06330	COG1506	peptidase
HN018_RS06330	COG0823	Involved in the tonB-independent uptake of proteins
HN018_RS06350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HN018_RS06355	COG0109	protoheme IX farnesyltransferase activity
HN018_RS06370	COG0312	modulator of DNA gyrase
HN018_RS06375	COG0612	Peptidase, M16
HN018_RS06400	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HN018_RS06405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HN018_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS06440	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HN018_RS06480	COG0438	transferase activity, transferring glycosyl groups
HN018_RS06480	COG1216	Glycosyl transferase, family 2
HN018_RS06490	COG0321	lipoyl(octanoyl) transferase activity
HN018_RS06525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HN018_RS06530	COG2201	protein-glutamate methylesterase activity
HN018_RS06535	COG0745	RESPONSE REGULATOR receiver
HN018_RS06545	COG2198	Histidine kinase
HN018_RS06545	COG0784	Response regulator, receiver
HN018_RS06545	COG0643	Histidine kinase
HN018_RS06555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HN018_RS06570	COG1040	competence protein
HN018_RS06575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HN018_RS06610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HN018_RS06615	COG0124	histidyl-tRNA synthetase
HN018_RS06620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HN018_RS06640	COG2890	protein-(glutamine-N5) methyltransferase activity
HN018_RS06660	COG0582	viral genome integration into host DNA
HN018_RS06745	COG3750	Belongs to the UPF0335 family
HN018_RS06795	COG4974	Belongs to the 'phage' integrase family
HN018_RS06830	COG4626	Terminase
HN018_RS06830	COG1802	Transcriptional regulator
HN018_RS06835	COG4695	Portal protein
HN018_RS07035	COG1253	flavin adenine dinucleotide binding
HN018_RS07045	COG2135	peptidase activity
HN018_RS07065	COG0473	3-isopropylmalate dehydrogenase activity
HN018_RS07070	COG0006	proline dipeptidase activity
HN018_RS07085	COG2264	protein methyltransferase activity
HN018_RS07090	COG0210	DNA helicase
HN018_RS07105	COG3791	Glutathione-dependent formaldehyde-activating
HN018_RS07125	COG0489	protein tyrosine kinase activity
HN018_RS07145	COG2003	Belongs to the UPF0758 family
HN018_RS07150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HN018_RS07155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HN018_RS07180	COG0254	rRNA binding
HN018_RS07190	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HN018_RS07195	COG1970	mechanosensitive ion channel activity
HN018_RS07210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HN018_RS07215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HN018_RS07220	COG0673	inositol 2-dehydrogenase activity
HN018_RS07230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HN018_RS07255	COG2144	transferase activity, transferring acyl groups
HN018_RS07260	COG0438	transferase activity, transferring glycosyl groups
HN018_RS07270	COG2072	flavoprotein involved in K transport
HN018_RS07285	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HN018_RS07290	COG1640	4-alpha-glucanotransferase
HN018_RS07295	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HN018_RS07305	COG0366	Alpha amylase catalytic
HN018_RS07310	COG0784	Response regulator, receiver
HN018_RS07335	COG4988	ABC transporter
HN018_RS07340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HN018_RS07355	COG0667	Aldo Keto reductase
HN018_RS07380	COG3842	ATPase activity
HN018_RS07385	COG3842	ATPase activity
HN018_RS07390	COG1175	transmembrane transport
HN018_RS07395	COG0395	ABC-type sugar transport system, permease component
HN018_RS07410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HN018_RS07435	COG2205	protein histidine kinase activity
HN018_RS07440	COG0745	RESPONSE REGULATOR receiver
HN018_RS07460	COG1129	ABC transporter
HN018_RS07465	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS07470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HN018_RS07475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN018_RS07480	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HN018_RS07520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HN018_RS07535	COG0525	valine-tRNA ligase activity
HN018_RS07540	COG0129	dihydroxy-acid dehydratase activity
HN018_RS07550	COG3511	phospholipase C
HN018_RS07570	COG2080	2 iron, 2 sulfur cluster binding
HN018_RS07575	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HN018_RS07580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HN018_RS07590	COG0542	response to heat
HN018_RS07600	COG0501	Belongs to the peptidase M48B family
HN018_RS07620	COG0129	dihydroxy-acid dehydratase activity
HN018_RS07630	COG1129	ABC transporter
HN018_RS07650	COG0800	Aldolase
HN018_RS07655	COG3734	2-keto-3-deoxy-galactonokinase
HN018_RS07660	COG2186	Transcriptional regulator
HN018_RS07675	COG0662	Cupin 2, conserved barrel domain protein
HN018_RS07685	COG0438	transferase activity, transferring glycosyl groups
HN018_RS07690	COG1132	(ABC) transporter
HN018_RS07695	COG1802	Transcriptional regulator
HN018_RS07700	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HN018_RS07710	COG0850	regulation of cytokinetic process
HN018_RS07720	COG2081	HI0933 family
HN018_RS07735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_RS07755	COG2116	formate transmembrane transporter activity
HN018_RS07795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HN018_RS07800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HN018_RS07820	COG0446	pyridine nucleotide-disulphide oxidoreductase
HN018_RS07840	COG0752	glycyl-tRNA synthetase alpha subunit
HN018_RS07845	COG1832	CoA-binding protein
HN018_RS07865	COG4251	negative regulation of phosphorylation
HN018_RS07870	COG0784	Response regulator, receiver
HN018_RS07875	COG4191	Histidine kinase
HN018_RS07875	COG0784	Response regulator, receiver
HN018_RS07885	COG0655	NAD(P)H dehydrogenase (quinone) activity
HN018_RS07890	COG3920	Histidine kinase
HN018_RS07890	COG2202	Pas domain
HN018_RS07900	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HN018_RS07910	COG3387	PFAM Glycoside hydrolase 15-related
HN018_RS07925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HN018_RS07960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HN018_RS07960	COG2885	chlorophyll binding
HN018_RS07965	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HN018_RS07975	COG4974	Belongs to the 'phage' integrase family
HN018_RS07980	COG0825	malonyl-CoA metabolic process
HN018_RS07995	COG1546	Belongs to the CinA family
HN018_RS07995	COG1058	Belongs to the CinA family
HN018_RS08000	COG3386	PFAM SMP-30 Gluconolaconase
HN018_RS08010	COG0667	Aldo Keto reductase
HN018_RS08015	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS08045	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HN018_RS08050	COG2205	protein histidine kinase activity
HN018_RS08055	COG0745	RESPONSE REGULATOR receiver
HN018_RS08060	COG2814	Major facilitator Superfamily
HN018_RS08065	COG1335	isochorismatase
HN018_RS08075	COG2169	Transcriptional regulator
HN018_RS08075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HN018_RS08085	COG1420	regulation of RNA biosynthetic process
HN018_RS08090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HN018_RS08095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HN018_RS08105	COG1185	polyribonucleotide nucleotidyltransferase activity
HN018_RS08110	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HN018_RS08115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HN018_RS08120	COG0494	nUDIX hydrolase
HN018_RS08130	COG1714	RDD family
HN018_RS08135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HN018_RS08140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HN018_RS08145	COG0653	protein targeting
HN018_RS08150	COG0217	transcriptional regulatory protein
HN018_RS08155	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HN018_RS08170	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS08180	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS08185	COG0583	DNA-binding transcription factor activity
HN018_RS08200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HN018_RS08215	COG0596	Alpha beta hydrolase
HN018_RS08230	COG0632	four-way junction helicase activity
HN018_RS08235	COG2255	four-way junction helicase activity
HN018_RS08240	COG0824	Thioesterase
HN018_RS08250	COG0848	biopolymer transport protein
HN018_RS08260	COG0823	Involved in the tonB-independent uptake of proteins
HN018_RS08265	COG2885	chlorophyll binding
HN018_RS08275	COG0037	tRNA processing
HN018_RS08285	COG1902	pentaerythritol trinitrate reductase activity
HN018_RS08295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HN018_RS08300	COG0352	thiamine-phosphate diphosphorylase activity
HN018_RS08300	COG0351	phosphomethylpyrimidine kinase
HN018_RS08310	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HN018_RS08315	COG0450	alkyl hydroperoxide reductase
HN018_RS08325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HN018_RS08350	COG0483	inositol monophosphate 1-phosphatase activity
HN018_RS08355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HN018_RS08380	COG0352	thiamine-phosphate diphosphorylase activity
HN018_RS08405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HN018_RS08410	COG1692	metallophosphoesterase
HN018_RS08430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HN018_RS08435	COG0025	NhaP-type Na H and K H
HN018_RS08450	COG1309	transcriptional regulator
HN018_RS08470	COG1063	alcohol dehydrogenase
HN018_RS08475	COG3284	Transcriptional regulator
HN018_RS08510	COG0596	Alpha beta hydrolase
HN018_RS08530	COG2244	polysaccharide biosynthetic process
HN018_RS08535	COG2942	2-epimerase
HN018_RS08545	COG1216	Glycosyl transferase, family 2
HN018_RS08565	COG0347	Belongs to the P(II) protein family
HN018_RS08570	COG0436	Aminotransferase
HN018_RS08580	COG0746	molybdenum cofactor guanylyltransferase activity
HN018_RS08590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HN018_RS08595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HN018_RS08600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HN018_RS08610	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HN018_RS08615	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HN018_RS08625	COG0740	serine-type endopeptidase activity
HN018_RS08635	COG0436	Aminotransferase
HN018_RS08645	COG1494	fructose-1,6-bisphosphatase
HN018_RS08650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HN018_RS08675	COG1609	Transcriptional regulator
HN018_RS08680	COG0673	inositol 2-dehydrogenase activity
HN018_RS08695	COG1175	transmembrane transport
HN018_RS08700	COG3833	ABC-type maltose transport systems, permease component
HN018_RS08710	COG0673	inositol 2-dehydrogenase activity
HN018_RS08725	COG0438	transferase activity, transferring glycosyl groups
HN018_RS08780	COG1278	Cold shock
HN018_RS08790	COG1272	protein, Hemolysin III
HN018_RS08805	COG1278	Cold shock
HN018_RS08825	COG3300	MHYT domain
HN018_RS08825	COG5001	Diguanylate cyclase
HN018_RS08835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HN018_RS08840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HN018_RS08845	COG0463	Glycosyl transferase, family 2
HN018_RS08885	COG4771	TonB-dependent receptor
HN018_RS08890	COG1231	oxidoreductase activity
HN018_RS08910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HN018_RS08920	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS08925	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS08945	COG2308	Evidence 4 Homologs of previously reported genes of
HN018_RS09045	COG0531	amino acid
HN018_RS09065	COG1116	anion transmembrane transporter activity
HN018_RS09075	COG0756	dUTP diphosphatase activity
HN018_RS09080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HN018_RS09085	COG2226	methyltransferase
HN018_RS09090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HN018_RS09095	COG0268	Binds directly to 16S ribosomal RNA
HN018_RS09100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HN018_RS09110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HN018_RS09120	COG0697	spore germination
HN018_RS09145	COG0210	DNA helicase
HN018_RS09150	COG1546	Belongs to the CinA family
HN018_RS09150	COG1058	Belongs to the CinA family
HN018_RS09155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HN018_RS09160	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS09165	COG1129	ABC transporter
HN018_RS09170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS09175	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS09190	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS09215	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HN018_RS09220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HN018_RS09220	COG0551	DNA topoisomerase type I activity
HN018_RS09240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HN018_RS09245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HN018_RS09250	COG0604	alcohol dehydrogenase
HN018_RS09250	COG3321	synthase
HN018_RS09250	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS09295	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS09310	COG0363	glucosamine-6-phosphate deaminase activity
HN018_RS09335	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS09340	COG3142	Participates in the control of copper homeostasis
HN018_RS09345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN018_RS09395	COG1595	DNA-templated transcription, initiation
HN018_RS09405	COG1309	transcriptional regulator
HN018_RS09410	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS09425	COG1024	Enoyl-CoA hydratase
HN018_RS09435	COG0183	Belongs to the thiolase family
HN018_RS09440	COG0477	Major facilitator Superfamily
HN018_RS09460	COG0705	Rhomboid family
HN018_RS09470	COG1940	carbohydrate kinase activity
HN018_RS09520	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HN018_RS09550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN018_RS09550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HN018_RS09580	COG0322	excinuclease ABC activity
HN018_RS09585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HN018_RS09590	COG1763	Mo-molybdopterin cofactor biosynthetic process
HN018_RS09600	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HN018_RS09605	COG0314	molybdopterin synthase activity
HN018_RS09615	COG0156	8-amino-7-oxononanoate synthase activity
HN018_RS09625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HN018_RS09625	COG4106	trans-aconitate 2-methyltransferase activity
HN018_RS09630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HN018_RS09635	COG0303	'Molybdopterin
HN018_RS09640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HN018_RS09655	COG0148	phosphopyruvate hydratase activity
HN018_RS09665	COG2272	Belongs to the type-B carboxylesterase lipase family
HN018_RS09675	COG0243	molybdopterin cofactor binding
HN018_RS09680	COG3665	Urea carboxylase-associated protein
HN018_RS09690	COG0545	Peptidyl-prolyl cis-trans isomerase
HN018_RS09700	COG0504	CTP synthase activity
HN018_RS09715	COG0149	triose-phosphate isomerase activity
HN018_RS09725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HN018_RS09735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HN018_RS09740	COG0134	indole-3-glycerol-phosphate synthase activity
HN018_RS09745	COG0315	cyclic pyranopterin monophosphate synthase activity
HN018_RS09750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HN018_RS09755	COG0022	dehydrogenase e1 component
HN018_RS09755	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_RS09760	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_RS09765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HN018_RS09770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HN018_RS09775	COG2867	negative regulation of translational initiation
HN018_RS09790	COG1058	Belongs to the CinA family
HN018_RS09790	COG1546	Belongs to the CinA family
HN018_RS09795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HN018_RS09805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HN018_RS09810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HN018_RS09815	COG0443	Heat shock 70 kDa protein
HN018_RS09820	COG1573	uracil-dna glycosylase
HN018_RS09830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HN018_RS09835	COG0745	RESPONSE REGULATOR receiver
HN018_RS09845	COG1758	RNA polymerase activity
HN018_RS09855	COG0736	holo-[acyl-carrier-protein] synthase activity
HN018_RS09860	COG0681	Belongs to the peptidase S26 family
HN018_RS09865	COG0571	ribonuclease III activity
HN018_RS09875	COG0528	UMP kinase activity
HN018_RS09880	COG0233	cytoplasmic translational termination
HN018_RS09885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HN018_RS09895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HN018_RS09900	COG0750	zinc metalloprotease
HN018_RS09905	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HN018_RS09915	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN018_RS09920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HN018_RS09925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN018_RS09935	COG0346	lactoylglutathione lyase activity
HN018_RS09945	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HN018_RS09950	COG0594	ribonuclease P activity
HN018_RS09960	COG0706	membrane insertase activity
HN018_RS09965	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HN018_RS09970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HN018_RS09980	COG3706	GGDEF domain
HN018_RS09985	COG2171	N-acyltransferase activity
HN018_RS09990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HN018_RS10000	COG0101	tRNA pseudouridine synthase activity
HN018_RS10005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HN018_RS10010	COG0242	peptide deformylase activity
HN018_RS10025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HN018_RS10030	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HN018_RS10035	COG1137	ATPase activity
HN018_RS10085	COG0306	phosphate transporter
HN018_RS10095	COG1742	UPF0060 membrane protein
HN018_RS10100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HN018_RS10105	COG2186	Transcriptional regulator
HN018_RS10110	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS10115	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS10120	COG1129	ABC transporter
HN018_RS10125	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS10135	COG0708	Exodeoxyribonuclease III
HN018_RS10140	COG0316	Belongs to the HesB IscA family
HN018_RS10145	COG0018	arginyl-trna synthetase
HN018_RS10160	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HN018_RS10165	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HN018_RS10170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HN018_RS10175	COG0805	protein transport
HN018_RS10180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HN018_RS10185	COG0438	transferase activity, transferring glycosyl groups
HN018_RS10185	COG1216	Glycosyl transferase, family 2
HN018_RS10205	COG1862	Preprotein translocase
HN018_RS10220	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS10245	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HN018_RS10250	COG0629	single-stranded DNA binding
HN018_RS10255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HN018_RS10260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HN018_RS10285	COG0450	alkyl hydroperoxide reductase
HN018_RS10300	COG3453	Protein conserved in bacteria
HN018_RS10300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN018_RS10335	COG0424	maF-like protein
HN018_RS10340	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HN018_RS10345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HN018_RS10350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HN018_RS10355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HN018_RS10360	COG0717	Belongs to the dCTP deaminase family
HN018_RS10380	COG1538	Outer membrane efflux protein
HN018_RS10420	COG1609	Transcriptional regulator
HN018_RS10445	COG1063	alcohol dehydrogenase
HN018_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS10455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HN018_RS10460	COG0517	IMP dehydrogenase activity
HN018_RS10460	COG0617	tRNA 3'-terminal CCA addition
HN018_RS10460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HN018_RS10465	COG1007	ATP synthesis coupled electron transport
HN018_RS10480	COG0713	ATP synthesis coupled electron transport
HN018_RS10485	COG0839	Belongs to the complex I subunit 6 family
HN018_RS10490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_RS10495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HN018_RS10500	COG1034	ATP synthesis coupled electron transport
HN018_RS10515	COG0649	NAD binding
HN018_RS10515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_RS10520	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_RS10525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_RS10555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HN018_RS10560	COG0564	pseudouridine synthase activity
HN018_RS10570	COG1254	Belongs to the acylphosphatase family
HN018_RS10585	COG0596	Alpha beta hydrolase
HN018_RS10590	COG0583	DNA-binding transcription factor activity
HN018_RS10595	COG0584	glycerophosphoryl diester phosphodiesterase
HN018_RS10610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HN018_RS10610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HN018_RS10635	COG2204	response regulator
HN018_RS10640	COG1923	regulation of RNA biosynthetic process
HN018_RS10645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HN018_RS10650	COG3956	TIGRFAM MazG family protein
HN018_RS10655	COG2801	Transposase and inactivated derivatives
HN018_RS10665	COG2719	SpoVR family
HN018_RS10670	COG2718	Belongs to the UPF0229 family
HN018_RS10675	COG2766	serine protein kinase
HN018_RS10680	COG0321	lipoyl(octanoyl) transferase activity
HN018_RS10680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HN018_RS10685	COG0084	hydrolase, TatD family'
HN018_RS10700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HN018_RS10705	COG1686	Belongs to the peptidase S11 family
HN018_RS10715	COG2951	lytic endotransglycosylase activity
HN018_RS10745	COG1968	undecaprenyl-diphosphatase activity
HN018_RS10865	COG0305	Participates in initiation and elongation during chromosome replication
HN018_RS10900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HN018_RS10905	COG0154	amidase activity
HN018_RS10910	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HN018_RS10915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HN018_RS10940	COG0326	Molecular chaperone. Has ATPase activity
HN018_RS10975	COG0513	Belongs to the DEAD box helicase family
HN018_RS10990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HN018_RS11000	COG0531	amino acid
HN018_RS11005	COG0113	porphobilinogen synthase activity
HN018_RS11010	COG2366	antibiotic biosynthetic process
HN018_RS11015	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HN018_RS11020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HN018_RS11025	COG2271	Major facilitator Superfamily
HN018_RS11030	COG2084	Dehydrogenase
HN018_RS11035	COG0174	glutamine synthetase
HN018_RS11045	COG1381	Involved in DNA repair and RecF pathway recombination
HN018_RS11050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HN018_RS11055	COG0052	Belongs to the universal ribosomal protein uS2 family
HN018_RS11065	COG0300	oxidoreductase activity
HN018_RS11080	COG1136	(ABC) transporter
HN018_RS11090	COG0442	prolyl-tRNA aminoacylation
HN018_RS11100	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HN018_RS11110	COG1007	ATP synthesis coupled electron transport
HN018_RS11120	COG0713	ATP synthesis coupled electron transport
HN018_RS11130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_RS11135	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HN018_RS11140	COG1034	ATP synthesis coupled electron transport
HN018_RS11155	COG0649	NAD binding
HN018_RS11160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_RS11165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_RS11170	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HN018_RS11195	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HN018_RS11200	COG0740	serine-type endopeptidase activity
HN018_RS11205	COG0544	peptidyl-prolyl cis-trans isomerase activity
HN018_RS11215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HN018_RS11215	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HN018_RS11225	COG3387	PFAM Glycoside hydrolase 15-related
HN018_RS11230	COG0513	Belongs to the DEAD box helicase family
HN018_RS11240	COG3214	Protein conserved in bacteria
HN018_RS11250	COG2151	metal-sulfur cluster biosynthetic enzyme
HN018_RS11260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HN018_RS11265	COG0719	Fe-S assembly protein
HN018_RS11270	COG0396	ATPase activity
HN018_RS11275	COG0719	Fe-S assembly protein
HN018_RS11285	COG2733	membrane
HN018_RS11295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN018_RS11305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HN018_RS11310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HN018_RS11320	COG5265	(ABC) transporter
HN018_RS11335	COG1486	melibiose metabolic process
HN018_RS11350	COG0395	ABC-type sugar transport system, permease component
HN018_RS11355	COG1794	racemase activity, acting on amino acids and derivatives
HN018_RS11360	COG4771	TonB-dependent receptor
HN018_RS11365	COG2814	Major facilitator Superfamily
HN018_RS11400	COG0628	permease
HN018_RS11415	COG0776	regulation of translation
HN018_RS11420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HN018_RS11425	COG0416	fatty acid biosynthetic process
HN018_RS11430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HN018_RS11445	COG2205	protein histidine kinase activity
HN018_RS11450	COG0745	RESPONSE REGULATOR receiver
HN018_RS11455	COG1846	Transcriptional regulator
HN018_RS11470	COG0242	peptide deformylase activity
HN018_RS11475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HN018_RS11485	COG0473	3-isopropylmalate dehydrogenase activity
HN018_RS11490	COG0066	3-isopropylmalate dehydratase activity
HN018_RS11495	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HN018_RS11500	COG0335	large ribosomal subunit rRNA binding
HN018_RS11505	COG0336	Belongs to the RNA methyltransferase TrmD family
HN018_RS11510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HN018_RS11515	COG0228	four-way junction DNA binding
HN018_RS11525	COG3158	transport of potassium into the cell
HN018_RS11535	COG1160	GTP binding
HN018_RS11570	COG2814	Major facilitator Superfamily
HN018_RS11580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HN018_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS11590	COG2814	Major facilitator Superfamily
HN018_RS11600	COG3180	Ammonia monooxygenase
HN018_RS11605	COG1335	isochorismatase
HN018_RS11610	COG1309	transcriptional regulator
HN018_RS11620	COG0438	transferase activity, transferring glycosyl groups
HN018_RS11635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HN018_RS11640	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN018_RS11660	COG1309	transcriptional regulator
HN018_RS11715	COG0679	Auxin Efflux Carrier
HN018_RS11725	COG0840	transmembrane signaling receptor activity
HN018_RS11730	COG0025	NhaP-type Na H and K H
HN018_RS11750	COG2022	thiamine diphosphate biosynthetic process
HN018_RS11770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HN018_RS11775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HN018_RS11780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HN018_RS11790	COG5001	Diguanylate cyclase
HN018_RS11790	COG3300	MHYT domain
HN018_RS11795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HN018_RS11835	COG0577	efflux transmembrane transporter activity
HN018_RS11835	COG1136	(ABC) transporter
HN018_RS11910	COG3501	Rhs element vgr protein
HN018_RS11915	COG0515	serine threonine protein kinase
HN018_RS11930	COG0500	methyltransferase
HN018_RS11990	COG0670	Belongs to the BI1 family
HN018_RS11995	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HN018_RS12005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HN018_RS12010	COG1573	uracil-dna glycosylase
HN018_RS12020	COG0601	transmembrane transport
HN018_RS12055	COG1309	transcriptional regulator
HN018_RS12070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HN018_RS12070	COG2080	2 iron, 2 sulfur cluster binding
HN018_RS12075	COG3224	Antibiotic biosynthesis monooxygenase
HN018_RS12080	COG0402	S-adenosylhomocysteine deaminase activity
HN018_RS12095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HN018_RS12105	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS12135	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HN018_RS12140	COG1199	ATP-dependent helicase activity
HN018_RS12145	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HN018_RS12150	COG1278	Cold shock
HN018_RS12155	COG0459	protein refolding
HN018_RS12160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HN018_RS12165	COG5425	PFAM Usg family protein
HN018_RS12190	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HN018_RS12195	COG2857	Cytochrome c1
HN018_RS12195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HN018_RS12225	COG2382	esterase
HN018_RS12255	COG3046	protein related to deoxyribodipyrimidine photolyase
HN018_RS12275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HN018_RS12280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN018_RS12290	COG3655	Transcriptional regulator
HN018_RS12320	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HN018_RS12330	COG0181	hydroxymethylbilane synthase activity
HN018_RS12335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HN018_RS12340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HN018_RS12345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HN018_RS12385	COG0493	'glutamate synthase
HN018_RS12390	COG0546	phosphoglycolate phosphatase activity
HN018_RS12400	COG3300	MHYT domain
HN018_RS12400	COG5001	Diguanylate cyclase
HN018_RS12415	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS12430	COG3162	membrane
HN018_RS12435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HN018_RS12445	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS12450	COG1129	ABC transporter
HN018_RS12455	COG1609	Transcriptional regulator
HN018_RS12460	COG3300	MHYT domain
HN018_RS12460	COG5001	Diguanylate cyclase
HN018_RS12465	COG2130	NADP-dependent
HN018_RS12470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HN018_RS12475	COG1309	transcriptional regulator
HN018_RS12495	COG2706	6-phosphogluconolactonase activity
HN018_RS12505	COG1845	cytochrome c oxidase, subunit III
HN018_RS12510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HN018_RS12515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HN018_RS12530	COG2814	Major facilitator Superfamily
HN018_RS12540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HN018_RS12555	COG0784	Response regulator, receiver
HN018_RS12555	COG4191	Histidine kinase
HN018_RS12560	COG0823	Involved in the tonB-independent uptake of proteins
HN018_RS12560	COG1506	peptidase
HN018_RS12560	COG4946	Tricorn protease homolog
HN018_RS12580	COG0386	Belongs to the glutathione peroxidase family
HN018_RS12600	COG0076	glutamate decarboxylase activity
HN018_RS12605	COG0596	Alpha beta hydrolase
HN018_RS12615	COG1505	serine-type exopeptidase activity
HN018_RS12620	COG0671	phosphoesterase, PA-phosphatase related
HN018_RS12640	COG0673	inositol 2-dehydrogenase activity
HN018_RS12650	COG0436	Aminotransferase
HN018_RS12670	COG2095	MarC family integral membrane protein
HN018_RS12675	COG4993	Dehydrogenase
HN018_RS12690	COG3710	Transcriptional regulator
HN018_RS12700	COG4251	negative regulation of phosphorylation
HN018_RS12700	COG5001	Diguanylate cyclase
HN018_RS12700	COG2203	Gaf domain
HN018_RS12700	COG3706	GGDEF domain
HN018_RS12710	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HN018_RS12715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HN018_RS12725	COG0564	pseudouridine synthase activity
HN018_RS12750	COG0628	permease
HN018_RS12755	COG0604	alcohol dehydrogenase
HN018_RS12755	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS12755	COG3321	synthase
HN018_RS12760	COG0156	8-amino-7-oxononanoate synthase activity
HN018_RS12765	COG0300	oxidoreductase activity
HN018_RS12775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HN018_RS12780	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HN018_RS12800	COG0175	sulfate reduction
HN018_RS12815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN018_RS12820	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HN018_RS12825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HN018_RS12855	COG0484	heat shock protein binding
HN018_RS12860	COG0506	proline dehydrogenase activity
HN018_RS12860	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HN018_RS12860	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HN018_RS12875	COG1201	RNA secondary structure unwinding
HN018_RS12885	COG0415	Belongs to the DNA photolyase family
HN018_RS12890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HN018_RS12895	COG1605	Chorismate mutase
HN018_RS12895	COG0287	Prephenate dehydrogenase
HN018_RS12920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HN018_RS12925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HN018_RS12945	COG2226	methyltransferase
HN018_RS12965	COG0142	geranyltranstransferase activity
HN018_RS12985	COG5002	protein histidine kinase activity
HN018_RS12985	COG5001	Diguanylate cyclase
HN018_RS13000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HN018_RS13010	COG0842	Transport permease protein
HN018_RS13015	COG1131	(ABC) transporter
HN018_RS13020	COG0129	dihydroxy-acid dehydratase activity
HN018_RS13030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN018_RS13055	COG5001	Diguanylate cyclase
HN018_RS13070	COG1309	transcriptional regulator
HN018_RS13165	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS13205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HN018_RS13210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HN018_RS13215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HN018_RS13255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HN018_RS13260	COG1960	acyl-CoA dehydrogenase activity
HN018_RS13280	COG1522	sequence-specific DNA binding
HN018_RS13295	COG2814	Major facilitator Superfamily
HN018_RS13310	COG4771	TonB-dependent receptor
HN018_RS13320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HN018_RS13330	COG4948	Mandelate Racemase Muconate Lactonizing
HN018_RS13335	COG3104	oligopeptide transport
HN018_RS13355	COG2271	Major facilitator Superfamily
HN018_RS13360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_RS13370	COG2186	Transcriptional regulator
HN018_RS13380	COG2271	Major facilitator Superfamily
HN018_RS13390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HN018_RS13405	COG3750	Belongs to the UPF0335 family
HN018_RS13410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HN018_RS13430	COG3875	lactate racemase activity
HN018_RS13440	COG0667	Aldo Keto reductase
HN018_RS13445	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS13465	COG2084	Dehydrogenase
HN018_RS13475	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HN018_RS13480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HN018_RS13485	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HN018_RS13490	COG0215	cysteine-tRNA ligase activity
HN018_RS13500	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HN018_RS13515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HN018_RS13520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HN018_RS13535	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HN018_RS13550	COG1937	Protein conserved in bacteria
HN018_RS13560	COG1596	polysaccharide export
HN018_RS13595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HN018_RS13610	COG1215	transferase activity, transferring glycosyl groups
HN018_RS13615	COG0438	transferase activity, transferring glycosyl groups
HN018_RS13635	COG0659	secondary active sulfate transmembrane transporter activity
HN018_RS13640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HN018_RS13645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HN018_RS13655	COG3008	intermembrane lipid transfer
HN018_RS13655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HN018_RS13685	COG0459	protein refolding
HN018_RS13725	COG0583	DNA-binding transcription factor activity
HN018_RS13730	COG2814	Major facilitator Superfamily
HN018_RS13740	COG0667	Aldo Keto reductase
HN018_RS13745	COG1349	DNA-binding transcription factor activity
HN018_RS13755	COG1129	ABC transporter
HN018_RS13760	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS13765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_RS13770	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
HN018_RS13800	COG3395	kinase activity
HN018_RS13805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HN018_RS13820	COG1959	2 iron, 2 sulfur cluster binding
HN018_RS13830	COG2070	2-Nitropropane dioxygenase
HN018_RS13840	COG2096	Adenosyltransferase
HN018_RS13865	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HN018_RS13885	COG0583	DNA-binding transcription factor activity
HN018_RS13890	COG1902	pentaerythritol trinitrate reductase activity
HN018_RS13925	COG3547	Transposase (IS116 IS110 IS902 family)
HN018_RS13935	COG2814	Major facilitator Superfamily
HN018_RS13940	COG1309	transcriptional regulator
HN018_RS13945	COG3118	belongs to the thioredoxin family
HN018_RS13960	COG0625	glutathione transferase activity
HN018_RS13990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HN018_RS13990	COG2080	2 iron, 2 sulfur cluster binding
HN018_RS14005	COG0723	plastoquinol--plastocyanin reductase activity
HN018_RS14015	COG2001	Belongs to the MraZ family
HN018_RS14020	COG0275	rRNA processing
HN018_RS14035	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HN018_RS14040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HN018_RS14045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HN018_RS14050	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HN018_RS14060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HN018_RS14065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HN018_RS14070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HN018_RS14075	COG1181	Belongs to the D-alanine--D-alanine ligase family
HN018_RS14080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HN018_RS14085	COG0849	cell division
HN018_RS14115	COG0559	Belongs to the binding-protein-dependent transport system permease family
HN018_RS14135	COG0402	S-adenosylhomocysteine deaminase activity
HN018_RS14145	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HN018_RS14150	COG0497	DNA recombination
HN018_RS14155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HN018_RS14170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HN018_RS14175	COG0237	dephospho-CoA kinase activity
HN018_RS14180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HN018_RS14200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HN018_RS14205	COG0165	Argininosuccinate lyase
HN018_RS14240	COG0019	diaminopimelate decarboxylase activity
HN018_RS14255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_RS14260	COG0477	Major facilitator Superfamily
HN018_RS14285	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS14295	COG1902	pentaerythritol trinitrate reductase activity
HN018_RS14315	COG0248	Ppx GppA phosphatase
HN018_RS14320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HN018_RS14345	COG0405	Gamma-glutamyltransferase
HN018_RS14350	COG0784	Response regulator, receiver
HN018_RS14350	COG4191	Histidine kinase
HN018_RS14355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HN018_RS14360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HN018_RS14365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HN018_RS14385	COG0105	UTP biosynthetic process
HN018_RS14390	COG0488	(ABC) transporter
HN018_RS14395	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS14405	COG3537	Alpha-1,2-mannosidase
HN018_RS14415	COG1957	nucleoside hydrolase
HN018_RS14430	COG0251	oxidation-reduction process
HN018_RS14440	COG0175	sulfate reduction
HN018_RS14455	COG0662	Cupin 2, conserved barrel domain protein
HN018_RS14455	COG2207	Transcriptional regulator
HN018_RS14465	COG4221	oxidoreductase activity
HN018_RS14485	COG1086	Polysaccharide biosynthesis protein
HN018_RS14490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HN018_RS14505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HN018_RS14550	COG2115	Belongs to the xylose isomerase family
HN018_RS14555	COG1609	Transcriptional regulator
HN018_RS14565	COG4213	ABC transporter substrate-binding protein
HN018_RS14575	COG4214	carbohydrate transport
HN018_RS14580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HN018_RS14600	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HN018_RS14615	COG0745	RESPONSE REGULATOR receiver
HN018_RS14640	COG4786	Flagellar basal body rod
HN018_RS14645	COG4786	Flagellar basal body rod
HN018_RS14655	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HN018_RS14670	COG1706	bacterial-type flagellum-dependent cell motility
HN018_RS14690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HN018_RS14730	COG2205	protein histidine kinase activity
HN018_RS14735	COG2271	Major facilitator Superfamily
HN018_RS14740	COG1238	metal cluster binding
HN018_RS14750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HN018_RS14765	COG0741	lytic transglycosylase activity
HN018_RS14780	COG1253	flavin adenine dinucleotide binding
HN018_RS14790	COG2372	response to copper ion
HN018_RS14800	COG0019	diaminopimelate decarboxylase activity
HN018_RS14805	COG1295	ribonuclease BN
HN018_RS14810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HN018_RS14815	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HN018_RS14825	COG0439	Biotin carboxylase
HN018_RS14835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HN018_RS14845	COG0398	Pfam SNARE associated Golgi protein
HN018_RS14850	COG1612	heme a metabolic process
HN018_RS14855	COG0312	modulator of DNA gyrase
HN018_RS14860	COG2814	Major facilitator Superfamily
HN018_RS14870	COG0667	Aldo Keto reductase
HN018_RS14890	COG1127	ABC transporter
HN018_RS14895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HN018_RS14905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HN018_RS14935	COG0305	Participates in initiation and elongation during chromosome replication
HN018_RS14945	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HN018_RS14945	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HN018_RS14950	COG0194	GDP metabolic process
HN018_RS14965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HN018_RS14990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HN018_RS15015	COG0436	Aminotransferase
HN018_RS15020	COG0405	Gamma-glutamyltransferase
HN018_RS15040	COG2271	Major facilitator Superfamily
HN018_RS15045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_RS15050	COG0156	8-amino-7-oxononanoate synthase activity
HN018_RS15060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HN018_RS15070	COG0126	phosphoglycerate kinase activity
HN018_RS15105	COG0519	Catalyzes the synthesis of GMP from XMP
HN018_RS15110	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS15120	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS15130	COG1312	Catalyzes the dehydration of D-mannonate
HN018_RS15135	COG4106	trans-aconitate 2-methyltransferase activity
HN018_RS15140	COG0552	protein localization to endoplasmic reticulum
HN018_RS15145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HN018_RS15150	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HN018_RS15155	COG0277	FAD linked oxidase domain protein
HN018_RS15165	COG0154	amidase activity
HN018_RS15205	COG2116	formate transmembrane transporter activity
HN018_RS15220	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HN018_RS15225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HN018_RS15235	COG0667	Aldo Keto reductase
HN018_RS15250	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HN018_RS15255	COG0745	RESPONSE REGULATOR receiver
HN018_RS15260	COG0583	DNA-binding transcription factor activity
HN018_RS15270	COG0655	NAD(P)H dehydrogenase (quinone) activity
HN018_RS15310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN018_RS15320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HN018_RS15355	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS15380	COG0490	domain, Protein
HN018_RS15380	COG0471	metal ion transport
HN018_RS15395	COG2204	response regulator
HN018_RS15400	COG2205	protein histidine kinase activity
HN018_RS15410	COG0412	Dienelactone hydrolase
HN018_RS15420	COG3588	fructose-bisphosphate aldolase
HN018_RS15445	COG0246	Mannitol dehydrogenase
HN018_RS15450	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS15460	COG5441	Belongs to the UPF0261 family
HN018_RS15465	COG5564	TIM-barrel signal transduction protein
HN018_RS15485	COG0481	GTPase activity
HN018_RS15500	COG0072	phenylalanine-tRNA ligase activity
HN018_RS15500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HN018_RS15505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HN018_RS15510	COG1129	ABC transporter
HN018_RS15525	COG1609	Transcriptional regulator
HN018_RS15530	COG0366	Alpha amylase catalytic
HN018_RS15535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HN018_RS15540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HN018_RS15560	COG0488	(ABC) transporter
HN018_RS15565	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HN018_RS15575	COG4208	sulfate ABC transporter
HN018_RS15580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HN018_RS15590	COG5383	Protein conserved in bacteria
HN018_RS15595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HN018_RS15605	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS15645	COG2814	Major facilitator Superfamily
HN018_RS15650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HN018_RS15670	COG3511	phospholipase C
HN018_RS15675	COG1793	dna ligase
HN018_RS15715	COG0395	ABC-type sugar transport system, permease component
HN018_RS15720	COG1175	transmembrane transport
HN018_RS15730	COG1609	Transcriptional regulator
HN018_RS15740	COG0784	Response regulator, receiver
HN018_RS15740	COG4191	Histidine kinase
HN018_RS15755	COG0729	surface antigen
HN018_RS15765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HN018_RS15770	COG1702	phosphate starvation-inducible protein PhoH
HN018_RS15775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HN018_RS15785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HN018_RS15810	COG2943	transferase activity, transferring hexosyl groups
HN018_RS15815	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HN018_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS15840	COG1063	alcohol dehydrogenase
HN018_RS15845	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS15855	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS15865	COG0698	ribose 5-phosphate isomerase
HN018_RS15900	COG0489	protein tyrosine kinase activity
HN018_RS15910	COG3237	CsbD-like
HN018_RS15935	COG2261	transglycosylase associated protein
HN018_RS15940	COG0179	Fumarylacetoacetate (FAA) hydrolase
HN018_RS15950	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HN018_RS15980	COG0534	Mate efflux family protein
HN018_RS15985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HN018_RS15990	COG0343	queuine tRNA-ribosyltransferase activity
HN018_RS15995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HN018_RS16005	COG5002	protein histidine kinase activity
HN018_RS16005	COG5001	Diguanylate cyclase
HN018_RS16015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HN018_RS16020	COG3023	N-Acetylmuramoyl-L-alanine amidase
HN018_RS16040	COG2853	Lipoprotein
HN018_RS16055	COG0488	(ABC) transporter
HN018_RS16065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HN018_RS16105	COG1410	methionine synthase
HN018_RS16105	COG0646	methionine synthase
HN018_RS16120	COG0140	phosphoribosyl-ATP diphosphatase activity
HN018_RS16130	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HN018_RS16140	COG2226	methyltransferase
HN018_RS16155	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HN018_RS16165	COG2233	PERMEase
HN018_RS16185	COG0784	Response regulator, receiver
HN018_RS16185	COG2198	Histidine kinase
HN018_RS16185	COG2205	protein histidine kinase activity
HN018_RS16190	COG1024	Enoyl-CoA hydratase
HN018_RS16200	COG0523	cobalamin synthesis protein
HN018_RS16210	COG0438	transferase activity, transferring glycosyl groups
HN018_RS16215	COG0625	glutathione transferase activity
HN018_RS16220	COG0482	sulfurtransferase activity
HN018_RS16225	COG0633	Ferredoxin
HN018_RS16230	COG1104	cysteine desulfurase activity
HN018_RS16240	COG2945	thiolester hydrolase activity
HN018_RS16245	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HN018_RS16250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HN018_RS16255	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS16270	COG1959	2 iron, 2 sulfur cluster binding
HN018_RS16290	COG1064	alcohol dehydrogenase
HN018_RS16300	COG5001	Diguanylate cyclase
HN018_RS16305	COG0673	inositol 2-dehydrogenase activity
HN018_RS16335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HN018_RS16340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HN018_RS16345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN018_RS16355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HN018_RS16370	COG2226	methyltransferase
HN018_RS16385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HN018_RS16400	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HN018_RS16410	COG1914	H( )-stimulated, divalent metal cation uptake system
HN018_RS16415	COG1321	iron dependent repressor
HN018_RS16420	COG4566	intracellular signal transduction
HN018_RS16425	COG0563	adenylate kinase activity
HN018_RS16430	COG4251	negative regulation of phosphorylation
HN018_RS16435	COG3590	peptidase
HN018_RS16445	COG0045	succinate-CoA ligase (ADP-forming) activity
HN018_RS16450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HN018_RS16470	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HN018_RS16475	COG0799	negative regulation of ribosome biogenesis
HN018_RS16480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HN018_RS16485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HN018_RS16490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HN018_RS16505	COG2755	lipolytic protein G-D-S-L family
HN018_RS16505	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HN018_RS16510	COG0012	GTP binding
HN018_RS16515	COG0193	aminoacyl-tRNA hydrolase activity
HN018_RS16520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HN018_RS16525	COG3177	Filamentation induced by cAMP protein fic
HN018_RS16530	COG0406	alpha-ribazole phosphatase activity
HN018_RS16535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HN018_RS16555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HN018_RS16590	COG0776	regulation of translation
HN018_RS16595	COG3754	Rhamnan synthesis protein F
HN018_RS16610	COG0438	transferase activity, transferring glycosyl groups
HN018_RS16610	COG1216	Glycosyl transferase, family 2
HN018_RS16615	COG1088	dTDP-glucose 4,6-dehydratase activity
HN018_RS16620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HN018_RS16625	COG0679	Auxin Efflux Carrier
HN018_RS16635	COG3052	prosthetic group binding
HN018_RS16655	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HN018_RS16665	COG0251	oxidation-reduction process
HN018_RS16670	COG0668	transmembrane transport
HN018_RS16695	COG0531	amino acid
HN018_RS16700	COG1770	oligopeptidase
HN018_RS16710	COG4774	siderophore transport
HN018_RS16745	COG1215	transferase activity, transferring glycosyl groups
HN018_RS16760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HN018_RS16765	COG1032	radical SAM domain protein
HN018_RS16795	COG5487	UPF0391 membrane protein
HN018_RS16800	COG0840	transmembrane signaling receptor activity
HN018_RS16805	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HN018_RS16810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HN018_RS16815	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HN018_RS16820	COG1877	trehalose-phosphatase activity
HN018_RS16845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HN018_RS16860	COG0538	isocitrate dehydrogenase activity
HN018_RS16870	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HN018_RS16875	COG1684	flagellar biosynthetic protein fliR
HN018_RS16880	COG1987	bacterial-type flagellum assembly
HN018_RS16885	COG1677	Flagellar hook-basal body complex protein FliE
HN018_RS16890	COG1558	bacterial-type flagellum-dependent cell motility
HN018_RS16905	COG1338	Plays a role in the flagellum-specific transport system
HN018_RS16920	COG1982	Orn Lys Arg decarboxylase major
HN018_RS16925	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HN018_RS16935	COG0114	fumarate hydratase activity
HN018_RS16955	COG0784	Response regulator, receiver
HN018_RS16955	COG4191	Histidine kinase
HN018_RS16970	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS16975	COG4948	Mandelate Racemase Muconate Lactonizing
HN018_RS16985	COG1063	alcohol dehydrogenase
HN018_RS16990	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS16995	COG1129	ABC transporter
HN018_RS17000	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS17005	COG2186	Transcriptional regulator
HN018_RS17010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_RS17025	COG0778	Nitroreductase
HN018_RS17035	COG0386	Belongs to the glutathione peroxidase family
HN018_RS17045	COG0131	Imidazoleglycerol-phosphate dehydratase
HN018_RS17050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HN018_RS17055	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HN018_RS17060	COG0107	imidazoleglycerol-phosphate synthase activity
HN018_RS17065	COG0140	phosphoribosyl-ATP diphosphatase activity
HN018_RS17080	COG1902	pentaerythritol trinitrate reductase activity
HN018_RS17085	COG3300	MHYT domain
HN018_RS17085	COG5001	Diguanylate cyclase
HN018_RS17110	COG5265	(ABC) transporter
HN018_RS17125	COG0658	competence protein
HN018_RS17125	COG2333	competence protein COMEC
HN018_RS17130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HN018_RS17135	COG0540	Belongs to the ATCase OTCase family
HN018_RS17145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HN018_RS17150	COG0758	DNA mediated transformation
HN018_RS17155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HN018_RS17160	COG0557	exoribonuclease II activity
HN018_RS17165	COG0793	Belongs to the peptidase S41A family
HN018_RS17185	COG0457	Tetratricopeptide repeat
HN018_RS17190	COG4206	TonB-dependent receptor
HN018_RS17195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HN018_RS17195	COG2885	chlorophyll binding
HN018_RS17205	COG1959	2 iron, 2 sulfur cluster binding
HN018_RS17210	COG0450	alkyl hydroperoxide reductase
HN018_RS17215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HN018_RS17230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN018_RS17235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HN018_RS17240	COG0187	DNA topoisomerase II activity
HN018_RS17250	COG2124	cytochrome p450
HN018_RS17270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HN018_RS17280	COG0656	L-ascorbic acid biosynthetic process
HN018_RS17285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HN018_RS17290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HN018_RS17300	COG0196	riboflavin kinase activity
HN018_RS17305	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HN018_RS17310	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HN018_RS17315	COG0235	Class ii aldolase
HN018_RS17320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HN018_RS17335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HN018_RS17340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HN018_RS17365	COG4232	protein-disulfide reductase activity
HN018_RS17370	COG1643	Atp-dependent helicase
HN018_RS17380	COG0745	RESPONSE REGULATOR receiver
HN018_RS17385	COG2205	protein histidine kinase activity
HN018_RS17405	COG0463	Glycosyl transferase, family 2
HN018_RS17415	COG0772	Belongs to the SEDS family
HN018_RS17425	COG0028	Belongs to the TPP enzyme family
HN018_RS17435	COG3768	UPF0283 membrane protein
HN018_RS17440	COG3106	COG3106 Predicted ATPase
HN018_RS17450	COG1472	Belongs to the glycosyl hydrolase 3 family
HN018_RS17455	COG0768	penicillin binding
HN018_RS17490	COG0151	Belongs to the GarS family
HN018_RS17495	COG1570	exodeoxyribonuclease VII activity
HN018_RS17530	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HN018_RS17535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HN018_RS17560	COG0513	Belongs to the DEAD box helicase family
HN018_RS17575	COG1940	carbohydrate kinase activity
HN018_RS17585	COG1722	exodeoxyribonuclease VII activity
HN018_RS17590	COG0142	geranyltranstransferase activity
HN018_RS17595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HN018_RS17600	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HN018_RS17610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HN018_RS17620	COG0246	Mannitol dehydrogenase
HN018_RS17625	COG1070	Carbohydrate kinase
HN018_RS17650	COG2226	methyltransferase
HN018_RS17660	COG0137	argininosuccinate synthase activity
HN018_RS17675	COG1435	thymidine kinase activity
HN018_RS17680	COG0180	Tryptophanyl-tRNA synthetase
HN018_RS17685	COG0432	Pfam Uncharacterised protein family UPF0047
HN018_RS17710	COG0395	ABC-type sugar transport system, permease component
HN018_RS17725	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HN018_RS17730	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HN018_RS17735	COG0243	molybdopterin cofactor binding
HN018_RS17750	COG0778	Nitroreductase
HN018_RS17755	COG1301	dicarboxylic acid transport
HN018_RS17765	COG1129	ABC transporter
HN018_RS17770	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS17775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HN018_RS17780	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HN018_RS17785	COG2080	2 iron, 2 sulfur cluster binding
HN018_RS17790	COG0681	Belongs to the peptidase S26 family
HN018_RS17810	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HN018_RS17815	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HN018_RS17825	COG1595	DNA-templated transcription, initiation
HN018_RS17845	COG1129	ABC transporter
HN018_RS17865	COG3781	membrane
HN018_RS17875	COG2824	Alkylphosphonate utilization operon protein PhnA
HN018_RS17880	COG3706	GGDEF domain
HN018_RS17890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HN018_RS17895	COG0745	RESPONSE REGULATOR receiver
HN018_RS17900	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS17910	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS17915	COG1129	ABC transporter
HN018_RS17925	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS17930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HN018_RS17935	COG3958	Transketolase
HN018_RS17940	COG3959	Transketolase, thiamine diphosphate binding domain
HN018_RS17945	COG4251	negative regulation of phosphorylation
HN018_RS17965	COG4181	ATPase activity
HN018_RS17980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HN018_RS17985	COG1116	anion transmembrane transporter activity
HN018_RS17990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HN018_RS17995	COG0840	transmembrane signaling receptor activity
HN018_RS18010	COG1132	(ABC) transporter
HN018_RS18015	COG0793	Belongs to the peptidase S41A family
HN018_RS18015	COG4946	Tricorn protease homolog
HN018_RS18030	COG2186	Transcriptional regulator
HN018_RS18035	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS18040	COG1129	ABC transporter
HN018_RS18045	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS18050	COG3386	PFAM SMP-30 Gluconolaconase
HN018_RS18055	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS18060	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS18065	COG1129	ABC transporter
HN018_RS18070	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS18080	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HN018_RS18085	COG1454	alcohol dehydrogenase
HN018_RS18095	COG1129	ABC transporter
HN018_RS18100	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS18120	COG1070	Carbohydrate kinase
HN018_RS18140	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS18150	COG3254	rhamnose metabolic process
HN018_RS18155	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS18160	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS18175	COG1349	DNA-binding transcription factor activity
HN018_RS18180	COG3347	Dehydrogenase
HN018_RS18180	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS18185	COG4952	isomerase
HN018_RS18190	COG0247	lactate metabolic process
HN018_RS18195	COG1139	Iron-sulfur cluster binding protein
HN018_RS18210	COG3275	phosphorelay sensor kinase activity
HN018_RS18215	COG3279	Response regulator of the LytR AlgR family
HN018_RS18320	COG0489	protein tyrosine kinase activity
HN018_RS18320	COG3206	protein involved in exopolysaccharide biosynthesis
HN018_RS18330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HN018_RS18335	COG1238	metal cluster binding
HN018_RS18340	COG2197	response regulator
HN018_RS18345	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HN018_RS18385	COG2094	Belongs to the DNA glycosylase MPG family
HN018_RS18400	COG3550	peptidyl-serine autophosphorylation
HN018_RS18410	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS18430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HN018_RS18435	COG2835	tetraacyldisaccharide 4'-kinase activity
HN018_RS18440	COG3153	acetyltransferase
HN018_RS18445	COG3842	ATPase activity
HN018_RS18455	COG1175	transmembrane transport
HN018_RS18465	COG1063	alcohol dehydrogenase
HN018_RS18470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HN018_RS18480	COG0028	Belongs to the TPP enzyme family
HN018_RS18485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HN018_RS18490	COG0560	Phosphoserine phosphatase
HN018_RS18490	COG3830	Belongs to the UPF0237 family
HN018_RS18500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HN018_RS18525	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS18530	COG0179	Fumarylacetoacetate (FAA) hydrolase
HN018_RS18535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HN018_RS18555	COG0702	epimerase
HN018_RS18580	COG0318	PFAM AMP-dependent synthetase and ligase
HN018_RS18590	COG0456	acetyltransferase
HN018_RS18620	COG1597	lipid kinase activity
HN018_RS18630	COG0156	8-amino-7-oxononanoate synthase activity
HN018_RS18655	COG3239	Fatty acid desaturase
HN018_RS18665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HN018_RS18665	COG0519	Catalyzes the synthesis of GMP from XMP
HN018_RS18700	COG1216	Glycosyl transferase, family 2
HN018_RS18700	COG0438	transferase activity, transferring glycosyl groups
HN018_RS18720	COG1956	GAF domain-containing protein
HN018_RS18735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HN018_RS18740	COG1360	Flagellar Motor Protein
HN018_RS18755	COG1522	sequence-specific DNA binding
HN018_RS18760	COG0492	ferredoxin-NADP+ reductase activity
HN018_RS18765	COG0583	DNA-binding transcription factor activity
HN018_RS18785	COG0776	regulation of translation
HN018_RS18790	COG0616	signal peptide processing
HN018_RS18815	COG0494	nUDIX hydrolase
HN018_RS18830	COG1073	alpha beta
HN018_RS18835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN018_RS18850	COG0028	Belongs to the TPP enzyme family
HN018_RS18855	COG0582	viral genome integration into host DNA
HN018_RS18890	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_RS18890	COG0596	Alpha beta hydrolase
HN018_RS18900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN018_RS18900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HN018_RS18905	COG1999	signal sequence binding
HN018_RS18910	COG0747	negative chemotaxis
HN018_RS18920	COG0601	transmembrane transport
HN018_RS18930	COG4608	Belongs to the ABC transporter superfamily
HN018_RS18935	COG1671	Belongs to the UPF0178 family
HN018_RS18945	COG3265	gluconokinase activity
HN018_RS18955	COG0363	glucosamine-6-phosphate deaminase activity
HN018_RS18965	COG0561	phosphatase activity
HN018_RS18970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HN018_RS18975	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HN018_RS18980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HN018_RS19015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HN018_RS19030	COG0583	DNA-binding transcription factor activity
HN018_RS19040	COG1063	alcohol dehydrogenase
HN018_RS19050	COG2351	hydroxyisourate hydrolase activity
HN018_RS19055	COG2072	flavoprotein involved in K transport
HN018_RS19070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HN018_RS19085	COG3038	cytochrome b561
HN018_RS19090	COG3585	molybdate ion transport
HN018_RS19115	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HN018_RS19120	COG4149	molybdate abc transporter
HN018_RS19125	COG0725	ABC transporter, periplasmic molybdate-binding protein
HN018_RS19130	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HN018_RS19145	COG0668	transmembrane transport
HN018_RS19155	COG1696	Membrane protein involved in D-alanine export
HN018_RS19195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HN018_RS19245	COG1196	nuclear chromosome segregation
HN018_RS19245	COG0741	lytic transglycosylase activity
HN018_RS19245	COG0739	heme binding
HN018_RS19255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HN018_RS19255	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HN018_RS19340	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS19400	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS19430	COG1484	DNA-dependent DNA replication
HN018_RS19435	COG4584	PFAM Integrase catalytic
HN018_RS19455	COG3920	Histidine kinase
HN018_RS19460	COG4191	Histidine kinase
HN018_RS19460	COG0784	Response regulator, receiver
HN018_RS19470	COG4372	Transposase
HN018_RS19475	COG4372	Transposase
HN018_RS19480	COG3436	PFAM IS66 Orf2 family protein
HN018_RS19495	COG3436	PFAM IS66 Orf2 family protein
HN018_RS19520	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HN018_RS19610	COG1902	pentaerythritol trinitrate reductase activity
HN018_RS19615	COG0583	DNA-binding transcription factor activity
HN018_RS19640	COG2967	ApaG domain
HN018_RS19650	COG0302	gtp cyclohydrolase
HN018_RS19660	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HN018_RS19685	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HN018_RS19690	COG0521	Mo-molybdopterin cofactor biosynthetic process
HN018_RS19695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HN018_RS19695	COG1648	precorrin-2 dehydrogenase activity
HN018_RS19710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HN018_RS19710	COG2755	lipolytic protein G-D-S-L family
HN018_RS19720	COG2755	lipolytic protein G-D-S-L family
HN018_RS19720	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HN018_RS19735	COG2124	cytochrome p450
HN018_RS19740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HN018_RS19800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HN018_RS19805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HN018_RS19845	COG3275	phosphorelay sensor kinase activity
HN018_RS19850	COG0596	Alpha beta hydrolase
HN018_RS19865	COG2986	histidine ammonia-lyase
HN018_RS19870	COG2423	ornithine cyclodeaminase activity
HN018_RS19875	COG2271	Major facilitator Superfamily
HN018_RS19890	COG0402	S-adenosylhomocysteine deaminase activity
HN018_RS19895	COG0513	Belongs to the DEAD box helicase family
HN018_RS19915	COG0745	RESPONSE REGULATOR receiver
HN018_RS19925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HN018_RS19930	COG0581	inorganic phosphate transmembrane transporter activity
HN018_RS19940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HN018_RS19955	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS19960	COG1129	ABC transporter
HN018_RS19995	COG1737	Transcriptional regulator
HN018_RS20000	COG0673	inositol 2-dehydrogenase activity
HN018_RS20015	COG5001	Diguanylate cyclase
HN018_RS20015	COG3300	MHYT domain
HN018_RS20020	COG0328	RNA-DNA hybrid ribonuclease activity
HN018_RS20025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HN018_RS20030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HN018_RS20040	COG0509	glycine decarboxylation via glycine cleavage system
HN018_RS20055	COG2814	Major facilitator Superfamily
HN018_RS20060	COG1297	OPT oligopeptide transporter protein
HN018_RS20065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HN018_RS20070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HN018_RS20080	COG1505	serine-type exopeptidase activity
HN018_RS20135	COG0438	transferase activity, transferring glycosyl groups
HN018_RS20150	COG2226	methyltransferase
HN018_RS20165	COG0463	Glycosyl transferase, family 2
HN018_RS20170	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HN018_RS20175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HN018_RS20180	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HN018_RS20185	COG0356	it plays a direct role in the translocation of protons across the membrane
HN018_RS20195	COG2837	iron assimilation
HN018_RS20210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HN018_RS20210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HN018_RS20215	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HN018_RS20220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HN018_RS20230	COG2814	Major facilitator Superfamily
HN018_RS20235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HN018_RS20240	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS20245	COG4970	Tfp pilus assembly protein FimT
HN018_RS20250	COG1216	Glycosyl transferase, family 2
HN018_RS20260	COG0612	Peptidase, M16
HN018_RS20265	COG2165	general secretion pathway protein
HN018_RS20275	COG3166	PFAM Fimbrial assembly family protein
HN018_RS20315	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS20335	COG1309	transcriptional regulator
HN018_RS20345	COG1012	belongs to the aldehyde dehydrogenase family
HN018_RS20350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_RS20360	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS20365	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS20370	COG1129	ABC transporter
HN018_RS20380	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HN018_RS20390	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS20395	COG1063	alcohol dehydrogenase
HN018_RS20415	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS20435	COG2195	Cleaves the N-terminal amino acid of tripeptides
HN018_RS20445	COG3239	Fatty acid desaturase
HN018_RS20460	COG3718	enzyme involved in inositol metabolism
HN018_RS20465	COG3962	Belongs to the TPP enzyme family
HN018_RS20470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_RS20475	COG1459	type II secretion system
HN018_RS20480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HN018_RS20510	COG0438	transferase activity, transferring glycosyl groups
HN018_RS20530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HN018_RS20535	COG1464	Belongs to the NlpA lipoprotein family
HN018_RS20540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HN018_RS20545	COG2011	ABC-type metal ion transport system permease component
HN018_RS20560	COG0776	regulation of translation
HN018_RS20565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HN018_RS20570	COG2309	aminopeptidase activity
HN018_RS20575	COG0438	transferase activity, transferring glycosyl groups
HN018_RS20590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HN018_RS20590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HN018_RS20605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HN018_RS20610	COG3158	transport of potassium into the cell
HN018_RS20615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HN018_RS20635	COG0741	lytic transglycosylase activity
HN018_RS20645	COG1902	pentaerythritol trinitrate reductase activity
HN018_RS20660	COG0495	leucyl-tRNA aminoacylation
HN018_RS20685	COG3387	PFAM Glycoside hydrolase 15-related
HN018_RS20695	COG0437	4 iron, 4 sulfur cluster binding
HN018_RS20720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HN018_RS20725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HN018_RS20750	COG3045	CreA protein
HN018_RS20780	COG0280	phosphate acetyltransferase
HN018_RS20780	COG0281	malic enzyme
HN018_RS20785	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HN018_RS20815	COG1842	Phage shock protein A
HN018_RS20820	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HN018_RS20825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN018_RS20830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HN018_RS20860	COG2721	sulfolactate sulfo-lyase activity
HN018_RS20865	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS20870	COG1129	ABC transporter
HN018_RS20875	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS20880	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS20885	COG4221	oxidoreductase activity
HN018_RS20890	COG3104	oligopeptide transport
HN018_RS20900	COG0564	pseudouridine synthase activity
HN018_RS20905	COG2223	nitrite transmembrane transporter activity
HN018_RS20925	COG1129	ABC transporter
HN018_RS20930	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS20935	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS20950	COG1070	Carbohydrate kinase
HN018_RS20955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HN018_RS20960	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_RS20960	COG0022	dehydrogenase e1 component
HN018_RS20965	COG0508	dehydrogenase complex catalyzes the overall conversion of
HN018_RS20965	COG0596	Alpha beta hydrolase
HN018_RS20975	COG1129	ABC transporter
HN018_RS20980	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS20985	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS20990	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS21000	COG0742	ribosomal rna small subunit methyltransferase
HN018_RS21005	COG1187	pseudouridine synthase activity
HN018_RS21010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HN018_RS21015	COG0590	tRNA wobble adenosine to inosine editing
HN018_RS21015	COG0037	tRNA processing
HN018_RS21030	COG2814	Major facilitator Superfamily
HN018_RS21080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HN018_RS21085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HN018_RS21090	COG1116	anion transmembrane transporter activity
HN018_RS21095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HN018_RS21105	COG1215	transferase activity, transferring glycosyl groups
HN018_RS21110	COG1091	dTDP-4-dehydrorhamnose reductase activity
HN018_RS21145	COG0259	pyridoxamine-phosphate oxidase activity
HN018_RS21150	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HN018_RS21155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HN018_RS21160	COG2121	Domain of unknown function (DUF374)
HN018_RS21165	COG1519	Transferase
HN018_RS21170	COG1663	tetraacyldisaccharide 4'-kinase activity
HN018_RS21185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HN018_RS21190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HN018_RS21195	COG3237	CsbD-like
HN018_RS21210	COG0138	bifunctional purine biosynthesis protein purh
HN018_RS21215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HN018_RS21220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HN018_RS21220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HN018_RS21225	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HN018_RS21225	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HN018_RS21240	COG1216	Glycosyl transferase, family 2
HN018_RS21240	COG0438	transferase activity, transferring glycosyl groups
HN018_RS21250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HN018_RS21255	COG1121	(ABC) transporter
HN018_RS21265	COG0735	belongs to the Fur family
HN018_RS21280	COG0285	dihydrofolate synthase activity
HN018_RS21285	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HN018_RS21290	COG0159	tryptophan synthase activity
HN018_RS21295	COG0133	tryptophan synthase activity
HN018_RS21300	COG0598	Magnesium transport protein CorA
HN018_RS21310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HN018_RS21320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HN018_RS21325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HN018_RS21330	COG0445	tRNA wobble uridine modification
HN018_RS21335	COG0357	Ribosomal RNA small subunit methyltransferase G
HN018_RS21360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HN018_RS21365	COG0424	maF-like protein
HN018_RS21380	COG0586	Pfam SNARE associated Golgi protein
HN018_RS21385	COG0590	tRNA wobble adenosine to inosine editing
HN018_RS21410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HN018_RS21420	COG1566	PFAM secretion protein HlyD family protein
HN018_RS21430	COG1289	transmembrane transporter activity
HN018_RS21445	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS21470	COG0024	Methionine aminopeptidase
HN018_RS21505	COG0583	DNA-binding transcription factor activity
HN018_RS21515	COG0300	oxidoreductase activity
HN018_RS21530	COG1484	DNA-dependent DNA replication
HN018_RS21550	COG0587	DNA-directed DNA polymerase activity
HN018_RS21575	COG0287	Prephenate dehydrogenase
HN018_RS21585	COG1850	ribulose-bisphosphate carboxylase activity
HN018_RS21595	COG0149	triose-phosphate isomerase activity
HN018_RS21610	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS21620	COG1129	ABC transporter
HN018_RS21625	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS21630	COG0673	inositol 2-dehydrogenase activity
HN018_RS21640	COG2186	Transcriptional regulator
HN018_RS21645	COG0667	Aldo Keto reductase
HN018_RS21655	COG1116	anion transmembrane transporter activity
HN018_RS21690	COG1960	acyl-CoA dehydrogenase activity
HN018_RS21695	COG1250	3-hydroxyacyl-CoA dehydrogenase
HN018_RS21695	COG1024	Enoyl-CoA hydratase
HN018_RS21700	COG0183	Belongs to the thiolase family
HN018_RS21710	COG0318	PFAM AMP-dependent synthetase and ligase
HN018_RS21715	COG0789	Transcriptional regulator
HN018_RS21720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HN018_RS21750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HN018_RS21765	COG2223	nitrite transmembrane transporter activity
HN018_RS21770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HN018_RS21780	COG1024	Enoyl-CoA hydratase
HN018_RS21810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HN018_RS21815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HN018_RS21820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HN018_RS21830	COG0243	molybdopterin cofactor binding
HN018_RS21845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HN018_RS21880	COG4372	Transposase
HN018_RS21890	COG4372	Transposase
HN018_RS21910	COG0753	catalase activity
HN018_RS21925	COG5001	Diguanylate cyclase
HN018_RS21940	COG2198	Histidine kinase
HN018_RS21940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HN018_RS21940	COG0784	Response regulator, receiver
HN018_RS21940	COG2205	protein histidine kinase activity
HN018_RS21965	COG4372	Transposase
HN018_RS21970	COG3436	PFAM IS66 Orf2 family protein
HN018_RS21975	COG2963	transposase activity
HN018_RS21995	COG2433	Pfam Transposase IS66
HN018_RS22000	COG3436	PFAM IS66 Orf2 family protein
HN018_RS22005	COG2963	transposase activity
HN018_RS22055	COG0745	RESPONSE REGULATOR receiver
HN018_RS22085	COG1484	DNA-dependent DNA replication
HN018_RS22090	COG4584	PFAM Integrase catalytic
HN018_RS22210	COG3547	Transposase (IS116 IS110 IS902 family)
HN018_RS22220	COG3547	Transposase (IS116 IS110 IS902 family)
HN018_RS22225	COG3387	PFAM Glycoside hydrolase 15-related
HN018_RS22235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HN018_RS22240	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HN018_RS22280	COG1566	PFAM secretion protein HlyD family protein
HN018_RS22305	COG0789	Transcriptional regulator
HN018_RS22315	COG4372	Transposase
HN018_RS22320	COG3436	PFAM IS66 Orf2 family protein
HN018_RS22335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HN018_RS22370	COG1902	pentaerythritol trinitrate reductase activity
HN018_RS22375	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS22385	COG0583	DNA-binding transcription factor activity
HN018_RS22390	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS22410	COG3436	PFAM IS66 Orf2 family protein
HN018_RS22415	COG4372	Transposase
HN018_RS22440	COG2801	Transposase and inactivated derivatives
HN018_RS22460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HN018_RS22475	COG0776	regulation of translation
HN018_RS22495	COG3706	GGDEF domain
HN018_RS22500	COG2198	Histidine kinase
HN018_RS22500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HN018_RS22500	COG2205	protein histidine kinase activity
HN018_RS22500	COG0784	Response regulator, receiver
HN018_RS22545	COG2201	protein-glutamate methylesterase activity
HN018_RS22550	COG2202	Pas domain
HN018_RS22550	COG3920	Histidine kinase
HN018_RS22555	COG0784	Response regulator, receiver
HN018_RS22555	COG4191	Histidine kinase
HN018_RS22580	COG4584	PFAM Integrase catalytic
HN018_RS22585	COG1484	DNA-dependent DNA replication
HN018_RS22590	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HN018_RS22595	COG4251	negative regulation of phosphorylation
HN018_RS22630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_RS22640	COG0601	transmembrane transport
HN018_RS22645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HN018_RS22660	COG0673	inositol 2-dehydrogenase activity
HN018_RS22670	COG0444	Belongs to the ABC transporter superfamily
HN018_RS22680	COG4206	TonB-dependent receptor
HN018_RS22700	COG0587	DNA-directed DNA polymerase activity
HN018_RS22735	COG0582	viral genome integration into host DNA
HN018_RS22790	COG3436	PFAM IS66 Orf2 family protein
HN018_RS22830	COG1802	Transcriptional regulator
HN018_RS22870	COG2072	flavoprotein involved in K transport
HN018_RS22885	COG0765	amino acid transport
HN018_RS22890	COG4597	amino acid ABC transporter
HN018_RS22900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HN018_RS22915	COG1126	abc transporter atp-binding protein
HN018_RS22920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HN018_RS22935	COG2188	Transcriptional regulator
HN018_RS22945	COG0473	3-isopropylmalate dehydrogenase activity
HN018_RS22960	COG1012	belongs to the aldehyde dehydrogenase family
HN018_RS22985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HN018_RS22990	COG0583	DNA-binding transcription factor activity
HN018_RS22995	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HN018_RS23000	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS23010	COG2140	Oxalate decarboxylase
HN018_RS23030	COG2706	6-phosphogluconolactonase activity
HN018_RS23035	COG2271	Major facilitator Superfamily
HN018_RS23050	COG1012	belongs to the aldehyde dehydrogenase family
HN018_RS23060	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS23075	COG4372	Transposase
HN018_RS23080	COG3436	PFAM IS66 Orf2 family protein
HN018_RS23155	COG1484	DNA-dependent DNA replication
HN018_RS23160	COG4584	PFAM Integrase catalytic
HN018_RS23160	COG2390	Transcriptional regulator
HN018_RS23175	COG3395	kinase activity
HN018_RS23195	COG0473	3-isopropylmalate dehydrogenase activity
HN018_RS23200	COG2706	6-phosphogluconolactonase activity
HN018_RS23510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HN018_RS23515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HN018_RS23540	COG2135	peptidase activity
HN018_RS23565	COG0629	single-stranded DNA binding
HN018_RS23600	COG1475	DNA binding
HN018_RS23610	COG4974	Belongs to the 'phage' integrase family
HN018_RS23615	COG4974	Belongs to the 'phage' integrase family
HN018_RS23620	COG4974	Belongs to the 'phage' integrase family
HN018_RS23705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HN018_RS23735	COG0210	DNA helicase
HN018_RS23805	COG3436	PFAM IS66 Orf2 family protein
HN018_RS23810	COG2433	Pfam Transposase IS66
HN018_RS23825	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HN018_RS23825	COG3264	Mechanosensitive ion channel
HN018_RS23830	COG4372	Transposase
HN018_RS23835	COG3436	PFAM IS66 Orf2 family protein
HN018_RS23850	COG5001	Diguanylate cyclase
HN018_RS23855	COG5001	Diguanylate cyclase
HN018_RS23885	COG5487	UPF0391 membrane protein
HN018_RS23995	COG1295	ribonuclease BN
HN018_RS24025	COG2323	membrane
HN018_RS24045	COG3387	PFAM Glycoside hydrolase 15-related
HN018_RS24055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HN018_RS24060	COG1845	cytochrome c oxidase, subunit III
HN018_RS24095	COG1192	Involved in chromosome partitioning
HN018_RS24135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HN018_RS24230	COG0629	single-stranded DNA binding
HN018_RS24275	COG4584	PFAM Integrase catalytic
HN018_RS24280	COG1484	DNA-dependent DNA replication
HN018_RS24335	COG0800	Aldolase
HN018_RS24340	COG2140	Oxalate decarboxylase
HN018_RS24345	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS24350	COG1129	ABC transporter
HN018_RS24355	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS24365	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS24380	COG0583	DNA-binding transcription factor activity
HN018_RS24385	COG0604	alcohol dehydrogenase
HN018_RS24385	COG3321	synthase
HN018_RS24395	COG2514	catechol 2,3-dioxygenase activity
HN018_RS24405	COG2207	Transcriptional regulator
HN018_RS24410	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS24430	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS24480	COG1970	mechanosensitive ion channel activity
HN018_RS24485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HN018_RS24515	COG1484	DNA-dependent DNA replication
HN018_RS24520	COG4584	PFAM Integrase catalytic
HN018_RS24550	COG0583	DNA-binding transcription factor activity
HN018_RS24560	COG2814	Major facilitator Superfamily
HN018_RS24570	COG2249	NAD(P)H dehydrogenase (quinone) activity
HN018_RS24575	COG1012	belongs to the aldehyde dehydrogenase family
HN018_RS24585	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS24600	COG4221	oxidoreductase activity
HN018_RS24615	COG0477	Major facilitator Superfamily
HN018_RS24630	COG0028	Belongs to the TPP enzyme family
HN018_RS24640	COG4566	intracellular signal transduction
HN018_RS24650	COG0783	Belongs to the Dps family
HN018_RS24670	COG4191	Histidine kinase
HN018_RS24700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HN018_RS24715	COG2433	Pfam Transposase IS66
HN018_RS24720	COG3436	PFAM IS66 Orf2 family protein
HN018_RS24725	COG2963	transposase activity
HN018_RS24735	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS24750	COG3547	Transposase (IS116 IS110 IS902 family)
HN018_RS24760	COG3547	Transposase (IS116 IS110 IS902 family)
HN018_RS24765	COG4584	PFAM Integrase catalytic
HN018_RS24770	COG1484	DNA-dependent DNA replication
HN018_RS24890	COG3706	GGDEF domain
HN018_RS24910	COG0776	regulation of translation
HN018_RS24920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HN018_RS24935	COG4957	zinc ion binding
HN018_RS24950	COG2801	Transposase and inactivated derivatives
HN018_RS25080	COG4221	oxidoreductase activity
HN018_RS25155	COG5001	Diguanylate cyclase
HN018_RS25230	COG1982	Orn Lys Arg decarboxylase major
HN018_RS25245	COG1945	arginine decarboxylase activity
HN018_RS25270	COG0004	ammonium transporteR
HN018_RS25290	COG0586	Pfam SNARE associated Golgi protein
HN018_RS25295	COG0563	adenylate kinase activity
HN018_RS25300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HN018_RS25300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HN018_RS25315	COG1053	succinate dehydrogenase
HN018_RS25320	COG0492	ferredoxin-NADP+ reductase activity
HN018_RS25325	COG0517	IMP dehydrogenase activity
HN018_RS25330	COG0745	RESPONSE REGULATOR receiver
HN018_RS25335	COG0784	Response regulator, receiver
HN018_RS25335	COG4191	Histidine kinase
HN018_RS25360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HN018_RS25375	COG1902	pentaerythritol trinitrate reductase activity
HN018_RS25380	COG0443	Heat shock 70 kDa protein
HN018_RS25410	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HN018_RS25430	COG3052	prosthetic group binding
HN018_RS25440	COG0679	Auxin Efflux Carrier
HN018_RS25450	COG1554	hydrolase, family 65, central catalytic
HN018_RS25455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HN018_RS25480	COG0330	HflC and HflK could
HN018_RS25510	COG2326	polyphosphate kinase activity
HN018_RS25545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HN018_RS25550	COG0149	triose-phosphate isomerase activity
HN018_RS25570	COG3459	Glycosyltransferase 36 associated
HN018_RS25605	COG0406	alpha-ribazole phosphatase activity
HN018_RS25610	COG3588	fructose-bisphosphate aldolase
HN018_RS25615	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HN018_RS25620	COG0837	glucose binding
HN018_RS25630	COG0149	triose-phosphate isomerase activity
HN018_RS25650	COG2271	Major facilitator Superfamily
HN018_RS25655	COG3265	gluconokinase activity
HN018_RS25700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HN018_RS25715	COG4372	Transposase
HN018_RS25720	COG3436	PFAM IS66 Orf2 family protein
HN018_RS25735	COG0698	ribose 5-phosphate isomerase
HN018_RS25775	COG1064	alcohol dehydrogenase
HN018_RS25790	COG0628	permease
HN018_RS25845	COG0375	protein maturation
HN018_RS25860	COG3259	Nickel-dependent hydrogenase
HN018_RS25865	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
HN018_RS25875	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HN018_RS25885	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HN018_RS25930	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN018_RS25960	COG1475	DNA binding
HN018_RS25965	COG1192	Involved in chromosome partitioning
HN018_RS25975	COG1484	DNA-dependent DNA replication
HN018_RS26010	COG2894	cell division
HN018_RS26040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HN018_RS26065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HN018_RS26090	COG1392	Phosphate transport regulator
HN018_RS26120	COG3293	Transposase
HN018_RS26125	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS26130	COG1172	Belongs to the binding-protein-dependent transport system permease family
HN018_RS26135	COG1129	ABC transporter
HN018_RS26140	COG1879	ABC-type sugar transport system periplasmic component
HN018_RS26175	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HN018_RS26215	COG4214	carbohydrate transport
HN018_RS26255	COG1484	DNA-dependent DNA replication
HN018_RS26295	COG2205	protein histidine kinase activity
HN018_RS26300	COG0745	RESPONSE REGULATOR receiver
HN018_RS26305	COG2853	Lipoprotein
HN018_RS26315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HN018_RS26330	COG4584	PFAM Integrase catalytic
HN018_RS26330	COG2390	Transcriptional regulator
HN018_RS26370	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS26395	COG3293	Transposase
HN018_RS26420	COG4372	Transposase
HN018_RS26425	COG3436	PFAM IS66 Orf2 family protein
HN018_RS26430	COG2826	transposase and inactivated derivatives, IS30 family
HN018_RS26465	COG4372	Transposase
HN018_RS26470	COG3436	PFAM IS66 Orf2 family protein
HN018_RS26475	COG2963	transposase activity
HN018_RS26480	COG4251	negative regulation of phosphorylation
HN018_RS26485	COG4251	negative regulation of phosphorylation
HN018_RS26495	COG5001	Diguanylate cyclase
HN018_RS26510	COG4584	PFAM Integrase catalytic
HN018_RS26515	COG1484	DNA-dependent DNA replication
HN018_RS26520	COG2801	Transposase and inactivated derivatives
HN018_RS26530	COG4191	Histidine kinase
HN018_RS26530	COG0784	Response regulator, receiver
HN018_RS26545	COG1733	regulation of RNA biosynthetic process
HN018_RS26570	COG0745	RESPONSE REGULATOR receiver
HN018_RS26590	COG4372	Transposase
HN018_RS26595	COG3436	PFAM IS66 Orf2 family protein
HN018_RS26605	COG0025	NhaP-type Na H and K H
HN018_RS26610	COG0025	NhaP-type Na H and K H
HN018_RS26615	COG0025	NhaP-type Na H and K H
HN018_RS26645	COG0477	Major facilitator Superfamily
HN018_RS26650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HN018_RS26655	COG3384	dioxygenase
HN018_RS26660	COG0583	DNA-binding transcription factor activity
HN018_RS26785	COG3436	PFAM IS66 Orf2 family protein
HN018_RS26790	COG2433	Pfam Transposase IS66
HN018_RS26800	COG0745	RESPONSE REGULATOR receiver
HN018_RS26805	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HN018_RS26810	COG0784	Response regulator, receiver
HN018_RS26810	COG2205	protein histidine kinase activity
HN018_RS26815	COG5001	Diguanylate cyclase
HN018_RS26835	COG1566	PFAM secretion protein HlyD family protein
HN018_RS26840	COG2814	Major facilitator Superfamily
HN018_RS26890	COG0784	Response regulator, receiver
HN018_RS26890	COG2205	protein histidine kinase activity
HN018_RS26890	COG2198	Histidine kinase
HN018_RS26890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HN018_RS26915	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HN018_RS26940	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HN018_RS26940	COG3264	Mechanosensitive ion channel
HN018_RS26980	COG3702	type iv secretory pathway
HN018_RS26985	COG3451	type IV secretory pathway VirB4
HN018_RS27005	COG3736	Type IV secretory pathway, component VirB8
HN018_RS27020	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HN018_RS27025	COG3505	Type IV secretory pathway VirD4
HN018_RS27065	COG1505	serine-type exopeptidase activity
HN018_RS27105	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HN018_RS27120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HN018_RS27185	COG3436	PFAM IS66 Orf2 family protein
HN018_RS27190	COG4372	Transposase
HN018_RS27250	COG1522	sequence-specific DNA binding
HN018_RS27260	COG3158	transport of potassium into the cell
HN018_RS27305	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS27335	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HN018_RS27340	COG2205	protein histidine kinase activity
HN018_RS27345	COG0745	RESPONSE REGULATOR receiver
HN018_RS27435	COG1475	DNA binding
HN018_RS27485	COG4584	PFAM Integrase catalytic
HN018_RS27490	COG1484	DNA-dependent DNA replication
HN018_RS27565	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS27575	COG2376	Dihydroxyacetone kinase
HN018_RS27585	COG2390	Transcriptional regulator
HN018_RS27595	COG1454	alcohol dehydrogenase
HN018_RS27615	COG0583	DNA-binding transcription factor activity
HN018_RS27675	COG0776	regulation of translation
HN018_RS27705	COG0583	DNA-binding transcription factor activity
HN018_RS27755	COG5001	Diguanylate cyclase
HN018_RS27755	COG4251	negative regulation of phosphorylation
HN018_RS27755	COG2203	Gaf domain
HN018_RS27755	COG3706	GGDEF domain
HN018_RS27790	COG4214	carbohydrate transport
HN018_RS27830	COG4584	PFAM Integrase catalytic
HN018_RS27835	COG1484	DNA-dependent DNA replication
HN018_RS27845	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS27850	COG1028	Short-chain dehydrogenase reductase Sdr
HN018_RS27875	COG2814	Major facilitator Superfamily
HN018_RS27895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HN018_RS27915	COG2202	Pas domain
HN018_RS27915	COG3920	Histidine kinase
HN018_RS27920	COG2201	protein-glutamate methylesterase activity
HN018_RS28020	COG0028	Belongs to the TPP enzyme family
HN018_RS28070	COG3702	type iv secretory pathway
HN018_RS28075	COG3451	type IV secretory pathway VirB4
HN018_RS28100	COG3736	Type IV secretory pathway, component VirB8
HN018_RS28115	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HN018_RS28120	COG3505	Type IV secretory pathway VirD4
HN018_RS28145	COG2184	nucleotidyltransferase activity
HN018_RS28170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HN018_RS28190	COG1475	DNA binding
HN018_RS28195	COG1192	Involved in chromosome partitioning
HN018_RS28215	COG3586	endonuclease activity
HN018_RS28220	COG4974	Belongs to the 'phage' integrase family
HN018_RS28285	COG1476	TRANSCRIPTIONal
HN018_RS28310	COG2826	transposase and inactivated derivatives, IS30 family