locus-tag	class	description
AWO_RS00010	COG0592	DNA-directed DNA polymerase activity
AWO_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AWO_RS00025	COG0187	DNA topoisomerase II activity
AWO_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWO_RS00035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWO_RS00040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AWO_RS00045	COG3414	Phosphotransferase system galactitol-specific IIB component
AWO_RS00050	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AWO_RS00055	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AWO_RS00065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWO_RS00070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWO_RS00075	COG1120	ATPase activity
AWO_RS00080	COG2226	methyltransferase
AWO_RS00100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWO_RS00110	COG0444	Belongs to the ABC transporter superfamily
AWO_RS00115	COG4608	Belongs to the ABC transporter superfamily
AWO_RS00125	COG2890	protein-(glutamine-N5) methyltransferase activity
AWO_RS00130	COG0601	transmembrane transport
AWO_RS00135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWO_RS00140	COG0747	negative chemotaxis
AWO_RS00145	COG0444	Belongs to the ABC transporter superfamily
AWO_RS00150	COG4608	Belongs to the ABC transporter superfamily
AWO_RS00155	COG0534	Mate efflux family protein
AWO_RS00160	COG2226	methyltransferase
AWO_RS00165	COG1401	restriction endodeoxyribonuclease activity
AWO_RS00170	COG1937	Protein conserved in bacteria
AWO_RS00175	COG3608	succinylglutamate desuccinylase aspartoacylase
AWO_RS00180	COG0583	DNA-binding transcription factor activity
AWO_RS00185	COG0601	transmembrane transport
AWO_RS00190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWO_RS00195	COG0747	negative chemotaxis
AWO_RS00200	COG0444	Belongs to the ABC transporter superfamily
AWO_RS00205	COG4608	Belongs to the ABC transporter superfamily
AWO_RS00210	COG0747	negative chemotaxis
AWO_RS00215	COG0601	transmembrane transport
AWO_RS00220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWO_RS00225	COG0444	Belongs to the ABC transporter superfamily
AWO_RS00230	COG1124	(ABC) transporter
AWO_RS00235	COG2119	membrane
AWO_RS00255	COG2022	thiamine diphosphate biosynthetic process
AWO_RS00260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AWO_RS00265	COG0352	thiamine-phosphate diphosphorylase activity
AWO_RS00270	COG5001	Diguanylate cyclase
AWO_RS00270	COG3300	MHYT domain
AWO_RS00285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWO_RS00285	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWO_RS00320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWO_RS00325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWO_RS00330	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AWO_RS00330	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AWO_RS00340	COG2205	protein histidine kinase activity
AWO_RS00345	COG0745	RESPONSE REGULATOR receiver
AWO_RS00375	COG1393	Belongs to the ArsC family
AWO_RS00425	COG1741	Belongs to the pirin family
AWO_RS00465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWO_RS00470	COG1803	Methylglyoxal synthase
AWO_RS00480	COG4895	conserved protein (DUF2196)
AWO_RS00485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWO_RS00490	COG1120	ATPase activity
AWO_RS00500	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AWO_RS00505	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AWO_RS00510	COG2226	methyltransferase
AWO_RS00530	COG0398	Pfam SNARE associated Golgi protein
AWO_RS00540	COG1737	Transcriptional regulator
AWO_RS00545	COG1063	alcohol dehydrogenase
AWO_RS00550	COG1069	ribulokinase activity
AWO_RS00570	COG1131	(ABC) transporter
AWO_RS00585	COG0745	RESPONSE REGULATOR receiver
AWO_RS00625	COG0745	RESPONSE REGULATOR receiver
AWO_RS00630	COG2205	protein histidine kinase activity
AWO_RS00635	COG1136	(ABC) transporter
AWO_RS00645	COG1959	2 iron, 2 sulfur cluster binding
AWO_RS00650	COG1511	domain protein
AWO_RS00660	COG0517	IMP dehydrogenase activity
AWO_RS00660	COG0516	GMP reductase activity
AWO_RS00670	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AWO_RS00790	COG0484	heat shock protein binding
AWO_RS00800	COG1131	(ABC) transporter
AWO_RS00850	COG5002	protein histidine kinase activity
AWO_RS00855	COG1136	(ABC) transporter
AWO_RS00865	COG1309	transcriptional regulator
AWO_RS00875	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AWO_RS00885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWO_RS00895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWO_RS00900	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWO_RS00905	COG0022	dehydrogenase e1 component
AWO_RS00910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWO_RS00930	COG3706	GGDEF domain
AWO_RS00940	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AWO_RS00950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AWO_RS00990	COG0004	ammonium transporteR
AWO_RS00995	COG0347	Belongs to the P(II) protein family
AWO_RS01020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AWO_RS01030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWO_RS01060	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AWO_RS01100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AWO_RS01105	COG0009	L-threonylcarbamoyladenylate synthase
AWO_RS01110	COG0698	ribose 5-phosphate isomerase
AWO_RS01145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AWO_RS01150	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWO_RS01155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AWO_RS01160	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AWO_RS01165	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AWO_RS01170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AWO_RS01175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AWO_RS01180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWO_RS01185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWO_RS01195	COG1091	dTDP-4-dehydrorhamnose reductase activity
AWO_RS01215	COG1682	transport, permease protein
AWO_RS01220	COG1134	teichoic acid transport
AWO_RS01225	COG0438	transferase activity, transferring glycosyl groups
AWO_RS01225	COG1216	Glycosyl transferase, family 2
AWO_RS01230	COG0860	N-Acetylmuramoyl-L-alanine amidase
AWO_RS01240	COG1216	Glycosyl transferase, family 2
AWO_RS01300	COG1316	TRANSCRIPTIONal
AWO_RS01315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWO_RS01320	COG0765	amino acid transport
AWO_RS01325	COG1126	abc transporter atp-binding protein
AWO_RS01350	COG1136	(ABC) transporter
AWO_RS01355	COG1136	(ABC) transporter
AWO_RS01355	COG0577	efflux transmembrane transporter activity
AWO_RS01365	COG3850	Histidine kinase
AWO_RS01365	COG5002	protein histidine kinase activity
AWO_RS01390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AWO_RS01395	COG1687	branched-chain amino acid
AWO_RS01400	COG1733	regulation of RNA biosynthetic process
AWO_RS01410	COG4978	Transcriptional regulator
AWO_RS01410	COG0789	Transcriptional regulator
AWO_RS01420	COG1720	tRNA m6t6A37 methyltransferase activity
AWO_RS01425	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AWO_RS01430	COG0488	(ABC) transporter
AWO_RS01445	COG4492	Belongs to the UPF0735 family
AWO_RS01460	COG0460	homoserine dehydrogenase
AWO_RS01485	COG0066	3-isopropylmalate dehydratase activity
AWO_RS01490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AWO_RS01495	COG1459	type II secretion system
AWO_RS01505	COG0426	domain, Protein
AWO_RS01510	COG0482	sulfurtransferase activity
AWO_RS01520	COG0745	RESPONSE REGULATOR receiver
AWO_RS01525	COG5002	protein histidine kinase activity
AWO_RS01525	COG3850	Histidine kinase
AWO_RS01545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWO_RS01555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWO_RS01560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AWO_RS01580	COG1131	(ABC) transporter
AWO_RS01585	COG0842	Transport permease protein
AWO_RS01625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWO_RS01630	COG3304	Inner membrane component domain
AWO_RS01640	COG2011	ABC-type metal ion transport system permease component
AWO_RS01645	COG1464	Belongs to the NlpA lipoprotein family
AWO_RS01665	COG0348	domain, Protein
AWO_RS01670	COG0745	RESPONSE REGULATOR receiver
AWO_RS01680	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AWO_RS01690	COG1121	(ABC) transporter
AWO_RS01695	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AWO_RS01720	COG1349	DNA-binding transcription factor activity
AWO_RS01725	COG1105	Belongs to the carbohydrate kinase PfkB family
AWO_RS01730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWO_RS01730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWO_RS01730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AWO_RS01745	COG0076	glutamate decarboxylase activity
AWO_RS01760	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AWO_RS01785	COG0058	SHG alpha-glucan phosphorylase activity
AWO_RS01795	COG0297	glycogen (starch) synthase activity
AWO_RS01810	COG0058	SHG alpha-glucan phosphorylase activity
AWO_RS01815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AWO_RS01830	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AWO_RS01840	COG1307	EDD domain protein, DegV family
AWO_RS01845	COG2183	response to ionizing radiation
AWO_RS01850	COG1329	Transcriptional regulator
AWO_RS01855	COG4956	integral membrane protein (PIN domain superfamily)
AWO_RS01860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWO_RS01860	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
AWO_RS01870	COG1683	Conserved Protein
AWO_RS01875	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWO_RS01885	COG0018	arginyl-trna synthetase
AWO_RS01890	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AWO_RS01905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AWO_RS01910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AWO_RS01915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AWO_RS01920	COG3958	Transketolase
AWO_RS01945	COG1304	FMN binding
AWO_RS01960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWO_RS01980	COG2814	Major facilitator Superfamily
AWO_RS01985	COG0456	acetyltransferase
AWO_RS02025	COG2207	Transcriptional regulator
AWO_RS02030	COG2211	Major facilitator Superfamily
AWO_RS02035	COG0584	glycerophosphoryl diester phosphodiesterase
AWO_RS02040	COG0584	glycerophosphoryl diester phosphodiesterase
AWO_RS02045	COG0242	peptide deformylase activity
AWO_RS02050	COG2378	regulation of single-species biofilm formation
AWO_RS02060	COG1247	-acetyltransferase
AWO_RS02115	COG1592	Rubrerythrin
AWO_RS02120	COG2357	RelA SpoT domain protein
AWO_RS02130	COG3706	GGDEF domain
AWO_RS02165	COG0589	response to stress
AWO_RS02170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AWO_RS02180	COG1027	Aspartate ammonia-lyase
AWO_RS02185	COG0835	chemotaxis
AWO_RS02190	COG1045	serine acetyltransferase
AWO_RS02195	COG2378	regulation of single-species biofilm formation
AWO_RS02210	COG3437	response regulator, receiver
AWO_RS02220	COG0477	Major facilitator Superfamily
AWO_RS02245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AWO_RS02250	COG1328	CTP reductase activity
AWO_RS02250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AWO_RS02315	COG1328	CTP reductase activity
AWO_RS02315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AWO_RS02325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWO_RS02330	COG2270	Major facilitator Superfamily
AWO_RS02340	COG0701	Predicted permease
AWO_RS02350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWO_RS02360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWO_RS02380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWO_RS02385	COG1120	ATPase activity
AWO_RS02435	COG0693	protein deglycase activity
AWO_RS02485	COG1131	(ABC) transporter
AWO_RS02500	COG0733	neurotransmitter:sodium symporter activity
AWO_RS02510	COG1132	(ABC) transporter
AWO_RS02515	COG0747	negative chemotaxis
AWO_RS02525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWO_RS02530	COG4172	Belongs to the ABC transporter superfamily
AWO_RS02555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWO_RS02560	COG1120	ATPase activity
AWO_RS02575	COG3118	belongs to the thioredoxin family
AWO_RS02580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWO_RS02595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWO_RS02600	COG0785	Cytochrome C biogenesis protein
AWO_RS02610	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AWO_RS02620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWO_RS02625	COG0352	thiamine-phosphate diphosphorylase activity
AWO_RS02625	COG0351	phosphomethylpyrimidine kinase
AWO_RS02635	COG1309	transcriptional regulator
AWO_RS02645	COG5012	cobalamin binding
AWO_RS02655	COG1846	Transcriptional regulator
AWO_RS02665	COG0534	Mate efflux family protein
AWO_RS02680	COG3437	response regulator, receiver
AWO_RS02695	COG1595	DNA-templated transcription, initiation
AWO_RS02715	COG1982	Orn Lys Arg decarboxylase major
AWO_RS02720	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AWO_RS02725	COG0010	Belongs to the arginase family
AWO_RS02740	COG2226	methyltransferase
AWO_RS02760	COG5012	cobalamin binding
AWO_RS02770	COG5598	trimethylamine methyltransferase
AWO_RS02775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AWO_RS02780	COG5012	cobalamin binding
AWO_RS02805	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
AWO_RS02815	COG0523	cobalamin synthesis protein
AWO_RS02825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWO_RS02830	COG0569	domain protein
AWO_RS02860	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AWO_RS02865	COG2205	protein histidine kinase activity
AWO_RS02870	COG0745	RESPONSE REGULATOR receiver
AWO_RS02920	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWO_RS02920	COG2199	diguanylate cyclase activity
AWO_RS02930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWO_RS02935	COG0765	amino acid transport
AWO_RS02940	COG1126	abc transporter atp-binding protein
AWO_RS02965	COG3706	GGDEF domain
AWO_RS02975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AWO_RS03010	COG1122	ATPase activity
AWO_RS03015	COG0390	transport system, permease component
AWO_RS03020	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AWO_RS03035	COG1131	(ABC) transporter
AWO_RS03045	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AWO_RS03050	COG2873	o-acetylhomoserine
AWO_RS03055	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AWO_RS03065	COG4129	membrane
AWO_RS03080	COG0512	Glutamine amidotransferase of anthranilate synthase
AWO_RS03090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWO_RS03100	COG0617	tRNA 3'-terminal CCA addition
AWO_RS03100	COG0617	tRNA 3'-terminal CCA addition
AWO_RS03105	COG0084	hydrolase, TatD family'
AWO_RS03130	COG2059	Chromate
AWO_RS03160	COG1013	pyruvate-flavodoxin oxidoreductase activity
AWO_RS03165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AWO_RS03165	COG0674	pyruvate-flavodoxin oxidoreductase activity
AWO_RS03180	COG4106	trans-aconitate 2-methyltransferase activity
AWO_RS03205	COG0210	DNA helicase
AWO_RS03210	COG0583	DNA-binding transcription factor activity
AWO_RS03215	COG1012	belongs to the aldehyde dehydrogenase family
AWO_RS03215	COG1454	alcohol dehydrogenase
AWO_RS03230	COG0148	phosphopyruvate hydratase activity
AWO_RS03235	COG2078	PFAM AMMECR1 domain protein
AWO_RS03235	COG3885	ferrous iron binding
AWO_RS03240	COG1194	a g-specific adenine glycosylase
AWO_RS03250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWO_RS03345	COG3409	Peptidoglycan-binding domain 1 protein
AWO_RS03415	COG0745	RESPONSE REGULATOR receiver
AWO_RS03445	COG0243	molybdopterin cofactor binding
AWO_RS03450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AWO_RS03460	COG3706	GGDEF domain
AWO_RS03460	COG4251	negative regulation of phosphorylation
AWO_RS03460	COG5001	Diguanylate cyclase
AWO_RS03460	COG2203	Gaf domain
AWO_RS03480	COG0583	DNA-binding transcription factor activity
AWO_RS03490	COG0697	spore germination
AWO_RS03495	COG0371	Dehydrogenase
AWO_RS03505	COG4120	Belongs to the binding-protein-dependent transport system permease family
AWO_RS03510	COG1116	anion transmembrane transporter activity
AWO_RS03510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWO_RS03520	COG3585	molybdate ion transport
AWO_RS03550	COG0347	Belongs to the P(II) protein family
AWO_RS03565	COG1785	Belongs to the alkaline phosphatase family
AWO_RS03570	COG1910	domain protein
AWO_RS03585	COG1131	(ABC) transporter
AWO_RS03590	COG4585	Histidine kinase
AWO_RS03610	COG0523	cobalamin synthesis protein
AWO_RS03620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AWO_RS03625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AWO_RS03635	COG0833	amino acid
AWO_RS03640	COG0174	glutamine synthetase
AWO_RS03655	COG0069	glutamate synthase activity
AWO_RS03680	COG0251	oxidation-reduction process
AWO_RS03690	COG1760	l-serine dehydratase
AWO_RS03725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AWO_RS03730	COG2267	carboxylic ester hydrolase activity
AWO_RS03740	COG0493	'glutamate synthase
AWO_RS03745	COG0070	glutamate synthase
AWO_RS03745	COG0069	glutamate synthase activity
AWO_RS03745	COG0067	glutamate synthase
AWO_RS03770	COG0306	phosphate transporter
AWO_RS03780	COG1136	(ABC) transporter
AWO_RS03785	COG0577	efflux transmembrane transporter activity
AWO_RS03790	COG0745	RESPONSE REGULATOR receiver
AWO_RS03795	COG0642	Histidine kinase
AWO_RS03815	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
AWO_RS03820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AWO_RS03825	COG5598	trimethylamine methyltransferase
AWO_RS03830	COG5012	cobalamin binding
AWO_RS03835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AWO_RS03850	COG5002	protein histidine kinase activity
AWO_RS03855	COG0745	RESPONSE REGULATOR receiver
AWO_RS03860	COG0425	Belongs to the sulfur carrier protein TusA family
AWO_RS03860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AWO_RS03870	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AWO_RS03885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AWO_RS03900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWO_RS03905	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWO_RS03910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWO_RS03915	COG0004	ammonium transporteR
AWO_RS03920	COG0347	Belongs to the P(II) protein family
AWO_RS03930	COG0347	Belongs to the P(II) protein family
AWO_RS03940	COG0371	Dehydrogenase
AWO_RS03950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWO_RS03955	COG2390	Transcriptional regulator
AWO_RS03990	COG1433	Dinitrogenase iron-molybdenum cofactor
AWO_RS03990	COG0535	radical SAM domain protein
AWO_RS04010	COG0347	Belongs to the P(II) protein family
AWO_RS04020	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AWO_RS04055	COG0436	Aminotransferase
AWO_RS04060	COG3481	metal-dependent phosphohydrolase, HD sub domain
AWO_RS04070	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AWO_RS04075	COG2116	formate transmembrane transporter activity
AWO_RS04080	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AWO_RS04085	COG5012	cobalamin binding
AWO_RS04090	COG1609	Transcriptional regulator
AWO_RS04105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWO_RS04110	COG0709	Synthesizes selenophosphate from selenide and ATP
AWO_RS04130	COG1921	L-seryl-tRNASec selenium transferase activity
AWO_RS04140	COG0583	DNA-binding transcription factor activity
AWO_RS04145	COG3383	formate dehydrogenase (NAD+) activity
AWO_RS04150	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AWO_RS04150	COG0493	'glutamate synthase
AWO_RS04155	COG3383	formate dehydrogenase (NAD+) activity
AWO_RS04160	COG3383	formate dehydrogenase (NAD+) activity
AWO_RS04165	COG0493	'glutamate synthase
AWO_RS04165	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AWO_RS04170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AWO_RS04175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AWO_RS04175	COG0493	'glutamate synthase
AWO_RS04185	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AWO_RS04190	COG1924	4 iron, 4 sulfur cluster binding
AWO_RS04195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AWO_RS04245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AWO_RS04255	COG0640	Transcriptional regulator
AWO_RS04260	COG2217	Heavy metal translocating P-type atpase
AWO_RS04270	COG0746	molybdenum cofactor guanylyltransferase activity
AWO_RS04275	COG5012	cobalamin binding
AWO_RS04280	COG5012	cobalamin binding
AWO_RS04285	COG2188	Transcriptional regulator
AWO_RS04300	COG0708	Exodeoxyribonuclease III
AWO_RS04305	COG0488	(ABC) transporter
AWO_RS04325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AWO_RS04340	COG0077	Prephenate dehydratase
AWO_RS04340	COG1605	Chorismate mutase
AWO_RS04350	COG0546	phosphoglycolate phosphatase activity
AWO_RS04355	COG4466	Protein conserved in bacteria
AWO_RS04360	COG2235	arginine
AWO_RS04365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AWO_RS04375	COG1129	ABC transporter
AWO_RS04395	COG1132	(ABC) transporter
AWO_RS04395	COG2375	cellular response to nickel ion
AWO_RS04400	COG1132	(ABC) transporter
AWO_RS04405	COG2186	Transcriptional regulator
AWO_RS04410	COG2086	electron transfer activity
AWO_RS04420	COG0277	FAD linked oxidase domain protein
AWO_RS04425	COG1620	l-lactate permease
AWO_RS04430	COG3875	lactate racemase activity
AWO_RS04445	COG0789	Transcriptional regulator
AWO_RS04445	COG4978	Transcriptional regulator
AWO_RS04455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AWO_RS04470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AWO_RS04490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AWO_RS04505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AWO_RS04540	COG0604	alcohol dehydrogenase
AWO_RS04550	COG0698	ribose 5-phosphate isomerase
AWO_RS04555	COG3290	protein histidine kinase activity
AWO_RS04555	COG3829	transcription factor binding
AWO_RS04560	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AWO_RS04565	COG2376	Dihydroxyacetone kinase
AWO_RS04570	COG1461	Dihydroxyacetone kinase
AWO_RS04590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWO_RS04595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWO_RS04600	COG0765	amino acid transport
AWO_RS04610	COG0085	RNA polymerase activity
AWO_RS04615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AWO_RS04620	COG1358	cellular component organization or biogenesis
AWO_RS04625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AWO_RS04630	COG0049	tRNA binding
AWO_RS04635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWO_RS04640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWO_RS04655	COG2211	Major facilitator Superfamily
AWO_RS04660	COG0471	metal ion transport
AWO_RS04695	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AWO_RS04700	COG3404	Formiminotransferase-cyclodeaminase
AWO_RS04705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AWO_RS04710	COG4656	Part of a membrane complex involved in electron transport
AWO_RS04725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWO_RS04730	COG0509	glycine decarboxylation via glycine cleavage system
AWO_RS04745	COG1615	UPF0182 protein
AWO_RS04750	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWO_RS04755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AWO_RS04760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AWO_RS04835	COG2848	UPF0210 protein
AWO_RS04845	COG2001	Belongs to the MraZ family
AWO_RS04860	COG0768	penicillin binding
AWO_RS04865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AWO_RS04875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AWO_RS04880	COG0772	Belongs to the SEDS family
AWO_RS04885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWO_RS04895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AWO_RS04900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AWO_RS04905	COG0494	nUDIX hydrolase
AWO_RS04910	COG1994	Peptidase M50
AWO_RS04915	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AWO_RS04920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AWO_RS04925	COG1187	pseudouridine synthase activity
AWO_RS04945	COG2081	HI0933 family
AWO_RS04950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AWO_RS04955	COG0204	Acyl-transferase
AWO_RS04960	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AWO_RS04960	COG0539	negative regulation of cytoplasmic translation
AWO_RS04965	COG1959	2 iron, 2 sulfur cluster binding
AWO_RS04985	COG0628	permease
AWO_RS04990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWO_RS04995	COG4472	Bacterial protein of unknown function (DUF965)
AWO_RS05000	COG0667	Aldo Keto reductase
AWO_RS05015	COG0735	belongs to the Fur family
AWO_RS05020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AWO_RS05025	COG3679	Belongs to the UPF0342 family
AWO_RS05030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AWO_RS05035	COG4122	O-methyltransferase activity
AWO_RS05040	COG0826	peptidase U32
AWO_RS05055	COG3279	Response regulator of the LytR AlgR family
AWO_RS05105	COG1136	(ABC) transporter
AWO_RS05110	COG2197	response regulator
AWO_RS05130	COG0420	3'-5' exonuclease activity
AWO_RS05135	COG0419	ATPase involved in DNA repair
AWO_RS05145	COG1725	Transcriptional regulator
AWO_RS05170	COG1131	(ABC) transporter
AWO_RS05180	COG1331	Highly conserved protein containing a thioredoxin domain
AWO_RS05205	COG1122	ATPase activity
AWO_RS05210	COG0310	cobalt ion transport
AWO_RS05220	COG4139	cobalamin transport
AWO_RS05225	COG1120	ATPase activity
AWO_RS05250	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AWO_RS05270	COG1131	(ABC) transporter
AWO_RS05295	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AWO_RS05300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AWO_RS05325	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWO_RS05340	COG1342	Belongs to the UPF0251 family
AWO_RS05360	COG2894	cell division
AWO_RS05375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWO_RS05385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWO_RS05390	COG1120	ATPase activity
AWO_RS05400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWO_RS05450	COG1151	hydroxylamine reductase activity
AWO_RS05485	COG1876	peptidase activity
AWO_RS05515	COG0250	Participates in transcription elongation, termination and antitermination
AWO_RS05525	COG0081	regulation of translation
AWO_RS05535	COG0222	ribosome binding
AWO_RS05540	COG0442	prolyl-tRNA aminoacylation
AWO_RS05550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AWO_RS05550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AWO_RS05555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AWO_RS05560	COG1418	mRNA catabolic process
AWO_RS05565	COG0302	gtp cyclohydrolase
AWO_RS05580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AWO_RS05585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AWO_RS05605	COG1854	S-ribosylhomocysteine lyase activity
AWO_RS05615	COG0564	pseudouridine synthase activity
AWO_RS05620	COG0191	fructose-bisphosphate aldolase activity
AWO_RS05655	COG1476	TRANSCRIPTIONal
AWO_RS05770	COG0629	single-stranded DNA binding
AWO_RS05990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWO_RS06055	COG0583	DNA-binding transcription factor activity
AWO_RS06065	COG0493	'glutamate synthase
AWO_RS06070	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AWO_RS06075	COG1053	succinate dehydrogenase
AWO_RS06095	COG0583	DNA-binding transcription factor activity
AWO_RS06100	COG0702	epimerase
AWO_RS06115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AWO_RS06130	COG2814	Major facilitator Superfamily
AWO_RS06150	COG1132	(ABC) transporter
AWO_RS06155	COG1132	(ABC) transporter
AWO_RS06165	COG1196	nuclear chromosome segregation
AWO_RS06185	COG0582	viral genome integration into host DNA
AWO_RS06195	COG0464	growth
AWO_RS06220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWO_RS06225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AWO_RS06250	COG1028	Short-chain dehydrogenase reductase Sdr
AWO_RS06255	COG1309	transcriptional regulator
AWO_RS06270	COG1132	(ABC) transporter
AWO_RS06280	COG4978	Transcriptional regulator
AWO_RS06280	COG0789	Transcriptional regulator
AWO_RS06290	COG1216	Glycosyl transferase, family 2
AWO_RS06300	COG0562	UDP-galactopyranose mutase
AWO_RS06310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AWO_RS06310	COG0493	'glutamate synthase
AWO_RS06320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AWO_RS06325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWO_RS06330	COG0549	Belongs to the carbamate kinase family
AWO_RS06350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWO_RS06360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AWO_RS06365	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWO_RS06370	COG1121	(ABC) transporter
AWO_RS06375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWO_RS06385	COG0667	Aldo Keto reductase
AWO_RS06430	COG3959	Transketolase, thiamine diphosphate binding domain
AWO_RS06435	COG3958	Transketolase
AWO_RS06445	COG0191	fructose-bisphosphate aldolase activity
AWO_RS06450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWO_RS06455	COG0022	dehydrogenase e1 component
AWO_RS06465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWO_RS06470	COG0095	Lipoate-protein ligase
AWO_RS06485	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWO_RS06510	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AWO_RS06515	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AWO_RS06520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AWO_RS06530	COG2188	Transcriptional regulator
AWO_RS06570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWO_RS06575	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AWO_RS06605	COG5002	protein histidine kinase activity
AWO_RS06610	COG0745	RESPONSE REGULATOR receiver
AWO_RS06615	COG0037	tRNA processing
AWO_RS06625	COG0006	proline dipeptidase activity
AWO_RS06630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AWO_RS06645	COG1819	glycosyl
AWO_RS06650	COG0826	peptidase U32
AWO_RS06655	COG1193	negative regulation of DNA recombination
AWO_RS06660	COG0717	Belongs to the dCTP deaminase family
AWO_RS06665	COG1104	cysteine desulfurase activity
AWO_RS06670	COG0301	tRNA thio-modification
AWO_RS06675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AWO_RS06680	COG1739	Uncharacterized protein family UPF0029
AWO_RS06690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AWO_RS06700	COG2255	four-way junction helicase activity
AWO_RS06705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AWO_RS06710	COG0343	queuine tRNA-ribosyltransferase activity
AWO_RS06715	COG1862	Preprotein translocase
AWO_RS06725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AWO_RS06730	COG0254	rRNA binding
AWO_RS06735	COG2890	protein-(glutamine-N5) methyltransferase activity
AWO_RS06760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AWO_RS06765	COG1570	exodeoxyribonuclease VII activity
AWO_RS06770	COG1722	exodeoxyribonuclease VII activity
AWO_RS06780	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AWO_RS06790	COG1438	arginine binding
AWO_RS06795	COG0497	DNA recombination
AWO_RS06800	COG4869	propanediol catabolic process
AWO_RS06805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AWO_RS06810	COG0606	chelatase, subunit chli
AWO_RS06815	COG3944	biosynthesis protein
AWO_RS06820	COG0489	protein tyrosine kinase activity
AWO_RS06845	COG1216	Glycosyl transferase, family 2
AWO_RS06860	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AWO_RS06865	COG0438	transferase activity, transferring glycosyl groups
AWO_RS06875	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AWO_RS06915	COG5002	protein histidine kinase activity
AWO_RS06915	COG5001	Diguanylate cyclase
AWO_RS06970	COG0165	Argininosuccinate lyase
AWO_RS06975	COG0137	argininosuccinate synthase activity
AWO_RS06980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AWO_RS06985	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AWO_RS06990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AWO_RS06995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AWO_RS07000	COG5002	protein histidine kinase activity
AWO_RS07005	COG0745	RESPONSE REGULATOR receiver
AWO_RS07010	COG0745	RESPONSE REGULATOR receiver
AWO_RS07015	COG5002	protein histidine kinase activity
AWO_RS07050	COG0095	Lipoate-protein ligase
AWO_RS07060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWO_RS07080	COG1596	polysaccharide export
AWO_RS07080	COG1555	photosystem II stabilization
AWO_RS07085	COG0517	IMP dehydrogenase activity
AWO_RS07090	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWO_RS07095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWO_RS07095	COG0574	Belongs to the PEP-utilizing enzyme family
AWO_RS07100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWO_RS07115	COG3842	ATPase activity
AWO_RS07135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWO_RS07140	COG4684	Psort location CytoplasmicMembrane, score
AWO_RS07150	COG1966	Carbon starvation protein
AWO_RS07160	COG0590	tRNA wobble adenosine to inosine editing
AWO_RS07170	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AWO_RS07175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWO_RS07180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWO_RS07195	COG0473	3-isopropylmalate dehydrogenase activity
AWO_RS07200	COG0129	dihydroxy-acid dehydratase activity
AWO_RS07205	COG0028	Belongs to the TPP enzyme family
AWO_RS07240	COG3706	GGDEF domain
AWO_RS07255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AWO_RS07260	COG1177	transmembrane transport
AWO_RS07280	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AWO_RS07295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AWO_RS07310	COG0521	Mo-molybdopterin cofactor biosynthetic process
AWO_RS07320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AWO_RS07325	COG0315	cyclic pyranopterin monophosphate synthase activity
AWO_RS07340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AWO_RS07345	COG3326	Membrane
AWO_RS07445	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AWO_RS07460	COG0310	cobalt ion transport
AWO_RS07470	COG1122	ATPase activity
AWO_RS07480	COG3853	Toxic anion resistance protein (TelA)
AWO_RS07485	COG2267	carboxylic ester hydrolase activity
AWO_RS07490	COG1929	Belongs to the glycerate kinase type-1 family
AWO_RS07495	COG3835	regulator
AWO_RS07500	COG4536	flavin adenine dinucleotide binding
AWO_RS07520	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AWO_RS07535	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AWO_RS07540	COG1136	(ABC) transporter
AWO_RS07540	COG0577	efflux transmembrane transporter activity
AWO_RS07570	COG1132	(ABC) transporter
AWO_RS07575	COG1606	tRNA processing
AWO_RS07580	COG3757	hydrolase, family 25
AWO_RS07585	COG2033	superoxide reductase activity
AWO_RS07590	COG1051	belongs to the nudix hydrolase family
AWO_RS07600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AWO_RS07625	COG1141	Ferredoxin
AWO_RS07630	COG2378	regulation of single-species biofilm formation
AWO_RS07635	COG0693	protein deglycase activity
AWO_RS07645	COG0583	DNA-binding transcription factor activity
AWO_RS07655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AWO_RS07660	COG1454	alcohol dehydrogenase
AWO_RS07665	COG0561	phosphatase activity
AWO_RS07670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AWO_RS07675	COG1882	Formate acetyltransferase
AWO_RS07680	COG1882	Formate acetyltransferase
AWO_RS07730	COG4716	Myosin-crossreactive antigen
AWO_RS07740	COG2200	EAL domain
AWO_RS07745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWO_RS07755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWO_RS07790	COG0105	UTP biosynthetic process
AWO_RS07795	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AWO_RS07800	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AWO_RS07805	COG1309	transcriptional regulator
AWO_RS07810	COG0643	Histidine kinase
AWO_RS07810	COG2198	Histidine kinase
AWO_RS07815	COG0835	chemotaxis
AWO_RS07820	COG0840	transmembrane signaling receptor activity
AWO_RS07825	COG2201	protein-glutamate methylesterase activity
AWO_RS07835	COG0784	Response regulator, receiver
AWO_RS07835	COG2205	protein histidine kinase activity
AWO_RS07840	COG0745	RESPONSE REGULATOR receiver
AWO_RS07865	COG2211	Major facilitator Superfamily
AWO_RS07870	COG0646	methionine synthase
AWO_RS07870	COG1410	methionine synthase
AWO_RS07880	COG2211	Major facilitator Superfamily
AWO_RS07905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AWO_RS07910	COG1408	metallophosphoesterase
AWO_RS07920	COG0003	Pfam Anion-transporting ATPase
AWO_RS07930	COG0003	Pfam Anion-transporting ATPase
AWO_RS07945	COG2309	aminopeptidase activity
AWO_RS07965	COG1595	DNA-templated transcription, initiation
AWO_RS07980	COG1522	sequence-specific DNA binding
AWO_RS08005	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AWO_RS08015	COG0840	transmembrane signaling receptor activity
AWO_RS08045	COG0583	DNA-binding transcription factor activity
AWO_RS08060	COG5012	cobalamin binding
AWO_RS08075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWO_RS08080	COG1695	Transcriptional regulator
AWO_RS08090	COG0318	PFAM AMP-dependent synthetase and ligase
AWO_RS08095	COG1960	acyl-CoA dehydrogenase activity
AWO_RS08100	COG2086	electron transfer activity
AWO_RS08105	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AWO_RS08145	COG0789	Transcriptional regulator
AWO_RS08150	COG0596	Alpha beta hydrolase
AWO_RS08155	COG0596	Alpha beta hydrolase
AWO_RS08165	COG1846	Transcriptional regulator
AWO_RS08205	COG0488	(ABC) transporter
AWO_RS08215	COG1695	Transcriptional regulator
AWO_RS08245	COG1131	(ABC) transporter
AWO_RS08270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWO_RS08290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWO_RS08295	COG1131	(ABC) transporter
AWO_RS08305	COG0179	Fumarylacetoacetate (FAA) hydrolase
AWO_RS08315	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AWO_RS08325	COG0284	orotidine-5'-phosphate decarboxylase activity
AWO_RS08330	COG0543	2 iron, 2 sulfur cluster binding
AWO_RS08335	COG0167	dihydroorotate dehydrogenase activity
AWO_RS08340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AWO_RS08345	COG0693	protein deglycase activity
AWO_RS08350	COG0436	Aminotransferase
AWO_RS08365	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWO_RS08400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWO_RS08405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AWO_RS08410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AWO_RS08415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AWO_RS08420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AWO_RS08425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AWO_RS08430	COG0138	bifunctional purine biosynthesis protein purh
AWO_RS08435	COG0151	Belongs to the GarS family
AWO_RS08440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWO_RS08445	COG1472	Belongs to the glycosyl hydrolase 3 family
AWO_RS08450	COG1214	PFAM Peptidase M22, glycoprotease
AWO_RS08455	COG0456	acetyltransferase
AWO_RS08465	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AWO_RS08480	COG5012	cobalamin binding
AWO_RS08490	COG0488	(ABC) transporter
AWO_RS08495	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AWO_RS08500	COG1396	sequence-specific DNA binding
AWO_RS08515	COG2267	carboxylic ester hydrolase activity
AWO_RS08520	COG1234	tRNA 3'-trailer cleavage
AWO_RS08525	COG2333	competence protein COMEC
AWO_RS08525	COG0658	competence protein
AWO_RS08530	COG1466	dna polymerase III delta subunit
AWO_RS08535	COG0268	Binds directly to 16S ribosomal RNA
AWO_RS08540	COG0481	GTPase activity
AWO_RS08550	COG1349	DNA-binding transcription factor activity
AWO_RS08565	COG5012	cobalamin binding
AWO_RS08570	COG2376	Dihydroxyacetone kinase
AWO_RS08585	COG2390	Transcriptional regulator
AWO_RS08595	COG1704	LemA family
AWO_RS08620	COG3457	Alanine racemase
AWO_RS08625	COG0495	leucyl-tRNA aminoacylation
AWO_RS08655	COG1242	4 iron, 4 sulfur cluster binding
AWO_RS08660	COG2357	RelA SpoT domain protein
AWO_RS08665	COG0217	transcriptional regulatory protein
AWO_RS08675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AWO_RS08675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AWO_RS08680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AWO_RS08690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWO_RS08695	COG0557	exoribonuclease II activity
AWO_RS08700	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AWO_RS08715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWO_RS08790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AWO_RS08830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWO_RS08840	COG1131	(ABC) transporter
AWO_RS08845	COG5002	protein histidine kinase activity
AWO_RS08850	COG0745	RESPONSE REGULATOR receiver
AWO_RS08860	COG5002	protein histidine kinase activity
AWO_RS08860	COG3850	Histidine kinase
AWO_RS08865	COG1136	(ABC) transporter
AWO_RS08865	COG0577	efflux transmembrane transporter activity
AWO_RS08900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AWO_RS08905	COG1454	alcohol dehydrogenase
AWO_RS08910	COG1396	sequence-specific DNA binding
AWO_RS08915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AWO_RS08920	COG0531	amino acid
AWO_RS08925	COG1454	alcohol dehydrogenase
AWO_RS08935	COG1396	sequence-specific DNA binding
AWO_RS08950	COG2364	Membrane
AWO_RS08975	COG0840	transmembrane signaling receptor activity
AWO_RS08995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AWO_RS09000	COG1366	Belongs to the anti-sigma-factor antagonist family
AWO_RS09010	COG2172	sigma factor antagonist activity
AWO_RS09020	COG5002	protein histidine kinase activity
AWO_RS09020	COG2205	protein histidine kinase activity
AWO_RS09020	COG0784	Response regulator, receiver
AWO_RS09025	COG3437	response regulator, receiver
AWO_RS09030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWO_RS09035	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AWO_RS09040	COG1687	branched-chain amino acid
AWO_RS09060	COG0436	Aminotransferase
AWO_RS09065	COG0281	malic enzyme
AWO_RS09070	COG0326	Molecular chaperone. Has ATPase activity
AWO_RS09075	COG0488	(ABC) transporter
AWO_RS09095	COG1151	hydroxylamine reductase activity
AWO_RS09115	COG1070	Carbohydrate kinase
AWO_RS09125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWO_RS09160	COG1819	glycosyl
AWO_RS09170	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AWO_RS09205	COG3706	GGDEF domain
AWO_RS09255	COG1160	GTP binding
AWO_RS09265	COG1842	Phage shock protein A
AWO_RS09270	COG1205	dead DEAH box helicase
AWO_RS09270	COG1111	helicase
AWO_RS09275	COG0210	DNA helicase
AWO_RS09295	COG0259	pyridoxamine-phosphate oxidase activity
AWO_RS09330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWO_RS09345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AWO_RS09355	COG3973	AAA domain
AWO_RS09390	COG5012	cobalamin binding
AWO_RS09415	COG2188	Transcriptional regulator
AWO_RS09430	COG1914	H( )-stimulated, divalent metal cation uptake system
AWO_RS09450	COG0583	DNA-binding transcription factor activity
AWO_RS09475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWO_RS09495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AWO_RS09520	COG0071	Belongs to the small heat shock protein (HSP20) family
AWO_RS09530	COG2003	Belongs to the UPF0758 family
AWO_RS09585	COG2198	Histidine kinase
AWO_RS09585	COG0643	Histidine kinase
AWO_RS09600	COG2201	protein-glutamate methylesterase activity
AWO_RS09610	COG0745	RESPONSE REGULATOR receiver
AWO_RS09635	COG2819	hydrolase of the alpha beta superfamily
AWO_RS09640	COG3706	GGDEF domain
AWO_RS09655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AWO_RS09665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AWO_RS09675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWO_RS09680	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AWO_RS09745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWO_RS09755	COG0643	Histidine kinase
AWO_RS09755	COG2198	Histidine kinase
AWO_RS09760	COG0835	chemotaxis
AWO_RS09765	COG0840	transmembrane signaling receptor activity
AWO_RS09775	COG0745	RESPONSE REGULATOR receiver
AWO_RS09825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AWO_RS09830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWO_RS09845	COG0825	malonyl-CoA metabolic process
AWO_RS09850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AWO_RS09855	COG0439	Biotin carboxylase
AWO_RS09865	COG0511	ligase activity, forming carbon-carbon bonds
AWO_RS09870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWO_RS09880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AWO_RS09890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWO_RS09895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWO_RS09920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AWO_RS09925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AWO_RS09930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AWO_RS09935	COG1381	Involved in DNA repair and RecF pathway recombination
AWO_RS09950	COG0346	lactoylglutathione lyase activity
AWO_RS09965	COG0758	DNA mediated transformation
AWO_RS09970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWO_RS09975	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AWO_RS09980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AWO_RS09985	COG0052	Belongs to the universal ribosomal protein uS2 family
AWO_RS09990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AWO_RS09995	COG0528	UMP kinase activity
AWO_RS10000	COG0233	cytoplasmic translational termination
AWO_RS10005	COG0779	Required for maturation of 30S ribosomal subunits
AWO_RS10010	COG0195	Participates in both transcription termination and antitermination
AWO_RS10015	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AWO_RS10020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AWO_RS10025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AWO_RS10035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AWO_RS10040	COG0196	riboflavin kinase activity
AWO_RS10045	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AWO_RS10050	COG1185	polyribonucleotide nucleotidyltransferase activity
AWO_RS10055	COG0756	dUTP diphosphatase activity
AWO_RS10060	COG1674	ftsk spoiiie
AWO_RS10065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AWO_RS10070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AWO_RS10075	COG1058	Belongs to the CinA family
AWO_RS10075	COG1546	Belongs to the CinA family
AWO_RS10080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AWO_RS10085	COG1418	mRNA catabolic process
AWO_RS10090	COG1692	metallophosphoesterase
AWO_RS10095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWO_RS10105	COG0372	Belongs to the citrate synthase family
AWO_RS10110	COG0280	phosphate acetyltransferase
AWO_RS10115	COG1144	Oxidoreductase
AWO_RS10130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AWO_RS10135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWO_RS10140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AWO_RS10150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWO_RS10155	COG0525	valine-tRNA ligase activity
AWO_RS10165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AWO_RS10180	COG1002	Type II restriction enzyme, methylase subunits
AWO_RS10200	COG0653	protein targeting
AWO_RS10215	COG4974	Belongs to the 'phage' integrase family
AWO_RS10220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AWO_RS10240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AWO_RS10245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWO_RS10250	COG0569	domain protein
AWO_RS10255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWO_RS10275	COG1122	ATPase activity
AWO_RS10280	COG4120	Belongs to the binding-protein-dependent transport system permease family
AWO_RS10290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWO_RS10300	COG0012	GTP binding
AWO_RS10305	COG0799	negative regulation of ribosome biogenesis
AWO_RS10310	COG1713	HD superfamily hydrolase involved in NAD metabolism
AWO_RS10315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AWO_RS10325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AWO_RS10330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AWO_RS10335	COG2868	ribosomal protein
AWO_RS10340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AWO_RS10345	COG4509	Sortase family
AWO_RS10350	COG1115	amino acid carrier protein
AWO_RS10370	COG0515	serine threonine protein kinase
AWO_RS10375	COG0577	efflux transmembrane transporter activity
AWO_RS10375	COG1136	(ABC) transporter
AWO_RS10385	COG4399	Belongs to the UPF0754 family
AWO_RS10390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWO_RS10425	COG1846	Transcriptional regulator
AWO_RS10430	COG0534	Mate efflux family protein
AWO_RS10455	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AWO_RS10460	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AWO_RS10485	COG1461	Dihydroxyacetone kinase
AWO_RS10490	COG2376	Dihydroxyacetone kinase
AWO_RS10495	COG0159	tryptophan synthase activity
AWO_RS10500	COG0133	tryptophan synthase activity
AWO_RS10510	COG0134	indole-3-glycerol-phosphate synthase activity
AWO_RS10515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWO_RS10520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWO_RS10520	COG0512	Glutamine amidotransferase of anthranilate synthase
AWO_RS10550	COG2201	protein-glutamate methylesterase activity
AWO_RS10555	COG0513	Belongs to the DEAD box helicase family
AWO_RS10560	COG1278	Cold shock
AWO_RS10575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWO_RS10590	COG0514	ATP-dependent DNA helicase (RecQ)
AWO_RS10605	COG0583	DNA-binding transcription factor activity
AWO_RS10630	COG0424	maF-like protein
AWO_RS10635	COG0275	rRNA processing
AWO_RS10665	COG2190	(PTS) system
AWO_RS10665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWO_RS10665	COG1263	PTS System
AWO_RS10670	COG3711	transcriptional antiterminator
AWO_RS10690	COG1695	Transcriptional regulator
AWO_RS10695	COG2188	Transcriptional regulator
AWO_RS10715	COG1309	transcriptional regulator
AWO_RS10735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWO_RS10740	COG0488	(ABC) transporter
AWO_RS10745	COG0489	protein tyrosine kinase activity
AWO_RS10755	COG1316	TRANSCRIPTIONal
AWO_RS10775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AWO_RS10790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AWO_RS10810	COG0110	maltose O-acetyltransferase activity
AWO_RS10840	COG0438	transferase activity, transferring glycosyl groups
AWO_RS10845	COG0438	transferase activity, transferring glycosyl groups
AWO_RS10870	COG0792	nuclease activity
AWO_RS10875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AWO_RS10880	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AWO_RS10885	COG0681	Belongs to the peptidase S26 family
AWO_RS10890	COG0335	large ribosomal subunit rRNA binding
AWO_RS10895	COG0336	Belongs to the RNA methyltransferase TrmD family
AWO_RS10900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AWO_RS10905	COG1837	Belongs to the UPF0109 family
AWO_RS10910	COG0228	four-way junction DNA binding
AWO_RS10915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AWO_RS10920	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AWO_RS10925	COG0552	protein localization to endoplasmic reticulum
AWO_RS10930	COG1196	nuclear chromosome segregation
AWO_RS10935	COG0571	ribonuclease III activity
AWO_RS10940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWO_RS10945	COG0416	fatty acid biosynthetic process
AWO_RS10950	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AWO_RS10960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AWO_RS10965	COG1323	Belongs to the UPF0348 family
AWO_RS10970	COG2272	Belongs to the type-B carboxylesterase lipase family
AWO_RS11005	COG0237	dephospho-CoA kinase activity
AWO_RS11025	COG1174	glycine betaine transport
AWO_RS11030	COG0517	IMP dehydrogenase activity
AWO_RS11030	COG1125	glycine betaine transport
AWO_RS11050	COG0440	acetolactate synthase activity
AWO_RS11055	COG0028	Belongs to the TPP enzyme family
AWO_RS11065	COG2996	Protein conserved in bacteria
AWO_RS11075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AWO_RS11080	COG0742	ribosomal rna small subunit methyltransferase
AWO_RS11085	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AWO_RS11090	COG1461	Dihydroxyacetone kinase
AWO_RS11095	COG1302	Protein conserved in bacteria
AWO_RS11100	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AWO_RS11105	COG1564	THIamine pyrophosphokinase
AWO_RS11110	COG1162	GTPase activity
AWO_RS11115	COG0515	serine threonine protein kinase
AWO_RS11115	COG2815	serine threonine protein kinase
AWO_RS11120	COG0631	protein serine/threonine phosphatase activity
AWO_RS11125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AWO_RS11130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWO_RS11130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWO_RS11135	COG2738	Putative neutral zinc metallopeptidase
AWO_RS11140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AWO_RS11150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AWO_RS11165	COG1561	YicC-like family, N-terminal region
AWO_RS11170	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AWO_RS11175	COG0564	pseudouridine synthase activity
AWO_RS11190	COG1799	cell septum assembly
AWO_RS11195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AWO_RS11215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AWO_RS11220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AWO_RS11225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWO_RS11230	COG1490	D-aminoacyl-tRNA deacylase activity
AWO_RS11235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWO_RS11245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AWO_RS11245	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AWO_RS11250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWO_RS11255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AWO_RS11260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWO_RS11265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AWO_RS11270	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AWO_RS11275	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AWO_RS11280	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AWO_RS11285	COG0740	serine-type endopeptidase activity
AWO_RS11290	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWO_RS11300	COG0411	ABC transporter
AWO_RS11320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AWO_RS11325	COG0662	Cupin 2, conserved barrel domain protein
AWO_RS11330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWO_RS11335	COG0564	pseudouridine synthase activity
AWO_RS11340	COG2003	Belongs to the UPF0758 family
AWO_RS11345	COG1245	4Fe-4S binding domain
AWO_RS11345	COG2878	Part of a membrane complex involved in electron transport
AWO_RS11350	COG4657	Part of a membrane complex involved in electron transport
AWO_RS11355	COG4660	Part of a membrane complex involved in electron transport
AWO_RS11360	COG4659	FMN binding
AWO_RS11365	COG4658	electron transport chain
AWO_RS11370	COG4656	Part of a membrane complex involved in electron transport
AWO_RS11375	COG1362	aminopeptidase activity
AWO_RS11380	COG4224	UPF0291 protein
AWO_RS11385	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AWO_RS11390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AWO_RS11395	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AWO_RS11400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AWO_RS11410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AWO_RS11425	COG0546	phosphoglycolate phosphatase activity
AWO_RS11435	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AWO_RS11440	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AWO_RS11445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AWO_RS11460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AWO_RS11465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AWO_RS11470	COG0107	imidazoleglycerol-phosphate synthase activity
AWO_RS11475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AWO_RS11475	COG0140	phosphoribosyl-ATP diphosphatase activity
AWO_RS11480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AWO_RS11485	COG1116	anion transmembrane transporter activity
AWO_RS11495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWO_RS11500	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWO_RS11505	COG2391	methyltransferase activity
AWO_RS11520	COG1116	anion transmembrane transporter activity
AWO_RS11540	COG0463	Glycosyl transferase, family 2
AWO_RS11550	COG0583	DNA-binding transcription factor activity
AWO_RS11555	COG2391	methyltransferase activity
AWO_RS11560	COG2391	methyltransferase activity
AWO_RS11570	COG1230	cation diffusion facilitator family transporter
AWO_RS11575	COG2814	Major facilitator Superfamily
AWO_RS11580	COG0640	Transcriptional regulator
AWO_RS11600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AWO_RS11640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWO_RS11650	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AWO_RS11655	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AWO_RS11660	COG1640	4-alpha-glucanotransferase
AWO_RS11690	COG0248	Ppx GppA phosphatase
AWO_RS11695	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AWO_RS11710	COG5012	cobalamin binding
AWO_RS11735	COG5012	cobalamin binding
AWO_RS11740	COG1917	Cupin 2, conserved barrel domain protein
AWO_RS11740	COG2207	Transcriptional regulator
AWO_RS11750	COG1940	carbohydrate kinase activity
AWO_RS11760	COG0577	efflux transmembrane transporter activity
AWO_RS11770	COG1136	(ABC) transporter
AWO_RS11770	COG0577	efflux transmembrane transporter activity
AWO_RS11780	COG1131	(ABC) transporter
AWO_RS11785	COG1725	Transcriptional regulator
AWO_RS11790	COG0840	transmembrane signaling receptor activity
AWO_RS11805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWO_RS11810	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AWO_RS11815	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
AWO_RS11825	COG0321	lipoyl(octanoyl) transferase activity
AWO_RS11825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWO_RS11835	COG1028	Short-chain dehydrogenase reductase Sdr
AWO_RS11840	COG3321	synthase
AWO_RS11840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AWO_RS11840	COG0318	PFAM AMP-dependent synthetase and ligase
AWO_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
AWO_RS11840	COG0300	oxidoreductase activity
AWO_RS11845	COG1691	(AIR) carboxylase
AWO_RS11850	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AWO_RS11855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWO_RS11870	COG0519	Catalyzes the synthesis of GMP from XMP
AWO_RS11880	COG3608	succinylglutamate desuccinylase aspartoacylase
AWO_RS11880	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AWO_RS11885	COG0402	S-adenosylhomocysteine deaminase activity
AWO_RS11890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AWO_RS11955	COG0789	Transcriptional regulator
AWO_RS11960	COG2217	Heavy metal translocating P-type atpase
AWO_RS11980	COG0191	fructose-bisphosphate aldolase activity
AWO_RS11985	COG3958	Transketolase
AWO_RS11990	COG3959	Transketolase, thiamine diphosphate binding domain
AWO_RS11995	COG0698	ribose 5-phosphate isomerase
AWO_RS12000	COG3958	Transketolase
AWO_RS12005	COG3959	Transketolase, thiamine diphosphate binding domain
AWO_RS12010	COG3835	regulator
AWO_RS12020	COG1028	Short-chain dehydrogenase reductase Sdr
AWO_RS12030	COG1028	Short-chain dehydrogenase reductase Sdr
AWO_RS12040	COG0095	Lipoate-protein ligase
AWO_RS12045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWO_RS12055	COG0022	dehydrogenase e1 component
AWO_RS12060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWO_RS12080	COG5001	Diguanylate cyclase
AWO_RS12080	COG3300	MHYT domain
AWO_RS12090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWO_RS12100	COG1842	Phage shock protein A
AWO_RS12110	COG0840	transmembrane signaling receptor activity
AWO_RS12140	COG0745	RESPONSE REGULATOR receiver
AWO_RS12145	COG0704	Plays a role in the regulation of phosphate uptake
AWO_RS12150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AWO_RS12155	COG0581	inorganic phosphate transmembrane transporter activity
AWO_RS12160	COG0573	inorganic phosphate transmembrane transporter activity
AWO_RS12165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWO_RS12170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWO_RS12180	COG0513	Belongs to the DEAD box helicase family
AWO_RS12190	COG2268	Band 7 protein
AWO_RS12200	COG4977	sequence-specific DNA binding
AWO_RS12230	COG0523	cobalamin synthesis protein
AWO_RS12240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWO_RS12245	COG0482	sulfurtransferase activity
AWO_RS12285	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AWO_RS12295	COG1394	ATPase activity, coupled to movement of substances
AWO_RS12340	COG2217	Heavy metal translocating P-type atpase
AWO_RS12345	COG1937	Protein conserved in bacteria
AWO_RS12435	COG2226	methyltransferase
AWO_RS12445	COG1477	protein flavinylation
AWO_RS12460	COG5002	protein histidine kinase activity
AWO_RS12465	COG0745	RESPONSE REGULATOR receiver
AWO_RS12475	COG1070	Carbohydrate kinase
AWO_RS12480	COG5564	TIM-barrel signal transduction protein
AWO_RS12490	COG2204	response regulator
AWO_RS12495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AWO_RS12500	COG2384	SAM-dependent methyltransferase
AWO_RS12505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWO_RS12510	COG0358	DNA primase activity
AWO_RS12520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AWO_RS12520	COG0674	pyruvate-flavodoxin oxidoreductase activity
AWO_RS12520	COG1013	pyruvate-flavodoxin oxidoreductase activity
AWO_RS12520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AWO_RS12525	COG1115	amino acid carrier protein
AWO_RS12530	COG0686	Belongs to the AlaDH PNT family
AWO_RS12535	COG1522	sequence-specific DNA binding
AWO_RS12545	COG0473	3-isopropylmalate dehydrogenase activity
AWO_RS12570	COG0166	Belongs to the GPI family
AWO_RS12575	COG0656	L-ascorbic acid biosynthetic process
AWO_RS12585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AWO_RS12605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AWO_RS12610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AWO_RS12620	COG0126	phosphoglycerate kinase activity
AWO_RS12635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AWO_RS12650	COG1157	protein secretion by the type III secretion system
AWO_RS12660	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWO_RS12670	COG1677	Flagellar hook-basal body complex protein FliE
AWO_RS12675	COG1558	bacterial-type flagellum-dependent cell motility
AWO_RS12680	COG1815	bacterial-type flagellum-dependent cell motility
AWO_RS12695	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AWO_RS12705	COG0643	Histidine kinase
AWO_RS12705	COG2198	Histidine kinase
AWO_RS12715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AWO_RS12755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AWO_RS12775	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AWO_RS12780	COG2089	acid synthase
AWO_RS12800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWO_RS12805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWO_RS12830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AWO_RS12835	COG1256	bacterial-type flagellum assembly
AWO_RS12835	COG4786	Flagellar basal body rod
AWO_RS12850	COG2201	protein-glutamate methylesterase activity
AWO_RS12855	COG0835	chemotaxis
AWO_RS12860	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AWO_RS12865	COG1776	CheC inhibitor of MCP methylation
AWO_RS12880	COG4786	Flagellar basal body rod
AWO_RS12885	COG1191	sigma factor activity
AWO_RS12890	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AWO_RS12895	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AWO_RS12900	COG1684	flagellar biosynthetic protein fliR
AWO_RS12910	COG1338	Plays a role in the flagellum-specific transport system
AWO_RS12920	COG2201	protein-glutamate methylesterase activity
AWO_RS12925	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWO_RS12925	COG1776	CheC inhibitor of MCP methylation
AWO_RS12930	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWO_RS12960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AWO_RS12970	COG1283	sodium-dependent phosphate transmembrane transporter activity
AWO_RS12975	COG0423	glycine-tRNA ligase activity
AWO_RS12985	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AWO_RS12990	COG1307	EDD domain protein, DegV family
AWO_RS13000	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AWO_RS13005	COG0322	excinuclease ABC activity
AWO_RS13015	COG1278	Cold shock
AWO_RS13040	COG0556	nucleotide-excision repair
AWO_RS13045	COG3409	Peptidoglycan-binding domain 1 protein
AWO_RS13045	COG0793	Belongs to the peptidase S41A family
AWO_RS13055	COG2177	Part of the ABC transporter FtsEX involved in
AWO_RS13060	COG2884	Cell division ATP-binding protein ftsE
AWO_RS13065	COG0741	lytic transglycosylase activity
AWO_RS13065	COG0739	heme binding
AWO_RS13065	COG1196	nuclear chromosome segregation
AWO_RS13075	COG1454	alcohol dehydrogenase
AWO_RS13105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AWO_RS13110	COG0750	zinc metalloprotease
AWO_RS13115	COG4589	Belongs to the CDS family
AWO_RS13135	COG0561	phosphatase activity
AWO_RS13170	COG1074	ATP-dependent DNA helicase activity
AWO_RS13175	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AWO_RS13185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AWO_RS13195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWO_RS13200	COG1191	sigma factor activity
AWO_RS13205	COG2172	sigma factor antagonist activity
AWO_RS13225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWO_RS13230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWO_RS13235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AWO_RS13240	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AWO_RS13245	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AWO_RS13265	COG4656	Part of a membrane complex involved in electron transport
AWO_RS13270	COG1012	belongs to the aldehyde dehydrogenase family
AWO_RS13285	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
AWO_RS13300	COG4869	propanediol catabolic process
AWO_RS13305	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AWO_RS13345	COG2201	protein-glutamate methylesterase activity
AWO_RS13350	COG2972	Histidine kinase
AWO_RS13390	COG3655	Transcriptional regulator
AWO_RS13425	COG0464	growth
AWO_RS13440	COG0189	ligase activity
AWO_RS13445	COG0189	ligase activity
AWO_RS13470	COG1366	Belongs to the anti-sigma-factor antagonist family
AWO_RS13475	COG5492	domain, Protein
AWO_RS13480	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AWO_RS13495	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AWO_RS13500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AWO_RS13505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AWO_RS13510	COG1079	Belongs to the binding-protein-dependent transport system permease family
AWO_RS13515	COG4603	Belongs to the binding-protein-dependent transport system permease family
AWO_RS13520	COG3845	ABC transporter
AWO_RS13575	COG2165	general secretion pathway protein
AWO_RS13580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWO_RS13590	COG2137	regulation of response to DNA damage stimulus
AWO_RS13615	COG1116	anion transmembrane transporter activity
AWO_RS13615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWO_RS13620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWO_RS13655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWO_RS13660	COG1610	YqeY-like protein
AWO_RS13665	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AWO_RS13670	COG0537	adenosine 5'-monophosphoramidase activity
AWO_RS13675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AWO_RS13680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AWO_RS13685	COG2264	protein methyltransferase activity
AWO_RS13695	COG4917	ethanolamine utilization protein
AWO_RS13700	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AWO_RS13705	COG1959	2 iron, 2 sulfur cluster binding
AWO_RS13715	COG0484	heat shock protein binding
AWO_RS13720	COG0443	Heat shock 70 kDa protein
AWO_RS13725	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AWO_RS13730	COG1420	regulation of RNA biosynthetic process
AWO_RS13735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AWO_RS13740	COG2365	Tyrosine phosphatase family
AWO_RS13745	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AWO_RS13790	COG5464	transposase or invertase
AWO_RS13795	COG5464	transposase or invertase
AWO_RS13825	COG0840	transmembrane signaling receptor activity
AWO_RS13855	COG1481	regulation of sporulation
AWO_RS13860	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AWO_RS13865	COG1660	Displays ATPase and GTPase activities
AWO_RS13870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AWO_RS13880	COG1040	competence protein
AWO_RS13890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWO_RS13930	COG2878	Part of a membrane complex involved in electron transport
AWO_RS13945	COG4717	serine-type aminopeptidase activity
AWO_RS13965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AWO_RS13970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AWO_RS13975	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AWO_RS13980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AWO_RS14020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AWO_RS14025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AWO_RS14030	COG5002	protein histidine kinase activity
AWO_RS14035	COG0745	RESPONSE REGULATOR receiver
AWO_RS14065	COG0671	phosphoesterase, PA-phosphatase related
AWO_RS14070	COG0586	Pfam SNARE associated Golgi protein
AWO_RS14075	COG2211	Major facilitator Superfamily
AWO_RS14115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AWO_RS14125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AWO_RS14145	COG0598	Magnesium transport protein CorA
AWO_RS14160	COG3199	ATP-NAD kinase
AWO_RS14175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWO_RS14180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWO_RS14220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AWO_RS14230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AWO_RS14235	COG4149	molybdate abc transporter
AWO_RS14240	COG0725	ABC transporter, periplasmic molybdate-binding protein
AWO_RS14245	COG1910	domain protein
AWO_RS14250	COG1910	domain protein
AWO_RS14270	COG0531	amino acid
AWO_RS14280	COG0251	oxidation-reduction process
AWO_RS14285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWO_RS14315	COG0523	cobalamin synthesis protein
AWO_RS14330	COG5012	cobalamin binding
AWO_RS14335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AWO_RS14345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AWO_RS14355	COG5598	trimethylamine methyltransferase
AWO_RS14365	COG3829	transcription factor binding
AWO_RS14385	COG1773	rubredoxin
AWO_RS14385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AWO_RS14390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AWO_RS14395	COG0646	methionine synthase
AWO_RS14395	COG1410	methionine synthase
AWO_RS14415	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AWO_RS14420	COG0653	protein targeting
AWO_RS14430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AWO_RS14435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AWO_RS14460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AWO_RS14475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWO_RS14490	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AWO_RS14520	COG0628	permease
AWO_RS14530	COG1217	gtp-binding protein TYPA
AWO_RS14535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AWO_RS14540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AWO_RS14545	COG0101	tRNA pseudouridine synthase activity
AWO_RS14550	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AWO_RS14555	COG1122	ATPase activity
AWO_RS14560	COG1122	ATPase activity
AWO_RS14565	COG0203	ribosomal protein L17
AWO_RS14570	COG0202	RNA polymerase activity
AWO_RS14575	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AWO_RS14580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AWO_RS14590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AWO_RS14595	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AWO_RS14620	COG0200	Binds to the 23S rRNA
AWO_RS14625	COG1841	ribosomal large subunit assembly
AWO_RS14630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AWO_RS14635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AWO_RS14645	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AWO_RS14650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWO_RS14655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AWO_RS14665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AWO_RS14670	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AWO_RS14675	COG0255	Belongs to the universal ribosomal protein uL29 family
AWO_RS14680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AWO_RS14685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AWO_RS14690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AWO_RS14695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AWO_RS14700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AWO_RS14705	COG0089	rRNA binding
AWO_RS14710	COG0088	Forms part of the polypeptide exit tunnel
AWO_RS14715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AWO_RS14725	COG1307	EDD domain protein, DegV family
AWO_RS14735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWO_RS14760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWO_RS14765	COG0116	Belongs to the methyltransferase superfamily
AWO_RS14770	COG0124	histidyl-tRNA synthetase
AWO_RS14780	COG0628	permease
AWO_RS14785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AWO_RS14790	COG1802	Transcriptional regulator
AWO_RS14795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AWO_RS14800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AWO_RS14810	COG0710	3-dehydroquinate dehydratase activity
AWO_RS14930	COG0697	spore germination
AWO_RS14955	COG0840	transmembrane signaling receptor activity
AWO_RS14960	COG0840	transmembrane signaling receptor activity
AWO_RS14970	COG1131	(ABC) transporter
AWO_RS15000	COG3585	molybdate ion transport
AWO_RS15005	COG0583	DNA-binding transcription factor activity
AWO_RS15015	COG1136	(ABC) transporter
AWO_RS15015	COG0577	efflux transmembrane transporter activity
AWO_RS15020	COG2205	protein histidine kinase activity
AWO_RS15025	COG0745	RESPONSE REGULATOR receiver
AWO_RS15030	COG2226	methyltransferase
AWO_RS15040	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AWO_RS15045	COG1518	maintenance of DNA repeat elements
AWO_RS15100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWO_RS15105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWO_RS15110	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWO_RS15115	COG0022	dehydrogenase e1 component
AWO_RS15120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWO_RS15135	COG3732	PTS system glucitol sorbitol-specific
AWO_RS15155	COG0534	Mate efflux family protein
AWO_RS15165	COG3177	Filamentation induced by cAMP protein fic
AWO_RS15170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AWO_RS15190	COG0516	GMP reductase activity
AWO_RS15190	COG0517	IMP dehydrogenase activity
AWO_RS15200	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWO_RS15200	COG0022	dehydrogenase e1 component
AWO_RS15205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWO_RS15210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AWO_RS15215	COG0802	atpase or kinase
AWO_RS15225	COG0436	Aminotransferase
AWO_RS15230	COG4496	protein, YerC YecD
AWO_RS15235	COG0215	cysteine-tRNA ligase activity
AWO_RS15240	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AWO_RS15245	COG0534	Mate efflux family protein
AWO_RS15250	COG0513	Belongs to the DEAD box helicase family
AWO_RS15255	COG1396	sequence-specific DNA binding
AWO_RS15260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AWO_RS15260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AWO_RS15265	COG0504	CTP synthase activity
AWO_RS15270	COG1272	protein, Hemolysin III
AWO_RS15280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AWO_RS15290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWO_RS15310	COG0037	tRNA processing
AWO_RS15310	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AWO_RS15350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AWO_RS15350	COG0248	Ppx GppA phosphatase
AWO_RS15360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AWO_RS15365	COG0776	regulation of translation
AWO_RS15370	COG3956	TIGRFAM MazG family protein
AWO_RS15375	COG2244	polysaccharide biosynthetic process
AWO_RS15380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AWO_RS15385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AWO_RS15390	COG0193	aminoacyl-tRNA hydrolase activity
AWO_RS15400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AWO_RS15405	COG2088	sporulation resulting in formation of a cellular spore
AWO_RS15410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWO_RS15415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AWO_RS15440	COG0653	protein targeting
AWO_RS15445	COG5002	protein histidine kinase activity
AWO_RS15445	COG0642	Histidine kinase
AWO_RS15450	COG1725	Transcriptional regulator
AWO_RS15455	COG1131	(ABC) transporter
AWO_RS15470	COG1136	(ABC) transporter
AWO_RS15475	COG0577	efflux transmembrane transporter activity
AWO_RS15485	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
AWO_RS15490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWO_RS15495	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AWO_RS15500	COG1492	cobalamin metabolic process
AWO_RS15505	COG2099	Precorrin-6x reductase
AWO_RS15530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AWO_RS15535	COG0113	porphobilinogen synthase activity
AWO_RS15545	COG1648	precorrin-2 dehydrogenase activity
AWO_RS15545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AWO_RS15550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AWO_RS15555	COG5001	Diguanylate cyclase
AWO_RS15555	COG3300	MHYT domain
AWO_RS15565	COG0577	efflux transmembrane transporter activity
AWO_RS15570	COG1136	(ABC) transporter
AWO_RS15575	COG0642	Histidine kinase
AWO_RS15580	COG0745	RESPONSE REGULATOR receiver
AWO_RS15610	COG1136	(ABC) transporter
AWO_RS15625	COG2242	protein methyltransferase activity
AWO_RS15635	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AWO_RS15665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWO_RS15670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWO_RS15770	COG1082	Xylose isomerase domain protein TIM barrel
AWO_RS15800	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AWO_RS15805	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AWO_RS15870	COG0739	heme binding
AWO_RS15915	COG0740	serine-type endopeptidase activity
AWO_RS15985	COG1484	DNA-dependent DNA replication
AWO_RS16120	COG4115	mRNA cleavage
AWO_RS16190	COG1595	DNA-templated transcription, initiation
AWO_RS16195	COG2508	Transcriptional regulator
AWO_RS16215	COG1126	abc transporter atp-binding protein
AWO_RS16220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWO_RS16225	COG0765	amino acid transport
AWO_RS16230	COG0765	amino acid transport
AWO_RS16240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWO_RS16250	COG1595	DNA-templated transcription, initiation
AWO_RS16285	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AWO_RS16290	COG0745	RESPONSE REGULATOR receiver
AWO_RS16295	COG0778	Nitroreductase
AWO_RS16310	COG0765	amino acid transport
AWO_RS16315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWO_RS16350	COG0701	Predicted permease
AWO_RS16355	COG0523	cobalamin synthesis protein
AWO_RS16380	COG1131	(ABC) transporter
AWO_RS16390	COG1695	Transcriptional regulator
AWO_RS16395	COG0789	Transcriptional regulator
AWO_RS16395	COG4978	Transcriptional regulator
AWO_RS16405	COG1611	Belongs to the LOG family
AWO_RS16415	COG2207	Transcriptional regulator
AWO_RS16415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWO_RS16420	COG2814	Major facilitator Superfamily
AWO_RS16425	COG1309	transcriptional regulator
AWO_RS16430	COG2197	response regulator
AWO_RS16450	COG1131	(ABC) transporter
AWO_RS16480	COG3620	sequence-specific DNA binding
AWO_RS16485	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AWO_RS16490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWO_RS16490	COG0574	Belongs to the PEP-utilizing enzyme family
AWO_RS16505	COG0765	amino acid transport
AWO_RS16510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWO_RS16540	COG2770	Histidine kinase
AWO_RS16540	COG2208	phosphoserine phosphatase activity
AWO_RS16545	COG0534	Mate efflux family protein
AWO_RS16550	COG2207	Transcriptional regulator
AWO_RS16570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AWO_RS16580	COG3384	dioxygenase
AWO_RS16585	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AWO_RS16590	COG0667	Aldo Keto reductase
AWO_RS16595	COG1309	transcriptional regulator
AWO_RS16600	COG0789	Transcriptional regulator
AWO_RS16645	COG0535	radical SAM domain protein
AWO_RS16715	COG3708	Transcriptional regulator
AWO_RS16715	COG2207	Transcriptional regulator
AWO_RS16725	COG1136	(ABC) transporter
AWO_RS16725	COG0577	efflux transmembrane transporter activity
AWO_RS16735	COG2814	Major facilitator Superfamily
AWO_RS16750	COG5001	Diguanylate cyclase
AWO_RS16755	COG2199	diguanylate cyclase activity
AWO_RS16770	COG2814	Major facilitator Superfamily
AWO_RS16795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWO_RS16800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWO_RS16805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AWO_RS16810	COG0509	glycine decarboxylation via glycine cleavage system
AWO_RS16815	COG2198	Histidine kinase
AWO_RS16815	COG0643	Histidine kinase
AWO_RS16820	COG2201	protein-glutamate methylesterase activity
AWO_RS16830	COG0024	Methionine aminopeptidase
AWO_RS16835	COG2207	Transcriptional regulator
AWO_RS16865	COG3842	ATPase activity
AWO_RS16910	COG3300	MHYT domain
AWO_RS16910	COG5001	Diguanylate cyclase
AWO_RS16940	COG2207	Transcriptional regulator
AWO_RS16940	COG3708	Transcriptional regulator
AWO_RS16945	COG3588	fructose-bisphosphate aldolase
AWO_RS16955	COG2199	diguanylate cyclase activity
AWO_RS16970	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AWO_RS16975	COG1132	(ABC) transporter
AWO_RS17020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWO_RS17045	COG0456	acetyltransferase
AWO_RS17050	COG4335	DNA alkylation repair
AWO_RS17055	COG2201	protein-glutamate methylesterase activity
AWO_RS17065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWO_RS17100	COG3279	Response regulator of the LytR AlgR family
AWO_RS17150	COG1846	Transcriptional regulator
AWO_RS17170	COG1162	GTPase activity
AWO_RS17180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AWO_RS17190	COG0004	ammonium transporteR
AWO_RS17200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWO_RS17220	COG0009	L-threonylcarbamoyladenylate synthase
AWO_RS17230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AWO_RS17230	COG2207	Transcriptional regulator
AWO_RS17235	COG2814	Major facilitator Superfamily
AWO_RS17240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AWO_RS17250	COG3829	transcription factor binding
AWO_RS17250	COG3290	protein histidine kinase activity
AWO_RS17260	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AWO_RS17265	COG1012	belongs to the aldehyde dehydrogenase family
AWO_RS17300	COG1950	PFAM Membrane protein of
AWO_RS17315	COG4716	Myosin-crossreactive antigen
AWO_RS17365	COG2207	Transcriptional regulator
AWO_RS17365	COG3708	Transcriptional regulator
AWO_RS17390	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AWO_RS17415	COG1131	(ABC) transporter
AWO_RS17465	COG2909	trisaccharide binding
AWO_RS17495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWO_RS17500	COG0493	'glutamate synthase
AWO_RS17525	COG0251	oxidation-reduction process
AWO_RS17530	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AWO_RS17535	COG0531	amino acid
AWO_RS17545	COG1366	Belongs to the anti-sigma-factor antagonist family
AWO_RS17560	COG2274	protein secretion by the type I secretion system
AWO_RS17580	COG0789	Transcriptional regulator
AWO_RS17615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AWO_RS17650	COG5002	protein histidine kinase activity
AWO_RS17655	COG0745	RESPONSE REGULATOR receiver
AWO_RS17685	COG2169	Transcriptional regulator
AWO_RS17700	COG1309	transcriptional regulator
AWO_RS17760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AWO_RS17795	COG2801	Transposase and inactivated derivatives
AWO_RS17865	COG0739	heme binding
AWO_RS17910	COG0740	serine-type endopeptidase activity
AWO_RS18040	COG1396	sequence-specific DNA binding
AWO_RS18075	COG1511	domain protein
AWO_RS18080	COG3118	belongs to the thioredoxin family
AWO_RS18105	COG1774	PSP1 C-terminal conserved region
AWO_RS18120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AWO_RS18135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AWO_RS18145	COG0305	Participates in initiation and elongation during chromosome replication
AWO_RS18150	COG0359	binds to the 23S rRNA
AWO_RS18155	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AWO_RS18160	COG4241	membrane
AWO_RS18170	COG0629	single-stranded DNA binding
AWO_RS18175	COG0360	Binds together with S18 to 16S ribosomal RNA
AWO_RS18185	COG4481	Protein conserved in bacteria
AWO_RS18190	COG0668	transmembrane transport
AWO_RS18205	COG1475	DNA binding
AWO_RS18210	COG1192	Involved in chromosome partitioning
AWO_RS18215	COG0357	Ribosomal RNA small subunit methyltransferase G
AWO_RS18220	COG0445	tRNA wobble uridine modification
AWO_RS18225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AWO_RS18230	COG1847	R3H domain protein
AWO_RS18235	COG0706	membrane insertase activity
AWO_RS18240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AWO_RS18260	COG2226	methyltransferase
AWO_RS18275	COG3706	GGDEF domain
AWO_RS18290	COG1316	TRANSCRIPTIONal
AWO_RS18295	COG2770	Histidine kinase
AWO_RS18295	COG3437	response regulator, receiver
AWO_RS18305	COG2205	protein histidine kinase activity
AWO_RS18305	COG2770	Histidine kinase
AWO_RS18330	COG3835	regulator
AWO_RS18335	COG0697	spore germination
AWO_RS18340	COG1876	peptidase activity
AWO_RS18350	COG0569	domain protein
AWO_RS18360	COG3447	MASE1 domain protein
AWO_RS18360	COG5001	Diguanylate cyclase
AWO_RS18360	COG5002	protein histidine kinase activity
AWO_RS18375	COG5002	protein histidine kinase activity
AWO_RS18395	COG0840	transmembrane signaling receptor activity
AWO_RS18400	COG1309	transcriptional regulator
AWO_RS18405	COG0732	type I restriction modification DNA specificity domain
AWO_RS18415	COG1396	sequence-specific DNA binding
AWO_RS18435	COG0739	heme binding
AWO_RS18440	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AWO_RS18440	COG2199	diguanylate cyclase activity
AWO_RS18455	COG0840	transmembrane signaling receptor activity
AWO_RS18460	COG0583	DNA-binding transcription factor activity
AWO_RS18465	COG2414	aldehyde ferredoxin oxidoreductase
AWO_RS18515	COG1686	Belongs to the peptidase S11 family
AWO_RS18525	COG3447	MASE1 domain protein
AWO_RS18525	COG5002	protein histidine kinase activity
AWO_RS18525	COG5001	Diguanylate cyclase
AWO_RS18545	COG2203	Gaf domain
AWO_RS18545	COG3706	GGDEF domain
AWO_RS18545	COG4251	negative regulation of phosphorylation
AWO_RS18545	COG5001	Diguanylate cyclase
AWO_RS18555	COG0840	transmembrane signaling receptor activity
AWO_RS18585	COG3706	GGDEF domain
AWO_RS18605	COG0840	transmembrane signaling receptor activity
AWO_RS18615	COG2176	DNA-directed DNA polymerase activity
AWO_RS18635	COG0840	transmembrane signaling receptor activity
AWO_RS18645	COG3706	GGDEF domain
AWO_RS18660	COG0840	transmembrane signaling receptor activity
AWO_RS18660	COG0840	transmembrane signaling receptor activity
AWO_RS18695	COG5001	Diguanylate cyclase
AWO_RS18710	COG0758	DNA mediated transformation
AWO_RS18715	COG3706	GGDEF domain
AWO_RS18720	COG0840	transmembrane signaling receptor activity
AWO_RS18725	COG5434	Belongs to the glycosyl hydrolase 28 family
AWO_RS18745	COG0840	transmembrane signaling receptor activity
AWO_RS18760	COG0739	heme binding
AWO_RS18760	COG0741	lytic transglycosylase activity
AWO_RS18760	COG1196	nuclear chromosome segregation
AWO_RS18770	COG4251	negative regulation of phosphorylation
AWO_RS18770	COG5001	Diguanylate cyclase
AWO_RS18770	COG2203	Gaf domain
AWO_RS18770	COG3706	GGDEF domain
AWO_RS18820	COG0322	excinuclease ABC activity
AWO_RS18825	COG1309	transcriptional regulator
AWO_RS18830	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWO_RS18870	COG1396	sequence-specific DNA binding
AWO_RS18895	COG0840	transmembrane signaling receptor activity
AWO_RS18900	COG2199	diguanylate cyclase activity
AWO_RS18935	COG4978	Transcriptional regulator
AWO_RS18935	COG0789	Transcriptional regulator
AWO_RS18940	COG0840	transmembrane signaling receptor activity
AWO_RS18950	COG2340	Cysteine-rich secretory protein family