locus-tag	class	description
acear_RS00010	COG0592	DNA-directed DNA polymerase activity
acear_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
acear_RS00035	COG0187	DNA topoisomerase II activity
acear_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
acear_RS00070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
acear_RS00075	COG0616	signal peptide processing
acear_RS00085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
acear_RS00090	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
acear_RS00095	COG1321	iron dependent repressor
acear_RS00135	COG3546	catalase activity
acear_RS00155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
acear_RS00160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
acear_RS00165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
acear_RS00200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
acear_RS00205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
acear_RS00210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
acear_RS00220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
acear_RS00230	COG0674	pyruvate-flavodoxin oxidoreductase activity
acear_RS00235	COG1013	pyruvate-flavodoxin oxidoreductase activity
acear_RS00255	COG0517	IMP dehydrogenase activity
acear_RS00255	COG0516	GMP reductase activity
acear_RS00265	COG1728	Protein conserved in bacteria
acear_RS00270	COG0470	DNA polymerase III
acear_RS00275	COG1774	PSP1 C-terminal conserved region
acear_RS00285	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
acear_RS00295	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
acear_RS00300	COG2002	toxin-antitoxin pair type II binding
acear_RS00315	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
acear_RS00315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
acear_RS00320	COG0084	hydrolase, TatD family'
acear_RS00330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
acear_RS00335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
acear_RS00345	COG4466	Protein conserved in bacteria
acear_RS00350	COG1414	Transcriptional regulator
acear_RS00355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
acear_RS00360	COG0543	2 iron, 2 sulfur cluster binding
acear_RS00380	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
acear_RS00415	COG1115	amino acid carrier protein
acear_RS00445	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
acear_RS00450	COG1376	ErfK ybiS ycfS ynhG family protein
acear_RS00455	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
acear_RS00465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
acear_RS00475	COG0789	Transcriptional regulator
acear_RS00480	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
acear_RS00485	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
acear_RS00490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
acear_RS00495	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
acear_RS00500	COG0193	aminoacyl-tRNA hydrolase activity
acear_RS00510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
acear_RS00515	COG2002	toxin-antitoxin pair type II binding
acear_RS00520	COG2244	polysaccharide biosynthetic process
acear_RS00525	COG3956	TIGRFAM MazG family protein
acear_RS00530	COG1686	Belongs to the peptidase S11 family
acear_RS00535	COG2385	sporulation resulting in formation of a cellular spore
acear_RS00555	COG2183	response to ionizing radiation
acear_RS00560	COG1098	S1 RNA binding domain
acear_RS00565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
acear_RS00570	COG0573	inorganic phosphate transmembrane transporter activity
acear_RS00575	COG0581	inorganic phosphate transmembrane transporter activity
acear_RS00590	COG0248	Ppx GppA phosphatase
acear_RS00610	COG2208	phosphoserine phosphatase activity
acear_RS00615	COG0037	tRNA processing
acear_RS00620	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
acear_RS00620	COG0037	tRNA processing
acear_RS00625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
acear_RS00630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
acear_RS00640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
acear_RS00645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
acear_RS00650	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
acear_RS00660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
acear_RS00665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
acear_RS00675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
acear_RS00675	COG5322	oxidoreductase activity
acear_RS00680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
acear_RS00685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
acear_RS00700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
acear_RS00770	COG3880	PFAM UvrB UvrC protein
acear_RS00775	COG3869	Catalyzes the specific phosphorylation of arginine residues in
acear_RS00780	COG0542	response to heat
acear_RS00785	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
acear_RS00790	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
acear_RS00795	COG1329	Transcriptional regulator
acear_RS00800	COG4956	integral membrane protein (PIN domain superfamily)
acear_RS00805	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
acear_RS00820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
acear_RS00820	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
acear_RS00825	COG1045	serine acetyltransferase
acear_RS00830	COG0215	cysteine-tRNA ligase activity
acear_RS00835	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
acear_RS00845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
acear_RS00865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
acear_RS00870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
acear_RS00875	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
acear_RS00885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
acear_RS00890	COG0081	regulation of translation
acear_RS00895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
acear_RS00900	COG0222	ribosome binding
acear_RS00905	COG0085	RNA polymerase activity
acear_RS00910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
acear_RS00915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
acear_RS00925	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
acear_RS00930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
acear_RS00940	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
acear_RS00945	COG0088	Forms part of the polypeptide exit tunnel
acear_RS00950	COG0089	rRNA binding
acear_RS00955	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
acear_RS00960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
acear_RS00965	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
acear_RS00970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
acear_RS00975	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
acear_RS00985	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
acear_RS00990	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
acear_RS00995	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
acear_RS01000	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
acear_RS01005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
acear_RS01010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
acear_RS01015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
acear_RS01020	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
acear_RS01030	COG0200	Binds to the 23S rRNA
acear_RS01040	COG0563	adenylate kinase activity
acear_RS01050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
acear_RS01055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
acear_RS01065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
acear_RS01070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
acear_RS01080	COG0203	ribosomal protein L17
acear_RS01085	COG1122	ATPase activity
acear_RS01090	COG1122	ATPase activity
acear_RS01095	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
acear_RS01100	COG0101	tRNA pseudouridine synthase activity
acear_RS01105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
acear_RS01110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
acear_RS01115	COG0010	Belongs to the arginase family
acear_RS01120	COG3885	ferrous iron binding
acear_RS01120	COG2078	PFAM AMMECR1 domain protein
acear_RS01135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
acear_RS01145	COG0277	FAD linked oxidase domain protein
acear_RS01145	COG0247	lactate metabolic process
acear_RS01150	COG0129	dihydroxy-acid dehydratase activity
acear_RS01155	COG0028	Belongs to the TPP enzyme family
acear_RS01160	COG0440	acetolactate synthase activity
acear_RS01165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
acear_RS01170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
acear_RS01175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
acear_RS01180	COG0066	3-isopropylmalate dehydratase activity
acear_RS01185	COG0473	3-isopropylmalate dehydrogenase activity
acear_RS01190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
acear_RS01195	COG0471	metal ion transport
acear_RS01215	COG1482	cell wall glycoprotein biosynthetic process
acear_RS01220	COG2385	sporulation resulting in formation of a cellular spore
acear_RS01220	COG2385	sporulation resulting in formation of a cellular spore
acear_RS01225	COG0613	PHP domain protein
acear_RS01240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
acear_RS01245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
acear_RS01245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
acear_RS01250	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
acear_RS01250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
acear_RS01260	COG0840	transmembrane signaling receptor activity
acear_RS01265	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
acear_RS01270	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
acear_RS01310	COG4796	Type ii and iii secretion system protein
acear_RS01350	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
acear_RS01355	COG1040	competence protein
acear_RS01390	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
acear_RS01395	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
acear_RS01405	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
acear_RS01425	COG1516	flagellar protein fliS
acear_RS01460	COG1606	tRNA processing
acear_RS01465	COG1691	(AIR) carboxylase
acear_RS01480	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
acear_RS01500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
acear_RS01505	COG0765	amino acid transport
acear_RS01515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
acear_RS01520	COG0653	protein targeting
acear_RS01525	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
acear_RS01550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
acear_RS01555	COG3959	Transketolase, thiamine diphosphate binding domain
acear_RS01560	COG3958	Transketolase
acear_RS01565	COG0793	Belongs to the peptidase S41A family
acear_RS01575	COG0556	nucleotide-excision repair
acear_RS01580	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
acear_RS01585	COG0322	excinuclease ABC activity
acear_RS01600	COG1105	Belongs to the carbohydrate kinase PfkB family
acear_RS01620	COG1937	Protein conserved in bacteria
acear_RS01630	COG0561	phosphatase activity
acear_RS01635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
acear_RS01640	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
acear_RS01645	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
acear_RS01650	COG0438	transferase activity, transferring glycosyl groups
acear_RS01655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
acear_RS01665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
acear_RS01665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
acear_RS01670	COG1940	carbohydrate kinase activity
acear_RS01690	COG1543	Belongs to the glycosyl hydrolase 57 family
acear_RS01700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
acear_RS01725	COG1660	Displays ATPase and GTPase activities
acear_RS01730	COG0391	Required for morphogenesis under gluconeogenic growth conditions
acear_RS01735	COG1481	regulation of sporulation
acear_RS01740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
acear_RS01760	COG0126	phosphoglycerate kinase activity
acear_RS01765	COG0149	triose-phosphate isomerase activity
acear_RS01770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
acear_RS01775	COG0148	phosphopyruvate hydratase activity
acear_RS01780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
acear_RS01785	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
acear_RS01805	COG0557	exoribonuclease II activity
acear_RS01810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
acear_RS01835	COG1361	Conserved repeat domain
acear_RS01850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
acear_RS01850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
acear_RS01855	COG0312	modulator of DNA gyrase
acear_RS01860	COG0312	modulator of DNA gyrase
acear_RS01865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
acear_RS01870	COG1971	Probably functions as a manganese efflux pump
acear_RS01875	COG0237	dephospho-CoA kinase activity
acear_RS01880	COG1803	Methylglyoxal synthase
acear_RS01885	COG0741	lytic transglycosylase activity
acear_RS01895	COG0709	Synthesizes selenophosphate from selenide and ATP
acear_RS01920	COG5012	cobalamin binding
acear_RS01935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
acear_RS01945	COG1181	Belongs to the D-alanine--D-alanine ligase family
acear_RS01955	COG0583	DNA-binding transcription factor activity
acear_RS01965	COG4656	Part of a membrane complex involved in electron transport
acear_RS01970	COG1805	sodium ion transport
acear_RS01980	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
acear_RS01985	COG4657	Part of a membrane complex involved in electron transport
acear_RS01990	COG2871	sodium ion transport
acear_RS02005	COG0442	prolyl-tRNA aminoacylation
acear_RS02015	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
acear_RS02020	COG0488	(ABC) transporter
acear_RS02025	COG1136	(ABC) transporter
acear_RS02025	COG0577	efflux transmembrane transporter activity
acear_RS02030	COG0577	efflux transmembrane transporter activity
acear_RS02030	COG1136	(ABC) transporter
acear_RS02055	COG1773	rubredoxin
acear_RS02060	COG0426	domain, Protein
acear_RS02070	COG1278	Cold shock
acear_RS02080	COG2959	enzyme of heme biosynthesis
acear_RS02100	COG0569	domain protein
acear_RS02105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
acear_RS02110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
acear_RS02115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
acear_RS02120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
acear_RS02125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
acear_RS02130	COG0569	domain protein
acear_RS02135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
acear_RS02140	COG0569	domain protein
acear_RS02145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
acear_RS02150	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
acear_RS02155	COG0072	phenylalanine-tRNA ligase activity
acear_RS02155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
acear_RS02205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
acear_RS02205	COG1796	DNA polymerase
acear_RS02215	COG1193	negative regulation of DNA recombination
acear_RS02225	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
acear_RS02230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
acear_RS02250	COG0628	permease
acear_RS02255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
acear_RS02260	COG4472	Bacterial protein of unknown function (DUF965)
acear_RS02270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
acear_RS02285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
acear_RS02290	COG4122	O-methyltransferase activity
acear_RS02295	COG0826	peptidase U32
acear_RS02340	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
acear_RS02355	COG0644	oxidoreductase
acear_RS02360	COG2002	toxin-antitoxin pair type II binding
acear_RS02365	COG4175	Glycine betaine
acear_RS02365	COG3448	diguanylate cyclase activity
acear_RS02375	COG2113	Glycine betaine
acear_RS02385	COG4176	ABC-type proline glycine betaine transport system permease component
acear_RS02390	COG5012	cobalamin binding
acear_RS02405	COG5598	trimethylamine methyltransferase
acear_RS02410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
acear_RS02415	COG5012	cobalamin binding
acear_RS02425	COG0840	transmembrane signaling receptor activity
acear_RS02445	COG0471	metal ion transport
acear_RS02450	COG3426	butyrate kinase activity
acear_RS02455	COG0280	phosphate acetyltransferase
acear_RS02465	COG0674	pyruvate-flavodoxin oxidoreductase activity
acear_RS02465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
acear_RS02470	COG1013	pyruvate-flavodoxin oxidoreductase activity
acear_RS02485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
acear_RS02490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
acear_RS02495	COG0167	dihydroorotate dehydrogenase activity
acear_RS02515	COG3135	benzoate transporter
acear_RS02520	COG3842	ATPase activity
acear_RS02530	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
acear_RS02530	COG3608	succinylglutamate desuccinylase aspartoacylase
acear_RS02560	COG3608	succinylglutamate desuccinylase aspartoacylase
acear_RS02560	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
acear_RS02570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
acear_RS02590	COG4865	methylaspartate mutase activity
acear_RS02610	COG3290	protein histidine kinase activity
acear_RS02610	COG3829	transcription factor binding
acear_RS02625	COG1757	Na H antiporter
acear_RS02630	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
acear_RS02635	COG1914	H( )-stimulated, divalent metal cation uptake system
acear_RS02650	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
acear_RS02655	COG1984	allophanate hydrolase subunit 2
acear_RS02670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
acear_RS02675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
acear_RS02715	COG0544	peptidyl-prolyl cis-trans isomerase activity
acear_RS02720	COG0740	serine-type endopeptidase activity
acear_RS02725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
acear_RS02730	COG0470	DNA polymerase III
acear_RS02730	COG1067	ATP-dependent peptidase activity
acear_RS02735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
acear_RS02740	COG0218	Necessary for normal cell division and for the maintenance of normal septation
acear_RS02750	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
acear_RS02755	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
acear_RS02760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
acear_RS02765	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
acear_RS02770	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
acear_RS02775	COG0402	S-adenosylhomocysteine deaminase activity
acear_RS02780	COG0163	prenyltransferase activity
acear_RS02785	COG0525	valine-tRNA ligase activity
acear_RS02800	COG1757	Na H antiporter
acear_RS02805	COG0252	asparaginase activity
acear_RS02810	COG0281	malic enzyme
acear_RS02815	COG1027	Aspartate ammonia-lyase
acear_RS02820	COG1794	racemase activity, acting on amino acids and derivatives
acear_RS02835	COG0372	Belongs to the citrate synthase family
acear_RS02865	COG0285	dihydrofolate synthase activity
acear_RS02880	COG0517	IMP dehydrogenase activity
acear_RS02880	COG0516	GMP reductase activity
acear_RS02890	COG4656	Part of a membrane complex involved in electron transport
acear_RS02895	COG4658	electron transport chain
acear_RS02900	COG4659	FMN binding
acear_RS02905	COG4660	Part of a membrane complex involved in electron transport
acear_RS02910	COG4657	Part of a membrane complex involved in electron transport
acear_RS02915	COG2878	Part of a membrane complex involved in electron transport
acear_RS02915	COG1245	4Fe-4S binding domain
acear_RS02920	COG2226	methyltransferase
acear_RS02925	COG0142	geranyltranstransferase activity
acear_RS02930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
acear_RS02935	COG1648	precorrin-2 dehydrogenase activity
acear_RS02935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
acear_RS02940	COG0181	hydroxymethylbilane synthase activity
acear_RS02950	COG0113	porphobilinogen synthase activity
acear_RS02955	COG1522	sequence-specific DNA binding
acear_RS02960	COG1522	sequence-specific DNA binding
acear_RS02965	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
acear_RS02975	COG0746	molybdenum cofactor guanylyltransferase activity
acear_RS02985	COG1763	Mo-molybdopterin cofactor biosynthetic process
acear_RS02995	COG0424	maF-like protein
acear_RS03000	COG2003	Belongs to the UPF0758 family
acear_RS03005	COG1077	Cell shape determining protein MreB Mrl
acear_RS03020	COG0768	penicillin binding
acear_RS03030	COG2894	cell division
acear_RS03035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
acear_RS03040	COG0772	Belongs to the SEDS family
acear_RS03060	COG1530	ribonuclease E activity
acear_RS03075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
acear_RS03080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
acear_RS03085	COG1534	Rna-binding protein
acear_RS03090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
acear_RS03095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
acear_RS03110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
acear_RS03115	COG1713	HD superfamily hydrolase involved in NAD metabolism
acear_RS03125	COG0799	negative regulation of ribosome biogenesis
acear_RS03135	COG0495	leucyl-tRNA aminoacylation
acear_RS03150	COG4974	Belongs to the 'phage' integrase family
acear_RS03155	COG5000	phosphorelay sensor kinase activity
acear_RS03210	COG0268	Binds directly to 16S ribosomal RNA
acear_RS03220	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
acear_RS03230	COG0481	GTPase activity
acear_RS03235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
acear_RS03240	COG1420	regulation of RNA biosynthetic process
acear_RS03245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
acear_RS03250	COG0443	Heat shock 70 kDa protein
acear_RS03255	COG0484	heat shock protein binding
acear_RS03265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
acear_RS03270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
acear_RS03275	COG0537	adenosine 5'-monophosphoramidase activity
acear_RS03280	COG1610	YqeY-like protein
acear_RS03285	COG1030	water channel activity
acear_RS03290	COG4864	UPF0365 protein
acear_RS03300	COG0659	secondary active sulfate transmembrane transporter activity
acear_RS03315	COG1702	phosphate starvation-inducible protein PhoH
acear_RS03320	COG1480	7TM receptor with intracellular HD hydrolase
acear_RS03325	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
acear_RS03330	COG1253	flavin adenine dinucleotide binding
acear_RS03340	COG0295	cytidine deaminase activity
acear_RS03350	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
acear_RS03355	COG2239	Acts as a magnesium transporter
acear_RS03360	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
acear_RS03375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
acear_RS03380	COG0444	Belongs to the ABC transporter superfamily
acear_RS03385	COG4608	Belongs to the ABC transporter superfamily
acear_RS03400	COG0243	molybdopterin cofactor binding
acear_RS03405	COG0028	Belongs to the TPP enzyme family
acear_RS03410	COG0440	acetolactate synthase activity
acear_RS03420	COG0095	Lipoate-protein ligase
acear_RS03425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
acear_RS03455	COG0513	Belongs to the DEAD box helicase family
acear_RS03475	COG0326	Molecular chaperone. Has ATPase activity
acear_RS03480	COG3385	transposase activity
acear_RS03485	COG1396	sequence-specific DNA binding
acear_RS03520	COG0375	protein maturation
acear_RS03525	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
acear_RS03530	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
acear_RS03555	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
acear_RS03560	COG1132	(ABC) transporter
acear_RS03565	COG1132	(ABC) transporter
acear_RS03590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
acear_RS03590	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
acear_RS03610	COG1381	Involved in DNA repair and RecF pathway recombination
acear_RS03620	COG0752	glycyl-tRNA synthetase alpha subunit
acear_RS03625	COG0751	glycine-tRNA ligase activity
acear_RS03630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
acear_RS03635	COG0517	IMP dehydrogenase activity
acear_RS03640	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
acear_RS03645	COG1494	fructose-1,6-bisphosphatase
acear_RS03650	COG0574	Belongs to the PEP-utilizing enzyme family
acear_RS03650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
acear_RS03655	COG0431	NADPH-dependent FMN reductase
acear_RS03660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
acear_RS03670	COG0358	DNA primase activity
acear_RS03675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
acear_RS03690	COG2384	SAM-dependent methyltransferase
acear_RS03695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
acear_RS03715	COG0077	Prephenate dehydratase
acear_RS03715	COG1605	Chorismate mutase
acear_RS03720	COG0217	transcriptional regulatory protein
acear_RS03730	COG0632	four-way junction helicase activity
acear_RS03735	COG2255	four-way junction helicase activity
acear_RS03745	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
acear_RS03750	COG0343	queuine tRNA-ribosyltransferase activity
acear_RS03770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
acear_RS03775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
acear_RS03790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
acear_RS03800	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
acear_RS03800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
acear_RS03805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
acear_RS03810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
acear_RS03815	COG1490	D-aminoacyl-tRNA deacylase activity
acear_RS03820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
acear_RS03830	COG0124	histidyl-tRNA synthetase
acear_RS03835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
acear_RS03840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
acear_RS03845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
acear_RS03850	COG1739	Uncharacterized protein family UPF0029
acear_RS03855	COG2364	Membrane
acear_RS03860	COG1959	2 iron, 2 sulfur cluster binding
acear_RS03865	COG1104	cysteine desulfurase activity
acear_RS03965	COG2431	L-lysine efflux transmembrane transporter activity
acear_RS03970	COG0275	rRNA processing
acear_RS03980	COG0768	penicillin binding
acear_RS03985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
acear_RS03990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
acear_RS03995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
acear_RS04000	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
acear_RS04005	COG0772	Belongs to the SEDS family
acear_RS04010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
acear_RS04015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
acear_RS04020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
acear_RS04025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
acear_RS04030	COG1181	Belongs to the D-alanine--D-alanine ligase family
acear_RS04045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
acear_RS04055	COG1191	sigma factor activity
acear_RS04065	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
acear_RS04075	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
acear_RS04105	COG0310	cobalt ion transport
acear_RS04115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
acear_RS04120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
acear_RS04125	COG1120	ATPase activity
acear_RS04130	COG4206	TonB-dependent receptor
acear_RS04140	COG0811	peptide transport
acear_RS04145	COG0848	biopolymer transport protein
acear_RS04160	COG0310	cobalt ion transport
acear_RS04170	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
acear_RS04175	COG1122	ATPase activity
acear_RS04180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
acear_RS04185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
acear_RS04190	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
acear_RS04195	COG1720	tRNA m6t6A37 methyltransferase activity
acear_RS04230	COG0310	cobalt ion transport
acear_RS04235	COG0310	cobalt ion transport
acear_RS04260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
acear_RS04265	COG1473	amidohydrolase
acear_RS04270	COG1929	Belongs to the glycerate kinase type-1 family
acear_RS04320	COG0371	Dehydrogenase
acear_RS04350	COG0582	viral genome integration into host DNA
acear_RS04385	COG1518	maintenance of DNA repeat elements
acear_RS04385	COG1468	defense response to virus
acear_RS04390	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
acear_RS04425	COG1640	4-alpha-glucanotransferase
acear_RS04435	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
acear_RS04475	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
acear_RS04480	COG1492	cobalamin metabolic process
acear_RS04485	COG1492	cobalamin metabolic process
acear_RS04490	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
acear_RS04505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
acear_RS04515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
acear_RS04520	COG0406	alpha-ribazole phosphatase activity
acear_RS04525	COG1191	sigma factor activity
acear_RS04535	COG1873	PFAM PRC-barrel domain
acear_RS04540	COG0864	Transcriptional regulator
acear_RS04545	COG1496	oxidoreductase activity
acear_RS04550	COG0745	RESPONSE REGULATOR receiver
acear_RS04555	COG5002	protein histidine kinase activity
acear_RS04565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
acear_RS04575	COG0745	RESPONSE REGULATOR receiver
acear_RS04580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
acear_RS04585	COG0573	inorganic phosphate transmembrane transporter activity
acear_RS04590	COG0581	inorganic phosphate transmembrane transporter activity
acear_RS04595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
acear_RS04600	COG0704	Plays a role in the regulation of phosphate uptake
acear_RS04610	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
acear_RS04615	COG5002	protein histidine kinase activity
acear_RS04635	COG3706	GGDEF domain
acear_RS04640	COG1151	hydroxylamine reductase activity
acear_RS04650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
acear_RS04655	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
acear_RS04665	COG2302	S4 RNA-binding domain
acear_RS04680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
acear_RS04685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
acear_RS04690	COG0425	Belongs to the sulfur carrier protein TusA family
acear_RS04700	COG1104	cysteine desulfurase activity
acear_RS04715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
acear_RS04720	COG0564	pseudouridine synthase activity
acear_RS04730	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
acear_RS04735	COG2233	PERMEase
acear_RS04740	COG0540	Belongs to the ATCase OTCase family
acear_RS04745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
acear_RS04750	COG0284	orotidine-5'-phosphate decarboxylase activity
acear_RS04755	COG0505	Belongs to the CarA family
acear_RS04760	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
acear_RS04765	COG0543	2 iron, 2 sulfur cluster binding
acear_RS04770	COG0167	dihydroorotate dehydrogenase activity
acear_RS04775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
acear_RS04785	COG4974	Belongs to the 'phage' integrase family
acear_RS04825	COG0662	Cupin 2, conserved barrel domain protein
acear_RS04850	COG4895	conserved protein (DUF2196)
acear_RS04855	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
acear_RS04870	COG2002	toxin-antitoxin pair type II binding
acear_RS04885	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
acear_RS04905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
acear_RS04910	COG5598	trimethylamine methyltransferase
acear_RS04915	COG5012	cobalamin binding
acear_RS04930	COG0840	transmembrane signaling receptor activity
acear_RS04955	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
acear_RS05010	COG2414	aldehyde ferredoxin oxidoreductase
acear_RS05025	COG1063	alcohol dehydrogenase
acear_RS05030	COG5012	cobalamin binding
acear_RS05040	COG0281	malic enzyme
acear_RS05060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
acear_RS05065	COG0835	chemotaxis
acear_RS05070	COG0643	Histidine kinase
acear_RS05070	COG2198	Histidine kinase
acear_RS05075	COG2201	protein-glutamate methylesterase activity
acear_RS05080	COG2201	protein-glutamate methylesterase activity
acear_RS05085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
acear_RS05100	COG2323	membrane
acear_RS05110	COG0187	DNA topoisomerase II activity
acear_RS05145	COG0437	4 iron, 4 sulfur cluster binding
acear_RS05150	COG2414	aldehyde ferredoxin oxidoreductase
acear_RS05170	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
acear_RS05180	COG1151	hydroxylamine reductase activity
acear_RS05185	COG0437	4 iron, 4 sulfur cluster binding
acear_RS05210	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
acear_RS05225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
acear_RS05240	COG2033	superoxide reductase activity
acear_RS05245	COG1592	Rubrerythrin
acear_RS05260	COG1752	Esterase of the alpha-beta hydrolase superfamily
acear_RS05265	COG3480	Lon protease (S16) C-terminal proteolytic domain
acear_RS05270	COG1323	Belongs to the UPF0348 family
acear_RS05275	COG0280	phosphate acetyltransferase
acear_RS05280	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
acear_RS05295	COG0534	Mate efflux family protein
acear_RS05300	COG0280	phosphate acetyltransferase
acear_RS05305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
acear_RS05315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
acear_RS05320	COG2030	dehydratase
acear_RS05330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
acear_RS05340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
acear_RS05345	COG1028	Short-chain dehydrogenase reductase Sdr
acear_RS05350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
acear_RS05360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
acear_RS05385	COG2081	HI0933 family
acear_RS05405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
acear_RS05410	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
acear_RS05420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
acear_RS05430	COG0204	Acyl-transferase
acear_RS05440	COG3279	Response regulator of the LytR AlgR family
acear_RS05445	COG1966	Carbon starvation protein
acear_RS05450	COG0539	negative regulation of cytoplasmic translation
acear_RS05450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
acear_RS05460	COG0860	N-Acetylmuramoyl-L-alanine amidase
acear_RS05490	COG1160	GTP binding
acear_RS05495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
acear_RS05500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
acear_RS05505	COG3835	regulator
acear_RS05510	COG5598	trimethylamine methyltransferase
acear_RS05515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
acear_RS05520	COG5012	cobalamin binding
acear_RS05525	COG5598	trimethylamine methyltransferase
acear_RS05530	COG5012	cobalamin binding
acear_RS05545	COG1410	methionine synthase
acear_RS05545	COG0646	methionine synthase
acear_RS05560	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
acear_RS05565	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
acear_RS05600	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
acear_RS05615	COG4492	Belongs to the UPF0735 family
acear_RS05620	COG0460	homoserine dehydrogenase
acear_RS05630	COG0083	homoserine kinase activity
acear_RS05635	COG0646	methionine synthase
acear_RS05635	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
acear_RS05650	COG2323	membrane
acear_RS05660	COG2094	Belongs to the DNA glycosylase MPG family
acear_RS05665	COG1827	regulation of RNA biosynthetic process
acear_RS05670	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
acear_RS05675	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
acear_RS05680	COG0157	Belongs to the NadC ModD family
acear_RS05700	COG1543	Belongs to the glycosyl hydrolase 57 family
acear_RS05705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
acear_RS05710	COG0297	glycogen (starch) synthase activity
acear_RS05720	COG1863	multisubunit Na H antiporter MnhE subunit
acear_RS05730	COG1320	monovalent cation:proton antiporter activity
acear_RS05745	COG1006	Multisubunit Na H antiporter MnhC subunit
acear_RS05750	COG0651	ATP synthesis coupled electron transport
acear_RS05755	COG0651	ATP synthesis coupled electron transport
acear_RS05760	COG0651	ATP synthesis coupled electron transport
acear_RS05775	COG1757	Na H antiporter
acear_RS05790	COG2217	Heavy metal translocating P-type atpase
acear_RS05800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
acear_RS05805	COG3404	Formiminotransferase-cyclodeaminase
acear_RS05820	COG2002	toxin-antitoxin pair type II binding
acear_RS05825	COG0640	Transcriptional regulator
acear_RS05835	COG3118	belongs to the thioredoxin family
acear_RS05840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
acear_RS05845	COG3409	Peptidoglycan-binding domain 1 protein
acear_RS05845	COG3773	Cell wall hydrolase
acear_RS05855	COG0860	N-Acetylmuramoyl-L-alanine amidase
acear_RS05880	COG0438	transferase activity, transferring glycosyl groups
acear_RS05890	COG1396	sequence-specific DNA binding
acear_RS05895	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
acear_RS05990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
acear_RS05995	COG0709	Synthesizes selenophosphate from selenide and ATP
acear_RS06015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
acear_RS06025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
acear_RS06035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
acear_RS06040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
acear_RS06045	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
acear_RS06050	COG0464	growth
acear_RS06055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
acear_RS06070	COG1923	regulation of RNA biosynthetic process
acear_RS06090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
acear_RS06100	COG2244	polysaccharide biosynthetic process
acear_RS06105	COG4974	Belongs to the 'phage' integrase family
acear_RS06110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
acear_RS06115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
acear_RS06120	COG0815	Transfers the fatty acyl group on membrane lipoproteins
acear_RS06125	COG1757	Na H antiporter
acear_RS06145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
acear_RS06160	COG3859	Proton-coupled thiamine transporter YuaJ
acear_RS06180	COG0514	ATP-dependent DNA helicase (RecQ)
acear_RS06185	COG0617	tRNA 3'-terminal CCA addition
acear_RS06205	COG0251	oxidation-reduction process
acear_RS06210	COG2964	Protein conserved in bacteria
acear_RS06220	COG1760	l-serine dehydratase
acear_RS06225	COG1760	l-serine dehydratase
acear_RS06240	COG3875	lactate racemase activity
acear_RS06290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
acear_RS06325	COG2323	membrane
acear_RS06335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
acear_RS06345	COG5012	cobalamin binding
acear_RS06350	COG5598	trimethylamine methyltransferase
acear_RS06360	COG1309	transcriptional regulator
acear_RS06370	COG2340	Cysteine-rich secretory protein family
acear_RS06380	COG0791	NLP P60 protein
acear_RS06380	COG1388	LysM domain
acear_RS06405	COG1051	belongs to the nudix hydrolase family
acear_RS06430	COG0328	RNA-DNA hybrid ribonuclease activity
acear_RS06440	COG0826	peptidase U32
acear_RS06470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
acear_RS06490	COG3976	FMN-binding domain protein
acear_RS06490	COG1053	succinate dehydrogenase
acear_RS06500	COG0326	Molecular chaperone. Has ATPase activity
acear_RS06510	COG1378	Sugar-specific transcriptional regulator TrmB
acear_RS06530	COG3344	reverse transcriptase
acear_RS06545	COG5002	protein histidine kinase activity
acear_RS06550	COG1067	ATP-dependent peptidase activity
acear_RS06575	COG5012	cobalamin binding
acear_RS06590	COG1525	nuclease
acear_RS06610	COG0456	acetyltransferase
acear_RS06615	COG1509	lysine 2,3-aminomutase activity
acear_RS06630	COG0301	tRNA thio-modification
acear_RS06635	COG1104	cysteine desulfurase activity
acear_RS06640	COG0011	TIGRFAM Protein of
acear_RS06650	COG0733	neurotransmitter:sodium symporter activity
acear_RS06660	COG1533	DNA photolyase activity
acear_RS06680	COG1363	Peptidase, m42
acear_RS06700	COG1615	UPF0182 protein
acear_RS06735	COG1151	hydroxylamine reductase activity
acear_RS06785	COG0028	Belongs to the TPP enzyme family
acear_RS06790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
acear_RS06795	COG1116	anion transmembrane transporter activity
acear_RS06800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
acear_RS06815	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
acear_RS06820	COG1331	Highly conserved protein containing a thioredoxin domain
acear_RS06840	COG0622	Phosphoesterase
acear_RS06850	COG0583	DNA-binding transcription factor activity
acear_RS06860	COG2201	protein-glutamate methylesterase activity
acear_RS06925	COG1573	uracil-dna glycosylase
acear_RS06940	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
acear_RS06950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
acear_RS06955	COG1073	alpha beta
acear_RS06960	COG2814	Major facilitator Superfamily
acear_RS06965	COG2707	UPF0756 membrane protein
acear_RS06970	COG2045	Belongs to the ComB family
acear_RS06975	COG1809	phosphosulfolactate synthase activity
acear_RS06985	COG1397	ADP-ribosylglycohydrolase
acear_RS06990	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
acear_RS06995	COG3842	ATPase activity
acear_RS07000	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
acear_RS07005	COG0725	ABC transporter, periplasmic molybdate-binding protein
acear_RS07015	COG3585	molybdate ion transport
acear_RS07025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
acear_RS07035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
acear_RS07040	COG0569	domain protein
acear_RS07075	COG2323	membrane
acear_RS07080	COG1131	(ABC) transporter
acear_RS07085	COG0842	Transport permease protein
acear_RS07100	COG0569	domain protein
acear_RS07100	COG0475	glutathione-regulated potassium exporter activity
acear_RS07105	COG0569	domain protein
acear_RS07110	COG2204	response regulator
acear_RS07115	COG0745	RESPONSE REGULATOR receiver
acear_RS07120	COG5002	protein histidine kinase activity
acear_RS07175	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
acear_RS07205	COG1404	Belongs to the peptidase S8 family
acear_RS07210	COG0464	growth
acear_RS07225	COG1473	amidohydrolase
acear_RS07230	COG4145	pantothenate transmembrane transporter activity
acear_RS07245	COG0483	inositol monophosphate 1-phosphatase activity
acear_RS07250	COG0484	heat shock protein binding
acear_RS07260	COG3314	Sporulation integral membrane protein YlbJ
acear_RS07270	COG3264	Mechanosensitive ion channel
acear_RS07270	COG1511	domain protein
acear_RS07275	COG2364	Membrane
acear_RS07285	COG0628	permease
acear_RS07290	COG0602	queuosine metabolic process
acear_RS07295	COG0720	synthase
acear_RS07300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
acear_RS07305	COG1924	4 iron, 4 sulfur cluster binding
acear_RS07330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
acear_RS07335	COG0742	ribosomal rna small subunit methyltransferase
acear_RS07340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
acear_RS07345	COG1307	EDD domain protein, DegV family
acear_RS07350	COG1461	Dihydroxyacetone kinase
acear_RS07355	COG1302	Protein conserved in bacteria
acear_RS07365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
acear_RS07370	COG0281	malic enzyme
acear_RS07380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
acear_RS07385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
acear_RS07390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
acear_RS07390	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
acear_RS07400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
acear_RS07400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
acear_RS07405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
acear_RS07410	COG1162	GTPase activity
acear_RS07415	COG0515	serine threonine protein kinase
acear_RS07415	COG2815	serine threonine protein kinase
acear_RS07420	COG0631	protein serine/threonine phosphatase activity
acear_RS07425	COG0820	rRNA (adenine-C2-)-methyltransferase activity
acear_RS07430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
acear_RS07430	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
acear_RS07440	COG2738	Putative neutral zinc metallopeptidase
acear_RS07450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
acear_RS07455	COG0242	peptide deformylase activity
acear_RS07460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
acear_RS07465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
acear_RS07470	COG1122	ATPase activity
acear_RS07475	COG4120	Belongs to the binding-protein-dependent transport system permease family
acear_RS07485	COG1854	S-ribosylhomocysteine lyase activity
acear_RS07490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
acear_RS07495	COG1758	RNA polymerase activity
acear_RS07500	COG0194	GDP metabolic process
acear_RS07510	COG1561	YicC-like family, N-terminal region
acear_RS07520	COG0107	imidazoleglycerol-phosphate synthase activity
acear_RS07525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
acear_RS07530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
acear_RS07535	COG0131	Imidazoleglycerol-phosphate dehydratase
acear_RS07540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
acear_RS07545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
acear_RS07550	COG0124	histidyl-tRNA synthetase
acear_RS07555	COG3773	Cell wall hydrolase
acear_RS07560	COG0105	UTP biosynthetic process
acear_RS07565	COG1196	nuclear chromosome segregation
acear_RS07580	COG0848	biopolymer transport protein
acear_RS07585	COG0811	peptide transport
acear_RS07590	COG0587	DNA-directed DNA polymerase activity
acear_RS07595	COG0700	Nucleoside recognition
acear_RS07600	COG2715	membrane protein required for spore maturation
acear_RS07605	COG2359	stage V sporulation protein S
acear_RS07610	COG1692	metallophosphoesterase
acear_RS07615	COG1418	mRNA catabolic process
acear_RS07640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
acear_RS07655	COG1546	Belongs to the CinA family
acear_RS07655	COG1058	Belongs to the CinA family
acear_RS07665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
acear_RS07680	COG2414	aldehyde ferredoxin oxidoreductase
acear_RS07705	COG3314	Sporulation integral membrane protein YlbJ
acear_RS07710	COG0371	Dehydrogenase
acear_RS07715	COG0436	Aminotransferase
acear_RS07720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
acear_RS07725	COG0517	IMP dehydrogenase activity
acear_RS07730	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
acear_RS07735	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
acear_RS07740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
acear_RS07760	COG1597	lipid kinase activity
acear_RS07775	COG0612	Peptidase, M16
acear_RS07825	COG2414	aldehyde ferredoxin oxidoreductase
acear_RS07835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
acear_RS07845	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
acear_RS07850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
acear_RS07855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
acear_RS07865	COG0302	gtp cyclohydrolase
acear_RS07890	COG0165	Argininosuccinate lyase
acear_RS07900	COG0137	argininosuccinate synthase activity
acear_RS07905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
acear_RS07910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
acear_RS07915	COG0505	Belongs to the CarA family
acear_RS07930	COG2323	membrane
acear_RS07945	COG1121	(ABC) transporter
acear_RS07950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
acear_RS07955	COG0697	spore germination
acear_RS07960	COG0531	amino acid
acear_RS07965	COG0531	amino acid
acear_RS07985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
acear_RS07990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
acear_RS07995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
acear_RS08000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
acear_RS08005	COG1278	Cold shock
acear_RS08015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
acear_RS08035	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
acear_RS08060	COG1968	undecaprenyl-diphosphatase activity
acear_RS08065	COG3331	DNA recombination
acear_RS08070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
acear_RS08075	COG2155	Conserved Protein
acear_RS08085	COG1674	ftsk spoiiie
acear_RS08090	COG1283	sodium-dependent phosphate transmembrane transporter activity
acear_RS08095	COG1283	sodium-dependent phosphate transmembrane transporter activity
acear_RS08105	COG0740	serine-type endopeptidase activity
acear_RS08115	COG2022	thiamine diphosphate biosynthetic process
acear_RS08120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
acear_RS08125	COG0352	thiamine-phosphate diphosphorylase activity
acear_RS08130	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
acear_RS08135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
acear_RS08140	COG0527	aspartate kinase activity
acear_RS08145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
acear_RS08150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
acear_RS08155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
acear_RS08160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
acear_RS08170	COG1873	PFAM PRC-barrel domain
acear_RS08175	COG0756	dUTP diphosphatase activity
acear_RS08180	COG2720	vancomycin resistance protein
acear_RS08185	COG0726	polysaccharide deacetylase
acear_RS08190	COG0726	polysaccharide deacetylase
acear_RS08200	COG3773	Cell wall hydrolase
acear_RS08200	COG3409	Peptidoglycan-binding domain 1 protein
acear_RS08205	COG1199	ATP-dependent helicase activity
acear_RS08210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
acear_RS08215	COG1185	polyribonucleotide nucleotidyltransferase activity
acear_RS08220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
acear_RS08225	COG0196	riboflavin kinase activity
acear_RS08230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
acear_RS08235	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
acear_RS08240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
acear_RS08245	COG0195	Participates in both transcription termination and antitermination
acear_RS08250	COG0779	Required for maturation of 30S ribosomal subunits
acear_RS08260	COG1285	pathogenesis
acear_RS08270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
acear_RS08275	COG1418	mRNA catabolic process
acear_RS08280	COG0750	zinc metalloprotease
acear_RS08285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
acear_RS08295	COG4589	Belongs to the CDS family
acear_RS08305	COG0233	cytoplasmic translational termination
acear_RS08310	COG0528	UMP kinase activity
acear_RS08315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
acear_RS08320	COG0052	Belongs to the universal ribosomal protein uS2 family
acear_RS08345	COG1191	sigma factor activity
acear_RS08355	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
acear_RS08360	COG1776	CheC inhibitor of MCP methylation
acear_RS08375	COG1419	protein localization to endoplasmic reticulum
acear_RS08380	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
acear_RS08385	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
acear_RS08390	COG1684	flagellar biosynthetic protein fliR
acear_RS08395	COG1987	bacterial-type flagellum assembly
acear_RS08400	COG1338	Plays a role in the flagellum-specific transport system
acear_RS08410	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
acear_RS08410	COG1776	CheC inhibitor of MCP methylation
acear_RS08415	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
acear_RS08425	COG1360	Flagellar Motor Protein
acear_RS08450	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
acear_RS08455	COG3144	bacterial-type flagellum assembly
acear_RS08470	COG1157	protein secretion by the type III secretion system
acear_RS08480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
acear_RS08485	COG1766	The M ring may be actively involved in energy transduction
acear_RS08490	COG1677	Flagellar hook-basal body complex protein FliE
acear_RS08500	COG1815	bacterial-type flagellum-dependent cell motility
acear_RS08510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
acear_RS08515	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
acear_RS08520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
acear_RS08530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
acear_RS08530	COG0758	DNA mediated transformation
acear_RS08535	COG0606	chelatase, subunit chli
acear_RS08540	COG0792	nuclease activity
acear_RS08550	COG0393	Putative heavy-metal-binding
acear_RS08560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
acear_RS08565	COG0681	Belongs to the peptidase S26 family
acear_RS08570	COG0335	large ribosomal subunit rRNA binding
acear_RS08575	COG4752	Belongs to the RNA methyltransferase TrmD family
acear_RS08580	COG0336	Belongs to the RNA methyltransferase TrmD family
acear_RS08585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
acear_RS08595	COG0228	four-way junction DNA binding
acear_RS08600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
acear_RS08605	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
acear_RS08610	COG0552	protein localization to endoplasmic reticulum
acear_RS08620	COG1196	nuclear chromosome segregation
acear_RS08625	COG2359	stage V sporulation protein S
acear_RS08635	COG1187	pseudouridine synthase activity
acear_RS08640	COG1686	Belongs to the peptidase S11 family
acear_RS08645	COG3874	Sporulation protein YtfJ
acear_RS08670	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
acear_RS08675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
acear_RS08680	COG0180	Tryptophanyl-tRNA synthetase
acear_RS08685	COG1994	Peptidase M50
acear_RS08690	COG3620	sequence-specific DNA binding
acear_RS08690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
acear_RS08690	COG0617	tRNA 3'-terminal CCA addition
acear_RS08695	COG0019	diaminopimelate decarboxylase activity
acear_RS08700	COG1254	Belongs to the acylphosphatase family
acear_RS08705	COG1309	transcriptional regulator
acear_RS08715	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
acear_RS08720	COG2409	Drug exporters of the RND superfamily
acear_RS08745	COG0697	spore germination
acear_RS08760	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
acear_RS08780	COG2172	sigma factor antagonist activity
acear_RS08790	COG1686	Belongs to the peptidase S11 family
acear_RS08795	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
acear_RS08805	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
acear_RS08810	COG1300	Membrane
acear_RS08830	COG2195	Cleaves the N-terminal amino acid of tripeptides
acear_RS08835	COG3457	Alanine racemase
acear_RS08840	COG5012	cobalamin binding
acear_RS08855	COG0733	neurotransmitter:sodium symporter activity
acear_RS08865	COG1215	transferase activity, transferring glycosyl groups
acear_RS08880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
acear_RS08885	COG0745	RESPONSE REGULATOR receiver
acear_RS08890	COG0750	zinc metalloprotease
acear_RS08895	COG0497	DNA recombination
acear_RS08900	COG1438	arginine binding
acear_RS08905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
acear_RS08910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
acear_RS08915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
acear_RS08925	COG1722	exodeoxyribonuclease VII activity
acear_RS08930	COG1570	exodeoxyribonuclease VII activity
acear_RS08935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
acear_RS08940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
acear_RS08945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
acear_RS08960	COG1302	Protein conserved in bacteria
acear_RS08965	COG0439	Biotin carboxylase
acear_RS09010	COG3854	ATPases associated with a variety of cellular activities
acear_RS09015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
acear_RS09020	COG0006	proline dipeptidase activity
acear_RS09030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
acear_RS09035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
acear_RS09040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
acear_RS09065	COG0849	cell division
acear_RS09090	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
acear_RS09105	COG4969	Belongs to the N-Me-Phe pilin family
acear_RS09110	COG1459	type II secretion system
acear_RS09120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
acear_RS09125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
acear_RS09135	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
acear_RS09145	COG1918	ferrous iron import across plasma membrane
acear_RS09145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
acear_RS09150	COG0735	belongs to the Fur family
acear_RS09155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
acear_RS09165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
acear_RS09170	COG1418	mRNA catabolic process
acear_RS09180	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
acear_RS09185	COG0492	ferredoxin-NADP+ reductase activity
acear_RS09190	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
acear_RS09200	COG1342	Belongs to the UPF0251 family
acear_RS09210	COG0489	protein tyrosine kinase activity
acear_RS09235	COG0735	belongs to the Fur family
acear_RS09240	COG2186	Transcriptional regulator
acear_RS09245	COG3875	lactate racemase activity
acear_RS09250	COG0247	lactate metabolic process
acear_RS09255	COG0277	FAD linked oxidase domain protein
acear_RS09260	COG1620	l-lactate permease
acear_RS09265	COG2186	Transcriptional regulator
acear_RS09270	COG0277	FAD linked oxidase domain protein
acear_RS09275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
acear_RS09310	COG0516	GMP reductase activity
acear_RS09310	COG0517	IMP dehydrogenase activity
acear_RS09320	COG0791	NLP P60 protein
acear_RS09320	COG1388	LysM domain
acear_RS09325	COG0166	Belongs to the GPI family
acear_RS09350	COG0123	including yeast histone deacetylase and acetoin utilization protein
acear_RS09375	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
acear_RS09375	COG0493	'glutamate synthase
acear_RS09380	COG0069	glutamate synthase activity
acear_RS09385	COG0067	glutamate synthase
acear_RS09390	COG0347	Belongs to the P(II) protein family
acear_RS09395	COG0004	ammonium transporteR
acear_RS09405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
acear_RS09410	COG0367	asparagine synthase
acear_RS09415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
acear_RS09425	COG3829	transcription factor binding
acear_RS09425	COG3290	protein histidine kinase activity
acear_RS09430	COG2031	fatty acid transporter
acear_RS09435	COG0183	Belongs to the thiolase family
acear_RS09445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
acear_RS09455	COG0534	Mate efflux family protein
acear_RS09465	COG1388	LysM domain
acear_RS09485	COG0534	Mate efflux family protein
acear_RS09495	COG1566	PFAM secretion protein HlyD family protein
acear_RS09510	COG5598	trimethylamine methyltransferase
acear_RS09525	COG0436	Aminotransferase
acear_RS09530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
acear_RS09540	COG0205	6-phosphofructokinase activity
acear_RS09545	COG0825	malonyl-CoA metabolic process
acear_RS09550	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
acear_RS09560	COG0159	tryptophan synthase activity
acear_RS09565	COG0133	tryptophan synthase activity
acear_RS09575	COG0134	indole-3-glycerol-phosphate synthase activity
acear_RS09580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
acear_RS09590	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
acear_RS09605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
acear_RS09630	COG1217	gtp-binding protein TYPA
acear_RS09635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
acear_RS09640	COG0432	Pfam Uncharacterised protein family UPF0047
acear_RS09645	COG1584	GPR1 FUN34 yaaH family protein
acear_RS09660	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
acear_RS09665	COG0735	belongs to the Fur family
acear_RS09670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
acear_RS09685	COG0318	PFAM AMP-dependent synthetase and ligase
acear_RS09690	COG2032	superoxide dismutase activity
acear_RS09700	COG1278	Cold shock
acear_RS09705	COG1278	Cold shock
acear_RS09715	COG0674	pyruvate-flavodoxin oxidoreductase activity
acear_RS09740	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
acear_RS09745	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
acear_RS09750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
acear_RS09755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
acear_RS09760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
acear_RS09765	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
acear_RS09775	COG1192	Involved in chromosome partitioning
acear_RS09795	COG5002	protein histidine kinase activity
acear_RS09805	COG3385	transposase activity
acear_RS09820	COG5002	protein histidine kinase activity
acear_RS09825	COG0745	RESPONSE REGULATOR receiver
acear_RS09830	COG0577	efflux transmembrane transporter activity
acear_RS09830	COG1136	(ABC) transporter
acear_RS09835	COG1136	(ABC) transporter
acear_RS09860	COG0534	Mate efflux family protein
acear_RS09865	COG0129	dihydroxy-acid dehydratase activity
acear_RS09870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
acear_RS09875	COG2610	gluconate transmembrane transporter activity
acear_RS09885	COG3385	transposase activity
acear_RS09905	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
acear_RS09905	COG2199	diguanylate cyclase activity
acear_RS09920	COG1473	amidohydrolase
acear_RS09925	COG2986	histidine ammonia-lyase
acear_RS09930	COG1288	antiporter activity
acear_RS09935	COG1672	PFAM Archaeal ATPase
acear_RS09935	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
acear_RS09955	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
acear_RS09980	COG0697	spore germination
acear_RS09985	COG0697	spore germination
acear_RS10005	COG0175	sulfate reduction
acear_RS10020	COG2217	Heavy metal translocating P-type atpase
acear_RS10025	COG0785	Cytochrome C biogenesis protein
acear_RS10040	COG0482	sulfurtransferase activity
acear_RS10045	COG1959	2 iron, 2 sulfur cluster binding
acear_RS10050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
acear_RS10055	COG1454	alcohol dehydrogenase
acear_RS10055	COG1012	belongs to the aldehyde dehydrogenase family
acear_RS10065	COG0644	oxidoreductase
acear_RS10100	COG0668	transmembrane transport
acear_RS10105	COG0789	Transcriptional regulator
acear_RS10125	COG2703	oxygen carrier activity
acear_RS10130	COG1278	Cold shock
acear_RS10140	COG1404	Belongs to the peptidase S8 family
acear_RS10175	COG5002	protein histidine kinase activity
acear_RS10175	COG5001	Diguanylate cyclase
acear_RS10175	COG3447	MASE1 domain protein
acear_RS10200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
acear_RS10240	COG1063	alcohol dehydrogenase
acear_RS10250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
acear_RS10270	COG2201	protein-glutamate methylesterase activity
acear_RS10275	COG0719	Fe-S assembly protein
acear_RS10280	COG1137	ATPase activity
acear_RS10295	COG0640	Transcriptional regulator
acear_RS10310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
acear_RS10315	COG0640	Transcriptional regulator
acear_RS10320	COG0798	PFAM Bile acid sodium symporter
acear_RS10360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
acear_RS10395	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
acear_RS10400	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
acear_RS10405	COG0352	thiamine-phosphate diphosphorylase activity
acear_RS10410	COG0351	phosphomethylpyrimidine kinase
acear_RS10410	COG0352	thiamine-phosphate diphosphorylase activity
acear_RS10415	COG1049	propionate catabolic process, 2-methylcitrate cycle
acear_RS10420	COG0446	pyridine nucleotide-disulphide oxidoreductase
acear_RS10430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
acear_RS10435	COG0473	3-isopropylmalate dehydrogenase activity
acear_RS10440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
acear_RS10445	COG0154	amidase activity
acear_RS10450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
acear_RS10455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
acear_RS10470	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
acear_RS10475	COG2339	peptidase activity
acear_RS10485	COG0529	Catalyzes the synthesis of activated sulfate
acear_RS10490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
acear_RS10495	COG1464	Belongs to the NlpA lipoprotein family
acear_RS10500	COG2011	ABC-type metal ion transport system permease component
acear_RS10505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
acear_RS10515	COG4496	protein, YerC YecD
acear_RS10520	COG0521	Mo-molybdopterin cofactor biosynthetic process
acear_RS10530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
acear_RS10535	COG0303	'Molybdopterin
acear_RS10540	COG0303	'Molybdopterin
acear_RS10550	COG2252	PERMEase
acear_RS10580	COG0697	spore germination
acear_RS10585	COG0459	protein refolding
acear_RS10590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
acear_RS10595	COG3830	Belongs to the UPF0237 family
acear_RS10600	COG2848	UPF0210 protein
acear_RS10610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
acear_RS10620	COG1214	PFAM Peptidase M22, glycoprotease
acear_RS10625	COG0802	atpase or kinase
acear_RS10640	COG1473	amidohydrolase
acear_RS10645	COG2337	Toxic component of a toxin-antitoxin (TA) module
acear_RS10660	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
acear_RS10665	COG0517	IMP dehydrogenase activity
acear_RS10670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
acear_RS10670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
acear_RS10675	COG0736	holo-[acyl-carrier-protein] synthase activity
acear_RS10690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
acear_RS10695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
acear_RS10700	COG0179	Fumarylacetoacetate (FAA) hydrolase
acear_RS10705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
acear_RS10715	COG1396	sequence-specific DNA binding
acear_RS10725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
acear_RS10730	COG0110	maltose O-acetyltransferase activity
acear_RS10735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
acear_RS10755	COG3385	transposase activity
acear_RS10825	COG0529	Catalyzes the synthesis of activated sulfate
acear_RS10825	COG2895	sulfate adenylyltransferase (ATP) activity
acear_RS10840	COG0175	sulfate reduction
acear_RS10845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
acear_RS10850	COG4464	protein tyrosine phosphatase activity
acear_RS10855	COG0489	protein tyrosine kinase activity
acear_RS10860	COG3944	biosynthesis protein
acear_RS10865	COG1596	polysaccharide export
acear_RS10865	COG1555	photosystem II stabilization
acear_RS10875	COG1482	cell wall glycoprotein biosynthetic process
acear_RS10880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
acear_RS10890	COG0463	Glycosyl transferase, family 2
acear_RS10915	COG0438	transferase activity, transferring glycosyl groups
acear_RS10950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
acear_RS10955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
acear_RS10960	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
acear_RS10965	COG0438	transferase activity, transferring glycosyl groups
acear_RS10975	COG0438	transferase activity, transferring glycosyl groups
acear_RS11010	COG0859	PFAM glycosyl transferase family 9
acear_RS11015	COG0859	PFAM glycosyl transferase family 9
acear_RS11020	COG1519	Transferase
acear_RS11040	COG3206	protein involved in exopolysaccharide biosynthesis
acear_RS11050	COG4372	Transposase
acear_RS11060	COG1137	ATPase activity
acear_RS11080	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
acear_RS11090	COG2877	3-deoxy-8-phosphooctulonate synthase activity
acear_RS11100	COG1663	tetraacyldisaccharide 4'-kinase activity
acear_RS11110	COG1132	(ABC) transporter
acear_RS11115	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
acear_RS11125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
acear_RS11130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
acear_RS11135	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
acear_RS11155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
acear_RS11195	COG1706	bacterial-type flagellum-dependent cell motility
acear_RS11200	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
acear_RS11215	COG4786	Flagellar basal body rod
acear_RS11220	COG1609	Transcriptional regulator
acear_RS11230	COG2385	sporulation resulting in formation of a cellular spore
acear_RS11235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
acear_RS11240	COG5506	Protein of unknown function (DUF1694)
acear_RS11245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
acear_RS11250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
acear_RS11255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
acear_RS11260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
acear_RS11265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
acear_RS11270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
acear_RS11300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
acear_RS11305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
acear_RS11315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
acear_RS11320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
acear_RS11325	COG0698	ribose 5-phosphate isomerase
acear_RS11330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
acear_RS11335	COG0009	L-threonylcarbamoyladenylate synthase
acear_RS11340	COG2890	protein-(glutamine-N5) methyltransferase activity
acear_RS11345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
acear_RS11350	COG3872	metal-dependent enzyme
acear_RS11355	COG0254	rRNA binding
acear_RS11360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
acear_RS11365	COG0191	fructose-bisphosphate aldolase activity
acear_RS11380	COG0504	CTP synthase activity
acear_RS11385	COG0018	arginyl-trna synthetase
acear_RS11395	COG2707	UPF0756 membrane protein
acear_RS11425	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
acear_RS11435	COG4753	response regulator
acear_RS11435	COG2207	Transcriptional regulator
acear_RS11440	COG3275	phosphorelay sensor kinase activity
acear_RS11445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
acear_RS11450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
acear_RS11455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
acear_RS11460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
acear_RS11465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
acear_RS11485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
acear_RS11490	COG0530	calcium, potassium:sodium antiporter activity
acear_RS11500	COG1309	transcriptional regulator
acear_RS11525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
acear_RS11560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
acear_RS11595	COG1921	L-seryl-tRNASec selenium transferase activity
acear_RS11600	COG1924	4 iron, 4 sulfur cluster binding
acear_RS11605	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
acear_RS11610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
acear_RS11615	COG1126	abc transporter atp-binding protein
acear_RS11630	COG2897	thiosulfate sulfurtransferase activity
acear_RS11660	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
acear_RS11670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
acear_RS11675	COG3383	formate dehydrogenase (NAD+) activity
acear_RS11680	COG3383	formate dehydrogenase (NAD+) activity
acear_RS11685	COG1034	ATP synthesis coupled electron transport
acear_RS11705	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
acear_RS11725	COG0512	Glutamine amidotransferase of anthranilate synthase
acear_RS11740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
acear_RS11745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
acear_RS11750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
acear_RS11760	COG0047	phosphoribosylformylglycinamidine synthase activity
acear_RS11765	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
acear_RS11770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
acear_RS11775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
acear_RS11780	COG1752	Esterase of the alpha-beta hydrolase superfamily
acear_RS11785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
acear_RS11790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
acear_RS11795	COG0151	Belongs to the GarS family
acear_RS11800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
acear_RS11805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
acear_RS11810	COG0305	Participates in initiation and elongation during chromosome replication
acear_RS11820	COG0359	binds to the 23S rRNA
acear_RS11825	COG4241	membrane
acear_RS11835	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
acear_RS11840	COG0629	single-stranded DNA binding
acear_RS11845	COG0360	Binds together with S18 to 16S ribosomal RNA
acear_RS11850	COG0012	GTP binding
acear_RS11855	COG4481	Protein conserved in bacteria
acear_RS11860	COG3949	Membrane
acear_RS11875	COG1811	Na channel or pump
acear_RS11880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
acear_RS11885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
acear_RS11900	COG1475	DNA binding
acear_RS11905	COG1192	Involved in chromosome partitioning
acear_RS11910	COG1475	DNA binding
acear_RS11920	COG0357	Ribosomal RNA small subunit methyltransferase G
acear_RS11925	COG0445	tRNA wobble uridine modification
acear_RS11930	COG0445	tRNA wobble uridine modification
acear_RS11935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
acear_RS11940	COG1847	R3H domain protein
acear_RS11945	COG0706	membrane insertase activity
acear_RS11950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
acear_RS11955	COG0594	ribonuclease P activity
acear_RS11970	COG2340	Cysteine-rich secretory protein family
acear_RS11980	COG2720	vancomycin resistance protein
acear_RS12000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
acear_RS12030	COG0791	NLP P60 protein
acear_RS12030	COG1388	LysM domain
acear_RS12045	COG0850	regulation of cytokinetic process
acear_RS12075	COG0328	RNA-DNA hybrid ribonuclease activity
acear_RS12105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
acear_RS12140	COG0739	heme binding
acear_RS12185	COG1426	Protein conserved in bacteria
acear_RS12190	COG1388	LysM domain
acear_RS12190	COG3584	3D domain protein
acear_RS12195	COG0860	N-Acetylmuramoyl-L-alanine amidase
acear_RS12205	COG0860	N-Acetylmuramoyl-L-alanine amidase
acear_RS12205	COG2247	cell wall binding repeat
acear_RS12215	COG1309	transcriptional regulator
acear_RS12230	COG0463	Glycosyl transferase, family 2
acear_RS12230	COG1216	Glycosyl transferase, family 2