locus-tag	class	description
BN853_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BN853_RS00010	COG0592	DNA-directed DNA polymerase activity
BN853_RS00015	COG2501	S4 domain
BN853_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BN853_RS00025	COG0187	DNA topoisomerase II activity
BN853_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BN853_RS00035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BN853_RS00040	COG0745	RESPONSE REGULATOR receiver
BN853_RS00045	COG2205	protein histidine kinase activity
BN853_RS00045	COG2770	Histidine kinase
BN853_RS00050	COG0537	adenosine 5'-monophosphoramidase activity
BN853_RS00055	COG4869	propanediol catabolic process
BN853_RS00060	COG1078	dGTPase activity
BN853_RS00065	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BN853_RS00070	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BN853_RS00075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BN853_RS00090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BN853_RS00110	COG0420	3'-5' exonuclease activity
BN853_RS00115	COG0419	ATPase involved in DNA repair
BN853_RS00120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BN853_RS00130	COG0668	transmembrane transport
BN853_RS00135	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BN853_RS00140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BN853_RS00145	COG1086	Polysaccharide biosynthesis protein
BN853_RS00150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BN853_RS00155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BN853_RS00160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BN853_RS00165	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BN853_RS00175	COG0095	Lipoate-protein ligase
BN853_RS00180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BN853_RS00185	COG0509	glycine decarboxylation via glycine cleavage system
BN853_RS00190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BN853_RS00195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BN853_RS00200	COG0579	oxidoreductase
BN853_RS00205	COG0492	ferredoxin-NADP+ reductase activity
BN853_RS00225	COG0133	tryptophan synthase activity
BN853_RS00235	COG4221	oxidoreductase activity
BN853_RS00255	COG3437	response regulator, receiver
BN853_RS00280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BN853_RS00330	COG0579	oxidoreductase
BN853_RS00335	COG0492	ferredoxin-NADP+ reductase activity
BN853_RS00345	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BN853_RS00350	COG4974	Belongs to the 'phage' integrase family
BN853_RS00355	COG4974	Belongs to the 'phage' integrase family
BN853_RS00370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BN853_RS00375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BN853_RS00385	COG0438	transferase activity, transferring glycosyl groups
BN853_RS00405	COG0438	transferase activity, transferring glycosyl groups
BN853_RS00420	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BN853_RS00430	COG1070	Carbohydrate kinase
BN853_RS00435	COG4806	L-rhamnose isomerase
BN853_RS00440	COG0235	Class ii aldolase
BN853_RS00455	COG1175	transmembrane transport
BN853_RS00465	COG0395	ABC-type sugar transport system, permease component
BN853_RS00525	COG1131	(ABC) transporter
BN853_RS00530	COG1131	(ABC) transporter
BN853_RS00540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BN853_RS00545	COG0438	transferase activity, transferring glycosyl groups
BN853_RS00565	COG0726	polysaccharide deacetylase
BN853_RS00575	COG2348	transferase activity, transferring amino-acyl groups
BN853_RS00580	COG0728	peptidoglycan biosynthetic process
BN853_RS00585	COG0438	transferase activity, transferring glycosyl groups
BN853_RS00625	COG0577	efflux transmembrane transporter activity
BN853_RS00625	COG1136	(ABC) transporter
BN853_RS00630	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BN853_RS00675	COG2801	Transposase and inactivated derivatives
BN853_RS00700	COG0516	GMP reductase activity
BN853_RS00700	COG0517	IMP dehydrogenase activity
BN853_RS00705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BN853_RS00705	COG0519	Catalyzes the synthesis of GMP from XMP
BN853_RS00740	COG0483	inositol monophosphate 1-phosphatase activity
BN853_RS00745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BN853_RS00790	COG1104	cysteine desulfurase activity
BN853_RS00795	COG0174	glutamine synthetase
BN853_RS00800	COG2207	Transcriptional regulator
BN853_RS00800	COG4753	response regulator
BN853_RS00805	COG2972	Histidine kinase
BN853_RS00820	COG1129	ABC transporter
BN853_RS00825	COG4211	Belongs to the binding-protein-dependent transport system permease family
BN853_RS00845	COG0492	ferredoxin-NADP+ reductase activity
BN853_RS00850	COG1882	Formate acetyltransferase
BN853_RS00855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BN853_RS00860	COG0534	Mate efflux family protein
BN853_RS00865	COG1609	Transcriptional regulator
BN853_RS00875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BN853_RS00885	COG3069	C4-dicarboxylate transmembrane transporter activity
BN853_RS00890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BN853_RS00905	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BN853_RS00910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BN853_RS00915	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BN853_RS00925	COG2252	PERMEase
BN853_RS00935	COG0217	transcriptional regulatory protein
BN853_RS00945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BN853_RS00950	COG4656	Part of a membrane complex involved in electron transport
BN853_RS00975	COG4657	Part of a membrane complex involved in electron transport
BN853_RS00985	COG1245	4Fe-4S binding domain
BN853_RS00985	COG2878	Part of a membrane complex involved in electron transport
BN853_RS01010	COG1435	thymidine kinase activity
BN853_RS01015	COG0590	tRNA wobble adenosine to inosine editing
BN853_RS01020	COG1805	sodium ion transport
BN853_RS01030	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BN853_RS01050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BN853_RS01055	COG0445	tRNA wobble uridine modification
BN853_RS01060	COG0357	Ribosomal RNA small subunit methyltransferase G
BN853_RS01065	COG1192	Involved in chromosome partitioning
BN853_RS01070	COG1475	DNA binding
BN853_RS01195	COG1846	Transcriptional regulator
BN853_RS01200	COG1940	carbohydrate kinase activity
BN853_RS01205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BN853_RS01210	COG0051	transcription antitermination factor activity, RNA binding
BN853_RS01215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BN853_RS01220	COG0088	Forms part of the polypeptide exit tunnel
BN853_RS01225	COG0089	rRNA binding
BN853_RS01230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BN853_RS01240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BN853_RS01250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BN853_RS01255	COG0255	Belongs to the universal ribosomal protein uL29 family
BN853_RS01260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BN853_RS01265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BN853_RS01270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BN853_RS01280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BN853_RS01285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BN853_RS01295	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BN853_RS01300	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BN853_RS01305	COG1841	ribosomal large subunit assembly
BN853_RS01310	COG0200	Binds to the 23S rRNA
BN853_RS01315	COG0201	protein transport
BN853_RS01320	COG0563	adenylate kinase activity
BN853_RS01325	COG0024	Methionine aminopeptidase
BN853_RS01330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BN853_RS01335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BN853_RS01340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BN853_RS01345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BN853_RS01350	COG0202	RNA polymerase activity
BN853_RS01355	COG0203	ribosomal protein L17
BN853_RS01365	COG0346	lactoylglutathione lyase activity
BN853_RS01370	COG1846	Transcriptional regulator
BN853_RS01375	COG0492	ferredoxin-NADP+ reductase activity
BN853_RS01395	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BN853_RS01400	COG0101	tRNA pseudouridine synthase activity
BN853_RS01405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BN853_RS01410	COG0470	DNA polymerase III
BN853_RS01415	COG1774	PSP1 C-terminal conserved region
BN853_RS01420	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BN853_RS01430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BN853_RS01440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BN853_RS01445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BN853_RS01450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BN853_RS01465	COG1175	transmembrane transport
BN853_RS01470	COG0395	ABC-type sugar transport system, permease component
BN853_RS01495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BN853_RS01510	COG0215	cysteine-tRNA ligase activity
BN853_RS01515	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BN853_RS01520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BN853_RS01525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BN853_RS01535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BN853_RS01545	COG0250	Participates in transcription elongation, termination and antitermination
BN853_RS01555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BN853_RS01565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BN853_RS01570	COG0222	ribosome binding
BN853_RS01575	COG2813	Specifically methylates the guanine in position
BN853_RS01585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BN853_RS01590	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BN853_RS01595	COG0049	tRNA binding
BN853_RS01600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BN853_RS01605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BN853_RS01610	COG0084	hydrolase, TatD family'
BN853_RS01615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BN853_RS01630	COG0360	Binds together with S18 to 16S ribosomal RNA
BN853_RS01635	COG0629	single-stranded DNA binding
BN853_RS01640	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BN853_RS01645	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BN853_RS01645	COG0359	binds to the 23S rRNA
BN853_RS01650	COG0305	Participates in initiation and elongation during chromosome replication
BN853_RS01655	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BN853_RS01660	COG2890	protein-(glutamine-N5) methyltransferase activity
BN853_RS01665	COG0009	L-threonylcarbamoyladenylate synthase
BN853_RS01670	COG2801	Transposase and inactivated derivatives
BN853_RS01685	COG1217	gtp-binding protein TYPA
BN853_RS01690	COG0698	ribose 5-phosphate isomerase
BN853_RS01695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BN853_RS01705	COG1739	Uncharacterized protein family UPF0029
BN853_RS01735	COG0617	tRNA 3'-terminal CCA addition
BN853_RS01740	COG1523	belongs to the glycosyl hydrolase 13 family
BN853_RS01745	COG3481	metal-dependent phosphohydrolase, HD sub domain
BN853_RS01755	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BN853_RS01760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BN853_RS01770	COG1970	mechanosensitive ion channel activity
BN853_RS01780	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BN853_RS01790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BN853_RS01795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BN853_RS01805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BN853_RS01810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BN853_RS01820	COG0416	fatty acid biosynthetic process
BN853_RS01825	COG0571	ribonuclease III activity
BN853_RS01835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BN853_RS01850	COG0439	Biotin carboxylase
BN853_RS01855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BN853_RS01865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BN853_RS01875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BN853_RS01880	COG1028	Short-chain dehydrogenase reductase Sdr
BN853_RS01885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BN853_RS01890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BN853_RS01895	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BN853_RS01895	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BN853_RS01900	COG1268	BioY protein
BN853_RS01905	COG2070	2-Nitropropane dioxygenase
BN853_RS01920	COG2086	electron transfer activity
BN853_RS01925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BN853_RS01930	COG0277	FAD linked oxidase domain protein
BN853_RS01950	COG1649	PFAM Uncharacterised BCR, COG1649
BN853_RS01955	COG1649	PFAM Uncharacterised BCR, COG1649
BN853_RS01960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BN853_RS01965	COG3409	Peptidoglycan-binding domain 1 protein
BN853_RS01965	COG5632	N-Acetylmuramoyl-L-alanine amidase
BN853_RS01980	COG1653	transport
BN853_RS01990	COG0395	ABC-type sugar transport system, permease component
BN853_RS02010	COG1175	transmembrane transport
BN853_RS02015	COG0395	ABC-type sugar transport system, permease component
BN853_RS02025	COG3876	Protein conserved in bacteria
BN853_RS02030	COG1472	Belongs to the glycosyl hydrolase 3 family
BN853_RS02035	COG2971	BadF BadG BcrA BcrD
BN853_RS02045	COG0363	glucosamine-6-phosphate deaminase activity
BN853_RS02050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BN853_RS02065	COG0363	glucosamine-6-phosphate deaminase activity
BN853_RS02070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BN853_RS02080	COG2188	Transcriptional regulator
BN853_RS02125	COG0395	ABC-type sugar transport system, permease component
BN853_RS02145	COG1175	transmembrane transport
BN853_RS02150	COG0395	ABC-type sugar transport system, permease component
BN853_RS02195	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BN853_RS02205	COG5002	protein histidine kinase activity
BN853_RS02215	COG0577	efflux transmembrane transporter activity
BN853_RS02215	COG1136	(ABC) transporter
BN853_RS02220	COG0584	glycerophosphoryl diester phosphodiesterase
BN853_RS02235	COG0826	peptidase U32
BN853_RS02245	COG1472	Belongs to the glycosyl hydrolase 3 family
BN853_RS02255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BN853_RS02260	COG0495	leucyl-tRNA aminoacylation
BN853_RS02285	COG0798	PFAM Bile acid sodium symporter
BN853_RS02290	COG5001	Diguanylate cyclase
BN853_RS02290	COG3300	MHYT domain
BN853_RS02300	COG1609	Transcriptional regulator
BN853_RS02310	COG1175	transmembrane transport
BN853_RS02315	COG0395	ABC-type sugar transport system, permease component
BN853_RS02320	COG3459	Glycosyltransferase 36 associated
BN853_RS02345	COG1175	transmembrane transport
BN853_RS02350	COG0395	ABC-type sugar transport system, permease component
BN853_RS02365	COG1175	transmembrane transport
BN853_RS02370	COG0395	ABC-type sugar transport system, permease component
BN853_RS02390	COG0366	Alpha amylase catalytic
BN853_RS02395	COG1609	Transcriptional regulator
BN853_RS02405	COG3459	Glycosyltransferase 36 associated
BN853_RS02410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BN853_RS02425	COG2217	Heavy metal translocating P-type atpase
BN853_RS02430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BN853_RS02460	COG0745	RESPONSE REGULATOR receiver
BN853_RS02490	COG2217	Heavy metal translocating P-type atpase
BN853_RS02495	COG2217	Heavy metal translocating P-type atpase
BN853_RS02520	COG3177	Filamentation induced by cAMP protein fic
BN853_RS02545	COG2514	catechol 2,3-dioxygenase activity
BN853_RS02585	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BN853_RS02590	COG1242	4 iron, 4 sulfur cluster binding
BN853_RS02610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BN853_RS02615	COG0072	phenylalanine-tRNA ligase activity
BN853_RS02615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BN853_RS02620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BN853_RS02625	COG1162	GTPase activity
BN853_RS02630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BN853_RS02640	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BN853_RS02645	COG1461	Dihydroxyacetone kinase
BN853_RS02665	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BN853_RS02735	COG0542	response to heat
BN853_RS02775	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BN853_RS02785	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BN853_RS02795	COG3557	Belongs to the UPF0374 family
BN853_RS02800	COG4129	membrane
BN853_RS02835	COG4591	ABC-type transport system involved in lipoprotein release permease component
BN853_RS02840	COG1136	(ABC) transporter
BN853_RS02855	COG1982	Orn Lys Arg decarboxylase major
BN853_RS02860	COG0010	Belongs to the arginase family
BN853_RS02865	COG2356	endonuclease I
BN853_RS02875	COG1132	(ABC) transporter
BN853_RS02880	COG1132	(ABC) transporter
BN853_RS02885	COG0366	Alpha amylase catalytic
BN853_RS02895	COG1278	Cold shock
BN853_RS02905	COG0765	amino acid transport
BN853_RS02910	COG1126	abc transporter atp-binding protein
BN853_RS02930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BN853_RS02945	COG1269	ATP hydrolysis coupled proton transport
BN853_RS02975	COG1394	ATPase activity, coupled to movement of substances
BN853_RS02985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BN853_RS02990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BN853_RS03015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BN853_RS03020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BN853_RS03025	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BN853_RS03030	COG0194	GDP metabolic process
BN853_RS03035	COG1758	RNA polymerase activity
BN853_RS03040	COG0322	excinuclease ABC activity
BN853_RS03055	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BN853_RS03065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BN853_RS03080	COG1321	iron dependent repressor
BN853_RS03080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BN853_RS03085	COG1121	(ABC) transporter
BN853_RS03095	COG0779	Required for maturation of 30S ribosomal subunits
BN853_RS03100	COG0195	Participates in both transcription termination and antitermination
BN853_RS03105	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BN853_RS03115	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BN853_RS03120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BN853_RS03140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BN853_RS03145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BN853_RS03150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BN853_RS03160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BN853_RS03170	COG1704	LemA family
BN853_RS03175	COG0653	protein targeting
BN853_RS03180	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BN853_RS03185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BN853_RS03195	COG2137	regulation of response to DNA damage stimulus
BN853_RS03205	COG0058	SHG alpha-glucan phosphorylase activity
BN853_RS03210	COG0561	phosphatase activity
BN853_RS03220	COG1674	ftsk spoiiie
BN853_RS03245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BN853_RS03250	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BN853_RS03255	COG0552	protein localization to endoplasmic reticulum
BN853_RS03260	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BN853_RS03265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BN853_RS03280	COG0237	dephospho-CoA kinase activity
BN853_RS03295	COG1484	DNA-dependent DNA replication
BN853_RS03300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BN853_RS03305	COG4152	abc transporter atp-binding protein
BN853_RS03315	COG0489	protein tyrosine kinase activity
BN853_RS03320	COG0745	RESPONSE REGULATOR receiver
BN853_RS03325	COG5002	protein histidine kinase activity
BN853_RS03330	COG1073	alpha beta
BN853_RS03345	COG1960	acyl-CoA dehydrogenase activity
BN853_RS03350	COG2086	electron transfer activity
BN853_RS03430	COG1132	(ABC) transporter
BN853_RS03465	COG0546	phosphoglycolate phosphatase activity
BN853_RS03470	COG2801	Transposase and inactivated derivatives
BN853_RS03485	COG0366	Alpha amylase catalytic
BN853_RS03495	COG1523	belongs to the glycosyl hydrolase 13 family
BN853_RS03510	COG1175	transmembrane transport
BN853_RS03515	COG3833	ABC-type maltose transport systems, permease component
BN853_RS03520	COG0366	Alpha amylase catalytic
BN853_RS03545	COG0488	(ABC) transporter
BN853_RS03550	COG0534	Mate efflux family protein
BN853_RS03565	COG3845	ABC transporter
BN853_RS03570	COG4603	Belongs to the binding-protein-dependent transport system permease family
BN853_RS03575	COG1079	Belongs to the binding-protein-dependent transport system permease family
BN853_RS03580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BN853_RS03585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BN853_RS03590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BN853_RS03595	COG1420	regulation of RNA biosynthetic process
BN853_RS03600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BN853_RS03605	COG0443	Heat shock 70 kDa protein
BN853_RS03615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BN853_RS03620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BN853_RS03625	COG1702	phosphate starvation-inducible protein PhoH
BN853_RS03630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BN853_RS03635	COG0295	cytidine deaminase activity
BN853_RS03645	COG1381	Involved in DNA repair and RecF pathway recombination
BN853_RS03650	COG0423	glycine-tRNA ligase activity
BN853_RS03655	COG0358	DNA primase activity
BN853_RS03660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BN853_RS03670	COG2384	SAM-dependent methyltransferase
BN853_RS03690	COG4974	Belongs to the 'phage' integrase family
BN853_RS03720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BN853_RS03790	COG0071	Belongs to the small heat shock protein (HSP20) family
BN853_RS03800	COG2824	Alkylphosphonate utilization operon protein PhnA
BN853_RS03830	COG0356	it plays a direct role in the translocation of protons across the membrane
BN853_RS03850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BN853_RS03855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BN853_RS03860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BN853_RS03865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BN853_RS03870	COG0778	Nitroreductase
BN853_RS03880	COG1194	a g-specific adenine glycosylase
BN853_RS03900	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BN853_RS03905	COG0012	GTP binding
BN853_RS03910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BN853_RS03915	COG1799	cell septum assembly
BN853_RS03930	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BN853_RS03945	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BN853_RS03950	COG0813	purine-nucleoside phosphorylase activity
BN853_RS03955	COG0612	Peptidase, M16
BN853_RS03960	COG0612	Peptidase, M16
BN853_RS03965	COG0629	single-stranded DNA binding
BN853_RS03970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BN853_RS03975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BN853_RS03980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BN853_RS03990	COG0406	alpha-ribazole phosphatase activity
BN853_RS03995	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BN853_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
BN853_RS04005	COG3859	Proton-coupled thiamine transporter YuaJ
BN853_RS04010	COG3331	DNA recombination
BN853_RS04070	COG0395	ABC-type sugar transport system, permease component
BN853_RS04090	COG0395	ABC-type sugar transport system, permease component
BN853_RS04100	COG2801	Transposase and inactivated derivatives
BN853_RS04110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BN853_RS04120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BN853_RS04125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BN853_RS04130	COG1490	D-aminoacyl-tRNA deacylase activity
BN853_RS04145	COG0124	histidyl-tRNA synthetase
BN853_RS04155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BN853_RS04165	COG3480	Lon protease (S16) C-terminal proteolytic domain
BN853_RS04175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BN853_RS04180	COG0564	pseudouridine synthase activity
BN853_RS04220	COG0632	four-way junction helicase activity
BN853_RS04225	COG2255	four-way junction helicase activity
BN853_RS04235	COG1968	undecaprenyl-diphosphatase activity
BN853_RS04255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BN853_RS04260	COG1363	Peptidase, m42
BN853_RS04265	COG0656	L-ascorbic acid biosynthetic process
BN853_RS04270	COG0246	Mannitol dehydrogenase
BN853_RS04275	COG2721	sulfolactate sulfo-lyase activity
BN853_RS04280	COG1904	glucuronate isomerase
BN853_RS04285	COG4677	pectinesterase activity
BN853_RS04295	COG4209	transmembrane transport
BN853_RS04300	COG0395	ABC-type sugar transport system, permease component
BN853_RS04320	COG3842	ATPase activity
BN853_RS04340	COG0800	Aldolase
BN853_RS04375	COG1028	Short-chain dehydrogenase reductase Sdr
BN853_RS04380	COG4684	Psort location CytoplasmicMembrane, score
BN853_RS04385	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BN853_RS04390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BN853_RS04395	COG0006	proline dipeptidase activity
BN853_RS04410	COG1131	(ABC) transporter
BN853_RS04425	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BN853_RS04430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BN853_RS04440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BN853_RS04470	COG3763	UPF0154 protein
BN853_RS04485	COG0187	DNA topoisomerase II activity
BN853_RS04490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BN853_RS04495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BN853_RS04515	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BN853_RS04520	COG4974	Belongs to the 'phage' integrase family
BN853_RS04530	COG0667	Aldo Keto reductase
BN853_RS04550	COG1185	polyribonucleotide nucleotidyltransferase activity
BN853_RS04555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BN853_RS04560	COG3870	Protein conserved in bacteria
BN853_RS04565	COG0196	riboflavin kinase activity
BN853_RS04570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BN853_RS04580	COG3118	belongs to the thioredoxin family
BN853_RS04585	COG1193	negative regulation of DNA recombination
BN853_RS04595	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BN853_RS04600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BN853_RS04605	COG0596	Alpha beta hydrolase
BN853_RS04640	COG0285	dihydrofolate synthase activity
BN853_RS04655	COG1307	EDD domain protein, DegV family
BN853_RS04660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BN853_RS04665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BN853_RS04670	COG0544	peptidyl-prolyl cis-trans isomerase activity
BN853_RS04680	COG2217	Heavy metal translocating P-type atpase
BN853_RS04690	COG1902	pentaerythritol trinitrate reductase activity
BN853_RS04695	COG2357	RelA SpoT domain protein
BN853_RS04700	COG2267	carboxylic ester hydrolase activity
BN853_RS04705	COG2267	carboxylic ester hydrolase activity
BN853_RS04710	COG0427	acetyl-CoA hydrolase
BN853_RS04745	COG1028	Short-chain dehydrogenase reductase Sdr
BN853_RS04750	COG0183	Belongs to the thiolase family
BN853_RS04830	COG5001	Diguanylate cyclase
BN853_RS04830	COG1716	ATPase activity
BN853_RS04835	COG1716	ATPase activity
BN853_RS04835	COG5001	Diguanylate cyclase
BN853_RS04840	COG1472	Belongs to the glycosyl hydrolase 3 family
BN853_RS04845	COG3706	GGDEF domain
BN853_RS04850	COG1584	GPR1 FUN34 yaaH family protein
BN853_RS04860	COG1126	abc transporter atp-binding protein
BN853_RS04865	COG0765	amino acid transport
BN853_RS04870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BN853_RS04875	COG2235	arginine
BN853_RS04880	COG2084	Dehydrogenase
BN853_RS04885	COG5001	Diguanylate cyclase
BN853_RS04890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BN853_RS04895	COG1464	Belongs to the NlpA lipoprotein family
BN853_RS04900	COG2011	ABC-type metal ion transport system permease component
BN853_RS04920	COG3634	alkyl hydroperoxide reductase activity
BN853_RS04940	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BN853_RS04955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BN853_RS04960	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BN853_RS04965	COG1272	protein, Hemolysin III
BN853_RS04975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BN853_RS04985	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BN853_RS04990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BN853_RS05005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BN853_RS05050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BN853_RS05055	COG0569	domain protein
BN853_RS05075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BN853_RS05080	COG1160	GTP binding
BN853_RS05090	COG1187	pseudouridine synthase activity
BN853_RS05095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BN853_RS05100	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BN853_RS05105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BN853_RS05110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BN853_RS05120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BN853_RS05135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BN853_RS05140	COG1692	metallophosphoesterase
BN853_RS05145	COG1418	mRNA catabolic process
BN853_RS05145	COG4372	Transposase
BN853_RS05155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BN853_RS05165	COG0268	Binds directly to 16S ribosomal RNA
BN853_RS05175	COG1466	dna polymerase III delta subunit
BN853_RS05195	COG0799	negative regulation of ribosome biogenesis
BN853_RS05210	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BN853_RS05215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BN853_RS05225	COG0826	peptidase U32
BN853_RS05230	COG0826	peptidase U32
BN853_RS05235	COG4122	O-methyltransferase activity
BN853_RS05240	COG3906	Belongs to the UPF0473 family
BN853_RS05245	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BN853_RS05250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BN853_RS05260	COG1752	Esterase of the alpha-beta hydrolase superfamily
BN853_RS05270	COG0557	exoribonuclease II activity
BN853_RS05275	COG0148	phosphopyruvate hydratase activity
BN853_RS05280	COG0671	phosphoesterase, PA-phosphatase related
BN853_RS05300	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BN853_RS05305	COG1136	(ABC) transporter
BN853_RS05330	COG1454	alcohol dehydrogenase
BN853_RS05330	COG1012	belongs to the aldehyde dehydrogenase family
BN853_RS05340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BN853_RS05360	COG1846	Transcriptional regulator
BN853_RS05365	COG0386	Belongs to the glutathione peroxidase family
BN853_RS05375	COG2801	Transposase and inactivated derivatives
BN853_RS05420	COG0446	pyridine nucleotide-disulphide oxidoreductase
BN853_RS05425	COG0194	GDP metabolic process
BN853_RS05455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BN853_RS05455	COG1522	sequence-specific DNA binding
BN853_RS05470	COG3177	Filamentation induced by cAMP protein fic
BN853_RS05480	COG0640	Transcriptional regulator
BN853_RS05485	COG2217	Heavy metal translocating P-type atpase
BN853_RS05505	COG1253	flavin adenine dinucleotide binding
BN853_RS05525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BN853_RS05555	COG3093	addiction module antidote protein HigA
BN853_RS05595	COG1122	ATPase activity
BN853_RS05630	COG0297	glycogen (starch) synthase activity
BN853_RS05645	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BN853_RS05650	COG0513	Belongs to the DEAD box helicase family
BN853_RS05655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BN853_RS05660	COG1136	(ABC) transporter
BN853_RS05665	COG1136	(ABC) transporter
BN853_RS05665	COG0577	efflux transmembrane transporter activity
BN853_RS05675	COG0497	DNA recombination
BN853_RS05685	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BN853_RS05690	COG1722	exodeoxyribonuclease VII activity
BN853_RS05695	COG1570	exodeoxyribonuclease VII activity
BN853_RS05700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BN853_RS05705	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BN853_RS05710	COG1177	transmembrane transport
BN853_RS05715	COG1176	ABC-type spermidine putrescine transport system, permease component I
BN853_RS05720	COG3839	Belongs to the ABC transporter superfamily
BN853_RS05735	COG0584	glycerophosphoryl diester phosphodiesterase
BN853_RS05745	COG0275	rRNA processing
BN853_RS05770	COG2304	oxidoreductase activity
BN853_RS05775	COG0745	RESPONSE REGULATOR receiver
BN853_RS05780	COG5002	protein histidine kinase activity
BN853_RS05780	COG3850	Histidine kinase
BN853_RS05800	COG2356	endonuclease I
BN853_RS05805	COG0488	(ABC) transporter
BN853_RS05825	COG0765	amino acid transport
BN853_RS05830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BN853_RS05850	COG1253	flavin adenine dinucleotide binding
BN853_RS05860	COG0564	pseudouridine synthase activity
BN853_RS05875	COG1187	pseudouridine synthase activity
BN853_RS05880	COG0009	L-threonylcarbamoyladenylate synthase
BN853_RS05885	COG2199	diguanylate cyclase activity
BN853_RS05890	COG1132	(ABC) transporter
BN853_RS05895	COG1132	(ABC) transporter
BN853_RS05900	COG0667	Aldo Keto reductase
BN853_RS05910	COG2081	HI0933 family
BN853_RS05930	COG1695	Transcriptional regulator
BN853_RS05940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BN853_RS05940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BN853_RS05945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BN853_RS05945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BN853_RS05950	COG0704	Plays a role in the regulation of phosphate uptake
BN853_RS05955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BN853_RS05960	COG0581	inorganic phosphate transmembrane transporter activity
BN853_RS05965	COG0573	inorganic phosphate transmembrane transporter activity
BN853_RS05975	COG0745	RESPONSE REGULATOR receiver
BN853_RS06020	COG1131	(ABC) transporter
BN853_RS06030	COG1131	(ABC) transporter
BN853_RS06040	COG0537	adenosine 5'-monophosphoramidase activity
BN853_RS06050	COG3426	butyrate kinase activity
BN853_RS06055	COG0280	phosphate acetyltransferase
BN853_RS06060	COG1199	ATP-dependent helicase activity
BN853_RS06065	COG0494	nUDIX hydrolase
BN853_RS06080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BN853_RS06085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BN853_RS06085	COG1321	iron dependent repressor
BN853_RS06090	COG1121	(ABC) transporter
BN853_RS06095	COG0803	Belongs to the bacterial solute-binding protein 9 family
BN853_RS06100	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BN853_RS06120	COG3706	GGDEF domain
BN853_RS06145	COG0668	transmembrane transport
BN853_RS06150	COG0513	Belongs to the DEAD box helicase family
BN853_RS06160	COG1187	pseudouridine synthase activity
BN853_RS06165	COG1012	belongs to the aldehyde dehydrogenase family
BN853_RS06180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BN853_RS06185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BN853_RS06195	COG0482	sulfurtransferase activity
BN853_RS06205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BN853_RS06220	COG0275	rRNA processing
BN853_RS06230	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BN853_RS06250	COG4607	ABC-type enterochelin transport system periplasmic component
BN853_RS06255	COG4604	ABC transporter, ATP-binding protein
BN853_RS06260	COG4605	iron ion homeostasis
BN853_RS06265	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BN853_RS06290	COG1045	serine acetyltransferase
BN853_RS06300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BN853_RS06310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BN853_RS06315	COG1760	l-serine dehydratase
BN853_RS06320	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BN853_RS06325	COG2239	Acts as a magnesium transporter
BN853_RS06330	COG2239	Acts as a magnesium transporter
BN853_RS06335	COG1132	(ABC) transporter
BN853_RS06340	COG1132	(ABC) transporter
BN853_RS06360	COG2195	Cleaves the N-terminal amino acid of tripeptides
BN853_RS06375	COG0584	glycerophosphoryl diester phosphodiesterase
BN853_RS06390	COG0686	Belongs to the AlaDH PNT family
BN853_RS06405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BN853_RS06430	COG0489	protein tyrosine kinase activity
BN853_RS06440	COG1164	Oligoendopeptidase f
BN853_RS06445	COG0556	nucleotide-excision repair
BN853_RS06460	COG1283	sodium-dependent phosphate transmembrane transporter activity
BN853_RS06465	COG2223	nitrite transmembrane transporter activity
BN853_RS06475	COG0205	6-phosphofructokinase activity
BN853_RS06480	COG0205	6-phosphofructokinase activity
BN853_RS06495	COG0587	DNA-directed DNA polymerase activity
BN853_RS06505	COG1132	(ABC) transporter
BN853_RS06510	COG1132	(ABC) transporter
BN853_RS06530	COG2801	Transposase and inactivated derivatives
BN853_RS06540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BN853_RS06550	COG1733	regulation of RNA biosynthetic process
BN853_RS06615	COG0737	Belongs to the 5'-nucleotidase family
BN853_RS06630	COG2059	Chromate
BN853_RS06695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BN853_RS06705	COG0534	Mate efflux family protein
BN853_RS06765	COG2096	Adenosyltransferase
BN853_RS06770	COG0750	zinc metalloprotease
BN853_RS06780	COG4589	Belongs to the CDS family
BN853_RS06785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BN853_RS06795	COG0233	cytoplasmic translational termination
BN853_RS06800	COG0528	UMP kinase activity
BN853_RS06805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BN853_RS06810	COG0052	Belongs to the universal ribosomal protein uS2 family
BN853_RS06830	COG0756	dUTP diphosphatase activity
BN853_RS06835	COG0494	nUDIX hydrolase
BN853_RS06840	COG4974	Belongs to the 'phage' integrase family
BN853_RS06845	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BN853_RS06850	COG1609	Transcriptional regulator
BN853_RS06860	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BN853_RS06865	COG1177	transmembrane transport
BN853_RS06870	COG1176	ABC-type spermidine putrescine transport system, permease component I
BN853_RS06875	COG3842	ATPase activity
BN853_RS06890	COG0456	acetyltransferase
BN853_RS06910	COG1393	Belongs to the ArsC family
BN853_RS06920	COG0180	Tryptophanyl-tRNA synthetase
BN853_RS06930	COG1597	lipid kinase activity
BN853_RS06935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BN853_RS06940	COG1609	Transcriptional regulator
BN853_RS06945	COG0335	large ribosomal subunit rRNA binding
BN853_RS06950	COG0336	Belongs to the RNA methyltransferase TrmD family
BN853_RS06955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BN853_RS06960	COG1837	Belongs to the UPF0109 family
BN853_RS06965	COG0228	four-way junction DNA binding
BN853_RS06980	COG0242	peptide deformylase activity
BN853_RS06995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BN853_RS07000	COG0301	tRNA thio-modification
BN853_RS07005	COG1956	GAF domain-containing protein
BN853_RS07010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BN853_RS07015	COG3706	GGDEF domain
BN853_RS07040	COG0170	dolichyl monophosphate biosynthetic process
BN853_RS07050	COG1233	COG1233 Phytoene dehydrogenase and related
BN853_RS07060	COG0149	triose-phosphate isomerase activity
BN853_RS07075	COG0126	phosphoglycerate kinase activity
BN853_RS07085	COG3842	ATPase activity
BN853_RS07095	COG3835	regulator
BN853_RS07105	COG0719	Fe-S assembly protein
BN853_RS07110	COG0822	iron-sulfur transferase activity
BN853_RS07115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BN853_RS07120	COG0719	Fe-S assembly protein
BN853_RS07125	COG0396	ATPase activity
BN853_RS07140	COG0444	Belongs to the ABC transporter superfamily
BN853_RS07145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BN853_RS07150	COG0601	transmembrane transport
BN853_RS07165	COG4886	Leucine-rich repeat (LRR) protein
BN853_RS07185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BN853_RS07195	COG2217	Heavy metal translocating P-type atpase
BN853_RS07260	COG1803	Methylglyoxal synthase
BN853_RS07265	COG4974	Belongs to the 'phage' integrase family
BN853_RS07305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BN853_RS07320	COG2081	HI0933 family
BN853_RS07340	COG0628	permease
BN853_RS07350	COG0783	Belongs to the Dps family
BN853_RS07355	COG1307	EDD domain protein, DegV family
BN853_RS07360	COG0531	amino acid
BN853_RS07370	COG2832	Protein of unknown function (DUF454)
BN853_RS07385	COG1506	peptidase
BN853_RS07385	COG0823	Involved in the tonB-independent uptake of proteins
BN853_RS07385	COG4946	Tricorn protease homolog
BN853_RS07415	COG1054	Belongs to the UPF0176 family
BN853_RS07425	COG3833	ABC-type maltose transport systems, permease component
BN853_RS07445	COG1733	regulation of RNA biosynthetic process
BN853_RS07485	COG0346	lactoylglutathione lyase activity
BN853_RS07490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BN853_RS07495	COG0400	carboxylic ester hydrolase activity
BN853_RS07505	COG1595	DNA-templated transcription, initiation
BN853_RS07565	COG1597	lipid kinase activity
BN853_RS07570	COG0517	IMP dehydrogenase activity
BN853_RS07570	COG4175	Glycine betaine
BN853_RS07585	COG0668	transmembrane transport
BN853_RS07605	COG3706	GGDEF domain
BN853_RS07610	COG0326	Molecular chaperone. Has ATPase activity
BN853_RS07615	COG2801	Transposase and inactivated derivatives
BN853_RS07625	COG2199	diguanylate cyclase activity
BN853_RS07640	COG2356	endonuclease I
BN853_RS07665	COG1132	(ABC) transporter
BN853_RS07670	COG0513	Belongs to the DEAD box helicase family
BN853_RS07725	COG5001	Diguanylate cyclase
BN853_RS07740	COG0444	Belongs to the ABC transporter superfamily
BN853_RS07745	COG4608	Belongs to the ABC transporter superfamily
BN853_RS07750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BN853_RS07795	COG0640	Transcriptional regulator
BN853_RS07800	COG2217	Heavy metal translocating P-type atpase
BN853_RS07810	COG2801	Transposase and inactivated derivatives
BN853_RS07830	COG1136	(ABC) transporter
BN853_RS07865	COG2217	Heavy metal translocating P-type atpase
BN853_RS07890	COG3655	Transcriptional regulator
BN853_RS07945	COG2801	Transposase and inactivated derivatives
BN853_RS07985	COG1028	Short-chain dehydrogenase reductase Sdr
BN853_RS07990	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BN853_RS07995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BN853_RS08005	COG0561	phosphatase activity
BN853_RS08035	COG3590	peptidase
BN853_RS08080	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BN853_RS08115	COG2502	aspartate--ammonia ligase
BN853_RS08140	COG2183	response to ionizing radiation
BN853_RS08150	COG0736	holo-[acyl-carrier-protein] synthase activity
BN853_RS08155	COG1481	regulation of sporulation
BN853_RS08160	COG0492	ferredoxin-NADP+ reductase activity
BN853_RS08165	COG0546	phosphoglycolate phosphatase activity
BN853_RS08170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BN853_RS08175	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BN853_RS08185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BN853_RS08190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BN853_RS08200	COG0210	DNA helicase
BN853_RS08205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BN853_RS08210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BN853_RS08220	COG1214	PFAM Peptidase M22, glycoprotease
BN853_RS08225	COG0802	atpase or kinase
BN853_RS08230	COG2801	Transposase and inactivated derivatives
BN853_RS08235	COG2274	protein secretion by the type I secretion system
BN853_RS08240	COG0166	Belongs to the GPI family
BN853_RS08250	COG4447	cellulose binding
BN853_RS08255	COG1595	DNA-templated transcription, initiation
BN853_RS08260	COG1098	S1 RNA binding domain
BN853_RS08275	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BN853_RS08280	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BN853_RS08290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BN853_RS08290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BN853_RS08320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BN853_RS08330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BN853_RS08335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BN853_RS08345	COG2801	Transposase and inactivated derivatives
BN853_RS08355	COG0602	queuosine metabolic process
BN853_RS08360	COG1328	CTP reductase activity
BN853_RS08370	COG0037	tRNA processing
BN853_RS08375	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BN853_RS08380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BN853_RS08385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BN853_RS08420	COG0504	CTP synthase activity
BN853_RS08445	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BN853_RS08450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BN853_RS08455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BN853_RS08465	COG1285	pathogenesis
BN853_RS08470	COG0037	tRNA processing
BN853_RS08475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BN853_RS08480	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BN853_RS08485	COG0574	Belongs to the PEP-utilizing enzyme family
BN853_RS08485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BN853_RS08515	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BN853_RS08525	COG3706	GGDEF domain
BN853_RS08530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BN853_RS08570	COG0577	efflux transmembrane transporter activity
BN853_RS08570	COG1136	(ABC) transporter
BN853_RS08600	COG0459	protein refolding
BN853_RS08605	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BN853_RS08630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BN853_RS08635	COG0732	type I restriction modification DNA specificity domain
BN853_RS08640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BN853_RS08660	COG0395	ABC-type sugar transport system, permease component
BN853_RS08670	COG3842	ATPase activity
BN853_RS08680	COG0017	Asparaginyl-tRNA synthetase
BN853_RS08710	COG0594	ribonuclease P activity
BN853_RS08715	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BN853_RS08730	COG0085	RNA polymerase activity
BN853_RS08755	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BN853_RS08770	COG4608	Belongs to the ABC transporter superfamily