locus-tag	class	description
NYR34_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NYR34_RS00010	COG0592	DNA-directed DNA polymerase activity
NYR34_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NYR34_RS00025	COG0187	DNA topoisomerase II activity
NYR34_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NYR34_RS00040	COG1725	Transcriptional regulator
NYR34_RS00045	COG1131	(ABC) transporter
NYR34_RS00055	COG0577	efflux transmembrane transporter activity
NYR34_RS00055	COG1136	(ABC) transporter
NYR34_RS00060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NYR34_RS00065	COG0745	RESPONSE REGULATOR receiver
NYR34_RS00070	COG2770	Histidine kinase
NYR34_RS00070	COG2205	protein histidine kinase activity
NYR34_RS00075	COG0537	adenosine 5'-monophosphoramidase activity
NYR34_RS00080	COG4869	propanediol catabolic process
NYR34_RS00085	COG1078	dGTPase activity
NYR34_RS00090	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NYR34_RS00095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NYR34_RS00100	COG2088	sporulation resulting in formation of a cellular spore
NYR34_RS00105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NYR34_RS00110	COG0193	aminoacyl-tRNA hydrolase activity
NYR34_RS00115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NYR34_RS00130	COG0110	maltose O-acetyltransferase activity
NYR34_RS00140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NYR34_RS00165	COG1882	Formate acetyltransferase
NYR34_RS00170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NYR34_RS00175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NYR34_RS00180	COG3022	response to hydroperoxide
NYR34_RS00195	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NYR34_RS00200	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NYR34_RS00205	COG0584	glycerophosphoryl diester phosphodiesterase
NYR34_RS00235	COG0217	transcriptional regulatory protein
NYR34_RS00250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NYR34_RS00260	COG4658	electron transport chain
NYR34_RS00320	COG0590	tRNA wobble adenosine to inosine editing
NYR34_RS00340	COG0445	tRNA wobble uridine modification
NYR34_RS00345	COG0357	Ribosomal RNA small subunit methyltransferase G
NYR34_RS00445	COG2084	Dehydrogenase
NYR34_RS00450	COG1307	EDD domain protein, DegV family
NYR34_RS00465	COG0051	transcription antitermination factor activity, RNA binding
NYR34_RS00470	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NYR34_RS00475	COG0088	Forms part of the polypeptide exit tunnel
NYR34_RS00480	COG0089	rRNA binding
NYR34_RS00485	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NYR34_RS00490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NYR34_RS00495	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NYR34_RS00500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NYR34_RS00505	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NYR34_RS00510	COG0255	Belongs to the universal ribosomal protein uL29 family
NYR34_RS00515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NYR34_RS00520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NYR34_RS00530	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NYR34_RS00535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NYR34_RS00540	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NYR34_RS00545	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NYR34_RS00550	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NYR34_RS00555	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NYR34_RS00560	COG1841	ribosomal large subunit assembly
NYR34_RS00565	COG0200	Binds to the 23S rRNA
NYR34_RS00570	COG0201	protein transport
NYR34_RS00575	COG0563	adenylate kinase activity
NYR34_RS00580	COG0024	Methionine aminopeptidase
NYR34_RS00585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NYR34_RS00590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NYR34_RS00595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NYR34_RS00600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NYR34_RS00605	COG0202	RNA polymerase activity
NYR34_RS00610	COG0203	ribosomal protein L17
NYR34_RS00625	COG0519	Catalyzes the synthesis of GMP from XMP
NYR34_RS00640	COG0492	ferredoxin-NADP+ reductase activity
NYR34_RS00645	COG3118	belongs to the thioredoxin family
NYR34_RS00650	COG1122	ATPase activity
NYR34_RS00655	COG1122	ATPase activity
NYR34_RS00660	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NYR34_RS00665	COG0101	tRNA pseudouridine synthase activity
NYR34_RS00670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NYR34_RS00675	COG0470	DNA polymerase III
NYR34_RS00680	COG2890	protein-(glutamine-N5) methyltransferase activity
NYR34_RS00685	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NYR34_RS00700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NYR34_RS00705	COG0393	Putative heavy-metal-binding
NYR34_RS00715	COG3706	GGDEF domain
NYR34_RS00720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NYR34_RS00725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NYR34_RS00730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NYR34_RS00740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NYR34_RS00750	COG0215	cysteine-tRNA ligase activity
NYR34_RS00755	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NYR34_RS00760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NYR34_RS00780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NYR34_RS00790	COG0250	Participates in transcription elongation, termination and antitermination
NYR34_RS00800	COG2801	Transposase and inactivated derivatives
NYR34_RS00810	COG2356	endonuclease I
NYR34_RS00855	COG2356	endonuclease I
NYR34_RS00875	COG2514	catechol 2,3-dioxygenase activity
NYR34_RS00885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NYR34_RS00890	COG0081	regulation of translation
NYR34_RS00895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NYR34_RS00900	COG0222	ribosome binding
NYR34_RS00905	COG2813	Specifically methylates the guanine in position
NYR34_RS00910	COG0085	RNA polymerase activity
NYR34_RS00915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NYR34_RS00930	COG5001	Diguanylate cyclase
NYR34_RS00930	COG3300	MHYT domain
NYR34_RS00945	COG1454	alcohol dehydrogenase
NYR34_RS00945	COG1012	belongs to the aldehyde dehydrogenase family
NYR34_RS00965	COG1649	PFAM Uncharacterised BCR, COG1649
NYR34_RS00985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NYR34_RS00990	COG0049	tRNA binding
NYR34_RS00995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NYR34_RS01000	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NYR34_RS01005	COG0084	hydrolase, TatD family'
NYR34_RS01015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NYR34_RS01020	COG1058	Belongs to the CinA family
NYR34_RS01020	COG1546	Belongs to the CinA family
NYR34_RS01025	COG0360	Binds together with S18 to 16S ribosomal RNA
NYR34_RS01030	COG0629	single-stranded DNA binding
NYR34_RS01035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NYR34_RS01040	COG0359	binds to the 23S rRNA
NYR34_RS01040	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NYR34_RS01045	COG0305	Participates in initiation and elongation during chromosome replication
NYR34_RS01050	COG0783	Belongs to the Dps family
NYR34_RS01065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NYR34_RS01075	COG0009	L-threonylcarbamoyladenylate synthase
NYR34_RS01080	COG1217	gtp-binding protein TYPA
NYR34_RS01085	COG0698	ribose 5-phosphate isomerase
NYR34_RS01090	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NYR34_RS01100	COG1739	Uncharacterized protein family UPF0029
NYR34_RS01105	COG0617	tRNA 3'-terminal CCA addition
NYR34_RS01110	COG3481	metal-dependent phosphohydrolase, HD sub domain
NYR34_RS01125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NYR34_RS01135	COG1970	mechanosensitive ion channel activity
NYR34_RS01140	COG1307	EDD domain protein, DegV family
NYR34_RS01145	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NYR34_RS01150	COG0287	Prephenate dehydrogenase
NYR34_RS01155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NYR34_RS01160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NYR34_RS01165	COG1605	Chorismate mutase
NYR34_RS01165	COG0077	Prephenate dehydratase
NYR34_RS01170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NYR34_RS01175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NYR34_RS01180	COG4129	membrane
NYR34_RS01190	COG3425	synthase
NYR34_RS01200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NYR34_RS01205	COG0416	fatty acid biosynthetic process
NYR34_RS01210	COG0571	ribonuclease III activity
NYR34_RS01220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NYR34_RS01230	COG1132	(ABC) transporter
NYR34_RS01235	COG1132	(ABC) transporter
NYR34_RS01270	COG2706	6-phosphogluconolactonase activity
NYR34_RS01275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NYR34_RS01280	COG0495	leucyl-tRNA aminoacylation
NYR34_RS01290	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NYR34_RS01295	COG1242	4 iron, 4 sulfur cluster binding
NYR34_RS01305	COG2176	DNA-directed DNA polymerase activity
NYR34_RS01315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NYR34_RS01320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NYR34_RS01320	COG0072	phenylalanine-tRNA ligase activity
NYR34_RS01325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NYR34_RS01330	COG1162	GTPase activity
NYR34_RS01335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NYR34_RS01345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NYR34_RS01350	COG1461	Dihydroxyacetone kinase
NYR34_RS01375	COG1472	Belongs to the glycosyl hydrolase 3 family
NYR34_RS01380	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NYR34_RS01390	COG0363	glucosamine-6-phosphate deaminase activity
NYR34_RS01410	COG1609	Transcriptional regulator
NYR34_RS01415	COG2188	Transcriptional regulator
NYR34_RS01450	COG1175	transmembrane transport
NYR34_RS01455	COG0395	ABC-type sugar transport system, permease component
NYR34_RS01480	COG0395	ABC-type sugar transport system, permease component
NYR34_RS01525	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NYR34_RS01530	COG0363	glucosamine-6-phosphate deaminase activity
NYR34_RS01545	COG3557	Belongs to the UPF0374 family
NYR34_RS01550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NYR34_RS01555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NYR34_RS01575	COG2226	methyltransferase
NYR34_RS01585	COG1278	Cold shock
NYR34_RS01595	COG2996	Protein conserved in bacteria
NYR34_RS01600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NYR34_RS01610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NYR34_RS01620	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NYR34_RS01630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NYR34_RS01640	COG0194	GDP metabolic process
NYR34_RS01650	COG0322	excinuclease ABC activity
NYR34_RS01675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NYR34_RS01685	COG2017	converts alpha-aldose to the beta-anomer
NYR34_RS01710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NYR34_RS01715	COG0779	Required for maturation of 30S ribosomal subunits
NYR34_RS01720	COG0195	Participates in both transcription termination and antitermination
NYR34_RS01725	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NYR34_RS01730	COG1358	cellular component organization or biogenesis
NYR34_RS01735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NYR34_RS01740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NYR34_RS01750	COG3279	Response regulator of the LytR AlgR family
NYR34_RS01755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NYR34_RS01760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NYR34_RS01765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NYR34_RS01775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NYR34_RS01785	COG0653	protein targeting
NYR34_RS01790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NYR34_RS01795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NYR34_RS01805	COG0561	phosphatase activity
NYR34_RS01815	COG1674	ftsk spoiiie
NYR34_RS01820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NYR34_RS01825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NYR34_RS01830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NYR34_RS01840	COG1131	(ABC) transporter
NYR34_RS01850	COG1136	(ABC) transporter
NYR34_RS01860	COG0826	peptidase U32
NYR34_RS01865	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NYR34_RS01870	COG0552	protein localization to endoplasmic reticulum
NYR34_RS01875	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NYR34_RS01880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NYR34_RS01900	COG1484	DNA-dependent DNA replication
NYR34_RS01905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NYR34_RS01910	COG4152	abc transporter atp-binding protein
NYR34_RS01920	COG0489	protein tyrosine kinase activity
NYR34_RS01935	COG2003	Belongs to the UPF0758 family
NYR34_RS01945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NYR34_RS01960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NYR34_RS02015	COG0632	four-way junction helicase activity
NYR34_RS02020	COG2255	four-way junction helicase activity
NYR34_RS02025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NYR34_RS02030	COG1968	undecaprenyl-diphosphatase activity
NYR34_RS02050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NYR34_RS02055	COG1363	Peptidase, m42
NYR34_RS02060	COG0656	L-ascorbic acid biosynthetic process
NYR34_RS02065	COG0187	DNA topoisomerase II activity
NYR34_RS02070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NYR34_RS02085	COG1307	EDD domain protein, DegV family
NYR34_RS02105	COG1744	ABC transporter substrate-binding protein PnrA-like
NYR34_RS02110	COG3845	ABC transporter
NYR34_RS02115	COG4603	Belongs to the binding-protein-dependent transport system permease family
NYR34_RS02120	COG1079	Belongs to the binding-protein-dependent transport system permease family
NYR34_RS02125	COG1428	Deoxynucleoside kinase
NYR34_RS02130	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NYR34_RS02135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NYR34_RS02140	COG0509	glycine decarboxylation via glycine cleavage system
NYR34_RS02145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NYR34_RS02155	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NYR34_RS02165	COG0148	phosphopyruvate hydratase activity
NYR34_RS02170	COG1803	Methylglyoxal synthase
NYR34_RS02180	COG0557	exoribonuclease II activity
NYR34_RS02185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NYR34_RS02190	COG1752	Esterase of the alpha-beta hydrolase superfamily
NYR34_RS02195	COG0671	phosphoesterase, PA-phosphatase related
NYR34_RS02235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NYR34_RS02240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NYR34_RS02255	COG1132	(ABC) transporter
NYR34_RS02260	COG1132	(ABC) transporter
NYR34_RS02270	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NYR34_RS02275	COG3547	Transposase (IS116 IS110 IS902 family)
NYR34_RS02280	COG0071	Belongs to the small heat shock protein (HSP20) family
NYR34_RS02285	COG0277	FAD linked oxidase domain protein
NYR34_RS02360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NYR34_RS02365	COG2824	Alkylphosphonate utilization operon protein PhnA
NYR34_RS02395	COG2608	mercury ion transmembrane transporter activity
NYR34_RS02400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NYR34_RS02400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NYR34_RS02400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NYR34_RS02430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NYR34_RS02455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NYR34_RS02455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NYR34_RS02540	COG1070	Carbohydrate kinase
NYR34_RS02565	COG1215	transferase activity, transferring glycosyl groups
NYR34_RS02590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NYR34_RS02620	COG3706	GGDEF domain
NYR34_RS02645	COG5001	Diguanylate cyclase
NYR34_RS02650	COG2217	Heavy metal translocating P-type atpase
NYR34_RS02675	COG0439	Biotin carboxylase
NYR34_RS02680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NYR34_RS02690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NYR34_RS02695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NYR34_RS02700	COG1028	Short-chain dehydrogenase reductase Sdr
NYR34_RS02705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NYR34_RS02710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NYR34_RS02735	COG0668	transmembrane transport
NYR34_RS02745	COG0492	ferredoxin-NADP+ reductase activity
NYR34_RS02780	COG3839	Belongs to the ABC transporter superfamily
NYR34_RS02785	COG1176	ABC-type spermidine putrescine transport system, permease component I
NYR34_RS02790	COG1177	transmembrane transport
NYR34_RS02805	COG1570	exodeoxyribonuclease VII activity
NYR34_RS02810	COG1722	exodeoxyribonuclease VII activity
NYR34_RS02820	COG0497	DNA recombination
NYR34_RS02835	COG0513	Belongs to the DEAD box helicase family
NYR34_RS02840	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NYR34_RS02860	COG1937	Protein conserved in bacteria
NYR34_RS02865	COG0018	arginyl-trna synthetase
NYR34_RS02890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NYR34_RS02900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NYR34_RS02915	COG1272	protein, Hemolysin III
NYR34_RS02920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NYR34_RS02950	COG1309	transcriptional regulator
NYR34_RS02955	COG0183	Belongs to the thiolase family
NYR34_RS02960	COG1028	Short-chain dehydrogenase reductase Sdr
NYR34_RS02970	COG0427	acetyl-CoA hydrolase
NYR34_RS02985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NYR34_RS03020	COG0640	Transcriptional regulator
NYR34_RS03025	COG2217	Heavy metal translocating P-type atpase
NYR34_RS03040	COG0513	Belongs to the DEAD box helicase family
NYR34_RS03045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NYR34_RS03070	COG0297	glycogen (starch) synthase activity
NYR34_RS03075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NYR34_RS03085	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
NYR34_RS03100	COG2135	peptidase activity
NYR34_RS03115	COG0058	SHG alpha-glucan phosphorylase activity
NYR34_RS03125	COG1609	Transcriptional regulator
NYR34_RS03130	COG1523	belongs to the glycosyl hydrolase 13 family
NYR34_RS03145	COG0656	L-ascorbic acid biosynthetic process
NYR34_RS03150	COG0544	peptidyl-prolyl cis-trans isomerase activity
NYR34_RS03155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NYR34_RS03160	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NYR34_RS03165	COG1307	EDD domain protein, DegV family
NYR34_RS03185	COG0285	dihydrofolate synthase activity
NYR34_RS03190	COG2267	carboxylic ester hydrolase activity
NYR34_RS03195	COG2814	Major facilitator Superfamily
NYR34_RS03215	COG1420	regulation of RNA biosynthetic process
NYR34_RS03220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NYR34_RS03225	COG0443	Heat shock 70 kDa protein
NYR34_RS03235	COG0095	Lipoate-protein ligase
NYR34_RS03240	COG1399	metal-binding, possibly nucleic acid-binding protein
NYR34_RS03245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NYR34_RS03250	COG0275	rRNA processing
NYR34_RS03265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NYR34_RS03275	COG0482	sulfurtransferase activity
NYR34_RS03280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NYR34_RS03295	COG0346	lactoylglutathione lyase activity
NYR34_RS03300	COG0346	lactoylglutathione lyase activity
NYR34_RS03305	COG1846	Transcriptional regulator
NYR34_RS03310	COG0400	carboxylic ester hydrolase activity
NYR34_RS03350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NYR34_RS03505	COG0564	pseudouridine synthase activity
NYR34_RS03510	COG1187	pseudouridine synthase activity
NYR34_RS03515	COG1584	GPR1 FUN34 yaaH family protein
NYR34_RS03525	COG0765	amino acid transport
NYR34_RS03540	COG0300	oxidoreductase activity
NYR34_RS03545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NYR34_RS03555	COG0366	Alpha amylase catalytic
NYR34_RS03570	COG3833	ABC-type maltose transport systems, permease component
NYR34_RS03575	COG1175	transmembrane transport
NYR34_RS03580	COG2182	Extracellular solute-binding protein
NYR34_RS03600	COG2819	hydrolase of the alpha beta superfamily
NYR34_RS03605	COG1523	belongs to the glycosyl hydrolase 13 family
NYR34_RS03625	COG0366	Alpha amylase catalytic
NYR34_RS03640	COG0386	Belongs to the glutathione peroxidase family
NYR34_RS03645	COG1253	flavin adenine dinucleotide binding
NYR34_RS03680	COG0481	GTPase activity
NYR34_RS03690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NYR34_RS03695	COG4974	Belongs to the 'phage' integrase family
NYR34_RS03700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NYR34_RS03705	COG3763	UPF0154 protein
NYR34_RS03710	COG0742	ribosomal rna small subunit methyltransferase
NYR34_RS03725	COG0588	phosphoglycerate mutase activity
NYR34_RS03755	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NYR34_RS03760	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NYR34_RS03765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NYR34_RS03795	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NYR34_RS03805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NYR34_RS03810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NYR34_RS03815	COG1799	cell septum assembly
NYR34_RS03820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NYR34_RS03825	COG0012	GTP binding
NYR34_RS03830	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NYR34_RS03835	COG0343	queuine tRNA-ribosyltransferase activity
NYR34_RS03850	COG0778	Nitroreductase
NYR34_RS03855	COG1136	(ABC) transporter
NYR34_RS03855	COG0577	efflux transmembrane transporter activity
NYR34_RS03860	COG0577	efflux transmembrane transporter activity
NYR34_RS03860	COG1136	(ABC) transporter
NYR34_RS03870	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NYR34_RS03905	COG1230	cation diffusion facilitator family transporter
NYR34_RS03915	COG2030	dehydratase
NYR34_RS03955	COG1937	Protein conserved in bacteria
NYR34_RS03965	COG0446	pyridine nucleotide-disulphide oxidoreductase
NYR34_RS03970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NYR34_RS03995	COG1131	(ABC) transporter
NYR34_RS04010	COG1748	Saccharopine dehydrogenase
NYR34_RS04020	COG0656	L-ascorbic acid biosynthetic process
NYR34_RS04025	COG1363	Peptidase, m42
NYR34_RS04045	COG0133	tryptophan synthase activity
NYR34_RS04075	COG1215	transferase activity, transferring glycosyl groups
NYR34_RS04095	COG1114	Component of the transport system for branched-chain amino acids
NYR34_RS04100	COG2801	Transposase and inactivated derivatives
NYR34_RS04125	COG1473	amidohydrolase
NYR34_RS04130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NYR34_RS04135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NYR34_RS04140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NYR34_RS04150	COG0019	diaminopimelate decarboxylase activity
NYR34_RS04155	COG0737	Belongs to the 5'-nucleotidase family
NYR34_RS04165	COG0516	GMP reductase activity
NYR34_RS04185	COG1304	FMN binding
NYR34_RS04200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NYR34_RS04205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NYR34_RS04210	COG2313	pseudouridylate synthase activity
NYR34_RS04250	COG1185	polyribonucleotide nucleotidyltransferase activity
NYR34_RS04255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NYR34_RS04260	COG3870	Protein conserved in bacteria
NYR34_RS04265	COG0196	riboflavin kinase activity
NYR34_RS04270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NYR34_RS04275	COG3118	belongs to the thioredoxin family
NYR34_RS04285	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NYR34_RS04290	COG0564	pseudouridine synthase activity
NYR34_RS04295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NYR34_RS04305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NYR34_RS04310	COG2131	deaminase
NYR34_RS04320	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NYR34_RS04325	COG0124	histidyl-tRNA synthetase
NYR34_RS04335	COG0628	permease
NYR34_RS04340	COG1490	D-aminoacyl-tRNA deacylase activity
NYR34_RS04345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NYR34_RS04350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NYR34_RS04355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NYR34_RS04360	COG0047	phosphoribosylformylglycinamidine synthase activity
NYR34_RS04370	COG3331	DNA recombination
NYR34_RS04410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NYR34_RS04415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NYR34_RS04420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NYR34_RS04425	COG1132	(ABC) transporter
NYR34_RS04430	COG1132	(ABC) transporter
NYR34_RS04445	COG0006	proline dipeptidase activity
NYR34_RS04450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NYR34_RS04455	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NYR34_RS04460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NYR34_RS04465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NYR34_RS04470	COG0488	(ABC) transporter
NYR34_RS04480	COG2816	NAD+ diphosphatase activity
NYR34_RS04545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NYR34_RS04560	COG0776	regulation of translation
NYR34_RS04565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NYR34_RS04570	COG1160	GTP binding
NYR34_RS04575	COG0539	negative regulation of cytoplasmic translation
NYR34_RS04580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NYR34_RS04585	COG1187	pseudouridine synthase activity
NYR34_RS04590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NYR34_RS04595	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NYR34_RS04605	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NYR34_RS04610	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NYR34_RS04615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NYR34_RS04625	COG1692	metallophosphoesterase
NYR34_RS04630	COG4372	Transposase
NYR34_RS04630	COG1418	mRNA catabolic process
NYR34_RS04640	COG1132	(ABC) transporter
NYR34_RS04645	COG1132	(ABC) transporter
NYR34_RS04650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NYR34_RS04660	COG0268	Binds directly to 16S ribosomal RNA
NYR34_RS04665	COG2176	DNA-directed DNA polymerase activity
NYR34_RS04675	COG2333	competence protein COMEC
NYR34_RS04675	COG0658	competence protein
NYR34_RS04685	COG0799	negative regulation of ribosome biogenesis
NYR34_RS04690	COG1713	HD superfamily hydrolase involved in NAD metabolism
NYR34_RS04700	COG0647	UMP catabolic process
NYR34_RS04705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NYR34_RS04715	COG4122	O-methyltransferase activity
NYR34_RS04720	COG3906	Belongs to the UPF0473 family
NYR34_RS04725	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NYR34_RS04730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NYR34_RS04735	COG4536	flavin adenine dinucleotide binding
NYR34_RS04745	COG5001	Diguanylate cyclase
NYR34_RS04750	COG0475	glutathione-regulated potassium exporter activity
NYR34_RS04765	COG1307	EDD domain protein, DegV family
NYR34_RS04770	COG0275	rRNA processing
NYR34_RS04785	COG1823	symporter activity
NYR34_RS04840	COG3279	Response regulator of the LytR AlgR family
NYR34_RS04915	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NYR34_RS04925	COG3935	DnaD domain protein
NYR34_RS04940	COG4974	Belongs to the 'phage' integrase family
NYR34_RS04975	COG1132	(ABC) transporter
NYR34_RS04995	COG0358	DNA primase activity
NYR34_RS05000	COG0423	glycine-tRNA ligase activity
NYR34_RS05010	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NYR34_RS05015	COG0295	cytidine deaminase activity
NYR34_RS05020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NYR34_RS05025	COG1702	phosphate starvation-inducible protein PhoH
NYR34_RS05030	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NYR34_RS05040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NYR34_RS05045	COG4607	ABC-type enterochelin transport system periplasmic component
NYR34_RS05050	COG4604	ABC transporter, ATP-binding protein
NYR34_RS05055	COG4605	iron ion homeostasis
NYR34_RS05060	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NYR34_RS05075	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NYR34_RS05085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NYR34_RS05090	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NYR34_RS05095	COG2239	Acts as a magnesium transporter
NYR34_RS05100	COG2239	Acts as a magnesium transporter
NYR34_RS05115	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NYR34_RS05120	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NYR34_RS05125	COG2871	sodium ion transport
NYR34_RS05135	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
NYR34_RS05140	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
NYR34_RS05165	COG1269	ATP hydrolysis coupled proton transport
NYR34_RS05180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NYR34_RS05190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NYR34_RS05195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NYR34_RS05200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NYR34_RS05205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NYR34_RS05210	COG0356	it plays a direct role in the translocation of protons across the membrane
NYR34_RS05225	COG0312	modulator of DNA gyrase
NYR34_RS05230	COG0312	modulator of DNA gyrase
NYR34_RS05235	COG1132	(ABC) transporter
NYR34_RS05240	COG1132	(ABC) transporter
NYR34_RS05265	COG0667	Aldo Keto reductase
NYR34_RS05280	COG2011	ABC-type metal ion transport system permease component
NYR34_RS05285	COG1464	Belongs to the NlpA lipoprotein family
NYR34_RS05290	COG0668	transmembrane transport
NYR34_RS05370	COG1716	ATPase activity
NYR34_RS05370	COG5001	Diguanylate cyclase
NYR34_RS05395	COG0489	protein tyrosine kinase activity
NYR34_RS05415	COG0556	nucleotide-excision repair
NYR34_RS05480	COG2081	HI0933 family
NYR34_RS05485	COG0569	domain protein
NYR34_RS05490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NYR34_RS05530	COG0446	pyridine nucleotide-disulphide oxidoreductase
NYR34_RS05535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NYR34_RS05540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NYR34_RS05555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NYR34_RS05585	COG2801	Transposase and inactivated derivatives
NYR34_RS05615	COG2244	polysaccharide biosynthetic process
NYR34_RS05640	COG1442	glycosyl transferase family 8
NYR34_RS05640	COG1216	Glycosyl transferase, family 2
NYR34_RS05650	COG1086	Polysaccharide biosynthesis protein
NYR34_RS05660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NYR34_RS05700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NYR34_RS05720	COG0395	ABC-type sugar transport system, permease component
NYR34_RS05730	COG1653	transport
NYR34_RS05800	COG1061	Type III restriction enzyme res subunit
NYR34_RS05835	COG0205	6-phosphofructokinase activity
NYR34_RS05840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NYR34_RS05855	COG1902	pentaerythritol trinitrate reductase activity
NYR34_RS05865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NYR34_RS05870	COG1121	(ABC) transporter
NYR34_RS05880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NYR34_RS05890	COG0488	(ABC) transporter
NYR34_RS05895	COG1346	cytolysis
NYR34_RS05900	COG1380	Effector of murein hydrolase LrgA
NYR34_RS05910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NYR34_RS06005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NYR34_RS06060	COG2801	Transposase and inactivated derivatives
NYR34_RS06070	COG1054	Belongs to the UPF0176 family
NYR34_RS06095	COG5001	Diguanylate cyclase
NYR34_RS06115	COG2217	Heavy metal translocating P-type atpase
NYR34_RS06115	COG2608	mercury ion transmembrane transporter activity
NYR34_RS06150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NYR34_RS06190	COG0750	zinc metalloprotease
NYR34_RS06200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NYR34_RS06205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NYR34_RS06220	COG0233	cytoplasmic translational termination
NYR34_RS06225	COG0528	UMP kinase activity
NYR34_RS06230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NYR34_RS06235	COG0052	Belongs to the universal ribosomal protein uS2 family
NYR34_RS06245	COG0756	dUTP diphosphatase activity
NYR34_RS06250	COG4974	Belongs to the 'phage' integrase family
NYR34_RS06255	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NYR34_RS06260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NYR34_RS06275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NYR34_RS06285	COG1394	ATPase activity, coupled to movement of substances
NYR34_RS06315	COG1269	ATP hydrolysis coupled proton transport
NYR34_RS06340	COG1393	Belongs to the ArsC family
NYR34_RS06345	COG1164	Oligoendopeptidase f
NYR34_RS06350	COG0180	Tryptophanyl-tRNA synthetase
NYR34_RS06360	COG1597	lipid kinase activity
NYR34_RS06365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NYR34_RS06370	COG1609	Transcriptional regulator
NYR34_RS06375	COG0335	large ribosomal subunit rRNA binding
NYR34_RS06380	COG0336	Belongs to the RNA methyltransferase TrmD family
NYR34_RS06385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NYR34_RS06390	COG1837	Belongs to the UPF0109 family
NYR34_RS06395	COG0228	four-way junction DNA binding
NYR34_RS06405	COG1187	pseudouridine synthase activity
NYR34_RS06410	COG0242	peptide deformylase activity
NYR34_RS06425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NYR34_RS06430	COG0301	tRNA thio-modification
NYR34_RS06435	COG1956	GAF domain-containing protein
NYR34_RS06440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NYR34_RS06445	COG2801	Transposase and inactivated derivatives
NYR34_RS06470	COG3634	alkyl hydroperoxide reductase activity
NYR34_RS06485	COG0149	triose-phosphate isomerase activity
NYR34_RS06500	COG0126	phosphoglycerate kinase activity
NYR34_RS06520	COG0719	Fe-S assembly protein
NYR34_RS06525	COG0822	iron-sulfur transferase activity
NYR34_RS06530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NYR34_RS06535	COG0719	Fe-S assembly protein
NYR34_RS06540	COG0396	ATPase activity
NYR34_RS06560	COG0444	Belongs to the ABC transporter superfamily
NYR34_RS06565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NYR34_RS06570	COG0601	transmembrane transport
NYR34_RS06605	COG2801	Transposase and inactivated derivatives
NYR34_RS06610	COG2502	aspartate--ammonia ligase
NYR34_RS06655	COG1131	(ABC) transporter
NYR34_RS06660	COG1132	(ABC) transporter
NYR34_RS06705	COG0459	protein refolding
NYR34_RS06710	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NYR34_RS06730	COG1126	abc transporter atp-binding protein
NYR34_RS06740	COG1464	Belongs to the NlpA lipoprotein family
NYR34_RS06745	COG2011	ABC-type metal ion transport system permease component
NYR34_RS06750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NYR34_RS06765	COG2217	Heavy metal translocating P-type atpase
NYR34_RS06770	COG0640	Transcriptional regulator
NYR34_RS06785	COG0789	Transcriptional regulator
NYR34_RS06845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NYR34_RS06880	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NYR34_RS06885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NYR34_RS06895	COG4974	Belongs to the 'phage' integrase family
NYR34_RS06900	COG3620	sequence-specific DNA binding
NYR34_RS06905	COG2801	Transposase and inactivated derivatives
NYR34_RS06930	COG1396	sequence-specific DNA binding
NYR34_RS06940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NYR34_RS06945	COG3469	chitinase activity
NYR34_RS06950	COG3842	ATPase activity
NYR34_RS06955	COG1176	ABC-type spermidine putrescine transport system, permease component I
NYR34_RS06980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NYR34_RS06985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NYR34_RS06990	COG1780	Probably involved in ribonucleotide reductase function
NYR34_RS07020	COG5002	protein histidine kinase activity
NYR34_RS07025	COG0745	RESPONSE REGULATOR receiver
NYR34_RS07030	COG0704	Plays a role in the regulation of phosphate uptake
NYR34_RS07035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NYR34_RS07040	COG0581	inorganic phosphate transmembrane transporter activity
NYR34_RS07045	COG0573	inorganic phosphate transmembrane transporter activity
NYR34_RS07060	COG1131	(ABC) transporter
NYR34_RS07065	COG1597	lipid kinase activity
NYR34_RS07070	COG0095	Lipoate-protein ligase
NYR34_RS07100	COG2184	nucleotidyltransferase activity
NYR34_RS07115	COG0010	Belongs to the arginase family
NYR34_RS07120	COG1982	Orn Lys Arg decarboxylase major
NYR34_RS07145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NYR34_RS07145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NYR34_RS07160	COG3706	GGDEF domain
NYR34_RS07165	COG1012	belongs to the aldehyde dehydrogenase family
NYR34_RS07200	COG2183	response to ionizing radiation
NYR34_RS07210	COG0736	holo-[acyl-carrier-protein] synthase activity
NYR34_RS07220	COG0492	ferredoxin-NADP+ reductase activity
NYR34_RS07230	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NYR34_RS07240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NYR34_RS07245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NYR34_RS07275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NYR34_RS07285	COG1214	PFAM Peptidase M22, glycoprotease
NYR34_RS07290	COG0802	atpase or kinase
NYR34_RS07295	COG0166	Belongs to the GPI family
NYR34_RS07300	COG0539	negative regulation of cytoplasmic translation
NYR34_RS07315	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NYR34_RS07320	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NYR34_RS07345	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NYR34_RS07350	COG1733	regulation of RNA biosynthetic process
NYR34_RS07355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NYR34_RS07360	COG2252	PERMEase
NYR34_RS07365	COG2233	PERMEase
NYR34_RS07370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NYR34_RS07375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NYR34_RS07405	COG0424	maF-like protein
NYR34_RS07410	COG0037	tRNA processing
NYR34_RS07420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NYR34_RS07425	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NYR34_RS07430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NYR34_RS07465	COG0673	inositol 2-dehydrogenase activity
NYR34_RS07470	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NYR34_RS07480	COG0191	fructose-bisphosphate aldolase activity
NYR34_RS07485	COG0504	CTP synthase activity
NYR34_RS07505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NYR34_RS07510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NYR34_RS07515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NYR34_RS07520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NYR34_RS07525	COG1285	pathogenesis
NYR34_RS07530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NYR34_RS07535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NYR34_RS07560	COG0395	ABC-type sugar transport system, permease component
NYR34_RS07565	COG1175	transmembrane transport
NYR34_RS07585	COG1562	ergosterol biosynthetic process
NYR34_RS07595	COG0170	dolichyl monophosphate biosynthetic process
NYR34_RS07600	COG1136	(ABC) transporter
NYR34_RS07605	COG0577	efflux transmembrane transporter activity
NYR34_RS07610	COG0386	Belongs to the glutathione peroxidase family
NYR34_RS07615	COG3279	Response regulator of the LytR AlgR family
NYR34_RS07630	COG1307	EDD domain protein, DegV family
NYR34_RS07645	COG0017	Asparaginyl-tRNA synthetase
NYR34_RS07660	COG1847	R3H domain protein
NYR34_RS07665	COG0706	membrane insertase activity
NYR34_RS07670	COG0594	ribonuclease P activity
NYR34_RS07675	COG0230	Belongs to the bacterial ribosomal protein bL34 family