locus-tag class description FOC81_RS00145 ENOG4105C2W permease FOC81_RS00150 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FOC81_RS00190 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS00210 ENOG4105F27 Major Facilitator FOC81_RS00215 ENOG4105DJB Major Facilitator Superfamily FOC81_RS00220 ENOG4105CXK mandelate racemase muconate lactonizing FOC81_RS00225 ENOG4108RTU Aldolase FOC81_RS00230 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FOC81_RS00235 ENOG4107HP6 Transcriptional regulator FOC81_RS00240 ENOG4107RSM transcriptional regulator FOC81_RS00245 ENOG4105C26 Dehydrogenase FOC81_RS00260 ENOG4108TGY Glutathione S-transferase FOC81_RS00275 ENOG4105CRE cytochrome C FOC81_RS00280 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FOC81_RS00285 ENOG4109066 lysm domain bon superfamily protein FOC81_RS00295 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FOC81_RS00305 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FOC81_RS00320 ENOG4105NXH GreA GreB family elongation factor FOC81_RS00325 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC81_RS00345 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS00360 ENOG410846T CoA-transferase family III FOC81_RS00365 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS00375 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS00385 ENOG4108SF5 RNA Polymerase FOC81_RS00390 ENOG4108S3W Anti-feci sigma factor, fecr FOC81_RS00395 ENOG4105E0K tonB-dependent siderophore receptor FOC81_RS00400 ENOG4108SF5 RNA Polymerase FOC81_RS00405 ENOG4105E0K tonB-dependent siderophore receptor FOC81_RS00410 ENOG4105GZI Transcriptional regulator FOC81_RS00425 ENOG410846T CoA-transferase family III FOC81_RS00440 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS00455 ENOG4105F04 LysR family Transcriptional regulator FOC81_RS00465 ENOG4105VCQ rubredoxin FOC81_RS00490 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC81_RS00515 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FOC81_RS00520 ENOG4105ENR peptidase, M24 FOC81_RS00535 ENOG4105CXN decarboxylase FOC81_RS00540 ENOG4105CSW GntR family transcriptional regulator FOC81_RS00545 ENOG4105DJ4 phosphatidylserine decarboxylase FOC81_RS00550 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC81_RS00570 ENOG4105DFA alanine racemase domain protein FOC81_RS00580 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC81_RS00585 ENOG4105G3Z GntR family transcriptional regulator FOC81_RS00600 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC81_RS00610 ENOG4106NZI LysR family Transcriptional regulator FOC81_RS00615 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOC81_RS00630 ENOG4105DKK Benzoate FOC81_RS00635 ENOG4105F04 LysR family Transcriptional regulator FOC81_RS00650 ENOG4105CGP Urocanate hydratase FOC81_RS00660 ENOG4108TGY Glutathione S-transferase FOC81_RS00670 ENOG4108T2C cysteine dioxygenase type I FOC81_RS00675 ENOG4105C84 Histidine ammonia-lyase FOC81_RS00680 ENOG4105CH7 arginosuccinase FOC81_RS00700 ENOG4108WAV Transcriptional regulator FOC81_RS00710 ENOG4105C7F AcnD-accessory protein PrpF FOC81_RS00715 ENOG4108I0Z Aconitate hydratase FOC81_RS00730 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC81_RS00745 ENOG4108M0I Transcriptional regulator FOC81_RS00755 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC81_RS00760 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FOC81_RS00770 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC81_RS00785 ENOG4105CYM Glutathione S-transferase FOC81_RS00800 ENOG41079YP Citrate utilization protein b FOC81_RS00815 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC81_RS00825 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC81_RS00830 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC81_RS00835 ENOG4108KTG Membrane protein, drug metabolite transporter FOC81_RS00840 ENOG4105EXG Transcriptional regulator FOC81_RS00850 ENOG4105CMI transporter FOC81_RS00855 ENOG4105CJ1 ABC, transporter FOC81_RS00860 ENOG4105D0S secretion protein (HlyD FOC81_RS00865 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC81_RS00875 ENOG4105CXC rtn protein FOC81_RS00880 ENOG4107SVH Potassium channel protein FOC81_RS00885 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC81_RS00910 ENOG4105C72 UPF0176 protein FOC81_RS00915 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC81_RS00925 ENOG4105D1F ATP-binding protein FOC81_RS00940 ENOG4105DHP deoxycytidine triphosphate deaminase FOC81_RS00950 ENOG41064RH membrane protein YliF FOC81_RS00955 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC81_RS00965 ENOG4105CXN decarboxylase FOC81_RS00970 ENOG4105CBX hi0933 family FOC81_RS00975 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC81_RS00985 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FOC81_RS00990 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FOC81_RS00995 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FOC81_RS01010 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS01015 ENOG4108JQ6 ABC transporter FOC81_RS01040 ENOG4105C26 Dehydrogenase FOC81_RS01045 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC81_RS01050 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC81_RS01060 ENOG4105BZU Histidine kinase FOC81_RS01075 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) FOC81_RS01080 ENOG4107UKG Glycosyl transferase, family 4 FOC81_RS01085 ENOG4107QQG Dehydrogenase FOC81_RS01100 ENOG4105CG5 Glycosyl transferase (Group 1 FOC81_RS01110 ENOG4108KMV Glycosyl transferase (Group 1 FOC81_RS01115 ENOG4108KMV Glycosyl transferase (Group 1 FOC81_RS01125 ENOG4107QP8 phosphohexose isomerase FOC81_RS01140 ENOG4105CQB FAD linked oxidase domain protein FOC81_RS01145 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC81_RS01150 ENOG4108TAG Histidine kinase FOC81_RS01160 ENOG4105JXH GntR family transcriptional regulator FOC81_RS01165 ENOG4105E0M Sulfatase FOC81_RS01210 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC81_RS01215 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein FOC81_RS01220 ENOG41081V9 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) FOC81_RS01225 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS01230 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FOC81_RS01250 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC81_RS01260 ENOG4105C3G gtp-binding protein FOC81_RS01305 ENOG4105DKK Benzoate FOC81_RS01310 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FOC81_RS01315 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FOC81_RS01320 ENOG4106H78 methyltransferase FOC81_RS01350 ENOG4105D5T phosphonate abc transporter FOC81_RS01370 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOC81_RS01375 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FOC81_RS01380 ENOG4107YIM Involved in the transcription termination process (By similarity) FOC81_RS01385 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FOC81_RS01395 ENOG4107TH8 cina domain protein FOC81_RS01400 ENOG4105SKN orotidine 5''-phosphate decarboxylase FOC81_RS01405 ENOG4105CEP NADH dehydrogenase FOC81_RS01410 ENOG41080IJ Diacylglycerol kinase FOC81_RS01415 ENOG4105DEI Mannitol dehydrogenase FOC81_RS01430 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS01445 ENOG4108U05 Transcriptional regulator FOC81_RS01455 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FOC81_RS01460 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FOC81_RS01480 ENOG4107QZF nitrite reductase NADPH large subunit FOC81_RS01565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS01570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC81_RS01575 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC81_RS01600 ENOG410642W LysR family Transcriptional regulator FOC81_RS01605 ENOG4105C26 Dehydrogenase FOC81_RS01620 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS01630 ENOG4107GFK fumarate FOC81_RS01680 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC81_RS01685 ENOG4107EPV Aminotransferase class V FOC81_RS01695 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS01725 ENOG41088CQ domain protein FOC81_RS01730 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC81_RS01735 ENOG4105CY0 Metallo-Beta-Lactamase FOC81_RS01750 ENOG4105FGE Short-chain dehydrogenase reductase Sdr FOC81_RS01755 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme FOC81_RS01780 ENOG4105EQ0 Major Facilitator superfamily FOC81_RS01785 ENOG4105CR8 Transcriptional regulator FOC81_RS01800 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS01805 ENOG4106NZI LysR family Transcriptional regulator FOC81_RS01820 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC81_RS01825 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC81_RS01835 ENOG4108IV0 ABC, transporter FOC81_RS01840 ENOG4105C0Z ABC transporter FOC81_RS01850 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS01875 ENOG4108MGI Transcriptional regulator FOC81_RS01880 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FOC81_RS01885 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FOC81_RS01890 ENOG41080HI glycine oxidase FOC81_RS01895 ENOG4105CJP fad dependent oxidoreductase FOC81_RS01900 ENOG4105CDA abc transporter atp-binding protein FOC81_RS01905 ENOG4105E5Q amino acid AbC transporter FOC81_RS01910 ENOG4105EAB amino acid AbC transporter FOC81_RS01925 ENOG4105CGU Enoyl-CoA hydratase FOC81_RS01940 ENOG4108JQ7 (ABC) transporter FOC81_RS01945 ENOG4105C3U ABC transporter FOC81_RS01955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS01965 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS02000 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS02020 ENOG410829K Lysine exporter protein (Lyse ygga) FOC81_RS02035 ENOG4106IQC argininosuccinate lyase FOC81_RS02045 ENOG4105D2B acyl-CoA dehydrogenase FOC81_RS02050 ENOG4105CC9 acyl-Coa dehydrogenase FOC81_RS02055 ENOG4107QNJ CoA-transferase subunit B FOC81_RS02070 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FOC81_RS02075 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS02090 ENOG4105C5Q Transcriptional regulator FOC81_RS02115 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS02120 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC81_RS02130 ENOG4105CC9 acyl-Coa dehydrogenase FOC81_RS02145 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS02150 ENOG4105MP9 class II Aldolase FOC81_RS02195 ENOG4105EZR dyp-type peroxidase family protein FOC81_RS02200 ENOG4105CSU acyl-Coa dehydrogenase FOC81_RS02205 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS02220 ENOG4105BZU Histidine kinase FOC81_RS02225 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS02235 ENOG4105CNM Receptor FOC81_RS02245 ENOG4105CPC Aldo Keto reductase FOC81_RS02250 ENOG4105GRZ Ycii-related protein FOC81_RS02270 ENOG4108R3E Dna-3-methyladenine glycosylase i FOC81_RS02285 ENOG4107Y2X deaminase FOC81_RS02290 ENOG4105E5M Multidrug resistance protein D FOC81_RS02295 ENOG4105R1U AraC Family Transcriptional Regulator FOC81_RS02300 ENOG4108Z9W Outer membrane porin FOC81_RS02310 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FOC81_RS02315 ENOG4105CCU oxidase (Subunit III) FOC81_RS02320 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC81_RS02325 ENOG4105E2S oxidase) subunit II FOC81_RS02330 ENOG4105CSH Transporter FOC81_RS02335 ENOG4107QXX ABC transporter FOC81_RS02350 ENOG41067B5 Histone deacetylase superfamily protein FOC81_RS02375 ENOG41063Z6 transcriptional regulator, lysR family FOC81_RS02380 ENOG4105DU1 integral membrane protein, terc FOC81_RS02385 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FOC81_RS02390 ENOG4105R1U AraC Family Transcriptional Regulator FOC81_RS02395 ENOG4105DJ2 Major Facilitator Superfamily FOC81_RS02405 ENOG4105D4Y metalloprotease FOC81_RS02415 ENOG4105EPW hflc protein FOC81_RS02425 ENOG4108SF5 RNA Polymerase FOC81_RS02430 ENOG4108S3W Anti-feci sigma factor, fecr FOC81_RS02440 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC81_RS02450 ENOG4108I0Z Aconitate hydratase FOC81_RS02460 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FOC81_RS02465 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC81_RS02470 ENOG4108302 MgtC SapB transporter FOC81_RS02475 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC81_RS02490 ENOG4105CF1 Alkylated DNA repair protein FOC81_RS02495 ENOG4107RZC phospholipase d FOC81_RS02500 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein FOC81_RS02505 ENOG4108R6G acetyltransferase FOC81_RS02545 ENOG4108PCN EamA-like transporter family FOC81_RS02570 ENOG4105C6K Malic enzyme FOC81_RS02595 ENOG4105CHB tonB-dependent Receptor FOC81_RS02605 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FOC81_RS02610 ENOG4105CCU oxidase (Subunit III) FOC81_RS02615 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC81_RS02620 ENOG4105E2S oxidase) subunit II FOC81_RS02625 ENOG4108UYB regulatoR FOC81_RS02630 ENOG4105TX3 Histidine kinase FOC81_RS02645 ENOG4108ZX6 Electron transport protein SCO1 SenC FOC81_RS02650 ENOG4108K5P (LipO)protein FOC81_RS02665 ENOG4105EHG Permease protein FOC81_RS02670 ENOG4108W0P ABC transporter FOC81_RS02685 ENOG4105D05 Receptor FOC81_RS02695 ENOG4105CDA abc transporter atp-binding protein FOC81_RS02700 ENOG4105DRP amino acid AbC transporter FOC81_RS02705 ENOG4105EAB amino acid AbC transporter FOC81_RS02710 ENOG4105KXX peptidase s58 dmpa FOC81_RS02715 ENOG4108UT2 hemolysin iii FOC81_RS02720 ENOG4105F7P transcriptional regulator AsnC family FOC81_RS02735 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC81_RS02880 ENOG4105QIB mu-like prophage Flumu protein gp29 FOC81_RS02900 ENOG4105EFV Major head subunit FOC81_RS02910 ENOG4105Y5J prophage protein FOC81_RS02930 ENOG4105TKZ Tail Sheath FOC81_RS02970 ENOG4108T86 baseplate J family protein FOC81_RS02975 ENOG4105Y0G tail protein FOC81_RS03015 ENOG4108SF5 RNA Polymerase FOC81_RS03020 ENOG4108S3W Anti-feci sigma factor, fecr FOC81_RS03030 ENOG4106QJH hemin transport protein FOC81_RS03035 ENOG4107R4I Periplasmic binding protein FOC81_RS03040 ENOG4105EHG Permease protein FOC81_RS03050 ENOG4108VPT UPF0234 protein FOC81_RS03060 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC81_RS03065 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC81_RS03080 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC81_RS03105 ENOG4108IV0 ABC, transporter FOC81_RS03110 ENOG4105C0Z ABC transporter FOC81_RS03120 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS03125 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein FOC81_RS03160 ENOG41080E2 ribosomal-protein-alanine acetyltransferase FOC81_RS03165 ENOG4108UK5 Transposase FOC81_RS03185 ENOG4105CHR reductase FOC81_RS03205 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC81_RS03210 ENOG4105IFJ Histidine kinase FOC81_RS03225 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC81_RS03230 ENOG4106NZI LysR family Transcriptional regulator FOC81_RS03265 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC81_RS03270 ENOG4108IEG Formate dehydrogenase Alpha subunit FOC81_RS03275 ENOG4107QIZ NADH dehydrogenase FOC81_RS03290 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC81_RS03300 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC81_RS03305 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC81_RS03320 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC81_RS03330 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FOC81_RS03350 ENOG4108TZV Membrane FOC81_RS03355 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FOC81_RS03395 ENOG4107SET aldo keto reductase FOC81_RS03400 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FOC81_RS03405 ENOG4108JU5 Magnesium and cobalt efflux protein FOC81_RS03410 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FOC81_RS03415 ENOG4105C9A Phoh family FOC81_RS03420 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC81_RS03430 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC81_RS03440 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC81_RS03450 ENOG4105MHT Transcriptional regulator, ARSR family FOC81_RS03455 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC81_RS03460 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC81_RS03465 ENOG4105VIE preprotein translocase, subunit YajC FOC81_RS03470 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FOC81_RS03475 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FOC81_RS03490 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FOC81_RS03495 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FOC81_RS03510 ENOG4105TNS Conserved Protein FOC81_RS03525 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FOC81_RS03530 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FOC81_RS03545 ENOG4105C6K Malic enzyme FOC81_RS03560 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC81_RS03565 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOC81_RS03570 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC81_RS03575 ENOG4105BZA Phosphoglycerate kinase FOC81_RS03590 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FOC81_RS03595 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC81_RS03615 ENOG4108SHQ Glutathione S-transferase FOC81_RS03625 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) FOC81_RS03655 ENOG4105CJ3 phosphate transporter FOC81_RS03665 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC81_RS03675 ENOG4105DR5 peptidase FOC81_RS03685 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FOC81_RS03705 ENOG4105D5T phosphonate abc transporter FOC81_RS03710 ENOG4105EHI Phosphonate ABC transporter, periplasmic FOC81_RS03730 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC81_RS03735 ENOG410811B TRANSCRIPTIONal FOC81_RS03740 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FOC81_RS03745 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FOC81_RS03750 ENOG4105FD8 phosphonate metabolism protein PhnM FOC81_RS03755 ENOG4107RJJ Transcriptional regulator FOC81_RS03775 ENOG4105FT8 Phosphonate metabolism FOC81_RS03780 ENOG4105ENV phosphonate C-P lyase system protein PhnK FOC81_RS03785 ENOG4105HRV phosphonate c-p lyase system protein phnl FOC81_RS03790 ENOG4105FD8 phosphonate metabolism protein PhnM FOC81_RS03830 ENOG4107S4Y M20 DapE family protein YgeY FOC81_RS03845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS03870 ENOG4105C8V SAICAR synthetase FOC81_RS03880 ENOG4105RXK Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FOC81_RS03885 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC81_RS03890 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC81_RS03895 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC81_RS03900 ENOG4107HP6 Transcriptional regulator FOC81_RS03905 ENOG4107QNJ CoA-transferase subunit B FOC81_RS03920 ENOG4107QXX ABC transporter FOC81_RS03930 ENOG4105CYW agmatinase FOC81_RS03935 ENOG4106TNF Periplasmic binding protein FOC81_RS03940 ENOG4105E5Q amino acid AbC transporter FOC81_RS03945 ENOG4105CDA abc transporter atp-binding protein FOC81_RS03955 ENOG4105RQF LysR family Transcriptional regulator FOC81_RS03970 ENOG4105F38 ABC transporter, permease FOC81_RS03975 ENOG4108UMI ABC transporter, permease FOC81_RS03980 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS03985 ENOG4108IV0 ABC, transporter FOC81_RS03990 ENOG4105C0Z ABC transporter FOC81_RS03995 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS04000 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS04025 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOC81_RS04045 ENOG4108ZMQ domain protein FOC81_RS04060 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS04065 ENOG4105C7K acetolactate synthase FOC81_RS04070 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS04075 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC81_RS04080 ENOG4108Z66 YbaK ebsC protein FOC81_RS04100 ENOG41061WM D-Alanyl-D-Alanine FOC81_RS04115 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC81_RS04120 ENOG4107QN1 sodium solute FOC81_RS04145 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC81_RS04155 ENOG4107QMP dna polymerase iii subunits gamma and tau FOC81_RS04170 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS04175 ENOG4105D2X ABC transporter substrate-binding protein FOC81_RS04185 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC81_RS04195 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC81_RS04200 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FOC81_RS04205 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FOC81_RS04210 ENOG4105EMU Dehydrogenase FOC81_RS04215 ENOG4105CVJ phosphoglycerate mutase FOC81_RS04225 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS04235 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC FOC81_RS04245 ENOG4105C2W permease FOC81_RS04250 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS04255 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOC81_RS04260 ENOG4105HBR Rna-binding protein FOC81_RS04265 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FOC81_RS04270 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC81_RS04280 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FOC81_RS04290 ENOG4105C9X ppx gppa phosphatase FOC81_RS04300 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FOC81_RS04305 ENOG4105C8U phosphate abc transporter FOC81_RS04310 ENOG4105E2Z phosphate ABC transporter (Permease FOC81_RS04315 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS04345 ENOG4108SF5 RNA Polymerase FOC81_RS04360 ENOG4105E0K tonB-dependent siderophore receptor FOC81_RS04365 ENOG4105W5Q DNA repair protein (RadC FOC81_RS04400 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) FOC81_RS04410 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS04425 ENOG4105ERH Fumarylacetoacetate hydrolase FOC81_RS04430 ENOG4107XBN GntR Family Transcriptional Regulator FOC81_RS04460 ENOG4107HP6 Transcriptional regulator FOC81_RS04470 ENOG4105CNV Aldolase FOC81_RS04485 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC81_RS04500 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS04505 ENOG4108Z7G MaoC domain protein dehydratase FOC81_RS04525 ENOG4108UKI Enoyl-CoA hydratase FOC81_RS04530 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS04555 ENOG4107RUY (E1 component), alpha subunit FOC81_RS04560 ENOG4105CPP Dehydrogenase, E1 component FOC81_RS04565 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS04570 ENOG4105C7S Dehydrogenase FOC81_RS04590 ENOG41083Z3 extracellular ligand-binding receptor FOC81_RS04595 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS04600 ENOG4105C0Z ABC transporter FOC81_RS04605 ENOG4108IV0 ABC, transporter FOC81_RS04610 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC81_RS04620 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS04650 ENOG4105Z2P Protein of unknown function (DUF465) FOC81_RS04660 ENOG4105CHJ isochorismatase hydrolase FOC81_RS04665 ENOG4105CHJ isochorismatase hydrolase FOC81_RS04670 ENOG4105HEI LysR family (Transcriptional regulator FOC81_RS04680 ENOG4105DIQ Transcriptional regulator FOC81_RS04685 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase FOC81_RS04690 ENOG4105M4H endoribonuclease L-psp FOC81_RS04695 ENOG4105EAB amino acid AbC transporter FOC81_RS04710 ENOG4105E5Q amino acid AbC transporter FOC81_RS04720 ENOG4105CF7 AraC family transcriptional regulator FOC81_RS04725 ENOG4105CPC Aldo Keto reductase FOC81_RS04740 ENOG4105FQ6 thiopurine methyltransferase FOC81_RS04745 ENOG4105CHR reductase FOC81_RS04755 ENOG4108IV0 ABC, transporter FOC81_RS04760 ENOG4105C0Z ABC transporter FOC81_RS04765 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS04775 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC81_RS04780 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FOC81_RS04785 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme FOC81_RS04790 ENOG4105DCT glycerol dehydrogenase FOC81_RS04795 ENOG4108WYP Transcriptional regulator FOC81_RS04800 ENOG4108HHA Transketolase FOC81_RS04805 ENOG4108IUS Transketolase FOC81_RS04810 ENOG4105E2X shikimate dehydrogenase FOC81_RS04820 ENOG4105CTU Proline racemase FOC81_RS04825 ENOG4105D38 putrescine abc transporter FOC81_RS04830 ENOG4105F38 ABC transporter, permease FOC81_RS04835 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS04885 ENOG4105EGS Mechanosensitive ion channel FOC81_RS04890 ENOG4105CMU LysR family (Transcriptional regulator FOC81_RS04895 ENOG4105CYC Transferase FOC81_RS04900 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS04960 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FOC81_RS04970 ENOG4105C57 major facilitator superfamily FOC81_RS04980 ENOG4105EUF amidase EC 3.5.1.4 FOC81_RS04995 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FOC81_RS05010 ENOG4105C8T Leucyl-tRNA synthetase FOC81_RS05020 ENOG4108ZT1 Transcriptional regulator FOC81_RS05030 ENOG4105DZ1 carboxypeptidase FOC81_RS05050 ENOG4105C0Z ABC transporter FOC81_RS05065 ENOG4105W0E 50S ribosomal protein L33 FOC81_RS05070 ENOG4105KDC 50s ribosomal protein l28 FOC81_RS05075 ENOG4105C2C drug resistance transporter, Bcr CflA FOC81_RS05080 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC81_RS05090 ENOG4108HQS Glycine betaine FOC81_RS05095 ENOG4108IJ7 Glycine betaine FOC81_RS05100 ENOG41069HH 4-oxalocrotonate tautomerase FOC81_RS05115 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS05120 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS05125 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC81_RS05140 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC81_RS05165 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FOC81_RS05175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS05180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC81_RS05190 ENOG4105E7W lamb ycsf family protein FOC81_RS05200 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC81_RS05215 ENOG4107QX8 SPFH domain, Band 7 family protein FOC81_RS05230 ENOG4108SF5 RNA Polymerase FOC81_RS05235 ENOG4108S3W Anti-feci sigma factor, fecr FOC81_RS05245 ENOG4105E0K tonB-dependent siderophore receptor FOC81_RS05290 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS05305 ENOG4106NZI LysR family Transcriptional regulator FOC81_RS05310 ENOG4105D2B acyl-CoA dehydrogenase FOC81_RS05320 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS05325 ENOG410846T CoA-transferase family III FOC81_RS05330 ENOG4105C7B Threonine dehydratase FOC81_RS05335 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase FOC81_RS05345 ENOG4105DXI Major Facilitator superfamily FOC81_RS05355 ENOG4108ZIT Ferredoxin, 2FE-2S FOC81_RS05435 ENOG4108S8N class II Aldolase FOC81_RS05460 ENOG4105C26 Dehydrogenase FOC81_RS05470 ENOG4105F87 Dehydratase FOC81_RS05480 ENOG4105E5Q amino acid AbC transporter FOC81_RS05485 ENOG4105CJP fad dependent oxidoreductase FOC81_RS05500 ENOG4108P8G outer membrane autotransporter barrel FOC81_RS05510 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F FOC81_RS05515 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS05525 ENOG4105CHM Aminotransferase FOC81_RS05530 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC81_RS05540 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS05550 ENOG4108IUZ ABC transporter FOC81_RS05555 ENOG4108IV0 ABC, transporter FOC81_RS05560 ENOG4108WYP Transcriptional regulator FOC81_RS05570 ENOG4107R7A Allophanate hydrolase subunit 2 FOC81_RS05575 ENOG4105E7W lamb ycsf family protein FOC81_RS05580 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FOC81_RS05585 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC81_RS05600 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FOC81_RS05605 ENOG4105C26 Dehydrogenase FOC81_RS05615 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC81_RS05685 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC81_RS05700 ENOG4107QP8 phosphohexose isomerase FOC81_RS05710 ENOG4105D64 Mechanosensitive ion channel FOC81_RS05730 ENOG4105CEV competence damage-inducible protein FOC81_RS05745 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC81_RS05765 ENOG4105CHR reductase FOC81_RS05810 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC81_RS05820 ENOG4108PVQ transcriptional regulator FOC81_RS05840 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC81_RS05850 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS05860 ENOG4107QNJ CoA-transferase subunit B FOC81_RS05865 ENOG4105CC9 acyl-Coa dehydrogenase FOC81_RS05870 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC81_RS05895 ENOG41060WC Enoyl-CoA hydratase FOC81_RS05920 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC81_RS05955 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS05965 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS05990 ENOG4105DMF Dehydrogenase FOC81_RS06035 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS06055 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC81_RS06075 ENOG4107S01 Repressor protein MetJ FOC81_RS06120 ENOG4105CGZ zinc metallopeptidase FOC81_RS06125 ENOG4107RTD sua5 ycio yrdc ywlc family protein FOC81_RS06130 ENOG4108Z4T Peptidase M50 FOC81_RS06135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC81_RS06140 ENOG4105GJM (LipO)protein FOC81_RS06150 ENOG4105EZE Cupin 4 family protein FOC81_RS06155 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FOC81_RS06160 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS06175 ENOG4107RSM transcriptional regulator FOC81_RS06200 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC81_RS06205 ENOG4105EXG Transcriptional regulator FOC81_RS06215 ENOG4105WKW Pfam:DUF1458 FOC81_RS06235 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS06260 ENOG4105GVF (ABC) transporter FOC81_RS06280 ENOG4105C5I Dehydrogenase FOC81_RS06290 ENOG4105MP9 class II Aldolase FOC81_RS06320 ENOG4105D64 Mechanosensitive ion channel FOC81_RS06335 ENOG4105CVS RNA methyltransferase TrmH family, group 1 FOC81_RS06340 ENOG4105ECY inositol monophosphatase FOC81_RS06355 ENOG4108T0W nitrous oxide maturation protein NosY FOC81_RS06360 ENOG4105CIG ABC transporter FOC81_RS06370 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) FOC81_RS06375 ENOG4105HEE Binding Domain protein FOC81_RS06385 ENOG4105EE5 Membrane protein terC FOC81_RS06390 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC81_RS06400 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FOC81_RS06415 ENOG4105C8N cysteinyl-tRNA synthetase FOC81_RS06425 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FOC81_RS06435 ENOG4105CFH Aspartokinase FOC81_RS06445 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) FOC81_RS06470 ENOG4107HP6 Transcriptional regulator FOC81_RS06515 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC81_RS06520 ENOG4108T2C cysteine dioxygenase type I FOC81_RS06525 ENOG4105J4Q Transcriptional regulator FOC81_RS06555 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS06565 ENOG4105ERH Fumarylacetoacetate hydrolase FOC81_RS06570 ENOG4107YCY Transcriptional regulator FOC81_RS06590 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FOC81_RS06595 ENOG4105E0K tonB-dependent siderophore receptor FOC81_RS06615 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS06630 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS06645 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC81_RS06650 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS06655 ENOG4107QPN acyl-Coa dehydrogenase FOC81_RS06670 ENOG4105WH1 Two component transcriptional regulator luxr family FOC81_RS06675 ENOG4105WH1 Two component transcriptional regulator luxr family FOC81_RS06680 ENOG4106CD9 glycosyl transferase group 1 FOC81_RS06685 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF FOC81_RS06690 ENOG4106WTF Glycosyl transferase, family 2 FOC81_RS06695 ENOG4107T8Q Glycosyl transferase (Group 1 FOC81_RS06715 ENOG4105C30 Nad-dependent epimerase dehydratase FOC81_RS06720 ENOG4105C0K Gdp-mannose 4,6-dehydratase FOC81_RS06730 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FOC81_RS06735 ENOG4105FGF GDP-mannose mannosyl hydrolase FOC81_RS06740 ENOG4105D3Q Sugar transferase FOC81_RS06755 ENOG4107QKV phosphomannomutase FOC81_RS06760 ENOG4107QP8 phosphohexose isomerase FOC81_RS06765 ENOG4105CMR udp-glucose 4-epimerase FOC81_RS06770 ENOG4105D7W serine acetyltransferase FOC81_RS06775 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC81_RS06780 ENOG4105ECY inositol monophosphatase FOC81_RS06785 ENOG4105C26 Dehydrogenase FOC81_RS06790 ENOG4108JPW Aminotransferase FOC81_RS06810 ENOG4105D7N magnesium and cobalt transport protein CorA FOC81_RS06830 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS06835 ENOG4108JQ6 ABC transporter FOC81_RS06845 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FOC81_RS06860 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC81_RS06865 ENOG4107QM5 aconitate hydratase FOC81_RS06870 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS06880 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS06885 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC81_RS06890 ENOG4105C0Z ABC transporter FOC81_RS06895 ENOG4108IV0 ABC, transporter FOC81_RS06900 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FOC81_RS06920 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS06930 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS06950 ENOG4105C26 Dehydrogenase FOC81_RS06955 ENOG4105F04 LysR family Transcriptional regulator FOC81_RS06965 ENOG4107QIJ Aconitate hydratase 2 FOC81_RS06985 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC81_RS06995 ENOG4105DIA mandelate racemase muconate lactonizing FOC81_RS07000 ENOG4108IV0 ABC, transporter FOC81_RS07005 ENOG4105C0Z ABC transporter FOC81_RS07020 ENOG4105CP9 extracellular ligand-binding receptor FOC81_RS07025 ENOG4105CXK mandelate racemase muconate lactonizing FOC81_RS07030 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC81_RS07035 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS07045 ENOG4105CC9 acyl-Coa dehydrogenase FOC81_RS07050 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS07055 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FOC81_RS07060 ENOG4105WH1 Two component transcriptional regulator luxr family FOC81_RS07080 ENOG41080TK Universal stress protein FOC81_RS07085 ENOG4108YV4 Universal stress protein FOC81_RS07095 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS07120 ENOG4105CC9 acyl-Coa dehydrogenase FOC81_RS07135 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS07145 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS07150 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS07160 ENOG4105CPC Aldo Keto reductase FOC81_RS07170 ENOG4105C7J ABC transporter, permease FOC81_RS07175 ENOG4105D5T phosphonate abc transporter FOC81_RS07180 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC81_RS07215 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOC81_RS07220 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC81_RS07225 ENOG4105E0C molybdate abc transporter FOC81_RS07235 ENOG4105F4R Transcriptional regulator mode FOC81_RS07250 ENOG4105C1P efflux transporter, rnd family, mfp subunit FOC81_RS07255 ENOG4105BZS acriflavin resistance protein FOC81_RS07260 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC81_RS07265 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FOC81_RS07270 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) FOC81_RS07285 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC81_RS07295 ENOG4105CA0 peroxidase FOC81_RS07300 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FOC81_RS07325 ENOG4105CI0 Citrate lyase FOC81_RS07345 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FOC81_RS07355 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC81_RS07360 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC81_RS07375 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i FOC81_RS07395 ENOG4105C58 cytochrome c oxidase accessory protein ccog FOC81_RS07410 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC81_RS07425 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FOC81_RS07440 ENOG4105DA5 (ABC) transporter FOC81_RS07445 ENOG4105E3A (ABC) transporter FOC81_RS07470 ENOG4108UT2 hemolysin iii FOC81_RS07510 ENOG4108UQ8 endoribonuclease L-psp FOC81_RS07530 ENOG4108M0I Transcriptional regulator FOC81_RS07540 ENOG4108ZCF integral membrane protein FOC81_RS07560 ENOG4105EFX secretion protein, HlyD family FOC81_RS07575 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FOC81_RS07580 ENOG4108IYU L-aspartate oxidase FOC81_RS07590 ENOG4105ERH Fumarylacetoacetate hydrolase FOC81_RS07595 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC81_RS07600 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC81_RS07620 ENOG4105D01 (LipO)protein FOC81_RS07625 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS07630 ENOG4108UMI ABC transporter, permease FOC81_RS07645 ENOG4105CSR polyphosphate kinase 2 FOC81_RS07660 ENOG4105VEJ Heat shock protein FOC81_RS07685 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) FOC81_RS07695 ENOG4105CH2 amidohydrolase FOC81_RS07700 ENOG4105C57 major facilitator superfamily FOC81_RS07720 ENOG4105CVE Lytic murein transglycosylase FOC81_RS07740 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC81_RS07750 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS07765 ENOG4108JQ6 ABC transporter FOC81_RS07870 ENOG4105F7F Chaperone FOC81_RS07890 ENOG4108XM1 transcriptional regulator AsnC family FOC81_RS07905 ENOG4105CNM Receptor FOC81_RS07930 ENOG4108SY4 MarR family Transcriptional regulator FOC81_RS07940 ENOG4108IPT Naphthoate synthase FOC81_RS07950 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS07980 ENOG4105VRT cytoplasmic protein FOC81_RS07990 ENOG4105WPR Transcriptional regulator, ARAC family FOC81_RS07995 ENOG4105CNM Receptor FOC81_RS08010 ENOG4105R8A Heat shock protein FOC81_RS08015 ENOG4108YZ4 nudix hydrolase FOC81_RS08045 ENOG4105CSH Transporter FOC81_RS08055 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FOC81_RS08065 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC81_RS08070 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FOC81_RS08080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS08090 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS08095 ENOG4105MP9 class II Aldolase FOC81_RS08100 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS08115 ENOG4105C26 Dehydrogenase FOC81_RS08150 ENOG4105EQN UPF0261 protein FOC81_RS08165 ENOG4107RSM transcriptional regulator FOC81_RS08185 ENOG4105CJ2 (LipO)protein FOC81_RS08210 ENOG4108ARY Protein CrcB homolog FOC81_RS08225 ENOG4105FE1 phytoene synthase FOC81_RS08230 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC81_RS08235 ENOG4105CHR reductase FOC81_RS08240 ENOG4105F04 LysR family Transcriptional regulator FOC81_RS08245 ENOG4105MDS 4-oxalocrotonate tautomerase FOC81_RS08250 ENOG4105CNV Aldolase FOC81_RS08265 ENOG4105ERH Fumarylacetoacetate hydrolase FOC81_RS08270 ENOG4105C26 Dehydrogenase FOC81_RS08275 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase FOC81_RS08290 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC81_RS08305 ENOG4105C5I Dehydrogenase FOC81_RS08325 ENOG4107YCY Transcriptional regulator FOC81_RS08345 ENOG4105CNV Aldolase FOC81_RS08355 ENOG4105RQF LysR family Transcriptional regulator FOC81_RS08360 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) FOC81_RS08370 ENOG4105CJR Integral membrane protein (MviN FOC81_RS08385 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FOC81_RS08390 ENOG4105W49 UPF0434 protein FOC81_RS08400 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FOC81_RS08420 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC81_RS08425 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS08430 ENOG4105CMQ Chloride channel FOC81_RS08435 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS08445 ENOG4105VEQ Cold shock protein FOC81_RS08450 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FOC81_RS08455 ENOG4105DN3 alpha-2-macroglobulin domain protein FOC81_RS08460 ENOG4108JQB penicillin-binding protein 1C FOC81_RS08470 ENOG4105F1S paraquat-inducible protein a FOC81_RS08475 ENOG4105DY2 Paraquat-inducible protein b FOC81_RS08485 ENOG4105C26 Dehydrogenase FOC81_RS08495 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS08500 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC81_RS08505 ENOG4105C0Z ABC transporter FOC81_RS08510 ENOG4108IV0 ABC, transporter FOC81_RS08515 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS08520 ENOG4108UKI Enoyl-CoA hydratase FOC81_RS08530 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS08535 ENOG4105DCM major facilitator superfamily FOC81_RS08555 ENOG41080HT Transcriptional regulator, arsr family FOC81_RS08570 ENOG4108Z9K Osmotically inducible protein FOC81_RS08600 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC81_RS08615 ENOG4105CC0 LysR family Transcriptional regulator FOC81_RS08630 ENOG4106W5V Membrane FOC81_RS08645 ENOG4108VEV chaperone FOC81_RS08650 ENOG4105CW0 outer membrane usher protein FOC81_RS08670 ENOG4108D1Y Polypeptide-transport-associated domain protein, ShlB-type FOC81_RS08675 ENOG41068CG regulatoR FOC81_RS08685 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) FOC81_RS08705 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC81_RS08710 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FOC81_RS08715 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC81_RS08725 ENOG4105DTN riboflavin biosynthesis protein ribF FOC81_RS08730 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC81_RS08750 ENOG4105C4R Atp-dependent dna helicase FOC81_RS08760 ENOG4105C5H ABC transporter FOC81_RS08765 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FOC81_RS08775 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FOC81_RS08780 ENOG4105CHM Aminotransferase FOC81_RS08840 ENOG41076J9 exonuclease VIII FOC81_RS08955 ENOG4108TFU terminase (Small subunit) FOC81_RS09150 ENOG4105DJB Major Facilitator Superfamily FOC81_RS09155 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FOC81_RS09160 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC81_RS09185 ENOG4105DS1 cytochrome b561 FOC81_RS09190 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC81_RS09200 ENOG4105DY2 Paraquat-inducible protein b FOC81_RS09235 ENOG4105GZI Transcriptional regulator FOC81_RS09245 ENOG4105KME endoribonuclease L-psp FOC81_RS09275 ENOG4105VEQ Cold shock protein FOC81_RS09285 ENOG4105VEQ Cold shock protein FOC81_RS09295 ENOG4108TEB UPF0114 protein FOC81_RS09300 ENOG4108K0D peptidase, M48 FOC81_RS09305 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC81_RS09310 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC81_RS09315 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FOC81_RS09320 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FOC81_RS09325 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOC81_RS09350 ENOG4105CGF Aromatic amino acid aminotransferase FOC81_RS09355 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC81_RS09370 ENOG4105C3J Cysteine desulfurase FOC81_RS09375 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FOC81_RS09380 ENOG4108Z4V iron-sulfur cluster assembly FOC81_RS09385 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) FOC81_RS09390 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB FOC81_RS09395 ENOG4108ZIT Ferredoxin, 2FE-2S FOC81_RS09400 ENOG4105WVQ Fe-S assembly protein IscX FOC81_RS09405 ENOG4108Z5K methylglyoxal synthase FOC81_RS09410 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS09420 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS09430 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS09435 ENOG4105C0Z ABC transporter FOC81_RS09455 ENOG4108IV0 ABC, transporter FOC81_RS09460 ENOG4108IQE Amp-dependent synthetase and ligase FOC81_RS09465 ENOG4105F2C Acetyl-CoA acetyltransferase FOC81_RS09470 ENOG4108RZE Tetr family transcriptional regulator FOC81_RS09475 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS09485 ENOG4105EA8 2-Nitropropane dioxygenase FOC81_RS09495 ENOG4105C0A alcohol dehydrogenase FOC81_RS09500 ENOG4105C26 Dehydrogenase FOC81_RS09515 ENOG4105DXM phenylacetic acid degradation protein FOC81_RS09535 ENOG4105CRK lysyL-tRNA synthetase FOC81_RS09540 ENOG410904N short-chain dehydrogenase reductase FOC81_RS09550 ENOG4105CSP Major Facilitator Superfamily FOC81_RS09555 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC81_RS09570 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC81_RS09575 ENOG4105F8V Hydrolase, tatD family FOC81_RS09580 ENOG4105D05 Receptor FOC81_RS09585 ENOG4105E0F Histidine kinase FOC81_RS09590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC81_RS09595 ENOG4105D05 Receptor FOC81_RS09605 ENOG4105DHS permease protein FOC81_RS09610 ENOG4105CM4 permease protein FOC81_RS09615 ENOG4108IPW abc transporter atp-binding protein FOC81_RS09625 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS09630 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS09635 ENOG4108IYU L-aspartate oxidase FOC81_RS09640 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS09655 ENOG4105C7K acetolactate synthase FOC81_RS09660 ENOG4108EC8 DNA internalization-related competence protein ComEC FOC81_RS09675 ENOG4105CYM Glutathione S-transferase FOC81_RS09680 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS09710 ENOG4105C0A alcohol dehydrogenase FOC81_RS09715 ENOG4105DG4 malate L-lactate dehydrogenase FOC81_RS09725 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS09740 ENOG4105CHR reductase FOC81_RS09750 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FOC81_RS09760 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FOC81_RS09770 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS09775 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOC81_RS09800 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC81_RS09805 ENOG4105D9P serine threonine protein kinase FOC81_RS09810 ENOG4105TMB Formate nitrite transporter FOC81_RS09815 ENOG4107QZF nitrite reductase NADPH large subunit FOC81_RS09820 ENOG4107QZF nitrite reductase NADPH large subunit FOC81_RS09825 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS09835 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC81_RS09845 ENOG4105DB7 PHP domain protein FOC81_RS09850 ENOG4108RRZ Transcription elongation factor GreB FOC81_RS09855 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOC81_RS09860 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS09870 ENOG4108ETH Formylglycinamide ribotide synthetase FOC81_RS09885 ENOG4105C5Q Transcriptional regulator FOC81_RS09905 ENOG4105C26 Dehydrogenase FOC81_RS09910 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC81_RS09915 ENOG4105E0K tonB-dependent siderophore receptor FOC81_RS09920 ENOG4108S3W Anti-feci sigma factor, fecr FOC81_RS09930 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS09985 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC81_RS10000 ENOG4105DND Transcriptional regulator FOC81_RS10020 ENOG4108M9J MaoC like domain protein FOC81_RS10030 ENOG4108W2Y isochorismatase FOC81_RS10060 ENOG4105F4K antigen 43 FOC81_RS10065 ENOG4105DMF Dehydrogenase FOC81_RS10075 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC81_RS10080 ENOG4105C01 Dihydroxy-acid dehydratase FOC81_RS10090 ENOG4105CSP Major Facilitator Superfamily FOC81_RS10095 ENOG4105DDW LysR family Transcriptional regulator FOC81_RS10100 ENOG4108NVI FOC81_RS10105 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS10110 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS10135 ENOG4105BZU Histidine kinase FOC81_RS10145 ENOG4108UVJ appr-1-p processing domain protein FOC81_RS10170 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein FOC81_RS10205 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS10215 ENOG4105C3U ABC transporter FOC81_RS10220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS10225 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC81_RS10230 ENOG4105E1J oxidoreductase FOC81_RS10280 ENOG4108VP3 Lysine exporter protein (LysE YggA) FOC81_RS10290 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC81_RS10295 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC81_RS10405 ENOG4105BZ1 (ABC) transporter FOC81_RS10425 ENOG4105GZI Transcriptional regulator FOC81_RS10445 ENOG4105ECY inositol monophosphatase FOC81_RS10450 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS10470 ENOG4105CH6 catalase FOC81_RS10480 ENOG4105CAF HipA N-terminal domain protein FOC81_RS10495 ENOG4105CPQ Dehydrogenase FOC81_RS10500 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC81_RS10505 ENOG4105HKX acetone carboxylase, gamma subunit FOC81_RS10510 ENOG4107TYC hydantoinase B oxoprolinase FOC81_RS10515 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) FOC81_RS10530 ENOG4105DDW LysR family Transcriptional regulator FOC81_RS10550 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS10555 ENOG4107VFR oxidoreductase FOC81_RS10570 ENOG4105CWC Acetylornithine deacetylase FOC81_RS10595 ENOG4105F2V VRR-NUC domain-containing protein FOC81_RS10600 ENOG4105DVT helicase FOC81_RS10610 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS10615 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS10620 ENOG4108V3W Chemotaxis protein, CheW FOC81_RS10625 ENOG4108KTQ Methyltransferase FOC81_RS10635 ENOG4105CBS Chea signal transduction histidine kinase FOC81_RS10640 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FOC81_RS10650 ENOG4105F7P transcriptional regulator AsnC family FOC81_RS10665 ENOG4108KSA LysR family transcriptional regulator FOC81_RS10675 ENOG4105HEI LysR family (Transcriptional regulator FOC81_RS10695 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS10700 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS10705 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS10710 ENOG4105CC9 acyl-Coa dehydrogenase FOC81_RS10715 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS10720 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC81_RS10725 ENOG4105CBN LysR family transcriptional regulator FOC81_RS10730 ENOG4105C6Z Gluconate FOC81_RS10735 ENOG4106BRA Membrane FOC81_RS10740 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC81_RS10755 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC81_RS10770 ENOG4108ZG0 Ompa motb domain protein FOC81_RS10795 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC81_RS10800 ENOG4105DHQ Histidine kinase FOC81_RS10820 ENOG4105CH5 extracellular solute-binding protein, family 7 FOC81_RS10830 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS10850 ENOG41082F9 transcriptional regulator FOC81_RS10865 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS10875 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FOC81_RS10880 ENOG4105DXC membrane FOC81_RS10890 ENOG4105CHP RNA polymerase FOC81_RS10900 ENOG4105GRZ Ycii-related protein FOC81_RS10905 ENOG4105GRZ Ycii-related protein FOC81_RS10920 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FOC81_RS10970 ENOG4107R0U MotA TolQ exbB proton channel FOC81_RS10985 ENOG4105R1U AraC Family Transcriptional Regulator FOC81_RS10995 ENOG4105EWC Purine nucleoside phosphorylase FOC81_RS11020 ENOG4105PF9 Transcriptional regulator FOC81_RS11030 ENOG4105VMP Transcriptional regulator FOC81_RS11050 ENOG4105C3U ABC transporter FOC81_RS11055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS11060 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC81_RS11070 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS11075 ENOG4105C5R Aminotransferase FOC81_RS11085 ENOG4105CPC Aldo Keto reductase FOC81_RS11090 ENOG4105CSH Transporter FOC81_RS11100 ENOG4108FUF Transcriptional regulator, IclR family FOC81_RS11105 ENOG4108PVQ transcriptional regulator FOC81_RS11115 ENOG4105CH2 amidohydrolase FOC81_RS11130 ENOG4108SF5 RNA Polymerase FOC81_RS11140 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC81_RS11165 ENOG4105C0Z ABC transporter FOC81_RS11170 ENOG4105C2J ABC transporter FOC81_RS11175 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein FOC81_RS11185 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FOC81_RS11205 ENOG4105CNM Receptor FOC81_RS11210 ENOG4108S3W Anti-feci sigma factor, fecr FOC81_RS11220 ENOG4108RH0 Crea protein FOC81_RS11230 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FOC81_RS11235 ENOG4107ZSV Receptor FOC81_RS11245 ENOG4108SF5 RNA Polymerase FOC81_RS11260 ENOG4105D74 hydrolase FOC81_RS11265 ENOG41062ES Transcriptional regulator FOC81_RS11280 ENOG4105E0K tonB-dependent siderophore receptor FOC81_RS11290 ENOG4105JSC dimethylmenaquinone methyltransferase FOC81_RS11300 ENOG4105EAB amino acid AbC transporter FOC81_RS11305 ENOG4105EAD ABC transporter FOC81_RS11310 ENOG4105DRP amino acid AbC transporter FOC81_RS11315 ENOG4105CDA abc transporter atp-binding protein FOC81_RS11330 ENOG4105P8F nudix hydrolase FOC81_RS11335 ENOG4105C0B DNA polymerase III (alpha subunit) FOC81_RS11350 ENOG4108IQI permease FOC81_RS11355 ENOG4106KED esterase YpfH FOC81_RS11360 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FOC81_RS11365 ENOG4105C26 Dehydrogenase FOC81_RS11370 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) FOC81_RS11375 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) FOC81_RS11385 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS11390 ENOG4108IV0 ABC, transporter FOC81_RS11395 ENOG4105C0Z ABC transporter FOC81_RS11415 ENOG4105Y49 secretion protein, HlyD family FOC81_RS11420 ENOG4105ZQC membrane protein AaeX FOC81_RS11440 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC81_RS11445 ENOG4108YZN class I peptide chain release factor FOC81_RS11455 ENOG4107RSM transcriptional regulator FOC81_RS11465 ENOG4105EUF amidase EC 3.5.1.4 FOC81_RS11475 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC81_RS11520 ENOG4107QWP ABC-2 type transporter FOC81_RS11525 ENOG4105CJ1 ABC, transporter FOC81_RS11535 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FOC81_RS11540 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FOC81_RS11550 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC81_RS11560 ENOG4105E98 transcriptional regulator DeoR family FOC81_RS11565 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS11570 ENOG4108IJ9 (ABC) transporter FOC81_RS11595 ENOG4108JU3 Alkyl hydroperoxide reductase FOC81_RS11600 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC81_RS11605 ENOG4105BZP glycoside hydrolase 15-related FOC81_RS11610 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS11635 ENOG4105EW9 transcriptional regulator AsnC family FOC81_RS11640 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC81_RS11645 ENOG4107RH8 nuclease SbcCD subunit D FOC81_RS11670 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS11675 ENOG4105D65 subunit l FOC81_RS11680 ENOG4108ZE9 Monovalent cation H antiporter subunit C FOC81_RS11685 ENOG4107R4Z monovalent cation h antiporter subunit d FOC81_RS11690 ENOG4105SC1 monovalent cation H antiporter subunit E FOC81_RS11695 ENOG4105W4C monovalent cation H antiporter subunit F FOC81_RS11710 ENOG4106TCE FOC81_RS11715 ENOG4108Z6B deaminase FOC81_RS11720 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC81_RS11725 ENOG4105GZI Transcriptional regulator FOC81_RS11730 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS11740 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FOC81_RS11745 ENOG4105C5H ABC transporter FOC81_RS11780 ENOG41080RH Thioredoxin FOC81_RS11785 ENOG4105DEN Luciferase family FOC81_RS11790 ENOG4105C7N Xanthine uracil vitamin C permease FOC81_RS11795 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC81_RS11800 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC81_RS11815 ENOG4108K5P (LipO)protein FOC81_RS11835 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC81_RS11850 ENOG4105EHV domain protein FOC81_RS11860 ENOG4105D6S protein involved in catabolism of external DNA FOC81_RS11865 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FOC81_RS11875 ENOG4105EIN peptidylprolyl cis-trans isomerase FOC81_RS11880 ENOG4108UJV acyl-CoA thioesterase i FOC81_RS11885 ENOG4108I0Y (ABC) transporter FOC81_RS11895 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component FOC81_RS11900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS11905 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS11910 ENOG4105EAC phosphoserine phosphatase FOC81_RS11920 ENOG4105RKW reductase (By FOC81_RS11930 ENOG4105DND Transcriptional regulator FOC81_RS11945 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS11960 ENOG4105DND Transcriptional regulator FOC81_RS11965 ENOG4105CFM UPF0317 protein FOC81_RS11975 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS11985 ENOG4105C0Z ABC transporter FOC81_RS11990 ENOG4108IV0 ABC, transporter FOC81_RS11995 ENOG4108Z9W Outer membrane porin FOC81_RS12000 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS12035 ENOG4107R0W ABC transporter FOC81_RS12040 ENOG4105E5Q amino acid AbC transporter FOC81_RS12045 ENOG4105CDA abc transporter atp-binding protein FOC81_RS12050 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC81_RS12055 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FOC81_RS12060 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FOC81_RS12075 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC81_RS12080 ENOG4105K4H Nlp p60 protein FOC81_RS12085 ENOG4105FYV Amp nucleosidase FOC81_RS12090 ENOG4108IQI permease FOC81_RS12120 ENOG4105DSJ YicC domain protein FOC81_RS12125 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FOC81_RS12135 ENOG4105C0A alcohol dehydrogenase FOC81_RS12155 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC81_RS12160 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FOC81_RS12175 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS12185 ENOG4105BZU Histidine kinase FOC81_RS12190 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOC81_RS12195 ENOG4105CSA Coproporphyrinogen iii oxidase FOC81_RS12205 ENOG4105CUX Signal transduction histidine kinase FOC81_RS12210 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC81_RS12215 ENOG4105EQ1 Transcriptional regulator FOC81_RS12225 ENOG4105EUB pirin domain protein FOC81_RS12235 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS12240 ENOG4107RCV ABC transporter, permease FOC81_RS12250 ENOG4105DP0 ferredoxin-NADP reductase FOC81_RS12265 ENOG4105CHR reductase FOC81_RS12270 ENOG4105CHR reductase FOC81_RS12295 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS12300 ENOG4105KME endoribonuclease L-psp FOC81_RS12305 ENOG4105CB5 ATP-dependent DNA helicase recG FOC81_RS12310 ENOG4105C5Q Transcriptional regulator FOC81_RS12330 ENOG4105K64 Glycosyl transferase, family 2 FOC81_RS12350 ENOG4107TAE Glycosyl transferase (Group 1 FOC81_RS12360 ENOG4107QQG Dehydrogenase FOC81_RS12365 ENOG4105E12 capsule polysaccharide FOC81_RS12370 ENOG41084CK capsule polysaccharide FOC81_RS12375 ENOG4108W6C Dehydrogenase FOC81_RS12385 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC81_RS12400 ENOG4105CP9 extracellular ligand-binding receptor FOC81_RS12405 ENOG4107EXC regulatoR FOC81_RS12410 ENOG4105JJR Histidine kinase FOC81_RS12420 ENOG4108IJ9 (ABC) transporter FOC81_RS12430 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FOC81_RS12435 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC81_RS12440 ENOG4105II7 pyrroline-5-carboxylate reductase FOC81_RS12445 ENOG4105EX9 Membrane FOC81_RS12460 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS12465 ENOG4105DND Transcriptional regulator FOC81_RS12470 ENOG4105CP9 extracellular ligand-binding receptor FOC81_RS12475 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS12480 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC81_RS12485 ENOG4105C0Z ABC transporter FOC81_RS12490 ENOG4108IV0 ABC, transporter FOC81_RS12495 ENOG4105CG9 aspartate racemase FOC81_RS12515 ENOG4108K3A Glutathione S-transferase FOC81_RS12520 ENOG4105D8V Glucose sorbosone dehydrogenase FOC81_RS12530 ENOG4105DJP Membrane FOC81_RS12565 ENOG4105CYW agmatinase FOC81_RS12570 ENOG4105C8Y Acetylornithine aminotransferase FOC81_RS12575 ENOG4105D01 (LipO)protein FOC81_RS12580 ENOG4105BZU Histidine kinase FOC81_RS12595 ENOG4107RN3 metallophosphoesterase FOC81_RS12605 ENOG4105DJ4 phosphatidylserine decarboxylase FOC81_RS12620 ENOG4105C5H ABC transporter FOC81_RS12625 ENOG41061WM D-Alanyl-D-Alanine FOC81_RS12650 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC81_RS12655 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOC81_RS12660 ENOG4108NJZ Sensory box GGDEF EAL domain protein FOC81_RS12665 ENOG4105E3J oxidoreductase FOC81_RS12680 ENOG4105D94 Major Facilitator Superfamily FOC81_RS12685 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) FOC81_RS12700 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC81_RS12705 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC81_RS12710 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC81_RS12740 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC81_RS12745 ENOG4105DQE DNA ligase FOC81_RS12750 ENOG4105FDF Could be involved in DNA repair (By similarity) FOC81_RS12785 ENOG4105C5I Dehydrogenase FOC81_RS12800 ENOG4105BZU Histidine kinase FOC81_RS12815 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FOC81_RS12825 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FOC81_RS12830 ENOG4105CG3 alpha amylase, catalytic region FOC81_RS12835 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) FOC81_RS12840 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FOC81_RS12865 ENOG4107UXM Membrane FOC81_RS12870 ENOG4105DZQ phospholipase D Transphosphatidylase FOC81_RS12875 ENOG4105X23 Endonuclease Exonuclease phosphatase FOC81_RS12880 ENOG4108JQ6 ABC transporter FOC81_RS12895 ENOG4105EE5 Membrane protein terC FOC81_RS12905 ENOG4105SB3 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC81_RS12920 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FOC81_RS12930 ENOG4108IPT Naphthoate synthase FOC81_RS12985 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) FOC81_RS12995 ENOG4105IPI Membrane FOC81_RS13015 ENOG4108XM1 transcriptional regulator AsnC family FOC81_RS13030 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC81_RS13045 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS13080 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC81_RS13090 ENOG4105CD5 CoA-binding domain protein FOC81_RS13095 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS13100 ENOG4108Z40 Transcriptional regulator FOC81_RS13130 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS13145 ENOG4105EA8 2-Nitropropane dioxygenase FOC81_RS13150 ENOG4107QNJ CoA-transferase subunit B FOC81_RS13160 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FOC81_RS13165 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS13170 ENOG4108K8U Glycerol operon regulatory protein FOC81_RS13180 ENOG4108K3A Glutathione S-transferase FOC81_RS13200 ENOG41061MD high-affinity nickel-transporter FOC81_RS13205 ENOG4105VPX protein, conserved in bacteria FOC81_RS13220 ENOG4108YZG isomerase FOC81_RS13225 ENOG4105CAU Arsenical resistance protein, ArsH FOC81_RS13235 ENOG4105D6J arsenicaL-resistance protein FOC81_RS13255 ENOG4105FVZ flavin reductase domain protein, FMN-binding FOC81_RS13265 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC81_RS13275 ENOG4105DZ2 Transcriptional regulator FOC81_RS13290 ENOG4105MXW flavin reductase domain protein, FMN-binding FOC81_RS13320 ENOG4105KHC sulfurtransferase FOC81_RS13335 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FOC81_RS13340 ENOG4105CQB FAD linked oxidase domain protein FOC81_RS13345 ENOG41069M3 Transcriptional regulator FOC81_RS13370 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FOC81_RS13375 ENOG4105CSH Transporter FOC81_RS13385 ENOG4106NZI LysR family Transcriptional regulator FOC81_RS13390 ENOG4108YYC ycei family FOC81_RS13395 ENOG4105CHJ isochorismatase hydrolase FOC81_RS13405 ENOG4105CMJ mandelate racemase muconate lactonizing FOC81_RS13415 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC81_RS13425 ENOG4105ETE Transcriptional regulator (LacI family FOC81_RS13445 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS13455 ENOG4108PVQ transcriptional regulator FOC81_RS13460 ENOG4105DND Transcriptional regulator FOC81_RS13470 ENOG4105CI0 Citrate lyase FOC81_RS13475 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS13480 ENOG4105CC0 LysR family Transcriptional regulator FOC81_RS13555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS13580 ENOG4105CSP Major Facilitator Superfamily FOC81_RS13605 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS13615 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS13645 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS13655 ENOG4105C7K acetolactate synthase FOC81_RS13660 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FOC81_RS13665 ENOG4105C26 Dehydrogenase FOC81_RS13675 ENOG4105MP9 class II Aldolase FOC81_RS13685 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS13715 ENOG4105C7B Threonine dehydratase FOC81_RS13720 ENOG4105E9K Isocitrate dehydrogenase FOC81_RS13735 ENOG4108IJ6 ABC transporter FOC81_RS13740 ENOG4105CDA abc transporter atp-binding protein FOC81_RS13745 ENOG4105E5Q amino acid AbC transporter FOC81_RS13750 ENOG4105EAB amino acid AbC transporter FOC81_RS13770 ENOG4105E5Q amino acid AbC transporter FOC81_RS13775 ENOG4105CYW agmatinase FOC81_RS13780 ENOG4105CDA abc transporter atp-binding protein FOC81_RS13785 ENOG4105KME endoribonuclease L-psp FOC81_RS13790 ENOG4105CWC Acetylornithine deacetylase FOC81_RS13795 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC81_RS13805 ENOG4105EVZ LysR family transcriptional regulator FOC81_RS13810 ENOG4105CMQ Chloride channel FOC81_RS13830 ENOG4108ZXC Two component transcriptional regulator, luxr family FOC81_RS13835 ENOG4105CC9 acyl-Coa dehydrogenase FOC81_RS13855 ENOG4107RSM transcriptional regulator FOC81_RS13875 ENOG4107R11 Transcriptional regulator FOC81_RS13895 ENOG4105CDA abc transporter atp-binding protein FOC81_RS13905 ENOG4105E5Q amino acid AbC transporter FOC81_RS13925 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS13935 ENOG4105DMF Dehydrogenase FOC81_RS13945 ENOG4105JSC dimethylmenaquinone methyltransferase FOC81_RS13950 ENOG4108JQ1 Dehydrogenase FOC81_RS13970 ENOG4108ZHJ Organic hydroperoxide resistance protein FOC81_RS13975 ENOG4105EJC lysr family transcriptional regulator FOC81_RS13985 ENOG4108KPJ rna polymerase sigma factor FOC81_RS13990 ENOG4108KB2 LysR family Transcriptional regulator FOC81_RS13995 ENOG4105DTQ mandelate racemase muconate lactonizing FOC81_RS14010 ENOG4105JSC dimethylmenaquinone methyltransferase FOC81_RS14035 ENOG4105I5W Transporter FOC81_RS14040 ENOG4105D7T ABC transporter FOC81_RS14070 ENOG4105C9B Cysteine desulfurase FOC81_RS14075 ENOG4107QXX ABC transporter FOC81_RS14080 ENOG4105EZ7 amino acid ABC transporter FOC81_RS14100 ENOG4105WH1 Two component transcriptional regulator luxr family FOC81_RS14105 ENOG4105BZU Histidine kinase FOC81_RS14110 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FOC81_RS14115 ENOG4107B2H carbonic anhydrase FOC81_RS14120 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC81_RS14125 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FOC81_RS14130 ENOG41076YT nitrate reductase, gamma subunit FOC81_RS14135 ENOG4105R3A Nitrate reductase FOC81_RS14140 ENOG4108IUE nitrate reductase beta subunit FOC81_RS14145 ENOG4105CRU nitrate reductase, alpha subunit FOC81_RS14150 ENOG4105DQQ Major facilitator superfamily MFS_1 FOC81_RS14210 ENOG4105ENT Efflux transporter rnd family, mfp subunit FOC81_RS14215 ENOG4105BZS acriflavin resistance protein FOC81_RS14220 ENOG4105BZS acriflavin resistance protein FOC81_RS14225 ENOG4105C5Q Transcriptional regulator FOC81_RS14240 ENOG4105CH6 catalase FOC81_RS14260 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC81_RS14275 ENOG4105EA8 2-Nitropropane dioxygenase FOC81_RS14290 ENOG4105BZU Histidine kinase FOC81_RS14295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC81_RS14300 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) FOC81_RS14305 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FOC81_RS14315 ENOG4105E0X reductase FOC81_RS14320 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC81_RS14330 ENOG4105ES4 Nitrilase FOC81_RS14335 ENOG4108IV0 ABC, transporter FOC81_RS14350 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS14365 ENOG4106NZI LysR family Transcriptional regulator FOC81_RS14385 ENOG4105VCD cytoplasmic protein FOC81_RS14390 ENOG4105D22 carbon starvation protein FOC81_RS14405 ENOG4105EUJ GTP cyclohydrolase i FOC81_RS14410 ENOG4106FTQ Taurine ABC transporter, periplasmic FOC81_RS14420 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC81_RS14430 ENOG4105CJP fad dependent oxidoreductase FOC81_RS14445 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC81_RS14460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS14465 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC81_RS14470 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS14485 ENOG4108FUF Transcriptional regulator, IclR family FOC81_RS14490 ENOG4105C1J atp-dependent rna helicase FOC81_RS14515 ENOG410846T CoA-transferase family III FOC81_RS14520 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC81_RS14525 ENOG4105WAP TPR repeat-containing protein FOC81_RS14540 ENOG4105F27 Major Facilitator FOC81_RS14550 ENOG4108YXU transcriptional regulator AsnC family FOC81_RS14560 ENOG4105CYM Glutathione S-transferase FOC81_RS14575 ENOG4105DF9 Lipoate-protein, ligase FOC81_RS14585 ENOG4108Z9W Outer membrane porin FOC81_RS14590 ENOG4105D82 Glutamate dehydrogenase FOC81_RS14595 ENOG41088SP formiminoglutamate hydrolase FOC81_RS14600 ENOG4105CDA abc transporter atp-binding protein FOC81_RS14605 ENOG4105E5Q amino acid AbC transporter FOC81_RS14610 ENOG4106PMH Extracellular solute-binding protein family 3 FOC81_RS14620 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS14625 ENOG4108IV0 ABC, transporter FOC81_RS14630 ENOG4108IUZ ABC transporter FOC81_RS14635 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC81_RS14650 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS14655 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS14665 ENOG4108JPW Aminotransferase FOC81_RS14680 ENOG4105F8V Hydrolase, tatD family FOC81_RS14685 ENOG4105C6E dna polymerase iii FOC81_RS14690 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FOC81_RS14695 ENOG4105HHA aminodeoxychorismate lyase FOC81_RS14700 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FOC81_RS14715 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC81_RS14720 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC81_RS14725 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS14735 ENOG4108Z1B Cyclase dehydrase FOC81_RS14740 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FOC81_RS14750 ENOG4107QX8 SPFH domain, Band 7 family protein FOC81_RS14760 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC81_RS14765 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC81_RS14775 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC81_RS14800 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOC81_RS14815 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FOC81_RS14820 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOC81_RS14825 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FOC81_RS14830 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FOC81_RS14835 ENOG4105DZP Membrane-associated zinc metalloprotease FOC81_RS14840 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC81_RS14845 ENOG4105KNE Phosphatidate cytidylyltransferase FOC81_RS14850 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC81_RS14855 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FOC81_RS14860 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC81_RS14865 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FOC81_RS14870 ENOG4105CE9 30S ribosomal protein S2 FOC81_RS14875 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC81_RS14880 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FOC81_RS14890 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FOC81_RS14900 ENOG4108VKG metal-dependent hydrolase FOC81_RS14915 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FOC81_RS14920 ENOG4105E96 Colicin v production protein FOC81_RS14930 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC81_RS14945 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS14960 ENOG41063QE flagellar protein FlaG FOC81_RS14965 ENOG4107W9T flagellar hook-associated FOC81_RS14970 ENOG4105MQ3 flagellar protein FliS FOC81_RS14985 ENOG4105D00 flagellar biosynthetic protein flhB FOC81_RS14995 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FOC81_RS15000 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FOC81_RS15005 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC81_RS15010 ENOG4108CG0 Flagellar assembly protein FOC81_RS15015 ENOG4108JIR Flagellum-specific ATP synthase FOC81_RS15030 ENOG4107ZI8 flagellar basal body-associated protein flil FOC81_RS15035 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC81_RS15040 ENOG4105DD5 Flagellar motor switch protein FOC81_RS15050 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC81_RS15055 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC81_RS15060 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FOC81_RS15065 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FOC81_RS15070 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS15080 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS15085 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS15090 ENOG4105DTJ flagellar hook-associated protein FOC81_RS15095 ENOG4105E1Q flagellar hook-associated protein FOC81_RS15100 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FOC81_RS15115 ENOG4105CGA flagellar basal-body rod protein FlgG FOC81_RS15120 ENOG4108KPB Flagellar basal-body rod protein FlgF FOC81_RS15125 ENOG4105BZE flagellar hook protein, FlgE FOC81_RS15130 ENOG4105W00 Flagellar hook capping protein FOC81_RS15135 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC81_RS15140 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC81_RS15150 ENOG4105M9M anti-sigma28 factor FlgM FOC81_RS15160 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC81_RS15165 ENOG4105D7B Flagellar biosynthesis protein flha FOC81_RS15170 ENOG4105D00 flagellar biosynthetic protein flhB FOC81_RS15175 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS15180 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FOC81_RS15185 ENOG4108VYJ response regulator receiver protein FOC81_RS15190 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FOC81_RS15195 ENOG4105BZU Histidine kinase FOC81_RS15200 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS15205 ENOG4108V3W Chemotaxis protein, CheW FOC81_RS15210 ENOG4105CBS Chea signal transduction histidine kinase FOC81_RS15215 ENOG4108VYJ response regulator receiver protein FOC81_RS15220 ENOG4105ER2 Ompa motb domain protein FOC81_RS15225 ENOG4107RD7 Flagellar Motor Protein, MotA FOC81_RS15230 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region FOC81_RS15235 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) FOC81_RS15240 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC81_RS15245 ENOG4105I03 Flagellin FOC81_RS15250 ENOG4106R49 Methyltransferase FOC81_RS15255 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FOC81_RS15260 ENOG4105FAW cDP-glucose 4,6-dehydratase FOC81_RS15285 ENOG4108UW5 maltose o-acetyltransferase FOC81_RS15310 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC81_RS15315 ENOG4107QSN dihydrolipoamide acetyltransferase FOC81_RS15320 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FOC81_RS15325 ENOG4105BZU Histidine kinase FOC81_RS15330 ENOG4108ZXC Two component transcriptional regulator, luxr family FOC81_RS15335 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOC81_RS15340 ENOG4105DGW oligopeptidase A FOC81_RS15355 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC81_RS15360 ENOG4105BZS acriflavin resistance protein FOC81_RS15365 ENOG4105C1P efflux transporter, rnd family, mfp subunit FOC81_RS15370 ENOG4105JQN Transcriptional regulator FOC81_RS15375 ENOG4105FE9 pseudouridine synthase FOC81_RS15380 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) FOC81_RS15405 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC81_RS15420 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC81_RS15425 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC81_RS15430 ENOG4108IV0 ABC, transporter FOC81_RS15435 ENOG4105C0Z ABC transporter FOC81_RS15440 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC81_RS15445 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS15450 ENOG4105CP9 extracellular ligand-binding receptor FOC81_RS15455 ENOG4105FDP GntR family transcriptional regulator FOC81_RS15490 ENOG4108VWS Yaeq family FOC81_RS15495 ENOG4105N14 lysine exporter protein LysE YggA FOC81_RS15500 ENOG4108JQ6 ABC transporter FOC81_RS15505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS15510 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC81_RS15515 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS15520 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC81_RS15525 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS15530 ENOG4105HSS phospholipase C FOC81_RS15550 ENOG4108VAU general secretion pathway protein G FOC81_RS15560 ENOG4105X5Z General secretion pathway protein I FOC81_RS15565 ENOG4108WWZ General secretion pathway protein J FOC81_RS15570 ENOG4108RTD type II secretion system protein K FOC81_RS15590 ENOG4107QHF type ii secretion system protein e FOC81_RS15595 ENOG4105GVR general secretion pathway protein D FOC81_RS15600 ENOG4105D7Q type ii secretion system FOC81_RS15605 ENOG4108YZA Nitrogen regulatory protein pii FOC81_RS15615 ENOG4105CUY Mechanosensitive ion channel FOC81_RS15620 ENOG4105CH7 arginosuccinase FOC81_RS15625 ENOG4105CBN LysR family transcriptional regulator FOC81_RS15630 ENOG4105F27 Major Facilitator FOC81_RS15645 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS15650 ENOG4106NZI LysR family Transcriptional regulator FOC81_RS15655 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC81_RS15660 ENOG4107QSN dihydrolipoamide acetyltransferase FOC81_RS15665 ENOG4105CPP Dehydrogenase, E1 component FOC81_RS15670 ENOG4107R0V Pyruvate dehydrogenase FOC81_RS15675 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS15680 ENOG4108Q5F Tetr family transcriptional regulator FOC81_RS15690 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS15700 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS15705 ENOG4105CHR reductase FOC81_RS15710 ENOG4105CHR reductase FOC81_RS15725 ENOG4105F38 ABC transporter, permease FOC81_RS15730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS15735 ENOG4108HM4 ABC transporter FOC81_RS15750 ENOG4105W1Y Transcriptional regulator FOC81_RS15770 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS15780 ENOG4105CSP Major Facilitator Superfamily FOC81_RS15795 ENOG4108R6K riboflavin synthase, subunit alpha FOC81_RS15805 ENOG41073TP transcriptional regulator FOC81_RS15810 ENOG4105CHR reductase FOC81_RS15835 ENOG4108R1E Serine threonine protein phosphatase 1 FOC81_RS15840 ENOG4105EAC phosphoserine phosphatase FOC81_RS15850 ENOG4105ETE Transcriptional regulator (LacI family FOC81_RS15860 ENOG4108IV0 ABC, transporter FOC81_RS15865 ENOG4105C0Z ABC transporter FOC81_RS15875 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS15885 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC81_RS15895 ENOG4105CHR reductase FOC81_RS15900 ENOG4105ETE Transcriptional regulator (LacI family FOC81_RS15955 ENOG4105F27 Major Facilitator FOC81_RS15960 ENOG4105JQN Transcriptional regulator FOC81_RS15980 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS15985 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS15990 ENOG4105C0Z ABC transporter FOC81_RS15995 ENOG4108IV0 ABC, transporter FOC81_RS16005 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS16010 ENOG4107YCY Transcriptional regulator FOC81_RS16020 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS16030 ENOG4105DDW LysR family Transcriptional regulator FOC81_RS16090 ENOG4105W7K Transcriptional regulator FOC81_RS16105 ENOG4108IND Tetr family transcriptional regulator FOC81_RS16110 ENOG4105KPY Small multidrug resistance protein FOC81_RS16115 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FOC81_RS16130 ENOG4105BZU Histidine kinase FOC81_RS16145 ENOG4105EVD ribosomal RNA large subunit methyltransferase N FOC81_RS16150 ENOG4108PCN EamA-like transporter family FOC81_RS16155 ENOG4106PGW Short-chain dehydrogenase reductase Sdr FOC81_RS16160 ENOG4105ECQ AraC Family Transcriptional Regulator FOC81_RS16165 ENOG4105C1P efflux transporter, rnd family, mfp subunit FOC81_RS16175 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC81_RS16180 ENOG4105CR8 Transcriptional regulator FOC81_RS16185 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FOC81_RS16195 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FOC81_RS16200 ENOG4108IV0 ABC, transporter FOC81_RS16205 ENOG4105C0Z ABC transporter FOC81_RS16250 ENOG4105CHR reductase FOC81_RS16270 ENOG4108ERU trap dicarboxylate transporter subunit DctP FOC81_RS16275 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS16280 ENOG4108PVQ transcriptional regulator FOC81_RS16285 ENOG4108JJ7 ABC transporter FOC81_RS16290 ENOG4108NIW Leucine export protein LeuE FOC81_RS16295 ENOG4105EW9 transcriptional regulator AsnC family FOC81_RS16305 ENOG4105ECQ AraC Family Transcriptional Regulator FOC81_RS16325 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS16330 ENOG4105FDP GntR family transcriptional regulator FOC81_RS16345 ENOG4105CSH Transporter FOC81_RS16350 ENOG4108S8N class II Aldolase FOC81_RS16360 ENOG4108Z4K mutator MutT protein FOC81_RS16365 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS16385 ENOG4105CY2 Citrate transporter FOC81_RS16390 ENOG4105CBN LysR family transcriptional regulator FOC81_RS16395 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC81_RS16400 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS16405 ENOG4105BZU Histidine kinase FOC81_RS16415 ENOG4105C01 Dihydroxy-acid dehydratase FOC81_RS16430 ENOG4105CDA abc transporter atp-binding protein FOC81_RS16435 ENOG4105DRP amino acid AbC transporter FOC81_RS16440 ENOG4105EAD ABC transporter FOC81_RS16445 ENOG4107RP9 extracellular solute-binding protein, family 3 FOC81_RS16450 ENOG4105C9B Cysteine desulfurase FOC81_RS16465 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS16475 ENOG4105D05 Receptor FOC81_RS16490 ENOG4105CTK cobaltochelatase, cobn subunit FOC81_RS16520 ENOG4105E93 esterase FOC81_RS16535 ENOG4107VGR Catalase FOC81_RS16550 ENOG4105E33 succinate dehydrogenase FOC81_RS16555 ENOG4107RSM transcriptional regulator FOC81_RS16560 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC81_RS16595 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FOC81_RS16600 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FOC81_RS16605 ENOG41060IM Heme exporter protein FOC81_RS16620 ENOG4105DA4 cytochrome c-type biogenesis protein FOC81_RS16625 ENOG4107QX9 Thiol disulfide interChange protein FOC81_RS16630 ENOG4105KWW Biogenesis protein FOC81_RS16640 ENOG4105DB1 molybdopterin oxidoreductase FOC81_RS16645 ENOG4106WHD Tetrathionate reductase FOC81_RS16650 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FOC81_RS16660 ENOG4105EUB pirin domain protein FOC81_RS16675 ENOG4108K3Z AraC family transcriptional regulator FOC81_RS16680 ENOG4105DQ4 alcohol dehydrogenase FOC81_RS16685 ENOG4107RTG Major Facilitator superfamily FOC81_RS16690 ENOG4105ENX hydrolase FOC81_RS16695 ENOG4105EQ2 LysR family Transcriptional regulator FOC81_RS16730 ENOG4108R85 Short chain dehydrogenase FOC81_RS16740 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC81_RS16770 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS16775 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC81_RS16780 ENOG4108IUZ ABC transporter FOC81_RS16785 ENOG4108IUZ ABC transporter FOC81_RS16805 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) FOC81_RS16810 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC81_RS16820 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC81_RS16825 ENOG4108IPT Naphthoate synthase FOC81_RS16865 ENOG4105N14 lysine exporter protein LysE YggA FOC81_RS16875 ENOG4105DC8 reductase FOC81_RS16885 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FOC81_RS16890 ENOG4105MPD Cytochrome FOC81_RS16900 ENOG4108W3Y Transcriptional regulator, Crp Fnr family FOC81_RS16910 ENOG4105DSQ Nitric oxide reductase FOC81_RS16930 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS16935 ENOG4105CSU acyl-Coa dehydrogenase FOC81_RS16960 ENOG4105EXG Transcriptional regulator FOC81_RS16980 ENOG41062BK proline dehydrogenase FOC81_RS16985 ENOG4105SX7 Transporter FOC81_RS16990 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC81_RS16995 ENOG4105KPV Transcriptional regulator FOC81_RS17075 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC81_RS17085 ENOG4105C2D reductase FOC81_RS17090 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC81_RS17100 ENOG4105KTH gatB Yqey FOC81_RS17105 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC81_RS17140 ENOG4105BZU Histidine kinase FOC81_RS17145 ENOG4108TUY outer membrane protein PgaA FOC81_RS17150 ENOG4107BJW polysaccharide deacetylase FOC81_RS17155 ENOG4105CND Glycosyl transferase, family 2 FOC81_RS17165 ENOG4105EU0 Major facilitator Superfamily FOC81_RS17170 ENOG4105ID8 Transcriptional regulator, ARAC family FOC81_RS17175 ENOG4108JQC penicillin-binding protein 1A FOC81_RS17180 ENOG4108R1E Serine threonine protein phosphatase 1 FOC81_RS17195 ENOG4105CV8 reductase FOC81_RS17200 ENOG4108JJ7 ABC transporter FOC81_RS17210 ENOG4105DHU Bile acid FOC81_RS17215 ENOG4105C5Q Transcriptional regulator FOC81_RS17235 ENOG4108MGI Transcriptional regulator FOC81_RS17270 ENOG4108YXU transcriptional regulator AsnC family FOC81_RS17305 ENOG4108R6G acetyltransferase FOC81_RS17310 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC81_RS17320 ENOG4105C5I Dehydrogenase FOC81_RS17345 ENOG4106DX9 Aromatic-ring-hydroxylating dioxygenase beta subunit FOC81_RS17350 ENOG4105FUY alpha subunit FOC81_RS17380 ENOG4105BZU Histidine kinase FOC81_RS17385 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC81_RS17400 ENOG4105IH7 synthase FOC81_RS17405 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC81_RS17425 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FOC81_RS17430 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC81_RS17435 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FOC81_RS17440 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FOC81_RS17445 ENOG4105VJV 50s ribosomal protein L35 FOC81_RS17450 ENOG4105C0P Mg chelatase subunit ChlI FOC81_RS17455 ENOG4105W0Z cytoplasmic protein FOC81_RS17475 ENOG4105WAB arsR family transcriptional regulator FOC81_RS17480 ENOG4108YZA Nitrogen regulatory protein pii FOC81_RS17485 ENOG4105BZU Histidine kinase FOC81_RS17490 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC81_RS17495 ENOG41080Z8 PHOSPHOCARRIER protein FOC81_RS17510 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC81_RS17515 ENOG4105C22 threonyL-tRNA synthetase FOC81_RS17525 ENOG41068CG regulatoR FOC81_RS17530 ENOG4105D4P Coproporphyrinogen iii oxidase FOC81_RS17550 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC81_RS17555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS17560 ENOG4108JQ6 ABC transporter FOC81_RS17565 ENOG4105K8K Cupin 2, conserved barrel FOC81_RS17630 ENOG4105VEQ Cold shock protein FOC81_RS17640 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FOC81_RS17645 ENOG4105CH5 extracellular solute-binding protein, family 7 FOC81_RS17650 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC81_RS17660 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC81_RS17680 ENOG4105DFG type I secretion outer membrane protein FOC81_RS17720 ENOG4105ERG peptidase m48, ste24p FOC81_RS17725 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC81_RS17730 ENOG4105BZU Histidine kinase FOC81_RS17740 ENOG4105BZU Histidine kinase FOC81_RS17750 ENOG4105CNG UPF0061 protein FOC81_RS17760 ENOG4107S2Z UPF0761 membrane protein FOC81_RS17770 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC81_RS17840 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FOC81_RS17855 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC81_RS17860 ENOG4105D8K carboxyl transferase FOC81_RS17865 ENOG4107QNJ CoA-transferase subunit B FOC81_RS17895 ENOG4105N0V mono-oxygenase ydhR FOC81_RS18015 ENOG4105E4C Lytic transglycosylase catalytic FOC81_RS18030 ENOG4105TKZ Tail Sheath FOC81_RS18205 ENOG4108KU3 Integrase FOC81_RS18215 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC81_RS18225 ENOG4105VCC 30S ribosomal protein S21 FOC81_RS18230 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) FOC81_RS18235 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOC81_RS18240 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FOC81_RS18245 ENOG4105EPW hflc protein FOC81_RS18250 ENOG4107QJR hflk protein FOC81_RS18255 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC81_RS18260 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC81_RS18265 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC81_RS18270 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FOC81_RS18275 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FOC81_RS18280 ENOG4105N21 Membrane FOC81_RS18285 ENOG4105CUT histidyl-tRNA synthetase FOC81_RS18300 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FOC81_RS18305 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FOC81_RS18310 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC81_RS18315 ENOG4105CJP fad dependent oxidoreductase FOC81_RS18320 ENOG4105CDA abc transporter atp-binding protein FOC81_RS18325 ENOG4105E5Q amino acid AbC transporter FOC81_RS18335 ENOG4105WBV Transcriptional regulator FOC81_RS18340 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FOC81_RS18345 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FOC81_RS18350 ENOG4105K5M 30s ribosomal protein S16 FOC81_RS18360 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FOC81_RS18365 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC81_RS18415 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC81_RS18425 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FOC81_RS18430 ENOG4105QVC MOSC domain-containing protein FOC81_RS18435 ENOG4105EV8 ectoine hydroxylase FOC81_RS18440 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FOC81_RS18465 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC81_RS18470 ENOG4105H1G trap transporter solute receptor taxi family FOC81_RS18485 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC81_RS18495 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC81_RS18500 ENOG4105K63 Thioredoxin FOC81_RS18505 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC81_RS18515 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FOC81_RS18520 ENOG4105WPN DNA integration recombination invertion protein FOC81_RS18565 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC81_RS18580 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FOC81_RS18590 ENOG4105CW7 secretion protein, HlyD family FOC81_RS18595 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC81_RS18605 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FOC81_RS18610 ENOG4105D7A ATP-binding protein FOC81_RS18615 ENOG4105CDY transcriptional regulatory protein FOC81_RS18620 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC81_RS18630 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FOC81_RS18635 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FOC81_RS18640 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FOC81_RS18645 ENOG4108Z03 MAF-like protein FOC81_RS18650 ENOG4105CK2 sodium dicarboxylate symporter FOC81_RS18690 ENOG4105C03 ribonuclease FOC81_RS18695 ENOG4106JH6 (LipO)protein FOC81_RS18705 ENOG4105CKD glutathione-regulated potassium-efflux system protein FOC81_RS18710 ENOG4105BZ1 (ABC) transporter FOC81_RS18725 ENOG4105KRS Proteinase inhibitor FOC81_RS18730 ENOG4105CUT histidyl-tRNA synthetase FOC81_RS18740 ENOG4107BJW polysaccharide deacetylase FOC81_RS18750 ENOG4106WTF Glycosyl transferase, family 2 FOC81_RS18755 ENOG4107BJW polysaccharide deacetylase FOC81_RS18760 ENOG4105CPK Glycosyl transferase (Group 1 FOC81_RS18765 ENOG4105C0B DNA polymerase III (alpha subunit) FOC81_RS18775 ENOG4105CQ7 ATP-dependent helicase FOC81_RS18780 ENOG4108EKC n-acetylglutamate synthase FOC81_RS18785 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) FOC81_RS18790 ENOG4105HSS phospholipase C FOC81_RS18795 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC81_RS18800 ENOG4105E66 phosphoriboisomerase A FOC81_RS18805 ENOG4105CSU acyl-Coa dehydrogenase FOC81_RS18835 ENOG4105D38 putrescine abc transporter FOC81_RS18840 ENOG4105F38 ABC transporter, permease FOC81_RS18845 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS18855 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) FOC81_RS18865 ENOG4105CV6 ABC transporter, permease FOC81_RS18870 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOC81_RS18880 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS18885 ENOG4108JQ7 (ABC) transporter FOC81_RS18890 ENOG4105C3U ABC transporter FOC81_RS18905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS18910 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC81_RS18915 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS18935 ENOG4105C8Y Acetylornithine aminotransferase FOC81_RS18940 ENOG4105DBV ornithine carbamoyltransferase FOC81_RS18975 ENOG4105GAK amidohydrolase 2 FOC81_RS18985 ENOG4105GR3 Histidine kinase FOC81_RS18995 ENOG4105BZS acriflavin resistance protein FOC81_RS19000 ENOG4105ENT Efflux transporter rnd family, mfp subunit FOC81_RS19005 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC81_RS19010 ENOG4105CDH Citrulline--aspartate ligase FOC81_RS19015 ENOG4105DFH Transport of potassium into the cell (By similarity) FOC81_RS19020 ENOG4105DHQ Histidine kinase FOC81_RS19025 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC81_RS19050 ENOG4105K70 DNA-binding protein FOC81_RS19055 ENOG4107E2E PKHD-type hydroxylase FOC81_RS19060 ENOG4105C28 cystathionine FOC81_RS19065 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC81_RS19070 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC81_RS19090 ENOG4108HPG -acetyltransferase FOC81_RS19110 ENOG41066VF YeeE YedE family protein FOC81_RS19115 ENOG4105CBC glutamate synthase FOC81_RS19120 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC81_RS19130 ENOG41067HS methyltransferase FOC81_RS19175 ENOG4105BZU Histidine kinase FOC81_RS19185 ENOG4108REF Sporulation integral membrane protein ytvi FOC81_RS19215 ENOG4105T86 cytochrome C FOC81_RS19220 ENOG4107QTF adenylosuccinate lyase FOC81_RS19225 ENOG4108U78 Glutathione S-transferase FOC81_RS19240 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC81_RS19245 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS19260 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FOC81_RS19265 ENOG4105W8H transhydrogenase (subunit alpha FOC81_RS19270 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FOC81_RS19275 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC81_RS19280 ENOG4105EU8 FAD linked oxidase domain protein FOC81_RS19285 ENOG4105CQB FAD linked oxidase domain protein FOC81_RS19290 ENOG4105CQB FAD linked oxidase domain protein FOC81_RS19295 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FOC81_RS19300 ENOG4105D1U peptidase U62 modulator of DNA gyrase FOC81_RS19305 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS FOC81_RS19315 ENOG4105CD8 aminopeptidase N FOC81_RS19320 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 FOC81_RS19335 ENOG4105D6E homoserine dehydrogenase FOC81_RS19340 ENOG4105CHM Aminotransferase FOC81_RS19350 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC81_RS19355 ENOG4108IAB Phoh family FOC81_RS19370 ENOG4105F0N pyrophosphate phospho-hydrolase FOC81_RS19390 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FOC81_RS19395 ENOG4108ZCF integral membrane protein FOC81_RS19400 ENOG4108ZCF integral membrane protein FOC81_RS19405 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC81_RS19410 ENOG4105CMV Succinyl-CoA synthetase subunit beta FOC81_RS19425 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS19435 ENOG4105DZ2 Transcriptional regulator FOC81_RS19440 ENOG4108004 Modulates RecA activity (By similarity) FOC81_RS19445 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FOC81_RS19455 ENOG4105DHQ Histidine kinase FOC81_RS19460 ENOG4105CSH Transporter FOC81_RS19480 ENOG4105CXT aspartate transcarbamylase FOC81_RS19530 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC81_RS19555 ENOG4105EW9 transcriptional regulator AsnC family FOC81_RS19565 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FOC81_RS19570 ENOG4105DHU Bile acid FOC81_RS19575 ENOG4105CDU Replicative dna helicase FOC81_RS19585 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FOC81_RS19590 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FOC81_RS19600 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FOC81_RS19605 ENOG4105NX3 Membrane FOC81_RS19610 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) FOC81_RS19620 ENOG4105CTB Polyprenyl synthetase FOC81_RS19625 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FOC81_RS19660 ENOG4108KAZ Involved in phosphonate degradation (By similarity) FOC81_RS19670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS19675 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS19690 ENOG4105CC0 LysR family Transcriptional regulator FOC81_RS19695 ENOG4105KHC sulfurtransferase FOC81_RS19705 ENOG4105D0M Protease HtpX homolog FOC81_RS19710 ENOG4105EJQ L-serine dehydratase FOC81_RS19715 ENOG4105EAM Na Pi-cotransporter FOC81_RS19725 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FOC81_RS19730 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) FOC81_RS19735 ENOG4105C2M dna polymerase I FOC81_RS19740 ENOG4108URH decarboxylase FOC81_RS19750 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B FOC81_RS19760 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS19765 ENOG4105F04 LysR family Transcriptional regulator FOC81_RS19775 ENOG4105CI3 gtp-binding protein typa FOC81_RS19780 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC81_RS19785 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FOC81_RS19790 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FOC81_RS19795 ENOG4105CHV Transcription elongation factor NusA FOC81_RS19800 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FOC81_RS19805 ENOG4105FE9 pseudouridine synthase FOC81_RS19810 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FOC81_RS19820 ENOG4105EJC lysr family transcriptional regulator FOC81_RS19825 ENOG4105CKI cobalamin synthesis protein FOC81_RS19855 ENOG4108QBF Transcriptional regulator FOC81_RS19860 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FOC81_RS19865 ENOG4105XJC Two component transcriptional regulator (Winged helix family FOC81_RS19870 ENOG4105DHQ Histidine kinase FOC81_RS19875 ENOG4105C0H protease FOC81_RS19880 ENOG4108RXX maleylacetoacetate isomerase FOC81_RS19885 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FOC81_RS19890 ENOG4108YZY peptidylprolyl cis-trans isomerase FOC81_RS19895 ENOG4105W5Q DNA repair protein (RadC FOC81_RS19900 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC81_RS19905 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) FOC81_RS19920 ENOG4107QI1 Mate efflux family protein FOC81_RS19930 ENOG4108ZJI phenylacetic acid degradation protein FOC81_RS19935 ENOG4108UKI Enoyl-CoA hydratase FOC81_RS19945 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC81_RS19950 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FOC81_RS19955 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FOC81_RS19960 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FOC81_RS19965 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FOC81_RS19970 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FOC81_RS20000 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FOC81_RS20005 ENOG4105D0M Protease HtpX homolog FOC81_RS20010 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC81_RS20020 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FOC81_RS20040 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FOC81_RS20055 ENOG4108IJ6 ABC transporter FOC81_RS20060 ENOG4105ECW sulfate abc transporter FOC81_RS20065 ENOG4108I5D sulfate abc transporter FOC81_RS20070 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FOC81_RS20075 ENOG4105D3R alkyl hydroperoxide reductase FOC81_RS20080 ENOG4105CSU acyl-Coa dehydrogenase FOC81_RS20090 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC81_RS20095 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS20120 ENOG4105C10 Electron transfer flavoprotein FOC81_RS20125 ENOG4105BZJ Electron transfer flavoprotein FOC81_RS20135 ENOG4105CVE Lytic murein transglycosylase FOC81_RS20155 ENOG4105C6T cysteine synthase FOC81_RS20165 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FOC81_RS20170 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FOC81_RS20175 ENOG4105CFV Tetratricopeptide repeat protein FOC81_RS20190 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FOC81_RS20195 ENOG4105CAT Cytidine monophosphate kinase FOC81_RS20200 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FOC81_RS20205 ENOG4105EVN Prephenate dehydrogenase FOC81_RS20220 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOC81_RS20225 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC81_RS20230 ENOG4105UYK outer membrane protein a FOC81_RS20235 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC81_RS20240 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC81_RS20245 ENOG4105F27 Major Facilitator FOC81_RS20265 ENOG4105EUZ Beta-lactamase domain protein FOC81_RS20280 ENOG4105CVE Lytic murein transglycosylase FOC81_RS20285 ENOG4108RPX mosc domain containing protein FOC81_RS20290 ENOG4105ED9 Protein of unknown function (DUF455) FOC81_RS20305 ENOG4105BZ1 (ABC) transporter FOC81_RS20320 ENOG4105VDW Csbd family FOC81_RS20335 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC81_RS20345 ENOG4105EKT )-iron permease FOC81_RS20360 ENOG4108NVM synthesis repressor PhaR FOC81_RS20365 ENOG4105CHR reductase FOC81_RS20370 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FOC81_RS20375 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC81_RS20380 ENOG4105C34 Pseudouridine synthase FOC81_RS20400 ENOG4105DVT helicase FOC81_RS20405 ENOG4105BZM domain protein FOC81_RS20435 ENOG4105E0K tonB-dependent siderophore receptor FOC81_RS20440 ENOG4108S3W Anti-feci sigma factor, fecr FOC81_RS20445 ENOG4108SF5 RNA Polymerase FOC81_RS20450 ENOG4105D6Z AFG1 family ATPase FOC81_RS20455 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC81_RS20460 ENOG4105C7S Dehydrogenase FOC81_RS20465 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FOC81_RS20470 ENOG4105EW9 transcriptional regulator AsnC family FOC81_RS20490 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FOC81_RS20495 ENOG4105EPD Oligopeptide transporter, Opt family FOC81_RS20500 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FOC81_RS20505 ENOG4105C6K Malic enzyme FOC81_RS20520 ENOG4108IV0 ABC, transporter FOC81_RS20555 ENOG4105BZN citrate synthase FOC81_RS20560 ENOG41060IS Flavinator of succinate dehydrogenase FOC81_RS20565 ENOG4105E33 succinate dehydrogenase FOC81_RS20575 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FOC81_RS20580 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FOC81_RS20585 ENOG4105FDP GntR family transcriptional regulator FOC81_RS20590 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC81_RS20595 ENOG4105CR4 methylisocitrate lyase FOC81_RS20600 ENOG4105BZN citrate synthase FOC81_RS20605 ENOG4105DXD 2-methylcitrate dehydratase FOC81_RS20610 ENOG4108YXA Membrane FOC81_RS20615 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC81_RS20640 ENOG4108Z0R Transferase FOC81_RS20645 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FOC81_RS20660 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FOC81_RS20670 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOC81_RS20695 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS20705 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS20710 ENOG4108JQ6 ABC transporter FOC81_RS20715 ENOG4105D44 asparaginase FOC81_RS20725 ENOG4107YB6 acetyltransferase, (GNAT) family FOC81_RS20745 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FOC81_RS20765 ENOG4105G3Z GntR family transcriptional regulator FOC81_RS20770 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC81_RS20775 ENOG4105C5W Aldolase FOC81_RS20780 ENOG4108Q5Y Membrane FOC81_RS20795 ENOG4108ZJF Glcg protein FOC81_RS20800 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC81_RS20805 ENOG4105K4H Nlp p60 protein FOC81_RS20815 ENOG4107R11 Transcriptional regulator FOC81_RS20820 ENOG4105C26 Dehydrogenase FOC81_RS20830 ENOG4108MP6 LysR family Transcriptional regulator FOC81_RS20840 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FOC81_RS20890 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FOC81_RS20895 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC81_RS20900 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FOC81_RS20905 ENOG4105C3F Signal peptidase i FOC81_RS20915 ENOG4105C0H protease FOC81_RS20930 ENOG4105EMN RNA polymerase sigma factor FOC81_RS20935 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC81_RS20940 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FOC81_RS20945 ENOG4105CHR reductase FOC81_RS20950 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC81_RS20955 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC81_RS20960 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FOC81_RS20965 ENOG4105VGS 50s ribosomal protein l32 FOC81_RS20970 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FOC81_RS20975 ENOG4108UHJ MAF-like protein FOC81_RS20985 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FOC81_RS20990 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) FOC81_RS20995 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FOC81_RS21000 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC81_RS21005 ENOG4105EI2 Pseudouridine synthase FOC81_RS21010 ENOG4105C03 ribonuclease FOC81_RS21025 ENOG4105CTX dehydratase FOC81_RS21035 ENOG41061N2 exported protein FOC81_RS21040 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FOC81_RS21045 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FOC81_RS21060 ENOG4105CSH Transporter FOC81_RS21065 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC81_RS21070 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) FOC81_RS21075 ENOG4107ZS6 Flavodoxin FOC81_RS21080 ENOG4105M4H endoribonuclease L-psp FOC81_RS21085 ENOG4107RH7 Nicotinate phosphoribosyltransferase FOC81_RS21090 ENOG4108Z4U Ferredoxin FOC81_RS21095 ENOG4105DP0 ferredoxin-NADP reductase FOC81_RS21105 ENOG4108R3D Electron transport complex FOC81_RS21110 ENOG4105CSM endonuclease III FOC81_RS21115 ENOG4105C0Z ABC transporter FOC81_RS21120 ENOG4108IV0 ABC, transporter FOC81_RS21130 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS21150 ENOG4105HSS phospholipase C FOC81_RS21160 ENOG4108IV0 ABC, transporter FOC81_RS21165 ENOG4105C0Z ABC transporter FOC81_RS21180 ENOG4107ZYJ bioY protein FOC81_RS21185 ENOG4107QCX Transporter FOC81_RS21190 ENOG4108JJB ABC transporter FOC81_RS21195 ENOG4105E0X reductase FOC81_RS21200 ENOG4107835 probably involved in intracellular septation (By similarity) FOC81_RS21205 ENOG4105M85 Bola protein FOC81_RS21210 ENOG4107TF3 peptidylprolyl cis-trans isomerase FOC81_RS21215 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOC81_RS21225 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC81_RS21230 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FOC81_RS21235 ENOG4108UN4 phage SPO1 DNA polymerase-related protein FOC81_RS21240 ENOG41072GX Peptidase M22 Glycoprotease FOC81_RS21250 ENOG4105E0F Histidine kinase FOC81_RS21255 ENOG4105D3R alkyl hydroperoxide reductase FOC81_RS21260 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FOC81_RS21265 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FOC81_RS21270 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOC81_RS21275 ENOG4108JA2 transcriptioN-repair coupling factor FOC81_RS21280 ENOG4105EAC phosphoserine phosphatase FOC81_RS21285 ENOG4108ESX Receptor FOC81_RS21295 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC81_RS21300 ENOG4105C8S subunit m FOC81_RS21310 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC81_RS21315 ENOG4105DF2 NADH dehydrogenase subunit j FOC81_RS21320 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC81_RS21325 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) FOC81_RS21330 ENOG4108IEH NADH dehydrogenase subunit g FOC81_RS21350 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC81_RS21355 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC81_RS21360 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC81_RS21365 ENOG4108Z9W Outer membrane porin FOC81_RS21390 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FOC81_RS21395 ENOG4105CBD Diacylglycerol kinase FOC81_RS21415 ENOG4108IG5 Transcriptional regulator FOC81_RS21420 ENOG4105C1P efflux transporter, rnd family, mfp subunit FOC81_RS21425 ENOG4105BZS acriflavin resistance protein FOC81_RS21430 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC81_RS21445 ENOG4105BZS acriflavin resistance protein FOC81_RS21450 ENOG4105ENT Efflux transporter rnd family, mfp subunit FOC81_RS21455 ENOG4105C94 Transporter FOC81_RS21460 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC81_RS21475 ENOG4105BZS acriflavin resistance protein FOC81_RS21480 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC81_RS21495 ENOG4106R87 Extracellular solute-binding protein, family 5 FOC81_RS21505 ENOG4108JQ6 ABC transporter FOC81_RS21525 ENOG4105CKW Inner membrane protein yedI FOC81_RS21530 ENOG4105XDF Protein of unknown function (DUF1272) FOC81_RS21540 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC81_RS21555 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FOC81_RS21560 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS21565 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS21570 ENOG4106P55 Transcriptional regulator FOC81_RS21585 ENOG4108JQ6 ABC transporter FOC81_RS21605 ENOG4105ENH Sulfatase FOC81_RS21615 ENOG4105CHR reductase FOC81_RS21620 ENOG4105D4T Citrate transporter FOC81_RS21630 ENOG4105ECM Sensor protein basS pmrB FOC81_RS21660 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS21680 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS21690 ENOG4105C0Z ABC transporter FOC81_RS21695 ENOG4108IV0 ABC, transporter FOC81_RS21745 ENOG4108NFJ ABC transporter FOC81_RS21820 ENOG4105F38 ABC transporter, permease FOC81_RS21825 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS21830 ENOG4107RUE extracellular solute-binding protein family 1 FOC81_RS21835 ENOG410810E transcriptional regulator, lysR family FOC81_RS21845 ENOG4105HEI LysR family (Transcriptional regulator FOC81_RS21860 ENOG4107SFI Major Facilitator superfamily FOC81_RS21865 ENOG4105CHJ isochorismatase hydrolase FOC81_RS21875 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS21890 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS21895 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS21935 ENOG4105CHR reductase FOC81_RS21945 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC81_RS21950 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOC81_RS21955 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS21960 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter FOC81_RS21965 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) FOC81_RS22005 ENOG4108Z7R Chaperone CsaA FOC81_RS22025 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS22045 ENOG4105RHY Pfam:UPF0157 FOC81_RS22055 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS22065 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS22075 ENOG4105CHR reductase FOC81_RS22090 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS22130 ENOG4105CHR reductase FOC81_RS22135 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC81_RS22140 ENOG4105DDW LysR family Transcriptional regulator FOC81_RS22150 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC81_RS22155 ENOG4105KME endoribonuclease L-psp FOC81_RS22200 ENOG4108PZW LysR family Transcriptional regulator FOC81_RS22240 ENOG4105BZU Histidine kinase FOC81_RS22260 ENOG4105E32 cytoplasmic protein FOC81_RS22265 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS22275 ENOG4105HSS phospholipase C FOC81_RS22290 ENOG4105D5T phosphonate abc transporter FOC81_RS22305 ENOG4106KNT transcriptional regulator FOC81_RS22310 ENOG4105NTZ Preprotein translocase subunit SecG FOC81_RS22315 ENOG4105CP7 Triose-phosphate isomerase FOC81_RS22320 ENOG4108JA1 polyketide synthase FOC81_RS22330 ENOG4105CRE cytochrome C FOC81_RS22335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC81_RS22345 ENOG4105N7H Cytochrome FOC81_RS22350 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC81_RS22360 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC81_RS22365 ENOG4108UMR transcriptional regulator AsnC family FOC81_RS22370 ENOG4108ZGY Transcriptional regulator (AsnC family) FOC81_RS22375 ENOG4108UMR transcriptional regulator AsnC family FOC81_RS22380 ENOG4106P6N cytochrome d1 heme region FOC81_RS22385 ENOG4105Y7H Cytochrome FOC81_RS22390 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC81_RS22405 ENOG4105ES4 Nitrilase FOC81_RS22420 ENOG4105C7B Threonine dehydratase FOC81_RS22430 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FOC81_RS22435 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FOC81_RS22445 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC81_RS22450 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC81_RS22455 ENOG4108ZP8 Acetolactate synthase small subunit FOC81_RS22460 ENOG4105C7K acetolactate synthase FOC81_RS22470 ENOG4105D1Q UPF0246 protein FOC81_RS22475 ENOG4105DTD Dehydrogenase FOC81_RS22480 ENOG4105CKD glutathione-regulated potassium-efflux system protein FOC81_RS22490 ENOG4107QKZ Ompa motb domain protein FOC81_RS22495 ENOG4107RT4 flavin reductase domain protein FOC81_RS22500 ENOG4105ES4 Nitrilase FOC81_RS22505 ENOG4105CSH Transporter FOC81_RS22515 ENOG41066DG (EAL) domain protein FOC81_RS22525 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC81_RS22530 ENOG4105DIA mandelate racemase muconate lactonizing FOC81_RS22570 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FOC81_RS22575 ENOG4105D1H recombination factor protein RarA FOC81_RS22590 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS22620 ENOG4105C2X Arabinose 5-phosphate isomerase FOC81_RS22630 ENOG4105KME endoribonuclease L-psp FOC81_RS22635 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FOC81_RS22640 ENOG4105CNU cell division protein FtsK FOC81_RS22645 ENOG4105C3M thioredoxin reductase FOC81_RS22650 ENOG4105C98 muts2 protein FOC81_RS22660 ENOG4107QN1 sodium solute FOC81_RS22675 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FOC81_RS22680 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FOC81_RS22685 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FOC81_RS22690 ENOG4105C08 Histidine kinase FOC81_RS22695 ENOG4105EEX Two component transcriptional regulator (Winged helix family FOC81_RS22710 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC81_RS22715 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS22745 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC81_RS22780 ENOG4105EQR Transposase IS116 IS110 IS902 FOC81_RS22785 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOC81_RS22790 ENOG4105CFG Acts as a chaperone (By similarity) FOC81_RS22800 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FOC81_RS22810 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC81_RS22815 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FOC81_RS22825 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC81_RS22830 ENOG41090R7 Ferric uptake FOC81_RS22835 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FOC81_RS22870 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS22885 ENOG4105C26 Dehydrogenase FOC81_RS22895 ENOG4105CPQ Dehydrogenase FOC81_RS22900 ENOG4105DTI Phosphonopyruvate decarboxylase FOC81_RS22925 ENOG4106KR7 LysR family Transcriptional regulator FOC81_RS22935 ENOG4105CH2 amidohydrolase FOC81_RS22940 ENOG4105CSH Transporter FOC81_RS22985 ENOG4105E09 nadh pyrophosphatase FOC81_RS22990 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FOC81_RS22995 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate FOC81_RS23000 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) FOC81_RS23015 ENOG41069M3 Transcriptional regulator FOC81_RS23020 ENOG4105CEV competence damage-inducible protein FOC81_RS23035 ENOG4105C1J atp-dependent rna helicase FOC81_RS23050 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC81_RS23065 ENOG4105DNZ Alpha Beta Hydrolase FOC81_RS23070 ENOG4105ERG peptidase m48, ste24p FOC81_RS23085 ENOG4108Z9W Outer membrane porin FOC81_RS23090 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOC81_RS23105 ENOG4107RAQ aminopeptidase FOC81_RS23115 ENOG4105D0A hydroxylase FOC81_RS23120 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC81_RS23135 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FOC81_RS23140 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FOC81_RS23145 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC81_RS23155 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FOC81_RS23175 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC81_RS23180 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC81_RS23190 ENOG4105CX6 glutaminyL-tRNA synthetase FOC81_RS23195 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FOC81_RS23200 ENOG4107QMS site-determining protein FOC81_RS23205 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) FOC81_RS23220 ENOG4105C5H ABC transporter FOC81_RS23240 ENOG4108JQ7 (ABC) transporter FOC81_RS23245 ENOG4105C3U ABC transporter FOC81_RS23250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS23255 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC81_RS23260 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS23285 ENOG4105FUY alpha subunit FOC81_RS23310 ENOG4106IPI cyclase, family FOC81_RS23315 ENOG4105CHR reductase FOC81_RS23330 ENOG4105C0Z ABC transporter FOC81_RS23335 ENOG4108IV0 ABC, transporter FOC81_RS23340 ENOG4105K64 Glycosyl transferase, family 2 FOC81_RS23365 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC81_RS23400 ENOG4105CUZ uba thif-type nad fad binding protein FOC81_RS23410 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC81_RS23415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC81_RS23420 ENOG4105DJY efflux transporter, rnd family, mfp subunit FOC81_RS23435 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) FOC81_RS23445 ENOG4105D5U fad dependent oxidoreductase FOC81_RS23455 ENOG4105CHH sulfate transporter FOC81_RS23460 ENOG4107RSM transcriptional regulator FOC81_RS23465 ENOG4105CSU acyl-Coa dehydrogenase FOC81_RS23475 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS23485 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS23505 ENOG4105K8N protein family UPF0079, ATPase FOC81_RS23510 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC81_RS23515 ENOG4105DQR SNARE associated Golgi FOC81_RS23520 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FOC81_RS23525 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FOC81_RS23530 ENOG4105CXB phosphoribosylaminoimidazole synthetase FOC81_RS23535 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) FOC81_RS23545 ENOG4105DJ0 Poly(A) Polymerase FOC81_RS23550 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC81_RS23555 ENOG4108MGF sugar kinase FOC81_RS23560 ENOG4105CI0 Citrate lyase FOC81_RS23570 ENOG4108M9J MaoC like domain protein FOC81_RS23580 ENOG4108UKI Enoyl-CoA hydratase FOC81_RS23585 ENOG4108KC2 acyl-Coa dehydrogenase FOC81_RS23590 ENOG4105X7H acyl-CoA dehydrogenase FOC81_RS23600 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS23605 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS23630 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FOC81_RS23640 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS23675 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FOC81_RS23680 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FOC81_RS23685 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC81_RS23690 ENOG4105E9Q Acyl-transferase FOC81_RS23710 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC81_RS23715 ENOG4107QPN acyl-Coa dehydrogenase FOC81_RS23725 ENOG4105CA9 Pyruvate kinase FOC81_RS23730 ENOG4105BZW Glycerate kinase FOC81_RS23735 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FOC81_RS23740 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FOC81_RS23750 ENOG4105EHM Aminoglycoside phosphotransferase FOC81_RS23755 ENOG4108S0S Nucleotidyl transferase FOC81_RS23780 ENOG4105KZX Pterin carbinolamine dehydratase FOC81_RS23810 ENOG41067B5 Histone deacetylase superfamily protein FOC81_RS23825 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC81_RS23835 ENOG4105C8Y Acetylornithine aminotransferase FOC81_RS23840 ENOG4105CUV Homoserine Kinase FOC81_RS23845 ENOG4108WYP Transcriptional regulator FOC81_RS23860 ENOG4105CVR type I restriction-modification system FOC81_RS23865 ENOG4105EKX Restriction modification system DNA (Specificity FOC81_RS23870 ENOG4105DZR Type I site-specific deoxyribonuclease FOC81_RS23885 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOC81_RS23910 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FOC81_RS23925 ENOG41066T0 asmA family FOC81_RS23930 ENOG4105E0M Sulfatase FOC81_RS23935 ENOG4108R3E Dna-3-methyladenine glycosylase i FOC81_RS23950 ENOG41090R7 Ferric uptake FOC81_RS23965 ENOG4105CHJ isochorismatase hydrolase FOC81_RS23970 ENOG4105CC0 LysR family Transcriptional regulator FOC81_RS23980 ENOG4105E9Z Nad-dependent epimerase dehydratase FOC81_RS23985 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FOC81_RS23990 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS24000 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC81_RS24015 ENOG4105D01 (LipO)protein FOC81_RS24020 ENOG4108UMI ABC transporter, permease FOC81_RS24025 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS24030 ENOG4105CJQ hydrolase, family 31 FOC81_RS24035 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FOC81_RS24040 ENOG4105ECY inositol monophosphatase FOC81_RS24045 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS24050 ENOG4105CH2 amidohydrolase FOC81_RS24055 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS24060 ENOG4105HMI Membrane FOC81_RS24065 ENOG4105NAU thioesterase Superfamily protein FOC81_RS24070 ENOG4105CJW magnesium transporter FOC81_RS24085 ENOG4108XM1 transcriptional regulator AsnC family FOC81_RS24095 ENOG4105C7K acetolactate synthase FOC81_RS24120 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FOC81_RS24125 ENOG4105DR5 peptidase FOC81_RS24135 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FOC81_RS24140 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC81_RS24145 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC81_RS24150 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FOC81_RS24155 ENOG4105CPF Cell wall formation (By similarity) FOC81_RS24160 ENOG4105DFU Cell wall formation (By similarity) FOC81_RS24175 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FOC81_RS24180 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FOC81_RS24185 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC81_RS24190 ENOG4105CJN penicillin-binding protein FOC81_RS24195 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FOC81_RS24200 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FOC81_RS24205 ENOG4108V6E Cell division protein mraZ FOC81_RS24215 ENOG4105C5H ABC transporter FOC81_RS24220 ENOG4105EKE dihydroorotase FOC81_RS24225 ENOG4105CH2 amidohydrolase FOC81_RS24235 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS24240 ENOG410829K Lysine exporter protein (Lyse ygga) FOC81_RS24295 ENOG4105EW9 transcriptional regulator AsnC family FOC81_RS24300 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC81_RS24305 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC81_RS24310 ENOG4105W2Z cytochrome C, class I FOC81_RS24315 ENOG4105C01 Dihydroxy-acid dehydratase FOC81_RS24355 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FOC81_RS24360 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC81_RS24370 ENOG4105EXG Transcriptional regulator FOC81_RS24375 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FOC81_RS24410 ENOG4107YD3 Thioesterase FOC81_RS24415 ENOG4105E02 MotA TolQ exbB proton channel FOC81_RS24430 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FOC81_RS24435 ENOG4105KCK Peptidoglycan-associated lipoprotein FOC81_RS24445 ENOG4105EHG Permease protein FOC81_RS24450 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS24465 ENOG4108YXU transcriptional regulator AsnC family FOC81_RS24475 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOC81_RS24490 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC81_RS24495 ENOG4105T38 integral membrane protein FOC81_RS24505 ENOG41067MG lrgb family FOC81_RS24510 ENOG4105VAW lrga family FOC81_RS24515 ENOG4105CMU LysR family (Transcriptional regulator FOC81_RS24530 ENOG4105CR8 Transcriptional regulator FOC81_RS24545 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FOC81_RS24560 ENOG4105D6U Sodium Glutamate Symporter FOC81_RS24575 ENOG4108UPT UPF0178 protein FOC81_RS24590 ENOG4107RZZ dna polymerase iii epsilon subunit FOC81_RS24595 ENOG4105BZS acriflavin resistance protein FOC81_RS24605 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOC81_RS24610 ENOG4105D1A Methyltransferase FOC81_RS24620 ENOG4105E9H Lytic Murein transglycosylase FOC81_RS24625 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FOC81_RS24645 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC81_RS24660 ENOG41083UI stage II sporulation protein FOC81_RS24665 ENOG4105JGF anti-sigma regulatory factor serine threonine protein kinase FOC81_RS24670 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC81_RS24695 ENOG4105EMN RNA polymerase sigma factor FOC81_RS24730 ENOG4105DD5 Flagellar motor switch protein FOC81_RS24845 ENOG41066XE Type III export protein FOC81_RS24885 ENOG4105ED1 spovr family FOC81_RS24890 ENOG4106AKX UPF0229 protein FOC81_RS24895 ENOG4105CYN Serine protein kinase FOC81_RS24900 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC81_RS24910 ENOG41075H3 AraC family transcriptional regulator FOC81_RS24915 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FOC81_RS24920 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOC81_RS24925 ENOG4105N14 lysine exporter protein LysE YggA FOC81_RS24935 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC81_RS24945 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FOC81_RS24950 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC81_RS24960 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FOC81_RS24965 ENOG4108UJD 30S ribosomal protein S9 FOC81_RS24970 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FOC81_RS24975 ENOG4108IV0 ABC, transporter FOC81_RS24980 ENOG4105C0Z ABC transporter FOC81_RS24985 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC81_RS24990 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS25000 ENOG4105CH5 extracellular solute-binding protein, family 7 FOC81_RS25005 ENOG4105CMS peptidase U62, modulator of DNA gyrase FOC81_RS25010 ENOG4105N42 UPF0307 protein FOC81_RS25030 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC81_RS25035 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC81_RS25040 ENOG4105CD5 CoA-binding domain protein FOC81_RS25045 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FOC81_RS25060 ENOG4105DND Transcriptional regulator FOC81_RS25070 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS25075 ENOG4108YXU transcriptional regulator AsnC family FOC81_RS25085 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC81_RS25090 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC81_RS25100 ENOG4108VIA integral membrane protein FOC81_RS25105 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) FOC81_RS25110 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC81_RS25135 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FOC81_RS25145 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FOC81_RS25150 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC81_RS25155 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FOC81_RS25160 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FOC81_RS25165 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC81_RS25170 ENOG4105DFU Cell wall formation (By similarity) FOC81_RS25175 ENOG4105IPS esterase FOC81_RS25190 ENOG4105DHQ Histidine kinase FOC81_RS25200 ENOG4107Z33 ABC transporter, permease FOC81_RS25215 ENOG4105E2X shikimate dehydrogenase FOC81_RS25220 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase FOC81_RS25230 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC81_RS25240 ENOG4105CDA abc transporter atp-binding protein FOC81_RS25245 ENOG4105DRP amino acid AbC transporter FOC81_RS25250 ENOG4105E5Q amino acid AbC transporter FOC81_RS25255 ENOG4105CT1 (ABC) transporter FOC81_RS25265 ENOG4105JSC dimethylmenaquinone methyltransferase FOC81_RS25275 ENOG4108Z20 Acyl-transferase FOC81_RS25280 ENOG4105CD3 dihydroorotase FOC81_RS25285 ENOG4105CXT aspartate transcarbamylase FOC81_RS25290 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FOC81_RS25295 ENOG4108UJU UPF0301 protein FOC81_RS25300 ENOG4105VCQ rubredoxin FOC81_RS25305 ENOG4105DWF phosphomethylpyrimidine kinase FOC81_RS25310 ENOG4107RZ7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FOC81_RS25315 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FOC81_RS25320 ENOG4105E4C Lytic transglycosylase catalytic FOC81_RS25330 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FOC81_RS25335 ENOG4105D3W isochorismatase FOC81_RS25345 ENOG4105FUY alpha subunit FOC81_RS25385 ENOG4108UKI Enoyl-CoA hydratase FOC81_RS25390 ENOG4105DTD Dehydrogenase FOC81_RS25400 ENOG4105BZU Histidine kinase FOC81_RS25405 ENOG4105BZU Histidine kinase FOC81_RS25425 ENOG4108IV0 ABC, transporter FOC81_RS25430 ENOG4105C0Z ABC transporter FOC81_RS25435 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC81_RS25440 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS25480 ENOG4108IV0 ABC, transporter FOC81_RS25485 ENOG4105C0Z ABC transporter FOC81_RS25490 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS25500 ENOG4105F04 LysR family Transcriptional regulator FOC81_RS25510 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS25545 ENOG4105CBN LysR family transcriptional regulator FOC81_RS25550 ENOG4105CHR reductase FOC81_RS25560 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FOC81_RS25565 ENOG4105BZS acriflavin resistance protein FOC81_RS25580 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) FOC81_RS25585 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC81_RS25605 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FOC81_RS25610 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FOC81_RS25620 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC81_RS25635 ENOG4105CEN a g-specific adenine glycosylase FOC81_RS25650 ENOG4108IV0 ABC, transporter FOC81_RS25655 ENOG4105C0Z ABC transporter FOC81_RS25660 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC81_RS25665 ENOG4108HWW ABC transporter FOC81_RS25680 ENOG4105C7K acetolactate synthase FOC81_RS25685 ENOG4108WYP Transcriptional regulator FOC81_RS25695 ENOG4105F2W methyltransferase FOC81_RS25705 ENOG4105C3R Methionine synthase FOC81_RS25710 ENOG4105D05 Receptor FOC81_RS25715 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FOC81_RS25720 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FOC81_RS25725 ENOG4105DWF phosphomethylpyrimidine kinase FOC81_RS25730 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FOC81_RS25735 ENOG4105DFG type I secretion outer membrane protein FOC81_RS25740 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) FOC81_RS25750 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOC81_RS25765 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC81_RS25770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC81_RS25775 ENOG4105BZU Histidine kinase FOC81_RS25790 ENOG4105UTB Blue (Type 1) copper domain protein FOC81_RS25795 ENOG4105E3B Multicopper oxidase FOC81_RS25810 ENOG4108JQ1 Dehydrogenase FOC81_RS25815 ENOG4107RSM transcriptional regulator FOC81_RS25825 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC81_RS25840 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS25845 ENOG4105EN6 Membrane FOC81_RS25855 ENOG4105EYM Major Facilitator superfamily FOC81_RS25860 ENOG4105DWV Homoserine O-trans-acetylase FOC81_RS25865 ENOG4105DWV Homoserine O-trans-acetylase FOC81_RS25870 ENOG4105FDP GntR family transcriptional regulator FOC81_RS25875 ENOG4105VP7 SAF domain protein FOC81_RS25880 ENOG4105CTX dehydratase FOC81_RS25890 ENOG4108JQ1 Dehydrogenase FOC81_RS25895 ENOG4105DG4 malate L-lactate dehydrogenase FOC81_RS25920 ENOG4105D9M gamma-glutamylcysteine synthetase FOC81_RS25950 ENOG4105ERH Fumarylacetoacetate hydrolase FOC81_RS25965 ENOG41068CG regulatoR FOC81_RS25970 ENOG4105BZU Histidine kinase FOC81_RS25975 ENOG4105BZU Histidine kinase FOC81_RS25980 ENOG4105BZU Histidine kinase FOC81_RS25995 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr FOC81_RS26000 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme FOC81_RS26005 ENOG4108IV0 ABC, transporter FOC81_RS26010 ENOG4105C0Z ABC transporter FOC81_RS26020 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS26030 ENOG4105CHR reductase FOC81_RS26050 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC81_RS26065 ENOG4105KBX Transcriptional regulator, TetR family FOC81_RS26075 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS26080 ENOG41060WC Enoyl-CoA hydratase FOC81_RS26085 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FOC81_RS26095 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS26100 ENOG4105EMY transcriptional regulator FOC81_RS26105 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) FOC81_RS26110 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS26120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS26125 ENOG4105C3U ABC transporter FOC81_RS26130 ENOG4108JQ7 (ABC) transporter FOC81_RS26140 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC81_RS26150 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) FOC81_RS26160 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC81_RS26165 ENOG4105C4R Atp-dependent dna helicase FOC81_RS26170 ENOG4105C25 Primosomal protein n' FOC81_RS26175 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FOC81_RS26185 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FOC81_RS26195 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FOC81_RS26200 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FOC81_RS26205 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOC81_RS26215 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FOC81_RS26220 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) FOC81_RS26240 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS26250 ENOG4106NZI LysR family Transcriptional regulator FOC81_RS26260 ENOG4105RE0 Asp Glu hydantoin racemase FOC81_RS26265 ENOG4105CWB LysR family transcriptional Regulator FOC81_RS26270 ENOG4105F2Z 3-oxoadipate enol-lactonase FOC81_RS26280 ENOG4107QNJ CoA-transferase subunit B FOC81_RS26305 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) FOC81_RS26320 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FOC81_RS26325 ENOG4105CA3 membrane-bound lytic murein transglycosylase FOC81_RS26330 ENOG4105NWN ApaG protein FOC81_RS26340 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC81_RS26350 ENOG4105DDQ anthranilate synthase FOC81_RS26355 ENOG4108I0Q anthranilate phosphoribosyltransferase FOC81_RS26360 ENOG4105DK0 Indole-3-glycerol phosphate synthase FOC81_RS26365 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC81_RS26370 ENOG4105C26 Dehydrogenase FOC81_RS26395 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS26405 ENOG4108KS2 transglutaminase domain protein FOC81_RS26410 ENOG4107ZT5 Thiol disulfide interchange protein FOC81_RS26420 ENOG4105EM7 Selenocysteine-specific translation elongation factor FOC81_RS26430 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) FOC81_RS26435 ENOG4108MG3 formate dehydrogenase FOC81_RS26440 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FOC81_RS26455 ENOG4108S4H thioesterase Superfamily protein FOC81_RS26490 ENOG4108NST exported protein FOC81_RS26495 ENOG4105X1Q TOBE domain protein FOC81_RS26530 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS26580 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FOC81_RS26585 ENOG4105CH2 amidohydrolase FOC81_RS26595 ENOG4105DND Transcriptional regulator FOC81_RS26600 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC81_RS26615 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC81_RS26625 ENOG4105ETS cytosine purines uracil thiamine allantoin FOC81_RS26630 ENOG4105CGP Urocanate hydratase FOC81_RS26635 ENOG41090B9 response to stress FOC81_RS26640 ENOG4105CZE histidine utilization repressor FOC81_RS26655 ENOG4105E2K Glycosyl transferase (Group 1 FOC81_RS26665 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FOC81_RS26670 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FOC81_RS26685 ENOG4107QWB Ornithine cyclodeaminase FOC81_RS26690 ENOG4108YXU transcriptional regulator AsnC family FOC81_RS26700 ENOG4105CIF Ornithine Cyclodeaminase FOC81_RS26715 ENOG4105HEI LysR family (Transcriptional regulator FOC81_RS26720 ENOG4105CV8 reductase FOC81_RS26725 ENOG4107RSM transcriptional regulator FOC81_RS26735 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS26745 ENOG4107Y60 (LipO)protein FOC81_RS26755 ENOG4106B0W Curli production assembly transport component CsgG FOC81_RS26765 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOC81_RS26770 ENOG41068KF Universal stress protein FOC81_RS26775 ENOG4105DU1 integral membrane protein, terc FOC81_RS26780 ENOG4105CSH Transporter FOC81_RS26795 ENOG4108R85 Short chain dehydrogenase FOC81_RS26810 ENOG4108NNI Beta-lactamase domain-containing protein FOC81_RS26815 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FOC81_RS26820 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC81_RS26825 ENOG4105FDP GntR family transcriptional regulator FOC81_RS26835 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FOC81_RS26855 ENOG4108ZRZ Transcriptional regulator (AsnC family) FOC81_RS26865 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC81_RS26870 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC81_RS26875 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FOC81_RS26905 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) FOC81_RS26925 ENOG4107QS1 Cytochrome C Oxidase, Subunit III FOC81_RS26935 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC81_RS26940 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) FOC81_RS26955 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FOC81_RS26960 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC81_RS26990 ENOG4105EIF outer membrane protein W FOC81_RS26995 ENOG4105EGI Transcriptional regulator FOC81_RS27000 ENOG4105CBP Major Facilitator FOC81_RS27010 ENOG4105EA8 2-Nitropropane dioxygenase FOC81_RS27015 ENOG4105DHJ ABC, transporter FOC81_RS27020 ENOG4105CY3 ABC transporter, permease FOC81_RS27025 ENOG4107PE3 Mammalian cell entry related domain protein FOC81_RS27030 ENOG410903C (LipO)protein FOC81_RS27040 ENOG4105DA5 (ABC) transporter FOC81_RS27045 ENOG4105E3A (ABC) transporter FOC81_RS27055 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC81_RS27060 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOC81_RS27065 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC81_RS27070 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC81_RS27075 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOC81_RS27080 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOC81_RS27085 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FOC81_RS27090 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FOC81_RS27095 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FOC81_RS27100 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase FOC81_RS27105 ENOG4107YU2 histidine triad (hIT) protein FOC81_RS27110 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FOC81_RS27115 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FOC81_RS27130 ENOG4105C0H protease FOC81_RS27135 ENOG4107QNR UPF0135 protein FOC81_RS27145 ENOG4105CSH Transporter FOC81_RS27155 ENOG4108S8N class II Aldolase FOC81_RS27160 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FOC81_RS27165 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC81_RS27170 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC81_RS27175 ENOG4105EIX cytochrome c1 FOC81_RS27180 ENOG4107MKT Stringent starvation protein a FOC81_RS27185 ENOG4105KB2 stringent starvation protein b FOC81_RS27215 ENOG4105ETT transcriptional Regulator, LysR family FOC81_RS27225 ENOG4105C9B Cysteine desulfurase FOC81_RS27240 ENOG4105KD1 integral membrane protein FOC81_RS27245 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FOC81_RS27250 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC81_RS27255 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC81_RS27260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS27275 ENOG4106J39 exported protein FOC81_RS27280 ENOG4105C1J atp-dependent rna helicase FOC81_RS27285 ENOG410829K Lysine exporter protein (Lyse ygga) FOC81_RS27290 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FOC81_RS27300 ENOG4108UQY Iron-storage protein FOC81_RS27320 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC81_RS27330 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FOC81_RS27340 ENOG4105ETE Transcriptional regulator (LacI family FOC81_RS27345 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FOC81_RS27350 ENOG4108IJ9 (ABC) transporter FOC81_RS27355 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC81_RS27360 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FOC81_RS27365 ENOG4105DRS transport system, permease FOC81_RS27380 ENOG4108Z2U ureidoglycolate hydrolase FOC81_RS27400 ENOG4105C75 arginyL-tRNA synthetase FOC81_RS27410 ENOG4108Z33 Thiol disulfide Interchange Protein FOC81_RS27420 ENOG4108TKH Nitroreductase FOC81_RS27445 ENOG4105CH2 amidohydrolase FOC81_RS27450 ENOG4105C1G acyl-Coa dehydrogenase FOC81_RS27455 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) FOC81_RS27460 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS27465 ENOG4107QX3 carboxylase FOC81_RS27485 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS27495 ENOG4105C3M thioredoxin reductase FOC81_RS27500 ENOG4105F04 LysR family Transcriptional regulator FOC81_RS27535 ENOG4105D0C transport protein FOC81_RS27540 ENOG4105CXN decarboxylase FOC81_RS27550 ENOG4105D8X mechanosensitive ion channel FOC81_RS27565 ENOG4108Z0Z intracellular protease Pfpi family FOC81_RS27620 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS27625 ENOG4108SF5 RNA Polymerase FOC81_RS27630 ENOG4108S3W Anti-feci sigma factor, fecr FOC81_RS27665 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS27715 ENOG4105CHR reductase FOC81_RS27730 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS27735 ENOG4105C8Y Acetylornithine aminotransferase FOC81_RS27765 ENOG4105H1G trap transporter solute receptor taxi family FOC81_RS27775 ENOG4108RPN Protein smg homolog FOC81_RS27780 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FOC81_RS27790 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC81_RS27805 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FOC81_RS27810 ENOG4105CHR reductase FOC81_RS27820 ENOG4105C7K acetolactate synthase FOC81_RS27825 ENOG4108YXU transcriptional regulator AsnC family FOC81_RS27830 ENOG4105FFC UPF0187 protein FOC81_RS27845 ENOG4105F9N Major Facilitator Superfamily FOC81_RS27860 ENOG4108MEJ flavin reductase domain protein FOC81_RS27875 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC81_RS27885 ENOG4107TFB basic membrane FOC81_RS27890 ENOG4108JQ9 ABC transporter FOC81_RS27895 ENOG4105UIB (ABC) transporter FOC81_RS27905 ENOG4105DZC cytosine deaminase FOC81_RS27910 ENOG4105M4H endoribonuclease L-psp FOC81_RS27935 ENOG4105D38 putrescine abc transporter FOC81_RS27940 ENOG4105F38 ABC transporter, permease FOC81_RS27945 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS27985 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FOC81_RS27995 ENOG4105DMF Dehydrogenase FOC81_RS28010 ENOG4108594 Permease of the drug metabolite transporter FOC81_RS28020 ENOG4105CDA abc transporter atp-binding protein FOC81_RS28025 ENOG4105DRP amino acid AbC transporter FOC81_RS28030 ENOG4105EAD ABC transporter FOC81_RS28035 ENOG4107RP9 extracellular solute-binding protein, family 3 FOC81_RS28040 ENOG4105RQF LysR family Transcriptional regulator FOC81_RS28045 ENOG4107YCY Transcriptional regulator FOC81_RS28055 ENOG4105CSH Transporter FOC81_RS28065 ENOG4107RT4 flavin reductase domain protein FOC81_RS28090 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) FOC81_RS28095 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS28100 ENOG4105CDA abc transporter atp-binding protein FOC81_RS28105 ENOG4106PMH Extracellular solute-binding protein family 3 FOC81_RS28110 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC81_RS28115 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC81_RS28120 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FOC81_RS28125 ENOG4105VG0 50S ribosomal protein l34 FOC81_RS28135 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FOC81_RS28145 ENOG4105CH6 catalase FOC81_RS28170 ENOG4105CH2 amidohydrolase FOC81_RS28175 ENOG4108JQ7 (ABC) transporter FOC81_RS28180 ENOG4105C3U ABC transporter FOC81_RS28185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC81_RS28200 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC81_RS28255 ENOG4105CHM Aminotransferase FOC81_RS28260 ENOG4108KK1 membrane protein AbrB duplication FOC81_RS28265 ENOG4105VEQ Cold shock protein FOC81_RS28270 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FOC81_RS28275 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FOC81_RS28280 ENOG4107QJE Chromosome Partitioning Protein FOC81_RS28290 ENOG4105FA0 parb-like partition protein FOC81_RS28295 ENOG4105HDK L-asparaginase FOC81_RS28300 ENOG4107NQ8 LysR family Transcriptional regulator FOC81_RS28325 ENOG4105E98 transcriptional regulator DeoR family FOC81_RS28340 ENOG4107QKW extracellular solute-binding protein family 1 FOC81_RS28355 ENOG4105C26 Dehydrogenase FOC81_RS28360 ENOG4105C0A alcohol dehydrogenase FOC81_RS28380 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOC81_RS28390 ENOG410683Z Preprotein translocase SecE subunit FOC81_RS28400 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FOC81_RS28405 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FOC81_RS28410 ENOG4108VZM 50s ribosomal protein L10 FOC81_RS28415 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FOC81_RS28420 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC81_RS28425 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC81_RS28440 ENOG4105BZU Histidine kinase FOC81_RS28460 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FOC81_RS28465 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FOC81_RS28470 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FOC81_RS28475 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FOC81_RS28480 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FOC81_RS28485 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FOC81_RS28495 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FOC81_RS28500 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FOC81_RS28505 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FOC81_RS28510 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FOC81_RS28515 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FOC81_RS28520 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FOC81_RS28525 ENOG41084PQ 50s ribosomal protein l29 FOC81_RS28530 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FOC81_RS28540 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC81_RS28550 ENOG4108IV0 ABC, transporter FOC81_RS28555 ENOG4105C0Z ABC transporter FOC81_RS28570 ENOG4108WFR AraC Family Transcriptional Regulator FOC81_RS28580 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC81_RS28595 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FOC81_RS28600 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FOC81_RS28605 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FOC81_RS28610 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FOC81_RS28615 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FOC81_RS28620 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOC81_RS28625 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FOC81_RS28630 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FOC81_RS28635 ENOG4105VPB 50S ribosomal protein L30 FOC81_RS28640 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FOC81_RS28645 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC81_RS28650 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FOC81_RS28660 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FOC81_RS28665 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FOC81_RS28670 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FOC81_RS28675 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FOC81_RS28680 ENOG4108ZT0 50S ribosomal protein l17 FOC81_RS28690 ENOG4105VF7 tolerance protein FOC81_RS28695 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FOC81_RS28705 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein FOC81_RS28710 ENOG4105CHR reductase FOC81_RS28715 ENOG41083Z3 extracellular ligand-binding receptor FOC81_RS28725 ENOG4105C0Z ABC transporter FOC81_RS28730 ENOG4108IV0 ABC, transporter FOC81_RS28740 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC81_RS28745 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FOC81_RS28760 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) FOC81_RS28765 ENOG4105CRE cytochrome C FOC81_RS28780 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC81_RS28790 ENOG4105XQ6 frataxin-like protein FOC81_RS28795 ENOG4108JQC penicillin-binding protein 1A FOC81_RS28800 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FOC81_RS28805 ENOG4105D49 3-dehydroquinate synthase FOC81_RS28810 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein FOC81_RS28815 ENOG4105CH2 amidohydrolase FOC81_RS28825 ENOG4105DND Transcriptional regulator FOC81_RS28830 ENOG4108RXX maleylacetoacetate isomerase FOC81_RS28835 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC81_RS28840 ENOG4107RDB Major Facilitator FOC81_RS28870 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC81_RS28905 ENOG4108KWP DNA-binding transcriptional regulator GlcC FOC81_RS28930 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC81_RS28935 ENOG4108ZGC gaf domain protein FOC81_RS28940 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC81_RS28955 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC81_RS28985 ENOG4105C9M aspartyl-trna synthetase FOC81_RS28990 ENOG4105X23 Endonuclease Exonuclease phosphatase FOC81_RS28995 ENOG4105DZQ phospholipase D Transphosphatidylase FOC81_RS29000 ENOG4107Y9U Membrane FOC81_RS29060 ENOG4105CKK Glycosyl transferase, family 2 FOC81_RS29070 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC81_RS29085 ENOG4105ESV Glycosyl transferase, family 4 FOC81_RS29100 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC81_RS29110 ENOG4105C5E polysaccharide biosynthesis protein FOC81_RS29120 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOC81_RS29125 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC81_RS29130 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FOC81_RS29135 ENOG4105J5G Transferase hexapeptide repeat containing protein FOC81_RS29140 ENOG4107R5Z Oxidoreductase domain protein FOC81_RS29145 ENOG4105EQK -acetyltransferase FOC81_RS29190 ENOG4105D16 lipopolysaccharide heptosyltransferase i FOC81_RS29195 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FOC81_RS29205 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FOC81_RS29215 ENOG4105CY3 ABC transporter, permease FOC81_RS29240 ENOG4105DZ1 carboxypeptidase FOC81_RS29245 ENOG4105F0I Aminotransferase FOC81_RS29255 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FOC81_RS29275 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FOC81_RS29280 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC81_RS29290 ENOG4108WBT adenosyltransferase FOC81_RS29300 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FOC81_RS29305 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FOC81_RS29315 ENOG4105CKI cobalamin synthesis protein FOC81_RS29320 ENOG4105MYN Zinc uptake regulation protein FOC81_RS29325 ENOG4105DIK (ABC) transporter FOC81_RS29330 ENOG4105CC5 ABC transporter FOC81_RS29345 ENOG4105D7X high-affinity nickel-transporter FOC81_RS29350 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC81_RS29360 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FOC81_RS29365 ENOG4105D1S lipid A biosynthesis FOC81_RS29375 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FOC81_RS29380 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS29385 ENOG4105CSH Transporter FOC81_RS29395 ENOG4105EJC lysr family transcriptional regulator FOC81_RS29405 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC81_RS29410 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC81_RS29415 ENOG4105EBM Alpha Beta Hydrolase Fold protein FOC81_RS29425 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FOC81_RS29430 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FOC81_RS29435 ENOG41086DT Membrane protein of unknown function FOC81_RS29440 ENOG4105SYT Methylenetetrahydrofolate reductase FOC81_RS29445 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS29450 ENOG410846T CoA-transferase family III FOC81_RS29455 ENOG4105CI0 Citrate lyase FOC81_RS29495 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC81_RS29500 ENOG4107SC1 transglycosylase FOC81_RS29535 ENOG4105C1J atp-dependent rna helicase FOC81_RS29540 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FOC81_RS29550 ENOG4105ETU transcriptional activator (TenA FOC81_RS29560 ENOG4105K78 MarR family Transcriptional regulator FOC81_RS29580 ENOG4105CSR polyphosphate kinase 2 FOC81_RS29590 ENOG41080HT Transcriptional regulator, arsr family FOC81_RS29610 ENOG4108VCT Sulfite exporter TauE/SafE FOC81_RS29615 ENOG4105DZS Phenylacetate-CoA ligase FOC81_RS29620 ENOG4108IV0 ABC, transporter FOC81_RS29635 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS29640 ENOG4105C0Z ABC transporter FOC81_RS29655 ENOG4105K56 Transcriptional regulator FOC81_RS29660 ENOG4108ZHJ Organic hydroperoxide resistance protein FOC81_RS29665 ENOG4108IV0 ABC, transporter FOC81_RS29670 ENOG4105C0Z ABC transporter FOC81_RS29680 ENOG4105CP9 extracellular ligand-binding receptor FOC81_RS29685 ENOG410810E transcriptional regulator, lysR family FOC81_RS29695 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) FOC81_RS29705 ENOG4105D82 Glutamate dehydrogenase FOC81_RS29710 ENOG4105CCF Lysine exporter protein (Lyse ygga) FOC81_RS29715 ENOG4108MGI Transcriptional regulator FOC81_RS29720 ENOG4105CGK Exodeoxyribonuclease III FOC81_RS29725 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FOC81_RS29740 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS29745 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS29750 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS29760 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOC81_RS29770 ENOG4105CJN penicillin-binding protein FOC81_RS29775 ENOG4105CNI cell division protein FtsW FOC81_RS29780 ENOG4105DG4 malate L-lactate dehydrogenase FOC81_RS29785 ENOG4107QPK )-transporter FOC81_RS29790 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FOC81_RS29800 ENOG4105CAS nag kinase FOC81_RS29805 ENOG4105D01 (LipO)protein FOC81_RS29810 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC81_RS29815 ENOG4105W4M Transport-associated protein FOC81_RS29820 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FOC81_RS29835 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC81_RS29840 ENOG4105K6T rare lipoprotein A FOC81_RS29845 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FOC81_RS29860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC81_RS29865 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FOC81_RS29870 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FOC81_RS29875 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FOC81_RS29880 ENOG4108IUZ ABC transporter FOC81_RS29895 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FOC81_RS29900 ENOG4105C2X Arabinose 5-phosphate isomerase FOC81_RS29905 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FOC81_RS29915 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC81_RS29920 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC81_RS29930 ENOG4108JJ9 ABC, transporter FOC81_RS29935 ENOG4108JJ8 (ABC) transporter FOC81_RS29945 ENOG4105EXG Transcriptional regulator FOC81_RS29955 ENOG4108Z9W Outer membrane porin FOC81_RS29960 ENOG4105C7B Threonine dehydratase FOC81_RS29965 ENOG4105W39 Membrane FOC81_RS29980 ENOG4105VN1 Heat shock protein FOC81_RS29985 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS29990 ENOG4105DFA alanine racemase domain protein FOC81_RS29995 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC81_RS30000 ENOG4107QXX ABC transporter FOC81_RS30010 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC81_RS30015 ENOG4105C79 DNA protecting protein DprA FOC81_RS30020 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC81_RS30025 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FOC81_RS30040 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC81_RS30050 ENOG4108URH decarboxylase FOC81_RS30060 ENOG4105KVH Transcriptional regulator FOC81_RS30070 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) FOC81_RS30080 ENOG4105EQ2 LysR family Transcriptional regulator FOC81_RS30090 ENOG4105C8Q Methyl-accepting chemotaxis FOC81_RS30095 ENOG4105BZU Histidine kinase FOC81_RS30110 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC81_RS30115 ENOG410829K Lysine exporter protein (Lyse ygga) FOC81_RS30120 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC81_RS30130 ENOG4105ES5 Histidine kinase FOC81_RS30135 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC81_RS30140 ENOG4105C1A potassium transporter peripheral membrane FOC81_RS30145 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FOC81_RS30150 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) FOC81_RS30155 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC81_RS30160 ENOG4105MJ2 Competence protein FOC81_RS30165 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC81_RS30175 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FOC81_RS30180 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FOC81_RS30185 ENOG4105VW4 glutaredoxin 3 FOC81_RS30190 ENOG4105C72 UPF0176 protein FOC81_RS30195 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC81_RS30200 ENOG41063SB peptidase FOC81_RS30205 ENOG4105CN1 protease FOC81_RS30210 ENOG4105D06 uba thif-type nad fad binding protein FOC81_RS30215 ENOG4105BZU Histidine kinase FOC81_RS30235 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC81_RS30250 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC81_RS30255 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC81_RS30260 ENOG4105K46 50S ribosomal protein l27 FOC81_RS30265 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FOC81_RS30270 ENOG4105EAH synthase FOC81_RS30290 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FOC81_RS30295 ENOG4105CPU Monooxygenase FOC81_RS30310 ENOG4105CSP Major Facilitator Superfamily FOC81_RS30315 ENOG4105CQB FAD linked oxidase domain protein FOC81_RS30320 ENOG4106IPI cyclase, family FOC81_RS30340 ENOG4105C85 amino acid FOC81_RS30345 ENOG4105ERH Fumarylacetoacetate hydrolase FOC81_RS30355 ENOG4105FDP GntR family transcriptional regulator FOC81_RS30365 ENOG4105E39 Enoyl-CoA hydratase FOC81_RS30370 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC81_RS30400 ENOG4105D2B acyl-CoA dehydrogenase FOC81_RS30420 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS30435 ENOG4108XG2 Histidine kinase FOC81_RS30455 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FOC81_RS30460 ENOG4105CHR reductase FOC81_RS30465 ENOG4105CR4 methylisocitrate lyase FOC81_RS30470 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS30475 ENOG4107QM5 aconitate hydratase FOC81_RS30480 ENOG4105CD3 dihydroorotase FOC81_RS30485 ENOG4108UAU isochorismatase FOC81_RS30490 ENOG4105CKI cobalamin synthesis protein FOC81_RS30505 ENOG4105FDP GntR family transcriptional regulator FOC81_RS30510 ENOG4108IV0 ABC, transporter FOC81_RS30515 ENOG4105C0Z ABC transporter FOC81_RS30530 ENOG41083Z3 extracellular ligand-binding receptor FOC81_RS30535 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FOC81_RS30540 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC81_RS30570 ENOG4105FB2 class II Aldolase FOC81_RS30575 ENOG4105CSP Major Facilitator Superfamily FOC81_RS30580 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FOC81_RS30585 ENOG4105EXW epimerase dehydratase FOC81_RS30590 ENOG4105ZXK Dehydrogenase FOC81_RS30595 ENOG4105G63 Type III effector Hrp-dependent FOC81_RS30600 ENOG41073TP transcriptional regulator FOC81_RS30610 ENOG4105CSH Transporter FOC81_RS30625 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS30635 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FOC81_RS30645 ENOG4105CKI cobalamin synthesis protein FOC81_RS30655 ENOG4105UGU tonB-dependent Receptor FOC81_RS30660 ENOG4105CHR reductase FOC81_RS30670 ENOG4105CHR reductase FOC81_RS30695 ENOG4105C26 Dehydrogenase FOC81_RS30700 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FOC81_RS30710 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS30715 ENOG4105C0Z ABC transporter FOC81_RS30720 ENOG4108IV0 ABC, transporter FOC81_RS30725 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS30730 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC81_RS30735 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FOC81_RS30740 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS30775 ENOG4105EMN RNA polymerase sigma factor FOC81_RS30780 ENOG4105C59 p-type ATPase FOC81_RS30795 ENOG4105BZ1 (ABC) transporter FOC81_RS30805 ENOG4105EGS Mechanosensitive ion channel FOC81_RS30820 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC81_RS30825 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC81_RS30835 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FOC81_RS30840 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FOC81_RS30850 ENOG4105CEY Amp-dependent synthetase and ligase FOC81_RS30895 ENOG4108U78 Glutathione S-transferase FOC81_RS30930 ENOG4105F2Z 3-oxoadipate enol-lactonase FOC81_RS30945 ENOG4107QNJ CoA-transferase subunit B FOC81_RS30955 ENOG4107HP6 Transcriptional regulator FOC81_RS30960 ENOG4105CHR reductase FOC81_RS30965 ENOG4105CRW Short chain fatty acid transporter FOC81_RS30970 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC81_RS30975 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) FOC81_RS30980 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FOC81_RS30995 ENOG4105DUM transcriptional regulator, lysR family FOC81_RS31000 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FOC81_RS31010 ENOG4105C01 Dihydroxy-acid dehydratase FOC81_RS31020 ENOG4105HEI LysR family (Transcriptional regulator FOC81_RS31025 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC81_RS31040 ENOG4108JYK Dehydrogenase FOC81_RS31045 ENOG4108R85 Short chain dehydrogenase FOC81_RS31050 ENOG4108IV0 ABC, transporter FOC81_RS31055 ENOG4105C0Z ABC transporter FOC81_RS31065 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS31075 ENOG4105E2X shikimate dehydrogenase FOC81_RS31085 ENOG4105JXH GntR family transcriptional regulator FOC81_RS31095 ENOG4105GP2 5'(3')-deoxyribonucleotidase FOC81_RS31110 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC81_RS31115 ENOG4105CAK Cell division ATP-binding protein ftsE FOC81_RS31120 ENOG4107QXX ABC transporter FOC81_RS31125 ENOG4105EZ7 amino acid ABC transporter FOC81_RS31130 ENOG4105DRP amino acid AbC transporter FOC81_RS31135 ENOG4105CDA abc transporter atp-binding protein FOC81_RS31140 ENOG4105CHU acetyl-coa acetyltransferase FOC81_RS31150 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FOC81_RS31170 ENOG4107HP6 Transcriptional regulator FOC81_RS31190 ENOG4108IV0 ABC, transporter FOC81_RS31200 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FOC81_RS31205 ENOG4105C32 Amino acid ABC transporter (Permease) FOC81_RS31215 ENOG4105MSY salicylate hydroxylase FOC81_RS31220 ENOG4105CBX hi0933 family FOC81_RS31225 ENOG4105JN3 extra-cytoplasmic solute receptor family protein FOC81_RS31230 ENOG4105CQC Prephenate dehydratase FOC81_RS31270 ENOG4105ENT Efflux transporter rnd family, mfp subunit FOC81_RS31275 ENOG4105CBN LysR family transcriptional regulator FOC81_RS31280 ENOG4105IPI Membrane FOC81_RS31285 ENOG4105EV8 ectoine hydroxylase FOC81_RS31295 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC81_RS31300 ENOG4105F38 ABC transporter, permease FOC81_RS31305 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC81_RS31315 ENOG4105CQB FAD linked oxidase domain protein FOC81_RS31325 ENOG4105II7 pyrroline-5-carboxylate reductase FOC81_RS31345 ENOG4105NTW Transcriptional regulator FOC81_RS31375 ENOG4105I6B RNA polymerase FOC81_RS31380 ENOG4105WH1 Two component transcriptional regulator luxr family FOC81_RS31385 ENOG4105ES5 Histidine kinase FOC81_RS31440 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FOC81_RS31445 ENOG4105CNN ABC, transporter FOC81_RS31455 ENOG4105C2J ABC transporter FOC81_RS31460 ENOG4105MSY salicylate hydroxylase FOC81_RS31470 ENOG4108M0I Transcriptional regulator FOC81_RS31475 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC81_RS31480 ENOG4107RRE RNA-directed DNA polymerase FOC81_RS31505 ENOG4107QXX ABC transporter FOC81_RS31525 ENOG4108SF5 RNA Polymerase FOC81_RS31535 ENOG4105E0K tonB-dependent siderophore receptor FOC81_RS31545 ENOG4105DRR Transcriptional regulator, GntR family FOC81_RS31555 ENOG4105E5Q amino acid AbC transporter FOC81_RS31560 ENOG4105CDA abc transporter atp-binding protein FOC81_RS31565 ENOG4105CT1 (ABC) transporter FOC81_RS31570 ENOG4105CTX dehydratase FOC81_RS31585 ENOG4105EMU Dehydrogenase FOC81_RS31600 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FOC81_RS31690 ENOG4105VEQ Cold shock protein FOC81_RS31805 ENOG4105CAR Terminase, large subunit FOC81_RS32000 ENOG4105VEQ Cold shock protein