locus-tag	class	description
APT56_RS00005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APT56_RS00010	COG0085	RNA polymerase activity
APT56_RS00015	COG0222	ribosome binding
APT56_RS00020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APT56_RS00025	COG0081	regulation of translation
APT56_RS00030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APT56_RS00040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APT56_RS00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APT56_RS00090	COG1840	ABC-type Fe3 transport system, periplasmic component
APT56_RS00095	COG3842	ATPase activity
APT56_RS00105	COG1349	DNA-binding transcription factor activity
APT56_RS00130	COG0583	DNA-binding transcription factor activity
APT56_RS00135	COG0252	asparaginase activity
APT56_RS00140	COG1475	DNA binding
APT56_RS00150	COG1192	Involved in chromosome partitioning
APT56_RS00155	COG0357	Ribosomal RNA small subunit methyltransferase G
APT56_RS00160	COG0445	tRNA wobble uridine modification
APT56_RS00165	COG1278	Cold shock
APT56_RS00170	COG3180	Ammonia monooxygenase
APT56_RS00175	COG0436	Aminotransferase
APT56_RS00195	COG2205	protein histidine kinase activity
APT56_RS00205	COG0038	chloride channel
APT56_RS00215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APT56_RS00225	COG0601	transmembrane transport
APT56_RS00230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS00235	COG0444	Belongs to the ABC transporter superfamily
APT56_RS00240	COG4608	Belongs to the ABC transporter superfamily
APT56_RS00245	COG1473	amidohydrolase
APT56_RS00250	COG2175	clavaminate synthase activity
APT56_RS00265	COG0753	catalase activity
APT56_RS00275	COG0594	ribonuclease P activity
APT56_RS00280	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APT56_RS00285	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APT56_RS00290	COG0592	DNA-directed DNA polymerase activity
APT56_RS00300	COG0583	DNA-binding transcription factor activity
APT56_RS00325	COG1574	metal-dependent hydrolase with the TIM-barrel fold
APT56_RS00335	COG0583	DNA-binding transcription factor activity
APT56_RS00340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS00345	COG0765	amino acid transport
APT56_RS00350	COG0765	amino acid transport
APT56_RS00355	COG1126	abc transporter atp-binding protein
APT56_RS00390	COG3842	ATPase activity
APT56_RS00395	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT56_RS00400	COG1177	transmembrane transport
APT56_RS00415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_RS00455	COG1609	Transcriptional regulator
APT56_RS00465	COG3842	ATPase activity
APT56_RS00470	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT56_RS00475	COG1177	transmembrane transport
APT56_RS00500	COG0251	oxidation-reduction process
APT56_RS00510	COG3210	domain, Protein
APT56_RS00530	COG0402	S-adenosylhomocysteine deaminase activity
APT56_RS00540	COG4603	Belongs to the binding-protein-dependent transport system permease family
APT56_RS00545	COG3845	ABC transporter
APT56_RS00550	COG1744	ABC transporter substrate-binding protein PnrA-like
APT56_RS00560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APT56_RS00575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT56_RS00590	COG2814	Major facilitator Superfamily
APT56_RS00605	COG3781	membrane
APT56_RS00610	COG1522	sequence-specific DNA binding
APT56_RS00615	COG0028	Belongs to the TPP enzyme family
APT56_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS00625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_RS00650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT56_RS00655	COG2922	Belongs to the Smg family
APT56_RS00665	COG2358	TRAP transporter, solute receptor (TAXI family
APT56_RS00680	COG0765	amino acid transport
APT56_RS00685	COG0765	amino acid transport
APT56_RS00690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS00695	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS00700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APT56_RS00730	COG4977	sequence-specific DNA binding
APT56_RS00750	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
APT56_RS00765	COG3339	Conserved Protein
APT56_RS00775	COG1280	lysine exporter protein (LysE YggA)
APT56_RS00795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_RS00820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
APT56_RS00825	COG0183	Belongs to the thiolase family
APT56_RS00830	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
APT56_RS00835	COG1960	acyl-CoA dehydrogenase activity
APT56_RS00840	COG1473	amidohydrolase
APT56_RS00855	COG1742	UPF0060 membrane protein
APT56_RS00870	COG1280	lysine exporter protein (LysE YggA)
APT56_RS00895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APT56_RS00905	COG0018	arginyl-trna synthetase
APT56_RS00920	COG0395	ABC-type sugar transport system, permease component
APT56_RS00925	COG1175	transmembrane transport
APT56_RS00930	COG1653	transport
APT56_RS00935	COG3842	ATPase activity
APT56_RS00940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT56_RS00945	COG1609	Transcriptional regulator
APT56_RS00955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT56_RS00970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APT56_RS00980	COG0583	DNA-binding transcription factor activity
APT56_RS01000	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APT56_RS01005	COG1280	lysine exporter protein (LysE YggA)
APT56_RS01010	COG0513	Belongs to the DEAD box helicase family
APT56_RS01015	COG5339	Protein conserved in bacteria
APT56_RS01020	COG5339	Protein conserved in bacteria
APT56_RS01025	COG1228	amidohydrolase
APT56_RS01035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS01040	COG0601	transmembrane transport
APT56_RS01045	COG0747	negative chemotaxis
APT56_RS01060	COG3708	Transcriptional regulator
APT56_RS01060	COG2207	Transcriptional regulator
APT56_RS01070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APT56_RS01080	COG0583	DNA-binding transcription factor activity
APT56_RS01125	COG2969	positive regulation of protein catabolic process
APT56_RS01130	COG0625	glutathione transferase activity
APT56_RS01135	COG2857	Cytochrome c1
APT56_RS01140	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APT56_RS01145	COG0723	plastoquinol--plastocyanin reductase activity
APT56_RS01150	COG1970	mechanosensitive ion channel activity
APT56_RS01155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APT56_RS01170	COG0805	protein transport
APT56_RS01175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APT56_RS01180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APT56_RS01185	COG0537	adenosine 5'-monophosphoramidase activity
APT56_RS01190	COG0140	phosphoribosyl-ATP diphosphatase activity
APT56_RS01195	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APT56_RS01200	COG0107	imidazoleglycerol-phosphate synthase activity
APT56_RS01205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APT56_RS01210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APT56_RS01215	COG0131	Imidazoleglycerol-phosphate dehydratase
APT56_RS01220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APT56_RS01225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APT56_RS01230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APT56_RS01235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APT56_RS01245	COG0842	Transport permease protein
APT56_RS01250	COG1131	(ABC) transporter
APT56_RS01260	COG2853	Lipoprotein
APT56_RS01265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APT56_RS01270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APT56_RS01275	COG1127	ABC transporter
APT56_RS01290	COG0477	Major facilitator Superfamily
APT56_RS01305	COG0583	DNA-binding transcription factor activity
APT56_RS01310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
APT56_RS01315	COG0511	ligase activity, forming carbon-carbon bonds
APT56_RS01330	COG1984	allophanate hydrolase subunit 2
APT56_RS01345	COG2059	Chromate
APT56_RS01355	COG0070	glutamate synthase
APT56_RS01355	COG0069	glutamate synthase activity
APT56_RS01355	COG0067	glutamate synthase
APT56_RS01380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT56_RS01400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APT56_RS01410	COG1845	cytochrome c oxidase, subunit III
APT56_RS01430	COG1612	heme a metabolic process
APT56_RS01440	COG1999	signal sequence binding
APT56_RS01460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APT56_RS01465	COG2814	Major facilitator Superfamily
APT56_RS01490	COG0456	acetyltransferase
APT56_RS01530	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APT56_RS01540	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APT56_RS01545	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
APT56_RS01550	COG2814	Major facilitator Superfamily
APT56_RS01555	COG0583	DNA-binding transcription factor activity
APT56_RS01560	COG2423	ornithine cyclodeaminase activity
APT56_RS01565	COG5001	Diguanylate cyclase
APT56_RS01570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APT56_RS01575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APT56_RS01585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APT56_RS01595	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APT56_RS01600	COG0463	Glycosyl transferase, family 2
APT56_RS01640	COG0737	Belongs to the 5'-nucleotidase family
APT56_RS01665	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
APT56_RS01670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
APT56_RS01690	COG0840	transmembrane signaling receptor activity
APT56_RS01695	COG2814	Major facilitator Superfamily
APT56_RS01710	COG3188	usher protein
APT56_RS01770	COG1802	Transcriptional regulator
APT56_RS01780	COG3069	C4-dicarboxylate transmembrane transporter activity
APT56_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
APT56_RS01800	COG0589	response to stress
APT56_RS01805	COG4172	Belongs to the ABC transporter superfamily
APT56_RS01810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS01820	COG0747	negative chemotaxis
APT56_RS01845	COG1464	Belongs to the NlpA lipoprotein family
APT56_RS01850	COG0431	NADPH-dependent FMN reductase
APT56_RS01855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_RS01860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT56_RS01865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_RS01880	COG2011	ABC-type metal ion transport system permease component
APT56_RS01885	COG1464	Belongs to the NlpA lipoprotein family
APT56_RS01890	COG1116	anion transmembrane transporter activity
APT56_RS01895	COG3585	molybdate ion transport
APT56_RS01915	COG1607	acyl-coa hydrolase
APT56_RS01925	COG3383	formate dehydrogenase (NAD+) activity
APT56_RS01925	COG0243	molybdopterin cofactor binding
APT56_RS01930	COG3383	formate dehydrogenase (NAD+) activity
APT56_RS01930	COG0243	molybdopterin cofactor binding
APT56_RS01935	COG0437	4 iron, 4 sulfur cluster binding
APT56_RS01940	COG2864	formate dehydrogenase
APT56_RS01955	COG3276	selenocysteine insertion sequence binding
APT56_RS01965	COG1215	transferase activity, transferring glycosyl groups
APT56_RS01970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_RS01975	COG1305	Transglutaminase-like
APT56_RS01980	COG0709	Synthesizes selenophosphate from selenide and ATP
APT56_RS02010	COG1012	belongs to the aldehyde dehydrogenase family
APT56_RS02015	COG3284	Transcriptional regulator
APT56_RS02020	COG0134	indole-3-glycerol-phosphate synthase activity
APT56_RS02025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APT56_RS02030	COG0512	Glutamine amidotransferase of anthranilate synthase
APT56_RS02040	COG0546	phosphoglycolate phosphatase activity
APT56_RS02045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APT56_RS02050	COG2967	ApaG domain
APT56_RS02060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT56_RS02070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT56_RS02075	COG0037	tRNA processing
APT56_RS02090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT56_RS02095	COG0583	DNA-binding transcription factor activity
APT56_RS02100	COG3473	Maleate cis-trans isomerase
APT56_RS02105	COG0583	DNA-binding transcription factor activity
APT56_RS02120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APT56_RS02130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT56_RS02135	COG1024	Enoyl-CoA hydratase
APT56_RS02150	COG0356	it plays a direct role in the translocation of protons across the membrane
APT56_RS02165	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APT56_RS02170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APT56_RS02175	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
APT56_RS02185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APT56_RS02195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APT56_RS02200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APT56_RS02205	COG0210	DNA helicase
APT56_RS02220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APT56_RS02225	COG4221	oxidoreductase activity
APT56_RS02235	COG2171	N-acyltransferase activity
APT56_RS02245	COG2195	Cleaves the N-terminal amino acid of tripeptides
APT56_RS02255	COG4608	Belongs to the ABC transporter superfamily
APT56_RS02260	COG0444	Belongs to the ABC transporter superfamily
APT56_RS02270	COG0601	transmembrane transport
APT56_RS02275	COG0747	negative chemotaxis
APT56_RS02280	COG2988	succinylglutamate desuccinylase activity
APT56_RS02290	COG0583	DNA-binding transcription factor activity
APT56_RS02295	COG0747	negative chemotaxis
APT56_RS02305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APT56_RS02310	COG1024	Enoyl-CoA hydratase
APT56_RS02315	COG1024	Enoyl-CoA hydratase
APT56_RS02325	COG1309	transcriptional regulator
APT56_RS02340	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_RS02365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_RS02370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_RS02385	COG0179	Fumarylacetoacetate (FAA) hydrolase
APT56_RS02405	COG1129	ABC transporter
APT56_RS02420	COG1802	Transcriptional regulator
APT56_RS02430	COG0583	DNA-binding transcription factor activity
APT56_RS02440	COG2988	succinylglutamate desuccinylase activity
APT56_RS02450	COG2918	glutathione biosynthetic process
APT56_RS02485	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APT56_RS02490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT56_RS02500	COG2721	sulfolactate sulfo-lyase activity
APT56_RS02505	COG2721	sulfolactate sulfo-lyase activity
APT56_RS02510	COG2188	Transcriptional regulator
APT56_RS02515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT56_RS02520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT56_RS02520	COG2813	Specifically methylates the guanine in position
APT56_RS02525	COG2223	nitrite transmembrane transporter activity
APT56_RS02535	COG2860	membrane
APT56_RS02540	COG1802	Transcriptional regulator
APT56_RS02550	COG1984	allophanate hydrolase subunit 2
APT56_RS02555	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APT56_RS02575	COG1247	-acetyltransferase
APT56_RS02590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT56_RS02605	COG2132	Multicopper oxidase
APT56_RS02630	COG0745	RESPONSE REGULATOR receiver
APT56_RS02635	COG2226	methyltransferase
APT56_RS02650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APT56_RS02660	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APT56_RS02670	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APT56_RS02675	COG0351	phosphomethylpyrimidine kinase
APT56_RS02680	COG2022	thiamine diphosphate biosynthetic process
APT56_RS02685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APT56_RS02690	COG4771	TonB-dependent receptor
APT56_RS02700	COG2186	Transcriptional regulator
APT56_RS02715	COG1063	alcohol dehydrogenase
APT56_RS02725	COG0765	amino acid transport
APT56_RS02730	COG1126	abc transporter atp-binding protein
APT56_RS02735	COG4948	Mandelate Racemase Muconate Lactonizing
APT56_RS02740	COG0246	Mannitol dehydrogenase
APT56_RS02755	COG1194	a g-specific adenine glycosylase
APT56_RS02780	COG2177	Part of the ABC transporter FtsEX involved in
APT56_RS02785	COG2884	Cell division ATP-binding protein ftsE
APT56_RS02790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS02795	COG4597	amino acid ABC transporter
APT56_RS02800	COG0765	amino acid transport
APT56_RS02805	COG1126	abc transporter atp-binding protein
APT56_RS02825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT56_RS02830	COG2081	HI0933 family
APT56_RS02840	COG1605	Chorismate mutase
APT56_RS02840	COG0077	Prephenate dehydratase
APT56_RS02875	COG0477	Major facilitator Superfamily
APT56_RS02885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
APT56_RS02890	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APT56_RS02910	COG0237	dephospho-CoA kinase activity
APT56_RS02915	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
APT56_RS02945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_RS02950	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APT56_RS02965	COG3833	ABC-type maltose transport systems, permease component
APT56_RS02970	COG1175	transmembrane transport
APT56_RS02975	COG3842	ATPase activity
APT56_RS02995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APT56_RS03030	COG0410	ABC transporter
APT56_RS03065	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS03070	COG1024	Enoyl-CoA hydratase
APT56_RS03110	COG4638	Rieske (2fe-2S)
APT56_RS03115	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
APT56_RS03120	COG1335	isochorismatase
APT56_RS03125	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS03135	COG0741	lytic transglycosylase activity
APT56_RS03140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APT56_RS03145	COG0352	thiamine-phosphate diphosphorylase activity
APT56_RS03160	COG1678	Uncharacterized ACR, COG1678
APT56_RS03165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APT56_RS03185	COG1126	abc transporter atp-binding protein
APT56_RS03190	COG0765	amino acid transport
APT56_RS03200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS03205	COG0436	Aminotransferase
APT56_RS03210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APT56_RS03220	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APT56_RS03230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APT56_RS03235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APT56_RS03245	COG3842	ATPase activity
APT56_RS03250	COG1175	transmembrane transport
APT56_RS03270	COG0557	exoribonuclease II activity
APT56_RS03275	COG3150	esterase
APT56_RS03280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APT56_RS03285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_RS03290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APT56_RS03295	COG0511	ligase activity, forming carbon-carbon bonds
APT56_RS03300	COG0439	Biotin carboxylase
APT56_RS03305	COG2264	protein methyltransferase activity
APT56_RS03315	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APT56_RS03315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APT56_RS03340	COG1696	Membrane protein involved in D-alanine export
APT56_RS03345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APT56_RS03375	COG1522	sequence-specific DNA binding
APT56_RS03380	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS03390	COG0583	DNA-binding transcription factor activity
APT56_RS03405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT56_RS03410	COG0045	succinate-CoA ligase (ADP-forming) activity
APT56_RS03410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT56_RS03410	COG1042	CoA-binding domain protein
APT56_RS03415	COG1335	isochorismatase
APT56_RS03420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_RS03425	COG1116	anion transmembrane transporter activity
APT56_RS03440	COG3028	Belongs to the UPF0307 family
APT56_RS03445	COG0312	modulator of DNA gyrase
APT56_RS03450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
APT56_RS03460	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_RS03465	COG4177	L-phenylalanine transmembrane transporter activity
APT56_RS03480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APT56_RS03485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APT56_RS03490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APT56_RS03500	COG0316	Belongs to the HesB IscA family
APT56_RS03515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APT56_RS03525	COG1280	lysine exporter protein (LysE YggA)
APT56_RS03530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APT56_RS03535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APT56_RS03550	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APT56_RS03550	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APT56_RS03565	COG2766	serine protein kinase
APT56_RS03570	COG2718	Belongs to the UPF0229 family
APT56_RS03575	COG2719	SpoVR family
APT56_RS03585	COG0583	DNA-binding transcription factor activity
APT56_RS03590	COG1942	4-Oxalocrotonate Tautomerase
APT56_RS03600	COG0456	acetyltransferase
APT56_RS03610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APT56_RS03665	COG4789	Type iii secretion
APT56_RS03740	COG4669	(LipO)protein
APT56_RS03770	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APT56_RS03775	COG4790	Type iii secretion
APT56_RS03780	COG4794	Type iii secretion
APT56_RS03785	COG4791	protein targeting
APT56_RS03790	COG4792	protein secretion
APT56_RS03820	COG2208	phosphoserine phosphatase activity
APT56_RS03820	COG2770	Histidine kinase
APT56_RS03830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APT56_RS03835	COG2172	sigma factor antagonist activity
APT56_RS03840	COG1366	Belongs to the anti-sigma-factor antagonist family
APT56_RS03880	COG1388	LysM domain
APT56_RS03880	COG0741	lytic transglycosylase activity
APT56_RS03885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APT56_RS03890	COG2226	methyltransferase
APT56_RS03895	COG0328	RNA-DNA hybrid ribonuclease activity
APT56_RS03905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_RS03920	COG1671	Belongs to the UPF0178 family
APT56_RS03935	COG0786	glutamate:sodium symporter activity
APT56_RS03945	COG0463	Glycosyl transferase, family 2
APT56_RS03950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APT56_RS03965	COG0583	DNA-binding transcription factor activity
APT56_RS03985	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_RS04005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_RS04015	COG0583	DNA-binding transcription factor activity
APT56_RS04020	COG1380	Effector of murein hydrolase LrgA
APT56_RS04035	COG0697	spore germination
APT56_RS04040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_RS04055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APT56_RS04065	COG1522	sequence-specific DNA binding
APT56_RS04080	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
APT56_RS04085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_RS04100	COG0823	Involved in the tonB-independent uptake of proteins
APT56_RS04110	COG0848	biopolymer transport protein
APT56_RS04115	COG0811	peptide transport
APT56_RS04120	COG0824	Thioesterase
APT56_RS04125	COG0442	prolyl-tRNA aminoacylation
APT56_RS04155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT56_RS04170	COG2084	Dehydrogenase
APT56_RS04175	COG0405	Gamma-glutamyltransferase
APT56_RS04215	COG0129	dihydroxy-acid dehydratase activity
APT56_RS04220	COG4654	Cytochrome c, class I
APT56_RS04225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT56_RS04235	COG1522	sequence-specific DNA binding
APT56_RS04280	COG1473	amidohydrolase
APT56_RS04285	COG0418	dihydroorotase activity
APT56_RS04290	COG0488	(ABC) transporter
APT56_RS04300	COG2001	Belongs to the MraZ family
APT56_RS04305	COG0275	rRNA processing
APT56_RS04310	COG3116	cell division
APT56_RS04320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT56_RS04325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APT56_RS04330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APT56_RS04340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APT56_RS04345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APT56_RS04350	COG1181	Belongs to the D-alanine--D-alanine ligase family
APT56_RS04355	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APT56_RS04365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APT56_RS04370	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APT56_RS04380	COG0739	heme binding
APT56_RS04385	COG0653	protein targeting
APT56_RS04400	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS04405	COG0028	Belongs to the TPP enzyme family
APT56_RS04415	COG0300	oxidoreductase activity
APT56_RS04420	COG1522	sequence-specific DNA binding
APT56_RS04435	COG2239	Acts as a magnesium transporter
APT56_RS04445	COG2855	membrane
APT56_RS04450	COG0583	DNA-binding transcription factor activity
APT56_RS04455	COG1473	amidohydrolase
APT56_RS04460	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_RS04465	COG0483	inositol monophosphate 1-phosphatase activity
APT56_RS04470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_RS04470	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
APT56_RS04475	COG1501	Belongs to the glycosyl hydrolase 31 family
APT56_RS04480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APT56_RS04485	COG2011	ABC-type metal ion transport system permease component
APT56_RS04510	COG0840	transmembrane signaling receptor activity
APT56_RS04515	COG0583	DNA-binding transcription factor activity
APT56_RS04525	COG0735	belongs to the Fur family
APT56_RS04545	COG2818	Glycosylase
APT56_RS04550	COG1368	sulfuric ester hydrolase activity
APT56_RS04555	COG2982	Protein involved in outer membrane biogenesis
APT56_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS04600	COG2154	pterin-4-alpha-carbinolamine dehydratase
APT56_RS04625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APT56_RS04640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT56_RS04645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APT56_RS04650	COG1929	Belongs to the glycerate kinase type-1 family
APT56_RS04655	COG0469	pyruvate kinase activity
APT56_RS04660	COG0700	Nucleoside recognition
APT56_RS04665	COG1960	acyl-CoA dehydrogenase activity
APT56_RS04670	COG0242	peptide deformylase activity
APT56_RS04690	COG0204	Acyl-transferase
APT56_RS04695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APT56_RS04700	COG0751	glycine-tRNA ligase activity
APT56_RS04705	COG0752	glycyl-tRNA synthetase alpha subunit
APT56_RS04710	COG1024	Enoyl-CoA hydratase
APT56_RS04725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_RS04730	COG2030	dehydratase
APT56_RS04735	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS04755	COG2070	2-Nitropropane dioxygenase
APT56_RS04765	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_RS04770	COG0183	Belongs to the thiolase family
APT56_RS04780	COG1960	acyl-CoA dehydrogenase activity
APT56_RS04785	COG1960	acyl-CoA dehydrogenase activity
APT56_RS04790	COG1024	Enoyl-CoA hydratase
APT56_RS04800	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
APT56_RS04810	COG2301	Belongs to the HpcH HpaI aldolase family
APT56_RS04815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APT56_RS04825	COG0617	tRNA 3'-terminal CCA addition
APT56_RS04840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APT56_RS04850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APT56_RS04855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APT56_RS04860	COG0586	Pfam SNARE associated Golgi protein
APT56_RS04870	COG0860	N-Acetylmuramoyl-L-alanine amidase
APT56_RS04875	COG0114	fumarate hydratase activity
APT56_RS04885	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS04900	COG0531	amino acid
APT56_RS04905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_RS04910	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS04915	COG1960	acyl-CoA dehydrogenase activity
APT56_RS04920	COG0583	DNA-binding transcription factor activity
APT56_RS04930	COG0579	oxidoreductase
APT56_RS04935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT56_RS04940	COG0259	pyridoxamine-phosphate oxidase activity
APT56_RS04955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_RS04960	COG0577	efflux transmembrane transporter activity
APT56_RS04960	COG1136	(ABC) transporter
APT56_RS04965	COG1538	Outer membrane efflux protein
APT56_RS04970	COG0583	DNA-binding transcription factor activity
APT56_RS04980	COG1136	(ABC) transporter
APT56_RS04985	COG1136	(ABC) transporter
APT56_RS04985	COG0577	efflux transmembrane transporter activity
APT56_RS04995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_RS05000	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APT56_RS05035	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APT56_RS05045	COG0800	Aldolase
APT56_RS05060	COG1216	Glycosyl transferase, family 2
APT56_RS05060	COG0463	Glycosyl transferase, family 2
APT56_RS05085	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS05090	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
APT56_RS05110	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
APT56_RS05115	COG4638	Rieske (2fe-2S)
APT56_RS05140	COG0747	negative chemotaxis
APT56_RS05145	COG0601	transmembrane transport
APT56_RS05150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS05155	COG0444	Belongs to the ABC transporter superfamily
APT56_RS05160	COG4608	Belongs to the ABC transporter superfamily
APT56_RS05180	COG2746	aminoglycoside 3-N-acetyltransferase activity
APT56_RS05185	COG0488	(ABC) transporter
APT56_RS05205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APT56_RS05210	COG2894	cell division
APT56_RS05215	COG0850	regulation of cytokinetic process
APT56_RS05220	COG1414	Transcriptional regulator
APT56_RS05230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_RS05240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APT56_RS05250	COG1294	oxidase, subunit
APT56_RS05255	COG0514	ATP-dependent DNA helicase (RecQ)
APT56_RS05275	COG2255	four-way junction helicase activity
APT56_RS05285	COG1090	epimerase
APT56_RS05290	COG0632	four-way junction helicase activity
APT56_RS05315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APT56_RS05325	COG0006	proline dipeptidase activity
APT56_RS05345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_RS05360	COG4783	chaperone-mediated protein folding
APT56_RS05400	COG2814	Major facilitator Superfamily
APT56_RS05415	COG0513	Belongs to the DEAD box helicase family
APT56_RS05430	COG1058	Belongs to the CinA family
APT56_RS05430	COG1546	Belongs to the CinA family
APT56_RS05435	COG1414	Transcriptional regulator
APT56_RS05450	COG0167	dihydroorotate dehydrogenase activity
APT56_RS05455	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
APT56_RS05460	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APT56_RS05470	COG0583	DNA-binding transcription factor activity
APT56_RS05525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
APT56_RS05550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT56_RS05555	COG0735	belongs to the Fur family
APT56_RS05560	COG0497	DNA recombination
APT56_RS05570	COG1420	regulation of RNA biosynthetic process
APT56_RS05575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APT56_RS05585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APT56_RS05595	COG0443	Heat shock 70 kDa protein
APT56_RS05600	COG0484	heat shock protein binding
APT56_RS05610	COG0612	Peptidase, M16
APT56_RS05635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT56_RS05665	COG3307	-O-antigen
APT56_RS05670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_RS05685	COG0745	RESPONSE REGULATOR receiver
APT56_RS05690	COG2205	protein histidine kinase activity
APT56_RS05695	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
APT56_RS05700	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
APT56_RS05705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
APT56_RS05720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APT56_RS05730	COG1193	negative regulation of DNA recombination
APT56_RS05735	COG0492	ferredoxin-NADP+ reductase activity
APT56_RS05740	COG1674	ftsk spoiiie
APT56_RS05745	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
APT56_RS05750	COG0251	oxidation-reduction process
APT56_RS05755	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APT56_RS05760	COG0517	IMP dehydrogenase activity
APT56_RS05760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APT56_RS05780	COG0601	transmembrane transport
APT56_RS05795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT56_RS05800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APT56_RS05805	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APT56_RS05840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_RS05860	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS05865	COG3022	response to hydroperoxide
APT56_RS05870	COG1289	transmembrane transporter activity
APT56_RS05875	COG0028	Belongs to the TPP enzyme family
APT56_RS05880	COG0440	acetolactate synthase activity
APT56_RS05885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APT56_RS05890	COG1183	phosphatidylcholine synthase activity
APT56_RS05900	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APT56_RS05905	COG1185	polyribonucleotide nucleotidyltransferase activity
APT56_RS05915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APT56_RS05990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_RS06000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT56_RS06020	COG0149	triose-phosphate isomerase activity
APT56_RS06025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APT56_RS06105	COG1595	DNA-templated transcription, initiation
APT56_RS06110	COG3712	iron ion homeostasis
APT56_RS06130	COG1595	DNA-templated transcription, initiation
APT56_RS06140	COG4206	TonB-dependent receptor
APT56_RS06140	COG1629	transport
APT56_RS06150	COG0642	Histidine kinase
APT56_RS06165	COG2851	Citrate transporter
APT56_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS06190	COG1278	Cold shock
APT56_RS06205	COG3813	Protein conserved in bacteria
APT56_RS06210	COG2354	Protein conserved in bacteria
APT56_RS06225	COG4772	TonB-dependent receptor
APT56_RS06230	COG1522	sequence-specific DNA binding
APT56_RS06260	COG0747	negative chemotaxis
APT56_RS06280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_RS06295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APT56_RS06300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_RS06305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_RS06325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_RS06330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_RS06335	COG1309	transcriptional regulator
APT56_RS06340	COG0583	DNA-binding transcription factor activity
APT56_RS06360	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT56_RS06385	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_RS06390	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT56_RS06395	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT56_RS06400	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT56_RS06405	COG0649	NAD binding
APT56_RS06410	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APT56_RS06420	COG1034	ATP synthesis coupled electron transport
APT56_RS06425	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APT56_RS06430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APT56_RS06440	COG0713	ATP synthesis coupled electron transport
APT56_RS06455	COG1007	ATP synthesis coupled electron transport
APT56_RS06465	COG4774	siderophore transport
APT56_RS06470	COG0560	Phosphoserine phosphatase
APT56_RS06475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APT56_RS06480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APT56_RS06485	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APT56_RS06495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT56_RS06500	COG0450	alkyl hydroperoxide reductase
APT56_RS06515	COG1214	PFAM Peptidase M22, glycoprotease
APT56_RS06520	COG1573	uracil-dna glycosylase
APT56_RS06525	COG0477	Major facilitator Superfamily
APT56_RS06530	COG1196	nuclear chromosome segregation
APT56_RS06540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APT56_RS06545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT56_RS06555	COG2917	probably involved in intracellular septation
APT56_RS06560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT56_RS06565	COG1122	ATPase activity
APT56_RS06570	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APT56_RS06575	COG1268	BioY protein
APT56_RS06610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APT56_RS06645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APT56_RS06650	COG2878	Part of a membrane complex involved in electron transport
APT56_RS06665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APT56_RS06670	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
APT56_RS06675	COG0251	oxidation-reduction process
APT56_RS06685	COG3228	Belongs to the MtfA family
APT56_RS06690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APT56_RS06700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT56_RS06710	COG0159	tryptophan synthase activity
APT56_RS06715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APT56_RS06720	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APT56_RS06725	COG1530	ribonuclease E activity
APT56_RS06730	COG0564	pseudouridine synthase activity
APT56_RS06735	COG0546	phosphoglycolate phosphatase activity
APT56_RS06740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APT56_RS06745	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
APT56_RS06760	COG0424	maF-like protein
APT56_RS06770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APT56_RS06780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APT56_RS06785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APT56_RS06795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT56_RS06800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT56_RS06825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT56_RS06835	COG0681	Belongs to the peptidase S26 family
APT56_RS06840	COG0571	ribonuclease III activity
APT56_RS06845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APT56_RS06850	COG1381	Involved in DNA repair and RecF pathway recombination
APT56_RS06860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APT56_RS06880	COG0667	Aldo Keto reductase
APT56_RS06900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APT56_RS06925	COG0583	DNA-binding transcription factor activity
APT56_RS06935	COG0791	NLP P60 protein
APT56_RS06945	COG3193	protein, possibly involved in utilization of glycolate and propanediol
APT56_RS06955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APT56_RS06960	COG0697	spore germination
APT56_RS06965	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
APT56_RS07005	COG2153	protein acetylation
APT56_RS07015	COG1446	asparaginase
APT56_RS07020	COG4172	Belongs to the ABC transporter superfamily
APT56_RS07025	COG0747	negative chemotaxis
APT56_RS07035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS07060	COG0504	CTP synthase activity
APT56_RS07070	COG0148	phosphopyruvate hydratase activity
APT56_RS07085	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APT56_RS07095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APT56_RS07130	COG1981	membrane
APT56_RS07150	COG0039	L-malate dehydrogenase activity
APT56_RS07155	COG2188	Transcriptional regulator
APT56_RS07160	COG2009	succinate dehydrogenase
APT56_RS07165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APT56_RS07170	COG1053	succinate dehydrogenase
APT56_RS07175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APT56_RS07180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APT56_RS07185	COG0372	Belongs to the citrate synthase family
APT56_RS07200	COG0281	malic enzyme
APT56_RS07200	COG0280	phosphate acetyltransferase
APT56_RS07210	COG1297	OPT oligopeptide transporter protein
APT56_RS07215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT56_RS07230	COG2515	1-aminocyclopropane-1-carboxylate deaminase
APT56_RS07235	COG1522	sequence-specific DNA binding
APT56_RS07240	COG0567	Dehydrogenase, E1 component
APT56_RS07245	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT56_RS07250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT56_RS07255	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APT56_RS07260	COG1595	DNA-templated transcription, initiation
APT56_RS07265	COG3712	iron ion homeostasis
APT56_RS07270	COG4774	siderophore transport
APT56_RS07305	COG2183	response to ionizing radiation
APT56_RS07310	COG1199	ATP-dependent helicase activity
APT56_RS07320	COG0564	pseudouridine synthase activity
APT56_RS07325	COG1496	oxidoreductase activity
APT56_RS07330	COG3243	poly(R)-hydroxyalkanoic acid synthase
APT56_RS07335	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS07340	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
APT56_RS07365	COG2831	hemolysin activation secretion protein
APT56_RS07380	COG3210	domain, Protein
APT56_RS07390	COG2823	Periplasmic or secreted lipoprotein
APT56_RS07395	COG3237	CsbD-like
APT56_RS07400	COG0189	ligase activity
APT56_RS07400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT56_RS07405	COG0189	ligase activity
APT56_RS07405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APT56_RS07410	COG1132	(ABC) transporter
APT56_RS07425	COG2833	Protein of unknown function (DUF455)
APT56_RS07430	COG2258	MOSC domain
APT56_RS07435	COG2951	lytic endotransglycosylase activity
APT56_RS07450	COG1960	acyl-CoA dehydrogenase activity
APT56_RS07460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APT56_RS07470	COG1696	Membrane protein involved in D-alanine export
APT56_RS07490	COG1215	transferase activity, transferring glycosyl groups
APT56_RS07500	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APT56_RS07525	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APT56_RS07540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
APT56_RS07550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APT56_RS07560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APT56_RS07565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APT56_RS07585	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APT56_RS07590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APT56_RS07595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT56_RS07625	COG2951	lytic endotransglycosylase activity
APT56_RS07630	COG0123	including yeast histone deacetylase and acetoin utilization protein
APT56_RS07655	COG2985	domain, Protein
APT56_RS07660	COG1960	acyl-CoA dehydrogenase activity
APT56_RS07665	COG0450	alkyl hydroperoxide reductase
APT56_RS07675	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APT56_RS07680	COG4208	sulfate ABC transporter
APT56_RS07690	COG0175	sulfate reduction
APT56_RS07720	COG0335	large ribosomal subunit rRNA binding
APT56_RS07730	COG1162	GTPase activity
APT56_RS07735	COG0501	Belongs to the peptidase M48B family
APT56_RS07740	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
APT56_RS07745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APT56_RS07750	COG3327	negative regulation of DNA-templated transcription, initiation
APT56_RS07755	COG3396	Phenylacetate-CoA oxygenase
APT56_RS07760	COG3460	Phenylacetate-CoA oxygenase
APT56_RS07765	COG3396	Phenylacetate-CoA oxygenase
APT56_RS07770	COG2151	metal-sulfur cluster biosynthetic enzyme
APT56_RS07775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT56_RS07780	COG1012	belongs to the aldehyde dehydrogenase family
APT56_RS07785	COG1024	Enoyl-CoA hydratase
APT56_RS07790	COG2050	protein possibly involved in aromatic compounds catabolism
APT56_RS07800	COG0534	Mate efflux family protein
APT56_RS07815	COG3483	tryptophan 2,3-dioxygenase activity
APT56_RS07820	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
APT56_RS07825	COG2003	Belongs to the UPF0758 family
APT56_RS07835	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APT56_RS07840	COG0625	glutathione transferase activity
APT56_RS07845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APT56_RS07870	COG0523	cobalamin synthesis protein
APT56_RS07875	COG0523	cobalamin synthesis protein
APT56_RS07880	COG0583	DNA-binding transcription factor activity
APT56_RS07890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
APT56_RS07895	COG1187	pseudouridine synthase activity
APT56_RS07900	COG0779	Required for maturation of 30S ribosomal subunits
APT56_RS07905	COG2251	uridine kinase activity
APT56_RS07905	COG0195	Participates in both transcription termination and antitermination
APT56_RS07910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APT56_RS07915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APT56_RS07920	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APT56_RS07925	COG1217	gtp-binding protein TYPA
APT56_RS07945	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS07950	COG1473	amidohydrolase
APT56_RS07955	COG1611	Belongs to the LOG family
APT56_RS07960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APT56_RS07960	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APT56_RS07970	COG0412	Dienelactone hydrolase
APT56_RS07975	COG1283	sodium-dependent phosphate transmembrane transporter activity
APT56_RS07980	COG1760	l-serine dehydratase
APT56_RS07985	COG0501	Belongs to the peptidase M48B family
APT56_RS08005	COG0583	DNA-binding transcription factor activity
APT56_RS08010	COG3842	ATPase activity
APT56_RS08020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT56_RS08025	COG1840	ABC-type Fe3 transport system, periplasmic component
APT56_RS08045	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS08055	COG1722	exodeoxyribonuclease VII activity
APT56_RS08060	COG0142	geranyltranstransferase activity
APT56_RS08070	COG1469	GTP cyclohydrolase I activity
APT56_RS08075	COG3739	integral membrane protein
APT56_RS08080	COG0360	Binds together with S18 to 16S ribosomal RNA
APT56_RS08085	COG2965	DNA replication, synthesis of RNA primer
APT56_RS08090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APT56_RS08095	COG0359	binds to the 23S rRNA
APT56_RS08105	COG0305	Participates in initiation and elongation during chromosome replication
APT56_RS08115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APT56_RS08150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_RS08170	COG0493	'glutamate synthase
APT56_RS08200	COG0540	Belongs to the ATCase OTCase family
APT56_RS08235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
APT56_RS08240	COG2137	regulation of response to DNA damage stimulus
APT56_RS08255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APT56_RS08265	COG0045	succinate-CoA ligase (ADP-forming) activity
APT56_RS08270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APT56_RS08275	COG0861	Integral membrane protein TerC family
APT56_RS08280	COG0861	Integral membrane protein TerC family
APT56_RS08285	COG0181	hydroxymethylbilane synthase activity
APT56_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS08345	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_RS08365	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
APT56_RS08370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APT56_RS08380	COG0436	Aminotransferase
APT56_RS08400	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APT56_RS08405	COG0308	aminopeptidase N
APT56_RS08420	COG0312	modulator of DNA gyrase
APT56_RS08425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APT56_RS08430	COG0277	FAD linked oxidase domain protein
APT56_RS08435	COG0277	FAD linked oxidase domain protein
APT56_RS08440	COG0277	FAD linked oxidase domain protein
APT56_RS08445	COG0247	lactate metabolic process
APT56_RS08475	COG0583	DNA-binding transcription factor activity
APT56_RS08480	COG0482	sulfurtransferase activity
APT56_RS08485	COG0730	response to heat
APT56_RS08490	COG0625	glutathione transferase activity
APT56_RS08500	COG3909	cytochrome
APT56_RS08530	COG0628	permease
APT56_RS08540	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
APT56_RS08660	COG0697	spore germination
APT56_RS08695	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
APT56_RS08705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT56_RS08710	COG0069	glutamate synthase activity
APT56_RS08715	COG2391	methyltransferase activity
APT56_RS08720	COG0679	Auxin Efflux Carrier
APT56_RS08750	COG0557	exoribonuclease II activity
APT56_RS08755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT56_RS08765	COG3128	pkhd-type hydroxylase
APT56_RS08770	COG0776	regulation of translation
APT56_RS08800	COG0642	Histidine kinase
APT56_RS08805	COG3158	transport of potassium into the cell
APT56_RS08820	COG0137	argininosuccinate synthase activity
APT56_RS08825	COG1538	Outer membrane efflux protein
APT56_RS08835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_RS08845	COG5002	protein histidine kinase activity
APT56_RS08850	COG0583	DNA-binding transcription factor activity
APT56_RS08855	COG3618	amidohydrolase
APT56_RS08875	COG0596	Alpha beta hydrolase
APT56_RS08875	COG2945	thiolester hydrolase activity
APT56_RS08880	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APT56_RS08885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APT56_RS08910	COG0601	transmembrane transport
APT56_RS08915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS08935	COG4608	Belongs to the ABC transporter superfamily
APT56_RS08940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APT56_RS08940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APT56_RS08950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_RS08955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
APT56_RS08965	COG3642	lipopolysaccharide core region biosynthetic process
APT56_RS08975	COG3842	ATPase activity
APT56_RS08980	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT56_RS08985	COG1177	transmembrane transport
APT56_RS09015	COG1960	acyl-CoA dehydrogenase activity
APT56_RS09025	COG0704	Plays a role in the regulation of phosphate uptake
APT56_RS09035	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
APT56_RS09040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APT56_RS09040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APT56_RS09045	COG1643	Atp-dependent helicase
APT56_RS09050	COG0395	ABC-type sugar transport system, permease component
APT56_RS09055	COG1116	anion transmembrane transporter activity
APT56_RS09070	COG0438	transferase activity, transferring glycosyl groups
APT56_RS09075	COG0726	polysaccharide deacetylase
APT56_RS09090	COG0726	polysaccharide deacetylase
APT56_RS09115	COG1132	(ABC) transporter
APT56_RS09120	COG0475	glutathione-regulated potassium exporter activity
APT56_RS09120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APT56_RS09135	COG2203	Gaf domain
APT56_RS09135	COG5001	Diguanylate cyclase
APT56_RS09135	COG3706	GGDEF domain
APT56_RS09135	COG4251	negative regulation of phosphorylation
APT56_RS09145	COG1530	ribonuclease E activity
APT56_RS09175	COG2204	response regulator
APT56_RS09180	COG4191	Histidine kinase
APT56_RS09185	COG1301	dicarboxylic acid transport
APT56_RS09195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
APT56_RS09200	COG0799	negative regulation of ribosome biogenesis
APT56_RS09205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APT56_RS09215	COG0151	Belongs to the GarS family
APT56_RS09220	COG0217	transcriptional regulatory protein
APT56_RS09225	COG0433	COG0433 Predicted ATPase
APT56_RS09230	COG0473	3-isopropylmalate dehydrogenase activity
APT56_RS09240	COG2814	Major facilitator Superfamily
APT56_RS09245	COG1566	PFAM secretion protein HlyD family protein
APT56_RS09255	COG1846	Transcriptional regulator
APT56_RS09285	COG3391	amine dehydrogenase activity
APT56_RS09295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APT56_RS09315	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APT56_RS09320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
APT56_RS09335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APT56_RS09360	COG1309	transcriptional regulator
APT56_RS09365	COG2311	Membrane
APT56_RS09370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APT56_RS09395	COG0662	Cupin 2, conserved barrel domain protein
APT56_RS09400	COG5285	phytanoyl-CoA dioxygenase
APT56_RS09405	COG3217	Mosc domain protein beta barrel domain protein
APT56_RS09405	COG0633	Ferredoxin
APT56_RS09410	COG2076	Multidrug Resistance protein
APT56_RS09415	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APT56_RS09425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_RS09440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APT56_RS09445	COG0425	Belongs to the sulfur carrier protein TusA family
APT56_RS09455	COG0228	four-way junction DNA binding
APT56_RS09465	COG0336	Belongs to the RNA methyltransferase TrmD family
APT56_RS09470	COG1396	sequence-specific DNA binding
APT56_RS09475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS09480	COG0765	amino acid transport
APT56_RS09485	COG1126	abc transporter atp-binding protein
APT56_RS09490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_RS09495	COG0525	valine-tRNA ligase activity
APT56_RS09500	COG0105	UTP biosynthetic process
APT56_RS09505	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APT56_RS09525	COG2976	Protein conserved in bacteria
APT56_RS09530	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT56_RS09535	COG1160	GTP binding
APT56_RS09540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APT56_RS09545	COG1923	regulation of RNA biosynthetic process
APT56_RS09550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APT56_RS09555	COG0330	HflC and HflK could
APT56_RS09560	COG0330	HflC and HflK could
APT56_RS09565	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APT56_RS09570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APT56_RS09575	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
APT56_RS09580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APT56_RS09605	COG0438	transferase activity, transferring glycosyl groups
APT56_RS09620	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
APT56_RS09620	COG2755	lipolytic protein G-D-S-L family
APT56_RS09650	COG4964	Belongs to the GSP D family
APT56_RS09680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APT56_RS09690	COG1295	ribonuclease BN
APT56_RS09700	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APT56_RS09725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APT56_RS09760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_RS09765	COG2274	protein secretion by the type I secretion system
APT56_RS09775	COG1538	Outer membrane efflux protein
APT56_RS09795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APT56_RS09805	COG0101	tRNA pseudouridine synthase activity
APT56_RS09810	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
APT56_RS09815	COG0135	phosphoribosylanthranilate isomerase activity
APT56_RS09860	COG0657	acetylesterase activity
APT56_RS09860	COG2755	lipolytic protein G-D-S-L family
APT56_RS09865	COG0129	dihydroxy-acid dehydratase activity
APT56_RS09870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_RS09875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APT56_RS09880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APT56_RS09885	COG1609	Transcriptional regulator
APT56_RS09910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS09915	COG0601	transmembrane transport
APT56_RS09925	COG1012	belongs to the aldehyde dehydrogenase family
APT56_RS09955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APT56_RS09960	COG2197	response regulator
APT56_RS09970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APT56_RS09975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APT56_RS09990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APT56_RS09995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APT56_RS10000	COG0004	ammonium transporteR
APT56_RS10005	COG0347	Belongs to the P(II) protein family
APT56_RS10015	COG2960	long-chain fatty acid transporting porin activity
APT56_RS10025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APT56_RS10030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APT56_RS10035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APT56_RS10040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT56_RS10040	COG0072	phenylalanine-tRNA ligase activity
APT56_RS10065	COG1475	DNA binding
APT56_RS10075	COG3723	Recombinational DNA repair protein, rece pathway
APT56_RS10080	COG5377	YqaJ viral recombinase family
APT56_RS10125	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
APT56_RS10145	COG5410	chromosome segregation
APT56_RS10155	COG2369	cell adhesion
APT56_RS10325	COG0384	phenazine biosynthesis protein PhzF
APT56_RS10375	COG1522	sequence-specific DNA binding
APT56_RS10405	COG0583	DNA-binding transcription factor activity
APT56_RS10410	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS10435	COG1116	anion transmembrane transporter activity
APT56_RS10465	COG5265	(ABC) transporter
APT56_RS10470	COG0656	L-ascorbic acid biosynthetic process
APT56_RS10485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APT56_RS10500	COG2223	nitrite transmembrane transporter activity
APT56_RS10510	COG1215	transferase activity, transferring glycosyl groups
APT56_RS10515	COG1649	PFAM Uncharacterised BCR, COG1649
APT56_RS10515	COG0726	polysaccharide deacetylase
APT56_RS10520	COG0457	Tetratricopeptide repeat
APT56_RS10550	COG1610	YqeY-like protein
APT56_RS10560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT56_RS10565	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS10575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT56_RS10615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APT56_RS10625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT56_RS10630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APT56_RS10655	COG1959	2 iron, 2 sulfur cluster binding
APT56_RS10660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_RS10665	COG0697	spore germination
APT56_RS10670	COG0506	proline dehydrogenase activity
APT56_RS10690	COG0583	DNA-binding transcription factor activity
APT56_RS10695	COG2814	Major facilitator Superfamily
APT56_RS10700	COG0583	DNA-binding transcription factor activity
APT56_RS10705	COG0583	DNA-binding transcription factor activity
APT56_RS10710	COG0625	glutathione transferase activity
APT56_RS10725	COG2814	Major facilitator Superfamily
APT56_RS10730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APT56_RS10750	COG1960	acyl-CoA dehydrogenase activity
APT56_RS10755	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_RS10775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APT56_RS10780	COG1280	lysine exporter protein (LysE YggA)
APT56_RS10795	COG1280	lysine exporter protein (LysE YggA)
APT56_RS10810	COG0697	spore germination
APT56_RS10815	COG0697	spore germination
APT56_RS10830	COG0534	Mate efflux family protein
APT56_RS10835	COG1024	Enoyl-CoA hydratase
APT56_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS10850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APT56_RS10855	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
APT56_RS10865	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS10900	COG2207	Transcriptional regulator
APT56_RS10905	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS10910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APT56_RS10915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APT56_RS10935	COG1063	alcohol dehydrogenase
APT56_RS10945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT56_RS10955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APT56_RS10960	COG4172	Belongs to the ABC transporter superfamily
APT56_RS10985	COG0583	DNA-binding transcription factor activity
APT56_RS11010	COG3088	subunit of a heme lyase
APT56_RS11015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_RS11025	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
APT56_RS11040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APT56_RS11045	COG4133	protoheme IX ABC transporter activity
APT56_RS11050	COG3005	denitrification pathway
APT56_RS11060	COG3381	protein complex oligomerization
APT56_RS11080	COG3246	L-lysine catabolic process to acetate
APT56_RS11085	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_RS11090	COG0583	DNA-binding transcription factor activity
APT56_RS11100	COG0129	dihydroxy-acid dehydratase activity
APT56_RS11105	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS11110	COG5001	Diguanylate cyclase
APT56_RS11115	COG1024	Enoyl-CoA hydratase
APT56_RS11155	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
APT56_RS11160	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS11165	COG0583	DNA-binding transcription factor activity
APT56_RS11170	COG2610	gluconate transmembrane transporter activity
APT56_RS11210	COG0235	Class ii aldolase
APT56_RS11215	COG0477	Major facilitator Superfamily
APT56_RS11230	COG2188	Transcriptional regulator
APT56_RS11235	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_RS11280	COG5265	(ABC) transporter
APT56_RS11290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_RS11310	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS11325	COG2059	Chromate
APT56_RS11345	COG1132	(ABC) transporter
APT56_RS11350	COG0583	DNA-binding transcription factor activity
APT56_RS11365	COG0583	DNA-binding transcription factor activity
APT56_RS11380	COG2814	Major facilitator Superfamily
APT56_RS11405	COG2814	Major facilitator Superfamily
APT56_RS11410	COG0154	amidase activity
APT56_RS11460	COG2070	2-Nitropropane dioxygenase
APT56_RS11490	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS11505	COG0307	riboflavin synthase, alpha
APT56_RS11515	COG2271	Major facilitator Superfamily
APT56_RS11525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APT56_RS11535	COG0789	Transcriptional regulator
APT56_RS11560	COG4774	siderophore transport
APT56_RS11570	COG0022	dehydrogenase e1 component
APT56_RS11590	COG0165	Argininosuccinate lyase
APT56_RS11595	COG0668	transmembrane transport
APT56_RS11610	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
APT56_RS11680	COG2165	general secretion pathway protein
APT56_RS11715	COG0583	DNA-binding transcription factor activity
APT56_RS11725	COG0747	negative chemotaxis
APT56_RS11730	COG0601	transmembrane transport
APT56_RS11735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS11740	COG4172	Belongs to the ABC transporter superfamily
APT56_RS11745	COG4681	YaeQ
APT56_RS11765	COG0477	Major facilitator Superfamily
APT56_RS11770	COG3161	chorismate lyase activity
APT56_RS11775	COG1187	pseudouridine synthase activity
APT56_RS11780	COG0583	DNA-binding transcription factor activity
APT56_RS11800	COG2261	transglycosylase associated protein
APT56_RS11805	COG1999	signal sequence binding
APT56_RS11815	COG0339	signal peptide processing
APT56_RS11820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APT56_RS11825	COG4566	intracellular signal transduction
APT56_RS11840	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT56_RS11845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT56_RS11875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APT56_RS11875	COG4797	methyltransferase
APT56_RS11880	COG1191	sigma factor activity
APT56_RS11905	COG0745	RESPONSE REGULATOR receiver
APT56_RS11915	COG0835	chemotaxis
APT56_RS11920	COG0840	transmembrane signaling receptor activity
APT56_RS11925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APT56_RS11930	COG2201	protein-glutamate methylesterase activity
APT56_RS11935	COG0745	RESPONSE REGULATOR receiver
APT56_RS11940	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
APT56_RS11945	COG3290	protein histidine kinase activity
APT56_RS11945	COG0840	transmembrane signaling receptor activity
APT56_RS11970	COG2747	anti-sigma28 factor FlgM
APT56_RS11985	COG1558	bacterial-type flagellum-dependent cell motility
APT56_RS12000	COG4787	bacterial-type flagellum-dependent cell motility
APT56_RS12035	COG0840	transmembrane signaling receptor activity
APT56_RS12040	COG0840	transmembrane signaling receptor activity
APT56_RS12050	COG0840	transmembrane signaling receptor activity
APT56_RS12055	COG0840	transmembrane signaling receptor activity
APT56_RS12080	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APT56_RS12090	COG1580	Controls the rotational direction of flagella during chemotaxis
APT56_RS12115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APT56_RS12120	COG1766	The M ring may be actively involved in energy transduction
APT56_RS12125	COG1677	Flagellar hook-basal body complex protein FliE
APT56_RS12135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APT56_RS12155	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APT56_RS12175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_RS12180	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS12190	COG0285	dihydrofolate synthase activity
APT56_RS12200	COG1286	toxin biosynthetic process
APT56_RS12210	COG1451	nucleotide metabolic process
APT56_RS12220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APT56_RS12230	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
APT56_RS12235	COG0024	Methionine aminopeptidase
APT56_RS12240	COG0052	Belongs to the universal ribosomal protein uS2 family
APT56_RS12245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APT56_RS12250	COG0528	UMP kinase activity
APT56_RS12255	COG0233	cytoplasmic translational termination
APT56_RS12260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APT56_RS12270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APT56_RS12275	COG0750	zinc metalloprotease
APT56_RS12280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APT56_RS12285	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
APT56_RS12290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT56_RS12295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APT56_RS12310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APT56_RS12315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APT56_RS12345	COG4774	siderophore transport
APT56_RS12360	COG2169	Transcriptional regulator
APT56_RS12360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT56_RS12365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APT56_RS12365	COG0519	Catalyzes the synthesis of GMP from XMP
APT56_RS12385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APT56_RS12390	COG2867	negative regulation of translational initiation
APT56_RS12395	COG2914	Belongs to the UPF0125 (RnfH) family
APT56_RS12405	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_RS12405	COG1024	Enoyl-CoA hydratase
APT56_RS12430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APT56_RS12435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APT56_RS12440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APT56_RS12445	COG0084	hydrolase, TatD family'
APT56_RS12460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS12465	COG0765	amino acid transport
APT56_RS12470	COG1126	abc transporter atp-binding protein
APT56_RS12475	COG0010	Belongs to the arginase family
APT56_RS12485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APT56_RS12495	COG0095	Lipoate-protein ligase
APT56_RS12510	COG0625	glutathione transferase activity
APT56_RS12520	COG1522	sequence-specific DNA binding
APT56_RS12525	COG0386	Belongs to the glutathione peroxidase family
APT56_RS12530	COG2814	Major facilitator Superfamily
APT56_RS12560	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APT56_RS12570	COG0840	transmembrane signaling receptor activity
APT56_RS12580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_RS12600	COG0513	Belongs to the DEAD box helicase family
APT56_RS12605	COG1414	Transcriptional regulator
APT56_RS12620	COG0747	negative chemotaxis
APT56_RS12625	COG0601	transmembrane transport
APT56_RS12630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS12640	COG1228	amidohydrolase
APT56_RS12675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_RS12680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
APT56_RS12685	COG4521	taurine ABC transporter
APT56_RS12690	COG0583	DNA-binding transcription factor activity
APT56_RS12695	COG0697	spore germination
APT56_RS12715	COG1966	Carbon starvation protein
APT56_RS12720	COG2879	small protein
APT56_RS12725	COG0697	spore germination
APT56_RS12730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_RS12750	COG0783	Belongs to the Dps family
APT56_RS12765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT56_RS12770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APT56_RS12780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APT56_RS12785	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
APT56_RS12790	COG0745	RESPONSE REGULATOR receiver
APT56_RS12795	COG5002	protein histidine kinase activity
APT56_RS12800	COG2070	2-Nitropropane dioxygenase
APT56_RS12820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_RS12850	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS12860	COG0583	DNA-binding transcription factor activity
APT56_RS12870	COG0583	DNA-binding transcription factor activity
APT56_RS12895	COG2223	nitrite transmembrane transporter activity
APT56_RS12900	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APT56_RS12905	COG1140	nitrate reductase beta subunit
APT56_RS12910	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APT56_RS12915	COG2181	nitrate reductase activity
APT56_RS12920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT56_RS12925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APT56_RS12930	COG0288	reversible hydration of carbon dioxide
APT56_RS12935	COG1763	Mo-molybdopterin cofactor biosynthetic process
APT56_RS12940	COG3850	Histidine kinase
APT56_RS12945	COG2197	response regulator
APT56_RS12950	COG0826	peptidase U32
APT56_RS12955	COG0826	peptidase U32
APT56_RS12960	COG3154	lipid carrier protein
APT56_RS12965	COG4597	amino acid ABC transporter
APT56_RS12970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS13005	COG1116	anion transmembrane transporter activity
APT56_RS13010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_RS13015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_RS13040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APT56_RS13055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_RS13060	COG1802	Transcriptional regulator
APT56_RS13105	COG0251	oxidation-reduction process
APT56_RS13130	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
APT56_RS13155	COG0277	FAD linked oxidase domain protein
APT56_RS13160	COG0436	Aminotransferase
APT56_RS13165	COG0765	amino acid transport
APT56_RS13175	COG1126	abc transporter atp-binding protein
APT56_RS13195	COG0583	DNA-binding transcription factor activity
APT56_RS13260	COG4566	intracellular signal transduction
APT56_RS13265	COG4191	Histidine kinase
APT56_RS13280	COG0583	DNA-binding transcription factor activity
APT56_RS13285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APT56_RS13315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APT56_RS13325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_RS13330	COG2070	2-Nitropropane dioxygenase
APT56_RS13335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS13340	COG0765	amino acid transport
APT56_RS13345	COG1126	abc transporter atp-binding protein
APT56_RS13350	COG1120	ATPase activity
APT56_RS13355	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_RS13360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_RS13365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APT56_RS13405	COG3486	L-lysine 6-monooxygenase (NADPH) activity
APT56_RS13410	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APT56_RS13415	COG0390	transport system, permease component
APT56_RS13420	COG0586	Pfam SNARE associated Golgi protein
APT56_RS13435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APT56_RS13440	COG1120	ATPase activity
APT56_RS13445	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
APT56_RS13450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_RS13460	COG0745	RESPONSE REGULATOR receiver
APT56_RS13475	COG1126	abc transporter atp-binding protein
APT56_RS13480	COG0765	amino acid transport
APT56_RS13485	COG4597	amino acid ABC transporter
APT56_RS13490	COG0436	Aminotransferase
APT56_RS13495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS13500	COG2188	Transcriptional regulator
APT56_RS13520	COG2721	sulfolactate sulfo-lyase activity
APT56_RS13525	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS13545	COG1276	copper resistance
APT56_RS13555	COG0519	Catalyzes the synthesis of GMP from XMP
APT56_RS13555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APT56_RS13560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT56_RS13570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_RS13575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_RS13580	COG2358	TRAP transporter, solute receptor (TAXI family
APT56_RS13590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APT56_RS13595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT56_RS13600	COG4208	sulfate ABC transporter
APT56_RS13605	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APT56_RS13610	COG4150	thiosulfate binding
APT56_RS13620	COG4771	TonB-dependent receptor
APT56_RS13630	COG1126	abc transporter atp-binding protein
APT56_RS13650	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
APT56_RS13660	COG1640	4-alpha-glucanotransferase
APT56_RS13665	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APT56_RS13675	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APT56_RS13680	COG0366	Alpha amylase catalytic
APT56_RS13685	COG0366	Alpha amylase catalytic
APT56_RS13690	COG0297	glycogen (starch) synthase activity
APT56_RS13695	COG0392	lysyltransferase activity
APT56_RS13700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT56_RS13705	COG3568	Endonuclease Exonuclease Phosphatase
APT56_RS13710	COG0387	Pfam Sodium calcium exchanger
APT56_RS13720	COG3685	Protein conserved in bacteria
APT56_RS13730	COG0166	Belongs to the GPI family
APT56_RS13740	COG0668	transmembrane transport
APT56_RS13760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APT56_RS13770	COG0589	response to stress
APT56_RS13780	COG0589	response to stress
APT56_RS13790	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
APT56_RS13795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APT56_RS13800	COG0617	tRNA 3'-terminal CCA addition
APT56_RS13800	COG0517	IMP dehydrogenase activity
APT56_RS13800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APT56_RS13820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT56_RS13835	COG0589	response to stress
APT56_RS13840	COG1914	H( )-stimulated, divalent metal cation uptake system
APT56_RS13865	COG0071	Belongs to the small heat shock protein (HSP20) family
APT56_RS13890	COG1280	lysine exporter protein (LysE YggA)
APT56_RS13910	COG0579	oxidoreductase
APT56_RS13920	COG0477	Major facilitator Superfamily
APT56_RS13935	COG0625	glutathione transferase activity
APT56_RS13965	COG3971	2-oxopent-4-enoate hydratase activity
APT56_RS13990	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
APT56_RS14005	COG0179	Fumarylacetoacetate (FAA) hydrolase
APT56_RS14025	COG0251	oxidation-reduction process
APT56_RS14035	COG0747	negative chemotaxis
APT56_RS14040	COG0601	transmembrane transport
APT56_RS14050	COG0444	Belongs to the ABC transporter superfamily
APT56_RS14055	COG4608	Belongs to the ABC transporter superfamily
APT56_RS14060	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APT56_RS14070	COG0531	amino acid
APT56_RS14095	COG0628	permease
APT56_RS14155	COG3706	GGDEF domain
APT56_RS14165	COG0789	Transcriptional regulator
APT56_RS14170	COG3706	GGDEF domain
APT56_RS14225	COG2205	protein histidine kinase activity
APT56_RS14235	COG1253	flavin adenine dinucleotide binding
APT56_RS14285	COG5001	Diguanylate cyclase
APT56_RS14285	COG3300	MHYT domain
APT56_RS14290	COG1289	transmembrane transporter activity
APT56_RS14300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT56_RS14310	COG0693	protein deglycase activity
APT56_RS14330	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS14365	COG2204	response regulator
APT56_RS14370	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APT56_RS14395	COG2814	Major facilitator Superfamily
APT56_RS14410	COG3300	MHYT domain
APT56_RS14410	COG5001	Diguanylate cyclase
APT56_RS14415	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APT56_RS14420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_RS14445	COG0488	(ABC) transporter
APT56_RS14455	COG0688	phosphatidylethanolamine metabolic process
APT56_RS14485	COG1408	metallophosphoesterase
APT56_RS14495	COG2814	Major facilitator Superfamily
APT56_RS14505	COG1464	Belongs to the NlpA lipoprotein family
APT56_RS14510	COG0010	Belongs to the arginase family
APT56_RS14515	COG1414	Transcriptional regulator
APT56_RS14530	COG2363	Small membrane protein
APT56_RS14535	COG0697	spore germination
APT56_RS14545	COG2133	pyrroloquinoline quinone binding
APT56_RS14550	COG0625	glutathione transferase activity
APT56_RS14555	COG0583	DNA-binding transcription factor activity
APT56_RS14565	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APT56_RS14595	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_RS14605	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APT56_RS14615	COG1653	transport
APT56_RS14620	COG1175	transmembrane transport
APT56_RS14625	COG0395	ABC-type sugar transport system, permease component
APT56_RS14630	COG3842	ATPase activity
APT56_RS14645	COG2205	protein histidine kinase activity
APT56_RS14650	COG0745	RESPONSE REGULATOR receiver
APT56_RS14670	COG4783	chaperone-mediated protein folding
APT56_RS14670	COG1560	Kdo2-lipid A biosynthetic process
APT56_RS14695	COG0438	transferase activity, transferring glycosyl groups
APT56_RS14700	COG0457	Tetratricopeptide repeat
APT56_RS14710	COG0783	Belongs to the Dps family
APT56_RS14720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APT56_RS14740	COG0583	DNA-binding transcription factor activity
APT56_RS14755	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS14765	COG1840	ABC-type Fe3 transport system, periplasmic component
APT56_RS14770	COG4149	molybdate abc transporter
APT56_RS14775	COG3842	ATPase activity
APT56_RS14785	COG1690	Belongs to the RtcB family
APT56_RS14790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APT56_RS14795	COG1741	Belongs to the pirin family
APT56_RS14800	COG1741	Belongs to the pirin family
APT56_RS14805	COG0583	DNA-binding transcription factor activity
APT56_RS14810	COG2204	response regulator
APT56_RS14820	COG0174	glutamine synthetase
APT56_RS14825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APT56_RS14830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APT56_RS14855	COG1960	acyl-CoA dehydrogenase activity
APT56_RS14865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APT56_RS14870	COG1561	YicC-like family, N-terminal region
APT56_RS14875	COG0833	amino acid
APT56_RS14880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APT56_RS14895	COG0791	NLP P60 protein
APT56_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS14910	COG2863	cytochrome
APT56_RS14915	COG3258	Cytochrome c
APT56_RS14920	COG0194	GDP metabolic process
APT56_RS14925	COG1758	RNA polymerase activity
APT56_RS14930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APT56_RS14935	COG1126	abc transporter atp-binding protein
APT56_RS14940	COG0765	amino acid transport
APT56_RS14945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS14965	COG2816	NAD+ diphosphatase activity
APT56_RS14985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_RS15015	COG4336	lyase activity
APT56_RS15020	COG0583	DNA-binding transcription factor activity
APT56_RS15035	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APT56_RS15050	COG0583	DNA-binding transcription factor activity
APT56_RS15060	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APT56_RS15065	COG0560	Phosphoserine phosphatase
APT56_RS15070	COG0583	DNA-binding transcription factor activity
APT56_RS15075	COG3842	ATPase activity
APT56_RS15080	COG1178	ABC-type Fe3 transport system permease component
APT56_RS15090	COG4181	ATPase activity
APT56_RS15100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT56_RS15110	COG0584	glycerophosphoryl diester phosphodiesterase
APT56_RS15115	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APT56_RS15125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APT56_RS15125	COG0678	peroxiredoxin activity
APT56_RS15140	COG0789	Transcriptional regulator
APT56_RS15145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APT56_RS15170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APT56_RS15180	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APT56_RS15185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APT56_RS15190	COG2252	PERMEase
APT56_RS15200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT56_RS15205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_RS15240	COG0488	(ABC) transporter
APT56_RS15245	COG1619	proteins homologs of microcin C7 resistance protein MccF
APT56_RS15250	COG0590	tRNA wobble adenosine to inosine editing
APT56_RS15265	COG1320	monovalent cation:proton antiporter activity
APT56_RS15270	COG2212	antiporter activity
APT56_RS15275	COG1863	multisubunit Na H antiporter MnhE subunit
APT56_RS15280	COG0651	ATP synthesis coupled electron transport
APT56_RS15285	COG1006	Multisubunit Na H antiporter MnhC subunit
APT56_RS15290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APT56_RS15290	COG2111	Na H antiporter
APT56_RS15315	COG0420	3'-5' exonuclease activity
APT56_RS15320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_RS15355	COG1960	acyl-CoA dehydrogenase activity
APT56_RS15360	COG1959	2 iron, 2 sulfur cluster binding
APT56_RS15365	COG3634	alkyl hydroperoxide reductase activity
APT56_RS15390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_RS15425	COG0395	ABC-type sugar transport system, permease component
APT56_RS15435	COG3842	ATPase activity
APT56_RS15440	COG3842	ATPase activity
APT56_RS15465	COG2130	NADP-dependent
APT56_RS15480	COG1131	(ABC) transporter
APT56_RS15485	COG0842	Transport permease protein
APT56_RS15500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APT56_RS15530	COG1902	pentaerythritol trinitrate reductase activity
APT56_RS15545	COG0602	queuosine metabolic process
APT56_RS15550	COG0720	synthase
APT56_RS15560	COG1289	transmembrane transporter activity
APT56_RS15570	COG1566	PFAM secretion protein HlyD family protein
APT56_RS15585	COG0028	Belongs to the TPP enzyme family
APT56_RS15595	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS15605	COG0400	carboxylic ester hydrolase activity
APT56_RS15610	COG0833	amino acid
APT56_RS15630	COG0587	DNA-directed DNA polymerase activity
APT56_RS15650	COG0667	Aldo Keto reductase
APT56_RS15660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APT56_RS15685	COG0765	amino acid transport
APT56_RS15690	COG0765	amino acid transport
APT56_RS15695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS15700	COG0436	Aminotransferase
APT56_RS15705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
APT56_RS15730	COG1309	transcriptional regulator
APT56_RS15735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APT56_RS15740	COG3038	cytochrome b561
APT56_RS15770	COG0840	transmembrane signaling receptor activity
APT56_RS15845	COG2764	glyoxalase bleomycin resistance protein dioxygenase
APT56_RS15860	COG1414	Transcriptional regulator
APT56_RS15870	COG0477	Major facilitator Superfamily
APT56_RS15875	COG0667	Aldo Keto reductase
APT56_RS15885	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS15890	COG1309	transcriptional regulator
APT56_RS15910	COG1683	Conserved Protein
APT56_RS15940	COG3047	cAMP biosynthetic process
APT56_RS15940	COG2885	chlorophyll binding
APT56_RS15945	COG3795	YCII-related domain
APT56_RS15950	COG3795	YCII-related domain
APT56_RS15960	COG4941	Belongs to the sigma-70 factor family
APT56_RS15970	COG0697	spore germination
APT56_RS15980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT56_RS15990	COG0583	DNA-binding transcription factor activity
APT56_RS16000	COG0456	acetyltransferase
APT56_RS16020	COG1846	Transcriptional regulator
APT56_RS16025	COG3541	Predicted nucleotidyltransferase
APT56_RS16045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_RS16075	COG2885	chlorophyll binding
APT56_RS16085	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
APT56_RS16265	COG0625	glutathione transferase activity
APT56_RS16275	COG2733	membrane
APT56_RS16285	COG0148	phosphopyruvate hydratase activity
APT56_RS16310	COG0583	DNA-binding transcription factor activity
APT56_RS16315	COG1024	Enoyl-CoA hydratase
APT56_RS16315	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_RS16320	COG0183	Belongs to the thiolase family
APT56_RS16325	COG1960	acyl-CoA dehydrogenase activity
APT56_RS16335	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_RS16345	COG2515	1-aminocyclopropane-1-carboxylate deaminase
APT56_RS16360	COG0583	DNA-binding transcription factor activity
APT56_RS16370	COG1846	Transcriptional regulator
APT56_RS16375	COG0477	Major facilitator Superfamily
APT56_RS16380	COG2010	Cytochrome c
APT56_RS16380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APT56_RS16385	COG2080	2 iron, 2 sulfur cluster binding
APT56_RS16395	COG0596	Alpha beta hydrolase
APT56_RS16400	COG2309	aminopeptidase activity
APT56_RS16405	COG1335	isochorismatase
APT56_RS16410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APT56_RS16410	COG2010	Cytochrome c
APT56_RS16430	COG1522	sequence-specific DNA binding
APT56_RS16435	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_RS16440	COG3842	ATPase activity
APT56_RS16445	COG1840	ABC-type Fe3 transport system, periplasmic component
APT56_RS16450	COG4149	molybdate abc transporter
APT56_RS16455	COG2203	Gaf domain
APT56_RS16455	COG3706	GGDEF domain
APT56_RS16455	COG4251	negative regulation of phosphorylation
APT56_RS16455	COG5001	Diguanylate cyclase
APT56_RS16485	COG0840	transmembrane signaling receptor activity
APT56_RS16490	COG0154	amidase activity
APT56_RS16500	COG0583	DNA-binding transcription factor activity
APT56_RS16515	COG1199	ATP-dependent helicase activity
APT56_RS16530	COG0456	acetyltransferase
APT56_RS16565	COG0477	Major facilitator Superfamily
APT56_RS16590	COG0583	DNA-binding transcription factor activity
APT56_RS16630	COG2267	carboxylic ester hydrolase activity
APT56_RS16650	COG2207	Transcriptional regulator
APT56_RS16670	COG1335	isochorismatase
APT56_RS16675	COG0583	DNA-binding transcription factor activity
APT56_RS16680	COG0640	Transcriptional regulator
APT56_RS16715	COG0519	Catalyzes the synthesis of GMP from XMP
APT56_RS16715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APT56_RS16745	COG0583	DNA-binding transcription factor activity
APT56_RS16755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT56_RS16780	COG0583	DNA-binding transcription factor activity
APT56_RS16785	COG3048	D-serine ammonia-lyase activity
APT56_RS16790	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS16820	COG2072	flavoprotein involved in K transport
APT56_RS16825	COG0601	transmembrane transport
APT56_RS16830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS16840	COG4608	Belongs to the ABC transporter superfamily
APT56_RS16845	COG0747	negative chemotaxis
APT56_RS16860	COG0583	DNA-binding transcription factor activity
APT56_RS16865	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS16870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APT56_RS16920	COG4774	siderophore transport
APT56_RS16960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT56_RS16985	COG0583	DNA-binding transcription factor activity
APT56_RS17020	COG1024	Enoyl-CoA hydratase
APT56_RS17030	COG1960	acyl-CoA dehydrogenase activity
APT56_RS17040	COG0583	DNA-binding transcription factor activity
APT56_RS17045	COG3618	amidohydrolase
APT56_RS17060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT56_RS17090	COG4774	siderophore transport
APT56_RS17100	COG5001	Diguanylate cyclase
APT56_RS17105	COG4774	siderophore transport
APT56_RS17150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APT56_RS17160	COG1953	Uracil, thiamine, allantoin
APT56_RS17185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS17185	COG0784	Response regulator, receiver
APT56_RS17185	COG2198	Histidine kinase
APT56_RS17185	COG2205	protein histidine kinase activity
APT56_RS17190	COG0745	RESPONSE REGULATOR receiver
APT56_RS17190	COG2205	protein histidine kinase activity
APT56_RS17190	COG3292	Two component regulator propeller
APT56_RS17215	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS17225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APT56_RS17240	COG0583	DNA-binding transcription factor activity
APT56_RS17260	COG0642	Histidine kinase
APT56_RS17285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APT56_RS17285	COG0047	phosphoribosylformylglycinamidine synthase activity
APT56_RS17295	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APT56_RS17295	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APT56_RS17300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_RS17310	COG0613	PHP domain protein
APT56_RS17330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APT56_RS17340	COG0583	DNA-binding transcription factor activity
APT56_RS17350	COG0583	DNA-binding transcription factor activity
APT56_RS17355	COG0477	Major facilitator Superfamily
APT56_RS17360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT56_RS17370	COG0159	tryptophan synthase activity
APT56_RS17390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APT56_RS17395	COG3093	addiction module antidote protein HigA
APT56_RS17420	COG2249	NAD(P)H dehydrogenase (quinone) activity
APT56_RS17430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APT56_RS17435	COG0459	protein refolding
APT56_RS17465	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS17470	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
APT56_RS17500	COG4604	ABC transporter, ATP-binding protein
APT56_RS17505	COG4605	iron ion homeostasis
APT56_RS17510	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_RS17515	COG4607	ABC-type enterochelin transport system periplasmic component
APT56_RS17520	COG4771	TonB-dependent receptor
APT56_RS17525	COG0745	RESPONSE REGULATOR receiver
APT56_RS17535	COG0084	hydrolase, TatD family'
APT56_RS17540	COG1136	(ABC) transporter
APT56_RS17565	COG2271	Major facilitator Superfamily
APT56_RS17570	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APT56_RS17575	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS17580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APT56_RS17595	COG3135	benzoate transporter
APT56_RS17600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APT56_RS17605	COG1309	transcriptional regulator
APT56_RS17610	COG0183	Belongs to the thiolase family
APT56_RS17615	COG1022	Amp-dependent synthetase and ligase
APT56_RS17645	COG1024	Enoyl-CoA hydratase
APT56_RS17655	COG1803	Methylglyoxal synthase
APT56_RS17660	COG2975	iron-sulfur cluster assembly
APT56_RS17665	COG0633	Ferredoxin
APT56_RS17670	COG0443	Heat shock 70 kDa protein
APT56_RS17675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APT56_RS17680	COG0316	Belongs to the HesB IscA family
APT56_RS17685	COG0822	iron-sulfur transferase activity
APT56_RS17690	COG1104	cysteine desulfurase activity
APT56_RS17700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APT56_RS17705	COG0556	nucleotide-excision repair
APT56_RS17715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APT56_RS17720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APT56_RS17725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APT56_RS17730	COG0740	serine-type endopeptidase activity
APT56_RS17735	COG0544	peptidyl-prolyl cis-trans isomerase activity
APT56_RS17740	COG0501	Belongs to the peptidase M48B family
APT56_RS17750	COG1278	Cold shock
APT56_RS17760	COG1278	Cold shock
APT56_RS17785	COG0251	oxidation-reduction process
APT56_RS17795	COG0583	DNA-binding transcription factor activity
APT56_RS17835	COG2877	3-deoxy-8-phosphooctulonate synthase activity
APT56_RS17860	COG0277	FAD linked oxidase domain protein
APT56_RS17870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APT56_RS17875	COG2271	Major facilitator Superfamily
APT56_RS17910	COG2171	N-acyltransferase activity
APT56_RS17920	COG2890	protein-(glutamine-N5) methyltransferase activity
APT56_RS17925	COG0488	(ABC) transporter
APT56_RS17940	COG4771	TonB-dependent receptor
APT56_RS17945	COG4771	TonB-dependent receptor
APT56_RS17950	COG1858	cytochrome C peroxidase
APT56_RS17960	COG0210	DNA helicase
APT56_RS17975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APT56_RS17975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT56_RS17980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APT56_RS17985	COG0196	riboflavin kinase activity
APT56_RS17990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APT56_RS17995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APT56_RS18000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APT56_RS18050	COG1902	pentaerythritol trinitrate reductase activity
APT56_RS18055	COG1126	abc transporter atp-binding protein
APT56_RS18060	COG0765	amino acid transport
APT56_RS18065	COG0765	amino acid transport
APT56_RS18070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS18085	COG1764	response to oxidative stress
APT56_RS18090	COG1914	H( )-stimulated, divalent metal cation uptake system
APT56_RS18100	COG1566	PFAM secretion protein HlyD family protein
APT56_RS18130	COG2271	Major facilitator Superfamily
APT56_RS18165	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APT56_RS18165	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APT56_RS18165	COG0506	proline dehydrogenase activity
APT56_RS18175	COG3008	intermembrane lipid transfer
APT56_RS18180	COG2995	paraquat-inducible protein a
APT56_RS18190	COG4953	penicillin-binding protein 1C
APT56_RS18195	COG2373	Large extracellular alpha-helical protein
APT56_RS18200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APT56_RS18205	COG1278	Cold shock
APT56_RS18215	COG0183	Belongs to the thiolase family
APT56_RS18220	COG0038	chloride channel
APT56_RS18230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APT56_RS18240	COG1570	exodeoxyribonuclease VII activity
APT56_RS18245	COG0811	peptide transport
APT56_RS18255	COG1663	tetraacyldisaccharide 4'-kinase activity
APT56_RS18265	COG2835	tetraacyldisaccharide 4'-kinase activity
APT56_RS18270	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APT56_RS18275	COG0563	adenylate kinase activity
APT56_RS18285	COG0728	peptidoglycan biosynthetic process
APT56_RS18295	COG0268	Binds directly to 16S ribosomal RNA
APT56_RS18300	COG0583	DNA-binding transcription factor activity
APT56_RS18315	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS18320	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APT56_RS18325	COG2186	Transcriptional regulator
APT56_RS18335	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS18345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT56_RS18375	COG3384	dioxygenase
APT56_RS18380	COG1012	belongs to the aldehyde dehydrogenase family
APT56_RS18395	COG3971	2-oxopent-4-enoate hydratase activity
APT56_RS18405	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS18410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APT56_RS18420	COG1562	ergosterol biosynthetic process
APT56_RS18430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
APT56_RS18445	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
APT56_RS18460	COG5564	TIM-barrel signal transduction protein
APT56_RS18465	COG5441	Belongs to the UPF0261 family
APT56_RS18490	COG0542	response to heat
APT56_RS18500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT56_RS18510	COG0477	Major facilitator Superfamily
APT56_RS18515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT56_RS18525	COG0494	nUDIX hydrolase
APT56_RS18530	COG0443	Heat shock 70 kDa protein
APT56_RS18565	COG2814	Major facilitator Superfamily
APT56_RS18575	COG3530	Putative quorum-sensing-regulated virulence factor
APT56_RS18590	COG0625	glutathione transferase activity
APT56_RS18620	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS18630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APT56_RS18650	COG3386	PFAM SMP-30 Gluconolaconase
APT56_RS18690	COG1522	sequence-specific DNA binding
APT56_RS18715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS18725	COG0519	Catalyzes the synthesis of GMP from XMP
APT56_RS18745	COG0519	Catalyzes the synthesis of GMP from XMP
APT56_RS18750	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
APT56_RS18755	COG2951	lytic endotransglycosylase activity
APT56_RS18765	COG0583	DNA-binding transcription factor activity
APT56_RS18780	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS18785	COG1309	transcriptional regulator
APT56_RS18795	COG1473	amidohydrolase
APT56_RS18800	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS18810	COG3153	acetyltransferase
APT56_RS18815	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
APT56_RS18830	COG3618	amidohydrolase
APT56_RS18835	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS18870	COG2011	ABC-type metal ion transport system permease component
APT56_RS18875	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APT56_RS18880	COG1464	Belongs to the NlpA lipoprotein family
APT56_RS18925	COG2837	iron assimilation
APT56_RS18945	COG2169	Transcriptional regulator
APT56_RS18975	COG1272	protein, Hemolysin III
APT56_RS19015	COG0604	alcohol dehydrogenase
APT56_RS19015	COG3321	synthase
APT56_RS19025	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_RS19030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_RS19055	COG0183	Belongs to the thiolase family
APT56_RS19070	COG0842	Transport permease protein
APT56_RS19075	COG1131	(ABC) transporter
APT56_RS19085	COG2197	response regulator
APT56_RS19090	COG1116	anion transmembrane transporter activity
APT56_RS19090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_RS19095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_RS19100	COG1116	anion transmembrane transporter activity
APT56_RS19105	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
APT56_RS19155	COG0811	peptide transport
APT56_RS19215	COG1396	sequence-specific DNA binding
APT56_RS19230	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS19260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS19290	COG0583	DNA-binding transcription factor activity
APT56_RS19295	COG2814	Major facilitator Superfamily
APT56_RS19300	COG2199	diguanylate cyclase activity
APT56_RS19315	COG0500	methyltransferase
APT56_RS19330	COG1609	Transcriptional regulator
APT56_RS19335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_RS19340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APT56_RS19350	COG1850	ribulose-bisphosphate carboxylase activity
APT56_RS19360	COG3608	succinylglutamate desuccinylase aspartoacylase
APT56_RS19360	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APT56_RS19375	COG1064	alcohol dehydrogenase
APT56_RS19380	COG2207	Transcriptional regulator
APT56_RS19395	COG1113	amino acid transport
APT56_RS19410	COG1058	Belongs to the CinA family
APT56_RS19410	COG1546	Belongs to the CinA family
APT56_RS19420	COG3852	Histidine kinase
APT56_RS19445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT56_RS19455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APT56_RS19465	COG0477	Major facilitator Superfamily
APT56_RS19470	COG1595	DNA-templated transcription, initiation
APT56_RS19480	COG4774	siderophore transport
APT56_RS19490	COG4206	TonB-dependent receptor
APT56_RS19505	COG1120	ATPase activity
APT56_RS19510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_RS19515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APT56_RS19520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APT56_RS19540	COG0596	Alpha beta hydrolase
APT56_RS19555	COG1414	Transcriptional regulator
APT56_RS19560	COG0179	Fumarylacetoacetate (FAA) hydrolase
APT56_RS19565	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS19575	COG2721	sulfolactate sulfo-lyase activity
APT56_RS19585	COG0765	amino acid transport
APT56_RS19595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS19600	COG4948	Mandelate Racemase Muconate Lactonizing
APT56_RS19610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APT56_RS19615	COG3958	Transketolase
APT56_RS19620	COG3959	Transketolase, thiamine diphosphate binding domain
APT56_RS19625	COG1802	Transcriptional regulator
APT56_RS19630	COG0371	Dehydrogenase
APT56_RS19635	COG3246	L-lysine catabolic process to acetate
APT56_RS19645	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS19655	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_RS19670	COG4221	oxidoreductase activity
APT56_RS19670	COG3321	synthase
APT56_RS19670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APT56_RS19670	COG0604	alcohol dehydrogenase
APT56_RS19675	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS19695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APT56_RS19705	COG3384	dioxygenase
APT56_RS19720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APT56_RS19775	COG4964	Belongs to the GSP D family
APT56_RS19820	COG1846	Transcriptional regulator
APT56_RS19825	COG4172	Belongs to the ABC transporter superfamily
APT56_RS19830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS19850	COG0598	Magnesium transport protein CorA
APT56_RS19870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APT56_RS19880	COG0483	inositol monophosphate 1-phosphatase activity
APT56_RS19885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT56_RS19890	COG1045	serine acetyltransferase
APT56_RS19895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APT56_RS19900	COG0166	Belongs to the GPI family
APT56_RS19920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APT56_RS19925	COG1051	belongs to the nudix hydrolase family
APT56_RS19945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT56_RS19970	COG0463	Glycosyl transferase, family 2
APT56_RS19975	COG0110	maltose O-acetyltransferase activity
APT56_RS19980	COG0297	glycogen (starch) synthase activity
APT56_RS19985	COG2197	response regulator
APT56_RS19990	COG2197	response regulator
APT56_RS20000	COG1309	transcriptional regulator
APT56_RS20005	COG1960	acyl-CoA dehydrogenase activity
APT56_RS20015	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_RS20015	COG1024	Enoyl-CoA hydratase
APT56_RS20025	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_RS20025	COG1024	Enoyl-CoA hydratase
APT56_RS20030	COG0183	Belongs to the thiolase family
APT56_RS20045	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_RS20055	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS20065	COG1132	(ABC) transporter
APT56_RS20075	COG3395	kinase activity
APT56_RS20080	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APT56_RS20090	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APT56_RS20095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
APT56_RS20110	COG1414	Transcriptional regulator
APT56_RS20120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APT56_RS20145	COG0583	DNA-binding transcription factor activity
APT56_RS20155	COG0456	acetyltransferase
APT56_RS20185	COG1309	transcriptional regulator
APT56_RS20195	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
APT56_RS20205	COG0784	Response regulator, receiver
APT56_RS20205	COG2205	protein histidine kinase activity
APT56_RS20215	COG0784	Response regulator, receiver
APT56_RS20215	COG2205	protein histidine kinase activity
APT56_RS20235	COG0527	aspartate kinase activity
APT56_RS20240	COG0037	tRNA processing
APT56_RS20245	COG0825	malonyl-CoA metabolic process
APT56_RS20255	COG0215	cysteine-tRNA ligase activity
APT56_RS20265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APT56_RS20270	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APT56_RS20275	COG1968	undecaprenyl-diphosphatase activity
APT56_RS20280	COG1253	flavin adenine dinucleotide binding
APT56_RS20285	COG0483	inositol monophosphate 1-phosphatase activity
APT56_RS20305	COG0668	transmembrane transport
APT56_RS20345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_RS20350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_RS20390	COG3360	Dodecin
APT56_RS20400	COG0583	DNA-binding transcription factor activity
APT56_RS20405	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS20440	COG0583	DNA-binding transcription factor activity
APT56_RS20460	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APT56_RS20465	COG2850	peptidyl-arginine hydroxylation
APT56_RS20475	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
APT56_RS20480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_RS20485	COG1994	Peptidase M50
APT56_RS20490	COG0009	L-threonylcarbamoyladenylate synthase
APT56_RS20495	COG2321	neutral zinc metallopeptidase
APT56_RS20550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT56_RS20555	COG1971	Probably functions as a manganese efflux pump
APT56_RS20560	COG3969	phosphoadenosine phosphosulfate
APT56_RS20565	COG1475	DNA binding
APT56_RS20570	COG0642	Histidine kinase
APT56_RS20590	COG3188	usher protein
APT56_RS20595	COG3121	Chaperone
APT56_RS20610	COG5001	Diguanylate cyclase
APT56_RS20610	COG3300	MHYT domain
APT56_RS20615	COG2205	protein histidine kinase activity
APT56_RS20615	COG0784	Response regulator, receiver
APT56_RS20620	COG2197	response regulator
APT56_RS20650	COG3121	Chaperone
APT56_RS20655	COG3188	usher protein
APT56_RS20665	COG0840	transmembrane signaling receptor activity
APT56_RS20700	COG0840	transmembrane signaling receptor activity
APT56_RS20705	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS20760	COG1917	Cupin 2, conserved barrel domain protein
APT56_RS20760	COG2207	Transcriptional regulator
APT56_RS20770	COG2084	Dehydrogenase
APT56_RS20780	COG0583	DNA-binding transcription factor activity
APT56_RS20795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APT56_RS20810	COG1802	Transcriptional regulator
APT56_RS20850	COG2205	protein histidine kinase activity
APT56_RS20855	COG1764	response to oxidative stress
APT56_RS20860	COG0583	DNA-binding transcription factor activity
APT56_RS20865	COG0601	transmembrane transport
APT56_RS20870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS20875	COG0444	Belongs to the ABC transporter superfamily
APT56_RS20880	COG4608	Belongs to the ABC transporter superfamily
APT56_RS20895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_RS20900	COG0586	Pfam SNARE associated Golgi protein
APT56_RS20905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_RS20910	COG0583	DNA-binding transcription factor activity
APT56_RS20925	COG1566	PFAM secretion protein HlyD family protein
APT56_RS20945	COG0438	transferase activity, transferring glycosyl groups
APT56_RS20950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
APT56_RS20975	COG1396	sequence-specific DNA binding
APT56_RS20980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_RS20985	COG0765	amino acid transport
APT56_RS20995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS21005	COG1012	belongs to the aldehyde dehydrogenase family
APT56_RS21030	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS21050	COG0348	domain, Protein
APT56_RS21070	COG3278	Belongs to the heme-copper respiratory oxidase family
APT56_RS21090	COG0156	8-amino-7-oxononanoate synthase activity
APT56_RS21100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APT56_RS21100	COG4106	trans-aconitate 2-methyltransferase activity
APT56_RS21105	COG4106	trans-aconitate 2-methyltransferase activity
APT56_RS21105	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APT56_RS21120	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APT56_RS21135	COG0583	DNA-binding transcription factor activity
APT56_RS21140	COG2224	Isocitrate lyase
APT56_RS21145	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APT56_RS21145	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APT56_RS21150	COG1858	cytochrome C peroxidase
APT56_RS21155	COG0583	DNA-binding transcription factor activity
APT56_RS21160	COG0473	3-isopropylmalate dehydrogenase activity
APT56_RS21170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APT56_RS21185	COG0736	holo-[acyl-carrier-protein] synthase activity
APT56_RS21190	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APT56_RS21200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APT56_RS21205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_RS21230	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APT56_RS21235	COG4149	molybdate abc transporter
APT56_RS21240	COG0725	ABC transporter, periplasmic molybdate-binding protein
APT56_RS21245	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APT56_RS21265	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APT56_RS21275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APT56_RS21290	COG4120	Belongs to the binding-protein-dependent transport system permease family
APT56_RS21300	COG0667	Aldo Keto reductase
APT56_RS21310	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_RS21315	COG1024	Enoyl-CoA hydratase
APT56_RS21325	COG1802	Transcriptional regulator
APT56_RS21335	COG0183	Belongs to the thiolase family
APT56_RS21340	COG1960	acyl-CoA dehydrogenase activity
APT56_RS21345	COG1960	acyl-CoA dehydrogenase activity
APT56_RS21350	COG0583	DNA-binding transcription factor activity
APT56_RS21375	COG4213	ABC transporter substrate-binding protein
APT56_RS21380	COG1129	ABC transporter
APT56_RS21385	COG4214	carbohydrate transport
APT56_RS21390	COG2706	6-phosphogluconolactonase activity
APT56_RS21395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT56_RS21415	COG4176	ABC-type proline glycine betaine transport system permease component
APT56_RS21425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APT56_RS21430	COG2814	Major facilitator Superfamily
APT56_RS21435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APT56_RS21440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APT56_RS21475	COG1686	Belongs to the peptidase S11 family
APT56_RS21485	COG1846	Transcriptional regulator
APT56_RS21490	COG2814	Major facilitator Superfamily
APT56_RS21495	COG0495	leucyl-tRNA aminoacylation
APT56_RS21510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APT56_RS21530	COG0154	amidase activity
APT56_RS21540	COG0477	Major facilitator Superfamily
APT56_RS21550	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_RS21565	COG0583	DNA-binding transcription factor activity
APT56_RS21615	COG0583	DNA-binding transcription factor activity
APT56_RS21620	COG0427	acetyl-CoA hydrolase
APT56_RS21625	COG0583	DNA-binding transcription factor activity
APT56_RS21630	COG3264	Mechanosensitive ion channel
APT56_RS21630	COG1511	domain protein
APT56_RS21690	COG3842	ATPase activity
APT56_RS21695	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT56_RS21700	COG1177	transmembrane transport
APT56_RS21705	COG3938	Belongs to the proline racemase family
APT56_RS21720	COG0517	IMP dehydrogenase activity
APT56_RS21750	COG0500	methyltransferase
APT56_RS21755	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APT56_RS21775	COG0667	Aldo Keto reductase
APT56_RS21780	COG2207	Transcriptional regulator
APT56_RS21790	COG1595	DNA-templated transcription, initiation
APT56_RS21805	COG2841	Protein conserved in bacteria
APT56_RS21820	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APT56_RS21825	COG0477	Major facilitator Superfamily
APT56_RS21835	COG2814	Major facilitator Superfamily
APT56_RS21840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APT56_RS21875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APT56_RS21885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APT56_RS21890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
APT56_RS21895	COG1534	Rna-binding protein
APT56_RS21900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APT56_RS21905	COG0840	transmembrane signaling receptor activity
APT56_RS21910	COG2233	PERMEase
APT56_RS21930	COG3842	ATPase activity
APT56_RS21940	COG0406	alpha-ribazole phosphatase activity
APT56_RS21945	COG4221	oxidoreductase activity
APT56_RS21955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APT56_RS21960	COG0505	Belongs to the CarA family
APT56_RS21980	COG0745	RESPONSE REGULATOR receiver
APT56_RS21995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APT56_RS22005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_RS22010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_RS22025	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APT56_RS22035	COG1074	ATP-dependent DNA helicase activity
APT56_RS22050	COG2070	2-Nitropropane dioxygenase
APT56_RS22070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_RS22075	COG1024	Enoyl-CoA hydratase
APT56_RS22085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT56_RS22090	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_RS22105	COG1686	Belongs to the peptidase S11 family
APT56_RS22125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APT56_RS22130	COG4974	Belongs to the 'phage' integrase family
APT56_RS22135	COG0583	DNA-binding transcription factor activity
APT56_RS22140	COG0028	Belongs to the TPP enzyme family
APT56_RS22170	COG2030	dehydratase
APT56_RS22190	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APT56_RS22235	COG0028	Belongs to the TPP enzyme family
APT56_RS22240	COG1126	abc transporter atp-binding protein
APT56_RS22245	COG0765	amino acid transport
APT56_RS22255	COG0010	Belongs to the arginase family
APT56_RS22260	COG1414	Transcriptional regulator
APT56_RS22265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS22280	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APT56_RS22285	COG1414	Transcriptional regulator
APT56_RS22290	COG0009	L-threonylcarbamoyladenylate synthase
APT56_RS22295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APT56_RS22300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APT56_RS22305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
APT56_RS22310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APT56_RS22335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS22350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APT56_RS22365	COG1301	dicarboxylic acid transport
APT56_RS22385	COG3454	Phosphonate metabolism
APT56_RS22390	COG4778	phosphonate C-P lyase system protein PhnL
APT56_RS22395	COG4107	phosphonate C-P lyase system protein PhnK
APT56_RS22400	COG3627	carbon phosphorus lyase activity
APT56_RS22405	COG3626	phosphonate metabolism
APT56_RS22410	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
APT56_RS22415	COG3624	Phosphonate C-P lyase system protein PhnG
APT56_RS22420	COG2188	Transcriptional regulator
APT56_RS22425	COG3454	Phosphonate metabolism
APT56_RS22430	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
APT56_RS22435	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
APT56_RS22440	COG0583	DNA-binding transcription factor activity
APT56_RS22460	COG3639	organic phosphonate transmembrane transporter activity
APT56_RS22465	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
APT56_RS22470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
APT56_RS22480	COG0640	Transcriptional regulator
APT56_RS22490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APT56_RS22500	COG0739	heme binding
APT56_RS22510	COG0521	Mo-molybdopterin cofactor biosynthetic process
APT56_RS22520	COG0306	phosphate transporter
APT56_RS22555	COG0625	glutathione transferase activity
APT56_RS22575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APT56_RS22580	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APT56_RS22595	COG0126	phosphoglycerate kinase activity
APT56_RS22600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APT56_RS22605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APT56_RS22615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APT56_RS22620	COG2732	(Barnase) inhibitor
APT56_RS22630	COG0280	phosphate acetyltransferase
APT56_RS22630	COG0281	malic enzyme
APT56_RS22640	COG0436	Aminotransferase
APT56_RS22645	COG0741	lytic transglycosylase activity
APT56_RS22650	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APT56_RS22665	COG4575	ribosome binding
APT56_RS22675	COG1116	anion transmembrane transporter activity
APT56_RS22685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APT56_RS22690	COG1648	precorrin-2 dehydrogenase activity
APT56_RS22690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APT56_RS22695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APT56_RS22700	COG2027	D-alanyl-D-alanine carboxypeptidase
APT56_RS22715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APT56_RS22725	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APT56_RS22730	COG0343	queuine tRNA-ribosyltransferase activity
APT56_RS22735	COG1862	Preprotein translocase
APT56_RS22740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT56_RS22745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT56_RS22755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APT56_RS22765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APT56_RS22770	COG1702	phosphate starvation-inducible protein PhoH
APT56_RS22775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APT56_RS22780	COG4535	Mg2 and Co2 transporter CorC
APT56_RS22785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APT56_RS22790	COG0667	Aldo Keto reductase
APT56_RS22835	COG0697	spore germination
APT56_RS22845	COG0678	peroxiredoxin activity
APT56_RS22855	COG0412	Dienelactone hydrolase
APT56_RS22865	COG0315	cyclic pyranopterin monophosphate synthase activity
APT56_RS22875	COG0314	molybdopterin synthase activity
APT56_RS22880	COG0521	Mo-molybdopterin cofactor biosynthetic process
APT56_RS22895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APT56_RS22915	COG3383	formate dehydrogenase (NAD+) activity
APT56_RS22920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
APT56_RS22930	COG2223	nitrite transmembrane transporter activity
APT56_RS22955	COG0583	DNA-binding transcription factor activity
APT56_RS22960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APT56_RS22995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APT56_RS23010	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS23030	COG2828	Protein conserved in bacteria
APT56_RS23035	COG0583	DNA-binding transcription factor activity
APT56_RS23040	COG0456	acetyltransferase
APT56_RS23085	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_RS23110	COG4774	siderophore transport
APT56_RS23125	COG0671	phosphoesterase, PA-phosphatase related
APT56_RS23140	COG1666	GTP binding
APT56_RS23145	COG1120	ATPase activity
APT56_RS23150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APT56_RS23155	COG4558	Periplasmic binding protein
APT56_RS23160	COG3720	iron ion transport
APT56_RS23170	COG3712	iron ion homeostasis
APT56_RS23175	COG1595	DNA-templated transcription, initiation
APT56_RS23205	COG2378	regulation of single-species biofilm formation
APT56_RS23235	COG1113	amino acid transport
APT56_RS23245	COG1522	sequence-specific DNA binding
APT56_RS23250	COG1272	protein, Hemolysin III
APT56_RS23255	COG3191	aminopeptidase activity
APT56_RS23260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS23265	COG0765	amino acid transport
APT56_RS23270	COG1126	abc transporter atp-binding protein
APT56_RS23295	COG1999	signal sequence binding
APT56_RS23315	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
APT56_RS23325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APT56_RS23330	COG1845	cytochrome c oxidase, subunit III
APT56_RS23335	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APT56_RS23355	COG4772	TonB-dependent receptor
APT56_RS23375	COG0281	malic enzyme
APT56_RS23375	COG0280	phosphate acetyltransferase
APT56_RS23390	COG0697	spore germination
APT56_RS23425	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS23435	COG0583	DNA-binding transcription factor activity
APT56_RS23450	COG0456	acetyltransferase
APT56_RS23455	COG1396	sequence-specific DNA binding
APT56_RS23460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APT56_RS23470	COG3145	DNA-N1-methyladenine dioxygenase activity
APT56_RS23475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APT56_RS23490	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
APT56_RS23495	COG1285	pathogenesis
APT56_RS23500	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS23505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APT56_RS23510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APT56_RS23520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APT56_RS23535	COG3712	iron ion homeostasis
APT56_RS23550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APT56_RS23555	COG0330	HflC and HflK could
APT56_RS23580	COG2807	transmembrane transport
APT56_RS23585	COG2207	Transcriptional regulator
APT56_RS23590	COG4106	trans-aconitate 2-methyltransferase activity
APT56_RS23605	COG0583	DNA-binding transcription factor activity
APT56_RS23645	COG0477	Major facilitator Superfamily
APT56_RS23650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APT56_RS23655	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APT56_RS23660	COG1845	cytochrome c oxidase, subunit III
APT56_RS23665	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APT56_RS23675	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_RS23680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_RS23690	COG2814	Major facilitator Superfamily
APT56_RS23700	COG0625	glutathione transferase activity
APT56_RS23725	COG2197	response regulator
APT56_RS23750	COG3707	response regulator
APT56_RS23755	COG2146	nitrite reductase [NAD(P)H] activity
APT56_RS23755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APT56_RS23760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APT56_RS23760	COG2146	nitrite reductase [NAD(P)H] activity
APT56_RS23765	COG0243	molybdopterin cofactor binding
APT56_RS23770	COG0667	Aldo Keto reductase
APT56_RS23775	COG0656	L-ascorbic acid biosynthetic process
APT56_RS23780	COG0583	DNA-binding transcription factor activity
APT56_RS23785	COG0023	Translation Initiation Factor
APT56_RS23815	COG0840	transmembrane signaling receptor activity
APT56_RS23820	COG2203	Gaf domain
APT56_RS23820	COG2199	diguanylate cyclase activity
APT56_RS23825	COG0640	Transcriptional regulator
APT56_RS23835	COG0740	serine-type endopeptidase activity
APT56_RS23860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_RS23870	COG0596	Alpha beta hydrolase
APT56_RS23915	COG0028	Belongs to the TPP enzyme family
APT56_RS23935	COG1230	cation diffusion facilitator family transporter
APT56_RS23955	COG2375	cellular response to nickel ion
APT56_RS23955	COG1132	(ABC) transporter
APT56_RS23965	COG1201	RNA secondary structure unwinding
APT56_RS23970	COG1793	dna ligase
APT56_RS23985	COG0798	PFAM Bile acid sodium symporter
APT56_RS23990	COG1393	Belongs to the ArsC family
APT56_RS23995	COG0431	NADPH-dependent FMN reductase
APT56_RS24010	COG0697	spore germination
APT56_RS24045	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APT56_RS24085	COG0745	RESPONSE REGULATOR receiver
APT56_RS24095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APT56_RS24120	COG0793	Belongs to the peptidase S41A family
APT56_RS24165	COG2200	EAL domain
APT56_RS24190	COG4191	Histidine kinase
APT56_RS24205	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS24220	COG1686	Belongs to the peptidase S11 family
APT56_RS24260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APT56_RS24265	COG0459	protein refolding
APT56_RS24275	COG1846	Transcriptional regulator
APT56_RS24295	COG1917	Cupin 2, conserved barrel domain protein
APT56_RS24320	COG1137	ATPase activity
APT56_RS24330	COG0246	Mannitol dehydrogenase
APT56_RS24335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APT56_RS24340	COG1252	NADH dehydrogenase
APT56_RS24345	COG0284	orotidine-5'-phosphate decarboxylase activity
APT56_RS24350	COG1546	Belongs to the CinA family
APT56_RS24355	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APT56_RS24360	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APT56_RS24365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT56_RS24370	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APT56_RS24395	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
APT56_RS24400	COG3639	organic phosphonate transmembrane transporter activity
APT56_RS24405	COG3639	organic phosphonate transmembrane transporter activity
APT56_RS24420	COG0742	ribosomal rna small subunit methyltransferase
APT56_RS24425	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APT56_RS24430	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APT56_RS24435	COG3135	benzoate transporter
APT56_RS24450	COG2814	Major facilitator Superfamily
APT56_RS24465	COG0488	(ABC) transporter
APT56_RS24475	COG0012	GTP binding
APT56_RS24485	COG0193	aminoacyl-tRNA hydrolase activity
APT56_RS24505	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APT56_RS24510	COG0840	transmembrane signaling receptor activity
APT56_RS24525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APT56_RS24550	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
APT56_RS24560	COG0204	Acyl-transferase
APT56_RS24565	COG1368	sulfuric ester hydrolase activity
APT56_RS24570	COG2186	Transcriptional regulator
APT56_RS24575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT56_RS24585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APT56_RS24595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APT56_RS24595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APT56_RS24605	COG2205	protein histidine kinase activity
APT56_RS24610	COG0745	RESPONSE REGULATOR receiver
APT56_RS24615	COG0277	FAD linked oxidase domain protein
APT56_RS24630	COG0166	Belongs to the GPI family
APT56_RS24635	COG0405	Gamma-glutamyltransferase
APT56_RS24645	COG0438	transferase activity, transferring glycosyl groups
APT56_RS24650	COG0438	transferase activity, transferring glycosyl groups
APT56_RS24660	COG0438	transferase activity, transferring glycosyl groups
APT56_RS24675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APT56_RS24680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APT56_RS24685	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
APT56_RS24710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_RS24715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APT56_RS24730	COG0747	negative chemotaxis
APT56_RS24735	COG0601	transmembrane transport
APT56_RS24740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APT56_RS24745	COG4172	Belongs to the ABC transporter superfamily
APT56_RS24750	COG0154	amidase activity
APT56_RS24765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APT56_RS24765	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APT56_RS24770	COG0509	glycine decarboxylation via glycine cleavage system
APT56_RS24775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APT56_RS24790	COG2081	HI0933 family
APT56_RS24810	COG3706	GGDEF domain
APT56_RS24820	COG0717	Belongs to the dCTP deaminase family
APT56_RS24835	COG0489	protein tyrosine kinase activity
APT56_RS24845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT56_RS24845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APT56_RS24850	COG1054	Belongs to the UPF0176 family
APT56_RS24875	COG0745	RESPONSE REGULATOR receiver
APT56_RS24880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APT56_RS24905	COG2200	EAL domain
APT56_RS24915	COG3243	poly(R)-hydroxyalkanoic acid synthase
APT56_RS24925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_RS24930	COG0842	Transport permease protein
APT56_RS24930	COG1129	ABC transporter
APT56_RS24935	COG0842	Transport permease protein
APT56_RS24945	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS24950	COG1271	oxidase subunit
APT56_RS24955	COG1294	oxidase, subunit
APT56_RS24960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_RS24980	COG0411	ABC transporter
APT56_RS25000	COG0784	Response regulator, receiver
APT56_RS25000	COG2205	protein histidine kinase activity
APT56_RS25000	COG2198	Histidine kinase
APT56_RS25000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS25005	COG3437	response regulator, receiver
APT56_RS25040	COG3258	Cytochrome c
APT56_RS25050	COG0625	glutathione transferase activity
APT56_RS25070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APT56_RS25110	COG0257	Belongs to the bacterial ribosomal protein bL36 family
APT56_RS25125	COG2828	Protein conserved in bacteria
APT56_RS25135	COG0165	Argininosuccinate lyase
APT56_RS25140	COG2205	protein histidine kinase activity
APT56_RS25145	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS25150	COG3246	L-lysine catabolic process to acetate
APT56_RS25170	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APT56_RS25205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT56_RS25210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APT56_RS25215	COG0583	DNA-binding transcription factor activity
APT56_RS25220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APT56_RS25235	COG1652	LysM domain
APT56_RS25240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APT56_RS25245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APT56_RS25260	COG0625	glutathione transferase activity
APT56_RS25290	COG1012	belongs to the aldehyde dehydrogenase family
APT56_RS25335	COG1414	Transcriptional regulator
APT56_RS25345	COG0800	Aldolase
APT56_RS25350	COG4948	Mandelate Racemase Muconate Lactonizing
APT56_RS25355	COG2271	Major facilitator Superfamily
APT56_RS25360	COG1131	(ABC) transporter
APT56_RS25375	COG4774	siderophore transport
APT56_RS25380	COG2814	Major facilitator Superfamily
APT56_RS25390	COG1396	sequence-specific DNA binding
APT56_RS25395	COG0326	Molecular chaperone. Has ATPase activity
APT56_RS25405	COG2233	PERMEase
APT56_RS25430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APT56_RS25480	COG3657	addiction module killer protein
APT56_RS25495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS25500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APT56_RS25515	COG1172	Belongs to the binding-protein-dependent transport system permease family
APT56_RS25520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APT56_RS25530	COG3246	L-lysine catabolic process to acetate
APT56_RS25540	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS25545	COG0583	DNA-binding transcription factor activity
APT56_RS25650	COG0745	RESPONSE REGULATOR receiver
APT56_RS25675	COG0583	DNA-binding transcription factor activity
APT56_RS25685	COG1695	Transcriptional regulator
APT56_RS25700	COG0477	Major facilitator Superfamily
APT56_RS25715	COG0277	FAD linked oxidase domain protein
APT56_RS25725	COG3842	ATPase activity
APT56_RS25730	COG1176	ABC-type spermidine putrescine transport system, permease component I
APT56_RS25750	COG0628	permease
APT56_RS25755	COG0583	DNA-binding transcription factor activity
APT56_RS25760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APT56_RS25810	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
APT56_RS25820	COG2186	Transcriptional regulator
APT56_RS25830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APT56_RS25855	COG0410	ABC transporter
APT56_RS25860	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS25865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APT56_RS25875	COG0508	dehydrogenase complex catalyzes the overall conversion of
APT56_RS25880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APT56_RS25885	COG0583	DNA-binding transcription factor activity
APT56_RS25890	COG0129	dihydroxy-acid dehydratase activity
APT56_RS25900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APT56_RS25905	COG0583	DNA-binding transcription factor activity
APT56_RS25925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APT56_RS25930	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APT56_RS25935	COG1250	3-hydroxyacyl-CoA dehydrogenase
APT56_RS25940	COG2031	fatty acid transporter
APT56_RS25945	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS25950	COG1414	Transcriptional regulator
APT56_RS25960	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APT56_RS25965	COG4829	muconolactone delta-isomerase
APT56_RS25975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT56_RS25995	COG0288	reversible hydration of carbon dioxide
APT56_RS26000	COG1802	Transcriptional regulator
APT56_RS26005	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS26015	COG0559	Belongs to the binding-protein-dependent transport system permease family
APT56_RS26035	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS26045	COG1053	succinate dehydrogenase
APT56_RS26050	COG0625	glutathione transferase activity
APT56_RS26065	COG0583	DNA-binding transcription factor activity
APT56_RS26075	COG0583	DNA-binding transcription factor activity
APT56_RS26080	COG0477	Major facilitator Superfamily
APT56_RS26105	COG0318	PFAM AMP-dependent synthetase and ligase
APT56_RS26125	COG1464	Belongs to the NlpA lipoprotein family
APT56_RS26140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APT56_RS26145	COG2890	protein-(glutamine-N5) methyltransferase activity
APT56_RS26150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APT56_RS26165	COG1280	lysine exporter protein (LysE YggA)
APT56_RS26170	COG1522	sequence-specific DNA binding
APT56_RS26190	COG3622	Belongs to the hyi family
APT56_RS26215	COG2186	Transcriptional regulator
APT56_RS26220	COG3395	kinase activity
APT56_RS26225	COG2084	Dehydrogenase
APT56_RS26230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APT56_RS26235	COG3622	Belongs to the hyi family
APT56_RS26240	COG0235	Class ii aldolase
APT56_RS26280	COG2814	Major facilitator Superfamily
APT56_RS26285	COG0583	DNA-binding transcription factor activity
APT56_RS26295	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS26300	COG0183	Belongs to the thiolase family
APT56_RS26305	COG4580	involved in the transport of maltose and maltodextrins
APT56_RS26315	COG0142	geranyltranstransferase activity
APT56_RS26320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APT56_RS26325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APT56_RS26330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APT56_RS26335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APT56_RS26350	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT56_RS26350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APT56_RS26355	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APT56_RS26365	COG2186	Transcriptional regulator
APT56_RS26370	COG5001	Diguanylate cyclase
APT56_RS26370	COG5002	protein histidine kinase activity
APT56_RS26370	COG3447	MASE1 domain protein
APT56_RS26375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APT56_RS26380	COG0793	Belongs to the peptidase S41A family
APT56_RS26385	COG4942	peptidase
APT56_RS26390	COG0588	phosphoglycerate mutase activity
APT56_RS26395	COG1054	Belongs to the UPF0176 family
APT56_RS26400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APT56_RS26405	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
APT56_RS26410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APT56_RS26430	COG2226	methyltransferase
APT56_RS26435	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APT56_RS26440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APT56_RS26445	COG0569	domain protein
APT56_RS26450	COG2204	response regulator
APT56_RS26455	COG5000	phosphorelay sensor kinase activity
APT56_RS26465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APT56_RS26465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APT56_RS26470	COG1280	lysine exporter protein (LysE YggA)
APT56_RS26475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APT56_RS26485	COG1733	regulation of RNA biosynthetic process
APT56_RS26505	COG0546	phosphoglycolate phosphatase activity
APT56_RS26515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APT56_RS26520	COG0242	peptide deformylase activity
APT56_RS26525	COG0758	DNA mediated transformation
APT56_RS26540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APT56_RS26545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_RS26550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APT56_RS26555	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS26570	COG1238	metal cluster binding
APT56_RS26575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APT56_RS26580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APT56_RS26595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APT56_RS26600	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APT56_RS26605	COG4988	ABC transporter
APT56_RS26615	COG1294	oxidase, subunit
APT56_RS26630	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
APT56_RS26640	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APT56_RS26655	COG1137	ATPase activity
APT56_RS26660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APT56_RS26670	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
APT56_RS26675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_RS26690	COG1660	Displays ATPase and GTPase activities
APT56_RS26700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APT56_RS26710	COG0792	nuclease activity
APT56_RS26715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
APT56_RS26725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APT56_RS26735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APT56_RS26745	COG1309	transcriptional regulator
APT56_RS26750	COG0471	metal ion transport
APT56_RS26755	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APT56_RS26760	COG0772	Belongs to the SEDS family
APT56_RS26765	COG0768	penicillin binding
APT56_RS26775	COG1792	Involved in formation and maintenance of cell shape
APT56_RS26780	COG1077	Cell shape determining protein MreB Mrl
APT56_RS26785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APT56_RS26790	COG0154	amidase activity
APT56_RS26795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APT56_RS26805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APT56_RS26810	COG0708	Exodeoxyribonuclease III
APT56_RS26815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APT56_RS26825	COG0583	DNA-binding transcription factor activity
APT56_RS26840	COG0583	DNA-binding transcription factor activity
APT56_RS26865	COG1764	response to oxidative stress
APT56_RS26870	COG1846	Transcriptional regulator
APT56_RS26930	COG0640	Transcriptional regulator
APT56_RS26955	COG0297	glycogen (starch) synthase activity
APT56_RS26965	COG3189	MarR family transcriptional regulator
APT56_RS26985	COG1028	Short-chain dehydrogenase reductase Sdr
APT56_RS26990	COG0351	phosphomethylpyrimidine kinase
APT56_RS26990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
APT56_RS26990	COG0352	thiamine-phosphate diphosphorylase activity
APT56_RS27005	COG3210	domain, Protein
APT56_RS27005	COG3210	domain, Protein
APT56_RS27015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
APT56_RS27020	COG0513	Belongs to the DEAD box helicase family
APT56_RS27030	COG0617	tRNA 3'-terminal CCA addition
APT56_RS27040	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APT56_RS27045	COG2308	Evidence 4 Homologs of previously reported genes of
APT56_RS27055	COG1305	Transglutaminase-like
APT56_RS27075	COG1950	PFAM Membrane protein of
APT56_RS27080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APT56_RS27085	COG0438	transferase activity, transferring glycosyl groups
APT56_RS27100	COG0066	3-isopropylmalate dehydratase activity
APT56_RS27110	COG3181	Tripartite tricarboxylate transporter family receptor
APT56_RS27115	COG0583	DNA-binding transcription factor activity
APT56_RS27120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APT56_RS27155	COG0477	Major facilitator Superfamily
APT56_RS27160	COG0154	amidase activity
APT56_RS27165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APT56_RS27175	COG1560	Kdo2-lipid A biosynthetic process
APT56_RS27180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APT56_RS27190	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APT56_RS27195	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
APT56_RS27220	COG0735	belongs to the Fur family
APT56_RS27225	COG0523	cobalamin synthesis protein
APT56_RS27235	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
APT56_RS27240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
APT56_RS27250	COG2096	Adenosyltransferase
APT56_RS27255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APT56_RS27260	COG1609	Transcriptional regulator
APT56_RS27270	COG0321	lipoyl(octanoyl) transferase activity
APT56_RS27275	COG2921	Belongs to the UPF0250 family
APT56_RS27285	COG1686	Belongs to the peptidase S11 family
APT56_RS27310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APT56_RS27320	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APT56_RS27330	COG0859	PFAM glycosyl transferase family 9
APT56_RS27340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APT56_RS27375	COG0438	transferase activity, transferring glycosyl groups
APT56_RS27385	COG2076	Multidrug Resistance protein
APT56_RS27400	COG2814	Major facilitator Superfamily
APT56_RS27430	COG3568	Endonuclease Exonuclease Phosphatase
APT56_RS27435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APT56_RS27460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APT56_RS27475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APT56_RS27480	COG1956	GAF domain-containing protein
APT56_RS27485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APT56_RS27495	COG1422	Protein of unknown function (DUF1090)
APT56_RS27510	COG2186	Transcriptional regulator
APT56_RS27545	COG2226	methyltransferase
APT56_RS27555	COG2814	Major facilitator Superfamily
APT56_RS27565	COG0625	glutathione transferase activity
APT56_RS27570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
APT56_RS27575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APT56_RS27580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APT56_RS27600	COG1965	Belongs to the frataxin family
APT56_RS27610	COG0019	diaminopimelate decarboxylase activity
APT56_RS27615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APT56_RS27620	COG1333	cytochrome c biogenesis protein
APT56_RS27630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
APT56_RS27645	COG4232	protein-disulfide reductase activity
APT56_RS27650	COG1324	tolerance protein
APT56_RS27660	COG0203	ribosomal protein L17
APT56_RS27665	COG0202	RNA polymerase activity
APT56_RS27670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APT56_RS27675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APT56_RS27680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APT56_RS27685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APT56_RS27690	COG0201	protein transport
APT56_RS27695	COG0200	Binds to the 23S rRNA
APT56_RS27700	COG1841	ribosomal large subunit assembly
APT56_RS27705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APT56_RS27710	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APT56_RS27715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APT56_RS27720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APT56_RS27725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APT56_RS27730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APT56_RS27735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APT56_RS27740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APT56_RS27760	COG2207	Transcriptional regulator
APT56_RS27765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
APT56_RS27785	COG4177	L-phenylalanine transmembrane transporter activity
APT56_RS27800	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APT56_RS27805	COG0255	Belongs to the universal ribosomal protein uL29 family
APT56_RS27810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APT56_RS27815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APT56_RS27820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APT56_RS27825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APT56_RS27830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APT56_RS27835	COG0089	rRNA binding
APT56_RS27845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APT56_RS27850	COG0051	transcription antitermination factor activity, RNA binding
APT56_RS27855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
APT56_RS27860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APT56_RS27865	COG0049	tRNA binding
APT56_RS27870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
APT56_RS27875	COG0745	RESPONSE REGULATOR receiver
APT56_RS27890	COG5002	protein histidine kinase activity