locus-tag	class	description
E2544_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E2544_RS00010	COG0592	DNA-directed DNA polymerase activity
E2544_RS00025	COG0583	DNA-binding transcription factor activity
E2544_RS00050	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E2544_RS00070	COG0154	amidase activity
E2544_RS00075	COG1917	Cupin 2, conserved barrel domain protein
E2544_RS00100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2544_RS00130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E2544_RS00140	COG0583	DNA-binding transcription factor activity
E2544_RS00150	COG0765	amino acid transport
E2544_RS00155	COG0765	amino acid transport
E2544_RS00160	COG1126	abc transporter atp-binding protein
E2544_RS00185	COG1304	FMN binding
E2544_RS00200	COG0402	S-adenosylhomocysteine deaminase activity
E2544_RS00210	COG4603	Belongs to the binding-protein-dependent transport system permease family
E2544_RS00215	COG3845	ABC transporter
E2544_RS00220	COG1744	ABC transporter substrate-binding protein PnrA-like
E2544_RS00225	COG0586	Pfam SNARE associated Golgi protein
E2544_RS00230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2544_RS00245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2544_RS00275	COG3781	membrane
E2544_RS00280	COG1522	sequence-specific DNA binding
E2544_RS00285	COG0028	Belongs to the TPP enzyme family
E2544_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS00295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS00300	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E2544_RS00310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E2544_RS00310	COG0551	DNA topoisomerase type I activity
E2544_RS00320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2544_RS00325	COG2922	Belongs to the Smg family
E2544_RS00335	COG2358	TRAP transporter, solute receptor (TAXI family
E2544_RS00375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2544_RS00415	COG3712	iron ion homeostasis
E2544_RS00420	COG1595	DNA-templated transcription, initiation
E2544_RS00435	COG3339	Conserved Protein
E2544_RS00470	COG2814	Major facilitator Superfamily
E2544_RS00500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS00520	COG0583	DNA-binding transcription factor activity
E2544_RS00555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E2544_RS00560	COG0183	Belongs to the thiolase family
E2544_RS00565	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E2544_RS00570	COG1960	acyl-CoA dehydrogenase activity
E2544_RS00575	COG1473	amidohydrolase
E2544_RS00585	COG1742	UPF0060 membrane protein
E2544_RS00600	COG1280	lysine exporter protein (LysE YggA)
E2544_RS00605	COG0778	Nitroreductase
E2544_RS00625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2544_RS00635	COG0018	arginyl-trna synthetase
E2544_RS00650	COG0395	ABC-type sugar transport system, permease component
E2544_RS00655	COG1175	transmembrane transport
E2544_RS00660	COG1653	transport
E2544_RS00665	COG3842	ATPase activity
E2544_RS00670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E2544_RS00675	COG1609	Transcriptional regulator
E2544_RS00680	COG0154	amidase activity
E2544_RS00685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_RS00695	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E2544_RS00705	COG0583	DNA-binding transcription factor activity
E2544_RS00725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E2544_RS00730	COG1280	lysine exporter protein (LysE YggA)
E2544_RS00735	COG0513	Belongs to the DEAD box helicase family
E2544_RS00740	COG5339	Protein conserved in bacteria
E2544_RS00750	COG4172	Belongs to the ABC transporter superfamily
E2544_RS00755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS00760	COG0601	transmembrane transport
E2544_RS00765	COG0747	negative chemotaxis
E2544_RS00770	COG1160	GTP binding
E2544_RS00780	COG2207	Transcriptional regulator
E2544_RS00780	COG3708	Transcriptional regulator
E2544_RS00790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E2544_RS00800	COG0583	DNA-binding transcription factor activity
E2544_RS00810	COG1414	Transcriptional regulator
E2544_RS00815	COG0154	amidase activity
E2544_RS00830	COG2969	positive regulation of protein catabolic process
E2544_RS00835	COG0625	glutathione transferase activity
E2544_RS00840	COG2857	Cytochrome c1
E2544_RS00845	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E2544_RS00850	COG0723	plastoquinol--plastocyanin reductase activity
E2544_RS00855	COG1970	mechanosensitive ion channel activity
E2544_RS00860	COG0235	Class ii aldolase
E2544_RS00870	COG0477	Major facilitator Superfamily
E2544_RS00880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E2544_RS00885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2544_RS00900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2544_RS00905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E2544_RS00910	COG0537	adenosine 5'-monophosphoramidase activity
E2544_RS00915	COG0140	phosphoribosyl-ATP diphosphatase activity
E2544_RS00925	COG0107	imidazoleglycerol-phosphate synthase activity
E2544_RS00930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E2544_RS00935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E2544_RS00940	COG0131	Imidazoleglycerol-phosphate dehydratase
E2544_RS00945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2544_RS00950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E2544_RS00960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E2544_RS00970	COG0842	Transport permease protein
E2544_RS00975	COG1131	(ABC) transporter
E2544_RS00985	COG2853	Lipoprotein
E2544_RS00990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E2544_RS00995	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2544_RS01000	COG1127	ABC transporter
E2544_RS01015	COG0477	Major facilitator Superfamily
E2544_RS01020	COG0583	DNA-binding transcription factor activity
E2544_RS01035	COG0069	glutamate synthase activity
E2544_RS01035	COG0070	glutamate synthase
E2544_RS01035	COG0067	glutamate synthase
E2544_RS01060	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E2544_RS01080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2544_RS01110	COG1612	heme a metabolic process
E2544_RS01120	COG1999	signal sequence binding
E2544_RS01140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E2544_RS01145	COG2814	Major facilitator Superfamily
E2544_RS01160	COG1522	sequence-specific DNA binding
E2544_RS01175	COG0457	Tetratricopeptide repeat
E2544_RS01180	COG0438	transferase activity, transferring glycosyl groups
E2544_RS01205	COG4783	chaperone-mediated protein folding
E2544_RS01205	COG1560	Kdo2-lipid A biosynthetic process
E2544_RS01210	COG3866	Pectate lyase
E2544_RS01220	COG3550	peptidyl-serine autophosphorylation
E2544_RS01230	COG2814	Major facilitator Superfamily
E2544_RS01245	COG3246	L-lysine catabolic process to acetate
E2544_RS01255	COG0861	Integral membrane protein TerC family
E2544_RS01295	COG1956	GAF domain-containing protein
E2544_RS01305	COG0656	L-ascorbic acid biosynthetic process
E2544_RS01315	COG2423	ornithine cyclodeaminase activity
E2544_RS01325	COG1522	sequence-specific DNA binding
E2544_RS01330	COG2423	ornithine cyclodeaminase activity
E2544_RS01340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E2544_RS01345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E2544_RS01355	COG0438	transferase activity, transferring glycosyl groups
E2544_RS01360	COG0737	Belongs to the 5'-nucleotidase family
E2544_RS01390	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E2544_RS01405	COG2814	Major facilitator Superfamily
E2544_RS01410	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS01415	COG0583	DNA-binding transcription factor activity
E2544_RS01420	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS01425	COG1473	amidohydrolase
E2544_RS01430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E2544_RS01480	COG1802	Transcriptional regulator
E2544_RS01490	COG3069	C4-dicarboxylate transmembrane transporter activity
E2544_RS01505	COG0543	2 iron, 2 sulfur cluster binding
E2544_RS01505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2544_RS01515	COG0431	NADPH-dependent FMN reductase
E2544_RS01520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS01525	COG1116	anion transmembrane transporter activity
E2544_RS01530	COG3585	molybdate ion transport
E2544_RS01535	COG3064	Membrane
E2544_RS01560	COG1607	acyl-coa hydrolase
E2544_RS01575	COG0437	4 iron, 4 sulfur cluster binding
E2544_RS01580	COG2864	formate dehydrogenase
E2544_RS01595	COG3276	selenocysteine insertion sequence binding
E2544_RS01610	COG1305	Transglutaminase-like
E2544_RS01615	COG0709	Synthesizes selenophosphate from selenide and ATP
E2544_RS01640	COG1012	belongs to the aldehyde dehydrogenase family
E2544_RS01645	COG3284	Transcriptional regulator
E2544_RS01650	COG0134	indole-3-glycerol-phosphate synthase activity
E2544_RS01660	COG0512	Glutamine amidotransferase of anthranilate synthase
E2544_RS01670	COG0546	phosphoglycolate phosphatase activity
E2544_RS01675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E2544_RS01680	COG2967	ApaG domain
E2544_RS01685	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E2544_RS01690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_RS01700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_RS01705	COG0037	tRNA processing
E2544_RS01730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2544_RS01740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2544_RS01745	COG0583	DNA-binding transcription factor activity
E2544_RS01750	COG0683	leucine binding
E2544_RS01755	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_RS01775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2544_RS01800	COG3473	Maleate cis-trans isomerase
E2544_RS01815	COG1024	Enoyl-CoA hydratase
E2544_RS01830	COG0356	it plays a direct role in the translocation of protons across the membrane
E2544_RS01845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E2544_RS01850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E2544_RS01855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E2544_RS01865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E2544_RS01875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E2544_RS01880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E2544_RS01885	COG0210	DNA helicase
E2544_RS01890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2544_RS01900	COG2171	N-acyltransferase activity
E2544_RS01915	COG2195	Cleaves the N-terminal amino acid of tripeptides
E2544_RS01925	COG4608	Belongs to the ABC transporter superfamily
E2544_RS01930	COG0444	Belongs to the ABC transporter superfamily
E2544_RS01940	COG0601	transmembrane transport
E2544_RS01945	COG4166	transmembrane transport
E2544_RS01950	COG2988	succinylglutamate desuccinylase activity
E2544_RS01955	COG0583	DNA-binding transcription factor activity
E2544_RS01960	COG0747	negative chemotaxis
E2544_RS01970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E2544_RS01975	COG1024	Enoyl-CoA hydratase
E2544_RS01980	COG1024	Enoyl-CoA hydratase
E2544_RS01990	COG1309	transcriptional regulator
E2544_RS02000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS02005	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_RS02020	COG0523	cobalamin synthesis protein
E2544_RS02050	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS02065	COG2205	protein histidine kinase activity
E2544_RS02065	COG0784	Response regulator, receiver
E2544_RS02070	COG2197	response regulator
E2544_RS02110	COG1764	response to oxidative stress
E2544_RS02115	COG0583	DNA-binding transcription factor activity
E2544_RS02125	COG1595	DNA-templated transcription, initiation
E2544_RS02135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2544_RS02185	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2544_RS02215	COG1802	Transcriptional regulator
E2544_RS02225	COG0583	DNA-binding transcription factor activity
E2544_RS02245	COG2918	glutathione biosynthetic process
E2544_RS02270	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E2544_RS02275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_RS02285	COG2721	sulfolactate sulfo-lyase activity
E2544_RS02290	COG2721	sulfolactate sulfo-lyase activity
E2544_RS02295	COG2188	Transcriptional regulator
E2544_RS02300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2544_RS02305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2544_RS02305	COG2813	Specifically methylates the guanine in position
E2544_RS02310	COG2223	nitrite transmembrane transporter activity
E2544_RS02320	COG2860	membrane
E2544_RS02325	COG1802	Transcriptional regulator
E2544_RS02335	COG1984	allophanate hydrolase subunit 2
E2544_RS02340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E2544_RS02350	COG0583	DNA-binding transcription factor activity
E2544_RS02355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_RS02375	COG5002	protein histidine kinase activity
E2544_RS02380	COG0745	RESPONSE REGULATOR receiver
E2544_RS02385	COG2226	methyltransferase
E2544_RS02400	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E2544_RS02410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2544_RS02420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2544_RS02425	COG0351	phosphomethylpyrimidine kinase
E2544_RS02430	COG2022	thiamine diphosphate biosynthetic process
E2544_RS02435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E2544_RS02440	COG4771	TonB-dependent receptor
E2544_RS02460	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS02490	COG0583	DNA-binding transcription factor activity
E2544_RS02505	COG0625	glutathione transferase activity
E2544_RS02510	COG1053	succinate dehydrogenase
E2544_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS02520	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS02540	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_RS02550	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS02555	COG1802	Transcriptional regulator
E2544_RS02560	COG0288	reversible hydration of carbon dioxide
E2544_RS02580	COG2226	methyltransferase
E2544_RS02590	COG1802	Transcriptional regulator
E2544_RS02595	COG0028	Belongs to the TPP enzyme family
E2544_RS02610	COG1194	a g-specific adenine glycosylase
E2544_RS02620	COG0583	DNA-binding transcription factor activity
E2544_RS02625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2544_RS02630	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_RS02640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E2544_RS02645	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS02675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E2544_RS02685	COG2186	Transcriptional regulator
E2544_RS02695	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
E2544_RS02710	COG2177	Part of the ABC transporter FtsEX involved in
E2544_RS02715	COG2884	Cell division ATP-binding protein ftsE
E2544_RS02720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS02725	COG4597	amino acid ABC transporter
E2544_RS02730	COG0765	amino acid transport
E2544_RS02735	COG1126	abc transporter atp-binding protein
E2544_RS02755	COG1129	ABC transporter
E2544_RS02760	COG4177	L-phenylalanine transmembrane transporter activity
E2544_RS02775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_RS02780	COG2081	HI0933 family
E2544_RS02785	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS02790	COG1605	Chorismate mutase
E2544_RS02790	COG0077	Prephenate dehydratase
E2544_RS02795	COG0625	glutathione transferase activity
E2544_RS02830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_RS02835	COG0583	DNA-binding transcription factor activity
E2544_RS02840	COG0628	permease
E2544_RS02850	COG0477	Major facilitator Superfamily
E2544_RS02865	COG1695	Transcriptional regulator
E2544_RS02875	COG0583	DNA-binding transcription factor activity
E2544_RS02920	COG0583	DNA-binding transcription factor activity
E2544_RS02925	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS02935	COG3246	L-lysine catabolic process to acetate
E2544_RS02940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E2544_RS02945	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2544_RS02960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_RS02970	COG0583	DNA-binding transcription factor activity
E2544_RS02975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2544_RS02995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS03000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E2544_RS03000	COG2010	Cytochrome c
E2544_RS03005	COG1335	isochorismatase
E2544_RS03010	COG2309	aminopeptidase activity
E2544_RS03015	COG0596	Alpha beta hydrolase
E2544_RS03025	COG2080	2 iron, 2 sulfur cluster binding
E2544_RS03030	COG2010	Cytochrome c
E2544_RS03030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E2544_RS03035	COG0477	Major facilitator Superfamily
E2544_RS03040	COG1846	Transcriptional regulator
E2544_RS03070	COG4221	oxidoreductase activity
E2544_RS03155	COG2233	PERMEase
E2544_RS03165	COG0326	Molecular chaperone. Has ATPase activity
E2544_RS03175	COG0604	alcohol dehydrogenase
E2544_RS03205	COG2814	Major facilitator Superfamily
E2544_RS03215	COG1473	amidohydrolase
E2544_RS03220	COG2271	Major facilitator Superfamily
E2544_RS03225	COG4948	Mandelate Racemase Muconate Lactonizing
E2544_RS03230	COG0800	Aldolase
E2544_RS03235	COG3734	2-keto-3-deoxy-galactonokinase
E2544_RS03240	COG1414	Transcriptional regulator
E2544_RS03245	COG0625	glutathione transferase activity
E2544_RS03260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2544_RS03265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E2544_RS03275	COG1652	LysM domain
E2544_RS03295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E2544_RS03305	COG1295	ribonuclease BN
E2544_RS03315	COG2124	cytochrome p450
E2544_RS03345	COG0459	protein refolding
E2544_RS03350	COG2207	Transcriptional regulator
E2544_RS03355	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS03400	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E2544_RS03415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_RS03420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2544_RS03450	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E2544_RS03490	COG2828	Protein conserved in bacteria
E2544_RS03495	COG0583	DNA-binding transcription factor activity
E2544_RS03505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2544_RS03520	COG1448	Aminotransferase
E2544_RS03525	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2544_RS03545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E2544_RS03610	COG3275	phosphorelay sensor kinase activity
E2544_RS03615	COG1522	sequence-specific DNA binding
E2544_RS03630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2544_RS03635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS03640	COG0006	proline dipeptidase activity
E2544_RS03685	COG0505	Belongs to the CarA family
E2544_RS03695	COG0477	Major facilitator Superfamily
E2544_RS03705	COG1802	Transcriptional regulator
E2544_RS03720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_RS03730	COG0583	DNA-binding transcription factor activity
E2544_RS03735	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E2544_RS03750	COG3135	benzoate transporter
E2544_RS03760	COG2072	flavoprotein involved in K transport
E2544_RS03765	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS03770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2544_RS03785	COG0583	DNA-binding transcription factor activity
E2544_RS03790	COG0165	Argininosuccinate lyase
E2544_RS03805	COG2132	Multicopper oxidase
E2544_RS03870	COG3210	domain, Protein
E2544_RS03895	COG3284	Transcriptional regulator
E2544_RS03905	COG2267	carboxylic ester hydrolase activity
E2544_RS03915	COG0583	DNA-binding transcription factor activity
E2544_RS03920	COG0583	DNA-binding transcription factor activity
E2544_RS04125	COG0625	glutathione transferase activity
E2544_RS04130	COG0583	DNA-binding transcription factor activity
E2544_RS04135	COG1053	succinate dehydrogenase
E2544_RS04135	COG3976	FMN-binding domain protein
E2544_RS04150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_RS04160	COG1294	oxidase, subunit
E2544_RS04165	COG1271	oxidase subunit
E2544_RS04170	COG0697	spore germination
E2544_RS04190	COG0842	Transport permease protein
E2544_RS04195	COG0842	Transport permease protein
E2544_RS04195	COG1129	ABC transporter
E2544_RS04200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_RS04215	COG2200	EAL domain
E2544_RS04220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E2544_RS04225	COG0745	RESPONSE REGULATOR receiver
E2544_RS04235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E2544_RS04235	COG2755	lipolytic protein G-D-S-L family
E2544_RS04250	COG1054	Belongs to the UPF0176 family
E2544_RS04255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2544_RS04255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2544_RS04265	COG0489	protein tyrosine kinase activity
E2544_RS04280	COG0717	Belongs to the dCTP deaminase family
E2544_RS04290	COG2199	diguanylate cyclase activity
E2544_RS04310	COG2081	HI0933 family
E2544_RS04325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E2544_RS04330	COG0509	glycine decarboxylation via glycine cleavage system
E2544_RS04335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2544_RS04335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E2544_RS04350	COG0154	amidase activity
E2544_RS04355	COG4172	Belongs to the ABC transporter superfamily
E2544_RS04360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS04365	COG0601	transmembrane transport
E2544_RS04385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2544_RS04390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_RS04415	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E2544_RS04420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2544_RS04425	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E2544_RS04440	COG0438	transferase activity, transferring glycosyl groups
E2544_RS04450	COG0438	transferase activity, transferring glycosyl groups
E2544_RS04455	COG0438	transferase activity, transferring glycosyl groups
E2544_RS04460	COG0438	transferase activity, transferring glycosyl groups
E2544_RS04465	COG0166	Belongs to the GPI family
E2544_RS04480	COG0277	FAD linked oxidase domain protein
E2544_RS04485	COG0745	RESPONSE REGULATOR receiver
E2544_RS04490	COG0642	Histidine kinase
E2544_RS04500	COG2186	Transcriptional regulator
E2544_RS04505	COG1368	sulfuric ester hydrolase activity
E2544_RS04510	COG0204	Acyl-transferase
E2544_RS04535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_RS04545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E2544_RS04560	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E2544_RS04590	COG0012	GTP binding
E2544_RS04600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_RS04605	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS04610	COG0473	3-isopropylmalate dehydrogenase activity
E2544_RS04610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_RS04625	COG2814	Major facilitator Superfamily
E2544_RS04640	COG3135	benzoate transporter
E2544_RS04645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2544_RS04650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E2544_RS04655	COG0742	ribosomal rna small subunit methyltransferase
E2544_RS04675	COG3639	organic phosphonate transmembrane transporter activity
E2544_RS04680	COG3639	organic phosphonate transmembrane transporter activity
E2544_RS04685	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2544_RS04710	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E2544_RS04715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2544_RS04725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E2544_RS04730	COG1546	Belongs to the CinA family
E2544_RS04735	COG0284	orotidine-5'-phosphate decarboxylase activity
E2544_RS04740	COG1252	NADH dehydrogenase
E2544_RS04745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E2544_RS04755	COG1063	alcohol dehydrogenase
E2544_RS04760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_RS04770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_RS04775	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS04785	COG2721	sulfolactate sulfo-lyase activity
E2544_RS04790	COG4948	Mandelate Racemase Muconate Lactonizing
E2544_RS04795	COG0246	Mannitol dehydrogenase
E2544_RS04800	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E2544_RS04810	COG1917	Cupin 2, conserved barrel domain protein
E2544_RS04830	COG1846	Transcriptional regulator
E2544_RS04840	COG0459	protein refolding
E2544_RS04845	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E2544_RS04870	COG0583	DNA-binding transcription factor activity
E2544_RS04875	COG3618	amidohydrolase
E2544_RS04880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS04900	COG2084	Dehydrogenase
E2544_RS04905	COG1304	FMN binding
E2544_RS04915	COG0697	spore germination
E2544_RS04935	COG0500	methyltransferase
E2544_RS04945	COG0693	protein deglycase activity
E2544_RS04975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS05030	COG3618	amidohydrolase
E2544_RS05035	COG0473	3-isopropylmalate dehydrogenase activity
E2544_RS05045	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS05050	COG1802	Transcriptional regulator
E2544_RS05055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E2544_RS05060	COG0583	DNA-binding transcription factor activity
E2544_RS05070	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS05075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_RS05085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2544_RS05110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_RS05115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_RS05135	COG0583	DNA-binding transcription factor activity
E2544_RS05175	COG1595	DNA-templated transcription, initiation
E2544_RS05185	COG1024	Enoyl-CoA hydratase
E2544_RS05205	COG0444	Belongs to the ABC transporter superfamily
E2544_RS05215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS05225	COG1024	Enoyl-CoA hydratase
E2544_RS05255	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS05260	COG1802	Transcriptional regulator
E2544_RS05270	COG0247	lactate metabolic process
E2544_RS05280	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS05285	COG0596	Alpha beta hydrolase
E2544_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS05300	COG1309	transcriptional regulator
E2544_RS05320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_RS05325	COG0583	DNA-binding transcription factor activity
E2544_RS05330	COG1522	sequence-specific DNA binding
E2544_RS05335	COG0626	cystathionine gamma-synthase activity
E2544_RS05340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_RS05345	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS05420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS05425	COG1301	dicarboxylic acid transport
E2544_RS05470	COG4774	siderophore transport
E2544_RS05495	COG1733	regulation of RNA biosynthetic process
E2544_RS05505	COG0668	transmembrane transport
E2544_RS05535	COG2249	NAD(P)H dehydrogenase (quinone) activity
E2544_RS05540	COG1802	Transcriptional regulator
E2544_RS05545	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2544_RS05550	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS05565	COG1960	acyl-CoA dehydrogenase activity
E2544_RS05585	COG1454	alcohol dehydrogenase
E2544_RS05590	COG1012	belongs to the aldehyde dehydrogenase family
E2544_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS05605	COG1012	belongs to the aldehyde dehydrogenase family
E2544_RS05605	COG2030	dehydratase
E2544_RS05635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2544_RS05640	COG0625	glutathione transferase activity
E2544_RS05655	COG2130	NADP-dependent
E2544_RS05660	COG2030	dehydratase
E2544_RS05670	COG3246	L-lysine catabolic process to acetate
E2544_RS05685	COG2301	Belongs to the HpcH HpaI aldolase family
E2544_RS05695	COG0154	amidase activity
E2544_RS05700	COG4608	Belongs to the ABC transporter superfamily
E2544_RS05705	COG0444	Belongs to the ABC transporter superfamily
E2544_RS05710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS05715	COG0601	transmembrane transport
E2544_RS05720	COG0747	negative chemotaxis
E2544_RS05755	COG2375	cellular response to nickel ion
E2544_RS05755	COG1132	(ABC) transporter
E2544_RS05760	COG1132	(ABC) transporter
E2544_RS05765	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2544_RS05770	COG4605	iron ion homeostasis
E2544_RS05775	COG4604	ABC transporter, ATP-binding protein
E2544_RS05780	COG4607	ABC-type enterochelin transport system periplasmic component
E2544_RS05785	COG4774	siderophore transport
E2544_RS05790	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E2544_RS05795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E2544_RS05800	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
E2544_RS05825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E2544_RS05845	COG0133	tryptophan synthase activity
E2544_RS05885	COG1280	lysine exporter protein (LysE YggA)
E2544_RS05895	COG1024	Enoyl-CoA hydratase
E2544_RS05900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS05925	COG2188	Transcriptional regulator
E2544_RS05945	COG2837	iron assimilation
E2544_RS05960	COG0667	Aldo Keto reductase
E2544_RS05965	COG3795	YCII-related domain
E2544_RS05985	COG0519	Catalyzes the synthesis of GMP from XMP
E2544_RS06005	COG0625	glutathione transferase activity
E2544_RS06015	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_RS06025	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E2544_RS06030	COG1845	cytochrome c oxidase, subunit III
E2544_RS06035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2544_RS06040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E2544_RS06045	COG0477	Major facilitator Superfamily
E2544_RS06050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS06055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2544_RS06090	COG0583	DNA-binding transcription factor activity
E2544_RS06095	COG0861	Integral membrane protein TerC family
E2544_RS06100	COG4106	trans-aconitate 2-methyltransferase activity
E2544_RS06115	COG2207	Transcriptional regulator
E2544_RS06120	COG2807	transmembrane transport
E2544_RS06135	COG0330	HflC and HflK could
E2544_RS06140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E2544_RS06150	COG1595	DNA-templated transcription, initiation
E2544_RS06155	COG3712	iron ion homeostasis
E2544_RS06175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2544_RS06180	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS06185	COG1285	pathogenesis
E2544_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS06205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2544_RS06215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2544_RS06220	COG1396	sequence-specific DNA binding
E2544_RS06225	COG0456	acetyltransferase
E2544_RS06265	COG0697	spore germination
E2544_RS06290	COG0280	phosphate acetyltransferase
E2544_RS06290	COG0281	malic enzyme
E2544_RS06310	COG4772	TonB-dependent receptor
E2544_RS06325	COG1845	cytochrome c oxidase, subunit III
E2544_RS06330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2544_RS06340	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E2544_RS06360	COG1999	signal sequence binding
E2544_RS06375	COG1126	abc transporter atp-binding protein
E2544_RS06380	COG0765	amino acid transport
E2544_RS06385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS06390	COG3191	aminopeptidase activity
E2544_RS06395	COG1272	protein, Hemolysin III
E2544_RS06400	COG1522	sequence-specific DNA binding
E2544_RS06410	COG1113	amino acid transport
E2544_RS06420	COG2378	regulation of single-species biofilm formation
E2544_RS06450	COG1595	DNA-templated transcription, initiation
E2544_RS06465	COG3720	iron ion transport
E2544_RS06470	COG4558	Periplasmic binding protein
E2544_RS06475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2544_RS06480	COG1120	ATPase activity
E2544_RS06485	COG1666	GTP binding
E2544_RS06495	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E2544_RS06520	COG0671	phosphoesterase, PA-phosphatase related
E2544_RS06600	COG0456	acetyltransferase
E2544_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS06620	COG0251	oxidation-reduction process
E2544_RS06660	COG0683	leucine binding
E2544_RS06665	COG2188	Transcriptional regulator
E2544_RS06675	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS06690	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS06700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2544_RS06735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E2544_RS06740	COG0583	DNA-binding transcription factor activity
E2544_RS06770	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E2544_RS06775	COG3383	formate dehydrogenase (NAD+) activity
E2544_RS06785	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E2544_RS06795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E2544_RS06800	COG0746	molybdenum cofactor guanylyltransferase activity
E2544_RS06805	COG0303	'Molybdopterin
E2544_RS06810	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2544_RS06825	COG0315	cyclic pyranopterin monophosphate synthase activity
E2544_RS06835	COG0412	Dienelactone hydrolase
E2544_RS06845	COG0678	peroxiredoxin activity
E2544_RS06855	COG0697	spore germination
E2544_RS06865	COG4191	Histidine kinase
E2544_RS06900	COG0667	Aldo Keto reductase
E2544_RS06905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E2544_RS06910	COG4535	Mg2 and Co2 transporter CorC
E2544_RS06915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E2544_RS06920	COG1702	phosphate starvation-inducible protein PhoH
E2544_RS06925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2544_RS06935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2544_RS06945	COG0740	serine-type endopeptidase activity
E2544_RS06955	COG0640	Transcriptional regulator
E2544_RS06960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2544_RS06965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2544_RS06970	COG1862	Preprotein translocase
E2544_RS06975	COG0343	queuine tRNA-ribosyltransferase activity
E2544_RS06980	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E2544_RS07000	COG2027	D-alanyl-D-alanine carboxypeptidase
E2544_RS07005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E2544_RS07010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2544_RS07010	COG1648	precorrin-2 dehydrogenase activity
E2544_RS07020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2544_RS07025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS07030	COG1116	anion transmembrane transporter activity
E2544_RS07035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2544_RS07040	COG0243	molybdopterin cofactor binding
E2544_RS07050	COG4575	ribosome binding
E2544_RS07065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E2544_RS07070	COG0741	lytic transglycosylase activity
E2544_RS07075	COG0436	Aminotransferase
E2544_RS07085	COG0281	malic enzyme
E2544_RS07085	COG0280	phosphate acetyltransferase
E2544_RS07095	COG2732	(Barnase) inhibitor
E2544_RS07100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E2544_RS07105	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E2544_RS07110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2544_RS07115	COG0126	phosphoglycerate kinase activity
E2544_RS07130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E2544_RS07135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E2544_RS07155	COG0625	glutathione transferase activity
E2544_RS07195	COG0306	phosphate transporter
E2544_RS07205	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2544_RS07215	COG0739	heme binding
E2544_RS07225	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E2544_RS07245	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2544_RS07250	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E2544_RS07255	COG3639	organic phosphonate transmembrane transporter activity
E2544_RS07270	COG0405	Gamma-glutamyltransferase
E2544_RS07275	COG0583	DNA-binding transcription factor activity
E2544_RS07280	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E2544_RS07285	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E2544_RS07290	COG3454	Phosphonate metabolism
E2544_RS07295	COG2188	Transcriptional regulator
E2544_RS07300	COG3624	Phosphonate C-P lyase system protein PhnG
E2544_RS07310	COG3626	phosphonate metabolism
E2544_RS07315	COG3627	carbon phosphorus lyase activity
E2544_RS07320	COG4107	phosphonate C-P lyase system protein PhnK
E2544_RS07325	COG4778	phosphonate C-P lyase system protein PhnL
E2544_RS07330	COG3454	Phosphonate metabolism
E2544_RS07350	COG1301	dicarboxylic acid transport
E2544_RS07370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E2544_RS07375	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E2544_RS07380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E2544_RS07385	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E2544_RS07390	COG0009	L-threonylcarbamoyladenylate synthase
E2544_RS07395	COG1414	Transcriptional regulator
E2544_RS07400	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2544_RS07410	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS07415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS07420	COG1414	Transcriptional regulator
E2544_RS07425	COG0010	Belongs to the arginase family
E2544_RS07430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS07435	COG0765	amino acid transport
E2544_RS07440	COG1126	abc transporter atp-binding protein
E2544_RS07445	COG0028	Belongs to the TPP enzyme family
E2544_RS07490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E2544_RS07510	COG2030	dehydratase
E2544_RS07515	COG2814	Major facilitator Superfamily
E2544_RS07520	COG0583	DNA-binding transcription factor activity
E2544_RS07535	COG1960	acyl-CoA dehydrogenase activity
E2544_RS07540	COG0028	Belongs to the TPP enzyme family
E2544_RS07545	COG0583	DNA-binding transcription factor activity
E2544_RS07550	COG4974	Belongs to the 'phage' integrase family
E2544_RS07555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E2544_RS07560	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E2544_RS07575	COG1686	Belongs to the peptidase S11 family
E2544_RS07600	COG1074	ATP-dependent DNA helicase activity
E2544_RS07610	COG3842	ATPase activity
E2544_RS07615	COG1840	ABC-type Fe3 transport system, periplasmic component
E2544_RS07625	COG1177	transmembrane transport
E2544_RS07640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_RS07655	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E2544_RS07670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS07675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2544_RS07685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS07705	COG0583	DNA-binding transcription factor activity
E2544_RS07710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E2544_RS07715	COG0505	Belongs to the CarA family
E2544_RS07720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E2544_RS07730	COG0406	alpha-ribazole phosphatase activity
E2544_RS07735	COG0583	DNA-binding transcription factor activity
E2544_RS07740	COG3842	ATPase activity
E2544_RS07760	COG2233	PERMEase
E2544_RS07765	COG0840	transmembrane signaling receptor activity
E2544_RS07770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2544_RS07775	COG1534	Rna-binding protein
E2544_RS07780	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E2544_RS07785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2544_RS07795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E2544_RS07830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E2544_RS07845	COG1278	Cold shock
E2544_RS07855	COG1418	mRNA catabolic process
E2544_RS07860	COG1960	acyl-CoA dehydrogenase activity
E2544_RS07865	COG2030	dehydratase
E2544_RS07885	COG1024	Enoyl-CoA hydratase
E2544_RS07890	COG1960	acyl-CoA dehydrogenase activity
E2544_RS07905	COG1024	Enoyl-CoA hydratase
E2544_RS07925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E2544_RS07930	COG0022	dehydrogenase e1 component
E2544_RS07935	COG1024	Enoyl-CoA hydratase
E2544_RS07960	COG0683	leucine binding
E2544_RS07965	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_RS07980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2544_RS08010	COG1335	isochorismatase
E2544_RS08020	COG0583	DNA-binding transcription factor activity
E2544_RS08030	COG1609	Transcriptional regulator
E2544_RS08040	COG0251	oxidation-reduction process
E2544_RS08060	COG0765	amino acid transport
E2544_RS08070	COG2207	Transcriptional regulator
E2544_RS08075	COG0667	Aldo Keto reductase
E2544_RS08085	COG0500	methyltransferase
E2544_RS08090	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS08095	COG0604	alcohol dehydrogenase
E2544_RS08095	COG3321	synthase
E2544_RS08095	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS08110	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_RS08120	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS08125	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_RS08130	COG3246	L-lysine catabolic process to acetate
E2544_RS08135	COG0371	Dehydrogenase
E2544_RS08140	COG1802	Transcriptional regulator
E2544_RS08145	COG3959	Transketolase, thiamine diphosphate binding domain
E2544_RS08150	COG3958	Transketolase
E2544_RS08155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E2544_RS08165	COG3938	Belongs to the proline racemase family
E2544_RS08170	COG1177	transmembrane transport
E2544_RS08175	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2544_RS08180	COG3842	ATPase activity
E2544_RS08235	COG1511	domain protein
E2544_RS08235	COG3264	Mechanosensitive ion channel
E2544_RS08240	COG0583	DNA-binding transcription factor activity
E2544_RS08245	COG0427	acetyl-CoA hydrolase
E2544_RS08250	COG0583	DNA-binding transcription factor activity
E2544_RS08285	COG0583	DNA-binding transcription factor activity
E2544_RS08300	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_RS08310	COG0477	Major facilitator Superfamily
E2544_RS08320	COG0154	amidase activity
E2544_RS08340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E2544_RS08355	COG0495	leucyl-tRNA aminoacylation
E2544_RS08360	COG2814	Major facilitator Superfamily
E2544_RS08365	COG1846	Transcriptional regulator
E2544_RS08375	COG1686	Belongs to the peptidase S11 family
E2544_RS08410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E2544_RS08415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E2544_RS08420	COG2814	Major facilitator Superfamily
E2544_RS08425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2544_RS08435	COG4176	ABC-type proline glycine betaine transport system permease component
E2544_RS08440	COG3448	diguanylate cyclase activity
E2544_RS08440	COG4175	Glycine betaine
E2544_RS08450	COG0583	DNA-binding transcription factor activity
E2544_RS08455	COG0243	molybdopterin cofactor binding
E2544_RS08460	COG3781	membrane
E2544_RS08490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS08490	COG2205	protein histidine kinase activity
E2544_RS08500	COG2197	response regulator
E2544_RS08505	COG0784	Response regulator, receiver
E2544_RS08505	COG2205	protein histidine kinase activity
E2544_RS08515	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS08530	COG1396	sequence-specific DNA binding
E2544_RS08550	COG1012	belongs to the aldehyde dehydrogenase family
E2544_RS08570	COG0765	amino acid transport
E2544_RS08575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_RS08640	COG1278	Cold shock
E2544_RS08785	COG0740	serine-type endopeptidase activity
E2544_RS08830	COG1196	nuclear chromosome segregation
E2544_RS08940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_RS08955	COG0438	transferase activity, transferring glycosyl groups
E2544_RS08985	COG5265	(ABC) transporter
E2544_RS08995	COG0438	transferase activity, transferring glycosyl groups
E2544_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS09005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2544_RS09015	COG2192	nodulation
E2544_RS09065	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E2544_RS09065	COG2010	Cytochrome c
E2544_RS09070	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2544_RS09090	COG0166	Belongs to the GPI family
E2544_RS09095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2544_RS09100	COG0668	transmembrane transport
E2544_RS09120	COG1546	Belongs to the CinA family
E2544_RS09120	COG1058	Belongs to the CinA family
E2544_RS09135	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS09150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_RS09175	COG0028	Belongs to the TPP enzyme family
E2544_RS09195	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS09245	COG1802	Transcriptional regulator
E2544_RS09275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2544_RS09290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_RS09300	COG0633	Ferredoxin
E2544_RS09305	COG0789	Transcriptional regulator
E2544_RS09335	COG2204	response regulator
E2544_RS09340	COG4191	Histidine kinase
E2544_RS09340	COG0784	Response regulator, receiver
E2544_RS09355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E2544_RS09365	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS09375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_RS09385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_RS09395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_RS09400	COG0583	DNA-binding transcription factor activity
E2544_RS09420	COG2808	Putative FMN-binding domain
E2544_RS09430	COG0640	Transcriptional regulator
E2544_RS09450	COG2321	neutral zinc metallopeptidase
E2544_RS09455	COG0009	L-threonylcarbamoyladenylate synthase
E2544_RS09460	COG1994	Peptidase M50
E2544_RS09465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_RS09470	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E2544_RS09480	COG2850	peptidyl-arginine hydroxylation
E2544_RS09500	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS09505	COG0583	DNA-binding transcription factor activity
E2544_RS09530	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS09535	COG0583	DNA-binding transcription factor activity
E2544_RS09545	COG3360	Dodecin
E2544_RS09565	COG1802	Transcriptional regulator
E2544_RS09585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS09590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2544_RS09610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_RS09620	COG0235	Class ii aldolase
E2544_RS09650	COG0668	transmembrane transport
E2544_RS09670	COG0483	inositol monophosphate 1-phosphatase activity
E2544_RS09680	COG1253	flavin adenine dinucleotide binding
E2544_RS09685	COG1968	undecaprenyl-diphosphatase activity
E2544_RS09690	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2544_RS09705	COG0215	cysteine-tRNA ligase activity
E2544_RS09715	COG0825	malonyl-CoA metabolic process
E2544_RS09720	COG0037	tRNA processing
E2544_RS09725	COG0527	aspartate kinase activity
E2544_RS09735	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E2544_RS09750	COG1414	Transcriptional regulator
E2544_RS09805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E2544_RS09815	COG1414	Transcriptional regulator
E2544_RS09825	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS09835	COG1024	Enoyl-CoA hydratase
E2544_RS09840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E2544_RS09845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2544_RS09850	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS09860	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2544_RS09865	COG2186	Transcriptional regulator
E2544_RS09875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E2544_RS09880	COG3395	kinase activity
E2544_RS09890	COG4774	siderophore transport
E2544_RS09900	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS09910	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS09925	COG0183	Belongs to the thiolase family
E2544_RS09930	COG1024	Enoyl-CoA hydratase
E2544_RS09930	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_RS09940	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_RS09940	COG1024	Enoyl-CoA hydratase
E2544_RS09945	COG0183	Belongs to the thiolase family
E2544_RS09950	COG1960	acyl-CoA dehydrogenase activity
E2544_RS09955	COG1309	transcriptional regulator
E2544_RS09965	COG2197	response regulator
E2544_RS09970	COG2197	response regulator
E2544_RS09975	COG0297	glycogen (starch) synthase activity
E2544_RS09980	COG0110	maltose O-acetyltransferase activity
E2544_RS09990	COG0438	transferase activity, transferring glycosyl groups
E2544_RS10010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2544_RS10055	COG0166	Belongs to the GPI family
E2544_RS10060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2544_RS10065	COG1045	serine acetyltransferase
E2544_RS10070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E2544_RS10085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2544_RS10105	COG0598	Magnesium transport protein CorA
E2544_RS10120	COG0601	transmembrane transport
E2544_RS10125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS10130	COG4172	Belongs to the ABC transporter superfamily
E2544_RS10135	COG1846	Transcriptional regulator
E2544_RS10180	COG4964	Belongs to the GSP D family
E2544_RS10240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E2544_RS10255	COG3384	dioxygenase
E2544_RS10260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E2544_RS10270	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS10275	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS10285	COG1802	Transcriptional regulator
E2544_RS10355	COG0516	GMP reductase activity
E2544_RS10355	COG0517	IMP dehydrogenase activity
E2544_RS10360	COG0583	DNA-binding transcription factor activity
E2544_RS10365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS10375	COG1960	acyl-CoA dehydrogenase activity
E2544_RS10380	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS10385	COG1024	Enoyl-CoA hydratase
E2544_RS10390	COG0183	Belongs to the thiolase family
E2544_RS10415	COG1960	acyl-CoA dehydrogenase activity
E2544_RS10430	COG1802	Transcriptional regulator
E2544_RS10440	COG1024	Enoyl-CoA hydratase
E2544_RS10445	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS10455	COG0667	Aldo Keto reductase
E2544_RS10465	COG4120	Belongs to the binding-protein-dependent transport system permease family
E2544_RS10470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2544_RS10475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_RS10480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_RS10485	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E2544_RS10505	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E2544_RS10510	COG0725	ABC transporter, periplasmic molybdate-binding protein
E2544_RS10515	COG4149	molybdate abc transporter
E2544_RS10520	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E2544_RS10545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_RS10550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2544_RS10560	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E2544_RS10565	COG0736	holo-[acyl-carrier-protein] synthase activity
E2544_RS10580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E2544_RS10590	COG1858	cytochrome C peroxidase
E2544_RS10595	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E2544_RS10595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E2544_RS10600	COG2224	Isocitrate lyase
E2544_RS10615	COG2301	Belongs to the HpcH HpaI aldolase family
E2544_RS10620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS10635	COG4106	trans-aconitate 2-methyltransferase activity
E2544_RS10635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E2544_RS10645	COG0156	8-amino-7-oxononanoate synthase activity
E2544_RS10665	COG3278	Belongs to the heme-copper respiratory oxidase family
E2544_RS10685	COG0348	domain, Protein
E2544_RS10700	COG2824	Alkylphosphonate utilization operon protein PhnA
E2544_RS10710	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS10720	COG4948	Mandelate Racemase Muconate Lactonizing
E2544_RS10730	COG1131	(ABC) transporter
E2544_RS10735	COG0842	Transport permease protein
E2544_RS10750	COG0789	Transcriptional regulator
E2544_RS10775	COG1272	protein, Hemolysin III
E2544_RS10800	COG2169	Transcriptional regulator
E2544_RS10840	COG0251	oxidation-reduction process
E2544_RS10880	COG1566	PFAM secretion protein HlyD family protein
E2544_RS10905	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E2544_RS10920	COG1228	amidohydrolase
E2544_RS10935	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_RS10950	COG2814	Major facilitator Superfamily
E2544_RS10965	COG1464	Belongs to the NlpA lipoprotein family
E2544_RS10970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E2544_RS10975	COG2011	ABC-type metal ion transport system permease component
E2544_RS10990	COG2326	polyphosphate kinase activity
E2544_RS11000	COG0023	Translation Initiation Factor
E2544_RS11010	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS11030	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
E2544_RS11045	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS11050	COG1473	amidohydrolase
E2544_RS11055	COG0477	Major facilitator Superfamily
E2544_RS11065	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS11080	COG0583	DNA-binding transcription factor activity
E2544_RS11095	COG2951	lytic endotransglycosylase activity
E2544_RS11115	COG0519	Catalyzes the synthesis of GMP from XMP
E2544_RS11125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS11180	COG1522	sequence-specific DNA binding
E2544_RS11225	COG0625	glutathione transferase activity
E2544_RS11230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2544_RS11235	COG1595	DNA-templated transcription, initiation
E2544_RS11250	COG3530	Putative quorum-sensing-regulated virulence factor
E2544_RS11280	COG0443	Heat shock 70 kDa protein
E2544_RS11285	COG0494	nUDIX hydrolase
E2544_RS11315	COG0477	Major facilitator Superfamily
E2544_RS11325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2544_RS11335	COG0542	response to heat
E2544_RS11345	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2544_RS11355	COG3485	protocatechuate 3,4-dioxygenase
E2544_RS11360	COG1012	belongs to the aldehyde dehydrogenase family
E2544_RS11380	COG3119	arylsulfatase activity
E2544_RS11400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_RS11405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_RS11410	COG1802	Transcriptional regulator
E2544_RS11420	COG5441	Belongs to the UPF0261 family
E2544_RS11425	COG5564	TIM-barrel signal transduction protein
E2544_RS11440	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E2544_RS11455	COG1477	protein flavinylation
E2544_RS11480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E2544_RS11490	COG1562	ergosterol biosynthetic process
E2544_RS11500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E2544_RS11505	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS11515	COG1234	tRNA 3'-trailer cleavage
E2544_RS11535	COG3971	2-oxopent-4-enoate hydratase activity
E2544_RS11550	COG1012	belongs to the aldehyde dehydrogenase family
E2544_RS11555	COG3384	dioxygenase
E2544_RS11585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2544_RS11595	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS11605	COG2186	Transcriptional regulator
E2544_RS11635	COG0583	DNA-binding transcription factor activity
E2544_RS11640	COG0268	Binds directly to 16S ribosomal RNA
E2544_RS11650	COG0728	peptidoglycan biosynthetic process
E2544_RS11660	COG0563	adenylate kinase activity
E2544_RS11665	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E2544_RS11670	COG2835	tetraacyldisaccharide 4'-kinase activity
E2544_RS11675	COG1663	tetraacyldisaccharide 4'-kinase activity
E2544_RS11685	COG0811	peptide transport
E2544_RS11695	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E2544_RS11710	COG0183	Belongs to the thiolase family
E2544_RS11720	COG1278	Cold shock
E2544_RS11725	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E2544_RS11730	COG2373	Large extracellular alpha-helical protein
E2544_RS11735	COG4953	penicillin-binding protein 1C
E2544_RS11740	COG0542	response to heat
E2544_RS11745	COG2995	paraquat-inducible protein a
E2544_RS11750	COG3008	intermembrane lipid transfer
E2544_RS11760	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E2544_RS11760	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E2544_RS11760	COG0506	proline dehydrogenase activity
E2544_RS11790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS11795	COG1024	Enoyl-CoA hydratase
E2544_RS11805	COG1802	Transcriptional regulator
E2544_RS11810	COG2271	Major facilitator Superfamily
E2544_RS11830	COG1914	H( )-stimulated, divalent metal cation uptake system
E2544_RS11835	COG1764	response to oxidative stress
E2544_RS11845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS11850	COG0765	amino acid transport
E2544_RS11855	COG0765	amino acid transport
E2544_RS11860	COG1126	abc transporter atp-binding protein
E2544_RS11865	COG1902	pentaerythritol trinitrate reductase activity
E2544_RS11880	COG0583	DNA-binding transcription factor activity
E2544_RS11920	COG0154	amidase activity
E2544_RS11965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E2544_RS11970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E2544_RS11975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E2544_RS11980	COG0196	riboflavin kinase activity
E2544_RS11985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E2544_RS11990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2544_RS11990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2544_RS12005	COG0210	DNA helicase
E2544_RS12035	COG0488	(ABC) transporter
E2544_RS12040	COG2890	protein-(glutamine-N5) methyltransferase activity
E2544_RS12050	COG2171	N-acyltransferase activity
E2544_RS12090	COG3038	cytochrome b561
E2544_RS12095	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E2544_RS12110	COG3008	intermembrane lipid transfer
E2544_RS12125	COG1309	transcriptional regulator
E2544_RS12140	COG0583	DNA-binding transcription factor activity
E2544_RS12150	COG0251	oxidation-reduction process
E2544_RS12175	COG1278	Cold shock
E2544_RS12185	COG1278	Cold shock
E2544_RS12195	COG0501	Belongs to the peptidase M48B family
E2544_RS12200	COG0544	peptidyl-prolyl cis-trans isomerase activity
E2544_RS12205	COG0740	serine-type endopeptidase activity
E2544_RS12210	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E2544_RS12215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E2544_RS12220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E2544_RS12225	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS12230	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS12250	COG0556	nucleotide-excision repair
E2544_RS12255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2544_RS12265	COG1104	cysteine desulfurase activity
E2544_RS12270	COG0822	iron-sulfur transferase activity
E2544_RS12280	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E2544_RS12285	COG0443	Heat shock 70 kDa protein
E2544_RS12290	COG0633	Ferredoxin
E2544_RS12295	COG2975	iron-sulfur cluster assembly
E2544_RS12300	COG1803	Methylglyoxal synthase
E2544_RS12305	COG0583	DNA-binding transcription factor activity
E2544_RS12315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS12325	COG1024	Enoyl-CoA hydratase
E2544_RS12355	COG1022	Amp-dependent synthetase and ligase
E2544_RS12360	COG0183	Belongs to the thiolase family
E2544_RS12365	COG1309	transcriptional regulator
E2544_RS12375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E2544_RS12380	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS12390	COG2271	Major facilitator Superfamily
E2544_RS12395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E2544_RS12410	COG1136	(ABC) transporter
E2544_RS12425	COG0745	RESPONSE REGULATOR receiver
E2544_RS12430	COG4771	TonB-dependent receptor
E2544_RS12435	COG4607	ABC-type enterochelin transport system periplasmic component
E2544_RS12440	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2544_RS12445	COG4605	iron ion homeostasis
E2544_RS12450	COG4604	ABC transporter, ATP-binding protein
E2544_RS12455	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E2544_RS12465	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2544_RS12490	COG2146	nitrite reductase [NAD(P)H] activity
E2544_RS12515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS12520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS12555	COG1850	ribulose-bisphosphate carboxylase activity
E2544_RS12565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_RS12570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_RS12585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS12590	COG0765	amino acid transport
E2544_RS12595	COG0765	amino acid transport
E2544_RS12600	COG1126	abc transporter atp-binding protein
E2544_RS12605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E2544_RS12620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2544_RS12620	COG2146	nitrite reductase [NAD(P)H] activity
E2544_RS12625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2544_RS12625	COG2146	nitrite reductase [NAD(P)H] activity
E2544_RS12630	COG0583	DNA-binding transcription factor activity
E2544_RS12640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2544_RS12650	COG0613	PHP domain protein
E2544_RS12660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_RS12665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_RS12665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E2544_RS12675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E2544_RS12675	COG0047	phosphoribosylformylglycinamidine synthase activity
E2544_RS12680	COG4774	siderophore transport
E2544_RS12685	COG3712	iron ion homeostasis
E2544_RS12690	COG1595	DNA-templated transcription, initiation
E2544_RS12700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_RS12710	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS12800	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E2544_RS12830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2544_RS12830	COG0543	2 iron, 2 sulfur cluster binding
E2544_RS12840	COG0346	lactoylglutathione lyase activity
E2544_RS12855	COG1304	FMN binding
E2544_RS12885	COG4977	sequence-specific DNA binding
E2544_RS12890	COG1335	isochorismatase
E2544_RS12900	COG0129	dihydroxy-acid dehydratase activity
E2544_RS12910	COG2271	Major facilitator Superfamily
E2544_RS12915	COG0583	DNA-binding transcription factor activity
E2544_RS12920	COG4692	amylo-alpha-1,6-glucosidase activity
E2544_RS12965	COG3712	iron ion homeostasis
E2544_RS13055	COG0747	negative chemotaxis
E2544_RS13060	COG4608	Belongs to the ABC transporter superfamily
E2544_RS13065	COG0444	Belongs to the ABC transporter superfamily
E2544_RS13070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS13075	COG0601	transmembrane transport
E2544_RS13080	COG2072	flavoprotein involved in K transport
E2544_RS13090	COG4774	siderophore transport
E2544_RS13140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E2544_RS13140	COG2755	lipolytic protein G-D-S-L family
E2544_RS13150	COG0519	Catalyzes the synthesis of GMP from XMP
E2544_RS13150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2544_RS13160	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS13170	COG0702	epimerase
E2544_RS13195	COG0028	Belongs to the TPP enzyme family
E2544_RS13215	COG0583	DNA-binding transcription factor activity
E2544_RS13240	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E2544_RS13245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_RS13260	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E2544_RS13270	COG4221	oxidoreductase activity
E2544_RS13275	COG2814	Major facilitator Superfamily
E2544_RS13365	COG0583	DNA-binding transcription factor activity
E2544_RS13370	COG2814	Major facilitator Superfamily
E2544_RS13390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2544_RS13395	COG1902	pentaerythritol trinitrate reductase activity
E2544_RS13400	COG0667	Aldo Keto reductase
E2544_RS13460	COG2201	protein-glutamate methylesterase activity
E2544_RS13465	COG5001	Diguanylate cyclase
E2544_RS13465	COG2203	Gaf domain
E2544_RS13465	COG3706	GGDEF domain
E2544_RS13465	COG4251	negative regulation of phosphorylation
E2544_RS13470	COG1522	sequence-specific DNA binding
E2544_RS13495	COG0583	DNA-binding transcription factor activity
E2544_RS13515	COG3842	ATPase activity
E2544_RS13525	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS13530	COG1960	acyl-CoA dehydrogenase activity
E2544_RS13535	COG1960	acyl-CoA dehydrogenase activity
E2544_RS13540	COG0183	Belongs to the thiolase family
E2544_RS13545	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_RS13545	COG1024	Enoyl-CoA hydratase
E2544_RS13550	COG0583	DNA-binding transcription factor activity
E2544_RS13560	COG2733	membrane
E2544_RS13570	COG0625	glutathione transferase activity
E2544_RS13595	COG2885	chlorophyll binding
E2544_RS13610	COG0583	DNA-binding transcription factor activity
E2544_RS13630	COG2986	histidine ammonia-lyase
E2544_RS13640	COG0642	Histidine kinase
E2544_RS13660	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2544_RS13670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_RS13680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2544_RS13685	COG1846	Transcriptional regulator
E2544_RS13695	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS13715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2544_RS13720	COG0697	spore germination
E2544_RS13730	COG4941	Belongs to the sigma-70 factor family
E2544_RS13740	COG3795	YCII-related domain
E2544_RS13750	COG3795	YCII-related domain
E2544_RS13770	COG1360	Flagellar Motor Protein
E2544_RS13790	COG2207	Transcriptional regulator
E2544_RS13800	COG1683	Conserved Protein
E2544_RS13825	COG1309	transcriptional regulator
E2544_RS13835	COG4608	Belongs to the ABC transporter superfamily
E2544_RS13840	COG0444	Belongs to the ABC transporter superfamily
E2544_RS13845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS13850	COG0601	transmembrane transport
E2544_RS13860	COG1802	Transcriptional regulator
E2544_RS13865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E2544_RS13875	COG0667	Aldo Keto reductase
E2544_RS13890	COG1414	Transcriptional regulator
E2544_RS13895	COG1802	Transcriptional regulator
E2544_RS13905	COG1473	amidohydrolase
E2544_RS13915	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E2544_RS13970	COG2267	carboxylic ester hydrolase activity
E2544_RS14005	COG2271	Major facilitator Superfamily
E2544_RS14010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_RS14025	COG0587	DNA-directed DNA polymerase activity
E2544_RS14040	COG0833	amino acid
E2544_RS14045	COG0400	carboxylic ester hydrolase activity
E2544_RS14055	COG1566	PFAM secretion protein HlyD family protein
E2544_RS14075	COG0720	synthase
E2544_RS14080	COG0602	queuosine metabolic process
E2544_RS14095	COG0583	DNA-binding transcription factor activity
E2544_RS14100	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS14105	COG0154	amidase activity
E2544_RS14115	COG1902	pentaerythritol trinitrate reductase activity
E2544_RS14160	COG0842	Transport permease protein
E2544_RS14165	COG1131	(ABC) transporter
E2544_RS14175	COG1309	transcriptional regulator
E2544_RS14180	COG2130	NADP-dependent
E2544_RS14205	COG3842	ATPase activity
E2544_RS14210	COG3842	ATPase activity
E2544_RS14220	COG0395	ABC-type sugar transport system, permease component
E2544_RS14235	COG0583	DNA-binding transcription factor activity
E2544_RS14240	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS14245	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E2544_RS14255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2544_RS14265	COG2203	Gaf domain
E2544_RS14265	COG2199	diguanylate cyclase activity
E2544_RS14270	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS14275	COG3387	PFAM Glycoside hydrolase 15-related
E2544_RS14280	COG1960	acyl-CoA dehydrogenase activity
E2544_RS14310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_RS14315	COG0420	3'-5' exonuclease activity
E2544_RS14335	COG1960	acyl-CoA dehydrogenase activity
E2544_RS14340	COG1309	transcriptional regulator
E2544_RS14350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS14365	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS14370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E2544_RS14370	COG2111	Na H antiporter
E2544_RS14375	COG1006	Multisubunit Na H antiporter MnhC subunit
E2544_RS14380	COG0651	ATP synthesis coupled electron transport
E2544_RS14385	COG1863	multisubunit Na H antiporter MnhE subunit
E2544_RS14390	COG2212	antiporter activity
E2544_RS14415	COG1619	proteins homologs of microcin C7 resistance protein MccF
E2544_RS14435	COG0488	(ABC) transporter
E2544_RS14470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2544_RS14475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2544_RS14480	COG2252	PERMEase
E2544_RS14485	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E2544_RS14490	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E2544_RS14500	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2544_RS14525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E2544_RS14530	COG0789	Transcriptional regulator
E2544_RS14540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E2544_RS14540	COG0678	peroxiredoxin activity
E2544_RS14550	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E2544_RS14555	COG0584	glycerophosphoryl diester phosphodiesterase
E2544_RS14565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2544_RS14575	COG4181	ATPase activity
E2544_RS14585	COG1178	ABC-type Fe3 transport system permease component
E2544_RS14590	COG3842	ATPase activity
E2544_RS14595	COG0583	DNA-binding transcription factor activity
E2544_RS14600	COG0560	Phosphoserine phosphatase
E2544_RS14605	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E2544_RS14615	COG0583	DNA-binding transcription factor activity
E2544_RS14645	COG0583	DNA-binding transcription factor activity
E2544_RS14650	COG4336	lyase activity
E2544_RS14680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_RS14720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS14725	COG0765	amino acid transport
E2544_RS14730	COG1126	abc transporter atp-binding protein
E2544_RS14735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2544_RS14740	COG1758	RNA polymerase activity
E2544_RS14745	COG0194	GDP metabolic process
E2544_RS14750	COG3258	Cytochrome c
E2544_RS14755	COG2863	cytochrome
E2544_RS14760	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS14765	COG0791	NLP P60 protein
E2544_RS14770	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E2544_RS14775	COG0833	amino acid
E2544_RS14780	COG1561	YicC-like family, N-terminal region
E2544_RS14785	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E2544_RS14795	COG1960	acyl-CoA dehydrogenase activity
E2544_RS14810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E2544_RS14815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2544_RS14820	COG0174	glutamine synthetase
E2544_RS14830	COG2204	response regulator
E2544_RS14835	COG0583	DNA-binding transcription factor activity
E2544_RS14840	COG1741	Belongs to the pirin family
E2544_RS14845	COG1741	Belongs to the pirin family
E2544_RS14850	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS14855	COG3842	ATPase activity
E2544_RS14865	COG1840	ABC-type Fe3 transport system, periplasmic component
E2544_RS14880	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS14885	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS14890	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS14915	COG0583	DNA-binding transcription factor activity
E2544_RS14925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E2544_RS14930	COG0583	DNA-binding transcription factor activity
E2544_RS14935	COG0783	Belongs to the Dps family
E2544_RS14950	COG0745	RESPONSE REGULATOR receiver
E2544_RS14955	COG2205	protein histidine kinase activity
E2544_RS14970	COG3842	ATPase activity
E2544_RS14975	COG0395	ABC-type sugar transport system, permease component
E2544_RS14980	COG1175	transmembrane transport
E2544_RS14985	COG1653	transport
E2544_RS14995	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E2544_RS15005	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_RS15025	COG1794	racemase activity, acting on amino acids and derivatives
E2544_RS15030	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E2544_RS15040	COG0583	DNA-binding transcription factor activity
E2544_RS15045	COG0625	glutathione transferase activity
E2544_RS15050	COG2133	pyrroloquinoline quinone binding
E2544_RS15060	COG0697	spore germination
E2544_RS15065	COG2363	Small membrane protein
E2544_RS15095	COG0010	Belongs to the arginase family
E2544_RS15100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2544_RS15105	COG1464	Belongs to the NlpA lipoprotein family
E2544_RS15125	COG1408	metallophosphoesterase
E2544_RS15135	COG0688	phosphatidylethanolamine metabolic process
E2544_RS15150	COG0583	DNA-binding transcription factor activity
E2544_RS15165	COG0488	(ABC) transporter
E2544_RS15170	COG1686	Belongs to the peptidase S11 family
E2544_RS15195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_RS15200	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2544_RS15205	COG2200	EAL domain
E2544_RS15205	COG2199	diguanylate cyclase activity
E2544_RS15205	COG2203	Gaf domain
E2544_RS15210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2544_RS15225	COG2814	Major facilitator Superfamily
E2544_RS15240	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E2544_RS15245	COG2204	response regulator
E2544_RS15250	COG2204	response regulator
E2544_RS15280	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS15310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2544_RS15320	COG1289	transmembrane transporter activity
E2544_RS15325	COG3300	MHYT domain
E2544_RS15325	COG5001	Diguanylate cyclase
E2544_RS15335	COG1640	4-alpha-glucanotransferase
E2544_RS15340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E2544_RS15350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E2544_RS15360	COG0366	Alpha amylase catalytic
E2544_RS15365	COG0297	glycogen (starch) synthase activity
E2544_RS15370	COG0028	Belongs to the TPP enzyme family
E2544_RS15390	COG0392	lysyltransferase activity
E2544_RS15395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2544_RS15400	COG3568	Endonuclease Exonuclease Phosphatase
E2544_RS15405	COG4172	Belongs to the ABC transporter superfamily
E2544_RS15420	COG1253	flavin adenine dinucleotide binding
E2544_RS15430	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2544_RS15435	COG0714	Associated with various cellular activities
E2544_RS15470	COG3119	arylsulfatase activity
E2544_RS15505	COG2205	protein histidine kinase activity
E2544_RS15515	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E2544_RS15545	COG3706	GGDEF domain
E2544_RS15560	COG0628	permease
E2544_RS15570	COG1619	proteins homologs of microcin C7 resistance protein MccF
E2544_RS15585	COG0583	DNA-binding transcription factor activity
E2544_RS15635	COG1960	acyl-CoA dehydrogenase activity
E2544_RS15645	COG0531	amino acid
E2544_RS15660	COG0625	glutathione transferase activity
E2544_RS15675	COG1024	Enoyl-CoA hydratase
E2544_RS15680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS15685	COG0154	amidase activity
E2544_RS15695	COG2186	Transcriptional regulator
E2544_RS15700	COG2271	Major facilitator Superfamily
E2544_RS15725	COG0431	NADPH-dependent FMN reductase
E2544_RS15735	COG0798	PFAM Bile acid sodium symporter
E2544_RS15745	COG0346	lactoylglutathione lyase activity
E2544_RS15750	COG0640	Transcriptional regulator
E2544_RS15790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_RS15795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E2544_RS15875	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS15880	COG0477	Major facilitator Superfamily
E2544_RS15890	COG0583	DNA-binding transcription factor activity
E2544_RS15895	COG1335	isochorismatase
E2544_RS15915	COG2186	Transcriptional regulator
E2544_RS15920	COG0747	negative chemotaxis
E2544_RS15930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS15935	COG0444	Belongs to the ABC transporter superfamily
E2544_RS15940	COG4608	Belongs to the ABC transporter superfamily
E2544_RS15950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_RS15960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E2544_RS15960	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_RS15970	COG0028	Belongs to the TPP enzyme family
E2544_RS15980	COG1012	belongs to the aldehyde dehydrogenase family
E2544_RS15990	COG0235	Class ii aldolase
E2544_RS16000	COG0583	DNA-binding transcription factor activity
E2544_RS16010	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS16025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2544_RS16035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E2544_RS16040	COG0390	transport system, permease component
E2544_RS16060	COG1126	abc transporter atp-binding protein
E2544_RS16065	COG0765	amino acid transport
E2544_RS16070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS16090	COG0765	amino acid transport
E2544_RS16095	COG0010	Belongs to the arginase family
E2544_RS16100	COG1126	abc transporter atp-binding protein
E2544_RS16120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_RS16125	COG0596	Alpha beta hydrolase
E2544_RS16135	COG0346	lactoylglutathione lyase activity
E2544_RS16150	COG0028	Belongs to the TPP enzyme family
E2544_RS16160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2544_RS16190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2544_RS16195	COG0583	DNA-binding transcription factor activity
E2544_RS16220	COG4566	intracellular signal transduction
E2544_RS16240	COG0583	DNA-binding transcription factor activity
E2544_RS16255	COG1126	abc transporter atp-binding protein
E2544_RS16265	COG0765	amino acid transport
E2544_RS16285	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS16285	COG0604	alcohol dehydrogenase
E2544_RS16285	COG3321	synthase
E2544_RS16305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS16310	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS16325	COG2084	Dehydrogenase
E2544_RS16335	COG1073	alpha beta
E2544_RS16350	COG3485	protocatechuate 3,4-dioxygenase
E2544_RS16360	COG2885	chlorophyll binding
E2544_RS16365	COG2207	Transcriptional regulator
E2544_RS16385	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E2544_RS16395	COG4251	negative regulation of phosphorylation
E2544_RS16395	COG5001	Diguanylate cyclase
E2544_RS16395	COG3706	GGDEF domain
E2544_RS16395	COG2203	Gaf domain
E2544_RS16400	COG1960	acyl-CoA dehydrogenase activity
E2544_RS16415	COG0583	DNA-binding transcription factor activity
E2544_RS16450	COG1802	Transcriptional regulator
E2544_RS16455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_RS16460	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS16470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_RS16510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS16515	COG4597	amino acid ABC transporter
E2544_RS16525	COG3154	lipid carrier protein
E2544_RS16530	COG0826	peptidase U32
E2544_RS16535	COG0826	peptidase U32
E2544_RS16540	COG2197	response regulator
E2544_RS16545	COG3850	Histidine kinase
E2544_RS16550	COG1763	Mo-molybdopterin cofactor biosynthetic process
E2544_RS16555	COG0288	reversible hydration of carbon dioxide
E2544_RS16565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2544_RS16570	COG2181	nitrate reductase activity
E2544_RS16575	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E2544_RS16580	COG1140	nitrate reductase beta subunit
E2544_RS16585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E2544_RS16590	COG2223	nitrite transmembrane transporter activity
E2544_RS16630	COG0387	Pfam Sodium calcium exchanger
E2544_RS16640	COG0583	DNA-binding transcription factor activity
E2544_RS16720	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS16725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_RS16730	COG1414	Transcriptional regulator
E2544_RS16735	COG1309	transcriptional regulator
E2544_RS16750	COG1021	2,3-dihydroxybenzoate-AMP ligase
E2544_RS16765	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS16770	COG0583	DNA-binding transcription factor activity
E2544_RS16825	COG2070	2-Nitropropane dioxygenase
E2544_RS16835	COG3848	Pyruvate phosphate dikinase
E2544_RS16835	COG0574	Belongs to the PEP-utilizing enzyme family
E2544_RS16840	COG2205	protein histidine kinase activity
E2544_RS16845	COG0745	RESPONSE REGULATOR receiver
E2544_RS16850	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E2544_RS16855	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E2544_RS16865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2544_RS16870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2544_RS16880	COG0783	Belongs to the Dps family
E2544_RS16890	COG2879	small protein
E2544_RS16895	COG1966	Carbon starvation protein
E2544_RS16915	COG4521	taurine ABC transporter
E2544_RS16920	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E2544_RS16925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS16950	COG1228	amidohydrolase
E2544_RS16965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS16970	COG0601	transmembrane transport
E2544_RS16990	COG1414	Transcriptional regulator
E2544_RS16995	COG0513	Belongs to the DEAD box helicase family
E2544_RS17015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS17025	COG0840	transmembrane signaling receptor activity
E2544_RS17035	COG2814	Major facilitator Superfamily
E2544_RS17040	COG0386	Belongs to the glutathione peroxidase family
E2544_RS17045	COG1522	sequence-specific DNA binding
E2544_RS17055	COG0625	glutathione transferase activity
E2544_RS17070	COG0095	Lipoate-protein ligase
E2544_RS17080	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_RS17085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E2544_RS17090	COG0010	Belongs to the arginase family
E2544_RS17095	COG1126	abc transporter atp-binding protein
E2544_RS17100	COG0765	amino acid transport
E2544_RS17105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS17115	COG0154	amidase activity
E2544_RS17125	COG1137	ATPase activity
E2544_RS17145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS17150	COG1024	Enoyl-CoA hydratase
E2544_RS17160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2544_RS17175	COG0084	hydrolase, TatD family'
E2544_RS17180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E2544_RS17185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E2544_RS17190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E2544_RS17195	COG0354	folic acid binding
E2544_RS17215	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E2544_RS17220	COG1960	acyl-CoA dehydrogenase activity
E2544_RS17225	COG2914	Belongs to the UPF0125 (RnfH) family
E2544_RS17230	COG2867	negative regulation of translational initiation
E2544_RS17235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E2544_RS17245	COG0330	HflC and HflK could
E2544_RS17255	COG0519	Catalyzes the synthesis of GMP from XMP
E2544_RS17255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E2544_RS17260	COG2169	Transcriptional regulator
E2544_RS17260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2544_RS17280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2544_RS17285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E2544_RS17300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E2544_RS17305	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2544_RS17310	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E2544_RS17315	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2544_RS17320	COG0750	zinc metalloprotease
E2544_RS17325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E2544_RS17330	COG0575	Belongs to the CDS family
E2544_RS17335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E2544_RS17340	COG0233	cytoplasmic translational termination
E2544_RS17345	COG0528	UMP kinase activity
E2544_RS17350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E2544_RS17355	COG0052	Belongs to the universal ribosomal protein uS2 family
E2544_RS17360	COG0024	Methionine aminopeptidase
E2544_RS17365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E2544_RS17375	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E2544_RS17380	COG1451	nucleotide metabolic process
E2544_RS17390	COG1286	toxin biosynthetic process
E2544_RS17400	COG0285	dihydrofolate synthase activity
E2544_RS17410	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS17415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS17430	COG1334	flagellar protein FlaG
E2544_RS17455	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2544_RS17465	COG1677	Flagellar hook-basal body complex protein FliE
E2544_RS17475	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E2544_RS17485	COG1157	protein secretion by the type III secretion system
E2544_RS17500	COG1580	Controls the rotational direction of flagella during chemotaxis
E2544_RS17510	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E2544_RS17525	COG1987	bacterial-type flagellum assembly
E2544_RS17535	COG0840	transmembrane signaling receptor activity
E2544_RS17540	COG0840	transmembrane signaling receptor activity
E2544_RS17550	COG0840	transmembrane signaling receptor activity
E2544_RS17555	COG0840	transmembrane signaling receptor activity
E2544_RS17570	COG1705	Flagellar rod assembly protein muramidase FlgJ
E2544_RS17570	COG3951	Flagellar rod assembly protein muramidase FlgJ
E2544_RS17590	COG4787	bacterial-type flagellum-dependent cell motility
E2544_RS17605	COG1558	bacterial-type flagellum-dependent cell motility
E2544_RS17610	COG1815	bacterial-type flagellum-dependent cell motility
E2544_RS17620	COG2747	anti-sigma28 factor FlgM
E2544_RS17635	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2544_RS17640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2544_RS17650	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E2544_RS17655	COG0745	RESPONSE REGULATOR receiver
E2544_RS17660	COG2201	protein-glutamate methylesterase activity
E2544_RS17665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E2544_RS17670	COG0840	transmembrane signaling receptor activity
E2544_RS17675	COG0835	chemotaxis
E2544_RS17685	COG0745	RESPONSE REGULATOR receiver
E2544_RS17690	COG1360	Flagellar Motor Protein
E2544_RS17710	COG1191	sigma factor activity
E2544_RS17730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2544_RS17730	COG4797	methyltransferase
E2544_RS17750	COG4804	nuclease activity
E2544_RS17760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2544_RS17765	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_RS17780	COG4566	intracellular signal transduction
E2544_RS17785	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E2544_RS17790	COG0339	signal peptide processing
E2544_RS17800	COG1999	signal sequence binding
E2544_RS17825	COG0583	DNA-binding transcription factor activity
E2544_RS17830	COG1187	pseudouridine synthase activity
E2544_RS17875	COG3161	chorismate lyase activity
E2544_RS17905	COG0066	3-isopropylmalate dehydratase activity
E2544_RS17910	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E2544_RS17940	COG2188	Transcriptional regulator
E2544_RS17965	COG4681	YaeQ
E2544_RS17970	COG1280	lysine exporter protein (LysE YggA)
E2544_RS17975	COG4172	Belongs to the ABC transporter superfamily
E2544_RS17980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS17985	COG0601	transmembrane transport
E2544_RS17990	COG0747	negative chemotaxis
E2544_RS18000	COG0583	DNA-binding transcription factor activity
E2544_RS18100	COG0668	transmembrane transport
E2544_RS18105	COG0165	Argininosuccinate lyase
E2544_RS18110	COG1598	PFAM Uncharacterised protein family UPF0150
E2544_RS18115	COG0583	DNA-binding transcription factor activity
E2544_RS18120	COG2814	Major facilitator Superfamily
E2544_RS18130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_RS18160	COG0477	Major facilitator Superfamily
E2544_RS18190	COG0154	amidase activity
E2544_RS18195	COG0583	DNA-binding transcription factor activity
E2544_RS18210	COG0022	dehydrogenase e1 component
E2544_RS18235	COG1024	Enoyl-CoA hydratase
E2544_RS18240	COG2186	Transcriptional regulator
E2544_RS18245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS18250	COG0789	Transcriptional regulator
E2544_RS18275	COG0840	transmembrane signaling receptor activity
E2544_RS18285	COG2271	Major facilitator Superfamily
E2544_RS18300	COG0307	riboflavin synthase, alpha
E2544_RS18310	COG2186	Transcriptional regulator
E2544_RS18315	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS18350	COG0583	DNA-binding transcription factor activity
E2544_RS18365	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS18375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2544_RS18445	COG0183	Belongs to the thiolase family
E2544_RS18450	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS18480	COG1595	DNA-templated transcription, initiation
E2544_RS18485	COG3712	iron ion homeostasis
E2544_RS18495	COG0583	DNA-binding transcription factor activity
E2544_RS18515	COG0640	Transcriptional regulator
E2544_RS18535	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS18545	COG0411	ABC transporter
E2544_RS18580	COG1802	Transcriptional regulator
E2544_RS18585	COG5265	(ABC) transporter
E2544_RS18590	COG1280	lysine exporter protein (LysE YggA)
E2544_RS18635	COG2188	Transcriptional regulator
E2544_RS18650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2544_RS18670	COG0477	Major facilitator Superfamily
E2544_RS18675	COG0235	Class ii aldolase
E2544_RS18690	COG3685	Protein conserved in bacteria
E2544_RS18700	COG3546	catalase activity
E2544_RS18705	COG2188	Transcriptional regulator
E2544_RS18715	COG0583	DNA-binding transcription factor activity
E2544_RS18720	COG0477	Major facilitator Superfamily
E2544_RS18725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_RS18750	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS18755	COG0702	epimerase
E2544_RS18765	COG2610	gluconate transmembrane transporter activity
E2544_RS18770	COG0583	DNA-binding transcription factor activity
E2544_RS18775	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS18780	COG1024	Enoyl-CoA hydratase
E2544_RS18785	COG5001	Diguanylate cyclase
E2544_RS18790	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS18795	COG0129	dihydroxy-acid dehydratase activity
E2544_RS18810	COG2226	methyltransferase
E2544_RS18830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS18835	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E2544_RS18860	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2544_RS18880	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E2544_RS18885	COG1335	isochorismatase
E2544_RS18890	COG2309	aminopeptidase activity
E2544_RS18895	COG0596	Alpha beta hydrolase
E2544_RS18920	COG0583	DNA-binding transcription factor activity
E2544_RS18925	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_RS18930	COG3246	L-lysine catabolic process to acetate
E2544_RS18950	COG3043	anaerobic respiration
E2544_RS18955	COG3005	denitrification pathway
E2544_RS18960	COG4133	protoheme IX ABC transporter activity
E2544_RS18980	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E2544_RS18990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2544_RS19080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2544_RS19090	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS19100	COG2084	Dehydrogenase
E2544_RS19105	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS19115	COG2186	Transcriptional regulator
E2544_RS19120	COG0154	amidase activity
E2544_RS19145	COG1129	ABC transporter
E2544_RS19150	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E2544_RS19160	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E2544_RS19165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2544_RS19175	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS19180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E2544_RS19195	COG0697	spore germination
E2544_RS19200	COG0697	spore germination
E2544_RS19230	COG1280	lysine exporter protein (LysE YggA)
E2544_RS19250	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E2544_RS19275	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS19280	COG1960	acyl-CoA dehydrogenase activity
E2544_RS19285	COG2814	Major facilitator Superfamily
E2544_RS19300	COG0625	glutathione transferase activity
E2544_RS19305	COG0583	DNA-binding transcription factor activity
E2544_RS19310	COG0583	DNA-binding transcription factor activity
E2544_RS19325	COG0506	proline dehydrogenase activity
E2544_RS19330	COG0697	spore germination
E2544_RS19335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_RS19350	COG1610	YqeY-like protein
E2544_RS19395	COG0457	Tetratricopeptide repeat
E2544_RS19400	COG0726	polysaccharide deacetylase
E2544_RS19400	COG1649	PFAM Uncharacterised BCR, COG1649
E2544_RS19405	COG1215	transferase activity, transferring glycosyl groups
E2544_RS19415	COG2223	nitrite transmembrane transporter activity
E2544_RS19420	COG4977	sequence-specific DNA binding
E2544_RS19420	COG1917	Cupin 2, conserved barrel domain protein
E2544_RS19430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E2544_RS19445	COG0656	L-ascorbic acid biosynthetic process
E2544_RS19450	COG5265	(ABC) transporter
E2544_RS19465	COG0583	DNA-binding transcription factor activity
E2544_RS19480	COG1116	anion transmembrane transporter activity
E2544_RS19505	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS19545	COG1522	sequence-specific DNA binding
E2544_RS19570	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS19580	COG0456	acetyltransferase
E2544_RS19585	COG0384	phenazine biosynthesis protein PhzF
E2544_RS19600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2544_RS19605	COG0583	DNA-binding transcription factor activity
E2544_RS19610	COG0129	dihydroxy-acid dehydratase activity
E2544_RS19615	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS19620	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_RS19645	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E2544_RS19650	COG0789	Transcriptional regulator
E2544_RS19680	COG0776	regulation of translation
E2544_RS19685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2544_RS19685	COG0072	phenylalanine-tRNA ligase activity
E2544_RS19690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E2544_RS19695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E2544_RS19700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E2544_RS19705	COG0606	chelatase, subunit chli
E2544_RS19710	COG2960	long-chain fatty acid transporting porin activity
E2544_RS19720	COG0347	Belongs to the P(II) protein family
E2544_RS19725	COG0004	ammonium transporteR
E2544_RS19730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E2544_RS19735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2544_RS19750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E2544_RS19755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E2544_RS19765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2544_RS19790	COG0601	transmembrane transport
E2544_RS19795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS19820	COG1609	Transcriptional regulator
E2544_RS19825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E2544_RS19830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_RS19835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_RS19840	COG0129	dihydroxy-acid dehydratase activity
E2544_RS19850	COG0840	transmembrane signaling receptor activity
E2544_RS19860	COG2199	diguanylate cyclase activity
E2544_RS19860	COG2203	Gaf domain
E2544_RS19870	COG0135	phosphoribosylanthranilate isomerase activity
E2544_RS19875	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2544_RS19890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E2544_RS19910	COG1538	Outer membrane efflux protein
E2544_RS19920	COG2274	protein secretion by the type I secretion system
E2544_RS19925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_RS19955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E2544_RS19980	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E2544_RS19990	COG1295	ribonuclease BN
E2544_RS20000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E2544_RS20035	COG4964	Belongs to the GSP D family
E2544_RS20080	COG0583	DNA-binding transcription factor activity
E2544_RS20095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E2544_RS20130	COG1783	phage Terminase large subunit
E2544_RS20165	COG0582	viral genome integration into host DNA
E2544_RS20175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E2544_RS20185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E2544_RS20190	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E2544_RS20195	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E2544_RS20200	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E2544_RS20205	COG0330	HflC and HflK could
E2544_RS20210	COG0330	HflC and HflK could
E2544_RS20215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E2544_RS20220	COG1923	regulation of RNA biosynthetic process
E2544_RS20225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2544_RS20230	COG1160	GTP binding
E2544_RS20235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2544_RS20240	COG2976	Protein conserved in bacteria
E2544_RS20260	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E2544_RS20265	COG0105	UTP biosynthetic process
E2544_RS20270	COG0525	valine-tRNA ligase activity
E2544_RS20275	COG0336	Belongs to the RNA methyltransferase TrmD family
E2544_RS20280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E2544_RS20285	COG0228	four-way junction DNA binding
E2544_RS20295	COG0425	Belongs to the sulfur carrier protein TusA family
E2544_RS20300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2544_RS20350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_RS20365	COG2076	Multidrug Resistance protein
E2544_RS20370	COG0633	Ferredoxin
E2544_RS20370	COG3217	Mosc domain protein beta barrel domain protein
E2544_RS20375	COG5285	phytanoyl-CoA dioxygenase
E2544_RS20380	COG0662	Cupin 2, conserved barrel domain protein
E2544_RS20405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2544_RS20410	COG2358	TRAP transporter, solute receptor (TAXI family
E2544_RS20420	COG2311	Membrane
E2544_RS20440	COG0187	DNA topoisomerase II activity
E2544_RS20450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E2544_RS20460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E2544_RS20465	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E2544_RS20485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2544_RS20495	COG3391	amine dehydrogenase activity
E2544_RS20525	COG1846	Transcriptional regulator
E2544_RS20535	COG1566	PFAM secretion protein HlyD family protein
E2544_RS20540	COG2814	Major facilitator Superfamily
E2544_RS20550	COG0473	3-isopropylmalate dehydrogenase activity
E2544_RS20555	COG0433	COG0433 Predicted ATPase
E2544_RS20560	COG0217	transcriptional regulatory protein
E2544_RS20565	COG0151	Belongs to the GarS family
E2544_RS20575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E2544_RS20580	COG0799	negative regulation of ribosome biogenesis
E2544_RS20585	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E2544_RS20595	COG1301	dicarboxylic acid transport
E2544_RS20600	COG4191	Histidine kinase
E2544_RS20605	COG2204	response regulator
E2544_RS20635	COG1530	ribonuclease E activity
E2544_RS20640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2544_RS20645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_RS20650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_RS20650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E2544_RS20670	COG5001	Diguanylate cyclase
E2544_RS20670	COG2203	Gaf domain
E2544_RS20670	COG3706	GGDEF domain
E2544_RS20670	COG4251	negative regulation of phosphorylation
E2544_RS20680	COG0475	glutathione-regulated potassium exporter activity
E2544_RS20680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E2544_RS20685	COG1132	(ABC) transporter
E2544_RS20710	COG0726	polysaccharide deacetylase
E2544_RS20725	COG0726	polysaccharide deacetylase
E2544_RS20730	COG0438	transferase activity, transferring glycosyl groups
E2544_RS20745	COG1643	Atp-dependent helicase
E2544_RS20750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E2544_RS20750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E2544_RS20755	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E2544_RS20765	COG0704	Plays a role in the regulation of phosphate uptake
E2544_RS20770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E2544_RS20775	COG1960	acyl-CoA dehydrogenase activity
E2544_RS20795	COG2094	Belongs to the DNA glycosylase MPG family
E2544_RS20805	COG1177	transmembrane transport
E2544_RS20810	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2544_RS20815	COG3842	ATPase activity
E2544_RS20825	COG3642	lipopolysaccharide core region biosynthetic process
E2544_RS20835	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E2544_RS20840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E2544_RS20850	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E2544_RS20850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E2544_RS20855	COG4608	Belongs to the ABC transporter superfamily
E2544_RS20860	COG0444	Belongs to the ABC transporter superfamily
E2544_RS20875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS20880	COG0601	transmembrane transport
E2544_RS20885	COG0747	negative chemotaxis
E2544_RS20905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2544_RS20910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2544_RS20930	COG3618	amidohydrolase
E2544_RS20935	COG0583	DNA-binding transcription factor activity
E2544_RS20940	COG0137	argininosuccinate synthase activity
E2544_RS20945	COG3158	transport of potassium into the cell
E2544_RS20950	COG0642	Histidine kinase
E2544_RS20980	COG0776	regulation of translation
E2544_RS20985	COG3128	pkhd-type hydroxylase
E2544_RS20990	COG0626	cystathionine gamma-synthase activity
E2544_RS20995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2544_RS21000	COG0557	exoribonuclease II activity
E2544_RS21035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E2544_RS21040	COG2391	methyltransferase activity
E2544_RS21045	COG0069	glutamate synthase activity
E2544_RS21050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2544_RS21095	COG0697	spore germination
E2544_RS21155	COG3909	cytochrome
E2544_RS21165	COG0625	glutathione transferase activity
E2544_RS21170	COG0730	response to heat
E2544_RS21175	COG0482	sulfurtransferase activity
E2544_RS21180	COG0583	DNA-binding transcription factor activity
E2544_RS21210	COG0247	lactate metabolic process
E2544_RS21215	COG0277	FAD linked oxidase domain protein
E2544_RS21220	COG0277	FAD linked oxidase domain protein
E2544_RS21225	COG0277	FAD linked oxidase domain protein
E2544_RS21230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2544_RS21235	COG0312	modulator of DNA gyrase
E2544_RS21250	COG0308	aminopeptidase N
E2544_RS21255	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E2544_RS21275	COG0436	Aminotransferase
E2544_RS21285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2544_RS21290	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E2544_RS21310	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_RS21325	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS21340	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS21350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E2544_RS21370	COG0181	hydroxymethylbilane synthase activity
E2544_RS21375	COG0861	Integral membrane protein TerC family
E2544_RS21380	COG0861	Integral membrane protein TerC family
E2544_RS21385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E2544_RS21390	COG0045	succinate-CoA ligase (ADP-forming) activity
E2544_RS21405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E2544_RS21415	COG2137	regulation of response to DNA damage stimulus
E2544_RS21420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E2544_RS21455	COG0540	Belongs to the ATCase OTCase family
E2544_RS21485	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
E2544_RS21505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_RS21540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E2544_RS21550	COG0305	Participates in initiation and elongation during chromosome replication
E2544_RS21560	COG0359	binds to the 23S rRNA
E2544_RS21565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E2544_RS21570	COG2965	DNA replication, synthesis of RNA primer
E2544_RS21575	COG0360	Binds together with S18 to 16S ribosomal RNA
E2544_RS21580	COG3739	integral membrane protein
E2544_RS21585	COG1469	GTP cyclohydrolase I activity
E2544_RS21595	COG0142	geranyltranstransferase activity
E2544_RS21600	COG1722	exodeoxyribonuclease VII activity
E2544_RS21630	COG1840	ABC-type Fe3 transport system, periplasmic component
E2544_RS21635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2544_RS21645	COG3842	ATPase activity
E2544_RS21665	COG0583	DNA-binding transcription factor activity
E2544_RS21680	COG0501	Belongs to the peptidase M48B family
E2544_RS21685	COG1760	l-serine dehydratase
E2544_RS21690	COG1283	sodium-dependent phosphate transmembrane transporter activity
E2544_RS21695	COG0412	Dienelactone hydrolase
E2544_RS21700	COG0428	transporter
E2544_RS21715	COG1473	amidohydrolase
E2544_RS21730	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS21735	COG2271	Major facilitator Superfamily
E2544_RS21750	COG0583	DNA-binding transcription factor activity
E2544_RS21755	COG0583	DNA-binding transcription factor activity
E2544_RS21765	COG1217	gtp-binding protein TYPA
E2544_RS21770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E2544_RS21775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E2544_RS21780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E2544_RS21785	COG2251	uridine kinase activity
E2544_RS21785	COG0195	Participates in both transcription termination and antitermination
E2544_RS21790	COG0779	Required for maturation of 30S ribosomal subunits
E2544_RS21795	COG1187	pseudouridine synthase activity
E2544_RS21800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E2544_RS21810	COG0583	DNA-binding transcription factor activity
E2544_RS21815	COG0523	cobalamin synthesis protein
E2544_RS21835	COG0642	Histidine kinase
E2544_RS21840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2544_RS21845	COG0625	glutathione transferase activity
E2544_RS21850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E2544_RS21855	COG1047	Peptidyl-prolyl cis-trans
E2544_RS21860	COG2003	Belongs to the UPF0758 family
E2544_RS21865	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E2544_RS21870	COG3483	tryptophan 2,3-dioxygenase activity
E2544_RS21895	COG2050	protein possibly involved in aromatic compounds catabolism
E2544_RS21900	COG1024	Enoyl-CoA hydratase
E2544_RS21905	COG1012	belongs to the aldehyde dehydrogenase family
E2544_RS21910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2544_RS21915	COG2151	metal-sulfur cluster biosynthetic enzyme
E2544_RS21920	COG3396	Phenylacetate-CoA oxygenase
E2544_RS21925	COG3460	Phenylacetate-CoA oxygenase
E2544_RS21930	COG3396	Phenylacetate-CoA oxygenase
E2544_RS21935	COG3327	negative regulation of DNA-templated transcription, initiation
E2544_RS21940	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E2544_RS21960	COG2204	response regulator
E2544_RS21965	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E2544_RS21970	COG0501	Belongs to the peptidase M48B family
E2544_RS21975	COG1162	GTPase activity
E2544_RS21985	COG0335	large ribosomal subunit rRNA binding
E2544_RS22015	COG0175	sulfate reduction
E2544_RS22020	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E2544_RS22025	COG4208	sulfate ABC transporter
E2544_RS22030	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E2544_RS22035	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E2544_RS22040	COG0450	alkyl hydroperoxide reductase
E2544_RS22045	COG1960	acyl-CoA dehydrogenase activity
E2544_RS22055	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_RS22055	COG1024	Enoyl-CoA hydratase
E2544_RS22060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS22070	COG2985	domain, Protein
E2544_RS22095	COG0123	including yeast histone deacetylase and acetoin utilization protein
E2544_RS22100	COG2951	lytic endotransglycosylase activity
E2544_RS22130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2544_RS22135	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E2544_RS22140	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E2544_RS22160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E2544_RS22165	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E2544_RS22170	COG0287	Prephenate dehydrogenase
E2544_RS22175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2544_RS22180	COG1605	Chorismate mutase
E2544_RS22180	COG0077	Prephenate dehydratase
E2544_RS22185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E2544_RS22200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2544_RS22230	COG1960	acyl-CoA dehydrogenase activity
E2544_RS22240	COG2030	dehydratase
E2544_RS22245	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS22255	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS22265	COG0045	succinate-CoA ligase (ADP-forming) activity
E2544_RS22270	COG1960	acyl-CoA dehydrogenase activity
E2544_RS22280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS22285	COG1024	Enoyl-CoA hydratase
E2544_RS22290	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS22295	COG0583	DNA-binding transcription factor activity
E2544_RS22310	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS22315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E2544_RS22325	COG1215	transferase activity, transferring glycosyl groups
E2544_RS22345	COG2951	lytic endotransglycosylase activity
E2544_RS22350	COG2833	Protein of unknown function (DUF455)
E2544_RS22365	COG1132	(ABC) transporter
E2544_RS22370	COG0189	ligase activity
E2544_RS22370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2544_RS22375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2544_RS22375	COG0189	ligase activity
E2544_RS22380	COG3237	CsbD-like
E2544_RS22390	COG2823	Periplasmic or secreted lipoprotein
E2544_RS22405	COG0672	)-iron permease
E2544_RS22425	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E2544_RS22430	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS22435	COG3243	poly(R)-hydroxyalkanoic acid synthase
E2544_RS22440	COG1496	oxidoreductase activity
E2544_RS22445	COG0564	pseudouridine synthase activity
E2544_RS22465	COG1199	ATP-dependent helicase activity
E2544_RS22470	COG2183	response to ionizing radiation
E2544_RS22505	COG4774	siderophore transport
E2544_RS22510	COG3712	iron ion homeostasis
E2544_RS22515	COG1595	DNA-templated transcription, initiation
E2544_RS22520	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E2544_RS22525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2544_RS22530	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_RS22535	COG0567	Dehydrogenase, E1 component
E2544_RS22540	COG1522	sequence-specific DNA binding
E2544_RS22545	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E2544_RS22560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_RS22565	COG1297	OPT oligopeptide transporter protein
E2544_RS22575	COG0280	phosphate acetyltransferase
E2544_RS22575	COG0281	malic enzyme
E2544_RS22590	COG0372	Belongs to the citrate synthase family
E2544_RS22595	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E2544_RS22600	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E2544_RS22605	COG1053	succinate dehydrogenase
E2544_RS22610	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E2544_RS22615	COG2009	succinate dehydrogenase
E2544_RS22620	COG2188	Transcriptional regulator
E2544_RS22625	COG0039	L-malate dehydrogenase activity
E2544_RS22645	COG1981	membrane
E2544_RS22675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2544_RS22685	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E2544_RS22700	COG0148	phosphopyruvate hydratase activity
E2544_RS22715	COG0504	CTP synthase activity
E2544_RS22740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS22750	COG0747	negative chemotaxis
E2544_RS22755	COG4172	Belongs to the ABC transporter superfamily
E2544_RS22760	COG1446	asparaginase
E2544_RS22770	COG2153	protein acetylation
E2544_RS22795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2544_RS22825	COG0747	negative chemotaxis
E2544_RS22840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2544_RS22845	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E2544_RS22850	COG0697	spore germination
E2544_RS22855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2544_RS22865	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E2544_RS22870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2544_RS22875	COG0791	NLP P60 protein
E2544_RS22885	COG0583	DNA-binding transcription factor activity
E2544_RS22910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E2544_RS22940	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS22950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E2544_RS22960	COG1381	Involved in DNA repair and RecF pathway recombination
E2544_RS22965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E2544_RS22970	COG0571	ribonuclease III activity
E2544_RS22975	COG0681	Belongs to the peptidase S26 family
E2544_RS22985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2544_RS23010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2544_RS23015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2544_RS23025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E2544_RS23030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2544_RS23035	COG0416	fatty acid biosynthetic process
E2544_RS23040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E2544_RS23045	COG1399	metal-binding, possibly nucleic acid-binding protein
E2544_RS23050	COG0424	maF-like protein
E2544_RS23060	COG3023	N-Acetylmuramoyl-L-alanine amidase
E2544_RS23065	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E2544_RS23070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E2544_RS23085	COG1530	ribonuclease E activity
E2544_RS23100	COG2721	sulfolactate sulfo-lyase activity
E2544_RS23110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E2544_RS23115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E2544_RS23120	COG0159	tryptophan synthase activity
E2544_RS23130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_RS23140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2544_RS23145	COG3228	Belongs to the MtfA family
E2544_RS23150	COG0655	NAD(P)H dehydrogenase (quinone) activity
E2544_RS23155	COG0251	oxidation-reduction process
E2544_RS23160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E2544_RS23165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E2544_RS23180	COG2878	Part of a membrane complex involved in electron transport
E2544_RS23185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E2544_RS23220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E2544_RS23255	COG1268	BioY protein
E2544_RS23260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E2544_RS23265	COG1122	ATPase activity
E2544_RS23270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2544_RS23275	COG2917	probably involved in intracellular septation
E2544_RS23285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2544_RS23290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2544_RS23295	COG2175	clavaminate synthase activity
E2544_RS23310	COG1414	Transcriptional regulator
E2544_RS23315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E2544_RS23325	COG1196	nuclear chromosome segregation
E2544_RS23330	COG0477	Major facilitator Superfamily
E2544_RS23335	COG1573	uracil-dna glycosylase
E2544_RS23340	COG1214	PFAM Peptidase M22, glycoprotease
E2544_RS23355	COG0450	alkyl hydroperoxide reductase
E2544_RS23360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2544_RS23370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E2544_RS23375	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E2544_RS23380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E2544_RS23385	COG0560	Phosphoserine phosphatase
E2544_RS23390	COG4774	siderophore transport
E2544_RS23400	COG1007	ATP synthesis coupled electron transport
E2544_RS23415	COG0713	ATP synthesis coupled electron transport
E2544_RS23425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2544_RS23430	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E2544_RS23435	COG1034	ATP synthesis coupled electron transport
E2544_RS23445	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E2544_RS23455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2544_RS23460	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2544_RS23465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E2544_RS23470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_RS23495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E2544_RS23520	COG1309	transcriptional regulator
E2544_RS23525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_RS23530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2544_RS23550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2544_RS23560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E2544_RS23570	COG1309	transcriptional regulator
E2544_RS23580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2544_RS23600	COG0726	polysaccharide deacetylase
E2544_RS23625	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E2544_RS23635	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS23640	COG0747	negative chemotaxis
E2544_RS23670	COG2354	Protein conserved in bacteria
E2544_RS23675	COG3813	Protein conserved in bacteria
E2544_RS23680	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
E2544_RS23685	COG3604	Transcriptional regulator
E2544_RS23695	COG0604	alcohol dehydrogenase
E2544_RS23700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS23705	COG0583	DNA-binding transcription factor activity
E2544_RS23710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2544_RS23720	COG0477	Major facilitator Superfamily
E2544_RS23730	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_RS23740	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_RS23740	COG0022	dehydrogenase e1 component
E2544_RS23755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS23760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS23775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E2544_RS23785	COG1609	Transcriptional regulator
E2544_RS23790	COG2084	Dehydrogenase
E2544_RS23795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS23800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS23810	COG3119	arylsulfatase activity
E2544_RS23820	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS23825	COG2851	Citrate transporter
E2544_RS23835	COG0642	Histidine kinase
E2544_RS23865	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS23910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_RS23915	COG0697	spore germination
E2544_RS23935	COG3048	D-serine ammonia-lyase activity
E2544_RS23940	COG0583	DNA-binding transcription factor activity
E2544_RS23945	COG1971	Probably functions as a manganese efflux pump
E2544_RS23950	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS23990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2544_RS24010	COG0747	negative chemotaxis
E2544_RS24015	COG0601	transmembrane transport
E2544_RS24020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS24025	COG0444	Belongs to the ABC transporter superfamily
E2544_RS24030	COG4608	Belongs to the ABC transporter superfamily
E2544_RS24035	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E2544_RS24050	COG1960	acyl-CoA dehydrogenase activity
E2544_RS24065	COG1024	Enoyl-CoA hydratase
E2544_RS24090	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E2544_RS24100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E2544_RS24140	COG1126	abc transporter atp-binding protein
E2544_RS24150	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2544_RS24155	COG1177	transmembrane transport
E2544_RS24160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_RS24165	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E2544_RS24180	COG3842	ATPase activity
E2544_RS24185	COG2072	flavoprotein involved in K transport
E2544_RS24195	COG0071	Belongs to the small heat shock protein (HSP20) family
E2544_RS24220	COG5383	Protein conserved in bacteria
E2544_RS24225	COG0583	DNA-binding transcription factor activity
E2544_RS24240	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2544_RS24250	COG0647	UMP catabolic process
E2544_RS24255	COG1737	Transcriptional regulator
E2544_RS24260	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2544_RS24265	COG0149	triose-phosphate isomerase activity
E2544_RS24270	COG3321	synthase
E2544_RS24270	COG0604	alcohol dehydrogenase
E2544_RS24290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_RS24300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS24330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2544_RS24340	COG1185	polyribonucleotide nucleotidyltransferase activity
E2544_RS24345	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E2544_RS24355	COG1183	phosphatidylcholine synthase activity
E2544_RS24360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E2544_RS24365	COG0440	acetolactate synthase activity
E2544_RS24370	COG0028	Belongs to the TPP enzyme family
E2544_RS24375	COG1289	transmembrane transporter activity
E2544_RS24380	COG3022	response to hydroperoxide
E2544_RS24385	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS24400	COG0840	transmembrane signaling receptor activity
E2544_RS24405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2544_RS24410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2544_RS24415	COG0477	Major facilitator Superfamily
E2544_RS24425	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E2544_RS24470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E2544_RS24475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E2544_RS24480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2544_RS24495	COG0601	transmembrane transport
E2544_RS24515	COG1737	Transcriptional regulator
E2544_RS24520	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E2544_RS24530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E2544_RS24535	COG1674	ftsk spoiiie
E2544_RS24540	COG0492	ferredoxin-NADP+ reductase activity
E2544_RS24545	COG1193	negative regulation of DNA recombination
E2544_RS24555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2544_RS24570	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E2544_RS24575	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E2544_RS24580	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E2544_RS24585	COG2205	protein histidine kinase activity
E2544_RS24590	COG0745	RESPONSE REGULATOR receiver
E2544_RS24605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_RS24610	COG0840	transmembrane signaling receptor activity
E2544_RS24635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2544_RS24660	COG0612	Peptidase, M16
E2544_RS24670	COG0484	heat shock protein binding
E2544_RS24675	COG0443	Heat shock 70 kDa protein
E2544_RS24685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E2544_RS24695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E2544_RS24700	COG1420	regulation of RNA biosynthetic process
E2544_RS24710	COG0497	DNA recombination
E2544_RS24715	COG0735	belongs to the Fur family
E2544_RS24720	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2544_RS24755	COG0583	DNA-binding transcription factor activity
E2544_RS24795	COG1053	succinate dehydrogenase
E2544_RS24810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E2544_RS24820	COG3188	usher protein
E2544_RS24825	COG3121	Chaperone
E2544_RS24835	COG2197	response regulator
E2544_RS24845	COG2202	Pas domain
E2544_RS24845	COG2200	EAL domain
E2544_RS24845	COG2199	diguanylate cyclase activity
E2544_RS24850	COG2205	protein histidine kinase activity
E2544_RS24850	COG0784	Response regulator, receiver
E2544_RS24855	COG3969	phosphoadenosine phosphosulfate
E2544_RS24860	COG1475	DNA binding
E2544_RS24915	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E2544_RS24920	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E2544_RS24925	COG0167	dihydroorotate dehydrogenase activity
E2544_RS24940	COG1414	Transcriptional regulator
E2544_RS24945	COG1546	Belongs to the CinA family
E2544_RS24945	COG1058	Belongs to the CinA family
E2544_RS24960	COG0513	Belongs to the DEAD box helicase family
E2544_RS24990	COG0429	hydrolase of the alpha beta-hydrolase fold
E2544_RS24995	COG4783	chaperone-mediated protein folding
E2544_RS25010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_RS25015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E2544_RS25030	COG0006	proline dipeptidase activity
E2544_RS25040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2544_RS25060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E2544_RS25065	COG0632	four-way junction helicase activity
E2544_RS25070	COG1090	epimerase
E2544_RS25080	COG2255	four-way junction helicase activity
E2544_RS25100	COG0514	ATP-dependent DNA helicase (RecQ)
E2544_RS25110	COG1271	oxidase subunit
E2544_RS25115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2544_RS25120	COG0850	regulation of cytokinetic process
E2544_RS25125	COG2894	cell division
E2544_RS25130	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E2544_RS25145	COG0488	(ABC) transporter
E2544_RS25165	COG4608	Belongs to the ABC transporter superfamily
E2544_RS25170	COG0444	Belongs to the ABC transporter superfamily
E2544_RS25175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS25180	COG0601	transmembrane transport
E2544_RS25185	COG4166	transmembrane transport
E2544_RS25215	COG4638	Rieske (2fe-2S)
E2544_RS25240	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E2544_RS25245	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS25270	COG0463	Glycosyl transferase, family 2
E2544_RS25270	COG1216	Glycosyl transferase, family 2
E2544_RS25295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E2544_RS25330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E2544_RS25335	COG1538	Outer membrane efflux protein
E2544_RS25340	COG0577	efflux transmembrane transporter activity
E2544_RS25340	COG1136	(ABC) transporter
E2544_RS25345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_RS25360	COG0259	pyridoxamine-phosphate oxidase activity
E2544_RS25370	COG0579	oxidoreductase
E2544_RS25380	COG0659	secondary active sulfate transmembrane transporter activity
E2544_RS25385	COG0583	DNA-binding transcription factor activity
E2544_RS25390	COG1960	acyl-CoA dehydrogenase activity
E2544_RS25395	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS25400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS25405	COG0405	Gamma-glutamyltransferase
E2544_RS25415	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS25425	COG0114	fumarate hydratase activity
E2544_RS25430	COG0802	atpase or kinase
E2544_RS25435	COG0860	N-Acetylmuramoyl-L-alanine amidase
E2544_RS25440	COG0586	Pfam SNARE associated Golgi protein
E2544_RS25445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E2544_RS25450	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E2544_RS25455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E2544_RS25470	COG0617	tRNA 3'-terminal CCA addition
E2544_RS25480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2544_RS25490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS25495	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E2544_RS25500	COG0583	DNA-binding transcription factor activity
E2544_RS25505	COG1024	Enoyl-CoA hydratase
E2544_RS25515	COG1960	acyl-CoA dehydrogenase activity
E2544_RS25530	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS25550	COG0583	DNA-binding transcription factor activity
E2544_RS25555	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS25560	COG2030	dehydratase
E2544_RS25565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS25575	COG1024	Enoyl-CoA hydratase
E2544_RS25580	COG0752	glycyl-tRNA synthetase alpha subunit
E2544_RS25585	COG0751	glycine-tRNA ligase activity
E2544_RS25590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2544_RS25595	COG0204	Acyl-transferase
E2544_RS25615	COG0242	peptide deformylase activity
E2544_RS25625	COG0700	Nucleoside recognition
E2544_RS25630	COG0469	pyruvate kinase activity
E2544_RS25635	COG1929	Belongs to the glycerate kinase type-1 family
E2544_RS25640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E2544_RS25645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2544_RS25660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E2544_RS25685	COG2154	pterin-4-alpha-carbinolamine dehydratase
E2544_RS25705	COG0436	Aminotransferase
E2544_RS25715	COG1522	sequence-specific DNA binding
E2544_RS25730	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS25745	COG2982	Protein involved in outer membrane biogenesis
E2544_RS25750	COG1368	sulfuric ester hydrolase activity
E2544_RS25755	COG2818	Glycosylase
E2544_RS25775	COG0735	belongs to the Fur family
E2544_RS25800	COG2011	ABC-type metal ion transport system permease component
E2544_RS25805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E2544_RS25810	COG1501	Belongs to the glycosyl hydrolase 31 family
E2544_RS25815	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E2544_RS25815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2544_RS25825	COG0318	PFAM AMP-dependent synthetase and ligase
E2544_RS25830	COG1473	amidohydrolase
E2544_RS25840	COG2855	membrane
E2544_RS25850	COG2239	Acts as a magnesium transporter
E2544_RS25865	COG1522	sequence-specific DNA binding
E2544_RS25870	COG0300	oxidoreductase activity
E2544_RS25880	COG0028	Belongs to the TPP enzyme family
E2544_RS25885	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS25900	COG0653	protein targeting
E2544_RS25905	COG0739	heme binding
E2544_RS25915	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E2544_RS25920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E2544_RS25930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E2544_RS25935	COG1181	Belongs to the D-alanine--D-alanine ligase family
E2544_RS25940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2544_RS25945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E2544_RS25955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E2544_RS25960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2544_RS25965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2544_RS25975	COG3116	cell division
E2544_RS25980	COG0275	rRNA processing
E2544_RS25985	COG2001	Belongs to the MraZ family
E2544_RS25995	COG0488	(ABC) transporter
E2544_RS26000	COG0418	dihydroorotase activity
E2544_RS26005	COG1473	amidohydrolase
E2544_RS26065	COG1522	sequence-specific DNA binding
E2544_RS26075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2544_RS26080	COG4654	Cytochrome c, class I
E2544_RS26085	COG0129	dihydroxy-acid dehydratase activity
E2544_RS26130	COG2084	Dehydrogenase
E2544_RS26145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2544_RS26180	COG0824	Thioesterase
E2544_RS26185	COG0811	peptide transport
E2544_RS26190	COG0848	biopolymer transport protein
E2544_RS26200	COG0823	Involved in the tonB-independent uptake of proteins
E2544_RS26215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2544_RS26220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E2544_RS26235	COG1522	sequence-specific DNA binding
E2544_RS26245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2544_RS26260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_RS26265	COG0697	spore germination
E2544_RS26275	COG1346	cytolysis
E2544_RS26285	COG0583	DNA-binding transcription factor activity
E2544_RS26295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_RS26300	COG1129	ABC transporter
E2544_RS26335	COG0583	DNA-binding transcription factor activity
E2544_RS26355	COG0463	Glycosyl transferase, family 2
E2544_RS26365	COG0786	glutamate:sodium symporter activity
E2544_RS26380	COG1671	Belongs to the UPF0178 family
E2544_RS26405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2544_RS26410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2544_RS26415	COG0328	RNA-DNA hybrid ribonuclease activity
E2544_RS26420	COG2226	methyltransferase
E2544_RS26425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2544_RS26430	COG0741	lytic transglycosylase activity
E2544_RS26430	COG1388	LysM domain
E2544_RS26435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2544_RS26440	COG3608	succinylglutamate desuccinylase aspartoacylase
E2544_RS26465	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS26490	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS26510	COG2719	SpoVR family
E2544_RS26515	COG2718	Belongs to the UPF0229 family
E2544_RS26520	COG2766	serine protein kinase
E2544_RS26535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2544_RS26535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2544_RS26545	COG2207	Transcriptional regulator
E2544_RS26550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E2544_RS26555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E2544_RS26565	COG1881	PFAM PEBP family protein
E2544_RS26570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E2544_RS26580	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E2544_RS26585	COG0316	Belongs to the HesB IscA family
E2544_RS26595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2544_RS26600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E2544_RS26605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E2544_RS26620	COG4177	L-phenylalanine transmembrane transporter activity
E2544_RS26625	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2544_RS26635	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E2544_RS26640	COG0312	modulator of DNA gyrase
E2544_RS26660	COG1116	anion transmembrane transporter activity
E2544_RS26665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2544_RS26670	COG1335	isochorismatase
E2544_RS26675	COG0045	succinate-CoA ligase (ADP-forming) activity
E2544_RS26675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2544_RS26675	COG1042	CoA-binding domain protein
E2544_RS26680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2544_RS26695	COG0583	DNA-binding transcription factor activity
E2544_RS26705	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS26710	COG1522	sequence-specific DNA binding
E2544_RS26735	COG0762	integral membrane protein
E2544_RS26740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2544_RS26745	COG1696	Membrane protein involved in D-alanine export
E2544_RS26770	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E2544_RS26770	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2544_RS26780	COG2264	protein methyltransferase activity
E2544_RS26785	COG0439	Biotin carboxylase
E2544_RS26790	COG0511	ligase activity, forming carbon-carbon bonds
E2544_RS26795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E2544_RS26800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2544_RS26805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2544_RS26810	COG3150	esterase
E2544_RS26815	COG0557	exoribonuclease II activity
E2544_RS26835	COG1175	transmembrane transport
E2544_RS26850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E2544_RS26855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2544_RS26865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E2544_RS26870	COG1126	abc transporter atp-binding protein
E2544_RS26875	COG0765	amino acid transport
E2544_RS26885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS26890	COG0436	Aminotransferase
E2544_RS26895	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2544_RS26915	COG0540	Belongs to the ATCase OTCase family
E2544_RS26920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E2544_RS26925	COG1678	Uncharacterized ACR, COG1678
E2544_RS26935	COG0351	phosphomethylpyrimidine kinase
E2544_RS26935	COG0352	thiamine-phosphate diphosphorylase activity
E2544_RS26935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E2544_RS26940	COG0352	thiamine-phosphate diphosphorylase activity
E2544_RS26945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E2544_RS26950	COG0741	lytic transglycosylase activity
E2544_RS26960	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS26965	COG1335	isochorismatase
E2544_RS26970	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E2544_RS26975	COG4638	Rieske (2fe-2S)
E2544_RS27015	COG1024	Enoyl-CoA hydratase
E2544_RS27020	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS27030	COG2199	diguanylate cyclase activity
E2544_RS27030	COG2200	EAL domain
E2544_RS27030	COG2202	Pas domain
E2544_RS27090	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E2544_RS27130	COG0683	leucine binding
E2544_RS27135	COG0154	amidase activity
E2544_RS27140	COG0583	DNA-binding transcription factor activity
E2544_RS27145	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS27180	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E2544_RS27185	COG0237	dephospho-CoA kinase activity
E2544_RS27205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E2544_RS27210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E2544_RS27220	COG0477	Major facilitator Superfamily
E2544_RS27230	COG0129	dihydroxy-acid dehydratase activity
E2544_RS27240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_RS27245	COG0583	DNA-binding transcription factor activity
E2544_RS27260	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E2544_RS27265	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E2544_RS27270	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2544_RS27275	COG2031	fatty acid transporter
E2544_RS27280	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS27285	COG1414	Transcriptional regulator
E2544_RS27295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2544_RS27300	COG4829	muconolactone delta-isomerase
E2544_RS27310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2544_RS27325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E2544_RS27330	COG2890	protein-(glutamine-N5) methyltransferase activity
E2544_RS27335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E2544_RS27350	COG1196	nuclear chromosome segregation
E2544_RS27350	COG3264	Mechanosensitive ion channel
E2544_RS27360	COG1132	(ABC) transporter
E2544_RS27390	COG1522	sequence-specific DNA binding
E2544_RS27415	COG3622	Belongs to the hyi family
E2544_RS27420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2544_RS27425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS27450	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E2544_RS27455	COG1012	belongs to the aldehyde dehydrogenase family
E2544_RS27460	COG0583	DNA-binding transcription factor activity
E2544_RS27470	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2544_RS27485	COG0022	dehydrogenase e1 component
E2544_RS27490	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS27515	COG2186	Transcriptional regulator
E2544_RS27520	COG3395	kinase activity
E2544_RS27525	COG2084	Dehydrogenase
E2544_RS27530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2544_RS27535	COG3622	Belongs to the hyi family
E2544_RS27540	COG2271	Major facilitator Superfamily
E2544_RS27545	COG0235	Class ii aldolase
E2544_RS27560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E2544_RS27575	COG2084	Dehydrogenase
E2544_RS27580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2544_RS27585	COG0683	leucine binding
E2544_RS27615	COG2226	methyltransferase
E2544_RS27615	COG1073	alpha beta
E2544_RS27625	COG0523	cobalamin synthesis protein
E2544_RS27630	COG1335	isochorismatase
E2544_RS27640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E2544_RS27645	COG1802	Transcriptional regulator
E2544_RS27650	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E2544_RS27660	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS27670	COG4774	siderophore transport
E2544_RS27685	COG4585	Histidine kinase
E2544_RS27695	COG3119	arylsulfatase activity
E2544_RS27705	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS27715	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E2544_RS27725	COG0142	geranyltranstransferase activity
E2544_RS27740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E2544_RS27745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E2544_RS27750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E2544_RS27755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E2544_RS27770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2544_RS27785	COG2186	Transcriptional regulator
E2544_RS27795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E2544_RS27800	COG0793	Belongs to the peptidase S41A family
E2544_RS27805	COG4942	peptidase
E2544_RS27810	COG0588	phosphoglycerate mutase activity
E2544_RS27815	COG1054	Belongs to the UPF0176 family
E2544_RS27820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E2544_RS27825	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E2544_RS27830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E2544_RS27840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E2544_RS27845	COG1040	competence protein
E2544_RS27850	COG2226	methyltransferase
E2544_RS27855	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E2544_RS27860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E2544_RS27865	COG0569	domain protein
E2544_RS27870	COG2204	response regulator
E2544_RS27875	COG5000	phosphorelay sensor kinase activity
E2544_RS27885	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2544_RS27890	COG1280	lysine exporter protein (LysE YggA)
E2544_RS27900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2544_RS27910	COG1733	regulation of RNA biosynthetic process
E2544_RS27930	COG0546	phosphoglycolate phosphatase activity
E2544_RS27940	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E2544_RS27945	COG0242	peptide deformylase activity
E2544_RS27950	COG0758	DNA mediated transformation
E2544_RS27965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2544_RS27970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_RS27975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E2544_RS27990	COG1238	metal cluster binding
E2544_RS27995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2544_RS28000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2544_RS28015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E2544_RS28020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E2544_RS28025	COG4988	ABC transporter
E2544_RS28035	COG1294	oxidase, subunit
E2544_RS28040	COG1271	oxidase subunit
E2544_RS28050	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E2544_RS28060	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E2544_RS28075	COG1137	ATPase activity
E2544_RS28080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E2544_RS28090	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E2544_RS28095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_RS28110	COG1660	Displays ATPase and GTPase activities
E2544_RS28120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2544_RS28135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E2544_RS28140	COG2823	Periplasmic or secreted lipoprotein
E2544_RS28145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2544_RS28155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E2544_RS28165	COG1309	transcriptional regulator
E2544_RS28170	COG0471	metal ion transport
E2544_RS28175	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E2544_RS28180	COG0772	Belongs to the SEDS family
E2544_RS28185	COG0768	penicillin binding
E2544_RS28195	COG1792	Involved in formation and maintenance of cell shape
E2544_RS28200	COG1077	Cell shape determining protein MreB Mrl
E2544_RS28205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E2544_RS28210	COG0154	amidase activity
E2544_RS28215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E2544_RS28225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E2544_RS28230	COG0708	Exodeoxyribonuclease III
E2544_RS28245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E2544_RS28255	COG0583	DNA-binding transcription factor activity
E2544_RS28270	COG0583	DNA-binding transcription factor activity
E2544_RS28295	COG1764	response to oxidative stress
E2544_RS28300	COG1846	Transcriptional regulator
E2544_RS28345	COG0730	response to heat
E2544_RS28365	COG0640	Transcriptional regulator
E2544_RS28380	COG0456	acetyltransferase
E2544_RS28405	COG3189	MarR family transcriptional regulator
E2544_RS28410	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS28415	COG0352	thiamine-phosphate diphosphorylase activity
E2544_RS28415	COG0351	phosphomethylpyrimidine kinase
E2544_RS28415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E2544_RS28420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E2544_RS28425	COG0513	Belongs to the DEAD box helicase family
E2544_RS28435	COG0617	tRNA 3'-terminal CCA addition
E2544_RS28445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E2544_RS28450	COG2308	Evidence 4 Homologs of previously reported genes of
E2544_RS28460	COG1305	Transglutaminase-like
E2544_RS28490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2544_RS28495	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS28500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E2544_RS28505	COG1950	PFAM Membrane protein of
E2544_RS28510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E2544_RS28525	COG0596	Alpha beta hydrolase
E2544_RS28530	COG0066	3-isopropylmalate dehydratase activity
E2544_RS28540	COG3181	Tripartite tricarboxylate transporter family receptor
E2544_RS28545	COG0583	DNA-binding transcription factor activity
E2544_RS28550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2544_RS28590	COG0477	Major facilitator Superfamily
E2544_RS28595	COG0154	amidase activity
E2544_RS28600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E2544_RS28615	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E2544_RS28625	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E2544_RS28630	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E2544_RS28655	COG0735	belongs to the Fur family
E2544_RS28660	COG0523	cobalamin synthesis protein
E2544_RS28670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E2544_RS28675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E2544_RS28685	COG2096	Adenosyltransferase
E2544_RS28700	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E2544_RS28710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E2544_RS28725	COG0321	lipoyl(octanoyl) transferase activity
E2544_RS28740	COG1686	Belongs to the peptidase S11 family
E2544_RS28775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2544_RS28785	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E2544_RS28800	COG0859	PFAM glycosyl transferase family 9
E2544_RS28805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2544_RS28820	COG0438	transferase activity, transferring glycosyl groups
E2544_RS28825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E2544_RS28840	COG0297	glycogen (starch) synthase activity
E2544_RS28860	COG2076	Multidrug Resistance protein
E2544_RS28870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2544_RS28885	COG2814	Major facilitator Superfamily
E2544_RS28890	COG0697	spore germination
E2544_RS28900	COG3568	Endonuclease Exonuclease Phosphatase
E2544_RS28905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E2544_RS28935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2544_RS28950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2544_RS28965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2544_RS28970	COG1956	GAF domain-containing protein
E2544_RS28975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2544_RS29000	COG2186	Transcriptional regulator
E2544_RS29005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E2544_RS29040	COG2814	Major facilitator Superfamily
E2544_RS29055	COG0583	DNA-binding transcription factor activity
E2544_RS29065	COG1473	amidohydrolase
E2544_RS29070	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E2544_RS29075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E2544_RS29080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E2544_RS29090	COG1965	Belongs to the frataxin family
E2544_RS29100	COG0019	diaminopimelate decarboxylase activity
E2544_RS29220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2544_RS29225	COG1333	cytochrome c biogenesis protein
E2544_RS29235	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E2544_RS29265	COG0683	leucine binding
E2544_RS29270	COG1028	Short-chain dehydrogenase reductase Sdr
E2544_RS29275	COG1053	succinate dehydrogenase
E2544_RS29285	COG4232	protein-disulfide reductase activity
E2544_RS29290	COG1324	tolerance protein
E2544_RS29295	COG0537	adenosine 5'-monophosphoramidase activity
E2544_RS29300	COG0203	ribosomal protein L17
E2544_RS29305	COG0202	RNA polymerase activity
E2544_RS29310	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E2544_RS29315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E2544_RS29320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E2544_RS29325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E2544_RS29330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E2544_RS29335	COG0201	protein transport
E2544_RS29340	COG0200	Binds to the 23S rRNA
E2544_RS29345	COG1841	ribosomal large subunit assembly
E2544_RS29350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E2544_RS29355	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E2544_RS29360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E2544_RS29365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E2544_RS29370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E2544_RS29375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E2544_RS29380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E2544_RS29385	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E2544_RS29400	COG2207	Transcriptional regulator
E2544_RS29415	COG1137	ATPase activity
E2544_RS29420	COG1126	abc transporter atp-binding protein
E2544_RS29440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E2544_RS29445	COG0255	Belongs to the universal ribosomal protein uL29 family
E2544_RS29450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E2544_RS29455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E2544_RS29460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E2544_RS29465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E2544_RS29470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E2544_RS29475	COG0089	rRNA binding
E2544_RS29485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E2544_RS29490	COG0051	transcription antitermination factor activity, RNA binding
E2544_RS29495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2544_RS29500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2544_RS29505	COG0049	tRNA binding
E2544_RS29510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E2544_RS29515	COG0745	RESPONSE REGULATOR receiver
E2544_RS29530	COG5002	protein histidine kinase activity
E2544_RS29545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E2544_RS29550	COG0085	RNA polymerase activity
E2544_RS29555	COG0222	ribosome binding
E2544_RS29560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E2544_RS29565	COG0081	regulation of translation
E2544_RS29570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E2544_RS29580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2544_RS29590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E2544_RS29615	COG1012	belongs to the aldehyde dehydrogenase family
E2544_RS29630	COG1840	ABC-type Fe3 transport system, periplasmic component
E2544_RS29635	COG3842	ATPase activity
E2544_RS29645	COG1349	DNA-binding transcription factor activity
E2544_RS29670	COG0583	DNA-binding transcription factor activity
E2544_RS29675	COG0252	asparaginase activity
E2544_RS29680	COG1475	DNA binding
E2544_RS29690	COG1192	Involved in chromosome partitioning
E2544_RS29695	COG0357	Ribosomal RNA small subunit methyltransferase G
E2544_RS29700	COG0445	tRNA wobble uridine modification
E2544_RS29710	COG1278	Cold shock
E2544_RS29715	COG3180	Ammonia monooxygenase
E2544_RS29720	COG0436	Aminotransferase
E2544_RS29740	COG0642	Histidine kinase
E2544_RS29750	COG0038	chloride channel
E2544_RS29775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E2544_RS29785	COG0601	transmembrane transport
E2544_RS29790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2544_RS29795	COG0444	Belongs to the ABC transporter superfamily
E2544_RS29800	COG4608	Belongs to the ABC transporter superfamily
E2544_RS29805	COG1473	amidohydrolase
E2544_RS29810	COG2175	clavaminate synthase activity
E2544_RS29820	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E2544_RS29830	COG0753	catalase activity
E2544_RS29840	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E2544_RS29845	COG0594	ribonuclease P activity
E2544_RS29850	COG0230	Belongs to the bacterial ribosomal protein bL34 family