locus-tag	class	description
C2U31_RS00015	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2U31_RS00020	COG3639	organic phosphonate transmembrane transporter activity
C2U31_RS00025	COG3639	organic phosphonate transmembrane transporter activity
C2U31_RS00050	COG0742	ribosomal rna small subunit methyltransferase
C2U31_RS00055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2U31_RS00060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C2U31_RS00065	COG3135	benzoate transporter
C2U31_RS00095	COG0438	transferase activity, transferring glycosyl groups
C2U31_RS00100	COG0012	GTP binding
C2U31_RS00120	COG0193	aminoacyl-tRNA hydrolase activity
C2U31_RS00140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2U31_RS00145	COG0840	transmembrane signaling receptor activity
C2U31_RS00160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2U31_RS00195	COG0204	Acyl-transferase
C2U31_RS00200	COG1368	sulfuric ester hydrolase activity
C2U31_RS00205	COG2186	Transcriptional regulator
C2U31_RS00215	COG2205	protein histidine kinase activity
C2U31_RS00220	COG0745	RESPONSE REGULATOR receiver
C2U31_RS00225	COG0277	FAD linked oxidase domain protein
C2U31_RS00240	COG0166	Belongs to the GPI family
C2U31_RS00245	COG0438	transferase activity, transferring glycosyl groups
C2U31_RS00250	COG0438	transferase activity, transferring glycosyl groups
C2U31_RS00255	COG0438	transferase activity, transferring glycosyl groups
C2U31_RS00280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C2U31_RS00285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U31_RS00290	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C2U31_RS00300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C2U31_RS00315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS00320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2U31_RS00335	COG0747	negative chemotaxis
C2U31_RS00340	COG0601	transmembrane transport
C2U31_RS00345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS00350	COG4172	Belongs to the ABC transporter superfamily
C2U31_RS00355	COG0154	amidase activity
C2U31_RS00390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U31_RS00390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2U31_RS00395	COG0509	glycine decarboxylation via glycine cleavage system
C2U31_RS00400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U31_RS00415	COG2081	HI0933 family
C2U31_RS00430	COG0456	acetyltransferase
C2U31_RS00435	COG5001	Diguanylate cyclase
C2U31_RS00435	COG3706	GGDEF domain
C2U31_RS00435	COG2203	Gaf domain
C2U31_RS00435	COG4251	negative regulation of phosphorylation
C2U31_RS00445	COG0717	Belongs to the dCTP deaminase family
C2U31_RS00460	COG0489	protein tyrosine kinase activity
C2U31_RS00475	COG1054	Belongs to the UPF0176 family
C2U31_RS00490	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2U31_RS00490	COG2755	lipolytic protein G-D-S-L family
C2U31_RS00505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U31_RS00530	COG2200	EAL domain
C2U31_RS00550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_RS00555	COG0842	Transport permease protein
C2U31_RS00555	COG1129	ABC transporter
C2U31_RS00560	COG0842	Transport permease protein
C2U31_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS00580	COG0697	spore germination
C2U31_RS00590	COG1271	oxidase subunit
C2U31_RS00595	COG1294	oxidase, subunit
C2U31_RS00605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS00610	COG3258	Cytochrome c
C2U31_RS00620	COG0625	glutathione transferase activity
C2U31_RS00665	COG0165	Argininosuccinate lyase
C2U31_RS00670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U31_RS00680	COG0583	DNA-binding transcription factor activity
C2U31_RS00685	COG0235	Class ii aldolase
C2U31_RS00690	COG0477	Major facilitator Superfamily
C2U31_RS00730	COG0457	Tetratricopeptide repeat
C2U31_RS00735	COG0438	transferase activity, transferring glycosyl groups
C2U31_RS00740	COG1596	polysaccharide export
C2U31_RS00760	COG4783	chaperone-mediated protein folding
C2U31_RS00760	COG1560	Kdo2-lipid A biosynthetic process
C2U31_RS00765	COG3866	Pectate lyase
C2U31_RS00770	COG0583	DNA-binding transcription factor activity
C2U31_RS00775	COG2814	Major facilitator Superfamily
C2U31_RS00820	COG0583	DNA-binding transcription factor activity
C2U31_RS00825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U31_RS00830	COG0501	Belongs to the peptidase M48B family
C2U31_RS00875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U31_RS00885	COG0542	response to heat
C2U31_RS00890	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U31_RS00910	COG0583	DNA-binding transcription factor activity
C2U31_RS00925	COG1192	Involved in chromosome partitioning
C2U31_RS01105	COG3039	Transposase
C2U31_RS01180	COG2003	Belongs to the UPF0758 family
C2U31_RS01240	COG0582	viral genome integration into host DNA
C2U31_RS01280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_RS01285	COG0583	DNA-binding transcription factor activity
C2U31_RS01290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2U31_RS01310	COG1652	LysM domain
C2U31_RS01315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2U31_RS01335	COG0625	glutathione transferase activity
C2U31_RS01340	COG1414	Transcriptional regulator
C2U31_RS01345	COG3734	2-keto-3-deoxy-galactonokinase
C2U31_RS01350	COG0800	Aldolase
C2U31_RS01355	COG4948	Mandelate Racemase Muconate Lactonizing
C2U31_RS01360	COG2271	Major facilitator Superfamily
C2U31_RS01365	COG2814	Major facilitator Superfamily
C2U31_RS01370	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C2U31_RS01375	COG1518	maintenance of DNA repeat elements
C2U31_RS01405	COG0326	Molecular chaperone. Has ATPase activity
C2U31_RS01420	COG2233	PERMEase
C2U31_RS01430	COG2026	Addiction module toxin, RelE StbE family
C2U31_RS01445	COG5499	transcription regulator containing HTH domain
C2U31_RS01450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS01455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_RS01465	COG1132	(ABC) transporter
C2U31_RS01465	COG2375	cellular response to nickel ion
C2U31_RS01470	COG1132	(ABC) transporter
C2U31_RS01475	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_RS01480	COG4605	iron ion homeostasis
C2U31_RS01485	COG4604	ABC transporter, ATP-binding protein
C2U31_RS01490	COG4607	ABC-type enterochelin transport system periplasmic component
C2U31_RS01495	COG4774	siderophore transport
C2U31_RS01585	COG3846	protein secretion by the type IV secretion system
C2U31_RS01600	COG3451	type IV secretory pathway VirB4
C2U31_RS01610	COG3838	Conjugal transfer protein Trbc
C2U31_RS01615	COG4962	Type ii secretion system protein e
C2U31_RS01645	COG2076	Multidrug Resistance protein
C2U31_RS01655	COG0583	DNA-binding transcription factor activity
C2U31_RS01690	COG2003	Belongs to the UPF0758 family
C2U31_RS01695	COG4804	nuclease activity
C2U31_RS01770	COG1695	Transcriptional regulator
C2U31_RS01790	COG0477	Major facilitator Superfamily
C2U31_RS01810	COG1090	epimerase
C2U31_RS01820	COG0628	permease
C2U31_RS01825	COG0583	DNA-binding transcription factor activity
C2U31_RS01830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_RS01855	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
C2U31_RS01880	COG2186	Transcriptional regulator
C2U31_RS01890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U31_RS01920	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS01925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2U31_RS01935	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U31_RS01940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U31_RS01945	COG0656	L-ascorbic acid biosynthetic process
C2U31_RS01950	COG0583	DNA-binding transcription factor activity
C2U31_RS01960	COG0667	Aldo Keto reductase
C2U31_RS01965	COG0583	DNA-binding transcription factor activity
C2U31_RS01975	COG0625	glutathione transferase activity
C2U31_RS01985	COG0129	dihydroxy-acid dehydratase activity
C2U31_RS02010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2U31_RS02015	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2U31_RS02020	COG1802	Transcriptional regulator
C2U31_RS02035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_RS02055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_RS02060	COG0778	Nitroreductase
C2U31_RS02070	COG0583	DNA-binding transcription factor activity
C2U31_RS02085	COG1595	DNA-templated transcription, initiation
C2U31_RS02090	COG3712	iron ion homeostasis
C2U31_RS02095	COG4774	siderophore transport
C2U31_RS02105	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_RS02110	COG2031	fatty acid transporter
C2U31_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS02120	COG1414	Transcriptional regulator
C2U31_RS02130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U31_RS02135	COG4829	muconolactone delta-isomerase
C2U31_RS02145	COG0596	Alpha beta hydrolase
C2U31_RS02165	COG0288	reversible hydration of carbon dioxide
C2U31_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS02220	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS02250	COG1053	succinate dehydrogenase
C2U31_RS02255	COG0625	glutathione transferase activity
C2U31_RS02285	COG0583	DNA-binding transcription factor activity
C2U31_RS02310	COG1464	Belongs to the NlpA lipoprotein family
C2U31_RS02325	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C2U31_RS02330	COG1309	transcriptional regulator
C2U31_RS02335	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U31_RS02340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2U31_RS02395	COG0583	DNA-binding transcription factor activity
C2U31_RS02405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C2U31_RS02415	COG1053	succinate dehydrogenase
C2U31_RS02435	COG1522	sequence-specific DNA binding
C2U31_RS02445	COG5006	permease, DMT superfamily
C2U31_RS02450	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS02455	COG3622	Belongs to the hyi family
C2U31_RS02490	COG0747	negative chemotaxis
C2U31_RS02495	COG0601	transmembrane transport
C2U31_RS02500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS02505	COG0444	Belongs to the ABC transporter superfamily
C2U31_RS02510	COG4608	Belongs to the ABC transporter superfamily
C2U31_RS02515	COG0583	DNA-binding transcription factor activity
C2U31_RS02520	COG2186	Transcriptional regulator
C2U31_RS02525	COG3395	kinase activity
C2U31_RS02530	COG2084	Dehydrogenase
C2U31_RS02535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U31_RS02540	COG3622	Belongs to the hyi family
C2U31_RS02545	COG2271	Major facilitator Superfamily
C2U31_RS02550	COG0235	Class ii aldolase
C2U31_RS02565	COG1802	Transcriptional regulator
C2U31_RS02570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_RS02600	COG0142	geranyltranstransferase activity
C2U31_RS02610	COG1414	Transcriptional regulator
C2U31_RS02615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2U31_RS02620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2U31_RS02625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2U31_RS02630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2U31_RS02645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U31_RS02665	COG5001	Diguanylate cyclase
C2U31_RS02670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2U31_RS02675	COG0793	Belongs to the peptidase S41A family
C2U31_RS02680	COG4942	peptidase
C2U31_RS02685	COG0588	phosphoglycerate mutase activity
C2U31_RS02690	COG1054	Belongs to the UPF0176 family
C2U31_RS02695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U31_RS02700	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C2U31_RS02705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2U31_RS02720	COG1040	competence protein
C2U31_RS02725	COG2226	methyltransferase
C2U31_RS02730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C2U31_RS02735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2U31_RS02740	COG0569	domain protein
C2U31_RS02745	COG2204	response regulator
C2U31_RS02750	COG5000	phosphorelay sensor kinase activity
C2U31_RS02760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U31_RS02760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U31_RS02765	COG3188	usher protein
C2U31_RS02770	COG3121	Chaperone
C2U31_RS02800	COG2197	response regulator
C2U31_RS02805	COG2205	protein histidine kinase activity
C2U31_RS02805	COG0784	Response regulator, receiver
C2U31_RS02810	COG3300	MHYT domain
C2U31_RS02810	COG5001	Diguanylate cyclase
C2U31_RS02820	COG1280	lysine exporter protein (LysE YggA)
C2U31_RS02835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U31_RS02845	COG1733	regulation of RNA biosynthetic process
C2U31_RS02860	COG0546	phosphoglycolate phosphatase activity
C2U31_RS02880	COG0242	peptide deformylase activity
C2U31_RS02885	COG0758	DNA mediated transformation
C2U31_RS02900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS02905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS02910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2U31_RS02915	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS02920	COG2032	superoxide dismutase activity
C2U31_RS02935	COG1238	metal cluster binding
C2U31_RS02940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U31_RS02945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_RS02965	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2U31_RS02970	COG4988	ABC transporter
C2U31_RS02980	COG1294	oxidase, subunit
C2U31_RS02995	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2U31_RS03005	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C2U31_RS03020	COG1137	ATPase activity
C2U31_RS03025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2U31_RS03035	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2U31_RS03040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS03055	COG1660	Displays ATPase and GTPase activities
C2U31_RS03065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U31_RS03080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C2U31_RS03085	COG2823	Periplasmic or secreted lipoprotein
C2U31_RS03090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_RS03100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U31_RS03110	COG1309	transcriptional regulator
C2U31_RS03115	COG0471	metal ion transport
C2U31_RS03120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2U31_RS03140	COG0772	Belongs to the SEDS family
C2U31_RS03145	COG0768	penicillin binding
C2U31_RS03155	COG1792	Involved in formation and maintenance of cell shape
C2U31_RS03160	COG1077	Cell shape determining protein MreB Mrl
C2U31_RS03165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2U31_RS03170	COG0154	amidase activity
C2U31_RS03175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2U31_RS03195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2U31_RS03200	COG0708	Exodeoxyribonuclease III
C2U31_RS03205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U31_RS03215	COG0583	DNA-binding transcription factor activity
C2U31_RS03250	COG1764	response to oxidative stress
C2U31_RS03255	COG1846	Transcriptional regulator
C2U31_RS03300	COG0730	response to heat
C2U31_RS03320	COG0640	Transcriptional regulator
C2U31_RS03355	COG3189	MarR family transcriptional regulator
C2U31_RS03380	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2U31_RS03385	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2U31_RS03385	COG0352	thiamine-phosphate diphosphorylase activity
C2U31_RS03385	COG0351	phosphomethylpyrimidine kinase
C2U31_RS03390	COG2226	methyltransferase
C2U31_RS03400	COG3210	domain, Protein
C2U31_RS03400	COG3210	domain, Protein
C2U31_RS03405	COG2831	hemolysin activation secretion protein
C2U31_RS03410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2U31_RS03415	COG0513	Belongs to the DEAD box helicase family
C2U31_RS03425	COG0477	Major facilitator Superfamily
C2U31_RS03455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2U31_RS03460	COG2308	Evidence 4 Homologs of previously reported genes of
C2U31_RS03470	COG1305	Transglutaminase-like
C2U31_RS03480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2U31_RS03485	COG1950	PFAM Membrane protein of
C2U31_RS03490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C2U31_RS03495	COG0438	transferase activity, transferring glycosyl groups
C2U31_RS03520	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U31_RS03530	COG1301	dicarboxylic acid transport
C2U31_RS03540	COG1027	Aspartate ammonia-lyase
C2U31_RS03545	COG0596	Alpha beta hydrolase
C2U31_RS03555	COG0477	Major facilitator Superfamily
C2U31_RS03560	COG0154	amidase activity
C2U31_RS03600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2U31_RS03615	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2U31_RS03625	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C2U31_RS03630	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C2U31_RS03640	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2U31_RS03655	COG0735	belongs to the Fur family
C2U31_RS03660	COG0523	cobalamin synthesis protein
C2U31_RS03670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2U31_RS03675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2U31_RS03685	COG2096	Adenosyltransferase
C2U31_RS03780	COG1215	transferase activity, transferring glycosyl groups
C2U31_RS03810	COG0110	maltose O-acetyltransferase activity
C2U31_RS03820	COG0529	Catalyzes the synthesis of activated sulfate
C2U31_RS03835	COG0574	Belongs to the PEP-utilizing enzyme family
C2U31_RS03835	COG3848	Pyruvate phosphate dikinase
C2U31_RS03840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2U31_RS03850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2U31_RS03855	COG1609	Transcriptional regulator
C2U31_RS03865	COG0321	lipoyl(octanoyl) transferase activity
C2U31_RS03870	COG2921	Belongs to the UPF0250 family
C2U31_RS03880	COG1686	Belongs to the peptidase S11 family
C2U31_RS03905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U31_RS03915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2U31_RS03925	COG0859	PFAM glycosyl transferase family 9
C2U31_RS03935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2U31_RS03945	COG1215	transferase activity, transferring glycosyl groups
C2U31_RS03950	COG0562	UDP-galactopyranose mutase
C2U31_RS03980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U31_RS03990	COG2814	Major facilitator Superfamily
C2U31_RS03995	COG0697	spore germination
C2U31_RS04000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U31_RS04005	COG3568	Endonuclease Exonuclease Phosphatase
C2U31_RS04010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2U31_RS04035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U31_RS04050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_RS04055	COG1956	GAF domain-containing protein
C2U31_RS04060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS04085	COG2186	Transcriptional regulator
C2U31_RS04135	COG2814	Major facilitator Superfamily
C2U31_RS04150	COG0583	DNA-binding transcription factor activity
C2U31_RS04160	COG1473	amidohydrolase
C2U31_RS04165	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C2U31_RS04170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2U31_RS04175	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2U31_RS04185	COG1965	Belongs to the frataxin family
C2U31_RS04195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2U31_RS04200	COG1333	cytochrome c biogenesis protein
C2U31_RS04210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2U31_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS04250	COG1053	succinate dehydrogenase
C2U31_RS04260	COG4232	protein-disulfide reductase activity
C2U31_RS04265	COG1324	tolerance protein
C2U31_RS04275	COG0203	ribosomal protein L17
C2U31_RS04280	COG0202	RNA polymerase activity
C2U31_RS04285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2U31_RS04290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2U31_RS04295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2U31_RS04300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2U31_RS04305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U31_RS04310	COG0201	protein transport
C2U31_RS04315	COG0200	Binds to the 23S rRNA
C2U31_RS04320	COG1841	ribosomal large subunit assembly
C2U31_RS04325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2U31_RS04330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2U31_RS04335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2U31_RS04340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2U31_RS04345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2U31_RS04350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2U31_RS04355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C2U31_RS04360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2U31_RS04385	COG2207	Transcriptional regulator
C2U31_RS04430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2U31_RS04435	COG0255	Belongs to the universal ribosomal protein uL29 family
C2U31_RS04440	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2U31_RS04445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2U31_RS04450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2U31_RS04455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2U31_RS04460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2U31_RS04465	COG0089	rRNA binding
C2U31_RS04475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2U31_RS04480	COG0051	transcription antitermination factor activity, RNA binding
C2U31_RS04485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U31_RS04490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U31_RS04495	COG0049	tRNA binding
C2U31_RS04500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2U31_RS04505	COG0745	RESPONSE REGULATOR receiver
C2U31_RS04535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2U31_RS04540	COG0085	RNA polymerase activity
C2U31_RS04545	COG0222	ribosome binding
C2U31_RS04550	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2U31_RS04555	COG0081	regulation of translation
C2U31_RS04560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C2U31_RS04570	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U31_RS04580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2U31_RS04605	COG1349	DNA-binding transcription factor activity
C2U31_RS04610	COG0252	asparaginase activity
C2U31_RS04615	COG1475	DNA binding
C2U31_RS04625	COG1192	Involved in chromosome partitioning
C2U31_RS04630	COG0357	Ribosomal RNA small subunit methyltransferase G
C2U31_RS04635	COG0445	tRNA wobble uridine modification
C2U31_RS04640	COG1278	Cold shock
C2U31_RS04645	COG3180	Ammonia monooxygenase
C2U31_RS04650	COG0436	Aminotransferase
C2U31_RS04685	COG0038	chloride channel
C2U31_RS04690	COG0583	DNA-binding transcription factor activity
C2U31_RS04695	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2U31_RS04700	COG0511	ligase activity, forming carbon-carbon bonds
C2U31_RS04705	COG0439	Biotin carboxylase
C2U31_RS04715	COG1984	allophanate hydrolase subunit 2
C2U31_RS04725	COG2207	Transcriptional regulator
C2U31_RS04740	COG1113	amino acid transport
C2U31_RS04755	COG0436	Aminotransferase
C2U31_RS04760	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_RS04765	COG0277	FAD linked oxidase domain protein
C2U31_RS04770	COG2271	Major facilitator Superfamily
C2U31_RS04785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_RS04790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U31_RS04800	COG1279	arginine transmembrane transporter activity
C2U31_RS04820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2U31_RS04830	COG0601	transmembrane transport
C2U31_RS04835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS04840	COG0444	Belongs to the ABC transporter superfamily
C2U31_RS04845	COG4608	Belongs to the ABC transporter superfamily
C2U31_RS04850	COG1473	amidohydrolase
C2U31_RS04855	COG2175	clavaminate synthase activity
C2U31_RS04865	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U31_RS04875	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C2U31_RS04880	COG2205	protein histidine kinase activity
C2U31_RS04885	COG0740	serine-type endopeptidase activity
C2U31_RS04905	COG0706	membrane insertase activity
C2U31_RS04910	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2U31_RS04915	COG0594	ribonuclease P activity
C2U31_RS04920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2U31_RS04925	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2U31_RS04930	COG0592	DNA-directed DNA polymerase activity
C2U31_RS04950	COG0583	DNA-binding transcription factor activity
C2U31_RS04965	COG1741	Belongs to the pirin family
C2U31_RS04975	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2U31_RS05000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS05005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U31_RS05015	COG1414	Transcriptional regulator
C2U31_RS05020	COG1024	Enoyl-CoA hydratase
C2U31_RS05030	COG3842	ATPase activity
C2U31_RS05035	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U31_RS05050	COG1126	abc transporter atp-binding protein
C2U31_RS05055	COG0154	amidase activity
C2U31_RS05060	COG1917	Cupin 2, conserved barrel domain protein
C2U31_RS05085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U31_RS05090	COG0583	DNA-binding transcription factor activity
C2U31_RS05095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS05100	COG0765	amino acid transport
C2U31_RS05105	COG0765	amino acid transport
C2U31_RS05110	COG1126	abc transporter atp-binding protein
C2U31_RS05135	COG1304	FMN binding
C2U31_RS05150	COG0402	S-adenosylhomocysteine deaminase activity
C2U31_RS05160	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2U31_RS05165	COG3845	ABC transporter
C2U31_RS05180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2U31_RS05195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U31_RS05205	COG0436	Aminotransferase
C2U31_RS05210	COG1126	abc transporter atp-binding protein
C2U31_RS05215	COG0765	amino acid transport
C2U31_RS05220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS05240	COG2084	Dehydrogenase
C2U31_RS05245	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS05255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2U31_RS05265	COG3781	membrane
C2U31_RS05270	COG1522	sequence-specific DNA binding
C2U31_RS05275	COG0028	Belongs to the TPP enzyme family
C2U31_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS05285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS05290	COG1116	anion transmembrane transporter activity
C2U31_RS05300	COG0551	DNA topoisomerase type I activity
C2U31_RS05300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U31_RS05310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U31_RS05315	COG2922	Belongs to the Smg family
C2U31_RS05335	COG2358	TRAP transporter, solute receptor (TAXI family
C2U31_RS05380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U31_RS05425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS05445	COG0583	DNA-binding transcription factor activity
C2U31_RS05455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS05480	COG0477	Major facilitator Superfamily
C2U31_RS05510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2U31_RS05515	COG0183	Belongs to the thiolase family
C2U31_RS05520	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C2U31_RS05525	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS05530	COG1473	amidohydrolase
C2U31_RS05540	COG1742	UPF0060 membrane protein
C2U31_RS05555	COG1280	lysine exporter protein (LysE YggA)
C2U31_RS05575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2U31_RS05585	COG0018	arginyl-trna synthetase
C2U31_RS05600	COG2186	Transcriptional regulator
C2U31_RS05605	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C2U31_RS05615	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS05620	COG0395	ABC-type sugar transport system, permease component
C2U31_RS05625	COG1175	transmembrane transport
C2U31_RS05630	COG1653	transport
C2U31_RS05640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U31_RS05645	COG1609	Transcriptional regulator
C2U31_RS05655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2U31_RS05670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2U31_RS05680	COG0583	DNA-binding transcription factor activity
C2U31_RS05685	COG0697	spore germination
C2U31_RS05700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C2U31_RS05710	COG0513	Belongs to the DEAD box helicase family
C2U31_RS05715	COG5339	Protein conserved in bacteria
C2U31_RS05720	COG1228	amidohydrolase
C2U31_RS05730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS05735	COG0601	transmembrane transport
C2U31_RS05740	COG0747	negative chemotaxis
C2U31_RS05745	COG1160	GTP binding
C2U31_RS05760	COG0697	spore germination
C2U31_RS05775	COG0583	DNA-binding transcription factor activity
C2U31_RS05790	COG2969	positive regulation of protein catabolic process
C2U31_RS05795	COG0625	glutathione transferase activity
C2U31_RS05800	COG2857	Cytochrome c1
C2U31_RS05805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2U31_RS05810	COG0723	plastoquinol--plastocyanin reductase activity
C2U31_RS05815	COG1970	mechanosensitive ion channel activity
C2U31_RS05820	COG0235	Class ii aldolase
C2U31_RS05830	COG0477	Major facilitator Superfamily
C2U31_RS05840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2U31_RS05845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U31_RS05860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U31_RS05865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2U31_RS05870	COG0537	adenosine 5'-monophosphoramidase activity
C2U31_RS05875	COG0140	phosphoribosyl-ATP diphosphatase activity
C2U31_RS05880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2U31_RS05885	COG0107	imidazoleglycerol-phosphate synthase activity
C2U31_RS05890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2U31_RS05900	COG0131	Imidazoleglycerol-phosphate dehydratase
C2U31_RS05905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U31_RS05910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2U31_RS05920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2U31_RS05930	COG0842	Transport permease protein
C2U31_RS05935	COG1131	(ABC) transporter
C2U31_RS05945	COG2853	Lipoprotein
C2U31_RS05950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C2U31_RS05955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C2U31_RS05960	COG1127	ABC transporter
C2U31_RS05975	COG0477	Major facilitator Superfamily
C2U31_RS05985	COG3047	cAMP biosynthetic process
C2U31_RS05995	COG0070	glutamate synthase
C2U31_RS05995	COG0067	glutamate synthase
C2U31_RS05995	COG0069	glutamate synthase activity
C2U31_RS06020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U31_RS06040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U31_RS06070	COG1612	heme a metabolic process
C2U31_RS06080	COG1999	signal sequence binding
C2U31_RS06100	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2U31_RS06105	COG2814	Major facilitator Superfamily
C2U31_RS06125	COG1522	sequence-specific DNA binding
C2U31_RS06165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U31_RS06170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_RS06175	COG4166	transmembrane transport
C2U31_RS06185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS06200	COG0667	Aldo Keto reductase
C2U31_RS06215	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2U31_RS06220	COG4608	Belongs to the ABC transporter superfamily
C2U31_RS06225	COG0444	Belongs to the ABC transporter superfamily
C2U31_RS06235	COG0601	transmembrane transport
C2U31_RS06240	COG0747	negative chemotaxis
C2U31_RS06250	COG0251	oxidation-reduction process
C2U31_RS06260	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2U31_RS06305	COG1487	ribonuclease activity
C2U31_RS06310	COG0840	transmembrane signaling receptor activity
C2U31_RS06315	COG5001	Diguanylate cyclase
C2U31_RS06320	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2U31_RS06335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2U31_RS06340	COG0583	DNA-binding transcription factor activity
C2U31_RS06345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U31_RS06355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U31_RS06360	COG0463	Glycosyl transferase, family 2
C2U31_RS06400	COG0737	Belongs to the 5'-nucleotidase family
C2U31_RS06430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2U31_RS06450	COG0840	transmembrane signaling receptor activity
C2U31_RS06530	COG1464	Belongs to the NlpA lipoprotein family
C2U31_RS06535	COG0431	NADPH-dependent FMN reductase
C2U31_RS06540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U31_RS06545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_RS06550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS06560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U31_RS06565	COG2011	ABC-type metal ion transport system permease component
C2U31_RS06570	COG1464	Belongs to the NlpA lipoprotein family
C2U31_RS06575	COG1116	anion transmembrane transporter activity
C2U31_RS06580	COG3585	molybdate ion transport
C2U31_RS06605	COG3119	arylsulfatase activity
C2U31_RS06610	COG0583	DNA-binding transcription factor activity
C2U31_RS06615	COG1607	acyl-coa hydrolase
C2U31_RS06625	COG0477	Major facilitator Superfamily
C2U31_RS06630	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS06635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_RS06640	COG0243	molybdopterin cofactor binding
C2U31_RS06640	COG3383	formate dehydrogenase (NAD+) activity
C2U31_RS06645	COG0243	molybdopterin cofactor binding
C2U31_RS06645	COG3383	formate dehydrogenase (NAD+) activity
C2U31_RS06650	COG0437	4 iron, 4 sulfur cluster binding
C2U31_RS06655	COG2864	formate dehydrogenase
C2U31_RS06660	COG3058	Necessary for formate dehydrogenase activity
C2U31_RS06670	COG3276	selenocysteine insertion sequence binding
C2U31_RS06680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_RS06685	COG1305	Transglutaminase-like
C2U31_RS06720	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_RS06725	COG3284	Transcriptional regulator
C2U31_RS06740	COG0512	Glutamine amidotransferase of anthranilate synthase
C2U31_RS06750	COG0546	phosphoglycolate phosphatase activity
C2U31_RS06755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2U31_RS06760	COG2967	ApaG domain
C2U31_RS06765	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C2U31_RS06770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U31_RS06805	COG0583	DNA-binding transcription factor activity
C2U31_RS06815	COG1024	Enoyl-CoA hydratase
C2U31_RS06830	COG0356	it plays a direct role in the translocation of protons across the membrane
C2U31_RS06845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2U31_RS06850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2U31_RS06855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2U31_RS06865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2U31_RS06875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2U31_RS06880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2U31_RS06885	COG0210	DNA helicase
C2U31_RS06900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2U31_RS06905	COG2171	N-acyltransferase activity
C2U31_RS06910	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2U31_RS06920	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2U31_RS06930	COG4608	Belongs to the ABC transporter superfamily
C2U31_RS06935	COG0444	Belongs to the ABC transporter superfamily
C2U31_RS06940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS06945	COG0601	transmembrane transport
C2U31_RS06950	COG0747	negative chemotaxis
C2U31_RS06955	COG2988	succinylglutamate desuccinylase activity
C2U31_RS06965	COG0583	DNA-binding transcription factor activity
C2U31_RS06970	COG0747	negative chemotaxis
C2U31_RS06980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2U31_RS06985	COG1024	Enoyl-CoA hydratase
C2U31_RS07000	COG1309	transcriptional regulator
C2U31_RS07015	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_RS07055	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U31_RS07075	COG1129	ABC transporter
C2U31_RS07090	COG1802	Transcriptional regulator
C2U31_RS07110	COG2918	glutathione biosynthetic process
C2U31_RS07125	COG2197	response regulator
C2U31_RS07135	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2U31_RS07140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_RS07150	COG2721	sulfolactate sulfo-lyase activity
C2U31_RS07155	COG2721	sulfolactate sulfo-lyase activity
C2U31_RS07160	COG2188	Transcriptional regulator
C2U31_RS07165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U31_RS07170	COG2813	Specifically methylates the guanine in position
C2U31_RS07170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U31_RS07175	COG2223	nitrite transmembrane transporter activity
C2U31_RS07185	COG2860	membrane
C2U31_RS07190	COG1802	Transcriptional regulator
C2U31_RS07200	COG1984	allophanate hydrolase subunit 2
C2U31_RS07205	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2U31_RS07220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_RS07235	COG2132	Multicopper oxidase
C2U31_RS07240	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
C2U31_RS07245	COG0642	Histidine kinase
C2U31_RS07260	COG0745	RESPONSE REGULATOR receiver
C2U31_RS07265	COG2226	methyltransferase
C2U31_RS07280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2U31_RS07290	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2U31_RS07305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U31_RS07310	COG0351	phosphomethylpyrimidine kinase
C2U31_RS07315	COG2022	thiamine diphosphate biosynthetic process
C2U31_RS07320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U31_RS07325	COG4771	TonB-dependent receptor
C2U31_RS07340	COG2186	Transcriptional regulator
C2U31_RS07350	COG2177	Part of the ABC transporter FtsEX involved in
C2U31_RS07355	COG2884	Cell division ATP-binding protein ftsE
C2U31_RS07360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS07365	COG4597	amino acid ABC transporter
C2U31_RS07370	COG0765	amino acid transport
C2U31_RS07375	COG1126	abc transporter atp-binding protein
C2U31_RS07385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_RS07390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_RS07410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U31_RS07415	COG2081	HI0933 family
C2U31_RS07425	COG0077	Prephenate dehydratase
C2U31_RS07425	COG1605	Chorismate mutase
C2U31_RS07460	COG0477	Major facilitator Superfamily
C2U31_RS07470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2U31_RS07475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2U31_RS07480	COG4566	intracellular signal transduction
C2U31_RS07495	COG0237	dephospho-CoA kinase activity
C2U31_RS07500	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C2U31_RS07510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_RS07515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_RS07525	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS07530	COG0583	DNA-binding transcription factor activity
C2U31_RS07540	COG0154	amidase activity
C2U31_RS07550	COG0583	DNA-binding transcription factor activity
C2U31_RS07600	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2U31_RS07630	COG1129	ABC transporter
C2U31_RS07660	COG2202	Pas domain
C2U31_RS07660	COG2199	diguanylate cyclase activity
C2U31_RS07660	COG2200	EAL domain
C2U31_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS07675	COG1024	Enoyl-CoA hydratase
C2U31_RS07715	COG4638	Rieske (2fe-2S)
C2U31_RS07720	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U31_RS07725	COG1335	isochorismatase
C2U31_RS07730	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS07740	COG0741	lytic transglycosylase activity
C2U31_RS07745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U31_RS07750	COG0352	thiamine-phosphate diphosphorylase activity
C2U31_RS07765	COG1678	Uncharacterized ACR, COG1678
C2U31_RS07770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2U31_RS07795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U31_RS07800	COG0436	Aminotransferase
C2U31_RS07805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS07815	COG0765	amino acid transport
C2U31_RS07820	COG1126	abc transporter atp-binding protein
C2U31_RS07835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2U31_RS07840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U31_RS07850	COG3842	ATPase activity
C2U31_RS07855	COG1175	transmembrane transport
C2U31_RS07885	COG0557	exoribonuclease II activity
C2U31_RS07890	COG3150	esterase
C2U31_RS07895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U31_RS07900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_RS07905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2U31_RS07910	COG0511	ligase activity, forming carbon-carbon bonds
C2U31_RS07915	COG0439	Biotin carboxylase
C2U31_RS07920	COG2264	protein methyltransferase activity
C2U31_RS07955	COG1696	Membrane protein involved in D-alanine export
C2U31_RS08000	COG2814	Major facilitator Superfamily
C2U31_RS08010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U31_RS08015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U31_RS08015	COG1042	CoA-binding domain protein
C2U31_RS08015	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U31_RS08025	COG3028	Belongs to the UPF0307 family
C2U31_RS08030	COG0312	modulator of DNA gyrase
C2U31_RS08035	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C2U31_RS08045	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_RS08065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2U31_RS08070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2U31_RS08075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U31_RS08085	COG0316	Belongs to the HesB IscA family
C2U31_RS08100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2U31_RS08105	COG1881	PFAM PEBP family protein
C2U31_RS08110	COG1280	lysine exporter protein (LysE YggA)
C2U31_RS08115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U31_RS08120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2U31_RS08130	COG1335	isochorismatase
C2U31_RS08135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U31_RS08135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2U31_RS08150	COG2766	serine protein kinase
C2U31_RS08155	COG2718	Belongs to the UPF0229 family
C2U31_RS08160	COG2719	SpoVR family
C2U31_RS08195	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS08200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C2U31_RS08205	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2U31_RS08225	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS08260	COG2070	2-Nitropropane dioxygenase
C2U31_RS08280	COG0840	transmembrane signaling receptor activity
C2U31_RS08305	COG0741	lytic transglycosylase activity
C2U31_RS08305	COG1388	LysM domain
C2U31_RS08310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2U31_RS08315	COG2226	methyltransferase
C2U31_RS08320	COG0328	RNA-DNA hybrid ribonuclease activity
C2U31_RS08330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_RS08335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2U31_RS08350	COG1671	Belongs to the UPF0178 family
C2U31_RS08360	COG2358	TRAP transporter, solute receptor (TAXI family
C2U31_RS08365	COG0786	glutamate:sodium symporter activity
C2U31_RS08375	COG0463	Glycosyl transferase, family 2
C2U31_RS08380	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2U31_RS08395	COG0583	DNA-binding transcription factor activity
C2U31_RS08410	COG0583	DNA-binding transcription factor activity
C2U31_RS08420	COG1346	cytolysis
C2U31_RS08430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS08445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2U31_RS08455	COG1522	sequence-specific DNA binding
C2U31_RS08460	COG2267	carboxylic ester hydrolase activity
C2U31_RS08470	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
C2U31_RS08475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_RS08490	COG0823	Involved in the tonB-independent uptake of proteins
C2U31_RS08500	COG0848	biopolymer transport protein
C2U31_RS08505	COG0811	peptide transport
C2U31_RS08510	COG0824	Thioesterase
C2U31_RS08515	COG0442	prolyl-tRNA aminoacylation
C2U31_RS08535	COG3842	ATPase activity
C2U31_RS08540	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U31_RS08560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U31_RS08565	COG0583	DNA-binding transcription factor activity
C2U31_RS08585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_RS08600	COG2084	Dehydrogenase
C2U31_RS08645	COG0129	dihydroxy-acid dehydratase activity
C2U31_RS08650	COG4654	Cytochrome c, class I
C2U31_RS08655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U31_RS08665	COG1522	sequence-specific DNA binding
C2U31_RS08705	COG1473	amidohydrolase
C2U31_RS08710	COG0418	dihydroorotase activity
C2U31_RS08715	COG0488	(ABC) transporter
C2U31_RS08725	COG2001	Belongs to the MraZ family
C2U31_RS08730	COG0275	rRNA processing
C2U31_RS08735	COG3116	cell division
C2U31_RS08745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U31_RS08750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2U31_RS08755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2U31_RS08765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2U31_RS08770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2U31_RS08775	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U31_RS08780	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2U31_RS08795	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C2U31_RS08805	COG0739	heme binding
C2U31_RS08810	COG0653	protein targeting
C2U31_RS08825	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS08830	COG0028	Belongs to the TPP enzyme family
C2U31_RS08840	COG0300	oxidoreductase activity
C2U31_RS08845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_RS08850	COG1522	sequence-specific DNA binding
C2U31_RS08865	COG2239	Acts as a magnesium transporter
C2U31_RS08875	COG2855	membrane
C2U31_RS08885	COG1473	amidohydrolase
C2U31_RS08890	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_RS08900	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C2U31_RS08900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_RS08905	COG1501	Belongs to the glycosyl hydrolase 31 family
C2U31_RS08910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U31_RS08915	COG2011	ABC-type metal ion transport system permease component
C2U31_RS08940	COG0735	belongs to the Fur family
C2U31_RS08960	COG2818	Glycosylase
C2U31_RS08965	COG1368	sulfuric ester hydrolase activity
C2U31_RS08970	COG2982	Protein involved in outer membrane biogenesis
C2U31_RS08980	COG1309	transcriptional regulator
C2U31_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS09005	COG0473	3-isopropylmalate dehydrogenase activity
C2U31_RS09020	COG2154	pterin-4-alpha-carbinolamine dehydratase
C2U31_RS09030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2U31_RS09045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_RS09050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2U31_RS09055	COG1929	Belongs to the glycerate kinase type-1 family
C2U31_RS09060	COG0469	pyruvate kinase activity
C2U31_RS09065	COG0700	Nucleoside recognition
C2U31_RS09070	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS09075	COG0242	peptide deformylase activity
C2U31_RS09095	COG0204	Acyl-transferase
C2U31_RS09100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2U31_RS09105	COG0751	glycine-tRNA ligase activity
C2U31_RS09110	COG0752	glycyl-tRNA synthetase alpha subunit
C2U31_RS09115	COG1024	Enoyl-CoA hydratase
C2U31_RS09130	COG2030	dehydratase
C2U31_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS09140	COG0583	DNA-binding transcription factor activity
C2U31_RS09155	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_RS09160	COG0183	Belongs to the thiolase family
C2U31_RS09170	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS09180	COG1024	Enoyl-CoA hydratase
C2U31_RS09190	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C2U31_RS09195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_RS09205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U31_RS09215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2U31_RS09225	COG0617	tRNA 3'-terminal CCA addition
C2U31_RS09240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2U31_RS09245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2U31_RS09250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U31_RS09255	COG0586	Pfam SNARE associated Golgi protein
C2U31_RS09260	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2U31_RS09265	COG0802	atpase or kinase
C2U31_RS09270	COG0114	fumarate hydratase activity
C2U31_RS09280	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS09295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_RS09305	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS09310	COG0583	DNA-binding transcription factor activity
C2U31_RS09320	COG0579	oxidoreductase
C2U31_RS09325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2U31_RS09330	COG0259	pyridoxamine-phosphate oxidase activity
C2U31_RS09345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_RS09350	COG0577	efflux transmembrane transporter activity
C2U31_RS09350	COG1136	(ABC) transporter
C2U31_RS09355	COG1538	Outer membrane efflux protein
C2U31_RS09360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2U31_RS09405	COG0640	Transcriptional regulator
C2U31_RS09425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U31_RS09450	COG2197	response regulator
C2U31_RS09485	COG0653	protein targeting
C2U31_RS09490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_RS09505	COG0583	DNA-binding transcription factor activity
C2U31_RS09510	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_RS09520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U31_RS09530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2U31_RS09535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2U31_RS09555	COG0583	DNA-binding transcription factor activity
C2U31_RS09560	COG0463	Glycosyl transferase, family 2
C2U31_RS09560	COG1216	Glycosyl transferase, family 2
C2U31_RS09590	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_RS09610	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U31_RS09615	COG4638	Rieske (2fe-2S)
C2U31_RS09640	COG0747	negative chemotaxis
C2U31_RS09645	COG0601	transmembrane transport
C2U31_RS09650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS09655	COG0444	Belongs to the ABC transporter superfamily
C2U31_RS09660	COG4608	Belongs to the ABC transporter superfamily
C2U31_RS09680	COG0488	(ABC) transporter
C2U31_RS09700	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C2U31_RS09705	COG2894	cell division
C2U31_RS09710	COG0850	regulation of cytokinetic process
C2U31_RS09715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2U31_RS09720	COG1271	oxidase subunit
C2U31_RS09725	COG1294	oxidase, subunit
C2U31_RS09730	COG0514	ATP-dependent DNA helicase (RecQ)
C2U31_RS09750	COG2255	four-way junction helicase activity
C2U31_RS09765	COG0632	four-way junction helicase activity
C2U31_RS09770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2U31_RS09790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U31_RS09800	COG0006	proline dipeptidase activity
C2U31_RS09815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2U31_RS09835	COG4783	chaperone-mediated protein folding
C2U31_RS09870	COG0513	Belongs to the DEAD box helicase family
C2U31_RS09885	COG1058	Belongs to the CinA family
C2U31_RS09885	COG1546	Belongs to the CinA family
C2U31_RS09890	COG1414	Transcriptional regulator
C2U31_RS09905	COG0167	dihydroorotate dehydrogenase activity
C2U31_RS09910	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C2U31_RS09915	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C2U31_RS09925	COG0583	DNA-binding transcription factor activity
C2U31_RS09960	COG3128	pkhd-type hydroxylase
C2U31_RS09965	COG4774	siderophore transport
C2U31_RS09975	COG2721	sulfolactate sulfo-lyase activity
C2U31_RS09980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS09990	COG4597	amino acid ABC transporter
C2U31_RS09995	COG0765	amino acid transport
C2U31_RS10000	COG1802	Transcriptional regulator
C2U31_RS10050	COG0629	single-stranded DNA binding
C2U31_RS10060	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2U31_RS10110	COG0740	serine-type endopeptidase activity
C2U31_RS10200	COG1280	lysine exporter protein (LysE YggA)
C2U31_RS10295	COG2003	Belongs to the UPF0758 family
C2U31_RS10300	COG0477	Major facilitator Superfamily
C2U31_RS10380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2U31_RS10385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2U31_RS10390	COG3135	benzoate transporter
C2U31_RS10395	COG2271	Major facilitator Superfamily
C2U31_RS10420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U31_RS10425	COG0183	Belongs to the thiolase family
C2U31_RS10430	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U31_RS10440	COG2814	Major facilitator Superfamily
C2U31_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS10470	COG3485	protocatechuate 3,4-dioxygenase
C2U31_RS10490	COG0583	DNA-binding transcription factor activity
C2U31_RS10495	COG2814	Major facilitator Superfamily
C2U31_RS10500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_RS10505	COG0657	acetylesterase activity
C2U31_RS10510	COG0702	epimerase
C2U31_RS10515	COG1733	regulation of RNA biosynthetic process
C2U31_RS10520	COG2814	Major facilitator Superfamily
C2U31_RS10525	COG2084	Dehydrogenase
C2U31_RS10530	COG1309	transcriptional regulator
C2U31_RS10560	COG3479	Phenolic acid decarboxylase
C2U31_RS10565	COG0583	DNA-binding transcription factor activity
C2U31_RS10570	COG0604	alcohol dehydrogenase
C2U31_RS10580	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2U31_RS10585	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS10595	COG2814	Major facilitator Superfamily
C2U31_RS10605	COG0583	DNA-binding transcription factor activity
C2U31_RS10620	COG0582	viral genome integration into host DNA
C2U31_RS10630	COG3038	cytochrome b561
C2U31_RS10645	COG1459	type II secretion system
C2U31_RS10650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2U31_RS10675	COG1450	Type ii and iii secretion system protein
C2U31_RS10680	COG2165	general secretion pathway protein
C2U31_RS10695	COG0745	RESPONSE REGULATOR receiver
C2U31_RS10700	COG5002	protein histidine kinase activity
C2U31_RS10710	COG2814	Major facilitator Superfamily
C2U31_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS10745	COG0247	lactate metabolic process
C2U31_RS10755	COG0657	acetylesterase activity
C2U31_RS10760	COG2207	Transcriptional regulator
C2U31_RS10780	COG1192	Involved in chromosome partitioning
C2U31_RS10840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2U31_RS11090	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2U31_RS11095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U31_RS11100	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U31_RS11105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U31_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS11135	COG0842	Transport permease protein
C2U31_RS11140	COG1129	ABC transporter
C2U31_RS11140	COG0842	Transport permease protein
C2U31_RS11165	COG0583	DNA-binding transcription factor activity
C2U31_RS11180	COG0582	viral genome integration into host DNA
C2U31_RS11200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U31_RS11205	COG0735	belongs to the Fur family
C2U31_RS11210	COG0497	DNA recombination
C2U31_RS11220	COG1420	regulation of RNA biosynthetic process
C2U31_RS11225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2U31_RS11235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2U31_RS11245	COG0443	Heat shock 70 kDa protein
C2U31_RS11250	COG0484	heat shock protein binding
C2U31_RS11260	COG0612	Peptidase, M16
C2U31_RS11285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U31_RS11320	COG0840	transmembrane signaling receptor activity
C2U31_RS11325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_RS11340	COG0745	RESPONSE REGULATOR receiver
C2U31_RS11345	COG2205	protein histidine kinase activity
C2U31_RS11350	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C2U31_RS11355	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C2U31_RS11360	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C2U31_RS11375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U31_RS11385	COG1193	negative regulation of DNA recombination
C2U31_RS11390	COG0492	ferredoxin-NADP+ reductase activity
C2U31_RS11395	COG1674	ftsk spoiiie
C2U31_RS11400	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2U31_RS11405	COG0251	oxidation-reduction process
C2U31_RS11410	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2U31_RS11415	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2U31_RS11415	COG0517	IMP dehydrogenase activity
C2U31_RS11435	COG0601	transmembrane transport
C2U31_RS11450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U31_RS11460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2U31_RS11470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2U31_RS11490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2U31_RS11530	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2U31_RS11535	COG0840	transmembrane signaling receptor activity
C2U31_RS11540	COG2205	protein histidine kinase activity
C2U31_RS11570	COG2274	protein secretion by the type I secretion system
C2U31_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS11590	COG3022	response to hydroperoxide
C2U31_RS11595	COG1289	transmembrane transporter activity
C2U31_RS11600	COG0028	Belongs to the TPP enzyme family
C2U31_RS11605	COG0440	acetolactate synthase activity
C2U31_RS11610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2U31_RS11615	COG1183	phosphatidylcholine synthase activity
C2U31_RS11625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2U31_RS11630	COG1185	polyribonucleotide nucleotidyltransferase activity
C2U31_RS11645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_RS11675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U31_RS11690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U31_RS11705	COG3121	Chaperone
C2U31_RS11735	COG2197	response regulator
C2U31_RS11740	COG4251	negative regulation of phosphorylation
C2U31_RS11740	COG2203	Gaf domain
C2U31_RS11740	COG5001	Diguanylate cyclase
C2U31_RS11740	COG3706	GGDEF domain
C2U31_RS11755	COG0583	DNA-binding transcription factor activity
C2U31_RS11760	COG0583	DNA-binding transcription factor activity
C2U31_RS11765	COG0745	RESPONSE REGULATOR receiver
C2U31_RS11790	COG0149	triose-phosphate isomerase activity
C2U31_RS11795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2U31_RS11840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U31_RS11880	COG0662	Cupin 2, conserved barrel domain protein
C2U31_RS11890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U31_RS11890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U31_RS11900	COG0583	DNA-binding transcription factor activity
C2U31_RS11905	COG2203	Gaf domain
C2U31_RS11905	COG2199	diguanylate cyclase activity
C2U31_RS11955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U31_RS11955	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C2U31_RS11980	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C2U31_RS11985	COG0789	Transcriptional regulator
C2U31_RS11990	COG0583	DNA-binding transcription factor activity
C2U31_RS11995	COG3048	D-serine ammonia-lyase activity
C2U31_RS12000	COG2271	Major facilitator Superfamily
C2U31_RS12030	COG3328	transposase activity
C2U31_RS12045	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS12065	COG2957	Belongs to the agmatine deiminase family
C2U31_RS12095	COG0477	Major facilitator Superfamily
C2U31_RS12105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U31_RS12115	COG0642	Histidine kinase
C2U31_RS12125	COG2851	Citrate transporter
C2U31_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS12170	COG3604	Transcriptional regulator
C2U31_RS12175	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C2U31_RS12185	COG3246	L-lysine catabolic process to acetate
C2U31_RS12190	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_RS12195	COG2814	Major facilitator Superfamily
C2U31_RS12210	COG4804	nuclease activity
C2U31_RS12225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_RS12240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U31_RS12250	COG3135	benzoate transporter
C2U31_RS12255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U31_RS12260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U31_RS12270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_RS12275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_RS12295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_RS12300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_RS12305	COG1309	transcriptional regulator
C2U31_RS12310	COG0583	DNA-binding transcription factor activity
C2U31_RS12320	COG0405	Gamma-glutamyltransferase
C2U31_RS12330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2U31_RS12355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_RS12360	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U31_RS12365	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U31_RS12370	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U31_RS12380	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C2U31_RS12390	COG1034	ATP synthesis coupled electron transport
C2U31_RS12395	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C2U31_RS12400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2U31_RS12410	COG0713	ATP synthesis coupled electron transport
C2U31_RS12425	COG1007	ATP synthesis coupled electron transport
C2U31_RS12435	COG4774	siderophore transport
C2U31_RS12440	COG0560	Phosphoserine phosphatase
C2U31_RS12445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2U31_RS12450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2U31_RS12455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2U31_RS12465	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U31_RS12470	COG0450	alkyl hydroperoxide reductase
C2U31_RS12485	COG1214	PFAM Peptidase M22, glycoprotease
C2U31_RS12490	COG1573	uracil-dna glycosylase
C2U31_RS12495	COG0477	Major facilitator Superfamily
C2U31_RS12500	COG1196	nuclear chromosome segregation
C2U31_RS12510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2U31_RS12515	COG1414	Transcriptional regulator
C2U31_RS12535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2U31_RS12540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_RS12550	COG2917	probably involved in intracellular septation
C2U31_RS12555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U31_RS12560	COG1122	ATPase activity
C2U31_RS12565	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2U31_RS12570	COG1268	BioY protein
C2U31_RS12605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2U31_RS12635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2U31_RS12640	COG2878	Part of a membrane complex involved in electron transport
C2U31_RS12665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C2U31_RS12675	COG0251	oxidation-reduction process
C2U31_RS12685	COG3228	Belongs to the MtfA family
C2U31_RS12690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U31_RS12700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U31_RS12710	COG0159	tryptophan synthase activity
C2U31_RS12715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2U31_RS12725	COG4804	nuclease activity
C2U31_RS12740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2U31_RS12750	COG3077	Addiction module antitoxin, RelB DinJ family
C2U31_RS12775	COG5489	Protein of unknown function (DUF736)
C2U31_RS12810	COG1192	Involved in chromosome partitioning
C2U31_RS12885	COG0583	DNA-binding transcription factor activity
C2U31_RS12905	COG4962	Type ii secretion system protein e
C2U31_RS12910	COG3838	Conjugal transfer protein Trbc
C2U31_RS12920	COG3451	type IV secretory pathway VirB4
C2U31_RS12960	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U31_RS12970	COG1530	ribonuclease E activity
C2U31_RS12980	COG0546	phosphoglycolate phosphatase activity
C2U31_RS12985	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U31_RS12990	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
C2U31_RS12995	COG3023	N-Acetylmuramoyl-L-alanine amidase
C2U31_RS13005	COG0424	maF-like protein
C2U31_RS13015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C2U31_RS13020	COG0416	fatty acid biosynthetic process
C2U31_RS13025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2U31_RS13030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2U31_RS13040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2U31_RS13045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2U31_RS13070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U31_RS13080	COG0681	Belongs to the peptidase S26 family
C2U31_RS13085	COG0571	ribonuclease III activity
C2U31_RS13090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2U31_RS13095	COG1381	Involved in DNA repair and RecF pathway recombination
C2U31_RS13100	COG0583	DNA-binding transcription factor activity
C2U31_RS13135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2U31_RS13160	COG0583	DNA-binding transcription factor activity
C2U31_RS13170	COG0791	NLP P60 protein
C2U31_RS13180	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C2U31_RS13190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U31_RS13195	COG0697	spore germination
C2U31_RS13200	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C2U31_RS13250	COG2153	protein acetylation
C2U31_RS13260	COG1446	asparaginase
C2U31_RS13265	COG4172	Belongs to the ABC transporter superfamily
C2U31_RS13270	COG0747	negative chemotaxis
C2U31_RS13305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_RS13315	COG0504	CTP synthase activity
C2U31_RS13325	COG0148	phosphopyruvate hydratase activity
C2U31_RS13340	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2U31_RS13350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2U31_RS13385	COG1981	membrane
C2U31_RS13405	COG0039	L-malate dehydrogenase activity
C2U31_RS13410	COG2188	Transcriptional regulator
C2U31_RS13415	COG2009	succinate dehydrogenase
C2U31_RS13420	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C2U31_RS13425	COG1053	succinate dehydrogenase
C2U31_RS13430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2U31_RS13435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C2U31_RS13440	COG0372	Belongs to the citrate synthase family
C2U31_RS13470	COG1129	ABC transporter
C2U31_RS13485	COG0642	Histidine kinase
C2U31_RS13510	COG0280	phosphate acetyltransferase
C2U31_RS13510	COG0281	malic enzyme
C2U31_RS13520	COG1297	OPT oligopeptide transporter protein
C2U31_RS13530	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C2U31_RS13535	COG1522	sequence-specific DNA binding
C2U31_RS13540	COG0567	Dehydrogenase, E1 component
C2U31_RS13545	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U31_RS13550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U31_RS13555	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C2U31_RS13580	COG0372	Belongs to the citrate synthase family
C2U31_RS13605	COG2183	response to ionizing radiation
C2U31_RS13610	COG1199	ATP-dependent helicase activity
C2U31_RS13620	COG0564	pseudouridine synthase activity
C2U31_RS13625	COG1496	oxidoreductase activity
C2U31_RS13630	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2U31_RS13635	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS13640	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
C2U31_RS13655	COG0672	)-iron permease
C2U31_RS13680	COG3237	CsbD-like
C2U31_RS13690	COG0189	ligase activity
C2U31_RS13690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2U31_RS13695	COG1132	(ABC) transporter
C2U31_RS13710	COG2833	Protein of unknown function (DUF455)
C2U31_RS13715	COG2951	lytic endotransglycosylase activity
C2U31_RS13730	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS13750	COG1696	Membrane protein involved in D-alanine export
C2U31_RS13770	COG1215	transferase activity, transferring glycosyl groups
C2U31_RS13780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2U31_RS13790	COG0582	viral genome integration into host DNA
C2U31_RS13915	COG0305	Participates in initiation and elongation during chromosome replication
C2U31_RS14035	COG4386	tail sheath protein
C2U31_RS14075	COG3299	homolog of phage Mu protein gp47
C2U31_RS14150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2U31_RS14165	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2U31_RS14175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2U31_RS14180	COG0287	Prephenate dehydrogenase
C2U31_RS14185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2U31_RS14190	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2U31_RS14210	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C2U31_RS14215	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C2U31_RS14220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U31_RS14225	COG1555	photosystem II stabilization
C2U31_RS14225	COG1596	polysaccharide export
C2U31_RS14240	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2U31_RS14255	COG0450	alkyl hydroperoxide reductase
C2U31_RS14270	COG4208	sulfate ABC transporter
C2U31_RS14280	COG0175	sulfate reduction
C2U31_RS14290	COG2895	sulfate adenylyltransferase (ATP) activity
C2U31_RS14310	COG0335	large ribosomal subunit rRNA binding
C2U31_RS14315	COG0494	nUDIX hydrolase
C2U31_RS14320	COG1162	GTPase activity
C2U31_RS14325	COG0501	Belongs to the peptidase M48B family
C2U31_RS14330	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C2U31_RS14335	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C2U31_RS14340	COG3327	negative regulation of DNA-templated transcription, initiation
C2U31_RS14345	COG3396	Phenylacetate-CoA oxygenase
C2U31_RS14350	COG3460	Phenylacetate-CoA oxygenase
C2U31_RS14355	COG3396	Phenylacetate-CoA oxygenase
C2U31_RS14360	COG2151	metal-sulfur cluster biosynthetic enzyme
C2U31_RS14365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U31_RS14370	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_RS14375	COG1024	Enoyl-CoA hydratase
C2U31_RS14380	COG2050	protein possibly involved in aromatic compounds catabolism
C2U31_RS14405	COG3483	tryptophan 2,3-dioxygenase activity
C2U31_RS14410	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_RS14415	COG2003	Belongs to the UPF0758 family
C2U31_RS14425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2U31_RS14430	COG0625	glutathione transferase activity
C2U31_RS14435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U31_RS14440	COG0642	Histidine kinase
C2U31_RS14460	COG0523	cobalamin synthesis protein
C2U31_RS14465	COG0583	DNA-binding transcription factor activity
C2U31_RS14475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2U31_RS14480	COG1187	pseudouridine synthase activity
C2U31_RS14485	COG0779	Required for maturation of 30S ribosomal subunits
C2U31_RS14490	COG0195	Participates in both transcription termination and antitermination
C2U31_RS14490	COG2251	uridine kinase activity
C2U31_RS14495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2U31_RS14500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2U31_RS14505	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2U31_RS14510	COG1217	gtp-binding protein TYPA
C2U31_RS14520	COG0583	DNA-binding transcription factor activity
C2U31_RS14530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U31_RS14530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2U31_RS14535	COG0428	transporter
C2U31_RS14540	COG0412	Dienelactone hydrolase
C2U31_RS14545	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2U31_RS14550	COG1760	l-serine dehydratase
C2U31_RS14560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U31_RS14565	COG2706	6-phosphogluconolactonase activity
C2U31_RS14570	COG4214	carbohydrate transport
C2U31_RS14575	COG1129	ABC transporter
C2U31_RS14580	COG4213	ABC transporter substrate-binding protein
C2U31_RS14590	COG0501	Belongs to the peptidase M48B family
C2U31_RS14615	COG3842	ATPase activity
C2U31_RS14625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U31_RS14630	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U31_RS14650	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS14660	COG1722	exodeoxyribonuclease VII activity
C2U31_RS14665	COG0142	geranyltranstransferase activity
C2U31_RS14675	COG1469	GTP cyclohydrolase I activity
C2U31_RS14680	COG3739	integral membrane protein
C2U31_RS14685	COG0360	Binds together with S18 to 16S ribosomal RNA
C2U31_RS14690	COG2965	DNA replication, synthesis of RNA primer
C2U31_RS14695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2U31_RS14700	COG0359	binds to the 23S rRNA
C2U31_RS14710	COG0305	Participates in initiation and elongation during chromosome replication
C2U31_RS14720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U31_RS14755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS14810	COG0540	Belongs to the ATCase OTCase family
C2U31_RS14830	COG0477	Major facilitator Superfamily
C2U31_RS14845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2U31_RS14850	COG2137	regulation of response to DNA damage stimulus
C2U31_RS14865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U31_RS14875	COG0045	succinate-CoA ligase (ADP-forming) activity
C2U31_RS14880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2U31_RS14885	COG0861	Integral membrane protein TerC family
C2U31_RS14890	COG0861	Integral membrane protein TerC family
C2U31_RS14895	COG0181	hydroxymethylbilane synthase activity
C2U31_RS14915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C2U31_RS14925	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS14975	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2U31_RS14980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U31_RS14990	COG0436	Aminotransferase
C2U31_RS15010	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C2U31_RS15015	COG0308	aminopeptidase N
C2U31_RS15030	COG0312	modulator of DNA gyrase
C2U31_RS15035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U31_RS15040	COG0277	FAD linked oxidase domain protein
C2U31_RS15045	COG0277	FAD linked oxidase domain protein
C2U31_RS15050	COG0277	FAD linked oxidase domain protein
C2U31_RS15055	COG0247	lactate metabolic process
C2U31_RS15085	COG0583	DNA-binding transcription factor activity
C2U31_RS15090	COG0482	sulfurtransferase activity
C2U31_RS15095	COG0730	response to heat
C2U31_RS15100	COG0625	glutathione transferase activity
C2U31_RS15110	COG3909	cytochrome
C2U31_RS15285	COG0697	spore germination
C2U31_RS15325	COG0069	glutamate synthase activity
C2U31_RS15330	COG2391	methyltransferase activity
C2U31_RS15340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2U31_RS15350	COG0697	spore germination
C2U31_RS15360	COG0583	DNA-binding transcription factor activity
C2U31_RS15365	COG0477	Major facilitator Superfamily
C2U31_RS15385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2U31_RS15395	COG1760	l-serine dehydratase
C2U31_RS15410	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U31_RS15410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2U31_RS15445	COG0557	exoribonuclease II activity
C2U31_RS15450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U31_RS15455	COG0626	cystathionine gamma-synthase activity
C2U31_RS15460	COG3128	pkhd-type hydroxylase
C2U31_RS15465	COG0776	regulation of translation
C2U31_RS15495	COG0642	Histidine kinase
C2U31_RS15500	COG3158	transport of potassium into the cell
C2U31_RS15505	COG0137	argininosuccinate synthase activity
C2U31_RS15535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2U31_RS15540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U31_RS15555	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C2U31_RS15555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C2U31_RS15565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2U31_RS15570	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C2U31_RS15580	COG2376	Dihydroxyacetone kinase
C2U31_RS15595	COG3842	ATPase activity
C2U31_RS15600	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U31_RS15605	COG1177	transmembrane transport
C2U31_RS15615	COG2094	Belongs to the DNA glycosylase MPG family
C2U31_RS15635	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS15640	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C2U31_RS15655	COG0704	Plays a role in the regulation of phosphate uptake
C2U31_RS15720	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C2U31_RS15725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2U31_RS15725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2U31_RS15730	COG1643	Atp-dependent helicase
C2U31_RS15740	COG1116	anion transmembrane transporter activity
C2U31_RS15755	COG0438	transferase activity, transferring glycosyl groups
C2U31_RS15760	COG0726	polysaccharide deacetylase
C2U31_RS15765	COG0463	Glycosyl transferase, family 2
C2U31_RS15775	COG0726	polysaccharide deacetylase
C2U31_RS15785	COG0124	histidyl-tRNA synthetase
C2U31_RS15805	COG1132	(ABC) transporter
C2U31_RS15810	COG0475	glutathione-regulated potassium exporter activity
C2U31_RS15810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2U31_RS15825	COG2203	Gaf domain
C2U31_RS15825	COG3706	GGDEF domain
C2U31_RS15825	COG4251	negative regulation of phosphorylation
C2U31_RS15825	COG5001	Diguanylate cyclase
C2U31_RS15845	COG1530	ribonuclease E activity
C2U31_RS15890	COG0583	DNA-binding transcription factor activity
C2U31_RS15905	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_RS15915	COG0477	Major facilitator Superfamily
C2U31_RS15925	COG0154	amidase activity
C2U31_RS15945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2U31_RS15960	COG0495	leucyl-tRNA aminoacylation
C2U31_RS15965	COG2814	Major facilitator Superfamily
C2U31_RS15980	COG1686	Belongs to the peptidase S11 family
C2U31_RS16015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2U31_RS16020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2U31_RS16025	COG2814	Major facilitator Superfamily
C2U31_RS16045	COG4176	ABC-type proline glycine betaine transport system permease component
C2U31_RS16050	COG3448	diguanylate cyclase activity
C2U31_RS16050	COG4175	Glycine betaine
C2U31_RS16060	COG0183	Belongs to the thiolase family
C2U31_RS16070	COG1802	Transcriptional regulator
C2U31_RS16080	COG1024	Enoyl-CoA hydratase
C2U31_RS16085	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_RS16095	COG1595	DNA-templated transcription, initiation
C2U31_RS16100	COG3712	iron ion homeostasis
C2U31_RS16120	COG4120	Belongs to the binding-protein-dependent transport system permease family
C2U31_RS16125	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2U31_RS16135	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2U31_RS16155	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2U31_RS16160	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2U31_RS16165	COG4149	molybdate abc transporter
C2U31_RS16170	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C2U31_RS16195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_RS16200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_RS16210	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C2U31_RS16215	COG0736	holo-[acyl-carrier-protein] synthase activity
C2U31_RS16230	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2U31_RS16240	COG1858	cytochrome C peroxidase
C2U31_RS16245	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U31_RS16245	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2U31_RS16250	COG2224	Isocitrate lyase
C2U31_RS16255	COG1802	Transcriptional regulator
C2U31_RS16260	COG1879	ABC-type sugar transport system periplasmic component
C2U31_RS16265	COG1129	ABC transporter
C2U31_RS16270	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U31_RS16275	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_RS16280	COG3246	L-lysine catabolic process to acetate
C2U31_RS16285	COG3386	PFAM SMP-30 Gluconolaconase
C2U31_RS16290	COG4106	trans-aconitate 2-methyltransferase activity
C2U31_RS16290	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C2U31_RS16300	COG0156	8-amino-7-oxononanoate synthase activity
C2U31_RS16305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2U31_RS16320	COG3278	Belongs to the heme-copper respiratory oxidase family
C2U31_RS16340	COG0348	domain, Protein
C2U31_RS16370	COG4948	Mandelate Racemase Muconate Lactonizing
C2U31_RS16380	COG1131	(ABC) transporter
C2U31_RS16385	COG0842	Transport permease protein
C2U31_RS16415	COG1272	protein, Hemolysin III
C2U31_RS16445	COG2169	Transcriptional regulator
C2U31_RS16475	COG1024	Enoyl-CoA hydratase
C2U31_RS16480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_RS16485	COG0154	amidase activity
C2U31_RS16490	COG2186	Transcriptional regulator
C2U31_RS16510	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_RS16525	COG2207	Transcriptional regulator
C2U31_RS16525	COG3708	Transcriptional regulator
C2U31_RS16530	COG2814	Major facilitator Superfamily
C2U31_RS16540	COG1464	Belongs to the NlpA lipoprotein family
C2U31_RS16545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2U31_RS16550	COG2011	ABC-type metal ion transport system permease component
C2U31_RS16595	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS16620	COG0443	Heat shock 70 kDa protein
C2U31_RS16625	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
C2U31_RS16635	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2U31_RS16665	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS16670	COG1473	amidohydrolase
C2U31_RS16700	COG2951	lytic endotransglycosylase activity
C2U31_RS16705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C2U31_RS16720	COG0456	acetyltransferase
C2U31_RS16730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS16735	COG0601	transmembrane transport
C2U31_RS16740	COG4166	transmembrane transport
C2U31_RS16755	COG0488	(ABC) transporter
C2U31_RS16765	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2U31_RS16795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U31_RS16800	COG1595	DNA-templated transcription, initiation
C2U31_RS16815	COG3530	Putative quorum-sensing-regulated virulence factor
C2U31_RS16820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2U31_RS16825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2U31_RS16840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U31_RS16845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U31_RS16850	COG0004	ammonium transporteR
C2U31_RS16855	COG0347	Belongs to the P(II) protein family
C2U31_RS16865	COG2960	long-chain fatty acid transporting porin activity
C2U31_RS16875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2U31_RS16880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2U31_RS16885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2U31_RS16890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2U31_RS16890	COG0072	phenylalanine-tRNA ligase activity
C2U31_RS16915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U31_RS16925	COG2072	flavoprotein involved in K transport
C2U31_RS16935	COG0384	phenazine biosynthesis protein PhzF
C2U31_RS16950	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS16970	COG1522	sequence-specific DNA binding
C2U31_RS17005	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS17020	COG2358	TRAP transporter, solute receptor (TAXI family
C2U31_RS17045	COG0583	DNA-binding transcription factor activity
C2U31_RS17060	COG5265	(ABC) transporter
C2U31_RS17065	COG0656	L-ascorbic acid biosynthetic process
C2U31_RS17080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2U31_RS17090	COG2207	Transcriptional regulator
C2U31_RS17095	COG2223	nitrite transmembrane transporter activity
C2U31_RS17105	COG1215	transferase activity, transferring glycosyl groups
C2U31_RS17110	COG1649	PFAM Uncharacterised BCR, COG1649
C2U31_RS17110	COG0726	polysaccharide deacetylase
C2U31_RS17115	COG0457	Tetratricopeptide repeat
C2U31_RS17120	COG2199	diguanylate cyclase activity
C2U31_RS17145	COG1610	YqeY-like protein
C2U31_RS17150	COG0583	DNA-binding transcription factor activity
C2U31_RS17155	COG1942	4-Oxalocrotonate Tautomerase
C2U31_RS17165	COG1959	2 iron, 2 sulfur cluster binding
C2U31_RS17170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_RS17180	COG0506	proline dehydrogenase activity
C2U31_RS17200	COG0583	DNA-binding transcription factor activity
C2U31_RS17210	COG0625	glutathione transferase activity
C2U31_RS17225	COG2814	Major facilitator Superfamily
C2U31_RS17230	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS17235	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_RS17250	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U31_RS17255	COG1280	lysine exporter protein (LysE YggA)
C2U31_RS17270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U31_RS17275	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2U31_RS17280	COG0515	serine threonine protein kinase
C2U31_RS17280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2U31_RS17295	COG1280	lysine exporter protein (LysE YggA)
C2U31_RS17300	COG0406	alpha-ribazole phosphatase activity
C2U31_RS17320	COG0697	spore germination
C2U31_RS17325	COG0697	spore germination
C2U31_RS17340	COG0534	Mate efflux family protein
C2U31_RS17345	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C2U31_RS17355	COG2226	methyltransferase
C2U31_RS17360	COG1609	Transcriptional regulator
C2U31_RS17365	COG2271	Major facilitator Superfamily
C2U31_RS17370	COG0154	amidase activity
C2U31_RS17380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U31_RS17425	COG0307	riboflavin synthase, alpha
C2U31_RS17435	COG2271	Major facilitator Superfamily
C2U31_RS17445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2U31_RS17450	COG4650	regulator
C2U31_RS17460	COG1690	Belongs to the RtcB family
C2U31_RS17465	COG3541	Predicted nucleotidyltransferase
C2U31_RS17480	COG0789	Transcriptional regulator
C2U31_RS17500	COG3842	ATPase activity
C2U31_RS17505	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U31_RS17515	COG0726	polysaccharide deacetylase
C2U31_RS17520	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS17525	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS17530	COG0154	amidase activity
C2U31_RS17540	COG0022	dehydrogenase e1 component
C2U31_RS17560	COG2814	Major facilitator Superfamily
C2U31_RS17570	COG2814	Major facilitator Superfamily
C2U31_RS17575	COG0165	Argininosuccinate lyase
C2U31_RS17580	COG0668	transmembrane transport
C2U31_RS17620	COG2233	PERMEase
C2U31_RS17625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U31_RS17650	COG0469	pyruvate kinase activity
C2U31_RS17660	COG2084	Dehydrogenase
C2U31_RS17665	COG3622	Belongs to the hyi family
C2U31_RS17670	COG3960	tartronate-semialdehyde synthase activity
C2U31_RS17675	COG0583	DNA-binding transcription factor activity
C2U31_RS17680	COG0154	amidase activity
C2U31_RS17685	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS17725	COG2165	general secretion pathway protein
C2U31_RS17750	COG0583	DNA-binding transcription factor activity
C2U31_RS17765	COG0601	transmembrane transport
C2U31_RS17770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS17775	COG4172	Belongs to the ABC transporter superfamily
C2U31_RS17780	COG2207	Transcriptional regulator
C2U31_RS17790	COG1280	lysine exporter protein (LysE YggA)
C2U31_RS17795	COG4681	YaeQ
C2U31_RS17815	COG0477	Major facilitator Superfamily
C2U31_RS17820	COG3161	chorismate lyase activity
C2U31_RS17825	COG1187	pseudouridine synthase activity
C2U31_RS17855	COG1999	signal sequence binding
C2U31_RS17865	COG0339	signal peptide processing
C2U31_RS17870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2U31_RS17875	COG4566	intracellular signal transduction
C2U31_RS17890	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2U31_RS17895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2U31_RS17900	COG4804	nuclease activity
C2U31_RS17930	COG4797	methyltransferase
C2U31_RS17930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U31_RS17935	COG1191	sigma factor activity
C2U31_RS17960	COG0745	RESPONSE REGULATOR receiver
C2U31_RS17970	COG0835	chemotaxis
C2U31_RS17975	COG0840	transmembrane signaling receptor activity
C2U31_RS17980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2U31_RS17985	COG2201	protein-glutamate methylesterase activity
C2U31_RS17990	COG0745	RESPONSE REGULATOR receiver
C2U31_RS17995	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C2U31_RS18010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U31_RS18025	COG2747	anti-sigma28 factor FlgM
C2U31_RS18040	COG1558	bacterial-type flagellum-dependent cell motility
C2U31_RS18055	COG4787	bacterial-type flagellum-dependent cell motility
C2U31_RS18090	COG0840	transmembrane signaling receptor activity
C2U31_RS18095	COG0840	transmembrane signaling receptor activity
C2U31_RS18105	COG0840	transmembrane signaling receptor activity
C2U31_RS18130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U31_RS18160	COG1317	bacterial-type flagellum organization
C2U31_RS18165	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2U31_RS18170	COG1766	The M ring may be actively involved in energy transduction
C2U31_RS18175	COG1677	Flagellar hook-basal body complex protein FliE
C2U31_RS18185	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2U31_RS18205	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2U31_RS18225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_RS18230	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS18240	COG0285	dihydrofolate synthase activity
C2U31_RS18260	COG1451	nucleotide metabolic process
C2U31_RS18270	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U31_RS18280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C2U31_RS18285	COG0024	Methionine aminopeptidase
C2U31_RS18290	COG0052	Belongs to the universal ribosomal protein uS2 family
C2U31_RS18295	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2U31_RS18300	COG0528	UMP kinase activity
C2U31_RS18305	COG0233	cytoplasmic translational termination
C2U31_RS18310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2U31_RS18315	COG0575	Belongs to the CDS family
C2U31_RS18320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2U31_RS18325	COG0750	zinc metalloprotease
C2U31_RS18330	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U31_RS18335	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C2U31_RS18340	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U31_RS18345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2U31_RS18355	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U31_RS18360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2U31_RS18365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2U31_RS18385	COG0477	Major facilitator Superfamily
C2U31_RS18390	COG0583	DNA-binding transcription factor activity
C2U31_RS18395	COG1309	transcriptional regulator
C2U31_RS18405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_RS18410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2U31_RS18420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U31_RS18420	COG2169	Transcriptional regulator
C2U31_RS18425	COG0519	Catalyzes the synthesis of GMP from XMP
C2U31_RS18425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U31_RS18435	COG0330	HflC and HflK could
C2U31_RS18445	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2U31_RS18450	COG2867	negative regulation of translational initiation
C2U31_RS18455	COG2914	Belongs to the UPF0125 (RnfH) family
C2U31_RS18460	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS18465	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2U31_RS18485	COG0354	folic acid binding
C2U31_RS18490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2U31_RS18495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2U31_RS18500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2U31_RS18505	COG0084	hydrolase, TatD family'
C2U31_RS18520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS18525	COG0765	amino acid transport
C2U31_RS18530	COG1126	abc transporter atp-binding protein
C2U31_RS18535	COG0010	Belongs to the arginase family
C2U31_RS18545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2U31_RS18560	COG0095	Lipoate-protein ligase
C2U31_RS18575	COG0625	glutathione transferase activity
C2U31_RS18585	COG1522	sequence-specific DNA binding
C2U31_RS18590	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2U31_RS18600	COG0386	Belongs to the glutathione peroxidase family
C2U31_RS18605	COG2814	Major facilitator Superfamily
C2U31_RS18635	COG0840	transmembrane signaling receptor activity
C2U31_RS18640	COG0415	Belongs to the DNA photolyase family
C2U31_RS18645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_RS18675	COG3949	Membrane
C2U31_RS18740	COG1522	sequence-specific DNA binding
C2U31_RS18745	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C2U31_RS18765	COG0625	glutathione transferase activity
C2U31_RS18805	COG0513	Belongs to the DEAD box helicase family
C2U31_RS18815	COG4691	Plasmid stability protein
C2U31_RS18820	COG1414	Transcriptional regulator
C2U31_RS18840	COG1522	sequence-specific DNA binding
C2U31_RS18850	COG4166	transmembrane transport
C2U31_RS18855	COG0601	transmembrane transport
C2U31_RS18860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS18875	COG1228	amidohydrolase
C2U31_RS18895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS18900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS18905	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C2U31_RS18910	COG4521	taurine ABC transporter
C2U31_RS18930	COG1414	Transcriptional regulator
C2U31_RS18935	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U31_RS18940	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS18950	COG2721	sulfolactate sulfo-lyase activity
C2U31_RS18955	COG0765	amino acid transport
C2U31_RS18960	COG0765	amino acid transport
C2U31_RS18995	COG1966	Carbon starvation protein
C2U31_RS19000	COG2879	small protein
C2U31_RS19010	COG2837	iron assimilation
C2U31_RS19015	COG2814	Major facilitator Superfamily
C2U31_RS19025	COG1408	metallophosphoesterase
C2U31_RS19035	COG0688	phosphatidylethanolamine metabolic process
C2U31_RS19040	COG0488	(ABC) transporter
C2U31_RS19060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_RS19065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C2U31_RS19070	COG2203	Gaf domain
C2U31_RS19070	COG2200	EAL domain
C2U31_RS19070	COG2199	diguanylate cyclase activity
C2U31_RS19105	COG0783	Belongs to the Dps family
C2U31_RS19110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2U31_RS19125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2U31_RS19130	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C2U31_RS19135	COG0745	RESPONSE REGULATOR receiver
C2U31_RS19140	COG5002	protein histidine kinase activity
C2U31_RS19150	COG0574	Belongs to the PEP-utilizing enzyme family
C2U31_RS19150	COG3848	Pyruvate phosphate dikinase
C2U31_RS19160	COG2070	2-Nitropropane dioxygenase
C2U31_RS19200	COG0583	DNA-binding transcription factor activity
C2U31_RS19210	COG0747	negative chemotaxis
C2U31_RS19215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS19225	COG2188	Transcriptional regulator
C2U31_RS19255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2U31_RS19260	COG0066	3-isopropylmalate dehydratase activity
C2U31_RS19280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2U31_RS19290	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2U31_RS19295	COG0589	response to stress
C2U31_RS19315	COG2197	response regulator
C2U31_RS19330	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2U31_RS19330	COG0617	tRNA 3'-terminal CCA addition
C2U31_RS19330	COG0517	IMP dehydrogenase activity
C2U31_RS19335	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C2U31_RS19355	COG0583	DNA-binding transcription factor activity
C2U31_RS19360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U31_RS19375	COG2223	nitrite transmembrane transporter activity
C2U31_RS19380	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2U31_RS19385	COG1140	nitrate reductase beta subunit
C2U31_RS19390	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2U31_RS19395	COG2181	nitrate reductase activity
C2U31_RS19400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_RS19405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U31_RS19410	COG0288	reversible hydration of carbon dioxide
C2U31_RS19415	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2U31_RS19420	COG3850	Histidine kinase
C2U31_RS19425	COG2197	response regulator
C2U31_RS19430	COG0826	peptidase U32
C2U31_RS19435	COG0826	peptidase U32
C2U31_RS19440	COG3154	lipid carrier protein
C2U31_RS19445	COG4221	oxidoreductase activity
C2U31_RS19450	COG4597	amino acid ABC transporter
C2U31_RS19455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS19475	COG4977	sequence-specific DNA binding
C2U31_RS19490	COG1116	anion transmembrane transporter activity
C2U31_RS19495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U31_RS19500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS19510	COG4771	TonB-dependent receptor
C2U31_RS19560	COG4774	siderophore transport
C2U31_RS19565	COG3971	2-oxopent-4-enoate hydratase activity
C2U31_RS19575	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS19580	COG0346	lactoylglutathione lyase activity
C2U31_RS19605	COG0477	Major facilitator Superfamily
C2U31_RS19655	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C2U31_RS19680	COG2814	Major facilitator Superfamily
C2U31_RS19685	COG2897	thiosulfate sulfurtransferase activity
C2U31_RS19710	COG4566	intracellular signal transduction
C2U31_RS19715	COG2205	protein histidine kinase activity
C2U31_RS19715	COG4191	Histidine kinase
C2U31_RS19715	COG0745	RESPONSE REGULATOR receiver
C2U31_RS19730	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2U31_RS19775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_RS19790	COG0583	DNA-binding transcription factor activity
C2U31_RS19795	COG1509	lysine 2,3-aminomutase activity
C2U31_RS19810	COG0625	glutathione transferase activity
C2U31_RS19835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS19840	COG0765	amino acid transport
C2U31_RS19845	COG1126	abc transporter atp-binding protein
C2U31_RS19885	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_RS19890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_RS19895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2U31_RS19905	COG2814	Major facilitator Superfamily
C2U31_RS19940	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C2U31_RS19950	COG0390	transport system, permease component
C2U31_RS19955	COG0586	Pfam SNARE associated Golgi protein
C2U31_RS19960	COG0534	Mate efflux family protein
C2U31_RS19970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2U31_RS19985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2U31_RS19995	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U31_RS20010	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U31_RS20035	COG3971	2-oxopent-4-enoate hydratase activity
C2U31_RS20045	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C2U31_RS20050	COG0625	glutathione transferase activity
C2U31_RS20070	COG2124	cytochrome p450
C2U31_RS20085	COG2192	nodulation
C2U31_RS20095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U31_RS20100	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_RS20140	COG2207	Transcriptional regulator
C2U31_RS20150	COG2072	flavoprotein involved in K transport
C2U31_RS20155	COG0657	acetylesterase activity
C2U31_RS20160	COG1454	alcohol dehydrogenase
C2U31_RS20165	COG0698	ribose 5-phosphate isomerase
C2U31_RS20170	COG1937	Protein conserved in bacteria
C2U31_RS20185	COG0589	response to stress
C2U31_RS20190	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C2U31_RS20195	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U31_RS20205	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U31_RS20225	COG0071	Belongs to the small heat shock protein (HSP20) family
C2U31_RS20250	COG0148	phosphopyruvate hydratase activity
C2U31_RS20275	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS20280	COG2814	Major facilitator Superfamily
C2U31_RS20310	COG1024	Enoyl-CoA hydratase
C2U31_RS20315	COG0596	Alpha beta hydrolase
C2U31_RS20330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U31_RS20335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2U31_RS20350	COG3395	kinase activity
C2U31_RS20355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U31_RS20380	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2U31_RS20390	COG0789	Transcriptional regulator
C2U31_RS20400	COG1473	amidohydrolase
C2U31_RS20405	COG0583	DNA-binding transcription factor activity
C2U31_RS20420	COG2203	Gaf domain
C2U31_RS20420	COG2199	diguanylate cyclase activity
C2U31_RS20490	COG1459	type II secretion system
C2U31_RS20525	COG1846	Transcriptional regulator
C2U31_RS20530	COG2807	transmembrane transport
C2U31_RS20545	COG1024	Enoyl-CoA hydratase
C2U31_RS20555	COG2205	protein histidine kinase activity
C2U31_RS20560	COG1253	flavin adenine dinucleotide binding
C2U31_RS20575	COG2200	EAL domain
C2U31_RS20575	COG2199	diguanylate cyclase activity
C2U31_RS20580	COG1289	transmembrane transporter activity
C2U31_RS20590	COG1464	Belongs to the NlpA lipoprotein family
C2U31_RS20595	COG0010	Belongs to the arginase family
C2U31_RS20605	COG2363	Small membrane protein
C2U31_RS20610	COG0697	spore germination
C2U31_RS20620	COG2133	pyrroloquinoline quinone binding
C2U31_RS20625	COG0625	glutathione transferase activity
C2U31_RS20650	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_RS20660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2U31_RS20670	COG1653	transport
C2U31_RS20675	COG1175	transmembrane transport
C2U31_RS20680	COG0395	ABC-type sugar transport system, permease component
C2U31_RS20685	COG3842	ATPase activity
C2U31_RS20700	COG2205	protein histidine kinase activity
C2U31_RS20705	COG0745	RESPONSE REGULATOR receiver
C2U31_RS20720	COG0783	Belongs to the Dps family
C2U31_RS20730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2U31_RS20740	COG0583	DNA-binding transcription factor activity
C2U31_RS20765	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U31_RS20770	COG1178	ABC-type Fe3 transport system permease component
C2U31_RS20775	COG3842	ATPase activity
C2U31_RS20785	COG1690	Belongs to the RtcB family
C2U31_RS20790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C2U31_RS20795	COG1741	Belongs to the pirin family
C2U31_RS20800	COG1741	Belongs to the pirin family
C2U31_RS20805	COG0583	DNA-binding transcription factor activity
C2U31_RS20810	COG2204	response regulator
C2U31_RS20825	COG0174	glutamine synthetase
C2U31_RS20830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U31_RS20835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2U31_RS20845	COG0840	transmembrane signaling receptor activity
C2U31_RS20850	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS20860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2U31_RS20865	COG1561	YicC-like family, N-terminal region
C2U31_RS20890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS20900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_RS20905	COG1024	Enoyl-CoA hydratase
C2U31_RS20920	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_RS20925	COG0833	amino acid
C2U31_RS20930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2U31_RS20935	COG0791	NLP P60 protein
C2U31_RS20940	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS20945	COG2863	cytochrome
C2U31_RS20950	COG3258	Cytochrome c
C2U31_RS20955	COG0194	GDP metabolic process
C2U31_RS20960	COG1758	RNA polymerase activity
C2U31_RS20965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2U31_RS20970	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2U31_RS20990	COG2271	Major facilitator Superfamily
C2U31_RS20995	COG1126	abc transporter atp-binding protein
C2U31_RS21000	COG0765	amino acid transport
C2U31_RS21005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS21025	COG2816	NAD+ diphosphatase activity
C2U31_RS21045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_RS21055	COG0411	ABC transporter
C2U31_RS21060	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2U31_RS21075	COG4336	lyase activity
C2U31_RS21080	COG0583	DNA-binding transcription factor activity
C2U31_RS21110	COG0583	DNA-binding transcription factor activity
C2U31_RS21120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U31_RS21125	COG0560	Phosphoserine phosphatase
C2U31_RS21130	COG0583	DNA-binding transcription factor activity
C2U31_RS21135	COG3842	ATPase activity
C2U31_RS21140	COG1178	ABC-type Fe3 transport system permease component
C2U31_RS21150	COG4181	ATPase activity
C2U31_RS21160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_RS21170	COG0584	glycerophosphoryl diester phosphodiesterase
C2U31_RS21175	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C2U31_RS21185	COG5383	Protein conserved in bacteria
C2U31_RS21190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS21200	COG0678	peroxiredoxin activity
C2U31_RS21200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2U31_RS21210	COG2217	Heavy metal translocating P-type atpase
C2U31_RS21220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2U31_RS21255	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2U31_RS21260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2U31_RS21265	COG2252	PERMEase
C2U31_RS21270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_RS21275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_RS21310	COG0488	(ABC) transporter
C2U31_RS21315	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2U31_RS21335	COG1320	monovalent cation:proton antiporter activity
C2U31_RS21340	COG2212	antiporter activity
C2U31_RS21345	COG1863	multisubunit Na H antiporter MnhE subunit
C2U31_RS21350	COG0651	ATP synthesis coupled electron transport
C2U31_RS21355	COG1006	Multisubunit Na H antiporter MnhC subunit
C2U31_RS21360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2U31_RS21360	COG2111	Na H antiporter
C2U31_RS21390	COG0420	3'-5' exonuclease activity
C2U31_RS21395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_RS21425	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS21445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_RS21450	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_RS21475	COG0395	ABC-type sugar transport system, permease component
C2U31_RS21485	COG3842	ATPase activity
C2U31_RS21490	COG3842	ATPase activity
C2U31_RS21525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U31_RS21550	COG1902	pentaerythritol trinitrate reductase activity
C2U31_RS21565	COG0602	queuosine metabolic process
C2U31_RS21570	COG0720	synthase
C2U31_RS21580	COG1289	transmembrane transporter activity
C2U31_RS21590	COG1566	PFAM secretion protein HlyD family protein
C2U31_RS21615	COG0411	ABC transporter
C2U31_RS21625	COG0154	amidase activity
C2U31_RS21635	COG0251	oxidation-reduction process
C2U31_RS21645	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_RS21660	COG0400	carboxylic ester hydrolase activity
C2U31_RS21665	COG0833	amino acid
C2U31_RS21670	COG0159	tryptophan synthase activity
C2U31_RS21675	COG0133	tryptophan synthase activity
C2U31_RS21685	COG1247	-acetyltransferase
C2U31_RS21690	COG0586	Pfam SNARE associated Golgi protein
C2U31_RS21730	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS21735	COG0531	amino acid
C2U31_RS21740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U31_RS21770	COG0587	DNA-directed DNA polymerase activity
C2U31_RS21855	COG1414	Transcriptional regulator
C2U31_RS21870	COG0667	Aldo Keto reductase
C2U31_RS21875	COG1309	transcriptional regulator
C2U31_RS21895	COG1683	Conserved Protein
C2U31_RS21905	COG2207	Transcriptional regulator
C2U31_RS21925	COG1360	Flagellar Motor Protein
C2U31_RS21930	COG3795	YCII-related domain
C2U31_RS21940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_RS21945	COG3795	YCII-related domain
C2U31_RS21955	COG4941	Belongs to the sigma-70 factor family
C2U31_RS21960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U31_RS21960	COG2169	Transcriptional regulator
C2U31_RS21965	COG0697	spore germination
C2U31_RS22000	COG0456	acetyltransferase
C2U31_RS22010	COG1846	Transcriptional regulator
C2U31_RS22070	COG0625	glutathione transferase activity
C2U31_RS22075	COG2733	membrane
C2U31_RS22085	COG0765	amino acid transport
C2U31_RS22090	COG0765	amino acid transport
C2U31_RS22130	COG0583	DNA-binding transcription factor activity
C2U31_RS22140	COG0183	Belongs to the thiolase family
C2U31_RS22145	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS22150	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS22155	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_RS22165	COG1464	Belongs to the NlpA lipoprotein family
C2U31_RS22225	COG1522	sequence-specific DNA binding
C2U31_RS22230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_RS22235	COG3842	ATPase activity
C2U31_RS22240	COG1840	ABC-type Fe3 transport system, periplasmic component
C2U31_RS22245	COG4149	molybdate abc transporter
C2U31_RS22250	COG5001	Diguanylate cyclase
C2U31_RS22250	COG3706	GGDEF domain
C2U31_RS22250	COG2203	Gaf domain
C2U31_RS22250	COG4251	negative regulation of phosphorylation
C2U31_RS22255	COG2201	protein-glutamate methylesterase activity
C2U31_RS22285	COG0154	amidase activity
C2U31_RS22290	COG0583	DNA-binding transcription factor activity
C2U31_RS22325	COG0183	Belongs to the thiolase family
C2U31_RS22330	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS22340	COG2030	dehydratase
C2U31_RS22345	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS22355	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS22380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_RS22385	COG1024	Enoyl-CoA hydratase
C2U31_RS22395	COG0456	acetyltransferase
C2U31_RS22410	COG0583	DNA-binding transcription factor activity
C2U31_RS22420	COG0183	Belongs to the thiolase family
C2U31_RS22425	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_RS22430	COG0477	Major facilitator Superfamily
C2U31_RS22445	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2U31_RS22460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS22500	COG0251	oxidation-reduction process
C2U31_RS22535	COG1280	lysine exporter protein (LysE YggA)
C2U31_RS22550	COG2169	Transcriptional regulator
C2U31_RS22550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2U31_RS22580	COG2084	Dehydrogenase
C2U31_RS22585	COG1309	transcriptional regulator
C2U31_RS22610	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS22630	COG3719	Belongs to the RNase T2 family
C2U31_RS22640	COG4221	oxidoreductase activity
C2U31_RS22660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C2U31_RS22665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2U31_RS22670	COG1802	Transcriptional regulator
C2U31_RS22725	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2U31_RS22735	COG0640	Transcriptional regulator
C2U31_RS22760	COG3246	L-lysine catabolic process to acetate
C2U31_RS22770	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_RS22775	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS22805	COG0519	Catalyzes the synthesis of GMP from XMP
C2U31_RS22805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2U31_RS22835	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C2U31_RS22855	COG2072	flavoprotein involved in K transport
C2U31_RS22860	COG0601	transmembrane transport
C2U31_RS22865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS22870	COG0444	Belongs to the ABC transporter superfamily
C2U31_RS22875	COG4608	Belongs to the ABC transporter superfamily
C2U31_RS22880	COG0747	negative chemotaxis
C2U31_RS22945	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
C2U31_RS22955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2U31_RS23010	COG0583	DNA-binding transcription factor activity
C2U31_RS23020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_RS23030	COG0477	Major facilitator Superfamily
C2U31_RS23110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U31_RS23135	COG0047	phosphoribosylformylglycinamidine synthase activity
C2U31_RS23135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2U31_RS23145	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C2U31_RS23145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C2U31_RS23150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2U31_RS23175	COG1132	(ABC) transporter
C2U31_RS23190	COG5265	(ABC) transporter
C2U31_RS23195	COG1280	lysine exporter protein (LysE YggA)
C2U31_RS23230	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_RS23235	COG2188	Transcriptional regulator
C2U31_RS23245	COG0494	nUDIX hydrolase
C2U31_RS23255	COG0583	DNA-binding transcription factor activity
C2U31_RS23260	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS23275	COG1024	Enoyl-CoA hydratase
C2U31_RS23280	COG5001	Diguanylate cyclase
C2U31_RS23290	COG0129	dihydroxy-acid dehydratase activity
C2U31_RS23310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS23340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C2U31_RS23360	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C2U31_RS23365	COG1335	isochorismatase
C2U31_RS23370	COG2309	aminopeptidase activity
C2U31_RS23375	COG0596	Alpha beta hydrolase
C2U31_RS23400	COG0583	DNA-binding transcription factor activity
C2U31_RS23405	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_RS23410	COG3246	L-lysine catabolic process to acetate
C2U31_RS23430	COG3043	anaerobic respiration
C2U31_RS23435	COG3005	denitrification pathway
C2U31_RS23440	COG4133	protoheme IX ABC transporter activity
C2U31_RS23460	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C2U31_RS23470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2U31_RS23475	COG3088	subunit of a heme lyase
C2U31_RS23490	COG3214	Protein conserved in bacteria
C2U31_RS23495	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS23505	COG0789	Transcriptional regulator
C2U31_RS23510	COG2814	Major facilitator Superfamily
C2U31_RS23555	COG0613	PHP domain protein
C2U31_RS23565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2U31_RS23575	COG0583	DNA-binding transcription factor activity
C2U31_RS23595	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C2U31_RS23620	COG1304	FMN binding
C2U31_RS23630	COG0737	Belongs to the 5'-nucleotidase family
C2U31_RS23635	COG4604	ABC transporter, ATP-binding protein
C2U31_RS23640	COG4605	iron ion homeostasis
C2U31_RS23645	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_RS23650	COG4607	ABC-type enterochelin transport system periplasmic component
C2U31_RS23655	COG4771	TonB-dependent receptor
C2U31_RS23660	COG0745	RESPONSE REGULATOR receiver
C2U31_RS23670	COG4771	TonB-dependent receptor
C2U31_RS23675	COG0084	hydrolase, TatD family'
C2U31_RS23680	COG1136	(ABC) transporter
C2U31_RS23700	COG2271	Major facilitator Superfamily
C2U31_RS23710	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS23715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2U31_RS23725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS23730	COG0243	molybdopterin cofactor binding
C2U31_RS23740	COG0183	Belongs to the thiolase family
C2U31_RS23745	COG1022	Amp-dependent synthetase and ligase
C2U31_RS23795	COG1803	Methylglyoxal synthase
C2U31_RS23800	COG2975	iron-sulfur cluster assembly
C2U31_RS23810	COG0443	Heat shock 70 kDa protein
C2U31_RS23815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C2U31_RS23820	COG0316	Belongs to the HesB IscA family
C2U31_RS23825	COG0822	iron-sulfur transferase activity
C2U31_RS23830	COG1104	cysteine desulfurase activity
C2U31_RS23840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2U31_RS23845	COG0556	nucleotide-excision repair
C2U31_RS23855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2U31_RS23860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2U31_RS23865	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2U31_RS23870	COG0740	serine-type endopeptidase activity
C2U31_RS23875	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2U31_RS23880	COG0501	Belongs to the peptidase M48B family
C2U31_RS23895	COG1278	Cold shock
C2U31_RS23905	COG1278	Cold shock
C2U31_RS23930	COG0251	oxidation-reduction process
C2U31_RS23940	COG0583	DNA-binding transcription factor activity
C2U31_RS23955	COG1309	transcriptional regulator
C2U31_RS23975	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C2U31_RS23980	COG3038	cytochrome b561
C2U31_RS24015	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_RS24020	COG0174	glutamine synthetase
C2U31_RS24050	COG0436	Aminotransferase
C2U31_RS24055	COG2171	N-acyltransferase activity
C2U31_RS24065	COG2890	protein-(glutamine-N5) methyltransferase activity
C2U31_RS24070	COG0488	(ABC) transporter
C2U31_RS24085	COG4771	TonB-dependent receptor
C2U31_RS24100	COG0210	DNA helicase
C2U31_RS24115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2U31_RS24115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U31_RS24125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2U31_RS24130	COG0196	riboflavin kinase activity
C2U31_RS24135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2U31_RS24140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2U31_RS24145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2U31_RS24165	COG2197	response regulator
C2U31_RS24185	COG3121	Chaperone
C2U31_RS24190	COG3188	usher protein
C2U31_RS24195	COG3121	Chaperone
C2U31_RS24225	COG1902	pentaerythritol trinitrate reductase activity
C2U31_RS24230	COG1126	abc transporter atp-binding protein
C2U31_RS24235	COG0765	amino acid transport
C2U31_RS24240	COG0765	amino acid transport
C2U31_RS24245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS24255	COG2423	ornithine cyclodeaminase activity
C2U31_RS24260	COG1764	response to oxidative stress
C2U31_RS24265	COG1914	H( )-stimulated, divalent metal cation uptake system
C2U31_RS24280	COG2271	Major facilitator Superfamily
C2U31_RS24290	COG1309	transcriptional regulator
C2U31_RS24320	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U31_RS24320	COG0506	proline dehydrogenase activity
C2U31_RS24320	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C2U31_RS24330	COG3008	intermembrane lipid transfer
C2U31_RS24335	COG2995	paraquat-inducible protein a
C2U31_RS24340	COG0542	response to heat
C2U31_RS24345	COG4953	penicillin-binding protein 1C
C2U31_RS24350	COG2373	Large extracellular alpha-helical protein
C2U31_RS24355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C2U31_RS24360	COG1278	Cold shock
C2U31_RS24370	COG0183	Belongs to the thiolase family
C2U31_RS24375	COG0038	chloride channel
C2U31_RS24385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2U31_RS24395	COG1570	exodeoxyribonuclease VII activity
C2U31_RS24400	COG0811	peptide transport
C2U31_RS24410	COG1663	tetraacyldisaccharide 4'-kinase activity
C2U31_RS24420	COG2835	tetraacyldisaccharide 4'-kinase activity
C2U31_RS24425	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C2U31_RS24430	COG0563	adenylate kinase activity
C2U31_RS24440	COG0728	peptidoglycan biosynthetic process
C2U31_RS24450	COG0268	Binds directly to 16S ribosomal RNA
C2U31_RS24455	COG0583	DNA-binding transcription factor activity
C2U31_RS24470	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS24480	COG2186	Transcriptional regulator
C2U31_RS24495	COG2814	Major facilitator Superfamily
C2U31_RS24500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2U31_RS24510	COG0439	Biotin carboxylase
C2U31_RS24515	COG0511	ligase activity, forming carbon-carbon bonds
C2U31_RS24520	COG0511	ligase activity, forming carbon-carbon bonds
C2U31_RS24520	COG5016	pyruvate
C2U31_RS24530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2U31_RS24555	COG1846	Transcriptional regulator
C2U31_RS24560	COG3384	dioxygenase
C2U31_RS24565	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_RS24580	COG3971	2-oxopent-4-enoate hydratase activity
C2U31_RS24590	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS24595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2U31_RS24605	COG1562	ergosterol biosynthetic process
C2U31_RS24610	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C2U31_RS24615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2U31_RS24635	COG1477	protein flavinylation
C2U31_RS24640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2U31_RS24650	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2U31_RS24655	COG0583	DNA-binding transcription factor activity
C2U31_RS24665	COG5564	TIM-barrel signal transduction protein
C2U31_RS24670	COG5441	Belongs to the UPF0261 family
C2U31_RS24700	COG1802	Transcriptional regulator
C2U31_RS24710	COG0747	negative chemotaxis
C2U31_RS24735	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U31_RS24745	COG0542	response to heat
C2U31_RS24755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2U31_RS24765	COG0477	Major facilitator Superfamily
C2U31_RS24775	COG0494	nUDIX hydrolase
C2U31_RS24790	COG0443	Heat shock 70 kDa protein
C2U31_RS24805	COG2197	response regulator
C2U31_RS24810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2U31_RS24830	COG0028	Belongs to the TPP enzyme family
C2U31_RS24840	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_RS24845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2U31_RS24855	COG0601	transmembrane transport
C2U31_RS24860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS24865	COG4172	Belongs to the ABC transporter superfamily
C2U31_RS24885	COG1609	Transcriptional regulator
C2U31_RS24890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C2U31_RS24895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C2U31_RS24900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2U31_RS24905	COG0129	dihydroxy-acid dehydratase activity
C2U31_RS24920	COG1051	belongs to the nudix hydrolase family
C2U31_RS24950	COG0135	phosphoribosylanthranilate isomerase activity
C2U31_RS24955	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C2U31_RS24960	COG0101	tRNA pseudouridine synthase activity
C2U31_RS24970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2U31_RS24990	COG1538	Outer membrane efflux protein
C2U31_RS25000	COG2274	protein secretion by the type I secretion system
C2U31_RS25005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_RS25030	COG0583	DNA-binding transcription factor activity
C2U31_RS25035	COG2267	carboxylic ester hydrolase activity
C2U31_RS25040	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS25045	COG4783	chaperone-mediated protein folding
C2U31_RS25050	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2U31_RS25065	COG2205	protein histidine kinase activity
C2U31_RS25075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2U31_RS25085	COG1295	ribonuclease BN
C2U31_RS25095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2U31_RS25125	COG4964	Belongs to the GSP D family
C2U31_RS25160	COG0640	Transcriptional regulator
C2U31_RS25165	COG2755	lipolytic protein G-D-S-L family
C2U31_RS25165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2U31_RS25170	COG4977	sequence-specific DNA binding
C2U31_RS25175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2U31_RS25185	COG2205	protein histidine kinase activity
C2U31_RS25195	COG2205	protein histidine kinase activity
C2U31_RS25200	COG0745	RESPONSE REGULATOR receiver
C2U31_RS25220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_RS25230	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C2U31_RS25305	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2U31_RS25315	COG1609	Transcriptional regulator
C2U31_RS25320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2U31_RS25320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2U31_RS25325	COG1105	Belongs to the carbohydrate kinase PfkB family
C2U31_RS25330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U31_RS25330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2U31_RS25340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C2U31_RS25345	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2U31_RS25350	COG0330	HflC and HflK could
C2U31_RS25355	COG0330	HflC and HflK could
C2U31_RS25360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2U31_RS25365	COG1923	regulation of RNA biosynthetic process
C2U31_RS25375	COG1160	GTP binding
C2U31_RS25380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2U31_RS25385	COG2976	Protein conserved in bacteria
C2U31_RS25405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2U31_RS25410	COG0105	UTP biosynthetic process
C2U31_RS25415	COG0525	valine-tRNA ligase activity
C2U31_RS25420	COG0336	Belongs to the RNA methyltransferase TrmD family
C2U31_RS25425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2U31_RS25430	COG0228	four-way junction DNA binding
C2U31_RS25435	COG0425	Belongs to the sulfur carrier protein TusA family
C2U31_RS25440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U31_RS25455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_RS25465	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2U31_RS25470	COG2076	Multidrug Resistance protein
C2U31_RS25475	COG0633	Ferredoxin
C2U31_RS25475	COG3217	Mosc domain protein beta barrel domain protein
C2U31_RS25480	COG5285	phytanoyl-CoA dioxygenase
C2U31_RS25485	COG0662	Cupin 2, conserved barrel domain protein
C2U31_RS25495	COG0456	acetyltransferase
C2U31_RS25510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2U31_RS25515	COG2311	Membrane
C2U31_RS25535	COG0187	DNA topoisomerase II activity
C2U31_RS25545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2U31_RS25560	COG1902	pentaerythritol trinitrate reductase activity
C2U31_RS25560	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2U31_RS25565	COG0247	lactate metabolic process
C2U31_RS25565	COG2181	nitrate reductase activity
C2U31_RS25570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2U31_RS25595	COG1063	alcohol dehydrogenase
C2U31_RS25600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2U31_RS25610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2U31_RS25635	COG0625	glutathione transferase activity
C2U31_RS25640	COG0477	Major facilitator Superfamily
C2U31_RS25655	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C2U31_RS25660	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2U31_RS25680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2U31_RS25690	COG3391	amine dehydrogenase activity
C2U31_RS25720	COG1846	Transcriptional regulator
C2U31_RS25730	COG1566	PFAM secretion protein HlyD family protein
C2U31_RS25735	COG2814	Major facilitator Superfamily
C2U31_RS25745	COG0473	3-isopropylmalate dehydrogenase activity
C2U31_RS25750	COG0433	COG0433 Predicted ATPase
C2U31_RS25755	COG0217	transcriptional regulatory protein
C2U31_RS25760	COG0151	Belongs to the GarS family
C2U31_RS25770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2U31_RS25775	COG0799	negative regulation of ribosome biogenesis
C2U31_RS25780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2U31_RS25790	COG1301	dicarboxylic acid transport
C2U31_RS25795	COG4191	Histidine kinase
C2U31_RS25800	COG2204	response regulator
C2U31_RS25815	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2U31_RS25825	COG3384	dioxygenase
C2U31_RS25840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2U31_RS25895	COG4964	Belongs to the GSP D family
C2U31_RS25945	COG1846	Transcriptional regulator
C2U31_RS25955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2U31_RS25960	COG0601	transmembrane transport
C2U31_RS25975	COG0598	Magnesium transport protein CorA
C2U31_RS25995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2U31_RS26020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2U31_RS26025	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_RS26035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U31_RS26040	COG1045	serine acetyltransferase
C2U31_RS26045	COG0166	Belongs to the GPI family
C2U31_RS26055	COG3206	protein involved in exopolysaccharide biosynthesis
C2U31_RS26055	COG0489	protein tyrosine kinase activity
C2U31_RS26065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2U31_RS26090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2U31_RS26115	COG0463	Glycosyl transferase, family 2
C2U31_RS26120	COG0110	maltose O-acetyltransferase activity
C2U31_RS26125	COG0297	glycogen (starch) synthase activity
C2U31_RS26130	COG2197	response regulator
C2U31_RS26135	COG2197	response regulator
C2U31_RS26150	COG1960	acyl-CoA dehydrogenase activity
C2U31_RS26160	COG1024	Enoyl-CoA hydratase
C2U31_RS26160	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_RS26170	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2U31_RS26170	COG1024	Enoyl-CoA hydratase
C2U31_RS26175	COG0183	Belongs to the thiolase family
C2U31_RS26190	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_RS26200	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS26210	COG1132	(ABC) transporter
C2U31_RS26215	COG0318	PFAM AMP-dependent synthetase and ligase
C2U31_RS26220	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2U31_RS26225	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2U31_RS26230	COG1024	Enoyl-CoA hydratase
C2U31_RS26240	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS26250	COG1414	Transcriptional regulator
C2U31_RS26260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2U31_RS26280	COG0583	DNA-binding transcription factor activity
C2U31_RS26290	COG0456	acetyltransferase
C2U31_RS26325	COG0037	tRNA processing
C2U31_RS26330	COG0825	malonyl-CoA metabolic process
C2U31_RS26340	COG0215	cysteine-tRNA ligase activity
C2U31_RS26350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2U31_RS26355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C2U31_RS26365	COG1968	undecaprenyl-diphosphatase activity
C2U31_RS26370	COG1253	flavin adenine dinucleotide binding
C2U31_RS26375	COG1253	flavin adenine dinucleotide binding
C2U31_RS26385	COG4263	nitrous-oxide reductase activity
C2U31_RS26400	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2U31_RS26415	COG0483	inositol monophosphate 1-phosphatase activity
C2U31_RS26420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C2U31_RS26440	COG0668	transmembrane transport
C2U31_RS26475	COG0431	NADPH-dependent FMN reductase
C2U31_RS26485	COG3360	Dodecin
C2U31_RS26495	COG0583	DNA-binding transcription factor activity
C2U31_RS26500	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS26615	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2U31_RS26620	COG2850	peptidyl-arginine hydroxylation
C2U31_RS26630	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C2U31_RS26635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2U31_RS26640	COG1994	Peptidase M50
C2U31_RS26645	COG0009	L-threonylcarbamoyladenylate synthase
C2U31_RS26650	COG2321	neutral zinc metallopeptidase
C2U31_RS26685	COG2808	Putative FMN-binding domain
C2U31_RS26700	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2U31_RS26730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U31_RS26735	COG2084	Dehydrogenase
C2U31_RS26760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2U31_RS26765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS26795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2U31_RS26800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2U31_RS26810	COG0657	acetylesterase activity
C2U31_RS26815	COG2072	flavoprotein involved in K transport
C2U31_RS26845	COG0765	amino acid transport
C2U31_RS26860	COG1126	abc transporter atp-binding protein
C2U31_RS26865	COG1012	belongs to the aldehyde dehydrogenase family
C2U31_RS26870	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
C2U31_RS26890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2U31_RS26960	COG1396	sequence-specific DNA binding
C2U31_RS26975	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS26990	COG1309	transcriptional regulator
C2U31_RS27000	COG1785	Belongs to the alkaline phosphatase family
C2U31_RS27065	COG1917	Cupin 2, conserved barrel domain protein
C2U31_RS27090	COG1137	ATPase activity
C2U31_RS27105	COG0431	NADPH-dependent FMN reductase
C2U31_RS27110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U31_RS27115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2U31_RS27120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U31_RS27135	COG0436	Aminotransferase
C2U31_RS27140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2U31_RS27185	COG0668	transmembrane transport
C2U31_RS27190	COG0745	RESPONSE REGULATOR receiver
C2U31_RS27215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2U31_RS27265	COG0577	efflux transmembrane transporter activity
C2U31_RS27265	COG1136	(ABC) transporter
C2U31_RS27280	COG2205	protein histidine kinase activity
C2U31_RS27285	COG0745	RESPONSE REGULATOR receiver
C2U31_RS27305	COG3842	ATPase activity
C2U31_RS27310	COG4208	sulfate ABC transporter
C2U31_RS27315	COG0583	DNA-binding transcription factor activity
C2U31_RS27320	COG1595	DNA-templated transcription, initiation
C2U31_RS27325	COG3712	iron ion homeostasis
C2U31_RS27330	COG4774	siderophore transport
C2U31_RS27335	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C2U31_RS27340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2U31_RS27345	COG3958	Transketolase
C2U31_RS27350	COG3959	Transketolase, thiamine diphosphate binding domain
C2U31_RS27355	COG1802	Transcriptional regulator
C2U31_RS27360	COG0371	Dehydrogenase
C2U31_RS27365	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS27390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2U31_RS27390	COG4221	oxidoreductase activity
C2U31_RS27390	COG0604	alcohol dehydrogenase
C2U31_RS27390	COG3321	synthase
C2U31_RS27395	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS27400	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
C2U31_RS27410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2U31_RS27420	COG0500	methyltransferase
C2U31_RS27425	COG1595	DNA-templated transcription, initiation
C2U31_RS27435	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
C2U31_RS27455	COG0667	Aldo Keto reductase
C2U31_RS27460	COG2207	Transcriptional regulator
C2U31_RS27470	COG0765	amino acid transport
C2U31_RS27480	COG1126	abc transporter atp-binding protein
C2U31_RS27490	COG0251	oxidation-reduction process
C2U31_RS27500	COG1609	Transcriptional regulator
C2U31_RS27505	COG0583	DNA-binding transcription factor activity
C2U31_RS27510	COG1335	isochorismatase
C2U31_RS27545	COG0583	DNA-binding transcription factor activity
C2U31_RS27550	COG2814	Major facilitator Superfamily
C2U31_RS27585	COG1522	sequence-specific DNA binding
C2U31_RS27590	COG2423	ornithine cyclodeaminase activity
C2U31_RS27600	COG5001	Diguanylate cyclase
C2U31_RS27600	COG3706	GGDEF domain
C2U31_RS27600	COG2203	Gaf domain
C2U31_RS27600	COG4251	negative regulation of phosphorylation
C2U31_RS27610	COG0477	Major facilitator Superfamily
C2U31_RS27625	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS27630	COG0477	Major facilitator Superfamily
C2U31_RS27640	COG0583	DNA-binding transcription factor activity
C2U31_RS27650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2U31_RS27685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2U31_RS27695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2U31_RS27700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C2U31_RS27705	COG1534	Rna-binding protein
C2U31_RS27710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2U31_RS27715	COG0840	transmembrane signaling receptor activity
C2U31_RS27720	COG2233	PERMEase
C2U31_RS27740	COG0300	oxidoreductase activity
C2U31_RS27750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2U31_RS27755	COG0505	Belongs to the CarA family
C2U31_RS27760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2U31_RS27770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS27780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U31_RS27785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C2U31_RS27800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2U31_RS27820	COG1074	ATP-dependent DNA helicase activity
C2U31_RS27840	COG1686	Belongs to the peptidase S11 family
C2U31_RS27860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2U31_RS27865	COG4974	Belongs to the 'phage' integrase family
C2U31_RS27875	COG0028	Belongs to the TPP enzyme family
C2U31_RS27890	COG2030	dehydratase
C2U31_RS27895	COG0028	Belongs to the TPP enzyme family
C2U31_RS27900	COG1126	abc transporter atp-binding protein
C2U31_RS27905	COG0765	amino acid transport
C2U31_RS27915	COG0010	Belongs to the arginase family
C2U31_RS27925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS27965	COG0583	DNA-binding transcription factor activity
C2U31_RS27970	COG0427	acetyl-CoA hydrolase
C2U31_RS27975	COG0583	DNA-binding transcription factor activity
C2U31_RS27980	COG1511	domain protein
C2U31_RS27980	COG3264	Mechanosensitive ion channel
C2U31_RS28010	COG2176	DNA-directed DNA polymerase activity
C2U31_RS28035	COG3842	ATPase activity
C2U31_RS28040	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2U31_RS28045	COG0395	ABC-type sugar transport system, permease component
C2U31_RS28050	COG3938	Belongs to the proline racemase family
C2U31_RS28055	COG0517	IMP dehydrogenase activity
C2U31_RS28095	COG0009	L-threonylcarbamoyladenylate synthase
C2U31_RS28100	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2U31_RS28105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2U31_RS28110	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2U31_RS28115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2U31_RS28135	COG1301	dicarboxylic acid transport
C2U31_RS28150	COG3454	Phosphonate metabolism
C2U31_RS28155	COG4778	phosphonate C-P lyase system protein PhnL
C2U31_RS28160	COG4107	phosphonate C-P lyase system protein PhnK
C2U31_RS28165	COG3627	carbon phosphorus lyase activity
C2U31_RS28170	COG3626	phosphonate metabolism
C2U31_RS28180	COG3624	Phosphonate C-P lyase system protein PhnG
C2U31_RS28185	COG2188	Transcriptional regulator
C2U31_RS28190	COG3454	Phosphonate metabolism
C2U31_RS28195	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C2U31_RS28200	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C2U31_RS28205	COG0583	DNA-binding transcription factor activity
C2U31_RS28215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2U31_RS28230	COG3253	May function as heme-dependent peroxidase
C2U31_RS28245	COG0405	Gamma-glutamyltransferase
C2U31_RS28260	COG3639	organic phosphonate transmembrane transporter activity
C2U31_RS28265	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C2U31_RS28270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2U31_RS28290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2U31_RS28300	COG0739	heme binding
C2U31_RS28310	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U31_RS28315	COG0306	phosphate transporter
C2U31_RS28345	COG0456	acetyltransferase
C2U31_RS28345	COG0454	-acetyltransferase
C2U31_RS28355	COG0625	glutathione transferase activity
C2U31_RS28375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2U31_RS28380	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2U31_RS28390	COG0126	phosphoglycerate kinase activity
C2U31_RS28395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2U31_RS28400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2U31_RS28410	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2U31_RS28415	COG2732	(Barnase) inhibitor
C2U31_RS28425	COG0280	phosphate acetyltransferase
C2U31_RS28425	COG0281	malic enzyme
C2U31_RS28435	COG0436	Aminotransferase
C2U31_RS28440	COG0741	lytic transglycosylase activity
C2U31_RS28445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2U31_RS28480	COG4575	ribosome binding
C2U31_RS28490	COG0243	molybdopterin cofactor binding
C2U31_RS28500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2U31_RS28505	COG1116	anion transmembrane transporter activity
C2U31_RS28510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS28515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2U31_RS28525	COG1648	precorrin-2 dehydrogenase activity
C2U31_RS28525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2U31_RS28530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2U31_RS28535	COG2027	D-alanyl-D-alanine carboxypeptidase
C2U31_RS28550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_RS28560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2U31_RS28565	COG0343	queuine tRNA-ribosyltransferase activity
C2U31_RS28570	COG1862	Preprotein translocase
C2U31_RS28575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U31_RS28580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2U31_RS28605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2U31_RS28615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2U31_RS28620	COG1702	phosphate starvation-inducible protein PhoH
C2U31_RS28625	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2U31_RS28630	COG4535	Mg2 and Co2 transporter CorC
C2U31_RS28635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C2U31_RS28640	COG0667	Aldo Keto reductase
C2U31_RS28675	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2U31_RS28680	COG0697	spore germination
C2U31_RS28690	COG0678	peroxiredoxin activity
C2U31_RS28700	COG0412	Dienelactone hydrolase
C2U31_RS28710	COG0315	cyclic pyranopterin monophosphate synthase activity
C2U31_RS28725	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2U31_RS28735	COG0746	molybdenum cofactor guanylyltransferase activity
C2U31_RS28740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2U31_RS28760	COG3383	formate dehydrogenase (NAD+) activity
C2U31_RS28765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2U31_RS28780	COG2161	toxin-antitoxin pair type II binding
C2U31_RS28805	COG0583	DNA-binding transcription factor activity
C2U31_RS28810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2U31_RS28845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2U31_RS28855	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS28875	COG2828	Protein conserved in bacteria
C2U31_RS28880	COG0583	DNA-binding transcription factor activity
C2U31_RS28885	COG0456	acetyltransferase
C2U31_RS28925	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2U31_RS28950	COG4774	siderophore transport
C2U31_RS28970	COG4585	Histidine kinase
C2U31_RS28975	COG0671	phosphoesterase, PA-phosphatase related
C2U31_RS28985	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2U31_RS28990	COG1666	GTP binding
C2U31_RS29000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2U31_RS29005	COG4558	Periplasmic binding protein
C2U31_RS29010	COG3720	iron ion transport
C2U31_RS29020	COG3712	iron ion homeostasis
C2U31_RS29025	COG1595	DNA-templated transcription, initiation
C2U31_RS29040	COG2378	regulation of single-species biofilm formation
C2U31_RS29070	COG1113	amino acid transport
C2U31_RS29080	COG1522	sequence-specific DNA binding
C2U31_RS29085	COG1272	protein, Hemolysin III
C2U31_RS29090	COG3191	aminopeptidase activity
C2U31_RS29095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2U31_RS29100	COG0765	amino acid transport
C2U31_RS29105	COG1126	abc transporter atp-binding protein
C2U31_RS29110	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS29150	COG1999	signal sequence binding
C2U31_RS29170	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C2U31_RS29180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U31_RS29185	COG1845	cytochrome c oxidase, subunit III
C2U31_RS29190	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U31_RS29230	COG0280	phosphate acetyltransferase
C2U31_RS29230	COG0281	malic enzyme
C2U31_RS29245	COG0697	spore germination
C2U31_RS29265	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS29270	COG2267	carboxylic ester hydrolase activity
C2U31_RS29285	COG1396	sequence-specific DNA binding
C2U31_RS29290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2U31_RS29305	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS29310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2U31_RS29320	COG0657	acetylesterase activity
C2U31_RS29335	COG1309	transcriptional regulator
C2U31_RS29345	COG5001	Diguanylate cyclase
C2U31_RS29350	COG0330	HflC and HflK could
C2U31_RS29365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS29370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C2U31_RS29395	COG2807	transmembrane transport
C2U31_RS29400	COG2207	Transcriptional regulator
C2U31_RS29405	COG4106	trans-aconitate 2-methyltransferase activity
C2U31_RS29420	COG0583	DNA-binding transcription factor activity
C2U31_RS29455	COG0477	Major facilitator Superfamily
C2U31_RS29460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2U31_RS29465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2U31_RS29470	COG1845	cytochrome c oxidase, subunit III
C2U31_RS29475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2U31_RS29480	COG3346	SURF1 family
C2U31_RS29515	COG0625	glutathione transferase activity
C2U31_RS29540	COG0784	Response regulator, receiver
C2U31_RS29540	COG2205	protein histidine kinase activity
C2U31_RS29555	COG2197	response regulator
C2U31_RS29560	COG3161	chorismate lyase activity
C2U31_RS29610	COG0006	proline dipeptidase activity
C2U31_RS29615	COG0583	DNA-binding transcription factor activity
C2U31_RS29625	COG0667	Aldo Keto reductase
C2U31_RS29630	COG0023	Translation Initiation Factor
C2U31_RS29645	COG0840	transmembrane signaling receptor activity
C2U31_RS29650	COG0840	transmembrane signaling receptor activity
C2U31_RS29655	COG2706	6-phosphogluconolactonase activity
C2U31_RS29660	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS29680	COG1402	creatininase
C2U31_RS29695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2U31_RS29715	COG2814	Major facilitator Superfamily
C2U31_RS29730	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C2U31_RS29740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2U31_RS29745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2U31_RS29750	COG0697	spore germination
C2U31_RS29805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS29810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2U31_RS29820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2U31_RS29870	COG2197	response regulator
C2U31_RS29905	COG4172	Belongs to the ABC transporter superfamily
C2U31_RS29910	COG0444	Belongs to the ABC transporter superfamily
C2U31_RS29920	COG0601	transmembrane transport
C2U31_RS29925	COG0747	negative chemotaxis
C2U31_RS29965	COG3485	protocatechuate 3,4-dioxygenase
C2U31_RS30000	COG1733	regulation of RNA biosynthetic process
C2U31_RS30015	COG4948	Mandelate Racemase Muconate Lactonizing
C2U31_RS30020	COG2197	response regulator
C2U31_RS30030	COG2814	Major facilitator Superfamily
C2U31_RS30050	COG3246	L-lysine catabolic process to acetate
C2U31_RS30055	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS30115	COG1595	DNA-templated transcription, initiation
C2U31_RS30125	COG2807	transmembrane transport
C2U31_RS30130	COG0590	tRNA wobble adenosine to inosine editing
C2U31_RS30140	COG3181	Tripartite tricarboxylate transporter family receptor
C2U31_RS30145	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2U31_RS30150	COG4948	Mandelate Racemase Muconate Lactonizing
C2U31_RS30175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2U31_RS30190	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2U31_RS30205	COG2124	cytochrome p450
C2U31_RS30225	COG2204	response regulator
C2U31_RS30230	COG2610	gluconate transmembrane transporter activity
C2U31_RS30235	COG1028	Short-chain dehydrogenase reductase Sdr
C2U31_RS30265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2U31_RS30270	COG0459	protein refolding
C2U31_RS30285	COG0246	Mannitol dehydrogenase
C2U31_RS30290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2U31_RS30295	COG1252	NADH dehydrogenase
C2U31_RS30300	COG0284	orotidine-5'-phosphate decarboxylase activity
C2U31_RS30305	COG1546	Belongs to the CinA family
C2U31_RS30320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2U31_RS30325	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity