locus-tag	class	description
CVS48_RS00035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS48_RS00045	COG1185	polyribonucleotide nucleotidyltransferase activity
CVS48_RS00050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CVS48_RS00060	COG1183	phosphatidylcholine synthase activity
CVS48_RS00065	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CVS48_RS00070	COG0440	acetolactate synthase activity
CVS48_RS00075	COG0028	Belongs to the TPP enzyme family
CVS48_RS00080	COG1289	transmembrane transporter activity
CVS48_RS00090	COG3022	response to hydroperoxide
CVS48_RS00095	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS00130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CVS48_RS00135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVS48_RS00140	COG0477	Major facilitator Superfamily
CVS48_RS00190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CVS48_RS00195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CVS48_RS00200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVS48_RS00210	COG0747	negative chemotaxis
CVS48_RS00215	COG0601	transmembrane transport
CVS48_RS00235	COG1737	Transcriptional regulator
CVS48_RS00240	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CVS48_RS00245	COG0251	oxidation-reduction process
CVS48_RS00250	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CVS48_RS00255	COG1674	ftsk spoiiie
CVS48_RS00260	COG0492	ferredoxin-NADP+ reductase activity
CVS48_RS00265	COG1193	negative regulation of DNA recombination
CVS48_RS00285	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVS48_RS00300	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CVS48_RS00305	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CVS48_RS00310	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CVS48_RS00315	COG2205	protein histidine kinase activity
CVS48_RS00320	COG0745	RESPONSE REGULATOR receiver
CVS48_RS00335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_RS00340	COG0840	transmembrane signaling receptor activity
CVS48_RS00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVS48_RS00395	COG0612	Peptidase, M16
CVS48_RS00410	COG0484	heat shock protein binding
CVS48_RS00415	COG0443	Heat shock 70 kDa protein
CVS48_RS00425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CVS48_RS00435	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CVS48_RS00440	COG1420	regulation of RNA biosynthetic process
CVS48_RS00450	COG0497	DNA recombination
CVS48_RS00455	COG0735	belongs to the Fur family
CVS48_RS00460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS48_RS00480	COG0582	viral genome integration into host DNA
CVS48_RS00530	COG0745	RESPONSE REGULATOR receiver
CVS48_RS00535	COG5002	protein histidine kinase activity
CVS48_RS00545	COG0640	Transcriptional regulator
CVS48_RS00560	COG0798	PFAM Bile acid sodium symporter
CVS48_RS00570	COG1695	Transcriptional regulator
CVS48_RS00650	COG2003	Belongs to the UPF0758 family
CVS48_RS00705	COG3311	Transcriptional regulator
CVS48_RS00710	COG1569	PIN domain
CVS48_RS00715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVS48_RS00865	COG0789	Transcriptional regulator
CVS48_RS00910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CVS48_RS00920	COG0789	Transcriptional regulator
CVS48_RS00935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CVS48_RS00940	COG0629	single-stranded DNA binding
CVS48_RS01000	COG3397	chitin binding
CVS48_RS01005	COG3397	chitin binding
CVS48_RS01015	COG2205	protein histidine kinase activity
CVS48_RS01020	COG0745	RESPONSE REGULATOR receiver
CVS48_RS01035	COG2165	general secretion pathway protein
CVS48_RS01040	COG1450	Type ii and iii secretion system protein
CVS48_RS01065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS48_RS01070	COG1459	type II secretion system
CVS48_RS01110	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS48_RS01110	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CVS48_RS01125	COG1063	alcohol dehydrogenase
CVS48_RS01150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CVS48_RS01155	COG0247	lactate metabolic process
CVS48_RS01155	COG2181	nitrate reductase activity
CVS48_RS01160	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS48_RS01160	COG1902	pentaerythritol trinitrate reductase activity
CVS48_RS01175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVS48_RS01195	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS01210	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS01280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CVS48_RS01285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CVS48_RS01290	COG0167	dihydroorotate dehydrogenase activity
CVS48_RS01305	COG1414	Transcriptional regulator
CVS48_RS01310	COG1058	Belongs to the CinA family
CVS48_RS01310	COG1546	Belongs to the CinA family
CVS48_RS01325	COG0513	Belongs to the DEAD box helicase family
CVS48_RS01350	COG0429	hydrolase of the alpha beta-hydrolase fold
CVS48_RS01355	COG4783	chaperone-mediated protein folding
CVS48_RS01375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CVS48_RS01390	COG0006	proline dipeptidase activity
CVS48_RS01400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_RS01420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CVS48_RS01425	COG0632	four-way junction helicase activity
CVS48_RS01430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVS48_RS01440	COG2255	four-way junction helicase activity
CVS48_RS01445	COG4191	Histidine kinase
CVS48_RS01460	COG0514	ATP-dependent DNA helicase (RecQ)
CVS48_RS01470	COG1271	oxidase subunit
CVS48_RS01475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS48_RS01480	COG0850	regulation of cytokinetic process
CVS48_RS01485	COG2894	cell division
CVS48_RS01490	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CVS48_RS01515	COG0488	(ABC) transporter
CVS48_RS01530	COG4608	Belongs to the ABC transporter superfamily
CVS48_RS01535	COG0444	Belongs to the ABC transporter superfamily
CVS48_RS01540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS01545	COG0601	transmembrane transport
CVS48_RS01550	COG0747	negative chemotaxis
CVS48_RS01575	COG4638	Rieske (2fe-2S)
CVS48_RS01600	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CVS48_RS01605	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS01630	COG1216	Glycosyl transferase, family 2
CVS48_RS01630	COG0463	Glycosyl transferase, family 2
CVS48_RS01645	COG0800	Aldolase
CVS48_RS01655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CVS48_RS01695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CVS48_RS01700	COG1538	Outer membrane efflux protein
CVS48_RS01705	COG1136	(ABC) transporter
CVS48_RS01705	COG0577	efflux transmembrane transporter activity
CVS48_RS01710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS48_RS01725	COG0259	pyridoxamine-phosphate oxidase activity
CVS48_RS01735	COG0579	oxidoreductase
CVS48_RS01745	COG0583	DNA-binding transcription factor activity
CVS48_RS01750	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS01755	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS01760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS01765	COG0531	amino acid
CVS48_RS01770	COG0405	Gamma-glutamyltransferase
CVS48_RS01780	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS01790	COG0114	fumarate hydratase activity
CVS48_RS01795	COG0802	atpase or kinase
CVS48_RS01800	COG0860	N-Acetylmuramoyl-L-alanine amidase
CVS48_RS01805	COG0586	Pfam SNARE associated Golgi protein
CVS48_RS01810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CVS48_RS01815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CVS48_RS01820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CVS48_RS01835	COG0617	tRNA 3'-terminal CCA addition
CVS48_RS01840	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CVS48_RS01845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS48_RS01850	COG2301	Belongs to the HpcH HpaI aldolase family
CVS48_RS01860	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CVS48_RS01865	COG0583	DNA-binding transcription factor activity
CVS48_RS01870	COG1024	Enoyl-CoA hydratase
CVS48_RS01880	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS01895	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS01910	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS01920	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS01925	COG2030	dehydratase
CVS48_RS01930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS01945	COG1024	Enoyl-CoA hydratase
CVS48_RS01950	COG0752	glycyl-tRNA synthetase alpha subunit
CVS48_RS01955	COG0751	glycine-tRNA ligase activity
CVS48_RS01960	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CVS48_RS01965	COG0204	Acyl-transferase
CVS48_RS01980	COG0242	peptide deformylase activity
CVS48_RS01990	COG0700	Nucleoside recognition
CVS48_RS01995	COG0469	pyruvate kinase activity
CVS48_RS02000	COG1929	Belongs to the glycerate kinase type-1 family
CVS48_RS02005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CVS48_RS02010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS48_RS02025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVS48_RS02035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_RS02050	COG2154	pterin-4-alpha-carbinolamine dehydratase
CVS48_RS02220	COG0330	HflC and HflK could
CVS48_RS02240	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS02245	COG1309	transcriptional regulator
CVS48_RS02255	COG2982	Protein involved in outer membrane biogenesis
CVS48_RS02260	COG1368	sulfuric ester hydrolase activity
CVS48_RS02265	COG2818	Glycosylase
CVS48_RS02280	COG0735	belongs to the Fur family
CVS48_RS02290	COG0583	DNA-binding transcription factor activity
CVS48_RS02295	COG0840	transmembrane signaling receptor activity
CVS48_RS02325	COG2011	ABC-type metal ion transport system permease component
CVS48_RS02330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CVS48_RS02335	COG1501	Belongs to the glycosyl hydrolase 31 family
CVS48_RS02340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CVS48_RS02340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_RS02345	COG0483	inositol monophosphate 1-phosphatase activity
CVS48_RS02350	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS02355	COG1473	amidohydrolase
CVS48_RS02365	COG2855	membrane
CVS48_RS02375	COG2239	Acts as a magnesium transporter
CVS48_RS02390	COG1522	sequence-specific DNA binding
CVS48_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS02400	COG0028	Belongs to the TPP enzyme family
CVS48_RS02415	COG2801	Transposase and inactivated derivatives
CVS48_RS02415	COG3415	Transposase
CVS48_RS02425	COG0653	protein targeting
CVS48_RS02430	COG0739	heme binding
CVS48_RS02440	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CVS48_RS02445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CVS48_RS02455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CVS48_RS02460	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVS48_RS02465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVS48_RS02470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CVS48_RS02480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CVS48_RS02485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS48_RS02490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVS48_RS02500	COG3116	cell division
CVS48_RS02505	COG0275	rRNA processing
CVS48_RS02510	COG2001	Belongs to the MraZ family
CVS48_RS02520	COG0488	(ABC) transporter
CVS48_RS02525	COG0418	dihydroorotase activity
CVS48_RS02530	COG1473	amidohydrolase
CVS48_RS02575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS48_RS02580	COG4654	Cytochrome c, class I
CVS48_RS02585	COG0129	dihydroxy-acid dehydratase activity
CVS48_RS02625	COG2084	Dehydrogenase
CVS48_RS02640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS48_RS02675	COG0824	Thioesterase
CVS48_RS02680	COG0811	peptide transport
CVS48_RS02685	COG0848	biopolymer transport protein
CVS48_RS02695	COG0823	Involved in the tonB-independent uptake of proteins
CVS48_RS02710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS48_RS02715	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CVS48_RS02730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CVS48_RS02745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_RS02750	COG0697	spore germination
CVS48_RS02775	COG0583	DNA-binding transcription factor activity
CVS48_RS02790	COG0463	Glycosyl transferase, family 2
CVS48_RS02800	COG0786	glutamate:sodium symporter activity
CVS48_RS02815	COG1671	Belongs to the UPF0178 family
CVS48_RS02825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CVS48_RS02830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS48_RS02840	COG0328	RNA-DNA hybrid ribonuclease activity
CVS48_RS02845	COG2226	methyltransferase
CVS48_RS02850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS48_RS02855	COG1388	LysM domain
CVS48_RS02855	COG0741	lytic transglycosylase activity
CVS48_RS02875	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS02900	COG3188	usher protein
CVS48_RS02910	COG2197	response regulator
CVS48_RS02935	COG2719	SpoVR family
CVS48_RS02940	COG2718	Belongs to the UPF0229 family
CVS48_RS02945	COG2766	serine protein kinase
CVS48_RS02950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVS48_RS02950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVS48_RS02965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CVS48_RS02970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVS48_RS02975	COG1881	PFAM PEBP family protein
CVS48_RS02980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CVS48_RS02995	COG0316	Belongs to the HesB IscA family
CVS48_RS03005	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CVS48_RS03010	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CVS48_RS03015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CVS48_RS03030	COG4177	L-phenylalanine transmembrane transporter activity
CVS48_RS03035	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_RS03045	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CVS48_RS03050	COG0312	modulator of DNA gyrase
CVS48_RS03055	COG3028	Belongs to the UPF0307 family
CVS48_RS03070	COG1116	anion transmembrane transporter activity
CVS48_RS03075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_RS03080	COG1335	isochorismatase
CVS48_RS03085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS48_RS03085	COG1042	CoA-binding domain protein
CVS48_RS03085	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS48_RS03090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS48_RS03095	COG2814	Major facilitator Superfamily
CVS48_RS03105	COG1522	sequence-specific DNA binding
CVS48_RS03135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVS48_RS03140	COG1696	Membrane protein involved in D-alanine export
CVS48_RS03165	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CVS48_RS03165	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CVS48_RS03175	COG2264	protein methyltransferase activity
CVS48_RS03180	COG0439	Biotin carboxylase
CVS48_RS03185	COG0511	ligase activity, forming carbon-carbon bonds
CVS48_RS03190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CVS48_RS03195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS48_RS03200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVS48_RS03205	COG3150	esterase
CVS48_RS03210	COG0557	exoribonuclease II activity
CVS48_RS03230	COG1175	transmembrane transport
CVS48_RS03245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CVS48_RS03250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVS48_RS03260	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVS48_RS03265	COG3328	transposase activity
CVS48_RS03270	COG1126	abc transporter atp-binding protein
CVS48_RS03275	COG0765	amino acid transport
CVS48_RS03285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS03290	COG0436	Aminotransferase
CVS48_RS03295	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_RS03310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CVS48_RS03325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CVS48_RS03330	COG1678	Uncharacterized ACR, COG1678
CVS48_RS03345	COG0352	thiamine-phosphate diphosphorylase activity
CVS48_RS03350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CVS48_RS03355	COG0741	lytic transglycosylase activity
CVS48_RS03365	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS03370	COG1335	isochorismatase
CVS48_RS03375	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CVS48_RS03380	COG4638	Rieske (2fe-2S)
CVS48_RS03395	COG2207	Transcriptional regulator
CVS48_RS03420	COG1024	Enoyl-CoA hydratase
CVS48_RS03425	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS03495	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CVS48_RS03505	COG0494	nUDIX hydrolase
CVS48_RS03520	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CVS48_RS03525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_RS03540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS48_RS03555	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CVS48_RS03560	COG0237	dephospho-CoA kinase activity
CVS48_RS03565	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CVS48_RS03580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CVS48_RS03585	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CVS48_RS03595	COG0477	Major facilitator Superfamily
CVS48_RS03605	COG3328	transposase activity
CVS48_RS03615	COG1194	a g-specific adenine glycosylase
CVS48_RS03625	COG2226	methyltransferase
CVS48_RS03630	COG0246	Mannitol dehydrogenase
CVS48_RS03635	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_RS03640	COG1126	abc transporter atp-binding protein
CVS48_RS03645	COG0765	amino acid transport
CVS48_RS03650	COG0765	amino acid transport
CVS48_RS03655	COG1063	alcohol dehydrogenase
CVS48_RS03665	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CVS48_RS03670	COG2186	Transcriptional regulator
CVS48_RS03685	COG4771	TonB-dependent receptor
CVS48_RS03690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVS48_RS03695	COG2022	thiamine diphosphate biosynthetic process
CVS48_RS03700	COG0351	phosphomethylpyrimidine kinase
CVS48_RS03705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVS48_RS03715	COG3415	Transposase
CVS48_RS03715	COG2801	Transposase and inactivated derivatives
CVS48_RS03720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CVS48_RS03730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CVS48_RS03745	COG2226	methyltransferase
CVS48_RS03750	COG0745	RESPONSE REGULATOR receiver
CVS48_RS03765	COG0642	Histidine kinase
CVS48_RS03770	COG2132	Multicopper oxidase
CVS48_RS03785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS48_RS03790	COG3415	Transposase
CVS48_RS03790	COG2801	Transposase and inactivated derivatives
CVS48_RS03795	COG0583	DNA-binding transcription factor activity
CVS48_RS03805	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CVS48_RS03810	COG1984	allophanate hydrolase subunit 2
CVS48_RS03815	COG1802	Transcriptional regulator
CVS48_RS03820	COG2860	membrane
CVS48_RS03830	COG2223	nitrite transmembrane transporter activity
CVS48_RS03835	COG2813	Specifically methylates the guanine in position
CVS48_RS03835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CVS48_RS03840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CVS48_RS03845	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CVS48_RS03855	COG2197	response regulator
CVS48_RS03870	COG2918	glutathione biosynthetic process
CVS48_RS03890	COG0583	DNA-binding transcription factor activity
CVS48_RS03895	COG0657	acetylesterase activity
CVS48_RS03900	COG1802	Transcriptional regulator
CVS48_RS03930	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS48_RS03955	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_RS03970	COG1309	transcriptional regulator
CVS48_RS03980	COG1024	Enoyl-CoA hydratase
CVS48_RS03985	COG1024	Enoyl-CoA hydratase
CVS48_RS03990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CVS48_RS04000	COG0747	negative chemotaxis
CVS48_RS04005	COG2988	succinylglutamate desuccinylase activity
CVS48_RS04010	COG0601	transmembrane transport
CVS48_RS04020	COG0444	Belongs to the ABC transporter superfamily
CVS48_RS04025	COG4608	Belongs to the ABC transporter superfamily
CVS48_RS04035	COG2195	Cleaves the N-terminal amino acid of tripeptides
CVS48_RS04040	COG2171	N-acyltransferase activity
CVS48_RS04050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVS48_RS04065	COG0210	DNA helicase
CVS48_RS04070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CVS48_RS04075	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CVS48_RS04085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CVS48_RS04090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CVS48_RS04095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CVS48_RS04100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CVS48_RS04105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CVS48_RS04120	COG0356	it plays a direct role in the translocation of protons across the membrane
CVS48_RS04135	COG1024	Enoyl-CoA hydratase
CVS48_RS04140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS48_RS04150	COG3188	usher protein
CVS48_RS04155	COG3121	Chaperone
CVS48_RS04160	COG3539	Fimbrial protein
CVS48_RS04170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CVS48_RS04195	COG0037	tRNA processing
CVS48_RS04200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS48_RS04205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS48_RS04210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_RS04215	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CVS48_RS04220	COG2967	ApaG domain
CVS48_RS04225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CVS48_RS04230	COG0546	phosphoglycolate phosphatase activity
CVS48_RS04240	COG0512	Glutamine amidotransferase of anthranilate synthase
CVS48_RS04245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVS48_RS04250	COG0134	indole-3-glycerol-phosphate synthase activity
CVS48_RS04255	COG3284	Transcriptional regulator
CVS48_RS04260	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS04280	COG0583	DNA-binding transcription factor activity
CVS48_RS04290	COG1305	Transglutaminase-like
CVS48_RS04300	COG3276	selenocysteine insertion sequence binding
CVS48_RS04305	COG1921	L-seryl-tRNASec selenium transferase activity
CVS48_RS04310	COG3058	Necessary for formate dehydrogenase activity
CVS48_RS04315	COG2864	formate dehydrogenase
CVS48_RS04320	COG0437	4 iron, 4 sulfur cluster binding
CVS48_RS04325	COG0243	molybdopterin cofactor binding
CVS48_RS04325	COG3383	formate dehydrogenase (NAD+) activity
CVS48_RS04330	COG0243	molybdopterin cofactor binding
CVS48_RS04330	COG3383	formate dehydrogenase (NAD+) activity
CVS48_RS04340	COG1607	acyl-coa hydrolase
CVS48_RS04365	COG3064	Membrane
CVS48_RS04385	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS04390	COG3069	C4-dicarboxylate transmembrane transporter activity
CVS48_RS04400	COG1802	Transcriptional regulator
CVS48_RS04440	COG2814	Major facilitator Superfamily
CVS48_RS04445	COG0840	transmembrane signaling receptor activity
CVS48_RS04450	COG1228	amidohydrolase
CVS48_RS04465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CVS48_RS04470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CVS48_RS04480	COG2188	Transcriptional regulator
CVS48_RS04500	COG0297	glycogen (starch) synthase activity
CVS48_RS04515	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVS48_RS04525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CVS48_RS04530	COG5001	Diguanylate cyclase
CVS48_RS04540	COG2423	ornithine cyclodeaminase activity
CVS48_RS04545	COG1522	sequence-specific DNA binding
CVS48_RS04580	COG4944	Protein of unknown function (DUF1109)
CVS48_RS04585	COG1595	DNA-templated transcription, initiation
CVS48_RS04590	COG3300	MHYT domain
CVS48_RS04590	COG5001	Diguanylate cyclase
CVS48_RS04595	COG0583	DNA-binding transcription factor activity
CVS48_RS04600	COG2814	Major facilitator Superfamily
CVS48_RS04610	COG0583	DNA-binding transcription factor activity
CVS48_RS04615	COG0656	L-ascorbic acid biosynthetic process
CVS48_RS04620	COG0583	DNA-binding transcription factor activity
CVS48_RS04625	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS04630	COG0154	amidase activity
CVS48_RS04635	COG0243	molybdopterin cofactor binding
CVS48_RS04655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CVS48_RS04665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS48_RS04690	COG0583	DNA-binding transcription factor activity
CVS48_RS04695	COG3866	Pectate lyase
CVS48_RS04725	COG0438	transferase activity, transferring glycosyl groups
CVS48_RS04730	COG0457	Tetratricopeptide repeat
CVS48_RS04760	COG0251	oxidation-reduction process
CVS48_RS04765	COG0583	DNA-binding transcription factor activity
CVS48_RS04820	COG2205	protein histidine kinase activity
CVS48_RS04820	COG0784	Response regulator, receiver
CVS48_RS04820	COG2198	Histidine kinase
CVS48_RS04820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS04825	COG3437	response regulator, receiver
CVS48_RS04840	COG1074	ATP-dependent DNA helicase activity
CVS48_RS04900	COG2814	Major facilitator Superfamily
CVS48_RS04905	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CVS48_RS04925	COG1999	signal sequence binding
CVS48_RS04935	COG1612	heme a metabolic process
CVS48_RS04970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVS48_RS04990	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CVS48_RS04995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CVS48_RS05015	COG0067	glutamate synthase
CVS48_RS05015	COG0070	glutamate synthase
CVS48_RS05015	COG0069	glutamate synthase activity
CVS48_RS05030	COG0583	DNA-binding transcription factor activity
CVS48_RS05035	COG0477	Major facilitator Superfamily
CVS48_RS05045	COG2070	2-Nitropropane dioxygenase
CVS48_RS05050	COG1127	ABC transporter
CVS48_RS05055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CVS48_RS05060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CVS48_RS05065	COG2853	Lipoprotein
CVS48_RS05075	COG1131	(ABC) transporter
CVS48_RS05080	COG0842	Transport permease protein
CVS48_RS05085	COG5007	Belongs to the BolA IbaG family
CVS48_RS05090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CVS48_RS05095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CVS48_RS05100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CVS48_RS05105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVS48_RS05110	COG0131	Imidazoleglycerol-phosphate dehydratase
CVS48_RS05115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CVS48_RS05120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CVS48_RS05125	COG0107	imidazoleglycerol-phosphate synthase activity
CVS48_RS05130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CVS48_RS05135	COG0140	phosphoribosyl-ATP diphosphatase activity
CVS48_RS05140	COG0537	adenosine 5'-monophosphoramidase activity
CVS48_RS05145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS48_RS05150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS48_RS05170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CVS48_RS05175	COG1970	mechanosensitive ion channel activity
CVS48_RS05180	COG0723	plastoquinol--plastocyanin reductase activity
CVS48_RS05185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CVS48_RS05190	COG2857	Cytochrome c1
CVS48_RS05195	COG0625	glutathione transferase activity
CVS48_RS05200	COG2969	positive regulation of protein catabolic process
CVS48_RS05205	COG3718	enzyme involved in inositol metabolism
CVS48_RS05215	COG3962	Belongs to the TPP enzyme family
CVS48_RS05230	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVS48_RS05240	COG1737	Transcriptional regulator
CVS48_RS05245	COG0673	inositol 2-dehydrogenase activity
CVS48_RS05250	COG0673	inositol 2-dehydrogenase activity
CVS48_RS05280	COG0154	amidase activity
CVS48_RS05285	COG1414	Transcriptional regulator
CVS48_RS05295	COG0583	DNA-binding transcription factor activity
CVS48_RS05310	COG0697	spore germination
CVS48_RS05315	COG2207	Transcriptional regulator
CVS48_RS05315	COG3708	Transcriptional regulator
CVS48_RS05325	COG1160	GTP binding
CVS48_RS05330	COG0747	negative chemotaxis
CVS48_RS05335	COG0601	transmembrane transport
CVS48_RS05340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS05355	COG5339	Protein conserved in bacteria
CVS48_RS05360	COG0513	Belongs to the DEAD box helicase family
CVS48_RS05365	COG1280	lysine exporter protein (LysE YggA)
CVS48_RS05370	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CVS48_RS05390	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CVS48_RS05400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_RS05410	COG1609	Transcriptional regulator
CVS48_RS05415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CVS48_RS05420	COG3842	ATPase activity
CVS48_RS05425	COG1653	transport
CVS48_RS05430	COG1175	transmembrane transport
CVS48_RS05435	COG0395	ABC-type sugar transport system, permease component
CVS48_RS05460	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS48_RS05480	COG0778	Nitroreductase
CVS48_RS05485	COG1280	lysine exporter protein (LysE YggA)
CVS48_RS05505	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS05510	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CVS48_RS05515	COG0183	Belongs to the thiolase family
CVS48_RS05520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVS48_RS05535	COG0693	protein deglycase activity
CVS48_RS05560	COG3852	Histidine kinase
CVS48_RS05585	COG0346	lactoylglutathione lyase activity
CVS48_RS05595	COG0668	transmembrane transport
CVS48_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS05600	COG0604	alcohol dehydrogenase
CVS48_RS05600	COG3321	synthase
CVS48_RS05615	COG0583	DNA-binding transcription factor activity
CVS48_RS05630	COG0300	oxidoreductase activity
CVS48_RS05635	COG2207	Transcriptional regulator
CVS48_RS05660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVS48_RS05670	COG0477	Major facilitator Superfamily
CVS48_RS05675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS05680	COG0765	amino acid transport
CVS48_RS05685	COG0765	amino acid transport
CVS48_RS05700	COG2358	TRAP transporter, solute receptor (TAXI family
CVS48_RS05710	COG2922	Belongs to the Smg family
CVS48_RS05715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS48_RS05725	COG0551	DNA topoisomerase type I activity
CVS48_RS05725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CVS48_RS05735	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CVS48_RS05740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_RS05745	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS05750	COG0028	Belongs to the TPP enzyme family
CVS48_RS05755	COG1522	sequence-specific DNA binding
CVS48_RS05760	COG3781	membrane
CVS48_RS05790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CVS48_RS05800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CVS48_RS05815	COG3845	ABC transporter
CVS48_RS05820	COG4603	Belongs to the binding-protein-dependent transport system permease family
CVS48_RS05830	COG0402	S-adenosylhomocysteine deaminase activity
CVS48_RS05860	COG1177	transmembrane transport
CVS48_RS05865	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_RS05870	COG3842	ATPase activity
CVS48_RS05880	COG2188	Transcriptional regulator
CVS48_RS05895	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS05935	COG1177	transmembrane transport
CVS48_RS05940	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_RS05945	COG3842	ATPase activity
CVS48_RS05980	COG1126	abc transporter atp-binding protein
CVS48_RS05985	COG0765	amino acid transport
CVS48_RS05990	COG0765	amino acid transport
CVS48_RS06000	COG0583	DNA-binding transcription factor activity
CVS48_RS06030	COG0592	DNA-directed DNA polymerase activity
CVS48_RS06035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CVS48_RS06040	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CVS48_RS06045	COG0594	ribonuclease P activity
CVS48_RS06050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CVS48_RS06060	COG0753	catalase activity
CVS48_RS06065	COG1473	amidohydrolase
CVS48_RS06070	COG4608	Belongs to the ABC transporter superfamily
CVS48_RS06075	COG0444	Belongs to the ABC transporter superfamily
CVS48_RS06080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS06095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CVS48_RS06100	COG0456	acetyltransferase
CVS48_RS06100	COG0454	-acetyltransferase
CVS48_RS06105	COG0038	chloride channel
CVS48_RS06115	COG3850	Histidine kinase
CVS48_RS06115	COG5002	protein histidine kinase activity
CVS48_RS06135	COG0436	Aminotransferase
CVS48_RS06140	COG3180	Ammonia monooxygenase
CVS48_RS06145	COG1278	Cold shock
CVS48_RS06150	COG0445	tRNA wobble uridine modification
CVS48_RS06155	COG0357	Ribosomal RNA small subunit methyltransferase G
CVS48_RS06160	COG1192	Involved in chromosome partitioning
CVS48_RS06170	COG1475	DNA binding
CVS48_RS06175	COG0252	asparaginase activity
CVS48_RS06180	COG0583	DNA-binding transcription factor activity
CVS48_RS06235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVS48_RS06255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CVS48_RS06260	COG0081	regulation of translation
CVS48_RS06265	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CVS48_RS06270	COG0222	ribosome binding
CVS48_RS06275	COG0085	RNA polymerase activity
CVS48_RS06280	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CVS48_RS06315	COG0745	RESPONSE REGULATOR receiver
CVS48_RS06320	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CVS48_RS06325	COG0049	tRNA binding
CVS48_RS06330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CVS48_RS06335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVS48_RS06340	COG0051	transcription antitermination factor activity, RNA binding
CVS48_RS06345	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CVS48_RS06350	COG1414	Transcriptional regulator
CVS48_RS06360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_RS06375	COG1116	anion transmembrane transporter activity
CVS48_RS06380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_RS06385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CVS48_RS06395	COG0089	rRNA binding
CVS48_RS06400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CVS48_RS06405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CVS48_RS06410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CVS48_RS06415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CVS48_RS06420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CVS48_RS06425	COG0255	Belongs to the universal ribosomal protein uL29 family
CVS48_RS06430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CVS48_RS06450	COG4177	L-phenylalanine transmembrane transporter activity
CVS48_RS06460	COG0411	ABC transporter
CVS48_RS06475	COG2207	Transcriptional regulator
CVS48_RS06490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CVS48_RS06495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CVS48_RS06500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CVS48_RS06505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CVS48_RS06510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CVS48_RS06515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CVS48_RS06520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CVS48_RS06525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CVS48_RS06530	COG1841	ribosomal large subunit assembly
CVS48_RS06535	COG0200	Binds to the 23S rRNA
CVS48_RS06540	COG0201	protein transport
CVS48_RS06545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CVS48_RS06550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CVS48_RS06555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CVS48_RS06560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CVS48_RS06565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CVS48_RS06570	COG0202	RNA polymerase activity
CVS48_RS06575	COG0203	ribosomal protein L17
CVS48_RS06585	COG1324	tolerance protein
CVS48_RS06590	COG4232	protein-disulfide reductase activity
CVS48_RS06605	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CVS48_RS06615	COG1333	cytochrome c biogenesis protein
CVS48_RS06620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS48_RS06740	COG0019	diaminopimelate decarboxylase activity
CVS48_RS06750	COG1965	Belongs to the frataxin family
CVS48_RS06760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CVS48_RS06765	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CVS48_RS06770	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CVS48_RS06785	COG2814	Major facilitator Superfamily
CVS48_RS06795	COG3210	domain, Protein
CVS48_RS06815	COG0583	DNA-binding transcription factor activity
CVS48_RS06820	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_RS06825	COG4774	siderophore transport
CVS48_RS06830	COG2207	Transcriptional regulator
CVS48_RS06835	COG2226	methyltransferase
CVS48_RS06870	COG2186	Transcriptional regulator
CVS48_RS06895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_RS06900	COG1956	GAF domain-containing protein
CVS48_RS06905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_RS06920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVS48_RS06945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CVS48_RS06950	COG3568	Endonuclease Exonuclease Phosphatase
CVS48_RS06955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS48_RS06965	COG0477	Major facilitator Superfamily
CVS48_RS06970	COG0756	dUTP diphosphatase activity
CVS48_RS06995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS48_RS07030	COG1134	teichoic acid transport
CVS48_RS07045	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CVS48_RS07055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CVS48_RS07065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVS48_RS07075	COG2089	acid synthase
CVS48_RS07080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CVS48_RS07085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CVS48_RS07090	COG1088	dTDP-glucose 4,6-dehydratase activity
CVS48_RS07110	COG0438	transferase activity, transferring glycosyl groups
CVS48_RS07115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CVS48_RS07120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CVS48_RS07140	COG0673	inositol 2-dehydrogenase activity
CVS48_RS07145	COG0859	PFAM glycosyl transferase family 9
CVS48_RS07160	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CVS48_RS07170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CVS48_RS07195	COG1686	Belongs to the peptidase S11 family
CVS48_RS07205	COG2921	Belongs to the UPF0250 family
CVS48_RS07210	COG0321	lipoyl(octanoyl) transferase activity
CVS48_RS07220	COG1609	Transcriptional regulator
CVS48_RS07225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CVS48_RS07230	COG2096	Adenosyltransferase
CVS48_RS07240	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CVS48_RS07255	COG0523	cobalamin synthesis protein
CVS48_RS07260	COG0735	belongs to the Fur family
CVS48_RS07285	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CVS48_RS07290	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CVS48_RS07300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CVS48_RS07305	COG1560	Kdo2-lipid A biosynthetic process
CVS48_RS07315	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CVS48_RS07320	COG0154	amidase activity
CVS48_RS07325	COG0477	Major facilitator Superfamily
CVS48_RS07340	COG1079	Belongs to the binding-protein-dependent transport system permease family
CVS48_RS07360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CVS48_RS07375	COG0583	DNA-binding transcription factor activity
CVS48_RS07380	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS07390	COG0066	3-isopropylmalate dehydratase activity
CVS48_RS07395	COG0596	Alpha beta hydrolase
CVS48_RS07405	COG0438	transferase activity, transferring glycosyl groups
CVS48_RS07410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CVS48_RS07415	COG1950	PFAM Membrane protein of
CVS48_RS07420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CVS48_RS07435	COG1305	Transglutaminase-like
CVS48_RS07445	COG2308	Evidence 4 Homologs of previously reported genes of
CVS48_RS07470	COG0513	Belongs to the DEAD box helicase family
CVS48_RS07475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CVS48_RS07515	COG0640	Transcriptional regulator
CVS48_RS07570	COG1846	Transcriptional regulator
CVS48_RS07575	COG1764	response to oxidative stress
CVS48_RS07585	COG0583	DNA-binding transcription factor activity
CVS48_RS07595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CVS48_RS07600	COG0708	Exodeoxyribonuclease III
CVS48_RS07605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CVS48_RS07615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CVS48_RS07620	COG0154	amidase activity
CVS48_RS07625	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CVS48_RS07630	COG1077	Cell shape determining protein MreB Mrl
CVS48_RS07635	COG1792	Involved in formation and maintenance of cell shape
CVS48_RS07645	COG0768	penicillin binding
CVS48_RS07650	COG0772	Belongs to the SEDS family
CVS48_RS07655	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CVS48_RS07660	COG0471	metal ion transport
CVS48_RS07665	COG1309	transcriptional regulator
CVS48_RS07675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVS48_RS07680	COG1464	Belongs to the NlpA lipoprotein family
CVS48_RS07685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS48_RS07690	COG2823	Periplasmic or secreted lipoprotein
CVS48_RS07695	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CVS48_RS07700	COG0792	nuclease activity
CVS48_RS07710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVS48_RS07720	COG1660	Displays ATPase and GTPase activities
CVS48_RS07735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_RS07740	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CVS48_RS07750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CVS48_RS07755	COG1137	ATPase activity
CVS48_RS07770	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CVS48_RS07780	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CVS48_RS07790	COG1271	oxidase subunit
CVS48_RS07795	COG1294	oxidase, subunit
CVS48_RS07805	COG4988	ABC transporter
CVS48_RS07810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CVS48_RS07830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_RS07835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS48_RS07840	COG1238	metal cluster binding
CVS48_RS07850	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS07855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CVS48_RS07860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_RS07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS07880	COG0758	DNA mediated transformation
CVS48_RS07885	COG0242	peptide deformylase activity
CVS48_RS07890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CVS48_RS07905	COG0546	phosphoglycolate phosphatase activity
CVS48_RS07925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVS48_RS07930	COG1280	lysine exporter protein (LysE YggA)
CVS48_RS07935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS48_RS07935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS48_RS07945	COG5000	phosphorelay sensor kinase activity
CVS48_RS07950	COG2204	response regulator
CVS48_RS07955	COG0569	domain protein
CVS48_RS07960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CVS48_RS07965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CVS48_RS07970	COG2226	methyltransferase
CVS48_RS07980	COG1040	competence protein
CVS48_RS07985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CVS48_RS07990	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS08000	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CVS48_RS08005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CVS48_RS08010	COG1054	Belongs to the UPF0176 family
CVS48_RS08015	COG0588	phosphoglycerate mutase activity
CVS48_RS08020	COG4942	peptidase
CVS48_RS08025	COG0793	Belongs to the peptidase S41A family
CVS48_RS08030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CVS48_RS08040	COG2186	Transcriptional regulator
CVS48_RS08050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CVS48_RS08055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS48_RS08070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CVS48_RS08075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CVS48_RS08080	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CVS48_RS08085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CVS48_RS08090	COG1414	Transcriptional regulator
CVS48_RS08100	COG0142	geranyltranstransferase activity
CVS48_RS08110	COG0489	protein tyrosine kinase activity
CVS48_RS08180	COG4974	Belongs to the 'phage' integrase family
CVS48_RS08200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS48_RS08240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_RS08275	COG0463	Glycosyl transferase, family 2
CVS48_RS08280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CVS48_RS08330	COG3133	Outer membrane lipoprotein
CVS48_RS08375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS48_RS08400	COG2948	multi-organism process
CVS48_RS08435	COG3451	type IV secretory pathway VirB4
CVS48_RS08580	COG0659	secondary active sulfate transmembrane transporter activity
CVS48_RS08585	COG2801	Transposase and inactivated derivatives
CVS48_RS08585	COG3415	Transposase
CVS48_RS08595	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CVS48_RS08615	COG1024	Enoyl-CoA hydratase
CVS48_RS08625	COG1309	transcriptional regulator
CVS48_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS08645	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS08650	COG0183	Belongs to the thiolase family
CVS48_RS08695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CVS48_RS08730	COG1073	alpha beta
CVS48_RS08730	COG2226	methyltransferase
CVS48_RS08760	COG0683	leucine binding
CVS48_RS08765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS48_RS08770	COG2084	Dehydrogenase
CVS48_RS08785	COG2814	Major facilitator Superfamily
CVS48_RS08790	COG0235	Class ii aldolase
CVS48_RS08795	COG2271	Major facilitator Superfamily
CVS48_RS08800	COG3622	Belongs to the hyi family
CVS48_RS08805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS48_RS08810	COG2084	Dehydrogenase
CVS48_RS08815	COG3395	kinase activity
CVS48_RS08825	COG2186	Transcriptional regulator
CVS48_RS08845	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CVS48_RS08850	COG3842	ATPase activity
CVS48_RS08860	COG0402	S-adenosylhomocysteine deaminase activity
CVS48_RS08885	COG3077	Addiction module antitoxin, RelB DinJ family
CVS48_RS08900	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS08905	COG0022	dehydrogenase e1 component
CVS48_RS08920	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS48_RS08930	COG0583	DNA-binding transcription factor activity
CVS48_RS08965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS08970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_RS08975	COG3622	Belongs to the hyi family
CVS48_RS08985	COG5006	permease, DMT superfamily
CVS48_RS08995	COG1522	sequence-specific DNA binding
CVS48_RS09005	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CVS48_RS09015	COG0583	DNA-binding transcription factor activity
CVS48_RS09020	COG1473	amidohydrolase
CVS48_RS09025	COG3264	Mechanosensitive ion channel
CVS48_RS09025	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CVS48_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS09040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_RS09045	COG1116	anion transmembrane transporter activity
CVS48_RS09080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CVS48_RS09085	COG2890	protein-(glutamine-N5) methyltransferase activity
CVS48_RS09090	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CVS48_RS09105	COG1464	Belongs to the NlpA lipoprotein family
CVS48_RS09110	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS09120	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS09145	COG0583	DNA-binding transcription factor activity
CVS48_RS09160	COG0625	glutathione transferase activity
CVS48_RS09165	COG0288	reversible hydration of carbon dioxide
CVS48_RS09185	COG0596	Alpha beta hydrolase
CVS48_RS09195	COG4829	muconolactone delta-isomerase
CVS48_RS09200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CVS48_RS09210	COG1414	Transcriptional regulator
CVS48_RS09215	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS09220	COG2031	fatty acid transporter
CVS48_RS09225	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_RS09230	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CVS48_RS09235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CVS48_RS09250	COG0583	DNA-binding transcription factor activity
CVS48_RS09255	COG0129	dihydroxy-acid dehydratase activity
CVS48_RS09260	COG0583	DNA-binding transcription factor activity
CVS48_RS09265	COG2801	Transposase and inactivated derivatives
CVS48_RS09265	COG3415	Transposase
CVS48_RS09270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS48_RS09275	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS48_RS09285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CVS48_RS09290	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS09295	COG0410	ABC transporter
CVS48_RS09325	COG2186	Transcriptional regulator
CVS48_RS09335	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CVS48_RS09350	COG2177	Part of the ABC transporter FtsEX involved in
CVS48_RS09355	COG2884	Cell division ATP-binding protein ftsE
CVS48_RS09360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS09365	COG4597	amino acid ABC transporter
CVS48_RS09370	COG0765	amino acid transport
CVS48_RS09375	COG1126	abc transporter atp-binding protein
CVS48_RS09390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_RS09395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS48_RS09405	COG0077	Prephenate dehydratase
CVS48_RS09405	COG1605	Chorismate mutase
CVS48_RS09410	COG0625	glutathione transferase activity
CVS48_RS09455	COG0583	DNA-binding transcription factor activity
CVS48_RS09460	COG0628	permease
CVS48_RS09475	COG3328	transposase activity
CVS48_RS09480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_RS09485	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_RS09490	COG3842	ATPase activity
CVS48_RS09500	COG0277	FAD linked oxidase domain protein
CVS48_RS09510	COG0477	Major facilitator Superfamily
CVS48_RS09520	COG1695	Transcriptional regulator
CVS48_RS09530	COG0583	DNA-binding transcription factor activity
CVS48_RS09580	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS09590	COG3246	L-lysine catabolic process to acetate
CVS48_RS09595	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS48_RS09600	COG0210	DNA helicase
CVS48_RS09605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS09615	COG0583	DNA-binding transcription factor activity
CVS48_RS09620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CVS48_RS09625	COG0477	Major facilitator Superfamily
CVS48_RS09635	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVS48_RS09635	COG2010	Cytochrome c
CVS48_RS09640	COG1335	isochorismatase
CVS48_RS09645	COG2309	aminopeptidase activity
CVS48_RS09650	COG0596	Alpha beta hydrolase
CVS48_RS09655	COG3473	Maleate cis-trans isomerase
CVS48_RS09665	COG2080	2 iron, 2 sulfur cluster binding
CVS48_RS09670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVS48_RS09670	COG2010	Cytochrome c
CVS48_RS09675	COG0477	Major facilitator Superfamily
CVS48_RS09680	COG1846	Transcriptional regulator
CVS48_RS09735	COG2233	PERMEase
CVS48_RS09740	COG0326	Molecular chaperone. Has ATPase activity
CVS48_RS09745	COG1396	sequence-specific DNA binding
CVS48_RS09760	COG0604	alcohol dehydrogenase
CVS48_RS09770	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS09790	COG2814	Major facilitator Superfamily
CVS48_RS09800	COG2271	Major facilitator Superfamily
CVS48_RS09805	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_RS09810	COG0800	Aldolase
CVS48_RS09820	COG1414	Transcriptional regulator
CVS48_RS09825	COG0625	glutathione transferase activity
CVS48_RS09840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS48_RS09845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CVS48_RS09850	COG1652	LysM domain
CVS48_RS09870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CVS48_RS09880	COG1802	Transcriptional regulator
CVS48_RS09885	COG3938	Belongs to the proline racemase family
CVS48_RS09890	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS09895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_RS09900	COG3938	Belongs to the proline racemase family
CVS48_RS09905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_RS09915	COG0765	amino acid transport
CVS48_RS09920	COG1126	abc transporter atp-binding protein
CVS48_RS09940	COG3550	peptidyl-serine autophosphorylation
CVS48_RS09975	COG3246	L-lysine catabolic process to acetate
CVS48_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS09985	COG2072	flavoprotein involved in K transport
CVS48_RS09990	COG3842	ATPase activity
CVS48_RS10010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS48_RS10015	COG1177	transmembrane transport
CVS48_RS10020	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_RS10040	COG0583	DNA-binding transcription factor activity
CVS48_RS10050	COG0165	Argininosuccinate lyase
CVS48_RS10060	COG2814	Major facilitator Superfamily
CVS48_RS10065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_RS10070	COG3152	Membrane
CVS48_RS10080	COG2188	Transcriptional regulator
CVS48_RS10090	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS10100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS10110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS48_RS10140	COG2828	Protein conserved in bacteria
CVS48_RS10160	COG3284	Transcriptional regulator
CVS48_RS10170	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS10175	COG2267	carboxylic ester hydrolase activity
CVS48_RS10185	COG0583	DNA-binding transcription factor activity
CVS48_RS10190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS48_RS10195	COG1131	(ABC) transporter
CVS48_RS10215	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_RS10285	COG3328	transposase activity
CVS48_RS10370	COG0625	glutathione transferase activity
CVS48_RS10380	COG3976	FMN-binding domain protein
CVS48_RS10380	COG1053	succinate dehydrogenase
CVS48_RS10380	COG0431	NADPH-dependent FMN reductase
CVS48_RS10400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_RS10410	COG1294	oxidase, subunit
CVS48_RS10415	COG1271	oxidase subunit
CVS48_RS10425	COG0410	ABC transporter
CVS48_RS10440	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS10460	COG2200	EAL domain
CVS48_RS10465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CVS48_RS10470	COG0745	RESPONSE REGULATOR receiver
CVS48_RS10495	COG1054	Belongs to the UPF0176 family
CVS48_RS10510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS48_RS10510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS48_RS10520	COG0489	protein tyrosine kinase activity
CVS48_RS10535	COG0717	Belongs to the dCTP deaminase family
CVS48_RS10545	COG5001	Diguanylate cyclase
CVS48_RS10545	COG4251	negative regulation of phosphorylation
CVS48_RS10545	COG2203	Gaf domain
CVS48_RS10545	COG3706	GGDEF domain
CVS48_RS10565	COG2081	HI0933 family
CVS48_RS10580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CVS48_RS10585	COG0509	glycine decarboxylation via glycine cleavage system
CVS48_RS10590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVS48_RS10590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVS48_RS10595	COG5339	Protein conserved in bacteria
CVS48_RS10605	COG0154	amidase activity
CVS48_RS10610	COG4172	Belongs to the ABC transporter superfamily
CVS48_RS10615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS10620	COG0601	transmembrane transport
CVS48_RS10640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVS48_RS10645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_RS10665	COG1765	OsmC-like protein
CVS48_RS10670	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CVS48_RS10675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS48_RS10680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CVS48_RS10705	COG0438	transferase activity, transferring glycosyl groups
CVS48_RS10710	COG0438	transferase activity, transferring glycosyl groups
CVS48_RS10715	COG0438	transferase activity, transferring glycosyl groups
CVS48_RS10720	COG0166	Belongs to the GPI family
CVS48_RS10735	COG0277	FAD linked oxidase domain protein
CVS48_RS10740	COG0745	RESPONSE REGULATOR receiver
CVS48_RS10745	COG2205	protein histidine kinase activity
CVS48_RS10755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CVS48_RS10755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_RS10765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_RS10775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS48_RS10780	COG2186	Transcriptional regulator
CVS48_RS10785	COG1368	sulfuric ester hydrolase activity
CVS48_RS10790	COG2801	Transposase and inactivated derivatives
CVS48_RS10790	COG3415	Transposase
CVS48_RS10800	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CVS48_RS10815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_RS10825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CVS48_RS10840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CVS48_RS10845	COG1309	transcriptional regulator
CVS48_RS10850	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS10855	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CVS48_RS10860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CVS48_RS10880	COG0193	aminoacyl-tRNA hydrolase activity
CVS48_RS10890	COG0012	GTP binding
CVS48_RS10895	COG4804	nuclease activity
CVS48_RS10905	COG2801	Transposase and inactivated derivatives
CVS48_RS10910	COG2814	Major facilitator Superfamily
CVS48_RS10925	COG0583	DNA-binding transcription factor activity
CVS48_RS10940	COG2814	Major facilitator Superfamily
CVS48_RS10955	COG3135	benzoate transporter
CVS48_RS10960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS48_RS10965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CVS48_RS10970	COG0742	ribosomal rna small subunit methyltransferase
CVS48_RS10995	COG3639	organic phosphonate transmembrane transporter activity
CVS48_RS11000	COG3639	organic phosphonate transmembrane transporter activity
CVS48_RS11005	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CVS48_RS11030	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CVS48_RS11035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS48_RS11050	COG1546	Belongs to the CinA family
CVS48_RS11055	COG0284	orotidine-5'-phosphate decarboxylase activity
CVS48_RS11060	COG1252	NADH dehydrogenase
CVS48_RS11065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CVS48_RS11075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_RS11085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS11095	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS48_RS11100	COG2721	sulfolactate sulfo-lyase activity
CVS48_RS11105	COG0246	Mannitol dehydrogenase
CVS48_RS11115	COG0410	ABC transporter
CVS48_RS11120	COG1137	ATPase activity
CVS48_RS11130	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_RS11145	COG1917	Cupin 2, conserved barrel domain protein
CVS48_RS11160	COG0459	protein refolding
CVS48_RS11165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CVS48_RS11170	COG1024	Enoyl-CoA hydratase
CVS48_RS11175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS11185	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS11190	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS48_RS11190	COG1042	CoA-binding domain protein
CVS48_RS11190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS48_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS11210	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS11215	COG2030	dehydratase
CVS48_RS11225	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS11265	COG0583	DNA-binding transcription factor activity
CVS48_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS11295	COG3706	GGDEF domain
CVS48_RS11295	COG4251	negative regulation of phosphorylation
CVS48_RS11295	COG5001	Diguanylate cyclase
CVS48_RS11295	COG2203	Gaf domain
CVS48_RS11325	COG3321	synthase
CVS48_RS11325	COG0604	alcohol dehydrogenase
CVS48_RS11370	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS11375	COG1024	Enoyl-CoA hydratase
CVS48_RS11400	COG0745	RESPONSE REGULATOR receiver
CVS48_RS11405	COG2205	protein histidine kinase activity
CVS48_RS11420	COG0438	transferase activity, transferring glycosyl groups
CVS48_RS11445	COG2207	Transcriptional regulator
CVS48_RS11445	COG4753	response regulator
CVS48_RS11460	COG0596	Alpha beta hydrolase
CVS48_RS11470	COG0477	Major facilitator Superfamily
CVS48_RS11500	COG0745	RESPONSE REGULATOR receiver
CVS48_RS11505	COG2205	protein histidine kinase activity
CVS48_RS11505	COG2198	Histidine kinase
CVS48_RS11505	COG0784	Response regulator, receiver
CVS48_RS11505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS11515	COG0277	FAD linked oxidase domain protein
CVS48_RS11520	COG3119	arylsulfatase activity
CVS48_RS11530	COG0583	DNA-binding transcription factor activity
CVS48_RS11545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS48_RS11580	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS11590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS48_RS11595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_RS11600	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS11645	COG1414	Transcriptional regulator
CVS48_RS11665	COG0583	DNA-binding transcription factor activity
CVS48_RS11690	COG1595	DNA-templated transcription, initiation
CVS48_RS11695	COG3712	iron ion homeostasis
CVS48_RS11735	COG1764	response to oxidative stress
CVS48_RS11740	COG0583	DNA-binding transcription factor activity
CVS48_RS11750	COG1595	DNA-templated transcription, initiation
CVS48_RS11765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS48_RS11770	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS11780	COG0387	Pfam Sodium calcium exchanger
CVS48_RS11795	COG3135	benzoate transporter
CVS48_RS11805	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CVS48_RS11805	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CVS48_RS11820	COG2188	Transcriptional regulator
CVS48_RS11825	COG1280	lysine exporter protein (LysE YggA)
CVS48_RS11835	COG3387	PFAM Glycoside hydrolase 15-related
CVS48_RS11845	COG0745	RESPONSE REGULATOR receiver
CVS48_RS11860	COG3119	arylsulfatase activity
CVS48_RS11890	COG2353	YceI-like domain
CVS48_RS11910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS48_RS11930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_RS11945	COG0642	Histidine kinase
CVS48_RS11960	COG2837	iron assimilation
CVS48_RS11990	COG0667	Aldo Keto reductase
CVS48_RS12005	COG0519	Catalyzes the synthesis of GMP from XMP
CVS48_RS12030	COG2197	response regulator
CVS48_RS12035	COG0784	Response regulator, receiver
CVS48_RS12035	COG2205	protein histidine kinase activity
CVS48_RS12040	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CVS48_RS12045	COG0784	Response regulator, receiver
CVS48_RS12045	COG2205	protein histidine kinase activity
CVS48_RS12070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_RS12080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CVS48_RS12090	COG3346	SURF1 family
CVS48_RS12095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CVS48_RS12100	COG1845	cytochrome c oxidase, subunit III
CVS48_RS12105	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVS48_RS12110	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CVS48_RS12115	COG0477	Major facilitator Superfamily
CVS48_RS12150	COG0583	DNA-binding transcription factor activity
CVS48_RS12155	COG0861	Integral membrane protein TerC family
CVS48_RS12160	COG4106	trans-aconitate 2-methyltransferase activity
CVS48_RS12165	COG2207	Transcriptional regulator
CVS48_RS12170	COG2807	transmembrane transport
CVS48_RS12185	COG0330	HflC and HflK could
CVS48_RS12205	COG4773	Receptor
CVS48_RS12220	COG3712	iron ion homeostasis
CVS48_RS12235	COG1595	DNA-templated transcription, initiation
CVS48_RS12240	COG3712	iron ion homeostasis
CVS48_RS12250	COG2706	6-phosphogluconolactonase activity
CVS48_RS12260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CVS48_RS12275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS48_RS12280	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS12285	COG1285	pathogenesis
CVS48_RS12290	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS12320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS48_RS12325	COG1396	sequence-specific DNA binding
CVS48_RS12345	COG0583	DNA-binding transcription factor activity
CVS48_RS12350	COG0300	oxidoreductase activity
CVS48_RS12360	COG0583	DNA-binding transcription factor activity
CVS48_RS12375	COG0697	spore germination
CVS48_RS12390	COG0281	malic enzyme
CVS48_RS12390	COG0280	phosphate acetyltransferase
CVS48_RS12395	COG0583	DNA-binding transcription factor activity
CVS48_RS12400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS48_RS12420	COG2900	Belongs to the SlyX family
CVS48_RS12425	COG4772	TonB-dependent receptor
CVS48_RS12440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CVS48_RS12445	COG1845	cytochrome c oxidase, subunit III
CVS48_RS12450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVS48_RS12460	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CVS48_RS12475	COG1999	signal sequence binding
CVS48_RS12490	COG1126	abc transporter atp-binding protein
CVS48_RS12495	COG0765	amino acid transport
CVS48_RS12500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS12505	COG3191	aminopeptidase activity
CVS48_RS12510	COG1272	protein, Hemolysin III
CVS48_RS12525	COG1113	amino acid transport
CVS48_RS12550	COG1595	DNA-templated transcription, initiation
CVS48_RS12555	COG3712	iron ion homeostasis
CVS48_RS12565	COG3720	iron ion transport
CVS48_RS12570	COG4558	Periplasmic binding protein
CVS48_RS12575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS48_RS12580	COG1120	ATPase activity
CVS48_RS12585	COG1666	GTP binding
CVS48_RS12595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CVS48_RS12615	COG0671	phosphoesterase, PA-phosphatase related
CVS48_RS12675	COG3328	transposase activity
CVS48_RS12700	COG0583	DNA-binding transcription factor activity
CVS48_RS12705	COG2828	Protein conserved in bacteria
CVS48_RS12715	COG1943	Transposase
CVS48_RS12730	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS12775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CVS48_RS12780	COG0583	DNA-binding transcription factor activity
CVS48_RS12805	COG2223	nitrite transmembrane transporter activity
CVS48_RS12815	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CVS48_RS12820	COG3383	formate dehydrogenase (NAD+) activity
CVS48_RS12840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CVS48_RS12845	COG0746	molybdenum cofactor guanylyltransferase activity
CVS48_RS12850	COG0303	'Molybdopterin
CVS48_RS12855	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVS48_RS12860	COG0314	molybdopterin synthase activity
CVS48_RS12870	COG0315	cyclic pyranopterin monophosphate synthase activity
CVS48_RS12880	COG0412	Dienelactone hydrolase
CVS48_RS12890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CVS48_RS12890	COG0678	peroxiredoxin activity
CVS48_RS12905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CVS48_RS12945	COG0667	Aldo Keto reductase
CVS48_RS12950	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CVS48_RS12955	COG4535	Mg2 and Co2 transporter CorC
CVS48_RS12960	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CVS48_RS12965	COG1702	phosphate starvation-inducible protein PhoH
CVS48_RS12970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVS48_RS12985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVS48_RS12995	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS48_RS13000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS48_RS13005	COG1862	Preprotein translocase
CVS48_RS13010	COG0343	queuine tRNA-ribosyltransferase activity
CVS48_RS13015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CVS48_RS13020	COG2027	D-alanyl-D-alanine carboxypeptidase
CVS48_RS13025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CVS48_RS13030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVS48_RS13030	COG1648	precorrin-2 dehydrogenase activity
CVS48_RS13040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS48_RS13045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_RS13050	COG1116	anion transmembrane transporter activity
CVS48_RS13055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS48_RS13060	COG0243	molybdopterin cofactor binding
CVS48_RS13070	COG4575	ribosome binding
CVS48_RS13085	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CVS48_RS13090	COG0741	lytic transglycosylase activity
CVS48_RS13095	COG0436	Aminotransferase
CVS48_RS13105	COG0281	malic enzyme
CVS48_RS13105	COG0280	phosphate acetyltransferase
CVS48_RS13115	COG2732	(Barnase) inhibitor
CVS48_RS13120	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CVS48_RS13130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CVS48_RS13135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CVS48_RS13140	COG0126	phosphoglycerate kinase activity
CVS48_RS13155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CVS48_RS13160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CVS48_RS13175	COG0625	glutathione transferase activity
CVS48_RS13205	COG0306	phosphate transporter
CVS48_RS13215	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVS48_RS13225	COG0739	heme binding
CVS48_RS13235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CVS48_RS13250	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CVS48_RS13255	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CVS48_RS13260	COG3639	organic phosphonate transmembrane transporter activity
CVS48_RS13280	COG0583	DNA-binding transcription factor activity
CVS48_RS13285	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CVS48_RS13290	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CVS48_RS13295	COG3454	Phosphonate metabolism
CVS48_RS13300	COG2188	Transcriptional regulator
CVS48_RS13305	COG3624	Phosphonate C-P lyase system protein PhnG
CVS48_RS13315	COG3626	phosphonate metabolism
CVS48_RS13320	COG3627	carbon phosphorus lyase activity
CVS48_RS13325	COG4107	phosphonate C-P lyase system protein PhnK
CVS48_RS13330	COG4778	phosphonate C-P lyase system protein PhnL
CVS48_RS13335	COG3454	Phosphonate metabolism
CVS48_RS13350	COG1301	dicarboxylic acid transport
CVS48_RS13370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS48_RS13390	COG4172	Belongs to the ABC transporter superfamily
CVS48_RS13395	COG0154	amidase activity
CVS48_RS13410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CVS48_RS13415	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CVS48_RS13420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CVS48_RS13425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CVS48_RS13430	COG0009	L-threonylcarbamoyladenylate synthase
CVS48_RS13435	COG1414	Transcriptional regulator
CVS48_RS13440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CVS48_RS13455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS13460	COG1414	Transcriptional regulator
CVS48_RS13465	COG0010	Belongs to the arginase family
CVS48_RS13470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS13475	COG0765	amino acid transport
CVS48_RS13480	COG1126	abc transporter atp-binding protein
CVS48_RS13485	COG0028	Belongs to the TPP enzyme family
CVS48_RS13525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CVS48_RS13550	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS13555	COG0028	Belongs to the TPP enzyme family
CVS48_RS13560	COG0583	DNA-binding transcription factor activity
CVS48_RS13565	COG4974	Belongs to the 'phage' integrase family
CVS48_RS13590	COG0601	transmembrane transport
CVS48_RS13595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS13620	COG0583	DNA-binding transcription factor activity
CVS48_RS13625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_RS13635	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS13640	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CVS48_RS13655	COG1686	Belongs to the peptidase S11 family
CVS48_RS13680	COG2205	protein histidine kinase activity
CVS48_RS13695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVS48_RS13705	COG2271	Major facilitator Superfamily
CVS48_RS13715	COG1074	ATP-dependent DNA helicase activity
CVS48_RS13725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CVS48_RS13740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS13745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS48_RS13755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_RS13770	COG0745	RESPONSE REGULATOR receiver
CVS48_RS13785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVS48_RS13790	COG0505	Belongs to the CarA family
CVS48_RS13795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CVS48_RS13815	COG3842	ATPase activity
CVS48_RS13835	COG2233	PERMEase
CVS48_RS13840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVS48_RS13845	COG1534	Rna-binding protein
CVS48_RS13850	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CVS48_RS13855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVS48_RS13865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVS48_RS13875	COG0248	Ppx GppA phosphatase
CVS48_RS13900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CVS48_RS13910	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS13915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_RS13920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS13930	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_RS13935	COG0028	Belongs to the TPP enzyme family
CVS48_RS13950	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS13955	COG2186	Transcriptional regulator
CVS48_RS13975	COG1090	epimerase
CVS48_RS13985	COG3685	Protein conserved in bacteria
CVS48_RS14010	COG0583	DNA-binding transcription factor activity
CVS48_RS14015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_RS14020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS14055	COG1335	isochorismatase
CVS48_RS14060	COG0583	DNA-binding transcription factor activity
CVS48_RS14065	COG2207	Transcriptional regulator
CVS48_RS14070	COG0667	Aldo Keto reductase
CVS48_RS14095	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CVS48_RS14110	COG0500	methyltransferase
CVS48_RS14115	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS14120	COG3321	synthase
CVS48_RS14120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVS48_RS14120	COG0604	alcohol dehydrogenase
CVS48_RS14120	COG4221	oxidoreductase activity
CVS48_RS14135	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_RS14145	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS14155	COG3246	L-lysine catabolic process to acetate
CVS48_RS14160	COG0371	Dehydrogenase
CVS48_RS14165	COG1802	Transcriptional regulator
CVS48_RS14170	COG3959	Transketolase, thiamine diphosphate binding domain
CVS48_RS14175	COG3958	Transketolase
CVS48_RS14180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CVS48_RS14190	COG3938	Belongs to the proline racemase family
CVS48_RS14195	COG0395	ABC-type sugar transport system, permease component
CVS48_RS14200	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_RS14260	COG3264	Mechanosensitive ion channel
CVS48_RS14260	COG1511	domain protein
CVS48_RS14265	COG0583	DNA-binding transcription factor activity
CVS48_RS14270	COG0427	acetyl-CoA hydrolase
CVS48_RS14305	COG2204	response regulator
CVS48_RS14310	COG4191	Histidine kinase
CVS48_RS14315	COG1301	dicarboxylic acid transport
CVS48_RS14325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CVS48_RS14330	COG0799	negative regulation of ribosome biogenesis
CVS48_RS14335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CVS48_RS14345	COG0151	Belongs to the GarS family
CVS48_RS14350	COG0217	transcriptional regulatory protein
CVS48_RS14355	COG0433	COG0433 Predicted ATPase
CVS48_RS14360	COG0473	3-isopropylmalate dehydrogenase activity
CVS48_RS14370	COG2814	Major facilitator Superfamily
CVS48_RS14375	COG1566	PFAM secretion protein HlyD family protein
CVS48_RS14415	COG3391	amine dehydrogenase activity
CVS48_RS14425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CVS48_RS14445	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CVS48_RS14450	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CVS48_RS14460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CVS48_RS14470	COG0187	DNA topoisomerase II activity
CVS48_RS14485	COG2311	Membrane
CVS48_RS14495	COG2358	TRAP transporter, solute receptor (TAXI family
CVS48_RS14500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVS48_RS14525	COG0662	Cupin 2, conserved barrel domain protein
CVS48_RS14530	COG5285	phytanoyl-CoA dioxygenase
CVS48_RS14535	COG3217	Mosc domain protein beta barrel domain protein
CVS48_RS14535	COG0633	Ferredoxin
CVS48_RS14540	COG2076	Multidrug Resistance protein
CVS48_RS14555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_RS14610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVS48_RS14615	COG0425	Belongs to the sulfur carrier protein TusA family
CVS48_RS14630	COG0228	four-way junction DNA binding
CVS48_RS14635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CVS48_RS14640	COG0336	Belongs to the RNA methyltransferase TrmD family
CVS48_RS14645	COG1396	sequence-specific DNA binding
CVS48_RS14650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS14655	COG0765	amino acid transport
CVS48_RS14660	COG1126	abc transporter atp-binding protein
CVS48_RS14665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_RS14675	COG0525	valine-tRNA ligase activity
CVS48_RS14680	COG0105	UTP biosynthetic process
CVS48_RS14685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CVS48_RS14705	COG2976	Protein conserved in bacteria
CVS48_RS14710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS48_RS14715	COG1160	GTP binding
CVS48_RS14720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVS48_RS14725	COG1923	regulation of RNA biosynthetic process
CVS48_RS14730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CVS48_RS14735	COG0330	HflC and HflK could
CVS48_RS14740	COG0330	HflC and HflK could
CVS48_RS14745	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CVS48_RS14750	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CVS48_RS14755	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CVS48_RS14760	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CVS48_RS14830	COG4964	Belongs to the GSP D family
CVS48_RS14860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CVS48_RS14870	COG1295	ribonuclease BN
CVS48_RS14880	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CVS48_RS14890	COG2205	protein histidine kinase activity
CVS48_RS14905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CVS48_RS14910	COG4783	chaperone-mediated protein folding
CVS48_RS14955	COG1538	Outer membrane efflux protein
CVS48_RS14975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CVS48_RS14985	COG0101	tRNA pseudouridine synthase activity
CVS48_RS14990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CVS48_RS14995	COG0135	phosphoribosylanthranilate isomerase activity
CVS48_RS15030	COG2832	Protein of unknown function (DUF454)
CVS48_RS15035	COG0129	dihydroxy-acid dehydratase activity
CVS48_RS15040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_RS15045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_RS15050	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CVS48_RS15055	COG1609	Transcriptional regulator
CVS48_RS15075	COG4172	Belongs to the ABC transporter superfamily
CVS48_RS15080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS15085	COG0601	transmembrane transport
CVS48_RS15110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVS48_RS15115	COG2197	response regulator
CVS48_RS15120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CVS48_RS15125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CVS48_RS15140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS48_RS15145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CVS48_RS15150	COG0004	ammonium transporteR
CVS48_RS15155	COG0347	Belongs to the P(II) protein family
CVS48_RS15160	COG2960	long-chain fatty acid transporting porin activity
CVS48_RS15170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CVS48_RS15175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CVS48_RS15180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CVS48_RS15185	COG0072	phenylalanine-tRNA ligase activity
CVS48_RS15185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS48_RS15215	COG2267	carboxylic ester hydrolase activity
CVS48_RS15225	COG0384	phenazine biosynthesis protein PhzF
CVS48_RS15230	COG0456	acetyltransferase
CVS48_RS15260	COG1522	sequence-specific DNA binding
CVS48_RS15300	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS15315	COG0583	DNA-binding transcription factor activity
CVS48_RS15330	COG5265	(ABC) transporter
CVS48_RS15335	COG0656	L-ascorbic acid biosynthetic process
CVS48_RS15350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVS48_RS15365	COG2223	nitrite transmembrane transporter activity
CVS48_RS15395	COG1610	YqeY-like protein
CVS48_RS15405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS48_RS15410	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS15420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS48_RS15460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVS48_RS15470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVS48_RS15475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVS48_RS15500	COG1959	2 iron, 2 sulfur cluster binding
CVS48_RS15505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_RS15510	COG0506	proline dehydrogenase activity
CVS48_RS15530	COG2814	Major facilitator Superfamily
CVS48_RS15540	COG0583	DNA-binding transcription factor activity
CVS48_RS15545	COG0625	glutathione transferase activity
CVS48_RS15560	COG2814	Major facilitator Superfamily
CVS48_RS15565	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS15570	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS15605	COG1280	lysine exporter protein (LysE YggA)
CVS48_RS15625	COG0697	spore germination
CVS48_RS15630	COG0697	spore germination
CVS48_RS15645	COG1024	Enoyl-CoA hydratase
CVS48_RS15650	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS15660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS48_RS15665	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CVS48_RS15670	COG4804	nuclease activity
CVS48_RS15675	COG2226	methyltransferase
CVS48_RS15705	COG4235	cytochrome complex assembly
CVS48_RS15715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS48_RS15745	COG4133	protoheme IX ABC transporter activity
CVS48_RS15750	COG3005	denitrification pathway
CVS48_RS15755	COG3043	anaerobic respiration
CVS48_RS15770	COG4459	periplasmic nitrate reductase
CVS48_RS15775	COG3246	L-lysine catabolic process to acetate
CVS48_RS15780	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_RS15785	COG0583	DNA-binding transcription factor activity
CVS48_RS15790	COG2336	PFAM SpoVT AbrB
CVS48_RS15805	COG0129	dihydroxy-acid dehydratase activity
CVS48_RS15810	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS15815	COG5001	Diguanylate cyclase
CVS48_RS15820	COG1024	Enoyl-CoA hydratase
CVS48_RS15830	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS15835	COG0583	DNA-binding transcription factor activity
CVS48_RS15840	COG2610	gluconate transmembrane transporter activity
CVS48_RS15855	COG2188	Transcriptional regulator
CVS48_RS15860	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS15885	COG4977	sequence-specific DNA binding
CVS48_RS15895	COG5265	(ABC) transporter
CVS48_RS15910	COG1132	(ABC) transporter
CVS48_RS15925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_RS15955	COG0583	DNA-binding transcription factor activity
CVS48_RS16005	COG1696	Membrane protein involved in D-alanine export
CVS48_RS16010	COG2186	Transcriptional regulator
CVS48_RS16015	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS16020	COG0307	riboflavin synthase, alpha
CVS48_RS16030	COG0235	Class ii aldolase
CVS48_RS16035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS48_RS16045	COG0789	Transcriptional regulator
CVS48_RS16055	COG1595	DNA-templated transcription, initiation
CVS48_RS16065	COG4774	siderophore transport
CVS48_RS16075	COG0022	dehydrogenase e1 component
CVS48_RS16105	COG3712	iron ion homeostasis
CVS48_RS16115	COG0165	Argininosuccinate lyase
CVS48_RS16120	COG0668	transmembrane transport
CVS48_RS16180	COG2165	general secretion pathway protein
CVS48_RS16190	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS16200	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS16205	COG0583	DNA-binding transcription factor activity
CVS48_RS16235	COG0583	DNA-binding transcription factor activity
CVS48_RS16245	COG0747	negative chemotaxis
CVS48_RS16250	COG0601	transmembrane transport
CVS48_RS16255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS16260	COG4172	Belongs to the ABC transporter superfamily
CVS48_RS16270	COG4681	YaeQ
CVS48_RS16280	COG4221	oxidoreductase activity
CVS48_RS16295	COG0642	Histidine kinase
CVS48_RS16300	COG0745	RESPONSE REGULATOR receiver
CVS48_RS16310	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS16355	COG0625	glutathione transferase activity
CVS48_RS16360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS48_RS16370	COG0165	Argininosuccinate lyase
CVS48_RS16380	COG1595	DNA-templated transcription, initiation
CVS48_RS16385	COG3712	iron ion homeostasis
CVS48_RS16395	COG1733	regulation of RNA biosynthetic process
CVS48_RS16400	COG0604	alcohol dehydrogenase
CVS48_RS16415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CVS48_RS16450	COG4268	DNA restriction-modification system
CVS48_RS16455	COG1401	restriction endodeoxyribonuclease activity
CVS48_RS16500	COG2188	Transcriptional regulator
CVS48_RS16530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CVS48_RS16535	COG0066	3-isopropylmalate dehydratase activity
CVS48_RS16550	COG1335	isochorismatase
CVS48_RS16575	COG3161	chorismate lyase activity
CVS48_RS16620	COG1187	pseudouridine synthase activity
CVS48_RS16625	COG0583	DNA-binding transcription factor activity
CVS48_RS16645	COG2261	transglycosylase associated protein
CVS48_RS16650	COG1999	signal sequence binding
CVS48_RS16660	COG0339	signal peptide processing
CVS48_RS16665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CVS48_RS16670	COG4566	intracellular signal transduction
CVS48_RS16680	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CVS48_RS16685	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS48_RS16690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS48_RS16735	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CVS48_RS16745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVS48_RS16785	COG2204	response regulator
CVS48_RS16795	COG0835	chemotaxis
CVS48_RS16800	COG0840	transmembrane signaling receptor activity
CVS48_RS16805	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CVS48_RS16810	COG2201	protein-glutamate methylesterase activity
CVS48_RS16815	COG0745	RESPONSE REGULATOR receiver
CVS48_RS16820	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CVS48_RS16825	COG0840	transmembrane signaling receptor activity
CVS48_RS16835	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CVS48_RS16850	COG2747	anti-sigma28 factor FlgM
CVS48_RS16860	COG1815	bacterial-type flagellum-dependent cell motility
CVS48_RS16865	COG1558	bacterial-type flagellum-dependent cell motility
CVS48_RS16870	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CVS48_RS16880	COG4787	bacterial-type flagellum-dependent cell motility
CVS48_RS16915	COG0840	transmembrane signaling receptor activity
CVS48_RS16920	COG0840	transmembrane signaling receptor activity
CVS48_RS16935	COG0840	transmembrane signaling receptor activity
CVS48_RS16945	COG1987	bacterial-type flagellum assembly
CVS48_RS16970	COG1580	Controls the rotational direction of flagella during chemotaxis
CVS48_RS16990	COG1317	bacterial-type flagellum organization
CVS48_RS16995	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CVS48_RS17005	COG1677	Flagellar hook-basal body complex protein FliE
CVS48_RS17015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CVS48_RS17035	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CVS48_RS17055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS17070	COG0285	dihydrofolate synthase activity
CVS48_RS17080	COG1286	toxin biosynthetic process
CVS48_RS17095	COG1451	nucleotide metabolic process
CVS48_RS17100	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CVS48_RS17110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CVS48_RS17115	COG0024	Methionine aminopeptidase
CVS48_RS17120	COG0052	Belongs to the universal ribosomal protein uS2 family
CVS48_RS17125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CVS48_RS17130	COG0528	UMP kinase activity
CVS48_RS17135	COG0233	cytoplasmic translational termination
CVS48_RS17140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CVS48_RS17145	COG0575	Belongs to the CDS family
CVS48_RS17150	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CVS48_RS17155	COG0750	zinc metalloprotease
CVS48_RS17160	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS48_RS17165	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CVS48_RS17170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS48_RS17175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVS48_RS17190	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CVS48_RS17195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVS48_RS17220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVS48_RS17220	COG2169	Transcriptional regulator
CVS48_RS17225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVS48_RS17225	COG0519	Catalyzes the synthesis of GMP from XMP
CVS48_RS17245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CVS48_RS17250	COG2867	negative regulation of translational initiation
CVS48_RS17255	COG2914	Belongs to the UPF0125 (RnfH) family
CVS48_RS17260	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS17265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CVS48_RS17290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CVS48_RS17295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CVS48_RS17300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CVS48_RS17305	COG0084	hydrolase, TatD family'
CVS48_RS17320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS17325	COG0765	amino acid transport
CVS48_RS17330	COG1126	abc transporter atp-binding protein
CVS48_RS17335	COG0010	Belongs to the arginase family
CVS48_RS17340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CVS48_RS17345	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_RS17370	COG0625	glutathione transferase activity
CVS48_RS17380	COG1522	sequence-specific DNA binding
CVS48_RS17385	COG0386	Belongs to the glutathione peroxidase family
CVS48_RS17400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS17415	COG2259	Doxx family
CVS48_RS17440	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS17535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS48_RS17540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS48_RS17550	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CVS48_RS17555	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CVS48_RS17560	COG0745	RESPONSE REGULATOR receiver
CVS48_RS17565	COG5002	protein histidine kinase activity
CVS48_RS17570	COG2070	2-Nitropropane dioxygenase
CVS48_RS17575	COG1414	Transcriptional regulator
CVS48_RS17580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_RS17615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_RS17625	COG1328	CTP reductase activity
CVS48_RS17690	COG1763	Mo-molybdopterin cofactor biosynthetic process
CVS48_RS17695	COG5295	Hep Hag repeat protein
CVS48_RS17705	COG0477	Major facilitator Superfamily
CVS48_RS17715	COG0583	DNA-binding transcription factor activity
CVS48_RS17740	COG0861	Integral membrane protein TerC family
CVS48_RS17745	COG0583	DNA-binding transcription factor activity
CVS48_RS17760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_RS17775	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_RS17795	COG3706	GGDEF domain
CVS48_RS17810	COG0583	DNA-binding transcription factor activity
CVS48_RS17815	COG3119	arylsulfatase activity
CVS48_RS17830	COG0251	oxidation-reduction process
CVS48_RS17845	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS17860	COG1304	FMN binding
CVS48_RS17890	COG0436	Aminotransferase
CVS48_RS17895	COG0765	amino acid transport
CVS48_RS17905	COG1126	abc transporter atp-binding protein
CVS48_RS17920	COG0583	DNA-binding transcription factor activity
CVS48_RS17930	COG3706	GGDEF domain
CVS48_RS17945	COG4566	intracellular signal transduction
CVS48_RS17965	COG0583	DNA-binding transcription factor activity
CVS48_RS18005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS48_RS18010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS18015	COG0765	amino acid transport
CVS48_RS18020	COG1126	abc transporter atp-binding protein
CVS48_RS18025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CVS48_RS18035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS48_RS18050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_RS18055	COG1126	abc transporter atp-binding protein
CVS48_RS18060	COG0765	amino acid transport
CVS48_RS18065	COG4597	amino acid ABC transporter
CVS48_RS18070	COG0436	Aminotransferase
CVS48_RS18075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS18085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_RS18100	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CVS48_RS18135	COG2721	sulfolactate sulfo-lyase activity
CVS48_RS18140	COG3386	PFAM SMP-30 Gluconolaconase
CVS48_RS18145	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS18175	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CVS48_RS18185	COG1335	isochorismatase
CVS48_RS18225	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS18235	COG0028	Belongs to the TPP enzyme family
CVS48_RS18245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_RS18245	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CVS48_RS18255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_RS18270	COG0444	Belongs to the ABC transporter superfamily
CVS48_RS18275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS18285	COG0747	negative chemotaxis
CVS48_RS18290	COG2186	Transcriptional regulator
CVS48_RS18310	COG4172	Belongs to the ABC transporter superfamily
CVS48_RS18315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS18355	COG1408	metallophosphoesterase
CVS48_RS18360	COG4773	Receptor
CVS48_RS18375	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CVS48_RS18390	COG0366	Alpha amylase catalytic
CVS48_RS18395	COG0366	Alpha amylase catalytic
CVS48_RS18400	COG0297	glycogen (starch) synthase activity
CVS48_RS18405	COG0028	Belongs to the TPP enzyme family
CVS48_RS18430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS48_RS18435	COG3568	Endonuclease Exonuclease Phosphatase
CVS48_RS18470	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CVS48_RS18475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CVS48_RS18480	COG4770	biotin carboxylase activity
CVS48_RS18490	COG1309	transcriptional regulator
CVS48_RS18505	COG0154	amidase activity
CVS48_RS18510	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS18515	COG3048	D-serine ammonia-lyase activity
CVS48_RS18520	COG0583	DNA-binding transcription factor activity
CVS48_RS18550	COG0589	response to stress
CVS48_RS18560	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CVS48_RS18565	COG0517	IMP dehydrogenase activity
CVS48_RS18580	COG2197	response regulator
CVS48_RS18585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVS48_RS18595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CVS48_RS18605	COG2072	flavoprotein involved in K transport
CVS48_RS18620	COG0431	NADPH-dependent FMN reductase
CVS48_RS18625	COG4172	Belongs to the ABC transporter superfamily
CVS48_RS18630	COG0444	Belongs to the ABC transporter superfamily
CVS48_RS18635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS18640	COG0601	transmembrane transport
CVS48_RS18645	COG0747	negative chemotaxis
CVS48_RS18665	COG3971	2-oxopent-4-enoate hydratase activity
CVS48_RS18680	COG2146	nitrite reductase [NAD(P)H] activity
CVS48_RS18705	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS48_RS18730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CVS48_RS18735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CVS48_RS18735	COG2010	Cytochrome c
CVS48_RS18750	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVS48_RS18775	COG1201	RNA secondary structure unwinding
CVS48_RS18780	COG1793	dna ligase
CVS48_RS18785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CVS48_RS18785	COG1793	dna ligase
CVS48_RS18795	COG0500	methyltransferase
CVS48_RS18815	COG0531	amino acid
CVS48_RS18820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVS48_RS18825	COG1959	2 iron, 2 sulfur cluster binding
CVS48_RS18840	COG1619	proteins homologs of microcin C7 resistance protein MccF
CVS48_RS18845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CVS48_RS18870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_RS18890	COG1846	Transcriptional regulator
CVS48_RS18895	COG2807	transmembrane transport
CVS48_RS18910	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_RS18910	COG1024	Enoyl-CoA hydratase
CVS48_RS18935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CVS48_RS18950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CVS48_RS18955	COG1253	flavin adenine dinucleotide binding
CVS48_RS18975	COG2863	cytochrome
CVS48_RS18990	COG2200	EAL domain
CVS48_RS18990	COG2199	diguanylate cyclase activity
CVS48_RS19005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS48_RS19040	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS19070	COG2204	response regulator
CVS48_RS19075	COG2204	response regulator
CVS48_RS19080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CVS48_RS19110	COG2814	Major facilitator Superfamily
CVS48_RS19125	COG2203	Gaf domain
CVS48_RS19125	COG2199	diguanylate cyclase activity
CVS48_RS19125	COG2200	EAL domain
CVS48_RS19130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS48_RS19135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_RS19160	COG0488	(ABC) transporter
CVS48_RS19165	COG0688	phosphatidylethanolamine metabolic process
CVS48_RS19175	COG1408	metallophosphoesterase
CVS48_RS19190	COG1464	Belongs to the NlpA lipoprotein family
CVS48_RS19195	COG0010	Belongs to the arginase family
CVS48_RS19200	COG1414	Transcriptional regulator
CVS48_RS19225	COG2363	Small membrane protein
CVS48_RS19230	COG0697	spore germination
CVS48_RS19240	COG2133	pyrroloquinoline quinone binding
CVS48_RS19245	COG0625	glutathione transferase activity
CVS48_RS19260	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CVS48_RS19265	COG1794	racemase activity, acting on amino acids and derivatives
CVS48_RS19285	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_RS19295	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CVS48_RS19305	COG1653	transport
CVS48_RS19310	COG1175	transmembrane transport
CVS48_RS19315	COG0395	ABC-type sugar transport system, permease component
CVS48_RS19320	COG3842	ATPase activity
CVS48_RS19335	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS19335	COG3321	synthase
CVS48_RS19335	COG0604	alcohol dehydrogenase
CVS48_RS19340	COG0156	8-amino-7-oxononanoate synthase activity
CVS48_RS19345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CVS48_RS19345	COG0517	IMP dehydrogenase activity
CVS48_RS19375	COG1596	polysaccharide export
CVS48_RS19395	COG0783	Belongs to the Dps family
CVS48_RS19400	COG0583	DNA-binding transcription factor activity
CVS48_RS19405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CVS48_RS19430	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS19440	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS48_RS19450	COG3842	ATPase activity
CVS48_RS19455	COG1741	Belongs to the pirin family
CVS48_RS19460	COG1741	Belongs to the pirin family
CVS48_RS19465	COG0583	DNA-binding transcription factor activity
CVS48_RS19470	COG2204	response regulator
CVS48_RS19480	COG0174	glutamine synthetase
CVS48_RS19485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVS48_RS19490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CVS48_RS19505	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS19515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CVS48_RS19520	COG1561	YicC-like family, N-terminal region
CVS48_RS19525	COG0583	DNA-binding transcription factor activity
CVS48_RS19530	COG0833	amino acid
CVS48_RS19535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CVS48_RS19550	COG0791	NLP P60 protein
CVS48_RS19555	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS19560	COG2863	cytochrome
CVS48_RS19565	COG3258	Cytochrome c
CVS48_RS19570	COG0194	GDP metabolic process
CVS48_RS19575	COG1758	RNA polymerase activity
CVS48_RS19580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVS48_RS19585	COG1126	abc transporter atp-binding protein
CVS48_RS19590	COG0765	amino acid transport
CVS48_RS19595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS19635	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_RS19640	COG4336	lyase activity
CVS48_RS19655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_RS19670	COG0583	DNA-binding transcription factor activity
CVS48_RS19690	COG0560	Phosphoserine phosphatase
CVS48_RS19695	COG0583	DNA-binding transcription factor activity
CVS48_RS19700	COG3842	ATPase activity
CVS48_RS19705	COG1178	ABC-type Fe3 transport system permease component
CVS48_RS19715	COG4181	ATPase activity
CVS48_RS19725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS48_RS19730	COG0584	glycerophosphoryl diester phosphodiesterase
CVS48_RS19735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CVS48_RS19755	COG0678	peroxiredoxin activity
CVS48_RS19755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CVS48_RS19770	COG0789	Transcriptional regulator
CVS48_RS19775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVS48_RS19780	COG2814	Major facilitator Superfamily
CVS48_RS19785	COG0583	DNA-binding transcription factor activity
CVS48_RS19815	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVS48_RS19825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CVS48_RS19830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CVS48_RS19835	COG2252	PERMEase
CVS48_RS19845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS48_RS19850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS48_RS19870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS48_RS19880	COG0488	(ABC) transporter
CVS48_RS19885	COG1619	proteins homologs of microcin C7 resistance protein MccF
CVS48_RS19890	COG0590	tRNA wobble adenosine to inosine editing
CVS48_RS19910	COG2212	antiporter activity
CVS48_RS19915	COG1863	multisubunit Na H antiporter MnhE subunit
CVS48_RS19920	COG0651	ATP synthesis coupled electron transport
CVS48_RS19925	COG1006	Multisubunit Na H antiporter MnhC subunit
CVS48_RS19930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CVS48_RS19930	COG2111	Na H antiporter
CVS48_RS19955	COG0420	3'-5' exonuclease activity
CVS48_RS19960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_RS19990	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS19995	COG3634	alkyl hydroperoxide reductase activity
CVS48_RS20015	COG0395	ABC-type sugar transport system, permease component
CVS48_RS20025	COG3842	ATPase activity
CVS48_RS20030	COG3842	ATPase activity
CVS48_RS20055	COG2130	NADP-dependent
CVS48_RS20060	COG1309	transcriptional regulator
CVS48_RS20070	COG1131	(ABC) transporter
CVS48_RS20075	COG0842	Transport permease protein
CVS48_RS20090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CVS48_RS20120	COG1902	pentaerythritol trinitrate reductase activity
CVS48_RS20135	COG0602	queuosine metabolic process
CVS48_RS20140	COG0720	synthase
CVS48_RS20160	COG1566	PFAM secretion protein HlyD family protein
CVS48_RS20165	COG1538	Outer membrane efflux protein
CVS48_RS20175	COG0028	Belongs to the TPP enzyme family
CVS48_RS20185	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS20195	COG0400	carboxylic ester hydrolase activity
CVS48_RS20200	COG0833	amino acid
CVS48_RS20215	COG0587	DNA-directed DNA polymerase activity
CVS48_RS20235	COG0765	amino acid transport
CVS48_RS20240	COG0765	amino acid transport
CVS48_RS20245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS20255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_RS20275	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CVS48_RS20280	COG1414	Transcriptional regulator
CVS48_RS20300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS48_RS20305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS48_RS20315	COG0667	Aldo Keto reductase
CVS48_RS20325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CVS48_RS20330	COG1802	Transcriptional regulator
CVS48_RS20335	COG0747	negative chemotaxis
CVS48_RS20340	COG0601	transmembrane transport
CVS48_RS20345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS20350	COG0444	Belongs to the ABC transporter superfamily
CVS48_RS20355	COG4608	Belongs to the ABC transporter superfamily
CVS48_RS20380	COG1309	transcriptional regulator
CVS48_RS20395	COG1683	Conserved Protein
CVS48_RS20405	COG2207	Transcriptional regulator
CVS48_RS20415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CVS48_RS20420	COG1360	Flagellar Motor Protein
CVS48_RS20425	COG3795	YCII-related domain
CVS48_RS20430	COG4691	Plasmid stability protein
CVS48_RS20435	COG1487	ribonuclease activity
CVS48_RS20440	COG3795	YCII-related domain
CVS48_RS20450	COG4941	Belongs to the sigma-70 factor family
CVS48_RS20460	COG0697	spore germination
CVS48_RS20480	COG3415	Transposase
CVS48_RS20480	COG2801	Transposase and inactivated derivatives
CVS48_RS20485	COG0583	DNA-binding transcription factor activity
CVS48_RS20490	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS20500	COG1846	Transcriptional regulator
CVS48_RS20510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_RS20520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CVS48_RS20545	COG2885	chlorophyll binding
CVS48_RS20575	COG0625	glutathione transferase activity
CVS48_RS20580	COG2032	superoxide dismutase activity
CVS48_RS20585	COG2733	membrane
CVS48_RS20590	COG0628	permease
CVS48_RS20595	COG0583	DNA-binding transcription factor activity
CVS48_RS20600	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_RS20600	COG1024	Enoyl-CoA hydratase
CVS48_RS20605	COG0183	Belongs to the thiolase family
CVS48_RS20610	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS20615	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS20620	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS20665	COG5001	Diguanylate cyclase
CVS48_RS20665	COG4251	negative regulation of phosphorylation
CVS48_RS20665	COG3706	GGDEF domain
CVS48_RS20665	COG2203	Gaf domain
CVS48_RS20695	COG0840	transmembrane signaling receptor activity
CVS48_RS20700	COG0154	amidase activity
CVS48_RS20705	COG0583	DNA-binding transcription factor activity
CVS48_RS20770	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CVS48_RS20775	COG1942	4-Oxalocrotonate Tautomerase
CVS48_RS20800	COG4221	oxidoreductase activity
CVS48_RS20805	COG1902	pentaerythritol trinitrate reductase activity
CVS48_RS20820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CVS48_RS20830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS48_RS20835	COG1132	(ABC) transporter
CVS48_RS20845	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS20865	COG4221	oxidoreductase activity
CVS48_RS20870	COG0625	glutathione transferase activity
CVS48_RS20900	COG0583	DNA-binding transcription factor activity
CVS48_RS20930	COG0519	Catalyzes the synthesis of GMP from XMP
CVS48_RS20930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVS48_RS20955	COG0583	DNA-binding transcription factor activity
CVS48_RS20965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS48_RS20985	COG0633	Ferredoxin
CVS48_RS20990	COG0288	reversible hydration of carbon dioxide
CVS48_RS21010	COG2072	flavoprotein involved in K transport
CVS48_RS21015	COG0601	transmembrane transport
CVS48_RS21020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS21025	COG0444	Belongs to the ABC transporter superfamily
CVS48_RS21030	COG4608	Belongs to the ABC transporter superfamily
CVS48_RS21035	COG0747	negative chemotaxis
CVS48_RS21065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CVS48_RS21075	COG1204	response to ionizing radiation
CVS48_RS21085	COG3328	transposase activity
CVS48_RS21090	COG1414	Transcriptional regulator
CVS48_RS21095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CVS48_RS21115	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS48_RS21120	COG3971	2-oxopent-4-enoate hydratase activity
CVS48_RS21215	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS21220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_RS21230	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CVS48_RS21240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS48_RS21250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS48_RS21255	COG0657	acetylesterase activity
CVS48_RS21270	COG0583	DNA-binding transcription factor activity
CVS48_RS21280	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS21290	COG0583	DNA-binding transcription factor activity
CVS48_RS21295	COG0047	phosphoribosylformylglycinamidine synthase activity
CVS48_RS21295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CVS48_RS21305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_RS21305	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CVS48_RS21310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_RS21320	COG0613	PHP domain protein
CVS48_RS21330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS48_RS21340	COG0583	DNA-binding transcription factor activity
CVS48_RS21345	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS21370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS48_RS21370	COG2146	nitrite reductase [NAD(P)H] activity
CVS48_RS21375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS48_RS21375	COG2146	nitrite reductase [NAD(P)H] activity
CVS48_RS21380	COG2116	formate transmembrane transporter activity
CVS48_RS21385	COG0515	serine threonine protein kinase
CVS48_RS21395	COG3707	response regulator
CVS48_RS21400	COG0477	Major facilitator Superfamily
CVS48_RS21415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_RS21420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_RS21430	COG1850	ribulose-bisphosphate carboxylase activity
CVS48_RS21450	COG3210	domain, Protein
CVS48_RS21450	COG3210	domain, Protein
CVS48_RS21465	COG1204	response to ionizing radiation
CVS48_RS21535	COG0583	DNA-binding transcription factor activity
CVS48_RS21545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS48_RS21675	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS21695	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS21700	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS21710	COG0583	DNA-binding transcription factor activity
CVS48_RS21720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CVS48_RS21735	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CVS48_RS21740	COG2814	Major facilitator Superfamily
CVS48_RS21745	COG4604	ABC transporter, ATP-binding protein
CVS48_RS21750	COG4605	iron ion homeostasis
CVS48_RS21760	COG4607	ABC-type enterochelin transport system periplasmic component
CVS48_RS21765	COG4771	TonB-dependent receptor
CVS48_RS21770	COG0745	RESPONSE REGULATOR receiver
CVS48_RS21780	COG4771	TonB-dependent receptor
CVS48_RS21790	COG1136	(ABC) transporter
CVS48_RS21815	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS21820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CVS48_RS21830	COG1309	transcriptional regulator
CVS48_RS21840	COG1022	Amp-dependent synthetase and ligase
CVS48_RS21880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS21890	COG0583	DNA-binding transcription factor activity
CVS48_RS21895	COG1803	Methylglyoxal synthase
CVS48_RS21900	COG2975	iron-sulfur cluster assembly
CVS48_RS21905	COG0633	Ferredoxin
CVS48_RS21910	COG0443	Heat shock 70 kDa protein
CVS48_RS21915	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CVS48_RS21920	COG0316	Belongs to the HesB IscA family
CVS48_RS21925	COG0822	iron-sulfur transferase activity
CVS48_RS21930	COG1104	cysteine desulfurase activity
CVS48_RS21940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CVS48_RS21945	COG0556	nucleotide-excision repair
CVS48_RS21955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CVS48_RS21960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CVS48_RS21965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CVS48_RS21970	COG0740	serine-type endopeptidase activity
CVS48_RS21975	COG0544	peptidyl-prolyl cis-trans isomerase activity
CVS48_RS21980	COG0501	Belongs to the peptidase M48B family
CVS48_RS21990	COG1278	Cold shock
CVS48_RS22005	COG1278	Cold shock
CVS48_RS22035	COG0583	DNA-binding transcription factor activity
CVS48_RS22050	COG1309	transcriptional regulator
CVS48_RS22070	COG3008	intermembrane lipid transfer
CVS48_RS22075	COG0456	acetyltransferase
CVS48_RS22085	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CVS48_RS22100	COG0277	FAD linked oxidase domain protein
CVS48_RS22105	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CVS48_RS22110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CVS48_RS22115	COG2271	Major facilitator Superfamily
CVS48_RS22145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS22150	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_RS22150	COG1024	Enoyl-CoA hydratase
CVS48_RS22175	COG2171	N-acyltransferase activity
CVS48_RS22185	COG2890	protein-(glutamine-N5) methyltransferase activity
CVS48_RS22190	COG0488	(ABC) transporter
CVS48_RS22205	COG4771	TonB-dependent receptor
CVS48_RS22210	COG1858	cytochrome C peroxidase
CVS48_RS22220	COG0210	DNA helicase
CVS48_RS22235	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS48_RS22235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS48_RS22240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CVS48_RS22245	COG0196	riboflavin kinase activity
CVS48_RS22250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CVS48_RS22255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CVS48_RS22260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CVS48_RS22300	COG1902	pentaerythritol trinitrate reductase activity
CVS48_RS22305	COG1126	abc transporter atp-binding protein
CVS48_RS22310	COG0765	amino acid transport
CVS48_RS22315	COG0765	amino acid transport
CVS48_RS22320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS48_RS22330	COG1764	response to oxidative stress
CVS48_RS22335	COG1914	H( )-stimulated, divalent metal cation uptake system
CVS48_RS22350	COG2271	Major facilitator Superfamily
CVS48_RS22380	COG0506	proline dehydrogenase activity
CVS48_RS22380	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CVS48_RS22380	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CVS48_RS22390	COG3008	intermembrane lipid transfer
CVS48_RS22395	COG2995	paraquat-inducible protein a
CVS48_RS22400	COG0542	response to heat
CVS48_RS22405	COG4953	penicillin-binding protein 1C
CVS48_RS22410	COG2373	Large extracellular alpha-helical protein
CVS48_RS22415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CVS48_RS22420	COG1278	Cold shock
CVS48_RS22430	COG0183	Belongs to the thiolase family
CVS48_RS22435	COG0038	chloride channel
CVS48_RS22445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CVS48_RS22450	COG1570	exodeoxyribonuclease VII activity
CVS48_RS22455	COG0811	peptide transport
CVS48_RS22465	COG1663	tetraacyldisaccharide 4'-kinase activity
CVS48_RS22470	COG2835	tetraacyldisaccharide 4'-kinase activity
CVS48_RS22475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CVS48_RS22480	COG0563	adenylate kinase activity
CVS48_RS22490	COG0728	peptidoglycan biosynthetic process
CVS48_RS22500	COG0268	Binds directly to 16S ribosomal RNA
CVS48_RS22505	COG0583	DNA-binding transcription factor activity
CVS48_RS22525	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS22530	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CVS48_RS22535	COG2186	Transcriptional regulator
CVS48_RS22545	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS22555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS48_RS22585	COG3384	dioxygenase
CVS48_RS22590	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS22595	COG0179	Fumarylacetoacetate (FAA) hydrolase
CVS48_RS22605	COG3971	2-oxopent-4-enoate hydratase activity
CVS48_RS22615	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS22620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CVS48_RS22625	COG1562	ergosterol biosynthetic process
CVS48_RS22630	COG1562	ergosterol biosynthetic process
CVS48_RS22640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CVS48_RS22660	COG1477	protein flavinylation
CVS48_RS22675	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CVS48_RS22685	COG5564	TIM-barrel signal transduction protein
CVS48_RS22690	COG5441	Belongs to the UPF0261 family
CVS48_RS22705	COG0542	response to heat
CVS48_RS22715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVS48_RS22750	COG0494	nUDIX hydrolase
CVS48_RS22755	COG0443	Heat shock 70 kDa protein
CVS48_RS22775	COG3530	Putative quorum-sensing-regulated virulence factor
CVS48_RS22810	COG1522	sequence-specific DNA binding
CVS48_RS22815	COG0488	(ABC) transporter
CVS48_RS22840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS22850	COG0456	acetyltransferase
CVS48_RS22865	COG2951	lytic endotransglycosylase activity
CVS48_RS22885	COG0583	DNA-binding transcription factor activity
CVS48_RS22900	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS22905	COG1473	amidohydrolase
CVS48_RS22910	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CVS48_RS22925	COG3618	amidohydrolase
CVS48_RS22975	COG0444	Belongs to the ABC transporter superfamily
CVS48_RS22980	COG4608	Belongs to the ABC transporter superfamily
CVS48_RS22985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS22990	COG0601	transmembrane transport
CVS48_RS22995	COG0747	negative chemotaxis
CVS48_RS23005	COG2814	Major facilitator Superfamily
CVS48_RS23010	COG2207	Transcriptional regulator
CVS48_RS23010	COG3708	Transcriptional regulator
CVS48_RS23020	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_RS23035	COG4942	peptidase
CVS48_RS23050	COG2169	Transcriptional regulator
CVS48_RS23075	COG1272	protein, Hemolysin III
CVS48_RS23095	COG0842	Transport permease protein
CVS48_RS23100	COG1131	(ABC) transporter
CVS48_RS23110	COG4948	Mandelate Racemase Muconate Lactonizing
CVS48_RS23120	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS23130	COG2824	Alkylphosphonate utilization operon protein PhnA
CVS48_RS23145	COG0348	domain, Protein
CVS48_RS23165	COG3278	Belongs to the heme-copper respiratory oxidase family
CVS48_RS23185	COG0156	8-amino-7-oxononanoate synthase activity
CVS48_RS23195	COG4106	trans-aconitate 2-methyltransferase activity
CVS48_RS23195	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CVS48_RS23200	COG3609	addiction module antidote protein, CC2985 family
CVS48_RS23205	COG0583	DNA-binding transcription factor activity
CVS48_RS23210	COG1064	alcohol dehydrogenase
CVS48_RS23215	COG2224	Isocitrate lyase
CVS48_RS23220	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVS48_RS23220	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVS48_RS23225	COG1473	amidohydrolase
CVS48_RS23235	COG2814	Major facilitator Superfamily
CVS48_RS23240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CVS48_RS23255	COG0736	holo-[acyl-carrier-protein] synthase activity
CVS48_RS23260	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CVS48_RS23300	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CVS48_RS23305	COG4149	molybdate abc transporter
CVS48_RS23310	COG0725	ABC transporter, periplasmic molybdate-binding protein
CVS48_RS23315	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CVS48_RS23335	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CVS48_RS23355	COG4120	Belongs to the binding-protein-dependent transport system permease family
CVS48_RS23365	COG0667	Aldo Keto reductase
CVS48_RS23375	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS23380	COG1024	Enoyl-CoA hydratase
CVS48_RS23390	COG1802	Transcriptional regulator
CVS48_RS23405	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS23420	COG1024	Enoyl-CoA hydratase
CVS48_RS23430	COG0183	Belongs to the thiolase family
CVS48_RS23435	COG1024	Enoyl-CoA hydratase
CVS48_RS23440	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS23450	COG0583	DNA-binding transcription factor activity
CVS48_RS23455	COG0517	IMP dehydrogenase activity
CVS48_RS23520	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS23530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CVS48_RS23535	COG3384	dioxygenase
CVS48_RS23550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CVS48_RS23605	COG4964	Belongs to the GSP D family
CVS48_RS23650	COG1846	Transcriptional regulator
CVS48_RS23655	COG4172	Belongs to the ABC transporter superfamily
CVS48_RS23660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS23665	COG0601	transmembrane transport
CVS48_RS23680	COG0598	Magnesium transport protein CorA
CVS48_RS23700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CVS48_RS23710	COG0483	inositol monophosphate 1-phosphatase activity
CVS48_RS23715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CVS48_RS23720	COG1045	serine acetyltransferase
CVS48_RS23725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVS48_RS23730	COG0166	Belongs to the GPI family
CVS48_RS23755	COG1051	belongs to the nudix hydrolase family
CVS48_RS23775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS48_RS23805	COG0110	maltose O-acetyltransferase activity
CVS48_RS23810	COG0297	glycogen (starch) synthase activity
CVS48_RS23815	COG3415	Transposase
CVS48_RS23815	COG2801	Transposase and inactivated derivatives
CVS48_RS23820	COG2197	response regulator
CVS48_RS23825	COG2197	response regulator
CVS48_RS23845	COG0183	Belongs to the thiolase family
CVS48_RS23850	COG1024	Enoyl-CoA hydratase
CVS48_RS23850	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_RS23860	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_RS23860	COG1024	Enoyl-CoA hydratase
CVS48_RS23865	COG0183	Belongs to the thiolase family
CVS48_RS23880	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS23890	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS23900	COG4774	siderophore transport
CVS48_RS23910	COG3395	kinase activity
CVS48_RS23915	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CVS48_RS23935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS48_RS23940	COG1129	ABC transporter
CVS48_RS23940	COG0842	Transport permease protein
CVS48_RS23945	COG0842	Transport permease protein
CVS48_RS23950	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS23955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CVS48_RS23960	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CVS48_RS23975	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS23985	COG1414	Transcriptional regulator
CVS48_RS23995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CVS48_RS24025	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CVS48_RS24045	COG0825	malonyl-CoA metabolic process
CVS48_RS24055	COG0215	cysteine-tRNA ligase activity
CVS48_RS24070	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS48_RS24075	COG1968	undecaprenyl-diphosphatase activity
CVS48_RS24080	COG1253	flavin adenine dinucleotide binding
CVS48_RS24085	COG0483	inositol monophosphate 1-phosphatase activity
CVS48_RS24105	COG0668	transmembrane transport
CVS48_RS24135	COG0235	Class ii aldolase
CVS48_RS24150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS48_RS24155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_RS24175	COG1802	Transcriptional regulator
CVS48_RS24195	COG3360	Dodecin
CVS48_RS24205	COG0583	DNA-binding transcription factor activity
CVS48_RS24210	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS24490	COG0582	viral genome integration into host DNA
CVS48_RS24520	COG2916	Histone family protein nucleoid-structuring protein H-NS
CVS48_RS24605	COG1403	HNH endonuclease
CVS48_RS24660	COG2850	peptidyl-arginine hydroxylation
CVS48_RS24670	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CVS48_RS24675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_RS24680	COG1994	Peptidase M50
CVS48_RS24685	COG0009	L-threonylcarbamoyladenylate synthase
CVS48_RS24690	COG2321	neutral zinc metallopeptidase
CVS48_RS24745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS48_RS24855	COG3756	Protein conserved in bacteria
CVS48_RS24895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS48_RS24905	COG1024	Enoyl-CoA hydratase
CVS48_RS24935	COG1802	Transcriptional regulator
CVS48_RS24950	COG2197	response regulator
CVS48_RS24975	COG3121	Chaperone
CVS48_RS24980	COG3188	usher protein
CVS48_RS24995	COG2271	Major facilitator Superfamily
CVS48_RS25000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_RS25015	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS25020	COG0028	Belongs to the TPP enzyme family
CVS48_RS25025	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS25030	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS25045	COG1414	Transcriptional regulator
CVS48_RS25050	COG0583	DNA-binding transcription factor activity
CVS48_RS25060	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS25075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVS48_RS25080	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CVS48_RS25085	COG2080	2 iron, 2 sulfur cluster binding
CVS48_RS25110	COG1024	Enoyl-CoA hydratase
CVS48_RS25120	COG1228	amidohydrolase
CVS48_RS25135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_RS25145	COG1414	Transcriptional regulator
CVS48_RS25150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_RS25155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CVS48_RS25160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CVS48_RS25165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_RS25170	COG3485	protocatechuate 3,4-dioxygenase
CVS48_RS25175	COG3485	protocatechuate 3,4-dioxygenase
CVS48_RS25190	COG1278	Cold shock
CVS48_RS25215	COG2070	2-Nitropropane dioxygenase
CVS48_RS25225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS25240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_RS25245	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS25250	COG1024	Enoyl-CoA hydratase
CVS48_RS25305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_RS25310	COG0765	amino acid transport
CVS48_RS25330	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS25340	COG2423	ornithine cyclodeaminase activity
CVS48_RS25345	COG0601	transmembrane transport
CVS48_RS25350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS48_RS25355	COG0747	negative chemotaxis
CVS48_RS25360	COG0402	S-adenosylhomocysteine deaminase activity
CVS48_RS25365	COG4172	Belongs to the ABC transporter superfamily
CVS48_RS25375	COG0583	DNA-binding transcription factor activity
CVS48_RS25395	COG2197	response regulator
CVS48_RS25400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CVS48_RS25405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CVS48_RS25410	COG1116	anion transmembrane transporter activity
CVS48_RS25415	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CVS48_RS25435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS48_RS25505	COG1396	sequence-specific DNA binding
CVS48_RS25515	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS25540	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS25545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS25550	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CVS48_RS25565	COG0183	Belongs to the thiolase family
CVS48_RS25570	COG1024	Enoyl-CoA hydratase
CVS48_RS25570	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_RS25580	COG1063	alcohol dehydrogenase
CVS48_RS25600	COG0071	Belongs to the small heat shock protein (HSP20) family
CVS48_RS25635	COG4585	Histidine kinase
CVS48_RS25660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS48_RS25680	COG2192	nodulation
CVS48_RS25690	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CVS48_RS25695	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS25700	COG0438	transferase activity, transferring glycosyl groups
CVS48_RS25705	COG5265	(ABC) transporter
CVS48_RS25715	COG0463	Glycosyl transferase, family 2
CVS48_RS25740	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CVS48_RS25745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CVS48_RS25750	COG3546	catalase activity
CVS48_RS25790	COG2201	protein-glutamate methylesterase activity
CVS48_RS25810	COG0668	transmembrane transport
CVS48_RS25820	COG1058	Belongs to the CinA family
CVS48_RS25820	COG1546	Belongs to the CinA family
CVS48_RS25830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVS48_RS25835	COG3485	protocatechuate 3,4-dioxygenase
CVS48_RS25840	COG3485	protocatechuate 3,4-dioxygenase
CVS48_RS25850	COG2271	Major facilitator Superfamily
CVS48_RS25860	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS25875	COG0318	PFAM AMP-dependent synthetase and ligase
CVS48_RS25880	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS25885	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS25890	COG0183	Belongs to the thiolase family
CVS48_RS25900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS25920	COG4176	ABC-type proline glycine betaine transport system permease component
CVS48_RS25930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS48_RS25935	COG2814	Major facilitator Superfamily
CVS48_RS25940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CVS48_RS25945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CVS48_RS25975	COG1686	Belongs to the peptidase S11 family
CVS48_RS25985	COG1846	Transcriptional regulator
CVS48_RS25990	COG2814	Major facilitator Superfamily
CVS48_RS25995	COG0495	leucyl-tRNA aminoacylation
CVS48_RS26010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CVS48_RS26025	COG0154	amidase activity
CVS48_RS26035	COG0477	Major facilitator Superfamily
CVS48_RS26040	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS48_RS26055	COG0583	DNA-binding transcription factor activity
CVS48_RS26065	COG0235	Class ii aldolase
CVS48_RS26095	COG1530	ribonuclease E activity
CVS48_RS26105	COG2203	Gaf domain
CVS48_RS26105	COG3706	GGDEF domain
CVS48_RS26105	COG5001	Diguanylate cyclase
CVS48_RS26105	COG4251	negative regulation of phosphorylation
CVS48_RS26115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CVS48_RS26115	COG0475	glutathione-regulated potassium exporter activity
CVS48_RS26120	COG1132	(ABC) transporter
CVS48_RS26145	COG0726	polysaccharide deacetylase
CVS48_RS26150	COG0438	transferase activity, transferring glycosyl groups
CVS48_RS26160	COG0726	polysaccharide deacetylase
CVS48_RS26165	COG0438	transferase activity, transferring glycosyl groups
CVS48_RS26180	COG1643	Atp-dependent helicase
CVS48_RS26185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVS48_RS26185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CVS48_RS26190	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CVS48_RS26200	COG0704	Plays a role in the regulation of phosphate uptake
CVS48_RS26205	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CVS48_RS26210	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS26230	COG2094	Belongs to the DNA glycosylase MPG family
CVS48_RS26240	COG1177	transmembrane transport
CVS48_RS26245	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS48_RS26250	COG3842	ATPase activity
CVS48_RS26255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CVS48_RS26260	COG3642	lipopolysaccharide core region biosynthetic process
CVS48_RS26270	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CVS48_RS26275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CVS48_RS26285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CVS48_RS26285	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CVS48_RS26290	COG4608	Belongs to the ABC transporter superfamily
CVS48_RS26295	COG0444	Belongs to the ABC transporter superfamily
CVS48_RS26315	COG0601	transmembrane transport
CVS48_RS26320	COG0747	negative chemotaxis
CVS48_RS26340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVS48_RS26345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CVS48_RS26375	COG0583	DNA-binding transcription factor activity
CVS48_RS26380	COG0137	argininosuccinate synthase activity
CVS48_RS26385	COG3158	transport of potassium into the cell
CVS48_RS26390	COG0642	Histidine kinase
CVS48_RS26420	COG0776	regulation of translation
CVS48_RS26425	COG3128	pkhd-type hydroxylase
CVS48_RS26430	COG0626	cystathionine gamma-synthase activity
CVS48_RS26435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVS48_RS26440	COG0557	exoribonuclease II activity
CVS48_RS26480	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CVS48_RS26485	COG2391	methyltransferase activity
CVS48_RS26490	COG0069	glutamate synthase activity
CVS48_RS26495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS48_RS26505	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CVS48_RS26510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CVS48_RS26540	COG0697	spore germination
CVS48_RS26585	COG3909	cytochrome
CVS48_RS26595	COG0625	glutathione transferase activity
CVS48_RS26600	COG0730	response to heat
CVS48_RS26605	COG0482	sulfurtransferase activity
CVS48_RS26610	COG0583	DNA-binding transcription factor activity
CVS48_RS26640	COG0247	lactate metabolic process
CVS48_RS26645	COG0277	FAD linked oxidase domain protein
CVS48_RS26650	COG0277	FAD linked oxidase domain protein
CVS48_RS26655	COG0277	FAD linked oxidase domain protein
CVS48_RS26660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS48_RS26665	COG0312	modulator of DNA gyrase
CVS48_RS26680	COG0308	aminopeptidase N
CVS48_RS26685	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CVS48_RS26705	COG0436	Aminotransferase
CVS48_RS26715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CVS48_RS26720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CVS48_RS26740	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS48_RS26770	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS26780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CVS48_RS26800	COG0181	hydroxymethylbilane synthase activity
CVS48_RS26805	COG0861	Integral membrane protein TerC family
CVS48_RS26810	COG0861	Integral membrane protein TerC family
CVS48_RS26815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CVS48_RS26820	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS48_RS26830	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CVS48_RS26840	COG2137	regulation of response to DNA damage stimulus
CVS48_RS26845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CVS48_RS26880	COG0540	Belongs to the ATCase OTCase family
CVS48_RS26910	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CVS48_RS26930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS48_RS26965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CVS48_RS26975	COG0305	Participates in initiation and elongation during chromosome replication
CVS48_RS26985	COG0359	binds to the 23S rRNA
CVS48_RS26990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CVS48_RS26995	COG2965	DNA replication, synthesis of RNA primer
CVS48_RS27000	COG0360	Binds together with S18 to 16S ribosomal RNA
CVS48_RS27005	COG3739	integral membrane protein
CVS48_RS27010	COG1469	GTP cyclohydrolase I activity
CVS48_RS27020	COG0142	geranyltranstransferase activity
CVS48_RS27025	COG1722	exodeoxyribonuclease VII activity
CVS48_RS27035	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS27050	COG0492	ferredoxin-NADP+ reductase activity
CVS48_RS27060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS48_RS27070	COG3842	ATPase activity
CVS48_RS27095	COG0501	Belongs to the peptidase M48B family
CVS48_RS27100	COG1760	l-serine dehydratase
CVS48_RS27105	COG1283	sodium-dependent phosphate transmembrane transporter activity
CVS48_RS27110	COG0412	Dienelactone hydrolase
CVS48_RS27115	COG0428	transporter
CVS48_RS27125	COG1611	Belongs to the LOG family
CVS48_RS27135	COG0583	DNA-binding transcription factor activity
CVS48_RS27145	COG1217	gtp-binding protein TYPA
CVS48_RS27150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CVS48_RS27155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CVS48_RS27160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CVS48_RS27165	COG2251	uridine kinase activity
CVS48_RS27165	COG0195	Participates in both transcription termination and antitermination
CVS48_RS27170	COG0779	Required for maturation of 30S ribosomal subunits
CVS48_RS27175	COG1187	pseudouridine synthase activity
CVS48_RS27180	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CVS48_RS27190	COG0583	DNA-binding transcription factor activity
CVS48_RS27195	COG0523	cobalamin synthesis protein
CVS48_RS27215	COG0642	Histidine kinase
CVS48_RS27220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS48_RS27225	COG0625	glutathione transferase activity
CVS48_RS27230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CVS48_RS27235	COG0544	peptidyl-prolyl cis-trans isomerase activity
CVS48_RS27240	COG2003	Belongs to the UPF0758 family
CVS48_RS27245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CVS48_RS27250	COG3483	tryptophan 2,3-dioxygenase activity
CVS48_RS27255	COG0254	rRNA binding
CVS48_RS27265	COG0534	Mate efflux family protein
CVS48_RS27275	COG2050	protein possibly involved in aromatic compounds catabolism
CVS48_RS27280	COG1024	Enoyl-CoA hydratase
CVS48_RS27285	COG1012	belongs to the aldehyde dehydrogenase family
CVS48_RS27290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS48_RS27295	COG2151	metal-sulfur cluster biosynthetic enzyme
CVS48_RS27300	COG3396	Phenylacetate-CoA oxygenase
CVS48_RS27305	COG3460	Phenylacetate-CoA oxygenase
CVS48_RS27310	COG3396	Phenylacetate-CoA oxygenase
CVS48_RS27315	COG3327	negative regulation of DNA-templated transcription, initiation
CVS48_RS27320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CVS48_RS27325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CVS48_RS27330	COG0501	Belongs to the peptidase M48B family
CVS48_RS27335	COG1162	GTPase activity
CVS48_RS27350	COG0335	large ribosomal subunit rRNA binding
CVS48_RS27370	COG2895	sulfate adenylyltransferase (ATP) activity
CVS48_RS27380	COG0175	sulfate reduction
CVS48_RS27385	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CVS48_RS27390	COG4208	sulfate ABC transporter
CVS48_RS27405	COG0450	alkyl hydroperoxide reductase
CVS48_RS27410	COG1960	acyl-CoA dehydrogenase activity
CVS48_RS27415	COG2985	domain, Protein
CVS48_RS27440	COG0123	including yeast histone deacetylase and acetoin utilization protein
CVS48_RS27445	COG2951	lytic endotransglycosylase activity
CVS48_RS27470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS48_RS27475	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CVS48_RS27480	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CVS48_RS27500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CVS48_RS27505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CVS48_RS27510	COG0287	Prephenate dehydrogenase
CVS48_RS27515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVS48_RS27525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CVS48_RS27540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVS48_RS27560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CVS48_RS27570	COG1215	transferase activity, transferring glycosyl groups
CVS48_RS27590	COG2951	lytic endotransglycosylase activity
CVS48_RS27595	COG2258	MOSC domain
CVS48_RS27600	COG2833	Protein of unknown function (DUF455)
CVS48_RS27615	COG1132	(ABC) transporter
CVS48_RS27620	COG0189	ligase activity
CVS48_RS27620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVS48_RS27625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVS48_RS27625	COG0189	ligase activity
CVS48_RS27630	COG3237	CsbD-like
CVS48_RS27655	COG0672	)-iron permease
CVS48_RS27670	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CVS48_RS27675	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS27680	COG3243	poly(R)-hydroxyalkanoic acid synthase
CVS48_RS27685	COG1496	oxidoreductase activity
CVS48_RS27690	COG0564	pseudouridine synthase activity
CVS48_RS27700	COG1199	ATP-dependent helicase activity
CVS48_RS27705	COG2183	response to ionizing radiation
CVS48_RS27740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS48_RS27750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS48_RS27760	COG0483	inositol monophosphate 1-phosphatase activity
CVS48_RS27775	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS48_RS27780	COG4774	siderophore transport
CVS48_RS27785	COG3712	iron ion homeostasis
CVS48_RS27790	COG1595	DNA-templated transcription, initiation
CVS48_RS27795	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CVS48_RS27800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS48_RS27805	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS48_RS27810	COG0567	Dehydrogenase, E1 component
CVS48_RS27815	COG1522	sequence-specific DNA binding
CVS48_RS27820	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CVS48_RS27845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS48_RS27850	COG2233	PERMEase
CVS48_RS27855	COG1297	OPT oligopeptide transporter protein
CVS48_RS27865	COG0280	phosphate acetyltransferase
CVS48_RS27865	COG0281	malic enzyme
CVS48_RS27885	COG0372	Belongs to the citrate synthase family
CVS48_RS27890	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CVS48_RS27895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CVS48_RS27900	COG1053	succinate dehydrogenase
CVS48_RS27905	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CVS48_RS27910	COG2009	succinate dehydrogenase
CVS48_RS27915	COG2188	Transcriptional regulator
CVS48_RS27920	COG0039	L-malate dehydrogenase activity
CVS48_RS27935	COG2079	MmgE PrpD family protein
CVS48_RS27940	COG1981	membrane
CVS48_RS27975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CVS48_RS27985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CVS48_RS27990	COG0148	phosphopyruvate hydratase activity
CVS48_RS28005	COG0504	CTP synthase activity
CVS48_RS28015	COG2801	Transposase and inactivated derivatives
CVS48_RS28015	COG3415	Transposase
CVS48_RS28040	COG0601	transmembrane transport
CVS48_RS28045	COG0747	negative chemotaxis
CVS48_RS28050	COG4172	Belongs to the ABC transporter superfamily
CVS48_RS28055	COG1446	asparaginase
CVS48_RS28065	COG2153	protein acetylation
CVS48_RS28130	COG1802	Transcriptional regulator
CVS48_RS28135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVS48_RS28140	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CVS48_RS28145	COG0697	spore germination
CVS48_RS28150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS48_RS28160	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CVS48_RS28165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS48_RS28170	COG0791	NLP P60 protein
CVS48_RS28180	COG0583	DNA-binding transcription factor activity
CVS48_RS28205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CVS48_RS28225	COG0667	Aldo Keto reductase
CVS48_RS28235	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS28245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CVS48_RS28255	COG1381	Involved in DNA repair and RecF pathway recombination
CVS48_RS28260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CVS48_RS28265	COG0571	ribonuclease III activity
CVS48_RS28270	COG0681	Belongs to the peptidase S26 family
CVS48_RS28280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS48_RS28305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS48_RS28310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVS48_RS28320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CVS48_RS28325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVS48_RS28330	COG0416	fatty acid biosynthetic process
CVS48_RS28335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CVS48_RS28340	COG1399	metal-binding, possibly nucleic acid-binding protein
CVS48_RS28345	COG0424	maF-like protein
CVS48_RS28355	COG3023	N-Acetylmuramoyl-L-alanine amidase
CVS48_RS28360	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CVS48_RS28365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CVS48_RS28380	COG1530	ribonuclease E activity
CVS48_RS28385	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CVS48_RS28390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CVS48_RS28395	COG0159	tryptophan synthase activity
CVS48_RS28405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS48_RS28415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVS48_RS28420	COG3228	Belongs to the MtfA family
CVS48_RS28430	COG0251	oxidation-reduction process
CVS48_RS28440	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CVS48_RS28455	COG2878	Part of a membrane complex involved in electron transport
CVS48_RS28460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CVS48_RS28495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CVS48_RS28520	COG1268	BioY protein
CVS48_RS28525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CVS48_RS28530	COG1122	ATPase activity
CVS48_RS28535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS48_RS28540	COG2917	probably involved in intracellular septation
CVS48_RS28550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS48_RS28555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CVS48_RS28565	COG1196	nuclear chromosome segregation
CVS48_RS28570	COG0477	Major facilitator Superfamily
CVS48_RS28575	COG1573	uracil-dna glycosylase
CVS48_RS28580	COG1214	PFAM Peptidase M22, glycoprotease
CVS48_RS28595	COG0450	alkyl hydroperoxide reductase
CVS48_RS28600	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS48_RS28610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CVS48_RS28615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CVS48_RS28620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CVS48_RS28625	COG0560	Phosphoserine phosphatase
CVS48_RS28630	COG4774	siderophore transport
CVS48_RS28640	COG1007	ATP synthesis coupled electron transport
CVS48_RS28655	COG0713	ATP synthesis coupled electron transport
CVS48_RS28665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS48_RS28670	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CVS48_RS28675	COG1034	ATP synthesis coupled electron transport
CVS48_RS28685	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CVS48_RS28690	COG0649	NAD binding
CVS48_RS28695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS48_RS28700	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS48_RS28705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS48_RS28710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CVS48_RS28735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CVS48_RS28755	COG0583	DNA-binding transcription factor activity
CVS48_RS28770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS48_RS28775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS48_RS28780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CVS48_RS28790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS48_RS28795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS48_RS28810	COG4166	transmembrane transport
CVS48_RS28815	COG4166	transmembrane transport
CVS48_RS28825	COG4172	Belongs to the ABC transporter superfamily
CVS48_RS28845	COG2354	Protein conserved in bacteria
CVS48_RS28855	COG1278	Cold shock
CVS48_RS28880	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS28885	COG2851	Citrate transporter
CVS48_RS28915	COG3181	Tripartite tricarboxylate transporter family receptor
CVS48_RS28960	COG2199	diguanylate cyclase activity
CVS48_RS28960	COG2203	Gaf domain
CVS48_RS28990	COG2365	Tyrosine phosphatase family
CVS48_RS29020	COG1595	DNA-templated transcription, initiation
CVS48_RS29025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CVS48_RS29030	COG0149	triose-phosphate isomerase activity
CVS48_RS29035	COG3321	synthase
CVS48_RS29035	COG0604	alcohol dehydrogenase
CVS48_RS29035	COG1028	Short-chain dehydrogenase reductase Sdr
CVS48_RS29045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS48_RS29055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CVS48_RS29090	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS48_RS29100	COG1185	polyribonucleotide nucleotidyltransferase activity
CVS48_RS29105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CVS48_RS29115	COG1183	phosphatidylcholine synthase activity
CVS48_RS29120	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CVS48_RS29125	COG0440	acetolactate synthase activity