locus-tag	class	description
N8Z00_RS00045	COG1522	sequence-specific DNA binding
N8Z00_RS00055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N8Z00_RS00060	COG4654	Cytochrome c, class I
N8Z00_RS00065	COG0129	dihydroxy-acid dehydratase activity
N8Z00_RS00105	COG2084	Dehydrogenase
N8Z00_RS00120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N8Z00_RS00155	COG0824	Thioesterase
N8Z00_RS00160	COG0811	peptide transport
N8Z00_RS00165	COG0848	biopolymer transport protein
N8Z00_RS00175	COG0823	Involved in the tonB-independent uptake of proteins
N8Z00_RS00190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N8Z00_RS00195	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N8Z00_RS00210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N8Z00_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8Z00_RS00230	COG0697	spore germination
N8Z00_RS00250	COG0583	DNA-binding transcription factor activity
N8Z00_RS00265	COG0463	Glycosyl transferase, family 2
N8Z00_RS00275	COG0786	glutamate:sodium symporter activity
N8Z00_RS00290	COG1671	Belongs to the UPF0178 family
N8Z00_RS00305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N8Z00_RS00310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N8Z00_RS00320	COG0328	RNA-DNA hybrid ribonuclease activity
N8Z00_RS00325	COG2226	methyltransferase
N8Z00_RS00330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8Z00_RS00335	COG1388	LysM domain
N8Z00_RS00335	COG0741	lytic transglycosylase activity
N8Z00_RS00355	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS00380	COG3188	usher protein
N8Z00_RS00415	COG2719	SpoVR family
N8Z00_RS00420	COG2718	Belongs to the UPF0229 family
N8Z00_RS00425	COG2766	serine protein kinase
N8Z00_RS00430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N8Z00_RS00430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N8Z00_RS00445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N8Z00_RS00450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N8Z00_RS00455	COG1881	PFAM PEBP family protein
N8Z00_RS00460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N8Z00_RS00475	COG0316	Belongs to the HesB IscA family
N8Z00_RS00485	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N8Z00_RS00490	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N8Z00_RS00495	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N8Z00_RS00510	COG4177	L-phenylalanine transmembrane transporter activity
N8Z00_RS00515	COG0559	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS00525	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N8Z00_RS00530	COG0312	modulator of DNA gyrase
N8Z00_RS00535	COG3028	Belongs to the UPF0307 family
N8Z00_RS00550	COG1116	anion transmembrane transporter activity
N8Z00_RS00555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8Z00_RS00560	COG1335	isochorismatase
N8Z00_RS00565	COG1042	CoA-binding domain protein
N8Z00_RS00565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N8Z00_RS00565	COG0045	succinate-CoA ligase (ADP-forming) activity
N8Z00_RS00570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N8Z00_RS00575	COG2814	Major facilitator Superfamily
N8Z00_RS00585	COG1522	sequence-specific DNA binding
N8Z00_RS00595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N8Z00_RS00595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N8Z00_RS00620	COG1696	Membrane protein involved in D-alanine export
N8Z00_RS00645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N8Z00_RS00645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N8Z00_RS00655	COG2264	protein methyltransferase activity
N8Z00_RS00660	COG0439	Biotin carboxylase
N8Z00_RS00665	COG0511	ligase activity, forming carbon-carbon bonds
N8Z00_RS00670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N8Z00_RS00675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N8Z00_RS00680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N8Z00_RS00685	COG3150	esterase
N8Z00_RS00690	COG0557	exoribonuclease II activity
N8Z00_RS00710	COG1175	transmembrane transport
N8Z00_RS00725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N8Z00_RS00730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N8Z00_RS00740	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N8Z00_RS00745	COG1126	abc transporter atp-binding protein
N8Z00_RS00750	COG0765	amino acid transport
N8Z00_RS00760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS00765	COG0436	Aminotransferase
N8Z00_RS00770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N8Z00_RS00785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N8Z00_RS00795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N8Z00_RS00800	COG1678	Uncharacterized ACR, COG1678
N8Z00_RS00815	COG0352	thiamine-phosphate diphosphorylase activity
N8Z00_RS00820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N8Z00_RS00825	COG0741	lytic transglycosylase activity
N8Z00_RS00835	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS00840	COG1335	isochorismatase
N8Z00_RS00845	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
N8Z00_RS00850	COG4638	Rieske (2fe-2S)
N8Z00_RS00865	COG2207	Transcriptional regulator
N8Z00_RS00890	COG1024	Enoyl-CoA hydratase
N8Z00_RS00895	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS00965	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N8Z00_RS00985	COG3842	ATPase activity
N8Z00_RS00990	COG1175	transmembrane transport
N8Z00_RS00995	COG3833	ABC-type maltose transport systems, permease component
N8Z00_RS01010	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
N8Z00_RS01015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8Z00_RS01030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N8Z00_RS01045	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
N8Z00_RS01050	COG0237	dephospho-CoA kinase activity
N8Z00_RS01070	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N8Z00_RS01075	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N8Z00_RS01085	COG0477	Major facilitator Superfamily
N8Z00_RS01100	COG1194	a g-specific adenine glycosylase
N8Z00_RS01110	COG2226	methyltransferase
N8Z00_RS01115	COG0246	Mannitol dehydrogenase
N8Z00_RS01120	COG4948	Mandelate Racemase Muconate Lactonizing
N8Z00_RS01125	COG1063	alcohol dehydrogenase
N8Z00_RS01130	COG2186	Transcriptional regulator
N8Z00_RS01145	COG4771	TonB-dependent receptor
N8Z00_RS01150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N8Z00_RS01155	COG2022	thiamine diphosphate biosynthetic process
N8Z00_RS01160	COG0351	phosphomethylpyrimidine kinase
N8Z00_RS01165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N8Z00_RS01175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N8Z00_RS01185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N8Z00_RS01200	COG2226	methyltransferase
N8Z00_RS01205	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS01220	COG0642	Histidine kinase
N8Z00_RS01225	COG2132	Multicopper oxidase
N8Z00_RS01240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N8Z00_RS01245	COG0583	DNA-binding transcription factor activity
N8Z00_RS01255	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N8Z00_RS01260	COG1984	allophanate hydrolase subunit 2
N8Z00_RS01265	COG1802	Transcriptional regulator
N8Z00_RS01270	COG2860	membrane
N8Z00_RS01280	COG2223	nitrite transmembrane transporter activity
N8Z00_RS01285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N8Z00_RS01285	COG2813	Specifically methylates the guanine in position
N8Z00_RS01290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N8Z00_RS01295	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N8Z00_RS01305	COG2197	response regulator
N8Z00_RS01320	COG2918	glutathione biosynthetic process
N8Z00_RS01340	COG0583	DNA-binding transcription factor activity
N8Z00_RS01345	COG0657	acetylesterase activity
N8Z00_RS01350	COG1802	Transcriptional regulator
N8Z00_RS01360	COG1129	ABC transporter
N8Z00_RS01380	COG0179	Fumarylacetoacetate (FAA) hydrolase
N8Z00_RS01405	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS01410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS01420	COG1309	transcriptional regulator
N8Z00_RS01430	COG1024	Enoyl-CoA hydratase
N8Z00_RS01435	COG1024	Enoyl-CoA hydratase
N8Z00_RS01440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N8Z00_RS01450	COG0747	negative chemotaxis
N8Z00_RS01455	COG2988	succinylglutamate desuccinylase activity
N8Z00_RS01460	COG0747	negative chemotaxis
N8Z00_RS01465	COG0601	transmembrane transport
N8Z00_RS01475	COG0444	Belongs to the ABC transporter superfamily
N8Z00_RS01480	COG4608	Belongs to the ABC transporter superfamily
N8Z00_RS01490	COG2195	Cleaves the N-terminal amino acid of tripeptides
N8Z00_RS01495	COG2171	N-acyltransferase activity
N8Z00_RS01505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N8Z00_RS01520	COG0210	DNA helicase
N8Z00_RS01525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N8Z00_RS01530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N8Z00_RS01540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N8Z00_RS01550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N8Z00_RS01555	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N8Z00_RS01560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N8Z00_RS01575	COG0356	it plays a direct role in the translocation of protons across the membrane
N8Z00_RS01595	COG1024	Enoyl-CoA hydratase
N8Z00_RS01600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N8Z00_RS01610	COG3188	usher protein
N8Z00_RS01615	COG3121	Chaperone
N8Z00_RS01630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N8Z00_RS01655	COG0037	tRNA processing
N8Z00_RS01660	COG0596	Alpha beta hydrolase
N8Z00_RS01665	COG0583	DNA-binding transcription factor activity
N8Z00_RS01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N8Z00_RS01680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8Z00_RS01685	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N8Z00_RS01690	COG2967	ApaG domain
N8Z00_RS01695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N8Z00_RS01700	COG0546	phosphoglycolate phosphatase activity
N8Z00_RS01710	COG0512	Glutamine amidotransferase of anthranilate synthase
N8Z00_RS01715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N8Z00_RS01720	COG0134	indole-3-glycerol-phosphate synthase activity
N8Z00_RS01725	COG3284	Transcriptional regulator
N8Z00_RS01730	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS01750	COG0583	DNA-binding transcription factor activity
N8Z00_RS01760	COG1305	Transglutaminase-like
N8Z00_RS01770	COG3276	selenocysteine insertion sequence binding
N8Z00_RS01775	COG1921	L-seryl-tRNASec selenium transferase activity
N8Z00_RS01785	COG2864	formate dehydrogenase
N8Z00_RS01790	COG0437	4 iron, 4 sulfur cluster binding
N8Z00_RS01805	COG1607	acyl-coa hydrolase
N8Z00_RS01830	COG3064	Membrane
N8Z00_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS01855	COG3069	C4-dicarboxylate transmembrane transporter activity
N8Z00_RS01865	COG1802	Transcriptional regulator
N8Z00_RS01905	COG2814	Major facilitator Superfamily
N8Z00_RS01910	COG0840	transmembrane signaling receptor activity
N8Z00_RS01915	COG1228	amidohydrolase
N8Z00_RS01930	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N8Z00_RS01935	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N8Z00_RS01960	COG0737	Belongs to the 5'-nucleotidase family
N8Z00_RS01980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N8Z00_RS01985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N8Z00_RS01990	COG5001	Diguanylate cyclase
N8Z00_RS02000	COG2423	ornithine cyclodeaminase activity
N8Z00_RS02005	COG1522	sequence-specific DNA binding
N8Z00_RS02045	COG1595	DNA-templated transcription, initiation
N8Z00_RS02050	COG3300	MHYT domain
N8Z00_RS02050	COG5001	Diguanylate cyclase
N8Z00_RS02055	COG0583	DNA-binding transcription factor activity
N8Z00_RS02060	COG2814	Major facilitator Superfamily
N8Z00_RS02070	COG0583	DNA-binding transcription factor activity
N8Z00_RS02075	COG0656	L-ascorbic acid biosynthetic process
N8Z00_RS02080	COG0154	amidase activity
N8Z00_RS02085	COG4608	Belongs to the ABC transporter superfamily
N8Z00_RS02090	COG0444	Belongs to the ABC transporter superfamily
N8Z00_RS02095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS02100	COG0601	transmembrane transport
N8Z00_RS02105	COG0747	negative chemotaxis
N8Z00_RS02115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8Z00_RS02125	COG0243	molybdopterin cofactor binding
N8Z00_RS02160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N8Z00_RS02170	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8Z00_RS02195	COG0583	DNA-binding transcription factor activity
N8Z00_RS02200	COG1454	alcohol dehydrogenase
N8Z00_RS02250	COG3866	Pectate lyase
N8Z00_RS02255	COG4783	chaperone-mediated protein folding
N8Z00_RS02255	COG1560	Kdo2-lipid A biosynthetic process
N8Z00_RS02280	COG0438	transferase activity, transferring glycosyl groups
N8Z00_RS02285	COG0457	Tetratricopeptide repeat
N8Z00_RS02310	COG0251	oxidation-reduction process
N8Z00_RS02315	COG0583	DNA-binding transcription factor activity
N8Z00_RS02320	COG4221	oxidoreductase activity
N8Z00_RS02325	COG2207	Transcriptional regulator
N8Z00_RS02365	COG0784	Response regulator, receiver
N8Z00_RS02365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS02365	COG2198	Histidine kinase
N8Z00_RS02365	COG2205	protein histidine kinase activity
N8Z00_RS02370	COG3437	response regulator, receiver
N8Z00_RS02375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8Z00_RS02395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N8Z00_RS02405	COG1538	Outer membrane efflux protein
N8Z00_RS02415	COG0628	permease
N8Z00_RS02440	COG0471	metal ion transport
N8Z00_RS02440	COG0490	domain, Protein
N8Z00_RS02455	COG3550	peptidyl-serine autophosphorylation
N8Z00_RS02515	COG2814	Major facilitator Superfamily
N8Z00_RS02520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N8Z00_RS02540	COG1999	signal sequence binding
N8Z00_RS02550	COG1612	heme a metabolic process
N8Z00_RS02585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N8Z00_RS02605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N8Z00_RS02630	COG0067	glutamate synthase
N8Z00_RS02630	COG0069	glutamate synthase activity
N8Z00_RS02630	COG0070	glutamate synthase
N8Z00_RS02645	COG0583	DNA-binding transcription factor activity
N8Z00_RS02650	COG0477	Major facilitator Superfamily
N8Z00_RS02660	COG2070	2-Nitropropane dioxygenase
N8Z00_RS02665	COG1127	ABC transporter
N8Z00_RS02670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N8Z00_RS02675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N8Z00_RS02680	COG2853	Lipoprotein
N8Z00_RS02690	COG1131	(ABC) transporter
N8Z00_RS02695	COG0842	Transport permease protein
N8Z00_RS02700	COG5007	Belongs to the BolA IbaG family
N8Z00_RS02705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N8Z00_RS02710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N8Z00_RS02715	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N8Z00_RS02720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N8Z00_RS02725	COG0131	Imidazoleglycerol-phosphate dehydratase
N8Z00_RS02730	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N8Z00_RS02735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N8Z00_RS02740	COG0107	imidazoleglycerol-phosphate synthase activity
N8Z00_RS02745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N8Z00_RS02750	COG0140	phosphoribosyl-ATP diphosphatase activity
N8Z00_RS02755	COG0537	adenosine 5'-monophosphoramidase activity
N8Z00_RS02760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N8Z00_RS02765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N8Z00_RS02770	COG0805	protein transport
N8Z00_RS02780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N8Z00_RS02785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N8Z00_RS02790	COG1970	mechanosensitive ion channel activity
N8Z00_RS02795	COG0723	plastoquinol--plastocyanin reductase activity
N8Z00_RS02800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N8Z00_RS02805	COG2857	Cytochrome c1
N8Z00_RS02810	COG0625	glutathione transferase activity
N8Z00_RS02815	COG2969	positive regulation of protein catabolic process
N8Z00_RS02820	COG3718	enzyme involved in inositol metabolism
N8Z00_RS02830	COG3962	Belongs to the TPP enzyme family
N8Z00_RS02845	COG1172	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS02855	COG1737	Transcriptional regulator
N8Z00_RS02860	COG0673	inositol 2-dehydrogenase activity
N8Z00_RS02865	COG0673	inositol 2-dehydrogenase activity
N8Z00_RS02890	COG0583	DNA-binding transcription factor activity
N8Z00_RS02910	COG2207	Transcriptional regulator
N8Z00_RS02910	COG3708	Transcriptional regulator
N8Z00_RS02920	COG1160	GTP binding
N8Z00_RS02925	COG0747	negative chemotaxis
N8Z00_RS02930	COG0601	transmembrane transport
N8Z00_RS02935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS02950	COG5339	Protein conserved in bacteria
N8Z00_RS02955	COG5339	Protein conserved in bacteria
N8Z00_RS02960	COG0513	Belongs to the DEAD box helicase family
N8Z00_RS02965	COG1280	lysine exporter protein (LysE YggA)
N8Z00_RS02970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N8Z00_RS02990	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
N8Z00_RS03000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N8Z00_RS03010	COG1609	Transcriptional regulator
N8Z00_RS03015	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N8Z00_RS03020	COG3842	ATPase activity
N8Z00_RS03025	COG1653	transport
N8Z00_RS03030	COG1175	transmembrane transport
N8Z00_RS03035	COG0395	ABC-type sugar transport system, permease component
N8Z00_RS03060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N8Z00_RS03080	COG0778	Nitroreductase
N8Z00_RS03085	COG1280	lysine exporter protein (LysE YggA)
N8Z00_RS03105	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS03110	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
N8Z00_RS03115	COG0183	Belongs to the thiolase family
N8Z00_RS03120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N8Z00_RS03140	COG0693	protein deglycase activity
N8Z00_RS03165	COG3852	Histidine kinase
N8Z00_RS03190	COG0346	lactoylglutathione lyase activity
N8Z00_RS03200	COG0668	transmembrane transport
N8Z00_RS03220	COG0300	oxidoreductase activity
N8Z00_RS03225	COG2207	Transcriptional regulator
N8Z00_RS03240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N8Z00_RS03250	COG0477	Major facilitator Superfamily
N8Z00_RS03255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS03260	COG0765	amino acid transport
N8Z00_RS03265	COG0765	amino acid transport
N8Z00_RS03280	COG2358	TRAP transporter, solute receptor (TAXI family
N8Z00_RS03290	COG2922	Belongs to the Smg family
N8Z00_RS03295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N8Z00_RS03305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N8Z00_RS03305	COG0551	DNA topoisomerase type I activity
N8Z00_RS03315	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
N8Z00_RS03320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8Z00_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS03330	COG0028	Belongs to the TPP enzyme family
N8Z00_RS03335	COG1522	sequence-specific DNA binding
N8Z00_RS03340	COG3781	membrane
N8Z00_RS03370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N8Z00_RS03375	COG2910	NAD(P)H-binding
N8Z00_RS03380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N8Z00_RS03395	COG3845	ABC transporter
N8Z00_RS03400	COG4603	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS03410	COG0402	S-adenosylhomocysteine deaminase activity
N8Z00_RS03415	COG0251	oxidation-reduction process
N8Z00_RS03440	COG1177	transmembrane transport
N8Z00_RS03445	COG1176	ABC-type spermidine putrescine transport system, permease component I
N8Z00_RS03450	COG3842	ATPase activity
N8Z00_RS03460	COG2188	Transcriptional regulator
N8Z00_RS03475	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS03515	COG1177	transmembrane transport
N8Z00_RS03520	COG1176	ABC-type spermidine putrescine transport system, permease component I
N8Z00_RS03525	COG3842	ATPase activity
N8Z00_RS03560	COG1126	abc transporter atp-binding protein
N8Z00_RS03565	COG0765	amino acid transport
N8Z00_RS03570	COG0765	amino acid transport
N8Z00_RS03580	COG0583	DNA-binding transcription factor activity
N8Z00_RS03600	COG0592	DNA-directed DNA polymerase activity
N8Z00_RS03605	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N8Z00_RS03610	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N8Z00_RS03615	COG0594	ribonuclease P activity
N8Z00_RS03620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N8Z00_RS03630	COG0753	catalase activity
N8Z00_RS03640	COG1473	amidohydrolase
N8Z00_RS03645	COG4608	Belongs to the ABC transporter superfamily
N8Z00_RS03650	COG0444	Belongs to the ABC transporter superfamily
N8Z00_RS03655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS03660	COG0601	transmembrane transport
N8Z00_RS03670	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N8Z00_RS03680	COG0454	-acetyltransferase
N8Z00_RS03680	COG0456	acetyltransferase
N8Z00_RS03685	COG0038	chloride channel
N8Z00_RS03695	COG5002	protein histidine kinase activity
N8Z00_RS03695	COG3850	Histidine kinase
N8Z00_RS03715	COG0436	Aminotransferase
N8Z00_RS03720	COG3180	Ammonia monooxygenase
N8Z00_RS03725	COG1278	Cold shock
N8Z00_RS03730	COG0445	tRNA wobble uridine modification
N8Z00_RS03735	COG0357	Ribosomal RNA small subunit methyltransferase G
N8Z00_RS03740	COG1192	Involved in chromosome partitioning
N8Z00_RS03750	COG1475	DNA binding
N8Z00_RS03755	COG0252	asparaginase activity
N8Z00_RS03760	COG0583	DNA-binding transcription factor activity
N8Z00_RS03815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N8Z00_RS03835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N8Z00_RS03840	COG0081	regulation of translation
N8Z00_RS03845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N8Z00_RS03850	COG0222	ribosome binding
N8Z00_RS03855	COG0085	RNA polymerase activity
N8Z00_RS03860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N8Z00_RS03875	COG5002	protein histidine kinase activity
N8Z00_RS03890	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS03895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N8Z00_RS03900	COG0049	tRNA binding
N8Z00_RS03905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N8Z00_RS03910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N8Z00_RS03915	COG0051	transcription antitermination factor activity, RNA binding
N8Z00_RS03920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N8Z00_RS03930	COG0089	rRNA binding
N8Z00_RS03935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N8Z00_RS03940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N8Z00_RS03945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N8Z00_RS03950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N8Z00_RS03955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N8Z00_RS03960	COG0255	Belongs to the universal ribosomal protein uL29 family
N8Z00_RS03965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N8Z00_RS04010	COG2207	Transcriptional regulator
N8Z00_RS04030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N8Z00_RS04035	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N8Z00_RS04040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N8Z00_RS04045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N8Z00_RS04050	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N8Z00_RS04055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N8Z00_RS04060	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N8Z00_RS04065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N8Z00_RS04070	COG1841	ribosomal large subunit assembly
N8Z00_RS04075	COG0200	Binds to the 23S rRNA
N8Z00_RS04080	COG0201	protein transport
N8Z00_RS04085	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N8Z00_RS04090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N8Z00_RS04095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N8Z00_RS04100	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N8Z00_RS04105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N8Z00_RS04110	COG0202	RNA polymerase activity
N8Z00_RS04115	COG0203	ribosomal protein L17
N8Z00_RS04125	COG1324	tolerance protein
N8Z00_RS04130	COG4232	protein-disulfide reductase activity
N8Z00_RS04145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N8Z00_RS04155	COG1333	cytochrome c biogenesis protein
N8Z00_RS04160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N8Z00_RS04280	COG0019	diaminopimelate decarboxylase activity
N8Z00_RS04285	COG1965	Belongs to the frataxin family
N8Z00_RS04305	COG0747	negative chemotaxis
N8Z00_RS04310	COG0601	transmembrane transport
N8Z00_RS04315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS04330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N8Z00_RS04335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N8Z00_RS04340	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N8Z00_RS04355	COG2814	Major facilitator Superfamily
N8Z00_RS04365	COG0583	DNA-binding transcription factor activity
N8Z00_RS04370	COG4948	Mandelate Racemase Muconate Lactonizing
N8Z00_RS04375	COG4774	siderophore transport
N8Z00_RS04380	COG2207	Transcriptional regulator
N8Z00_RS04420	COG2186	Transcriptional regulator
N8Z00_RS04445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8Z00_RS04450	COG1956	GAF domain-containing protein
N8Z00_RS04455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8Z00_RS04470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N8Z00_RS04500	COG3568	Endonuclease Exonuclease Phosphatase
N8Z00_RS04505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N8Z00_RS04515	COG2814	Major facilitator Superfamily
N8Z00_RS04520	COG0756	dUTP diphosphatase activity
N8Z00_RS04530	COG1086	Polysaccharide biosynthesis protein
N8Z00_RS04535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N8Z00_RS04550	COG0367	asparagine synthase
N8Z00_RS04560	COG0673	inositol 2-dehydrogenase activity
N8Z00_RS04585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N8Z00_RS04620	COG0859	PFAM glycosyl transferase family 9
N8Z00_RS04635	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
N8Z00_RS04645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N8Z00_RS04670	COG1686	Belongs to the peptidase S11 family
N8Z00_RS04680	COG2921	Belongs to the UPF0250 family
N8Z00_RS04685	COG0321	lipoyl(octanoyl) transferase activity
N8Z00_RS04695	COG1609	Transcriptional regulator
N8Z00_RS04700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N8Z00_RS04715	COG1091	dTDP-4-dehydrorhamnose reductase activity
N8Z00_RS04735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N8Z00_RS04750	COG0523	cobalamin synthesis protein
N8Z00_RS04755	COG0735	belongs to the Fur family
N8Z00_RS04780	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
N8Z00_RS04785	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N8Z00_RS04795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N8Z00_RS04800	COG1560	Kdo2-lipid A biosynthetic process
N8Z00_RS04810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N8Z00_RS04815	COG0154	amidase activity
N8Z00_RS04825	COG1079	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS04845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N8Z00_RS04860	COG0583	DNA-binding transcription factor activity
N8Z00_RS04865	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS04870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N8Z00_RS04875	COG0066	3-isopropylmalate dehydratase activity
N8Z00_RS04880	COG0596	Alpha beta hydrolase
N8Z00_RS04890	COG0438	transferase activity, transferring glycosyl groups
N8Z00_RS04895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N8Z00_RS04900	COG1950	PFAM Membrane protein of
N8Z00_RS04905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N8Z00_RS04920	COG1305	Transglutaminase-like
N8Z00_RS04930	COG2308	Evidence 4 Homologs of previously reported genes of
N8Z00_RS04955	COG0513	Belongs to the DEAD box helicase family
N8Z00_RS04960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N8Z00_RS05000	COG0640	Transcriptional regulator
N8Z00_RS05055	COG1846	Transcriptional regulator
N8Z00_RS05060	COG1764	response to oxidative stress
N8Z00_RS05070	COG0583	DNA-binding transcription factor activity
N8Z00_RS05080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N8Z00_RS05085	COG0708	Exodeoxyribonuclease III
N8Z00_RS05090	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N8Z00_RS05100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N8Z00_RS05105	COG0154	amidase activity
N8Z00_RS05110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N8Z00_RS05115	COG1077	Cell shape determining protein MreB Mrl
N8Z00_RS05120	COG1792	Involved in formation and maintenance of cell shape
N8Z00_RS05130	COG0768	penicillin binding
N8Z00_RS05135	COG0772	Belongs to the SEDS family
N8Z00_RS05140	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N8Z00_RS05145	COG0471	metal ion transport
N8Z00_RS05150	COG1309	transcriptional regulator
N8Z00_RS05160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N8Z00_RS05165	COG1464	Belongs to the NlpA lipoprotein family
N8Z00_RS05170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N8Z00_RS05175	COG2823	Periplasmic or secreted lipoprotein
N8Z00_RS05180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N8Z00_RS05185	COG0792	nuclease activity
N8Z00_RS05195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N8Z00_RS05205	COG1660	Displays ATPase and GTPase activities
N8Z00_RS05220	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
N8Z00_RS05230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N8Z00_RS05235	COG1137	ATPase activity
N8Z00_RS05250	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N8Z00_RS05260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N8Z00_RS05270	COG1271	oxidase subunit
N8Z00_RS05275	COG1294	oxidase, subunit
N8Z00_RS05285	COG4988	ABC transporter
N8Z00_RS05290	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N8Z00_RS05310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N8Z00_RS05315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N8Z00_RS05320	COG1238	metal cluster binding
N8Z00_RS05330	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS05335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N8Z00_RS05340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8Z00_RS05345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS05360	COG0758	DNA mediated transformation
N8Z00_RS05365	COG0242	peptide deformylase activity
N8Z00_RS05370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N8Z00_RS05385	COG0546	phosphoglycolate phosphatase activity
N8Z00_RS05405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N8Z00_RS05415	COG3210	domain, Protein
N8Z00_RS05415	COG3210	domain, Protein
N8Z00_RS05465	COG1280	lysine exporter protein (LysE YggA)
N8Z00_RS05470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N8Z00_RS05470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N8Z00_RS05480	COG5000	phosphorelay sensor kinase activity
N8Z00_RS05485	COG2204	response regulator
N8Z00_RS05490	COG0569	domain protein
N8Z00_RS05495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N8Z00_RS05500	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N8Z00_RS05515	COG3220	belongs to the UPF0276 family
N8Z00_RS05530	COG1595	DNA-templated transcription, initiation
N8Z00_RS05535	COG2226	methyltransferase
N8Z00_RS05540	COG1040	competence protein
N8Z00_RS05545	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N8Z00_RS05550	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS05555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N8Z00_RS05560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N8Z00_RS05565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N8Z00_RS05570	COG1054	Belongs to the UPF0176 family
N8Z00_RS05575	COG0588	phosphoglycerate mutase activity
N8Z00_RS05580	COG4942	peptidase
N8Z00_RS05585	COG0793	Belongs to the peptidase S41A family
N8Z00_RS05600	COG2186	Transcriptional regulator
N8Z00_RS05615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N8Z00_RS05630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N8Z00_RS05635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N8Z00_RS05640	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N8Z00_RS05645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N8Z00_RS05650	COG1414	Transcriptional regulator
N8Z00_RS05660	COG0142	geranyltranstransferase activity
N8Z00_RS05670	COG0583	DNA-binding transcription factor activity
N8Z00_RS05715	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS05810	COG0659	secondary active sulfate transmembrane transporter activity
N8Z00_RS05820	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
N8Z00_RS05840	COG1024	Enoyl-CoA hydratase
N8Z00_RS05850	COG1309	transcriptional regulator
N8Z00_RS05860	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS05870	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS05875	COG0183	Belongs to the thiolase family
N8Z00_RS05925	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N8Z00_RS05960	COG1073	alpha beta
N8Z00_RS05960	COG2226	methyltransferase
N8Z00_RS05990	COG0683	leucine binding
N8Z00_RS05995	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8Z00_RS06000	COG2084	Dehydrogenase
N8Z00_RS06015	COG2814	Major facilitator Superfamily
N8Z00_RS06020	COG0235	Class ii aldolase
N8Z00_RS06025	COG2271	Major facilitator Superfamily
N8Z00_RS06030	COG3622	Belongs to the hyi family
N8Z00_RS06035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8Z00_RS06040	COG2084	Dehydrogenase
N8Z00_RS06045	COG3395	kinase activity
N8Z00_RS06055	COG2186	Transcriptional regulator
N8Z00_RS06075	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N8Z00_RS06080	COG3842	ATPase activity
N8Z00_RS06090	COG0402	S-adenosylhomocysteine deaminase activity
N8Z00_RS06115	COG3077	Addiction module antitoxin, RelB DinJ family
N8Z00_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS06130	COG0022	dehydrogenase e1 component
N8Z00_RS06145	COG0508	dehydrogenase complex catalyzes the overall conversion of
N8Z00_RS06155	COG0583	DNA-binding transcription factor activity
N8Z00_RS06190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS06195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N8Z00_RS06200	COG3622	Belongs to the hyi family
N8Z00_RS06210	COG5006	permease, DMT superfamily
N8Z00_RS06215	COG1522	sequence-specific DNA binding
N8Z00_RS06220	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N8Z00_RS06220	COG3264	Mechanosensitive ion channel
N8Z00_RS06225	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS06235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8Z00_RS06240	COG1116	anion transmembrane transporter activity
N8Z00_RS06275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N8Z00_RS06280	COG2890	protein-(glutamine-N5) methyltransferase activity
N8Z00_RS06285	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N8Z00_RS06295	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS06305	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS06330	COG0583	DNA-binding transcription factor activity
N8Z00_RS06345	COG0625	glutathione transferase activity
N8Z00_RS06350	COG0288	reversible hydration of carbon dioxide
N8Z00_RS06370	COG0596	Alpha beta hydrolase
N8Z00_RS06380	COG4829	muconolactone delta-isomerase
N8Z00_RS06385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N8Z00_RS06395	COG1414	Transcriptional regulator
N8Z00_RS06400	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS06405	COG2031	fatty acid transporter
N8Z00_RS06410	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS06415	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N8Z00_RS06420	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N8Z00_RS06440	COG0129	dihydroxy-acid dehydratase activity
N8Z00_RS06445	COG0583	DNA-binding transcription factor activity
N8Z00_RS06450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N8Z00_RS06455	COG0508	dehydrogenase complex catalyzes the overall conversion of
N8Z00_RS06465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
N8Z00_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS06475	COG0410	ABC transporter
N8Z00_RS06505	COG2186	Transcriptional regulator
N8Z00_RS06515	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
N8Z00_RS06530	COG2177	Part of the ABC transporter FtsEX involved in
N8Z00_RS06535	COG2884	Cell division ATP-binding protein ftsE
N8Z00_RS06540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS06545	COG4597	amino acid ABC transporter
N8Z00_RS06550	COG0765	amino acid transport
N8Z00_RS06555	COG1126	abc transporter atp-binding protein
N8Z00_RS06560	COG3657	addiction module killer protein
N8Z00_RS06565	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N8Z00_RS06580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8Z00_RS06585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N8Z00_RS06595	COG1605	Chorismate mutase
N8Z00_RS06595	COG0077	Prephenate dehydratase
N8Z00_RS06600	COG0625	glutathione transferase activity
N8Z00_RS06640	COG0583	DNA-binding transcription factor activity
N8Z00_RS06645	COG0628	permease
N8Z00_RS06660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8Z00_RS06665	COG1176	ABC-type spermidine putrescine transport system, permease component I
N8Z00_RS06680	COG0277	FAD linked oxidase domain protein
N8Z00_RS06690	COG0477	Major facilitator Superfamily
N8Z00_RS06705	COG1695	Transcriptional regulator
N8Z00_RS06715	COG0583	DNA-binding transcription factor activity
N8Z00_RS06765	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS06775	COG3246	L-lysine catabolic process to acetate
N8Z00_RS06780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N8Z00_RS06785	COG1172	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS06800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N8Z00_RS06805	COG0210	DNA helicase
N8Z00_RS06810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS06820	COG0583	DNA-binding transcription factor activity
N8Z00_RS06825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N8Z00_RS06830	COG0477	Major facilitator Superfamily
N8Z00_RS06840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
N8Z00_RS06845	COG2010	Cytochrome c
N8Z00_RS06845	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N8Z00_RS06850	COG1335	isochorismatase
N8Z00_RS06855	COG2309	aminopeptidase activity
N8Z00_RS06860	COG0596	Alpha beta hydrolase
N8Z00_RS06865	COG3473	Maleate cis-trans isomerase
N8Z00_RS06875	COG2080	2 iron, 2 sulfur cluster binding
N8Z00_RS06880	COG2010	Cytochrome c
N8Z00_RS06880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N8Z00_RS06885	COG0477	Major facilitator Superfamily
N8Z00_RS06890	COG1846	Transcriptional regulator
N8Z00_RS06905	COG4977	sequence-specific DNA binding
N8Z00_RS06905	COG1917	Cupin 2, conserved barrel domain protein
N8Z00_RS06985	COG2233	PERMEase
N8Z00_RS06990	COG0326	Molecular chaperone. Has ATPase activity
N8Z00_RS06995	COG1396	sequence-specific DNA binding
N8Z00_RS07010	COG0604	alcohol dehydrogenase
N8Z00_RS07040	COG2814	Major facilitator Superfamily
N8Z00_RS07045	COG2271	Major facilitator Superfamily
N8Z00_RS07050	COG4948	Mandelate Racemase Muconate Lactonizing
N8Z00_RS07055	COG0800	Aldolase
N8Z00_RS07060	COG3734	2-keto-3-deoxy-galactonokinase
N8Z00_RS07065	COG1414	Transcriptional regulator
N8Z00_RS07070	COG0625	glutathione transferase activity
N8Z00_RS07085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N8Z00_RS07090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N8Z00_RS07095	COG1652	LysM domain
N8Z00_RS07115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N8Z00_RS07140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N8Z00_RS07170	COG3246	L-lysine catabolic process to acetate
N8Z00_RS07180	COG2072	flavoprotein involved in K transport
N8Z00_RS07185	COG3842	ATPase activity
N8Z00_RS07205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N8Z00_RS07210	COG1177	transmembrane transport
N8Z00_RS07215	COG1176	ABC-type spermidine putrescine transport system, permease component I
N8Z00_RS07235	COG0583	DNA-binding transcription factor activity
N8Z00_RS07245	COG0165	Argininosuccinate lyase
N8Z00_RS07255	COG2814	Major facilitator Superfamily
N8Z00_RS07260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8Z00_RS07265	COG3152	Membrane
N8Z00_RS07295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS07305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N8Z00_RS07335	COG2828	Protein conserved in bacteria
N8Z00_RS07355	COG3284	Transcriptional regulator
N8Z00_RS07375	COG0583	DNA-binding transcription factor activity
N8Z00_RS07385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N8Z00_RS07390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8Z00_RS07395	COG1131	(ABC) transporter
N8Z00_RS07515	COG1280	lysine exporter protein (LysE YggA)
N8Z00_RS07520	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
N8Z00_RS07530	COG1605	Chorismate mutase
N8Z00_RS07530	COG0077	Prephenate dehydratase
N8Z00_RS07540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N8Z00_RS07550	COG0512	Glutamine amidotransferase of anthranilate synthase
N8Z00_RS07560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8Z00_RS07600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N8Z00_RS07615	COG3618	amidohydrolase
N8Z00_RS07620	COG0583	DNA-binding transcription factor activity
N8Z00_RS07625	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS07630	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS07640	COG1024	Enoyl-CoA hydratase
N8Z00_RS07675	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS07710	COG0625	glutathione transferase activity
N8Z00_RS07720	COG0431	NADPH-dependent FMN reductase
N8Z00_RS07720	COG1053	succinate dehydrogenase
N8Z00_RS07720	COG3976	FMN-binding domain protein
N8Z00_RS07740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8Z00_RS07750	COG1294	oxidase, subunit
N8Z00_RS07755	COG1271	oxidase subunit
N8Z00_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS07775	COG2200	EAL domain
N8Z00_RS07780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N8Z00_RS07785	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS07810	COG1054	Belongs to the UPF0176 family
N8Z00_RS07815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N8Z00_RS07815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N8Z00_RS07825	COG0489	protein tyrosine kinase activity
N8Z00_RS07840	COG0717	Belongs to the dCTP deaminase family
N8Z00_RS07850	COG2203	Gaf domain
N8Z00_RS07850	COG3706	GGDEF domain
N8Z00_RS07850	COG4251	negative regulation of phosphorylation
N8Z00_RS07850	COG5001	Diguanylate cyclase
N8Z00_RS07870	COG2081	HI0933 family
N8Z00_RS07885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N8Z00_RS07890	COG0509	glycine decarboxylation via glycine cleavage system
N8Z00_RS07895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N8Z00_RS07895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N8Z00_RS07910	COG0154	amidase activity
N8Z00_RS07920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS07925	COG0601	transmembrane transport
N8Z00_RS07945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N8Z00_RS07950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8Z00_RS07970	COG1765	OsmC-like protein
N8Z00_RS07975	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
N8Z00_RS07980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N8Z00_RS07985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N8Z00_RS08010	COG0438	transferase activity, transferring glycosyl groups
N8Z00_RS08015	COG0438	transferase activity, transferring glycosyl groups
N8Z00_RS08020	COG0438	transferase activity, transferring glycosyl groups
N8Z00_RS08025	COG0166	Belongs to the GPI family
N8Z00_RS08040	COG0277	FAD linked oxidase domain protein
N8Z00_RS08045	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS08050	COG2205	protein histidine kinase activity
N8Z00_RS08060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8Z00_RS08060	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N8Z00_RS08070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N8Z00_RS08080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8Z00_RS08085	COG2186	Transcriptional regulator
N8Z00_RS08090	COG1368	sulfuric ester hydrolase activity
N8Z00_RS08100	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
N8Z00_RS08115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8Z00_RS08125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N8Z00_RS08135	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N8Z00_RS08140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N8Z00_RS08145	COG1309	transcriptional regulator
N8Z00_RS08150	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS08155	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
N8Z00_RS08160	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N8Z00_RS08180	COG0193	aminoacyl-tRNA hydrolase activity
N8Z00_RS08190	COG0012	GTP binding
N8Z00_RS08205	COG2814	Major facilitator Superfamily
N8Z00_RS08220	COG3135	benzoate transporter
N8Z00_RS08225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N8Z00_RS08230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N8Z00_RS08235	COG0742	ribosomal rna small subunit methyltransferase
N8Z00_RS08270	COG3639	organic phosphonate transmembrane transporter activity
N8Z00_RS08275	COG3639	organic phosphonate transmembrane transporter activity
N8Z00_RS08280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
N8Z00_RS08305	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N8Z00_RS08310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N8Z00_RS08325	COG1546	Belongs to the CinA family
N8Z00_RS08330	COG0284	orotidine-5'-phosphate decarboxylase activity
N8Z00_RS08335	COG1252	NADH dehydrogenase
N8Z00_RS08340	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N8Z00_RS08350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N8Z00_RS08360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8Z00_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS08375	COG2721	sulfolactate sulfo-lyase activity
N8Z00_RS08380	COG0246	Mannitol dehydrogenase
N8Z00_RS08390	COG0410	ABC transporter
N8Z00_RS08395	COG1137	ATPase activity
N8Z00_RS08405	COG0559	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS08420	COG1917	Cupin 2, conserved barrel domain protein
N8Z00_RS08435	COG0459	protein refolding
N8Z00_RS08440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N8Z00_RS08445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS08450	COG1024	Enoyl-CoA hydratase
N8Z00_RS08455	COG3842	ATPase activity
N8Z00_RS08460	COG1177	transmembrane transport
N8Z00_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS08490	COG0583	DNA-binding transcription factor activity
N8Z00_RS08515	COG2130	NADP-dependent
N8Z00_RS08545	COG2301	Belongs to the HpcH HpaI aldolase family
N8Z00_RS08550	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS08590	COG2203	Gaf domain
N8Z00_RS08590	COG3706	GGDEF domain
N8Z00_RS08590	COG4251	negative regulation of phosphorylation
N8Z00_RS08590	COG5001	Diguanylate cyclase
N8Z00_RS08620	COG3321	synthase
N8Z00_RS08620	COG0604	alcohol dehydrogenase
N8Z00_RS08670	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS08675	COG2205	protein histidine kinase activity
N8Z00_RS08685	COG0438	transferase activity, transferring glycosyl groups
N8Z00_RS08710	COG4753	response regulator
N8Z00_RS08710	COG2207	Transcriptional regulator
N8Z00_RS08715	COG0596	Alpha beta hydrolase
N8Z00_RS08730	COG0477	Major facilitator Superfamily
N8Z00_RS08760	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS08765	COG2205	protein histidine kinase activity
N8Z00_RS08765	COG2198	Histidine kinase
N8Z00_RS08765	COG0784	Response regulator, receiver
N8Z00_RS08765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS08785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N8Z00_RS08825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N8Z00_RS08830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N8Z00_RS08835	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS08875	COG0277	FAD linked oxidase domain protein
N8Z00_RS08880	COG1414	Transcriptional regulator
N8Z00_RS08890	COG0583	DNA-binding transcription factor activity
N8Z00_RS08940	COG1595	DNA-templated transcription, initiation
N8Z00_RS08945	COG3712	iron ion homeostasis
N8Z00_RS09010	COG1764	response to oxidative stress
N8Z00_RS09015	COG0583	DNA-binding transcription factor activity
N8Z00_RS09025	COG1595	DNA-templated transcription, initiation
N8Z00_RS09040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8Z00_RS09045	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS09055	COG0387	Pfam Sodium calcium exchanger
N8Z00_RS09070	COG3135	benzoate transporter
N8Z00_RS09080	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
N8Z00_RS09080	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
N8Z00_RS09095	COG2188	Transcriptional regulator
N8Z00_RS09100	COG1280	lysine exporter protein (LysE YggA)
N8Z00_RS09110	COG3387	PFAM Glycoside hydrolase 15-related
N8Z00_RS09120	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS09125	COG3119	arylsulfatase activity
N8Z00_RS09150	COG2353	YceI-like domain
N8Z00_RS09170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8Z00_RS09190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N8Z00_RS09205	COG0642	Histidine kinase
N8Z00_RS09220	COG2837	iron assimilation
N8Z00_RS09225	COG0840	transmembrane signaling receptor activity
N8Z00_RS09250	COG0667	Aldo Keto reductase
N8Z00_RS09270	COG0519	Catalyzes the synthesis of GMP from XMP
N8Z00_RS09295	COG2197	response regulator
N8Z00_RS09300	COG2205	protein histidine kinase activity
N8Z00_RS09300	COG0784	Response regulator, receiver
N8Z00_RS09305	COG4943	cyclic-guanylate-specific phosphodiesterase activity
N8Z00_RS09335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N8Z00_RS09345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N8Z00_RS09360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N8Z00_RS09365	COG1845	cytochrome c oxidase, subunit III
N8Z00_RS09370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N8Z00_RS09375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N8Z00_RS09380	COG0477	Major facilitator Superfamily
N8Z00_RS09410	COG0583	DNA-binding transcription factor activity
N8Z00_RS09415	COG0861	Integral membrane protein TerC family
N8Z00_RS09420	COG4106	trans-aconitate 2-methyltransferase activity
N8Z00_RS09425	COG2207	Transcriptional regulator
N8Z00_RS09430	COG2807	transmembrane transport
N8Z00_RS09445	COG0330	HflC and HflK could
N8Z00_RS09455	COG1595	DNA-templated transcription, initiation
N8Z00_RS09460	COG3712	iron ion homeostasis
N8Z00_RS09475	COG1595	DNA-templated transcription, initiation
N8Z00_RS09480	COG3712	iron ion homeostasis
N8Z00_RS09490	COG2706	6-phosphogluconolactonase activity
N8Z00_RS09500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N8Z00_RS09515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N8Z00_RS09520	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS09525	COG1285	pathogenesis
N8Z00_RS09530	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS09535	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
N8Z00_RS09560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N8Z00_RS09565	COG1396	sequence-specific DNA binding
N8Z00_RS09585	COG0583	DNA-binding transcription factor activity
N8Z00_RS09590	COG0300	oxidoreductase activity
N8Z00_RS09600	COG0583	DNA-binding transcription factor activity
N8Z00_RS09615	COG0697	spore germination
N8Z00_RS09630	COG0281	malic enzyme
N8Z00_RS09630	COG0280	phosphate acetyltransferase
N8Z00_RS09635	COG0583	DNA-binding transcription factor activity
N8Z00_RS09640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N8Z00_RS09655	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
N8Z00_RS09660	COG2900	Belongs to the SlyX family
N8Z00_RS09665	COG4772	TonB-dependent receptor
N8Z00_RS09680	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
N8Z00_RS09685	COG1845	cytochrome c oxidase, subunit III
N8Z00_RS09690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N8Z00_RS09700	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
N8Z00_RS09715	COG1999	signal sequence binding
N8Z00_RS09730	COG1126	abc transporter atp-binding protein
N8Z00_RS09735	COG0765	amino acid transport
N8Z00_RS09740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS09745	COG3191	aminopeptidase activity
N8Z00_RS09750	COG1272	protein, Hemolysin III
N8Z00_RS09755	COG1522	sequence-specific DNA binding
N8Z00_RS09790	COG1595	DNA-templated transcription, initiation
N8Z00_RS09795	COG3712	iron ion homeostasis
N8Z00_RS09805	COG3720	iron ion transport
N8Z00_RS09810	COG4558	Periplasmic binding protein
N8Z00_RS09815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N8Z00_RS09820	COG1120	ATPase activity
N8Z00_RS09825	COG1666	GTP binding
N8Z00_RS09855	COG0671	phosphoesterase, PA-phosphatase related
N8Z00_RS09935	COG0583	DNA-binding transcription factor activity
N8Z00_RS09940	COG2828	Protein conserved in bacteria
N8Z00_RS09950	COG1943	Transposase
N8Z00_RS09965	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS10010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N8Z00_RS10015	COG0583	DNA-binding transcription factor activity
N8Z00_RS10035	COG2223	nitrite transmembrane transporter activity
N8Z00_RS10045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N8Z00_RS10050	COG3383	formate dehydrogenase (NAD+) activity
N8Z00_RS10070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N8Z00_RS10080	COG0303	'Molybdopterin
N8Z00_RS10085	COG0521	Mo-molybdopterin cofactor biosynthetic process
N8Z00_RS10090	COG0314	molybdopterin synthase activity
N8Z00_RS10100	COG0315	cyclic pyranopterin monophosphate synthase activity
N8Z00_RS10110	COG0412	Dienelactone hydrolase
N8Z00_RS10120	COG0678	peroxiredoxin activity
N8Z00_RS10120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N8Z00_RS10130	COG0697	spore germination
N8Z00_RS10135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N8Z00_RS10175	COG0667	Aldo Keto reductase
N8Z00_RS10180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N8Z00_RS10185	COG4535	Mg2 and Co2 transporter CorC
N8Z00_RS10190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N8Z00_RS10195	COG1702	phosphate starvation-inducible protein PhoH
N8Z00_RS10200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N8Z00_RS10210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N8Z00_RS10225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N8Z00_RS10230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N8Z00_RS10235	COG1862	Preprotein translocase
N8Z00_RS10240	COG0343	queuine tRNA-ribosyltransferase activity
N8Z00_RS10245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N8Z00_RS10250	COG2027	D-alanyl-D-alanine carboxypeptidase
N8Z00_RS10255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N8Z00_RS10260	COG1648	precorrin-2 dehydrogenase activity
N8Z00_RS10260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N8Z00_RS10270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N8Z00_RS10275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8Z00_RS10280	COG1116	anion transmembrane transporter activity
N8Z00_RS10285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N8Z00_RS10290	COG0243	molybdopterin cofactor binding
N8Z00_RS10300	COG4575	ribosome binding
N8Z00_RS10315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N8Z00_RS10320	COG0741	lytic transglycosylase activity
N8Z00_RS10325	COG0436	Aminotransferase
N8Z00_RS10335	COG0280	phosphate acetyltransferase
N8Z00_RS10335	COG0281	malic enzyme
N8Z00_RS10345	COG2732	(Barnase) inhibitor
N8Z00_RS10350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N8Z00_RS10360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N8Z00_RS10365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N8Z00_RS10370	COG0126	phosphoglycerate kinase activity
N8Z00_RS10385	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N8Z00_RS10390	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N8Z00_RS10405	COG0625	glutathione transferase activity
N8Z00_RS10435	COG0306	phosphate transporter
N8Z00_RS10440	COG0521	Mo-molybdopterin cofactor biosynthetic process
N8Z00_RS10450	COG0739	heme binding
N8Z00_RS10460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N8Z00_RS10470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
N8Z00_RS10475	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
N8Z00_RS10480	COG3639	organic phosphonate transmembrane transporter activity
N8Z00_RS10500	COG0583	DNA-binding transcription factor activity
N8Z00_RS10505	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
N8Z00_RS10510	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
N8Z00_RS10515	COG3454	Phosphonate metabolism
N8Z00_RS10520	COG2188	Transcriptional regulator
N8Z00_RS10525	COG3624	Phosphonate C-P lyase system protein PhnG
N8Z00_RS10535	COG3626	phosphonate metabolism
N8Z00_RS10540	COG3627	carbon phosphorus lyase activity
N8Z00_RS10545	COG4107	phosphonate C-P lyase system protein PhnK
N8Z00_RS10550	COG4778	phosphonate C-P lyase system protein PhnL
N8Z00_RS10555	COG3454	Phosphonate metabolism
N8Z00_RS10585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N8Z00_RS10605	COG4172	Belongs to the ABC transporter superfamily
N8Z00_RS10625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N8Z00_RS10635	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N8Z00_RS10640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N8Z00_RS10645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N8Z00_RS10650	COG0009	L-threonylcarbamoyladenylate synthase
N8Z00_RS10655	COG1414	Transcriptional regulator
N8Z00_RS10660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N8Z00_RS10675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS10680	COG1414	Transcriptional regulator
N8Z00_RS10685	COG0010	Belongs to the arginase family
N8Z00_RS10690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS10695	COG0765	amino acid transport
N8Z00_RS10700	COG1126	abc transporter atp-binding protein
N8Z00_RS10705	COG0028	Belongs to the TPP enzyme family
N8Z00_RS10745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N8Z00_RS10770	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS10775	COG0028	Belongs to the TPP enzyme family
N8Z00_RS10780	COG0583	DNA-binding transcription factor activity
N8Z00_RS10785	COG4974	Belongs to the 'phage' integrase family
N8Z00_RS10810	COG0601	transmembrane transport
N8Z00_RS10815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS10825	COG4638	Rieske (2fe-2S)
N8Z00_RS10835	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
N8Z00_RS10850	COG1686	Belongs to the peptidase S11 family
N8Z00_RS10865	COG2205	protein histidine kinase activity
N8Z00_RS10880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N8Z00_RS10890	COG2271	Major facilitator Superfamily
N8Z00_RS10905	COG1074	ATP-dependent DNA helicase activity
N8Z00_RS10915	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N8Z00_RS10930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS10935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N8Z00_RS10945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8Z00_RS10960	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS10975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N8Z00_RS10980	COG0505	Belongs to the CarA family
N8Z00_RS10985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N8Z00_RS10995	COG0406	alpha-ribazole phosphatase activity
N8Z00_RS11005	COG3842	ATPase activity
N8Z00_RS11025	COG2233	PERMEase
N8Z00_RS11030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N8Z00_RS11035	COG1534	Rna-binding protein
N8Z00_RS11040	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N8Z00_RS11045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N8Z00_RS11055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N8Z00_RS11065	COG0248	Ppx GppA phosphatase
N8Z00_RS11090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N8Z00_RS11105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N8Z00_RS11110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS11120	COG4948	Mandelate Racemase Muconate Lactonizing
N8Z00_RS11125	COG0028	Belongs to the TPP enzyme family
N8Z00_RS11135	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS11145	COG2186	Transcriptional regulator
N8Z00_RS11160	COG0583	DNA-binding transcription factor activity
N8Z00_RS11170	COG0384	phenazine biosynthesis protein PhzF
N8Z00_RS11180	COG3971	2-oxopent-4-enoate hydratase activity
N8Z00_RS11200	COG0583	DNA-binding transcription factor activity
N8Z00_RS11205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N8Z00_RS11210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS11245	COG2207	Transcriptional regulator
N8Z00_RS11250	COG0667	Aldo Keto reductase
N8Z00_RS11275	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
N8Z00_RS11290	COG0500	methyltransferase
N8Z00_RS11295	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS11315	COG0559	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS11325	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS11330	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS11340	COG0371	Dehydrogenase
N8Z00_RS11345	COG1802	Transcriptional regulator
N8Z00_RS11350	COG3959	Transketolase, thiamine diphosphate binding domain
N8Z00_RS11355	COG3958	Transketolase
N8Z00_RS11360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N8Z00_RS11370	COG3938	Belongs to the proline racemase family
N8Z00_RS11375	COG1177	transmembrane transport
N8Z00_RS11380	COG1176	ABC-type spermidine putrescine transport system, permease component I
N8Z00_RS11385	COG3842	ATPase activity
N8Z00_RS11440	COG3264	Mechanosensitive ion channel
N8Z00_RS11440	COG1511	domain protein
N8Z00_RS11445	COG0583	DNA-binding transcription factor activity
N8Z00_RS11450	COG0427	acetyl-CoA hydrolase
N8Z00_RS11455	COG0583	DNA-binding transcription factor activity
N8Z00_RS11480	COG0235	Class ii aldolase
N8Z00_RS11490	COG0583	DNA-binding transcription factor activity
N8Z00_RS11505	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS11510	COG0477	Major facilitator Superfamily
N8Z00_RS11520	COG0154	amidase activity
N8Z00_RS11535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N8Z00_RS11550	COG0495	leucyl-tRNA aminoacylation
N8Z00_RS11555	COG2814	Major facilitator Superfamily
N8Z00_RS11560	COG1846	Transcriptional regulator
N8Z00_RS11570	COG1686	Belongs to the peptidase S11 family
N8Z00_RS11595	COG0683	leucine binding
N8Z00_RS11600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N8Z00_RS11605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N8Z00_RS11610	COG2814	Major facilitator Superfamily
N8Z00_RS11615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N8Z00_RS11625	COG4176	ABC-type proline glycine betaine transport system permease component
N8Z00_RS11645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS11655	COG0183	Belongs to the thiolase family
N8Z00_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS11665	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS11670	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS11685	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS11695	COG2271	Major facilitator Superfamily
N8Z00_RS11705	COG3485	protocatechuate 3,4-dioxygenase
N8Z00_RS11710	COG3485	protocatechuate 3,4-dioxygenase
N8Z00_RS11715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N8Z00_RS11755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N8Z00_RS11760	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N8Z00_RS11780	COG4585	Histidine kinase
N8Z00_RS11835	COG1063	alcohol dehydrogenase
N8Z00_RS11845	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
N8Z00_RS11850	COG1228	amidohydrolase
N8Z00_RS11855	COG1024	Enoyl-CoA hydratase
N8Z00_RS11885	COG0673	inositol 2-dehydrogenase activity
N8Z00_RS11890	COG1609	Transcriptional regulator
N8Z00_RS11895	COG1024	Enoyl-CoA hydratase
N8Z00_RS11895	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS11915	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
N8Z00_RS11920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS11925	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS11935	COG2015	COG2015, Alkyl sulfatase and related hydrolases
N8Z00_RS11940	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS11950	COG1396	sequence-specific DNA binding
N8Z00_RS11965	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
N8Z00_RS11970	COG1116	anion transmembrane transporter activity
N8Z00_RS11975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8Z00_RS11980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N8Z00_RS11985	COG2197	response regulator
N8Z00_RS12005	COG0583	DNA-binding transcription factor activity
N8Z00_RS12015	COG4172	Belongs to the ABC transporter superfamily
N8Z00_RS12020	COG0402	S-adenosylhomocysteine deaminase activity
N8Z00_RS12025	COG0747	negative chemotaxis
N8Z00_RS12030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS12035	COG0601	transmembrane transport
N8Z00_RS12040	COG2423	ornithine cyclodeaminase activity
N8Z00_RS12050	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS12070	COG0765	amino acid transport
N8Z00_RS12075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8Z00_RS12140	COG1024	Enoyl-CoA hydratase
N8Z00_RS12145	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS12150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N8Z00_RS12165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS12175	COG2070	2-Nitropropane dioxygenase
N8Z00_RS12190	COG1278	Cold shock
N8Z00_RS12215	COG3485	protocatechuate 3,4-dioxygenase
N8Z00_RS12220	COG3485	protocatechuate 3,4-dioxygenase
N8Z00_RS12225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8Z00_RS12230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N8Z00_RS12235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N8Z00_RS12240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N8Z00_RS12245	COG1414	Transcriptional regulator
N8Z00_RS12255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N8Z00_RS12270	COG1228	amidohydrolase
N8Z00_RS12280	COG1024	Enoyl-CoA hydratase
N8Z00_RS12305	COG2080	2 iron, 2 sulfur cluster binding
N8Z00_RS12310	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
N8Z00_RS12315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N8Z00_RS12330	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS12340	COG0583	DNA-binding transcription factor activity
N8Z00_RS12355	COG3188	usher protein
N8Z00_RS12360	COG3121	Chaperone
N8Z00_RS12385	COG2197	response regulator
N8Z00_RS12400	COG1802	Transcriptional regulator
N8Z00_RS12430	COG1024	Enoyl-CoA hydratase
N8Z00_RS12440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N8Z00_RS12455	COG0625	glutathione transferase activity
N8Z00_RS12480	COG3756	Protein conserved in bacteria
N8Z00_RS12590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8Z00_RS12645	COG2321	neutral zinc metallopeptidase
N8Z00_RS12650	COG0009	L-threonylcarbamoyladenylate synthase
N8Z00_RS12655	COG1994	Peptidase M50
N8Z00_RS12660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8Z00_RS12665	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
N8Z00_RS12675	COG2850	peptidyl-arginine hydroxylation
N8Z00_RS12700	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS12715	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS12725	COG1024	Enoyl-CoA hydratase
N8Z00_RS12735	COG0583	DNA-binding transcription factor activity
N8Z00_RS12740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8Z00_RS12745	COG0426	domain, Protein
N8Z00_RS12745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N8Z00_RS12760	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS12765	COG0583	DNA-binding transcription factor activity
N8Z00_RS12775	COG3360	Dodecin
N8Z00_RS12795	COG1802	Transcriptional regulator
N8Z00_RS12815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8Z00_RS12820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N8Z00_RS12830	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS12835	COG0235	Class ii aldolase
N8Z00_RS12865	COG0668	transmembrane transport
N8Z00_RS12885	COG0483	inositol monophosphate 1-phosphatase activity
N8Z00_RS12890	COG1253	flavin adenine dinucleotide binding
N8Z00_RS12895	COG1968	undecaprenyl-diphosphatase activity
N8Z00_RS12900	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N8Z00_RS12915	COG0215	cysteine-tRNA ligase activity
N8Z00_RS12925	COG0825	malonyl-CoA metabolic process
N8Z00_RS12945	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
N8Z00_RS12975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N8Z00_RS12985	COG1414	Transcriptional regulator
N8Z00_RS12995	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS13010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N8Z00_RS13015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N8Z00_RS13020	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS13030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N8Z00_RS13035	COG3395	kinase activity
N8Z00_RS13045	COG4774	siderophore transport
N8Z00_RS13055	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS13065	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS13080	COG0183	Belongs to the thiolase family
N8Z00_RS13085	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS13085	COG1024	Enoyl-CoA hydratase
N8Z00_RS13095	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS13095	COG1024	Enoyl-CoA hydratase
N8Z00_RS13100	COG0183	Belongs to the thiolase family
N8Z00_RS13120	COG2197	response regulator
N8Z00_RS13125	COG2197	response regulator
N8Z00_RS13130	COG0297	glycogen (starch) synthase activity
N8Z00_RS13135	COG0110	maltose O-acetyltransferase activity
N8Z00_RS13165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8Z00_RS13185	COG1051	belongs to the nudix hydrolase family
N8Z00_RS13210	COG0166	Belongs to the GPI family
N8Z00_RS13215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N8Z00_RS13220	COG1045	serine acetyltransferase
N8Z00_RS13225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N8Z00_RS13230	COG0483	inositol monophosphate 1-phosphatase activity
N8Z00_RS13240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N8Z00_RS13260	COG0598	Magnesium transport protein CorA
N8Z00_RS13275	COG0601	transmembrane transport
N8Z00_RS13280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS13285	COG4172	Belongs to the ABC transporter superfamily
N8Z00_RS13290	COG1846	Transcriptional regulator
N8Z00_RS13335	COG4964	Belongs to the GSP D family
N8Z00_RS13390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N8Z00_RS13405	COG3384	dioxygenase
N8Z00_RS13410	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N8Z00_RS13420	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS13475	COG0517	IMP dehydrogenase activity
N8Z00_RS13480	COG0583	DNA-binding transcription factor activity
N8Z00_RS13490	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS13495	COG1024	Enoyl-CoA hydratase
N8Z00_RS13500	COG0183	Belongs to the thiolase family
N8Z00_RS13510	COG1024	Enoyl-CoA hydratase
N8Z00_RS13515	COG0045	succinate-CoA ligase (ADP-forming) activity
N8Z00_RS13515	COG1042	CoA-binding domain protein
N8Z00_RS13515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N8Z00_RS13525	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS13540	COG1802	Transcriptional regulator
N8Z00_RS13550	COG1024	Enoyl-CoA hydratase
N8Z00_RS13555	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS13565	COG0667	Aldo Keto reductase
N8Z00_RS13575	COG4120	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS13585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8Z00_RS13595	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N8Z00_RS13620	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
N8Z00_RS13625	COG0725	ABC transporter, periplasmic molybdate-binding protein
N8Z00_RS13630	COG4149	molybdate abc transporter
N8Z00_RS13635	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N8Z00_RS13660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N8Z00_RS13665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N8Z00_RS13675	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N8Z00_RS13680	COG0736	holo-[acyl-carrier-protein] synthase activity
N8Z00_RS13695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N8Z00_RS13710	COG1473	amidohydrolase
N8Z00_RS13715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N8Z00_RS13715	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N8Z00_RS13720	COG2224	Isocitrate lyase
N8Z00_RS13725	COG1064	alcohol dehydrogenase
N8Z00_RS13730	COG0583	DNA-binding transcription factor activity
N8Z00_RS13740	COG3609	addiction module antidote protein, CC2985 family
N8Z00_RS13745	COG4106	trans-aconitate 2-methyltransferase activity
N8Z00_RS13745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N8Z00_RS13755	COG0156	8-amino-7-oxononanoate synthase activity
N8Z00_RS13775	COG3278	Belongs to the heme-copper respiratory oxidase family
N8Z00_RS13795	COG0348	domain, Protein
N8Z00_RS13810	COG2824	Alkylphosphonate utilization operon protein PhnA
N8Z00_RS13820	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS13840	COG1131	(ABC) transporter
N8Z00_RS13845	COG0842	Transport permease protein
N8Z00_RS13870	COG1272	protein, Hemolysin III
N8Z00_RS13895	COG2169	Transcriptional regulator
N8Z00_RS13910	COG4942	peptidase
N8Z00_RS13925	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS13935	COG3708	Transcriptional regulator
N8Z00_RS13935	COG2207	Transcriptional regulator
N8Z00_RS13940	COG2814	Major facilitator Superfamily
N8Z00_RS13950	COG0747	negative chemotaxis
N8Z00_RS13955	COG0601	transmembrane transport
N8Z00_RS13960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS13965	COG4608	Belongs to the ABC transporter superfamily
N8Z00_RS13970	COG0444	Belongs to the ABC transporter superfamily
N8Z00_RS14020	COG3618	amidohydrolase
N8Z00_RS14040	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
N8Z00_RS14045	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS14060	COG0583	DNA-binding transcription factor activity
N8Z00_RS14075	COG2951	lytic endotransglycosylase activity
N8Z00_RS14110	COG0601	transmembrane transport
N8Z00_RS14115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS14125	COG0456	acetyltransferase
N8Z00_RS14130	COG0488	(ABC) transporter
N8Z00_RS14135	COG1522	sequence-specific DNA binding
N8Z00_RS14170	COG3530	Putative quorum-sensing-regulated virulence factor
N8Z00_RS14190	COG0443	Heat shock 70 kDa protein
N8Z00_RS14195	COG0494	nUDIX hydrolase
N8Z00_RS14230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N8Z00_RS14240	COG0542	response to heat
N8Z00_RS14255	COG5441	Belongs to the UPF0261 family
N8Z00_RS14260	COG5564	TIM-barrel signal transduction protein
N8Z00_RS14270	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
N8Z00_RS14285	COG1477	protein flavinylation
N8Z00_RS14305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N8Z00_RS14315	COG1562	ergosterol biosynthetic process
N8Z00_RS14320	COG1562	ergosterol biosynthetic process
N8Z00_RS14325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N8Z00_RS14330	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS14340	COG3971	2-oxopent-4-enoate hydratase activity
N8Z00_RS14350	COG0179	Fumarylacetoacetate (FAA) hydrolase
N8Z00_RS14355	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS14360	COG3384	dioxygenase
N8Z00_RS14390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N8Z00_RS14400	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS14410	COG2186	Transcriptional regulator
N8Z00_RS14415	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N8Z00_RS14420	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS14435	COG0583	DNA-binding transcription factor activity
N8Z00_RS14440	COG0268	Binds directly to 16S ribosomal RNA
N8Z00_RS14450	COG0728	peptidoglycan biosynthetic process
N8Z00_RS14460	COG0563	adenylate kinase activity
N8Z00_RS14465	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N8Z00_RS14470	COG2835	tetraacyldisaccharide 4'-kinase activity
N8Z00_RS14480	COG1663	tetraacyldisaccharide 4'-kinase activity
N8Z00_RS14490	COG0811	peptide transport
N8Z00_RS14495	COG1570	exodeoxyribonuclease VII activity
N8Z00_RS14500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N8Z00_RS14510	COG0038	chloride channel
N8Z00_RS14515	COG0183	Belongs to the thiolase family
N8Z00_RS14525	COG1278	Cold shock
N8Z00_RS14530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N8Z00_RS14535	COG2373	Large extracellular alpha-helical protein
N8Z00_RS14540	COG4953	penicillin-binding protein 1C
N8Z00_RS14545	COG0542	response to heat
N8Z00_RS14550	COG2995	paraquat-inducible protein a
N8Z00_RS14555	COG3008	intermembrane lipid transfer
N8Z00_RS14565	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N8Z00_RS14565	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N8Z00_RS14565	COG0506	proline dehydrogenase activity
N8Z00_RS14595	COG2271	Major facilitator Superfamily
N8Z00_RS14615	COG1914	H( )-stimulated, divalent metal cation uptake system
N8Z00_RS14620	COG1764	response to oxidative stress
N8Z00_RS14630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS14635	COG0765	amino acid transport
N8Z00_RS14640	COG0765	amino acid transport
N8Z00_RS14645	COG1126	abc transporter atp-binding protein
N8Z00_RS14650	COG1902	pentaerythritol trinitrate reductase activity
N8Z00_RS14690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N8Z00_RS14695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N8Z00_RS14700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N8Z00_RS14705	COG0196	riboflavin kinase activity
N8Z00_RS14710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N8Z00_RS14715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N8Z00_RS14715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N8Z00_RS14730	COG0210	DNA helicase
N8Z00_RS14740	COG0488	(ABC) transporter
N8Z00_RS14745	COG2890	protein-(glutamine-N5) methyltransferase activity
N8Z00_RS14755	COG2171	N-acyltransferase activity
N8Z00_RS14775	COG2271	Major facilitator Superfamily
N8Z00_RS14780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N8Z00_RS14785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N8Z00_RS14790	COG0277	FAD linked oxidase domain protein
N8Z00_RS14805	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N8Z00_RS14815	COG0456	acetyltransferase
N8Z00_RS14820	COG3008	intermembrane lipid transfer
N8Z00_RS14855	COG0583	DNA-binding transcription factor activity
N8Z00_RS14885	COG1278	Cold shock
N8Z00_RS14895	COG1278	Cold shock
N8Z00_RS14905	COG0501	Belongs to the peptidase M48B family
N8Z00_RS14910	COG0544	peptidyl-prolyl cis-trans isomerase activity
N8Z00_RS14915	COG0740	serine-type endopeptidase activity
N8Z00_RS14920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N8Z00_RS14925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N8Z00_RS14930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N8Z00_RS14940	COG0556	nucleotide-excision repair
N8Z00_RS14945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N8Z00_RS14955	COG1104	cysteine desulfurase activity
N8Z00_RS14960	COG0822	iron-sulfur transferase activity
N8Z00_RS14965	COG0316	Belongs to the HesB IscA family
N8Z00_RS14970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N8Z00_RS14975	COG0443	Heat shock 70 kDa protein
N8Z00_RS14980	COG0633	Ferredoxin
N8Z00_RS14985	COG2975	iron-sulfur cluster assembly
N8Z00_RS14990	COG1803	Methylglyoxal synthase
N8Z00_RS15000	COG0583	DNA-binding transcription factor activity
N8Z00_RS15005	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS15010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS15050	COG1022	Amp-dependent synthetase and ligase
N8Z00_RS15060	COG1309	transcriptional regulator
N8Z00_RS15070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N8Z00_RS15075	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS15100	COG1136	(ABC) transporter
N8Z00_RS15105	COG0084	hydrolase, TatD family'
N8Z00_RS15110	COG4771	TonB-dependent receptor
N8Z00_RS15120	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS15125	COG4771	TonB-dependent receptor
N8Z00_RS15130	COG4607	ABC-type enterochelin transport system periplasmic component
N8Z00_RS15135	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N8Z00_RS15140	COG4605	iron ion homeostasis
N8Z00_RS15145	COG4604	ABC transporter, ATP-binding protein
N8Z00_RS15150	COG2814	Major facilitator Superfamily
N8Z00_RS15155	COG0737	Belongs to the 5'-nucleotidase family
N8Z00_RS15175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N8Z00_RS15185	COG0583	DNA-binding transcription factor activity
N8Z00_RS15190	COG1414	Transcriptional regulator
N8Z00_RS15195	COG2084	Dehydrogenase
N8Z00_RS15200	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS15210	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS15220	COG0439	Biotin carboxylase
N8Z00_RS15225	COG0511	ligase activity, forming carbon-carbon bonds
N8Z00_RS15230	COG1024	Enoyl-CoA hydratase
N8Z00_RS15230	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS15250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N8Z00_RS15270	COG0559	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS15300	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS15305	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS15345	COG0601	transmembrane transport
N8Z00_RS15350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS15355	COG0444	Belongs to the ABC transporter superfamily
N8Z00_RS15360	COG4608	Belongs to the ABC transporter superfamily
N8Z00_RS15390	COG1850	ribulose-bisphosphate carboxylase activity
N8Z00_RS15400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8Z00_RS15405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N8Z00_RS15415	COG1846	Transcriptional regulator
N8Z00_RS15425	COG3707	response regulator
N8Z00_RS15435	COG0515	serine threonine protein kinase
N8Z00_RS15445	COG2146	nitrite reductase [NAD(P)H] activity
N8Z00_RS15445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N8Z00_RS15450	COG2146	nitrite reductase [NAD(P)H] activity
N8Z00_RS15450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N8Z00_RS15480	COG0583	DNA-binding transcription factor activity
N8Z00_RS15490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N8Z00_RS15500	COG0613	PHP domain protein
N8Z00_RS15510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N8Z00_RS15515	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N8Z00_RS15515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8Z00_RS15525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N8Z00_RS15525	COG0047	phosphoribosylformylglycinamidine synthase activity
N8Z00_RS15530	COG0583	DNA-binding transcription factor activity
N8Z00_RS15535	COG0840	transmembrane signaling receptor activity
N8Z00_RS15540	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS15550	COG0583	DNA-binding transcription factor activity
N8Z00_RS15565	COG0657	acetylesterase activity
N8Z00_RS15570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N8Z00_RS15580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N8Z00_RS15590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N8Z00_RS15600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8Z00_RS15655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS15665	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
N8Z00_RS15670	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS15680	COG0559	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS15700	COG3386	PFAM SMP-30 Gluconolaconase
N8Z00_RS15715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS15730	COG2301	Belongs to the HpcH HpaI aldolase family
N8Z00_RS15735	COG1802	Transcriptional regulator
N8Z00_RS15760	COG3971	2-oxopent-4-enoate hydratase activity
N8Z00_RS15765	COG0179	Fumarylacetoacetate (FAA) hydrolase
N8Z00_RS15785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N8Z00_RS15790	COG1414	Transcriptional regulator
N8Z00_RS15855	COG0747	negative chemotaxis
N8Z00_RS15860	COG4608	Belongs to the ABC transporter superfamily
N8Z00_RS15865	COG0444	Belongs to the ABC transporter superfamily
N8Z00_RS15870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS15875	COG0601	transmembrane transport
N8Z00_RS15880	COG2072	flavoprotein involved in K transport
N8Z00_RS15905	COG0288	reversible hydration of carbon dioxide
N8Z00_RS15910	COG0633	Ferredoxin
N8Z00_RS15965	COG0653	protein targeting
N8Z00_RS15970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N8Z00_RS15980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N8Z00_RS15990	COG0583	DNA-binding transcription factor activity
N8Z00_RS16015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N8Z00_RS16015	COG0519	Catalyzes the synthesis of GMP from XMP
N8Z00_RS16040	COG0583	DNA-binding transcription factor activity
N8Z00_RS16050	COG3311	Transcriptional regulator
N8Z00_RS16055	COG0789	Transcriptional regulator
N8Z00_RS16070	COG0625	glutathione transferase activity
N8Z00_RS16100	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS16115	COG0583	DNA-binding transcription factor activity
N8Z00_RS16130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N8Z00_RS16140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N8Z00_RS16145	COG5001	Diguanylate cyclase
N8Z00_RS16160	COG1902	pentaerythritol trinitrate reductase activity
N8Z00_RS16165	COG4221	oxidoreductase activity
N8Z00_RS16175	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS16180	COG1942	4-Oxalocrotonate Tautomerase
N8Z00_RS16185	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
N8Z00_RS16250	COG0477	Major facilitator Superfamily
N8Z00_RS16255	COG0583	DNA-binding transcription factor activity
N8Z00_RS16260	COG0154	amidase activity
N8Z00_RS16265	COG0840	transmembrane signaling receptor activity
N8Z00_RS16270	COG0835	chemotaxis
N8Z00_RS16295	COG5001	Diguanylate cyclase
N8Z00_RS16295	COG2203	Gaf domain
N8Z00_RS16295	COG3706	GGDEF domain
N8Z00_RS16295	COG4251	negative regulation of phosphorylation
N8Z00_RS16325	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS16330	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS16335	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS16340	COG0183	Belongs to the thiolase family
N8Z00_RS16345	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS16345	COG1024	Enoyl-CoA hydratase
N8Z00_RS16350	COG0583	DNA-binding transcription factor activity
N8Z00_RS16355	COG0628	permease
N8Z00_RS16360	COG2733	membrane
N8Z00_RS16365	COG2032	superoxide dismutase activity
N8Z00_RS16395	COG2885	chlorophyll binding
N8Z00_RS16420	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N8Z00_RS16430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8Z00_RS16450	COG1846	Transcriptional regulator
N8Z00_RS16460	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS16495	COG0697	spore germination
N8Z00_RS16505	COG4941	Belongs to the sigma-70 factor family
N8Z00_RS16515	COG3795	YCII-related domain
N8Z00_RS16520	COG1487	ribonuclease activity
N8Z00_RS16525	COG4691	Plasmid stability protein
N8Z00_RS16530	COG3795	YCII-related domain
N8Z00_RS16535	COG1360	Flagellar Motor Protein
N8Z00_RS16540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N8Z00_RS16550	COG2207	Transcriptional regulator
N8Z00_RS16560	COG1683	Conserved Protein
N8Z00_RS16575	COG1309	transcriptional regulator
N8Z00_RS16585	COG4608	Belongs to the ABC transporter superfamily
N8Z00_RS16590	COG0444	Belongs to the ABC transporter superfamily
N8Z00_RS16595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS16600	COG0601	transmembrane transport
N8Z00_RS16605	COG0747	negative chemotaxis
N8Z00_RS16610	COG1802	Transcriptional regulator
N8Z00_RS16615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N8Z00_RS16625	COG0667	Aldo Keto reductase
N8Z00_RS16635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N8Z00_RS16640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N8Z00_RS16660	COG1414	Transcriptional regulator
N8Z00_RS16665	COG2764	glyoxalase bleomycin resistance protein dioxygenase
N8Z00_RS16685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N8Z00_RS16695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS16700	COG0765	amino acid transport
N8Z00_RS16705	COG0765	amino acid transport
N8Z00_RS16735	COG0587	DNA-directed DNA polymerase activity
N8Z00_RS16750	COG0833	amino acid
N8Z00_RS16755	COG0400	carboxylic ester hydrolase activity
N8Z00_RS16765	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS16775	COG0028	Belongs to the TPP enzyme family
N8Z00_RS16785	COG1538	Outer membrane efflux protein
N8Z00_RS16790	COG1566	PFAM secretion protein HlyD family protein
N8Z00_RS16810	COG0720	synthase
N8Z00_RS16815	COG0602	queuosine metabolic process
N8Z00_RS16830	COG1902	pentaerythritol trinitrate reductase activity
N8Z00_RS16850	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
N8Z00_RS16890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N8Z00_RS16905	COG0842	Transport permease protein
N8Z00_RS16910	COG1131	(ABC) transporter
N8Z00_RS16920	COG1309	transcriptional regulator
N8Z00_RS16925	COG2130	NADP-dependent
N8Z00_RS16950	COG3842	ATPase activity
N8Z00_RS16955	COG3842	ATPase activity
N8Z00_RS16965	COG0395	ABC-type sugar transport system, permease component
N8Z00_RS16995	COG3634	alkyl hydroperoxide reductase activity
N8Z00_RS17000	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS17030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8Z00_RS17035	COG0420	3'-5' exonuclease activity
N8Z00_RS17060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N8Z00_RS17060	COG2111	Na H antiporter
N8Z00_RS17065	COG1006	Multisubunit Na H antiporter MnhC subunit
N8Z00_RS17070	COG0651	ATP synthesis coupled electron transport
N8Z00_RS17075	COG1863	multisubunit Na H antiporter MnhE subunit
N8Z00_RS17080	COG2212	antiporter activity
N8Z00_RS17100	COG0590	tRNA wobble adenosine to inosine editing
N8Z00_RS17105	COG1619	proteins homologs of microcin C7 resistance protein MccF
N8Z00_RS17110	COG0488	(ABC) transporter
N8Z00_RS17120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N8Z00_RS17140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N8Z00_RS17145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N8Z00_RS17155	COG2252	PERMEase
N8Z00_RS17160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N8Z00_RS17165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N8Z00_RS17175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N8Z00_RS17205	COG0583	DNA-binding transcription factor activity
N8Z00_RS17210	COG2814	Major facilitator Superfamily
N8Z00_RS17215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N8Z00_RS17220	COG0789	Transcriptional regulator
N8Z00_RS17235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N8Z00_RS17235	COG0678	peroxiredoxin activity
N8Z00_RS17245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N8Z00_RS17250	COG0584	glycerophosphoryl diester phosphodiesterase
N8Z00_RS17255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N8Z00_RS17265	COG4181	ATPase activity
N8Z00_RS17285	COG0583	DNA-binding transcription factor activity
N8Z00_RS17300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8Z00_RS17315	COG4336	lyase activity
N8Z00_RS17320	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N8Z00_RS17360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS17365	COG0765	amino acid transport
N8Z00_RS17370	COG1126	abc transporter atp-binding protein
N8Z00_RS17375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N8Z00_RS17380	COG1758	RNA polymerase activity
N8Z00_RS17385	COG0194	GDP metabolic process
N8Z00_RS17390	COG3258	Cytochrome c
N8Z00_RS17395	COG2863	cytochrome
N8Z00_RS17400	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS17405	COG0791	NLP P60 protein
N8Z00_RS17420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N8Z00_RS17425	COG0833	amino acid
N8Z00_RS17430	COG0583	DNA-binding transcription factor activity
N8Z00_RS17440	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N8Z00_RS17450	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS17465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N8Z00_RS17470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N8Z00_RS17475	COG0174	glutamine synthetase
N8Z00_RS17485	COG2204	response regulator
N8Z00_RS17495	COG0583	DNA-binding transcription factor activity
N8Z00_RS17500	COG1741	Belongs to the pirin family
N8Z00_RS17505	COG1741	Belongs to the pirin family
N8Z00_RS17510	COG3842	ATPase activity
N8Z00_RS17520	COG1840	ABC-type Fe3 transport system, periplasmic component
N8Z00_RS17555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N8Z00_RS17560	COG0583	DNA-binding transcription factor activity
N8Z00_RS17565	COG0783	Belongs to the Dps family
N8Z00_RS17570	COG0300	oxidoreductase activity
N8Z00_RS17610	COG0463	Glycosyl transferase, family 2
N8Z00_RS17625	COG0156	8-amino-7-oxononanoate synthase activity
N8Z00_RS17630	COG0604	alcohol dehydrogenase
N8Z00_RS17630	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS17630	COG3321	synthase
N8Z00_RS17645	COG3842	ATPase activity
N8Z00_RS17650	COG0395	ABC-type sugar transport system, permease component
N8Z00_RS17655	COG1175	transmembrane transport
N8Z00_RS17660	COG1653	transport
N8Z00_RS17670	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N8Z00_RS17680	COG0559	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS17700	COG1794	racemase activity, acting on amino acids and derivatives
N8Z00_RS17705	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
N8Z00_RS17720	COG0625	glutathione transferase activity
N8Z00_RS17725	COG2133	pyrroloquinoline quinone binding
N8Z00_RS17735	COG0697	spore germination
N8Z00_RS17740	COG2363	Small membrane protein
N8Z00_RS17770	COG0010	Belongs to the arginase family
N8Z00_RS17775	COG1464	Belongs to the NlpA lipoprotein family
N8Z00_RS17790	COG1408	metallophosphoesterase
N8Z00_RS17800	COG0688	phosphatidylethanolamine metabolic process
N8Z00_RS17805	COG0488	(ABC) transporter
N8Z00_RS17830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8Z00_RS17835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N8Z00_RS17840	COG2199	diguanylate cyclase activity
N8Z00_RS17840	COG2203	Gaf domain
N8Z00_RS17840	COG2200	EAL domain
N8Z00_RS17855	COG2814	Major facilitator Superfamily
N8Z00_RS17880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
N8Z00_RS17885	COG2204	response regulator
N8Z00_RS17915	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS17955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N8Z00_RS17965	COG1289	transmembrane transporter activity
N8Z00_RS17970	COG2199	diguanylate cyclase activity
N8Z00_RS17970	COG2200	EAL domain
N8Z00_RS17985	COG2863	cytochrome
N8Z00_RS18005	COG1253	flavin adenine dinucleotide binding
N8Z00_RS18015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N8Z00_RS18020	COG0714	Associated with various cellular activities
N8Z00_RS18065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N8Z00_RS18090	COG1024	Enoyl-CoA hydratase
N8Z00_RS18090	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS18105	COG2807	transmembrane transport
N8Z00_RS18110	COG1846	Transcriptional regulator
N8Z00_RS18135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N8Z00_RS18160	COG0628	permease
N8Z00_RS18170	COG1619	proteins homologs of microcin C7 resistance protein MccF
N8Z00_RS18185	COG1959	2 iron, 2 sulfur cluster binding
N8Z00_RS18190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N8Z00_RS18195	COG0531	amino acid
N8Z00_RS18215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N8Z00_RS18225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N8Z00_RS18225	COG1793	dna ligase
N8Z00_RS18230	COG1793	dna ligase
N8Z00_RS18235	COG1201	RNA secondary structure unwinding
N8Z00_RS18260	COG2010	Cytochrome c
N8Z00_RS18260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N8Z00_RS18265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N8Z00_RS18290	COG0179	Fumarylacetoacetate (FAA) hydrolase
N8Z00_RS18315	COG2146	nitrite reductase [NAD(P)H] activity
N8Z00_RS18330	COG3971	2-oxopent-4-enoate hydratase activity
N8Z00_RS18340	COG0431	NADPH-dependent FMN reductase
N8Z00_RS18355	COG2072	flavoprotein involved in K transport
N8Z00_RS18365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N8Z00_RS18370	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N8Z00_RS18380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N8Z00_RS18385	COG2197	response regulator
N8Z00_RS18400	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
N8Z00_RS18405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N8Z00_RS18415	COG0589	response to stress
N8Z00_RS18425	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS18430	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS18435	COG2084	Dehydrogenase
N8Z00_RS18440	COG0583	DNA-binding transcription factor activity
N8Z00_RS18495	COG0583	DNA-binding transcription factor activity
N8Z00_RS18500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N8Z00_RS18530	COG0028	Belongs to the TPP enzyme family
N8Z00_RS18530	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
N8Z00_RS18570	COG3048	D-serine ammonia-lyase activity
N8Z00_RS18575	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS18580	COG0154	amidase activity
N8Z00_RS18595	COG1309	transcriptional regulator
N8Z00_RS18640	COG4770	biotin carboxylase activity
N8Z00_RS18645	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N8Z00_RS18650	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N8Z00_RS18685	COG3568	Endonuclease Exonuclease Phosphatase
N8Z00_RS18690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N8Z00_RS18715	COG0028	Belongs to the TPP enzyme family
N8Z00_RS18720	COG0297	glycogen (starch) synthase activity
N8Z00_RS18725	COG0366	Alpha amylase catalytic
N8Z00_RS18730	COG0366	Alpha amylase catalytic
N8Z00_RS18735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N8Z00_RS18745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N8Z00_RS18760	COG4773	Receptor
N8Z00_RS18765	COG1408	metallophosphoesterase
N8Z00_RS18805	COG0747	negative chemotaxis
N8Z00_RS18815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS18820	COG0444	Belongs to the ABC transporter superfamily
N8Z00_RS18835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N8Z00_RS18845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8Z00_RS18845	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N8Z00_RS18855	COG0028	Belongs to the TPP enzyme family
N8Z00_RS18865	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS18875	COG3609	addiction module antidote protein, CC2985 family
N8Z00_RS18910	COG1335	isochorismatase
N8Z00_RS18920	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
N8Z00_RS18940	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS18945	COG3386	PFAM SMP-30 Gluconolaconase
N8Z00_RS18950	COG2721	sulfolactate sulfo-lyase activity
N8Z00_RS18970	COG4774	siderophore transport
N8Z00_RS18985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N8Z00_RS19000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8Z00_RS19005	COG0436	Aminotransferase
N8Z00_RS19010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N8Z00_RS19025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N8Z00_RS19040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
N8Z00_RS19045	COG1126	abc transporter atp-binding protein
N8Z00_RS19050	COG0765	amino acid transport
N8Z00_RS19055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS19060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N8Z00_RS19100	COG0583	DNA-binding transcription factor activity
N8Z00_RS19120	COG4566	intracellular signal transduction
N8Z00_RS19135	COG3706	GGDEF domain
N8Z00_RS19140	COG0667	Aldo Keto reductase
N8Z00_RS19155	COG1304	FMN binding
N8Z00_RS19170	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS19185	COG0251	oxidation-reduction process
N8Z00_RS19200	COG3119	arylsulfatase activity
N8Z00_RS19205	COG0583	DNA-binding transcription factor activity
N8Z00_RS19220	COG3119	arylsulfatase activity
N8Z00_RS19225	COG3706	GGDEF domain
N8Z00_RS19245	COG4948	Mandelate Racemase Muconate Lactonizing
N8Z00_RS19260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N8Z00_RS19275	COG0583	DNA-binding transcription factor activity
N8Z00_RS19280	COG0861	Integral membrane protein TerC family
N8Z00_RS19305	COG0583	DNA-binding transcription factor activity
N8Z00_RS19325	COG5295	Hep Hag repeat protein
N8Z00_RS19330	COG1763	Mo-molybdopterin cofactor biosynthetic process
N8Z00_RS19360	COG0583	DNA-binding transcription factor activity
N8Z00_RS19395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8Z00_RS19415	COG2070	2-Nitropropane dioxygenase
N8Z00_RS19420	COG5002	protein histidine kinase activity
N8Z00_RS19425	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS19430	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
N8Z00_RS19435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N8Z00_RS19445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N8Z00_RS19450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N8Z00_RS19480	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS19485	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS19490	COG3275	phosphorelay sensor kinase activity
N8Z00_RS19495	COG3279	Response regulator of the LytR AlgR family
N8Z00_RS19500	COG0583	DNA-binding transcription factor activity
N8Z00_RS19505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS19510	COG1024	Enoyl-CoA hydratase
N8Z00_RS19515	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS19520	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS19545	COG0583	DNA-binding transcription factor activity
N8Z00_RS19585	COG1595	DNA-templated transcription, initiation
N8Z00_RS19630	COG0583	DNA-binding transcription factor activity
N8Z00_RS19645	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS19660	COG0583	DNA-binding transcription factor activity
N8Z00_RS19735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N8Z00_RS19755	COG1733	regulation of RNA biosynthetic process
N8Z00_RS19780	COG3038	cytochrome b561
N8Z00_RS19790	COG0384	phenazine biosynthesis protein PhzF
N8Z00_RS19820	COG2985	domain, Protein
N8Z00_RS19830	COG1566	PFAM secretion protein HlyD family protein
N8Z00_RS19850	COG2985	domain, Protein
N8Z00_RS19860	COG0668	transmembrane transport
N8Z00_RS19890	COG0583	DNA-binding transcription factor activity
N8Z00_RS19900	COG1473	amidohydrolase
N8Z00_RS19905	COG0523	cobalamin synthesis protein
N8Z00_RS19910	COG1126	abc transporter atp-binding protein
N8Z00_RS19915	COG0765	amino acid transport
N8Z00_RS19920	COG4597	amino acid ABC transporter
N8Z00_RS19925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS19930	COG0626	cystathionine gamma-synthase activity
N8Z00_RS19935	COG0583	DNA-binding transcription factor activity
N8Z00_RS19945	COG0640	Transcriptional regulator
N8Z00_RS19965	COG1309	transcriptional regulator
N8Z00_RS19980	COG0583	DNA-binding transcription factor activity
N8Z00_RS19985	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
N8Z00_RS19990	COG1846	Transcriptional regulator
N8Z00_RS20000	COG0583	DNA-binding transcription factor activity
N8Z00_RS20005	COG1335	isochorismatase
N8Z00_RS20015	COG2207	Transcriptional regulator
N8Z00_RS20020	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS20050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N8Z00_RS20065	COG4521	taurine ABC transporter
N8Z00_RS20070	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
N8Z00_RS20075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8Z00_RS20105	COG1414	Transcriptional regulator
N8Z00_RS20110	COG0513	Belongs to the DEAD box helicase family
N8Z00_RS20115	COG2259	Doxx family
N8Z00_RS20135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS20160	COG0386	Belongs to the glutathione peroxidase family
N8Z00_RS20165	COG1522	sequence-specific DNA binding
N8Z00_RS20175	COG0625	glutathione transferase activity
N8Z00_RS20200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N8Z00_RS20210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N8Z00_RS20215	COG0010	Belongs to the arginase family
N8Z00_RS20220	COG1126	abc transporter atp-binding protein
N8Z00_RS20225	COG0765	amino acid transport
N8Z00_RS20230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS20245	COG0084	hydrolase, TatD family'
N8Z00_RS20250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N8Z00_RS20255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N8Z00_RS20260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N8Z00_RS20285	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS20285	COG1024	Enoyl-CoA hydratase
N8Z00_RS20290	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS20295	COG2914	Belongs to the UPF0125 (RnfH) family
N8Z00_RS20300	COG2867	negative regulation of translational initiation
N8Z00_RS20305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N8Z00_RS20325	COG0519	Catalyzes the synthesis of GMP from XMP
N8Z00_RS20325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N8Z00_RS20330	COG2169	Transcriptional regulator
N8Z00_RS20330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N8Z00_RS20355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N8Z00_RS20360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N8Z00_RS20375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N8Z00_RS20380	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N8Z00_RS20385	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
N8Z00_RS20390	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N8Z00_RS20395	COG0750	zinc metalloprotease
N8Z00_RS20400	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N8Z00_RS20405	COG0575	Belongs to the CDS family
N8Z00_RS20410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N8Z00_RS20415	COG0233	cytoplasmic translational termination
N8Z00_RS20420	COG0528	UMP kinase activity
N8Z00_RS20425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N8Z00_RS20430	COG0052	Belongs to the universal ribosomal protein uS2 family
N8Z00_RS20435	COG0024	Methionine aminopeptidase
N8Z00_RS20440	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N8Z00_RS20450	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N8Z00_RS20455	COG1451	nucleotide metabolic process
N8Z00_RS20460	COG2186	Transcriptional regulator
N8Z00_RS20465	COG0277	FAD linked oxidase domain protein
N8Z00_RS20475	COG1286	toxin biosynthetic process
N8Z00_RS20485	COG0285	dihydrofolate synthase activity
N8Z00_RS20500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS20520	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N8Z00_RS20540	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N8Z00_RS20550	COG1677	Flagellar hook-basal body complex protein FliE
N8Z00_RS20555	COG1766	The M ring may be actively involved in energy transduction
N8Z00_RS20560	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N8Z00_RS20565	COG1317	bacterial-type flagellum organization
N8Z00_RS20585	COG1580	Controls the rotational direction of flagella during chemotaxis
N8Z00_RS20610	COG1987	bacterial-type flagellum assembly
N8Z00_RS20620	COG0840	transmembrane signaling receptor activity
N8Z00_RS20645	COG0840	transmembrane signaling receptor activity
N8Z00_RS20680	COG4787	bacterial-type flagellum-dependent cell motility
N8Z00_RS20695	COG1558	bacterial-type flagellum-dependent cell motility
N8Z00_RS20700	COG1815	bacterial-type flagellum-dependent cell motility
N8Z00_RS20710	COG2747	anti-sigma28 factor FlgM
N8Z00_RS20725	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N8Z00_RS20735	COG0840	transmembrane signaling receptor activity
N8Z00_RS20740	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
N8Z00_RS20745	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS20750	COG2201	protein-glutamate methylesterase activity
N8Z00_RS20755	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N8Z00_RS20760	COG0840	transmembrane signaling receptor activity
N8Z00_RS20765	COG0835	chemotaxis
N8Z00_RS20775	COG2204	response regulator
N8Z00_RS20830	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
N8Z00_RS20865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N8Z00_RS20870	COG0508	dehydrogenase complex catalyzes the overall conversion of
N8Z00_RS20885	COG4566	intracellular signal transduction
N8Z00_RS20890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N8Z00_RS20895	COG0339	signal peptide processing
N8Z00_RS20910	COG1999	signal sequence binding
N8Z00_RS20915	COG2261	transglycosylase associated protein
N8Z00_RS20935	COG0583	DNA-binding transcription factor activity
N8Z00_RS20940	COG1187	pseudouridine synthase activity
N8Z00_RS20985	COG3161	chorismate lyase activity
N8Z00_RS21005	COG1335	isochorismatase
N8Z00_RS21020	COG0066	3-isopropylmalate dehydratase activity
N8Z00_RS21025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N8Z00_RS21055	COG2188	Transcriptional regulator
N8Z00_RS21080	COG1309	transcriptional regulator
N8Z00_RS21090	COG0523	cobalamin synthesis protein
N8Z00_RS21095	COG1335	isochorismatase
N8Z00_RS21100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N8Z00_RS21105	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N8Z00_RS21110	COG1802	Transcriptional regulator
N8Z00_RS21115	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N8Z00_RS21125	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS21130	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS21145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N8Z00_RS21150	COG0436	Aminotransferase
N8Z00_RS21160	COG0765	amino acid transport
N8Z00_RS21195	COG0583	DNA-binding transcription factor activity
N8Z00_RS21215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8Z00_RS21230	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
N8Z00_RS21260	COG0604	alcohol dehydrogenase
N8Z00_RS21265	COG1733	regulation of RNA biosynthetic process
N8Z00_RS21275	COG3712	iron ion homeostasis
N8Z00_RS21280	COG1595	DNA-templated transcription, initiation
N8Z00_RS21290	COG0165	Argininosuccinate lyase
N8Z00_RS21305	COG0625	glutathione transferase activity
N8Z00_RS21320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS21325	COG2301	Belongs to the HpcH HpaI aldolase family
N8Z00_RS21330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N8Z00_RS21350	COG1335	isochorismatase
N8Z00_RS21375	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS21390	COG0642	Histidine kinase
N8Z00_RS21400	COG4221	oxidoreductase activity
N8Z00_RS21410	COG4681	YaeQ
N8Z00_RS21420	COG4172	Belongs to the ABC transporter superfamily
N8Z00_RS21425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS21430	COG0601	transmembrane transport
N8Z00_RS21435	COG0747	negative chemotaxis
N8Z00_RS21445	COG0583	DNA-binding transcription factor activity
N8Z00_RS21485	COG0583	DNA-binding transcription factor activity
N8Z00_RS21490	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS21510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N8Z00_RS21515	COG0277	FAD linked oxidase domain protein
N8Z00_RS21535	COG2165	general secretion pathway protein
N8Z00_RS21595	COG0668	transmembrane transport
N8Z00_RS21600	COG0165	Argininosuccinate lyase
N8Z00_RS21605	COG1598	PFAM Uncharacterised protein family UPF0150
N8Z00_RS21625	COG0022	dehydrogenase e1 component
N8Z00_RS21640	COG0789	Transcriptional regulator
N8Z00_RS21650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N8Z00_RS21655	COG1414	Transcriptional regulator
N8Z00_RS21660	COG0235	Class ii aldolase
N8Z00_RS21665	COG2808	Putative FMN-binding domain
N8Z00_RS21670	COG0657	acetylesterase activity
N8Z00_RS21685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS21690	COG0601	transmembrane transport
N8Z00_RS21695	COG0747	negative chemotaxis
N8Z00_RS21710	COG0307	riboflavin synthase, alpha
N8Z00_RS21715	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS21720	COG2186	Transcriptional regulator
N8Z00_RS21755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N8Z00_RS21780	COG0583	DNA-binding transcription factor activity
N8Z00_RS21810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8Z00_RS21825	COG1132	(ABC) transporter
N8Z00_RS21840	COG5265	(ABC) transporter
N8Z00_RS21850	COG4977	sequence-specific DNA binding
N8Z00_RS21870	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS21875	COG2188	Transcriptional regulator
N8Z00_RS21890	COG0583	DNA-binding transcription factor activity
N8Z00_RS21895	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS21905	COG1024	Enoyl-CoA hydratase
N8Z00_RS21910	COG5001	Diguanylate cyclase
N8Z00_RS21915	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS21920	COG0129	dihydroxy-acid dehydratase activity
N8Z00_RS21930	COG0583	DNA-binding transcription factor activity
N8Z00_RS21935	COG1250	3-hydroxyacyl-CoA dehydrogenase
N8Z00_RS21940	COG3246	L-lysine catabolic process to acetate
N8Z00_RS21960	COG3043	anaerobic respiration
N8Z00_RS21965	COG3005	denitrification pathway
N8Z00_RS21970	COG4133	protoheme IX ABC transporter activity
N8Z00_RS21990	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
N8Z00_RS22000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N8Z00_RS22010	COG4235	cytochrome complex assembly
N8Z00_RS22040	COG2226	methyltransferase
N8Z00_RS22050	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
N8Z00_RS22055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N8Z00_RS22065	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS22070	COG1024	Enoyl-CoA hydratase
N8Z00_RS22085	COG0697	spore germination
N8Z00_RS22090	COG0697	spore germination
N8Z00_RS22110	COG1280	lysine exporter protein (LysE YggA)
N8Z00_RS22125	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N8Z00_RS22145	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS22150	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS22155	COG2814	Major facilitator Superfamily
N8Z00_RS22170	COG0625	glutathione transferase activity
N8Z00_RS22175	COG0583	DNA-binding transcription factor activity
N8Z00_RS22180	COG0583	DNA-binding transcription factor activity
N8Z00_RS22185	COG2814	Major facilitator Superfamily
N8Z00_RS22205	COG0506	proline dehydrogenase activity
N8Z00_RS22210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8Z00_RS22215	COG1959	2 iron, 2 sulfur cluster binding
N8Z00_RS22240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N8Z00_RS22245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N8Z00_RS22255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N8Z00_RS22295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N8Z00_RS22305	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS22310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N8Z00_RS22320	COG1610	YqeY-like protein
N8Z00_RS22350	COG2223	nitrite transmembrane transporter activity
N8Z00_RS22365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N8Z00_RS22385	COG5265	(ABC) transporter
N8Z00_RS22400	COG0583	DNA-binding transcription factor activity
N8Z00_RS22415	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS22450	COG1522	sequence-specific DNA binding
N8Z00_RS22470	COG2988	succinylglutamate desuccinylase activity
N8Z00_RS22475	COG0456	acetyltransferase
N8Z00_RS22480	COG0384	phenazine biosynthesis protein PhzF
N8Z00_RS22650	COG0072	phenylalanine-tRNA ligase activity
N8Z00_RS22650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N8Z00_RS22655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N8Z00_RS22660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N8Z00_RS22665	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N8Z00_RS22675	COG2960	long-chain fatty acid transporting porin activity
N8Z00_RS22685	COG0347	Belongs to the P(II) protein family
N8Z00_RS22690	COG0004	ammonium transporteR
N8Z00_RS22695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N8Z00_RS22700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N8Z00_RS22715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N8Z00_RS22720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N8Z00_RS22725	COG2197	response regulator
N8Z00_RS22730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N8Z00_RS22750	COG0747	negative chemotaxis
N8Z00_RS22755	COG0601	transmembrane transport
N8Z00_RS22760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS22765	COG4172	Belongs to the ABC transporter superfamily
N8Z00_RS22785	COG1609	Transcriptional regulator
N8Z00_RS22790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N8Z00_RS22795	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8Z00_RS22800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N8Z00_RS22805	COG0129	dihydroxy-acid dehydratase activity
N8Z00_RS22845	COG0135	phosphoribosylanthranilate isomerase activity
N8Z00_RS22850	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N8Z00_RS22855	COG0101	tRNA pseudouridine synthase activity
N8Z00_RS22870	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N8Z00_RS22890	COG1538	Outer membrane efflux protein
N8Z00_RS22940	COG4783	chaperone-mediated protein folding
N8Z00_RS22960	COG2205	protein histidine kinase activity
N8Z00_RS22970	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N8Z00_RS22980	COG1295	ribonuclease BN
N8Z00_RS22990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N8Z00_RS23020	COG4964	Belongs to the GSP D family
N8Z00_RS23075	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N8Z00_RS23080	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N8Z00_RS23085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N8Z00_RS23090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
N8Z00_RS23095	COG0330	HflC and HflK could
N8Z00_RS23100	COG0330	HflC and HflK could
N8Z00_RS23105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N8Z00_RS23110	COG1923	regulation of RNA biosynthetic process
N8Z00_RS23115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N8Z00_RS23120	COG1160	GTP binding
N8Z00_RS23125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N8Z00_RS23130	COG2976	Protein conserved in bacteria
N8Z00_RS23150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N8Z00_RS23155	COG0105	UTP biosynthetic process
N8Z00_RS23160	COG0525	valine-tRNA ligase activity
N8Z00_RS23165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8Z00_RS23170	COG1126	abc transporter atp-binding protein
N8Z00_RS23175	COG0765	amino acid transport
N8Z00_RS23180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8Z00_RS23185	COG1396	sequence-specific DNA binding
N8Z00_RS23190	COG0336	Belongs to the RNA methyltransferase TrmD family
N8Z00_RS23195	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N8Z00_RS23200	COG0228	four-way junction DNA binding
N8Z00_RS23210	COG0425	Belongs to the sulfur carrier protein TusA family
N8Z00_RS23215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N8Z00_RS23265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8Z00_RS23280	COG2076	Multidrug Resistance protein
N8Z00_RS23285	COG3217	Mosc domain protein beta barrel domain protein
N8Z00_RS23285	COG0633	Ferredoxin
N8Z00_RS23290	COG5285	phytanoyl-CoA dioxygenase
N8Z00_RS23295	COG0662	Cupin 2, conserved barrel domain protein
N8Z00_RS23320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N8Z00_RS23325	COG2311	Membrane
N8Z00_RS23340	COG0187	DNA topoisomerase II activity
N8Z00_RS23350	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N8Z00_RS23360	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N8Z00_RS23365	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N8Z00_RS23385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N8Z00_RS23395	COG3391	amine dehydrogenase activity
N8Z00_RS23435	COG1566	PFAM secretion protein HlyD family protein
N8Z00_RS23440	COG2814	Major facilitator Superfamily
N8Z00_RS23450	COG0473	3-isopropylmalate dehydrogenase activity
N8Z00_RS23455	COG0433	COG0433 Predicted ATPase
N8Z00_RS23460	COG0217	transcriptional regulatory protein
N8Z00_RS23465	COG0151	Belongs to the GarS family
N8Z00_RS23475	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N8Z00_RS23480	COG0799	negative regulation of ribosome biogenesis
N8Z00_RS23485	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N8Z00_RS23495	COG1301	dicarboxylic acid transport
N8Z00_RS23500	COG4191	Histidine kinase
N8Z00_RS23505	COG2204	response regulator
N8Z00_RS23535	COG1530	ribonuclease E activity
N8Z00_RS23545	COG4251	negative regulation of phosphorylation
N8Z00_RS23545	COG2203	Gaf domain
N8Z00_RS23545	COG5001	Diguanylate cyclase
N8Z00_RS23545	COG3706	GGDEF domain
N8Z00_RS23555	COG0475	glutathione-regulated potassium exporter activity
N8Z00_RS23555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N8Z00_RS23560	COG1132	(ABC) transporter
N8Z00_RS23585	COG0726	polysaccharide deacetylase
N8Z00_RS23590	COG0438	transferase activity, transferring glycosyl groups
N8Z00_RS23600	COG0726	polysaccharide deacetylase
N8Z00_RS23605	COG0438	transferase activity, transferring glycosyl groups
N8Z00_RS23620	COG1643	Atp-dependent helicase
N8Z00_RS23625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N8Z00_RS23625	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N8Z00_RS23630	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
N8Z00_RS23640	COG0704	Plays a role in the regulation of phosphate uptake
N8Z00_RS23645	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N8Z00_RS23650	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS23670	COG2094	Belongs to the DNA glycosylase MPG family
N8Z00_RS23680	COG1177	transmembrane transport
N8Z00_RS23685	COG1176	ABC-type spermidine putrescine transport system, permease component I
N8Z00_RS23690	COG3842	ATPase activity
N8Z00_RS23695	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N8Z00_RS23700	COG3642	lipopolysaccharide core region biosynthetic process
N8Z00_RS23710	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
N8Z00_RS23715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N8Z00_RS23725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N8Z00_RS23725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8Z00_RS23730	COG4608	Belongs to the ABC transporter superfamily
N8Z00_RS23735	COG0444	Belongs to the ABC transporter superfamily
N8Z00_RS23755	COG0601	transmembrane transport
N8Z00_RS23760	COG0747	negative chemotaxis
N8Z00_RS23780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N8Z00_RS23785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N8Z00_RS23815	COG0583	DNA-binding transcription factor activity
N8Z00_RS23820	COG0137	argininosuccinate synthase activity
N8Z00_RS23825	COG3158	transport of potassium into the cell
N8Z00_RS23830	COG0642	Histidine kinase
N8Z00_RS24020	COG2197	response regulator
N8Z00_RS24130	COG1475	DNA binding
N8Z00_RS24145	COG0270	DNA (cytosine-5-)-methyltransferase activity
N8Z00_RS24170	COG0776	regulation of translation
N8Z00_RS24175	COG3128	pkhd-type hydroxylase
N8Z00_RS24180	COG0626	cystathionine gamma-synthase activity
N8Z00_RS24185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N8Z00_RS24190	COG0557	exoribonuclease II activity
N8Z00_RS24230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N8Z00_RS24235	COG2391	methyltransferase activity
N8Z00_RS24240	COG0069	glutamate synthase activity
N8Z00_RS24245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N8Z00_RS24260	COG1262	PFAM Formylglycine-generating sulfatase enzyme
N8Z00_RS24290	COG0697	spore germination
N8Z00_RS24310	COG0628	permease
N8Z00_RS24335	COG3909	cytochrome
N8Z00_RS24345	COG0625	glutathione transferase activity
N8Z00_RS24350	COG0730	response to heat
N8Z00_RS24355	COG0482	sulfurtransferase activity
N8Z00_RS24360	COG0583	DNA-binding transcription factor activity
N8Z00_RS24390	COG0247	lactate metabolic process
N8Z00_RS24395	COG0277	FAD linked oxidase domain protein
N8Z00_RS24400	COG0277	FAD linked oxidase domain protein
N8Z00_RS24405	COG0277	FAD linked oxidase domain protein
N8Z00_RS24410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N8Z00_RS24415	COG0312	modulator of DNA gyrase
N8Z00_RS24430	COG0308	aminopeptidase N
N8Z00_RS24435	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N8Z00_RS24455	COG0436	Aminotransferase
N8Z00_RS24465	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N8Z00_RS24470	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N8Z00_RS24490	COG0559	Belongs to the binding-protein-dependent transport system permease family
N8Z00_RS24505	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS24520	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS24530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N8Z00_RS24550	COG0181	hydroxymethylbilane synthase activity
N8Z00_RS24555	COG0861	Integral membrane protein TerC family
N8Z00_RS24560	COG0861	Integral membrane protein TerC family
N8Z00_RS24565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N8Z00_RS24570	COG0045	succinate-CoA ligase (ADP-forming) activity
N8Z00_RS24590	COG2137	regulation of response to DNA damage stimulus
N8Z00_RS24595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N8Z00_RS24630	COG0540	Belongs to the ATCase OTCase family
N8Z00_RS24660	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
N8Z00_RS24680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N8Z00_RS24715	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N8Z00_RS24725	COG0305	Participates in initiation and elongation during chromosome replication
N8Z00_RS24735	COG0359	binds to the 23S rRNA
N8Z00_RS24740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N8Z00_RS24745	COG2965	DNA replication, synthesis of RNA primer
N8Z00_RS24750	COG0360	Binds together with S18 to 16S ribosomal RNA
N8Z00_RS24755	COG3739	integral membrane protein
N8Z00_RS24760	COG1469	GTP cyclohydrolase I activity
N8Z00_RS24770	COG0142	geranyltranstransferase activity
N8Z00_RS24775	COG1722	exodeoxyribonuclease VII activity
N8Z00_RS24785	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS24800	COG0492	ferredoxin-NADP+ reductase activity
N8Z00_RS24810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N8Z00_RS24820	COG3842	ATPase activity
N8Z00_RS24845	COG0501	Belongs to the peptidase M48B family
N8Z00_RS24850	COG1760	l-serine dehydratase
N8Z00_RS24855	COG1283	sodium-dependent phosphate transmembrane transporter activity
N8Z00_RS24865	COG0428	transporter
N8Z00_RS24875	COG1611	Belongs to the LOG family
N8Z00_RS24880	COG1473	amidohydrolase
N8Z00_RS24885	COG0583	DNA-binding transcription factor activity
N8Z00_RS24895	COG1217	gtp-binding protein TYPA
N8Z00_RS24900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N8Z00_RS24905	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N8Z00_RS24910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N8Z00_RS24915	COG2251	uridine kinase activity
N8Z00_RS24915	COG0195	Participates in both transcription termination and antitermination
N8Z00_RS24920	COG0779	Required for maturation of 30S ribosomal subunits
N8Z00_RS24925	COG1187	pseudouridine synthase activity
N8Z00_RS24930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N8Z00_RS24940	COG0583	DNA-binding transcription factor activity
N8Z00_RS24945	COG0523	cobalamin synthesis protein
N8Z00_RS24965	COG0642	Histidine kinase
N8Z00_RS24970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N8Z00_RS24975	COG0625	glutathione transferase activity
N8Z00_RS24980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N8Z00_RS24985	COG0544	peptidyl-prolyl cis-trans isomerase activity
N8Z00_RS24990	COG2003	Belongs to the UPF0758 family
N8Z00_RS24995	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N8Z00_RS25005	COG3483	tryptophan 2,3-dioxygenase activity
N8Z00_RS25010	COG0254	rRNA binding
N8Z00_RS25020	COG0534	Mate efflux family protein
N8Z00_RS25030	COG2050	protein possibly involved in aromatic compounds catabolism
N8Z00_RS25035	COG1024	Enoyl-CoA hydratase
N8Z00_RS25040	COG1012	belongs to the aldehyde dehydrogenase family
N8Z00_RS25045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N8Z00_RS25050	COG2151	metal-sulfur cluster biosynthetic enzyme
N8Z00_RS25055	COG3396	Phenylacetate-CoA oxygenase
N8Z00_RS25060	COG3460	Phenylacetate-CoA oxygenase
N8Z00_RS25065	COG3396	Phenylacetate-CoA oxygenase
N8Z00_RS25070	COG3327	negative regulation of DNA-templated transcription, initiation
N8Z00_RS25075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N8Z00_RS25080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N8Z00_RS25085	COG0501	Belongs to the peptidase M48B family
N8Z00_RS25090	COG1162	GTPase activity
N8Z00_RS25100	COG0335	large ribosomal subunit rRNA binding
N8Z00_RS25120	COG2895	sulfate adenylyltransferase (ATP) activity
N8Z00_RS25130	COG0175	sulfate reduction
N8Z00_RS25140	COG4208	sulfate ABC transporter
N8Z00_RS25145	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N8Z00_RS25150	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
N8Z00_RS25155	COG0450	alkyl hydroperoxide reductase
N8Z00_RS25160	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS25165	COG2985	domain, Protein
N8Z00_RS25190	COG0123	including yeast histone deacetylase and acetoin utilization protein
N8Z00_RS25195	COG2951	lytic endotransglycosylase activity
N8Z00_RS25210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8Z00_RS25215	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N8Z00_RS25220	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
N8Z00_RS25240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N8Z00_RS25245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N8Z00_RS25250	COG0287	Prephenate dehydrogenase
N8Z00_RS25255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N8Z00_RS25265	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N8Z00_RS25280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N8Z00_RS25300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N8Z00_RS25310	COG1215	transferase activity, transferring glycosyl groups
N8Z00_RS25330	COG2951	lytic endotransglycosylase activity
N8Z00_RS25335	COG2258	MOSC domain
N8Z00_RS25340	COG2833	Protein of unknown function (DUF455)
N8Z00_RS25355	COG1132	(ABC) transporter
N8Z00_RS25360	COG0189	ligase activity
N8Z00_RS25360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N8Z00_RS25375	COG3237	CsbD-like
N8Z00_RS25400	COG0672	)-iron permease
N8Z00_RS25415	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
N8Z00_RS25420	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS25425	COG3243	poly(R)-hydroxyalkanoic acid synthase
N8Z00_RS25430	COG1496	oxidoreductase activity
N8Z00_RS25435	COG0564	pseudouridine synthase activity
N8Z00_RS25445	COG1199	ATP-dependent helicase activity
N8Z00_RS25450	COG2183	response to ionizing radiation
N8Z00_RS25485	COG4774	siderophore transport
N8Z00_RS25490	COG3712	iron ion homeostasis
N8Z00_RS25495	COG1595	DNA-templated transcription, initiation
N8Z00_RS25500	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N8Z00_RS25505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N8Z00_RS25510	COG0508	dehydrogenase complex catalyzes the overall conversion of
N8Z00_RS25515	COG0567	Dehydrogenase, E1 component
N8Z00_RS25520	COG1522	sequence-specific DNA binding
N8Z00_RS25525	COG2515	1-aminocyclopropane-1-carboxylate deaminase
N8Z00_RS25550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N8Z00_RS25555	COG2233	PERMEase
N8Z00_RS25560	COG1297	OPT oligopeptide transporter protein
N8Z00_RS25570	COG0281	malic enzyme
N8Z00_RS25570	COG0280	phosphate acetyltransferase
N8Z00_RS25585	COG0372	Belongs to the citrate synthase family
N8Z00_RS25590	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N8Z00_RS25595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N8Z00_RS25600	COG1053	succinate dehydrogenase
N8Z00_RS25605	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N8Z00_RS25610	COG2009	succinate dehydrogenase
N8Z00_RS25615	COG2188	Transcriptional regulator
N8Z00_RS25620	COG0039	L-malate dehydrogenase activity
N8Z00_RS25635	COG2079	MmgE PrpD family protein
N8Z00_RS25640	COG1981	membrane
N8Z00_RS25675	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N8Z00_RS25690	COG0148	phosphopyruvate hydratase activity
N8Z00_RS25700	COG0504	CTP synthase activity
N8Z00_RS25730	COG0601	transmembrane transport
N8Z00_RS25735	COG0747	negative chemotaxis
N8Z00_RS25740	COG4172	Belongs to the ABC transporter superfamily
N8Z00_RS25745	COG1446	asparaginase
N8Z00_RS25755	COG2153	protein acetylation
N8Z00_RS25780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N8Z00_RS25795	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
N8Z00_RS25800	COG0697	spore germination
N8Z00_RS25805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N8Z00_RS25815	COG3193	protein, possibly involved in utilization of glycolate and propanediol
N8Z00_RS25825	COG0791	NLP P60 protein
N8Z00_RS25835	COG0583	DNA-binding transcription factor activity
N8Z00_RS25860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N8Z00_RS25880	COG0667	Aldo Keto reductase
N8Z00_RS25890	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS25900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N8Z00_RS25910	COG1381	Involved in DNA repair and RecF pathway recombination
N8Z00_RS25915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N8Z00_RS25920	COG0571	ribonuclease III activity
N8Z00_RS25925	COG0681	Belongs to the peptidase S26 family
N8Z00_RS25935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N8Z00_RS25955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N8Z00_RS25960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N8Z00_RS25970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N8Z00_RS25975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N8Z00_RS25980	COG0416	fatty acid biosynthetic process
N8Z00_RS25985	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N8Z00_RS25990	COG1399	metal-binding, possibly nucleic acid-binding protein
N8Z00_RS25995	COG0424	maF-like protein
N8Z00_RS26005	COG3023	N-Acetylmuramoyl-L-alanine amidase
N8Z00_RS26010	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
N8Z00_RS26015	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N8Z00_RS26020	COG0546	phosphoglycolate phosphatase activity
N8Z00_RS26030	COG1530	ribonuclease E activity
N8Z00_RS26035	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
N8Z00_RS26040	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N8Z00_RS26045	COG0159	tryptophan synthase activity
N8Z00_RS26055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N8Z00_RS26065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N8Z00_RS26070	COG3228	Belongs to the MtfA family
N8Z00_RS26080	COG0251	oxidation-reduction process
N8Z00_RS26090	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
N8Z00_RS26105	COG2878	Part of a membrane complex involved in electron transport
N8Z00_RS26110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N8Z00_RS26145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N8Z00_RS26170	COG1268	BioY protein
N8Z00_RS26175	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N8Z00_RS26180	COG1122	ATPase activity
N8Z00_RS26185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N8Z00_RS26190	COG2917	probably involved in intracellular septation
N8Z00_RS26200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N8Z00_RS26205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N8Z00_RS26215	COG1196	nuclear chromosome segregation
N8Z00_RS26220	COG0477	Major facilitator Superfamily
N8Z00_RS26225	COG1573	uracil-dna glycosylase
N8Z00_RS26230	COG1214	PFAM Peptidase M22, glycoprotease
N8Z00_RS26245	COG0450	alkyl hydroperoxide reductase
N8Z00_RS26250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8Z00_RS26260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N8Z00_RS26265	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N8Z00_RS26270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N8Z00_RS26275	COG0560	Phosphoserine phosphatase
N8Z00_RS26280	COG4774	siderophore transport
N8Z00_RS26290	COG1007	ATP synthesis coupled electron transport
N8Z00_RS26305	COG0713	ATP synthesis coupled electron transport
N8Z00_RS26315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N8Z00_RS26320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N8Z00_RS26325	COG1034	ATP synthesis coupled electron transport
N8Z00_RS26335	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
N8Z00_RS26340	COG0649	NAD binding
N8Z00_RS26345	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N8Z00_RS26350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N8Z00_RS26355	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N8Z00_RS26360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N8Z00_RS26385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N8Z00_RS26405	COG0583	DNA-binding transcription factor activity
N8Z00_RS26420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N8Z00_RS26425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N8Z00_RS26430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N8Z00_RS26445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N8Z00_RS26460	COG4166	transmembrane transport
N8Z00_RS26465	COG4166	transmembrane transport
N8Z00_RS26475	COG4172	Belongs to the ABC transporter superfamily
N8Z00_RS26495	COG2354	Protein conserved in bacteria
N8Z00_RS26505	COG1278	Cold shock
N8Z00_RS26530	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS26535	COG2851	Citrate transporter
N8Z00_RS26565	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS26570	COG3119	arylsulfatase activity
N8Z00_RS26605	COG2199	diguanylate cyclase activity
N8Z00_RS26605	COG2203	Gaf domain
N8Z00_RS26635	COG2365	Tyrosine phosphatase family
N8Z00_RS26725	COG0582	viral genome integration into host DNA
N8Z00_RS26735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N8Z00_RS26740	COG0149	triose-phosphate isomerase activity
N8Z00_RS26745	COG3321	synthase
N8Z00_RS26745	COG0604	alcohol dehydrogenase
N8Z00_RS26745	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS26765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS26800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N8Z00_RS26810	COG1185	polyribonucleotide nucleotidyltransferase activity
N8Z00_RS26815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N8Z00_RS26825	COG1183	phosphatidylcholine synthase activity
N8Z00_RS26830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N8Z00_RS26835	COG0440	acetolactate synthase activity
N8Z00_RS26840	COG0028	Belongs to the TPP enzyme family
N8Z00_RS26845	COG1289	transmembrane transporter activity
N8Z00_RS26850	COG3022	response to hydroperoxide
N8Z00_RS26855	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS26880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N8Z00_RS26885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N8Z00_RS26890	COG0477	Major facilitator Superfamily
N8Z00_RS26940	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N8Z00_RS26945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N8Z00_RS26950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N8Z00_RS26960	COG0747	negative chemotaxis
N8Z00_RS26965	COG0601	transmembrane transport
N8Z00_RS26985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N8Z00_RS26985	COG0517	IMP dehydrogenase activity
N8Z00_RS26990	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
N8Z00_RS27000	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N8Z00_RS27005	COG1674	ftsk spoiiie
N8Z00_RS27010	COG0492	ferredoxin-NADP+ reductase activity
N8Z00_RS27015	COG1193	negative regulation of DNA recombination
N8Z00_RS27035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N8Z00_RS27050	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N8Z00_RS27055	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N8Z00_RS27060	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
N8Z00_RS27065	COG2205	protein histidine kinase activity
N8Z00_RS27070	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS27080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8Z00_RS27085	COG0840	transmembrane signaling receptor activity
N8Z00_RS27115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N8Z00_RS27140	COG0612	Peptidase, M16
N8Z00_RS27150	COG0484	heat shock protein binding
N8Z00_RS27155	COG0443	Heat shock 70 kDa protein
N8Z00_RS27165	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N8Z00_RS27175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N8Z00_RS27180	COG1420	regulation of RNA biosynthetic process
N8Z00_RS27190	COG0497	DNA recombination
N8Z00_RS27195	COG0735	belongs to the Fur family
N8Z00_RS27200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N8Z00_RS27220	COG3397	chitin binding
N8Z00_RS27225	COG3397	chitin binding
N8Z00_RS27235	COG2205	protein histidine kinase activity
N8Z00_RS27240	COG0745	RESPONSE REGULATOR receiver
N8Z00_RS27255	COG2165	general secretion pathway protein
N8Z00_RS27260	COG1450	Type ii and iii secretion system protein
N8Z00_RS27285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N8Z00_RS27290	COG1459	type II secretion system
N8Z00_RS27305	COG3038	cytochrome b561
N8Z00_RS27345	COG1063	alcohol dehydrogenase
N8Z00_RS27370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
N8Z00_RS27375	COG0247	lactate metabolic process
N8Z00_RS27375	COG2181	nitrate reductase activity
N8Z00_RS27380	COG1902	pentaerythritol trinitrate reductase activity
N8Z00_RS27380	COG0446	pyridine nucleotide-disulphide oxidoreductase
N8Z00_RS27585	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
N8Z00_RS27730	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS27745	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS27815	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N8Z00_RS27820	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N8Z00_RS27825	COG0167	dihydroorotate dehydrogenase activity
N8Z00_RS27840	COG1414	Transcriptional regulator
N8Z00_RS27845	COG1546	Belongs to the CinA family
N8Z00_RS27845	COG1058	Belongs to the CinA family
N8Z00_RS27860	COG0513	Belongs to the DEAD box helicase family
N8Z00_RS27885	COG0429	hydrolase of the alpha beta-hydrolase fold
N8Z00_RS27890	COG4783	chaperone-mediated protein folding
N8Z00_RS27910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N8Z00_RS27925	COG0006	proline dipeptidase activity
N8Z00_RS27935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8Z00_RS27955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N8Z00_RS27960	COG0632	four-way junction helicase activity
N8Z00_RS27965	COG1090	epimerase
N8Z00_RS27975	COG2255	four-way junction helicase activity
N8Z00_RS27980	COG4191	Histidine kinase
N8Z00_RS27995	COG0514	ATP-dependent DNA helicase (RecQ)
N8Z00_RS28005	COG1271	oxidase subunit
N8Z00_RS28010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N8Z00_RS28015	COG0850	regulation of cytokinetic process
N8Z00_RS28020	COG2894	cell division
N8Z00_RS28025	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
N8Z00_RS28040	COG0488	(ABC) transporter
N8Z00_RS28055	COG4608	Belongs to the ABC transporter superfamily
N8Z00_RS28060	COG0444	Belongs to the ABC transporter superfamily
N8Z00_RS28065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N8Z00_RS28070	COG0601	transmembrane transport
N8Z00_RS28075	COG0747	negative chemotaxis
N8Z00_RS28100	COG4638	Rieske (2fe-2S)
N8Z00_RS28125	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N8Z00_RS28130	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS28155	COG0463	Glycosyl transferase, family 2
N8Z00_RS28155	COG1216	Glycosyl transferase, family 2
N8Z00_RS28175	COG0800	Aldolase
N8Z00_RS28185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N8Z00_RS28220	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N8Z00_RS28225	COG1538	Outer membrane efflux protein
N8Z00_RS28230	COG0577	efflux transmembrane transporter activity
N8Z00_RS28230	COG1136	(ABC) transporter
N8Z00_RS28235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N8Z00_RS28250	COG0259	pyridoxamine-phosphate oxidase activity
N8Z00_RS28260	COG0579	oxidoreductase
N8Z00_RS28270	COG0583	DNA-binding transcription factor activity
N8Z00_RS28275	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS28285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS28290	COG0531	amino acid
N8Z00_RS28305	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS28315	COG0114	fumarate hydratase activity
N8Z00_RS28320	COG0802	atpase or kinase
N8Z00_RS28325	COG0860	N-Acetylmuramoyl-L-alanine amidase
N8Z00_RS28330	COG0586	Pfam SNARE associated Golgi protein
N8Z00_RS28335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N8Z00_RS28340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N8Z00_RS28345	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N8Z00_RS28360	COG0617	tRNA 3'-terminal CCA addition
N8Z00_RS28365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N8Z00_RS28370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N8Z00_RS28375	COG2301	Belongs to the HpcH HpaI aldolase family
N8Z00_RS28380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS28385	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
N8Z00_RS28390	COG0583	DNA-binding transcription factor activity
N8Z00_RS28395	COG1024	Enoyl-CoA hydratase
N8Z00_RS28405	COG1960	acyl-CoA dehydrogenase activity
N8Z00_RS28420	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS28445	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS28450	COG2030	dehydratase
N8Z00_RS28455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N8Z00_RS28465	COG1024	Enoyl-CoA hydratase
N8Z00_RS28470	COG0752	glycyl-tRNA synthetase alpha subunit
N8Z00_RS28475	COG0751	glycine-tRNA ligase activity
N8Z00_RS28480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N8Z00_RS28485	COG0204	Acyl-transferase
N8Z00_RS28500	COG0242	peptide deformylase activity
N8Z00_RS28510	COG0700	Nucleoside recognition
N8Z00_RS28515	COG0469	pyruvate kinase activity
N8Z00_RS28520	COG1929	Belongs to the glycerate kinase type-1 family
N8Z00_RS28525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N8Z00_RS28530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N8Z00_RS28545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N8Z00_RS28570	COG2154	pterin-4-alpha-carbinolamine dehydratase
N8Z00_RS28800	COG0330	HflC and HflK could
N8Z00_RS28825	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS28830	COG1309	transcriptional regulator
N8Z00_RS28840	COG2982	Protein involved in outer membrane biogenesis
N8Z00_RS28845	COG1368	sulfuric ester hydrolase activity
N8Z00_RS28850	COG2818	Glycosylase
N8Z00_RS28865	COG0735	belongs to the Fur family
N8Z00_RS28880	COG2911	Protein conserved in bacteria
N8Z00_RS28880	COG3210	domain, Protein
N8Z00_RS28895	COG1414	Transcriptional regulator
N8Z00_RS28900	COG1024	Enoyl-CoA hydratase
N8Z00_RS28905	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS28915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N8Z00_RS28950	COG2011	ABC-type metal ion transport system permease component
N8Z00_RS28955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N8Z00_RS28960	COG1501	Belongs to the glycosyl hydrolase 31 family
N8Z00_RS28965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8Z00_RS28965	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N8Z00_RS28970	COG0483	inositol monophosphate 1-phosphatase activity
N8Z00_RS28975	COG0318	PFAM AMP-dependent synthetase and ligase
N8Z00_RS28980	COG1473	amidohydrolase
N8Z00_RS28990	COG2855	membrane
N8Z00_RS29000	COG2239	Acts as a magnesium transporter
N8Z00_RS29015	COG1522	sequence-specific DNA binding
N8Z00_RS29020	COG1028	Short-chain dehydrogenase reductase Sdr
N8Z00_RS29025	COG0028	Belongs to the TPP enzyme family
N8Z00_RS29030	COG3181	Tripartite tricarboxylate transporter family receptor
N8Z00_RS29055	COG0739	heme binding
N8Z00_RS29065	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N8Z00_RS29070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N8Z00_RS29080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N8Z00_RS29085	COG1181	Belongs to the D-alanine--D-alanine ligase family
N8Z00_RS29090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N8Z00_RS29095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N8Z00_RS29105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N8Z00_RS29110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N8Z00_RS29115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N8Z00_RS29125	COG3116	cell division
N8Z00_RS29130	COG0275	rRNA processing
N8Z00_RS29135	COG2001	Belongs to the MraZ family
N8Z00_RS29145	COG0488	(ABC) transporter
N8Z00_RS29150	COG0418	dihydroorotase activity
N8Z00_RS29155	COG1473	amidohydrolase