locus-tag	class	description
LH59_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LH59_RS00010	COG0592	DNA-directed DNA polymerase activity
LH59_RS00020	COG0583	DNA-binding transcription factor activity
LH59_RS00045	COG1574	metal-dependent hydrolase with the TIM-barrel fold
LH59_RS00055	COG0583	DNA-binding transcription factor activity
LH59_RS00060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS00065	COG0765	amino acid transport
LH59_RS00070	COG0765	amino acid transport
LH59_RS00075	COG1126	abc transporter atp-binding protein
LH59_RS00115	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH59_RS00120	COG1177	transmembrane transport
LH59_RS00175	COG1609	Transcriptional regulator
LH59_RS00185	COG3842	ATPase activity
LH59_RS00190	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH59_RS00195	COG1177	transmembrane transport
LH59_RS00220	COG0251	oxidation-reduction process
LH59_RS00225	COG0402	S-adenosylhomocysteine deaminase activity
LH59_RS00235	COG4603	Belongs to the binding-protein-dependent transport system permease family
LH59_RS00240	COG3845	ABC transporter
LH59_RS00245	COG1744	ABC transporter substrate-binding protein PnrA-like
LH59_RS00255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH59_RS00270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH59_RS00285	COG2814	Major facilitator Superfamily
LH59_RS00300	COG3781	membrane
LH59_RS00305	COG1522	sequence-specific DNA binding
LH59_RS00310	COG0028	Belongs to the TPP enzyme family
LH59_RS00315	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS00320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS00345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH59_RS00350	COG2922	Belongs to the Smg family
LH59_RS00360	COG2358	TRAP transporter, solute receptor (TAXI family
LH59_RS00380	COG0765	amino acid transport
LH59_RS00385	COG0765	amino acid transport
LH59_RS00390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS00395	COG3422	double-strand break repair
LH59_RS00400	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS00405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LH59_RS00415	COG4977	sequence-specific DNA binding
LH59_RS00420	COG2814	Major facilitator Superfamily
LH59_RS00430	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
LH59_RS00440	COG3339	Conserved Protein
LH59_RS00470	COG2186	Transcriptional regulator
LH59_RS00475	COG2814	Major facilitator Superfamily
LH59_RS00490	COG1595	DNA-templated transcription, initiation
LH59_RS00495	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS00510	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS00520	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS00560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LH59_RS00565	COG0183	Belongs to the thiolase family
LH59_RS00570	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LH59_RS00575	COG1960	acyl-CoA dehydrogenase activity
LH59_RS00580	COG1473	amidohydrolase
LH59_RS00590	COG1742	UPF0060 membrane protein
LH59_RS00605	COG1280	lysine exporter protein (LysE YggA)
LH59_RS00630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH59_RS00640	COG0018	arginyl-trna synthetase
LH59_RS00655	COG0395	ABC-type sugar transport system, permease component
LH59_RS00660	COG1175	transmembrane transport
LH59_RS00665	COG1653	transport
LH59_RS00670	COG3842	ATPase activity
LH59_RS00675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH59_RS00680	COG1609	Transcriptional regulator
LH59_RS00690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH59_RS00705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LH59_RS00725	COG0583	DNA-binding transcription factor activity
LH59_RS00750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LH59_RS00755	COG1280	lysine exporter protein (LysE YggA)
LH59_RS00760	COG0513	Belongs to the DEAD box helicase family
LH59_RS00765	COG5339	Protein conserved in bacteria
LH59_RS00770	COG5339	Protein conserved in bacteria
LH59_RS00775	COG1228	amidohydrolase
LH59_RS00785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS00790	COG0601	transmembrane transport
LH59_RS00795	COG0747	negative chemotaxis
LH59_RS00800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH59_RS00810	COG3708	Transcriptional regulator
LH59_RS00810	COG2207	Transcriptional regulator
LH59_RS00830	COG0583	DNA-binding transcription factor activity
LH59_RS00860	COG2969	positive regulation of protein catabolic process
LH59_RS00865	COG0625	glutathione transferase activity
LH59_RS00870	COG2857	Cytochrome c1
LH59_RS00875	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LH59_RS00880	COG0723	plastoquinol--plastocyanin reductase activity
LH59_RS00885	COG1970	mechanosensitive ion channel activity
LH59_RS00890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LH59_RS00895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH59_RS00910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LH59_RS00915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LH59_RS00920	COG0537	adenosine 5'-monophosphoramidase activity
LH59_RS00925	COG0140	phosphoribosyl-ATP diphosphatase activity
LH59_RS00935	COG0107	imidazoleglycerol-phosphate synthase activity
LH59_RS00940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LH59_RS00945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LH59_RS00950	COG0131	Imidazoleglycerol-phosphate dehydratase
LH59_RS00955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH59_RS00960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LH59_RS00965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LH59_RS00970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LH59_RS00980	COG0842	Transport permease protein
LH59_RS00985	COG1131	(ABC) transporter
LH59_RS00995	COG2853	Lipoprotein
LH59_RS01000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LH59_RS01005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LH59_RS01010	COG1127	ABC transporter
LH59_RS01015	COG2070	2-Nitropropane dioxygenase
LH59_RS01025	COG0477	Major facilitator Superfamily
LH59_RS01040	COG0583	DNA-binding transcription factor activity
LH59_RS01045	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LH59_RS01050	COG0511	ligase activity, forming carbon-carbon bonds
LH59_RS01065	COG1984	allophanate hydrolase subunit 2
LH59_RS01080	COG0067	glutamate synthase
LH59_RS01080	COG0069	glutamate synthase activity
LH59_RS01080	COG0070	glutamate synthase
LH59_RS01105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH59_RS01125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH59_RS01160	COG1612	heme a metabolic process
LH59_RS01170	COG1999	signal sequence binding
LH59_RS01190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LH59_RS01195	COG2814	Major facilitator Superfamily
LH59_RS01205	COG0438	transferase activity, transferring glycosyl groups
LH59_RS01225	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LH59_RS01230	COG1959	2 iron, 2 sulfur cluster binding
LH59_RS01235	COG2814	Major facilitator Superfamily
LH59_RS01245	COG4774	siderophore transport
LH59_RS01250	COG4592	Periplasmic binding protein
LH59_RS01255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_RS01260	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_RS01265	COG1120	ATPase activity
LH59_RS01270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH59_RS01285	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LH59_RS01310	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LH59_RS01315	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LH59_RS01320	COG2814	Major facilitator Superfamily
LH59_RS01325	COG0583	DNA-binding transcription factor activity
LH59_RS01335	COG2423	ornithine cyclodeaminase activity
LH59_RS01340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LH59_RS01345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LH59_RS01355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH59_RS01365	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LH59_RS01370	COG0463	Glycosyl transferase, family 2
LH59_RS01420	COG0737	Belongs to the 5'-nucleotidase family
LH59_RS01435	COG2188	Transcriptional regulator
LH59_RS01445	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LH59_RS01450	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LH59_RS01465	COG0840	transmembrane signaling receptor activity
LH59_RS01470	COG2814	Major facilitator Superfamily
LH59_RS01485	COG3188	usher protein
LH59_RS01545	COG1802	Transcriptional regulator
LH59_RS01555	COG3069	C4-dicarboxylate transmembrane transporter activity
LH59_RS01560	COG1012	belongs to the aldehyde dehydrogenase family
LH59_RS01585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS01595	COG0747	negative chemotaxis
LH59_RS01620	COG1464	Belongs to the NlpA lipoprotein family
LH59_RS01625	COG0431	NADPH-dependent FMN reductase
LH59_RS01630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_RS01635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH59_RS01640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS01655	COG2011	ABC-type metal ion transport system permease component
LH59_RS01660	COG1464	Belongs to the NlpA lipoprotein family
LH59_RS01665	COG1116	anion transmembrane transporter activity
LH59_RS01670	COG3585	molybdate ion transport
LH59_RS01675	COG3064	Membrane
LH59_RS01700	COG1607	acyl-coa hydrolase
LH59_RS01710	COG3383	formate dehydrogenase (NAD+) activity
LH59_RS01710	COG0243	molybdopterin cofactor binding
LH59_RS01715	COG3383	formate dehydrogenase (NAD+) activity
LH59_RS01715	COG0243	molybdopterin cofactor binding
LH59_RS01720	COG0437	4 iron, 4 sulfur cluster binding
LH59_RS01725	COG2864	formate dehydrogenase
LH59_RS01740	COG3276	selenocysteine insertion sequence binding
LH59_RS01750	COG1216	Glycosyl transferase, family 2
LH59_RS01755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_RS01760	COG1305	Transglutaminase-like
LH59_RS01765	COG0709	Synthesizes selenophosphate from selenide and ATP
LH59_RS01795	COG1012	belongs to the aldehyde dehydrogenase family
LH59_RS01800	COG3284	Transcriptional regulator
LH59_RS01805	COG0134	indole-3-glycerol-phosphate synthase activity
LH59_RS01810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LH59_RS01815	COG0512	Glutamine amidotransferase of anthranilate synthase
LH59_RS01825	COG0546	phosphoglycolate phosphatase activity
LH59_RS01830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LH59_RS01835	COG2967	ApaG domain
LH59_RS01845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH59_RS01850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH59_RS01860	COG0037	tRNA processing
LH59_RS01875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH59_RS01890	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_RS01895	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_RS01910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH59_RS01935	COG3473	Maleate cis-trans isomerase
LH59_RS01940	COG0583	DNA-binding transcription factor activity
LH59_RS01955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LH59_RS01965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH59_RS01970	COG1024	Enoyl-CoA hydratase
LH59_RS01985	COG0356	it plays a direct role in the translocation of protons across the membrane
LH59_RS02000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LH59_RS02005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LH59_RS02010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LH59_RS02020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LH59_RS02030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LH59_RS02035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LH59_RS02040	COG0210	DNA helicase
LH59_RS02055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LH59_RS02060	COG4221	oxidoreductase activity
LH59_RS02070	COG2171	N-acyltransferase activity
LH59_RS02080	COG2195	Cleaves the N-terminal amino acid of tripeptides
LH59_RS02090	COG4608	Belongs to the ABC transporter superfamily
LH59_RS02095	COG0444	Belongs to the ABC transporter superfamily
LH59_RS02105	COG0601	transmembrane transport
LH59_RS02110	COG0747	negative chemotaxis
LH59_RS02115	COG2988	succinylglutamate desuccinylase activity
LH59_RS02130	COG0747	negative chemotaxis
LH59_RS02140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LH59_RS02145	COG1024	Enoyl-CoA hydratase
LH59_RS02150	COG1024	Enoyl-CoA hydratase
LH59_RS02160	COG1309	transcriptional regulator
LH59_RS02175	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_RS02190	COG2814	Major facilitator Superfamily
LH59_RS02205	COG1764	response to oxidative stress
LH59_RS02210	COG0583	DNA-binding transcription factor activity
LH59_RS02220	COG1595	DNA-templated transcription, initiation
LH59_RS02225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH59_RS02245	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH59_RS02265	COG1129	ABC transporter
LH59_RS02280	COG1802	Transcriptional regulator
LH59_RS02290	COG0583	DNA-binding transcription factor activity
LH59_RS02300	COG2988	succinylglutamate desuccinylase activity
LH59_RS02310	COG2918	glutathione biosynthetic process
LH59_RS02340	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LH59_RS02345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH59_RS02355	COG2721	sulfolactate sulfo-lyase activity
LH59_RS02360	COG2721	sulfolactate sulfo-lyase activity
LH59_RS02365	COG2188	Transcriptional regulator
LH59_RS02370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH59_RS02375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH59_RS02375	COG2813	Specifically methylates the guanine in position
LH59_RS02380	COG2223	nitrite transmembrane transporter activity
LH59_RS02390	COG2860	membrane
LH59_RS02395	COG1802	Transcriptional regulator
LH59_RS02405	COG1984	allophanate hydrolase subunit 2
LH59_RS02410	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LH59_RS02420	COG0583	DNA-binding transcription factor activity
LH59_RS02430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH59_RS02445	COG2132	Multicopper oxidase
LH59_RS02470	COG0745	RESPONSE REGULATOR receiver
LH59_RS02475	COG2226	methyltransferase
LH59_RS02490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LH59_RS02500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LH59_RS02510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LH59_RS02515	COG0351	phosphomethylpyrimidine kinase
LH59_RS02520	COG2022	thiamine diphosphate biosynthetic process
LH59_RS02525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LH59_RS02530	COG4771	TonB-dependent receptor
LH59_RS02540	COG2186	Transcriptional regulator
LH59_RS02555	COG1063	alcohol dehydrogenase
LH59_RS02565	COG0765	amino acid transport
LH59_RS02570	COG1126	abc transporter atp-binding protein
LH59_RS02575	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_RS02580	COG0246	Mannitol dehydrogenase
LH59_RS02620	COG2177	Part of the ABC transporter FtsEX involved in
LH59_RS02625	COG2884	Cell division ATP-binding protein ftsE
LH59_RS02630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS02635	COG4597	amino acid ABC transporter
LH59_RS02640	COG0765	amino acid transport
LH59_RS02645	COG1126	abc transporter atp-binding protein
LH59_RS02670	COG1129	ABC transporter
LH59_RS02675	COG4177	L-phenylalanine transmembrane transporter activity
LH59_RS02690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH59_RS02695	COG2081	HI0933 family
LH59_RS02705	COG1605	Chorismate mutase
LH59_RS02705	COG0077	Prephenate dehydratase
LH59_RS02740	COG0477	Major facilitator Superfamily
LH59_RS02750	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LH59_RS02755	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LH59_RS02775	COG0237	dephospho-CoA kinase activity
LH59_RS02780	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LH59_RS02810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_RS02815	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LH59_RS02830	COG3833	ABC-type maltose transport systems, permease component
LH59_RS02835	COG1175	transmembrane transport
LH59_RS02840	COG3842	ATPase activity
LH59_RS02860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LH59_RS02895	COG0410	ABC transporter
LH59_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS02935	COG1024	Enoyl-CoA hydratase
LH59_RS02975	COG4638	Rieske (2fe-2S)
LH59_RS02980	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LH59_RS02985	COG1335	isochorismatase
LH59_RS02990	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS03000	COG0741	lytic transglycosylase activity
LH59_RS03005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LH59_RS03010	COG0352	thiamine-phosphate diphosphorylase activity
LH59_RS03025	COG1678	Uncharacterized ACR, COG1678
LH59_RS03030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LH59_RS03060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH59_RS03065	COG0436	Aminotransferase
LH59_RS03070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS03080	COG0765	amino acid transport
LH59_RS03085	COG1126	abc transporter atp-binding protein
LH59_RS03090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LH59_RS03100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LH59_RS03105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH59_RS03120	COG1175	transmembrane transport
LH59_RS03140	COG0557	exoribonuclease II activity
LH59_RS03145	COG3150	esterase
LH59_RS03150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH59_RS03155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_RS03160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LH59_RS03165	COG0511	ligase activity, forming carbon-carbon bonds
LH59_RS03170	COG0439	Biotin carboxylase
LH59_RS03175	COG2264	protein methyltransferase activity
LH59_RS03185	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LH59_RS03185	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LH59_RS03210	COG1696	Membrane protein involved in D-alanine export
LH59_RS03215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LH59_RS03250	COG1522	sequence-specific DNA binding
LH59_RS03255	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS03265	COG0583	DNA-binding transcription factor activity
LH59_RS03280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH59_RS03285	COG1042	CoA-binding domain protein
LH59_RS03285	COG0045	succinate-CoA ligase (ADP-forming) activity
LH59_RS03285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH59_RS03290	COG1335	isochorismatase
LH59_RS03295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS03300	COG1116	anion transmembrane transporter activity
LH59_RS03315	COG3028	Belongs to the UPF0307 family
LH59_RS03320	COG0312	modulator of DNA gyrase
LH59_RS03325	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LH59_RS03335	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_RS03340	COG4177	L-phenylalanine transmembrane transporter activity
LH59_RS03355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LH59_RS03360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LH59_RS03365	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LH59_RS03375	COG0316	Belongs to the HesB IscA family
LH59_RS03390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LH59_RS03405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LH59_RS03410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LH59_RS03420	COG1335	isochorismatase
LH59_RS03425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH59_RS03425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH59_RS03440	COG2766	serine protein kinase
LH59_RS03445	COG2718	Belongs to the UPF0229 family
LH59_RS03450	COG2719	SpoVR family
LH59_RS03460	COG0583	DNA-binding transcription factor activity
LH59_RS03465	COG1942	4-Oxalocrotonate Tautomerase
LH59_RS03475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH59_RS03485	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS03505	COG2770	Histidine kinase
LH59_RS03505	COG2208	phosphoserine phosphatase activity
LH59_RS03515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LH59_RS03520	COG2172	sigma factor antagonist activity
LH59_RS03525	COG1366	Belongs to the anti-sigma-factor antagonist family
LH59_RS03565	COG0741	lytic transglycosylase activity
LH59_RS03565	COG1388	LysM domain
LH59_RS03570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH59_RS03575	COG2226	methyltransferase
LH59_RS03580	COG0328	RNA-DNA hybrid ribonuclease activity
LH59_RS03590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH59_RS03595	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH59_RS03610	COG1671	Belongs to the UPF0178 family
LH59_RS03625	COG0786	glutamate:sodium symporter activity
LH59_RS03635	COG0463	Glycosyl transferase, family 2
LH59_RS03640	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LH59_RS03655	COG0583	DNA-binding transcription factor activity
LH59_RS03675	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_RS03695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_RS03705	COG0583	DNA-binding transcription factor activity
LH59_RS03715	COG1346	cytolysis
LH59_RS03725	COG0697	spore germination
LH59_RS03730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS03745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LH59_RS03755	COG1522	sequence-specific DNA binding
LH59_RS03770	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LH59_RS03775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_RS03790	COG0823	Involved in the tonB-independent uptake of proteins
LH59_RS03800	COG0848	biopolymer transport protein
LH59_RS03805	COG0811	peptide transport
LH59_RS03810	COG0824	Thioesterase
LH59_RS03815	COG0442	prolyl-tRNA aminoacylation
LH59_RS03845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH59_RS03860	COG2084	Dehydrogenase
LH59_RS03865	COG0405	Gamma-glutamyltransferase
LH59_RS03900	COG0129	dihydroxy-acid dehydratase activity
LH59_RS03905	COG4654	Cytochrome c, class I
LH59_RS03910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH59_RS03920	COG1522	sequence-specific DNA binding
LH59_RS03965	COG0583	DNA-binding transcription factor activity
LH59_RS03975	COG1473	amidohydrolase
LH59_RS03980	COG0418	dihydroorotase activity
LH59_RS03985	COG0488	(ABC) transporter
LH59_RS03990	COG2001	Belongs to the MraZ family
LH59_RS03995	COG0275	rRNA processing
LH59_RS04000	COG3116	cell division
LH59_RS04010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH59_RS04015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH59_RS04020	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LH59_RS04030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LH59_RS04035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH59_RS04040	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH59_RS04045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LH59_RS04055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LH59_RS04060	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LH59_RS04070	COG0739	heme binding
LH59_RS04075	COG0653	protein targeting
LH59_RS04090	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS04095	COG0028	Belongs to the TPP enzyme family
LH59_RS04105	COG0300	oxidoreductase activity
LH59_RS04110	COG1522	sequence-specific DNA binding
LH59_RS04125	COG2239	Acts as a magnesium transporter
LH59_RS04135	COG2855	membrane
LH59_RS04140	COG0583	DNA-binding transcription factor activity
LH59_RS04145	COG1473	amidohydrolase
LH59_RS04150	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS04155	COG0483	inositol monophosphate 1-phosphatase activity
LH59_RS04160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_RS04160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LH59_RS04165	COG1501	Belongs to the glycosyl hydrolase 31 family
LH59_RS04170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LH59_RS04175	COG2011	ABC-type metal ion transport system permease component
LH59_RS04190	COG1595	DNA-templated transcription, initiation
LH59_RS04195	COG3712	iron ion homeostasis
LH59_RS04215	COG0840	transmembrane signaling receptor activity
LH59_RS04220	COG0583	DNA-binding transcription factor activity
LH59_RS04230	COG0735	belongs to the Fur family
LH59_RS04250	COG2818	Glycosylase
LH59_RS04255	COG1368	sulfuric ester hydrolase activity
LH59_RS04260	COG2982	Protein involved in outer membrane biogenesis
LH59_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS04305	COG2154	pterin-4-alpha-carbinolamine dehydratase
LH59_RS04320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH59_RS04330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LH59_RS04335	COG3178	'Phosphotransferase
LH59_RS04345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_RS04350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LH59_RS04355	COG1929	Belongs to the glycerate kinase type-1 family
LH59_RS04360	COG0469	pyruvate kinase activity
LH59_RS04365	COG0700	Nucleoside recognition
LH59_RS04370	COG1960	acyl-CoA dehydrogenase activity
LH59_RS04375	COG0242	peptide deformylase activity
LH59_RS04395	COG0204	Acyl-transferase
LH59_RS04400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LH59_RS04405	COG0751	glycine-tRNA ligase activity
LH59_RS04410	COG0752	glycyl-tRNA synthetase alpha subunit
LH59_RS04415	COG1024	Enoyl-CoA hydratase
LH59_RS04435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_RS04440	COG2030	dehydratase
LH59_RS04445	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS04460	COG2070	2-Nitropropane dioxygenase
LH59_RS04470	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS04475	COG0183	Belongs to the thiolase family
LH59_RS04485	COG1960	acyl-CoA dehydrogenase activity
LH59_RS04495	COG1024	Enoyl-CoA hydratase
LH59_RS04505	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
LH59_RS04515	COG2301	Belongs to the HpcH HpaI aldolase family
LH59_RS04520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH59_RS04530	COG0617	tRNA 3'-terminal CCA addition
LH59_RS04545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LH59_RS04555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LH59_RS04560	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LH59_RS04565	COG0586	Pfam SNARE associated Golgi protein
LH59_RS04575	COG0860	N-Acetylmuramoyl-L-alanine amidase
LH59_RS04580	COG0114	fumarate hydratase activity
LH59_RS04590	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS04605	COG0531	amino acid
LH59_RS04610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_RS04620	COG1960	acyl-CoA dehydrogenase activity
LH59_RS04625	COG0583	DNA-binding transcription factor activity
LH59_RS04630	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH59_RS04650	COG2175	clavaminate synthase activity
LH59_RS04660	COG0583	DNA-binding transcription factor activity
LH59_RS04670	COG0579	oxidoreductase
LH59_RS04680	COG0259	pyridoxamine-phosphate oxidase activity
LH59_RS04695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_RS04700	COG0577	efflux transmembrane transporter activity
LH59_RS04700	COG1136	(ABC) transporter
LH59_RS04705	COG1538	Outer membrane efflux protein
LH59_RS04710	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LH59_RS04745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LH59_RS04755	COG0800	Aldolase
LH59_RS04770	COG1216	Glycosyl transferase, family 2
LH59_RS04770	COG0463	Glycosyl transferase, family 2
LH59_RS04795	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS04800	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LH59_RS04820	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LH59_RS04825	COG4638	Rieske (2fe-2S)
LH59_RS04850	COG0747	negative chemotaxis
LH59_RS04855	COG0601	transmembrane transport
LH59_RS04860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS04865	COG0444	Belongs to the ABC transporter superfamily
LH59_RS04870	COG4608	Belongs to the ABC transporter superfamily
LH59_RS04890	COG2746	aminoglycoside 3-N-acetyltransferase activity
LH59_RS04895	COG0488	(ABC) transporter
LH59_RS04915	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LH59_RS04920	COG2894	cell division
LH59_RS04925	COG0850	regulation of cytokinetic process
LH59_RS04930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH59_RS04940	COG1294	oxidase, subunit
LH59_RS04945	COG0514	ATP-dependent DNA helicase (RecQ)
LH59_RS04960	COG4191	Histidine kinase
LH59_RS04965	COG2255	four-way junction helicase activity
LH59_RS04975	COG1090	epimerase
LH59_RS04980	COG0632	four-way junction helicase activity
LH59_RS05005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH59_RS05015	COG0006	proline dipeptidase activity
LH59_RS05030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LH59_RS05035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_RS05050	COG4783	chaperone-mediated protein folding
LH59_RS05090	COG2814	Major facilitator Superfamily
LH59_RS05095	COG4771	TonB-dependent receptor
LH59_RS05105	COG0513	Belongs to the DEAD box helicase family
LH59_RS05120	COG1546	Belongs to the CinA family
LH59_RS05120	COG1058	Belongs to the CinA family
LH59_RS05125	COG1414	Transcriptional regulator
LH59_RS05140	COG0167	dihydroorotate dehydrogenase activity
LH59_RS05145	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LH59_RS05150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LH59_RS05230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH59_RS05235	COG0735	belongs to the Fur family
LH59_RS05240	COG0497	DNA recombination
LH59_RS05250	COG1420	regulation of RNA biosynthetic process
LH59_RS05255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LH59_RS05265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LH59_RS05275	COG0443	Heat shock 70 kDa protein
LH59_RS05280	COG0484	heat shock protein binding
LH59_RS05290	COG0612	Peptidase, M16
LH59_RS05315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LH59_RS05350	COG0840	transmembrane signaling receptor activity
LH59_RS05355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_RS05370	COG0745	RESPONSE REGULATOR receiver
LH59_RS05375	COG2205	protein histidine kinase activity
LH59_RS05380	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LH59_RS05385	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LH59_RS05390	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LH59_RS05405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH59_RS05415	COG1193	negative regulation of DNA recombination
LH59_RS05420	COG0492	ferredoxin-NADP+ reductase activity
LH59_RS05425	COG1674	ftsk spoiiie
LH59_RS05430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LH59_RS05435	COG0251	oxidation-reduction process
LH59_RS05440	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LH59_RS05445	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LH59_RS05445	COG0517	IMP dehydrogenase activity
LH59_RS05465	COG0601	transmembrane transport
LH59_RS05480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH59_RS05485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LH59_RS05490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LH59_RS05520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_RS05530	COG4774	siderophore transport
LH59_RS05535	COG4607	ABC-type enterochelin transport system periplasmic component
LH59_RS05540	COG4604	ABC transporter, ATP-binding protein
LH59_RS05545	COG4605	iron ion homeostasis
LH59_RS05550	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_RS05555	COG1132	(ABC) transporter
LH59_RS05560	COG1132	(ABC) transporter
LH59_RS05560	COG2375	cellular response to nickel ion
LH59_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS05585	COG3022	response to hydroperoxide
LH59_RS05590	COG1289	transmembrane transporter activity
LH59_RS05595	COG0028	Belongs to the TPP enzyme family
LH59_RS05600	COG0440	acetolactate synthase activity
LH59_RS05605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LH59_RS05610	COG1183	phosphatidylcholine synthase activity
LH59_RS05620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LH59_RS05625	COG1185	polyribonucleotide nucleotidyltransferase activity
LH59_RS05635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LH59_RS05655	COG2207	Transcriptional regulator
LH59_RS05680	COG0149	triose-phosphate isomerase activity
LH59_RS05685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH59_RS05700	COG2885	chlorophyll binding
LH59_RS05700	COG3047	cAMP biosynthetic process
LH59_RS05725	COG0840	transmembrane signaling receptor activity
LH59_RS05745	COG1910	domain protein
LH59_RS05780	COG1116	anion transmembrane transporter activity
LH59_RS05795	COG1595	DNA-templated transcription, initiation
LH59_RS05800	COG3712	iron ion homeostasis
LH59_RS05820	COG0642	Histidine kinase
LH59_RS05830	COG2851	Citrate transporter
LH59_RS05835	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS05855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LH59_RS05860	COG4191	Histidine kinase
LH59_RS05860	COG0784	Response regulator, receiver
LH59_RS05875	COG3604	Transcriptional regulator
LH59_RS05880	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
LH59_RS05885	COG3813	Protein conserved in bacteria
LH59_RS05890	COG2354	Protein conserved in bacteria
LH59_RS05895	COG4772	TonB-dependent receptor
LH59_RS05900	COG1522	sequence-specific DNA binding
LH59_RS05920	COG4172	Belongs to the ABC transporter superfamily
LH59_RS05930	COG0747	negative chemotaxis
LH59_RS05950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH59_RS05965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LH59_RS05970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_RS05975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH59_RS05995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH59_RS06005	COG1309	transcriptional regulator
LH59_RS06010	COG0583	DNA-binding transcription factor activity
LH59_RS06030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH59_RS06055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_RS06060	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH59_RS06065	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH59_RS06070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH59_RS06075	COG0649	NAD binding
LH59_RS06080	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LH59_RS06090	COG1034	ATP synthesis coupled electron transport
LH59_RS06095	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LH59_RS06100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH59_RS06110	COG0713	ATP synthesis coupled electron transport
LH59_RS06125	COG1007	ATP synthesis coupled electron transport
LH59_RS06135	COG4774	siderophore transport
LH59_RS06140	COG0560	Phosphoserine phosphatase
LH59_RS06145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LH59_RS06150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LH59_RS06155	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LH59_RS06165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH59_RS06170	COG0450	alkyl hydroperoxide reductase
LH59_RS06185	COG1214	PFAM Peptidase M22, glycoprotease
LH59_RS06190	COG1573	uracil-dna glycosylase
LH59_RS06195	COG0477	Major facilitator Superfamily
LH59_RS06200	COG1196	nuclear chromosome segregation
LH59_RS06210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LH59_RS06215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_RS06225	COG2917	probably involved in intracellular septation
LH59_RS06230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH59_RS06235	COG1122	ATPase activity
LH59_RS06240	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LH59_RS06245	COG1268	BioY protein
LH59_RS06280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LH59_RS06315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LH59_RS06320	COG2878	Part of a membrane complex involved in electron transport
LH59_RS06335	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LH59_RS06340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LH59_RS06345	COG0251	oxidation-reduction process
LH59_RS06355	COG3228	Belongs to the MtfA family
LH59_RS06360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LH59_RS06370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH59_RS06380	COG0159	tryptophan synthase activity
LH59_RS06385	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LH59_RS06390	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LH59_RS06395	COG1530	ribonuclease E activity
LH59_RS06400	COG0564	pseudouridine synthase activity
LH59_RS06405	COG0546	phosphoglycolate phosphatase activity
LH59_RS06410	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LH59_RS06415	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LH59_RS06430	COG0424	maF-like protein
LH59_RS06435	COG1399	metal-binding, possibly nucleic acid-binding protein
LH59_RS06440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LH59_RS06450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH59_RS06455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LH59_RS06465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH59_RS06470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH59_RS06495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH59_RS06500	COG0481	GTPase activity
LH59_RS06505	COG0681	Belongs to the peptidase S26 family
LH59_RS06510	COG0571	ribonuclease III activity
LH59_RS06515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LH59_RS06520	COG1381	Involved in DNA repair and RecF pathway recombination
LH59_RS06570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH59_RS06595	COG0583	DNA-binding transcription factor activity
LH59_RS06605	COG0791	NLP P60 protein
LH59_RS06615	COG3193	protein, possibly involved in utilization of glycolate and propanediol
LH59_RS06625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH59_RS06630	COG0697	spore germination
LH59_RS06635	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LH59_RS06640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH59_RS06660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_RS06685	COG2153	protein acetylation
LH59_RS06695	COG1446	asparaginase
LH59_RS06700	COG4172	Belongs to the ABC transporter superfamily
LH59_RS06705	COG0747	negative chemotaxis
LH59_RS06740	COG0504	CTP synthase activity
LH59_RS06750	COG0148	phosphopyruvate hydratase activity
LH59_RS06765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LH59_RS06775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH59_RS06810	COG1981	membrane
LH59_RS06830	COG0039	L-malate dehydrogenase activity
LH59_RS06835	COG2188	Transcriptional regulator
LH59_RS06840	COG2009	succinate dehydrogenase
LH59_RS06845	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LH59_RS06850	COG1053	succinate dehydrogenase
LH59_RS06855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LH59_RS06860	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LH59_RS06865	COG0372	Belongs to the citrate synthase family
LH59_RS06880	COG0280	phosphate acetyltransferase
LH59_RS06880	COG0281	malic enzyme
LH59_RS06890	COG1297	OPT oligopeptide transporter protein
LH59_RS06895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH59_RS06910	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LH59_RS06915	COG1522	sequence-specific DNA binding
LH59_RS06920	COG0567	Dehydrogenase, E1 component
LH59_RS06930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH59_RS06935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LH59_RS06940	COG1595	DNA-templated transcription, initiation
LH59_RS06985	COG2183	response to ionizing radiation
LH59_RS06990	COG1199	ATP-dependent helicase activity
LH59_RS07000	COG0564	pseudouridine synthase activity
LH59_RS07010	COG3243	poly(R)-hydroxyalkanoic acid synthase
LH59_RS07015	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS07020	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
LH59_RS07045	COG2831	hemolysin activation secretion protein
LH59_RS07060	COG2823	Periplasmic or secreted lipoprotein
LH59_RS07070	COG3237	CsbD-like
LH59_RS07075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH59_RS07075	COG0189	ligase activity
LH59_RS07080	COG0189	ligase activity
LH59_RS07080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH59_RS07085	COG1132	(ABC) transporter
LH59_RS07100	COG2833	Protein of unknown function (DUF455)
LH59_RS07105	COG2258	MOSC domain
LH59_RS07110	COG2951	lytic endotransglycosylase activity
LH59_RS07125	COG1960	acyl-CoA dehydrogenase activity
LH59_RS07135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LH59_RS07145	COG1696	Membrane protein involved in D-alanine export
LH59_RS07165	COG1215	transferase activity, transferring glycosyl groups
LH59_RS07175	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LH59_RS07195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH59_RS07210	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LH59_RS07220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH59_RS07230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LH59_RS07235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LH59_RS07255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LH59_RS07260	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LH59_RS07265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_RS07295	COG2951	lytic endotransglycosylase activity
LH59_RS07300	COG0123	including yeast histone deacetylase and acetoin utilization protein
LH59_RS07325	COG2985	domain, Protein
LH59_RS07330	COG1960	acyl-CoA dehydrogenase activity
LH59_RS07335	COG0450	alkyl hydroperoxide reductase
LH59_RS07345	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LH59_RS07350	COG4208	sulfate ABC transporter
LH59_RS07360	COG0175	sulfate reduction
LH59_RS07390	COG0335	large ribosomal subunit rRNA binding
LH59_RS07395	COG0494	nUDIX hydrolase
LH59_RS07400	COG1162	GTPase activity
LH59_RS07405	COG0501	Belongs to the peptidase M48B family
LH59_RS07410	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LH59_RS07415	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LH59_RS07420	COG3327	negative regulation of DNA-templated transcription, initiation
LH59_RS07425	COG3396	Phenylacetate-CoA oxygenase
LH59_RS07430	COG3460	Phenylacetate-CoA oxygenase
LH59_RS07435	COG3396	Phenylacetate-CoA oxygenase
LH59_RS07440	COG2151	metal-sulfur cluster biosynthetic enzyme
LH59_RS07445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LH59_RS07450	COG1012	belongs to the aldehyde dehydrogenase family
LH59_RS07455	COG1024	Enoyl-CoA hydratase
LH59_RS07460	COG2050	protein possibly involved in aromatic compounds catabolism
LH59_RS07470	COG0534	Mate efflux family protein
LH59_RS07485	COG3483	tryptophan 2,3-dioxygenase activity
LH59_RS07490	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
LH59_RS07495	COG2003	Belongs to the UPF0758 family
LH59_RS07505	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LH59_RS07510	COG0625	glutathione transferase activity
LH59_RS07515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH59_RS07540	COG0523	cobalamin synthesis protein
LH59_RS07545	COG0523	cobalamin synthesis protein
LH59_RS07550	COG0583	DNA-binding transcription factor activity
LH59_RS07560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LH59_RS07565	COG1187	pseudouridine synthase activity
LH59_RS07570	COG0779	Required for maturation of 30S ribosomal subunits
LH59_RS07575	COG2251	uridine kinase activity
LH59_RS07575	COG0195	Participates in both transcription termination and antitermination
LH59_RS07580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH59_RS07585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LH59_RS07590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LH59_RS07595	COG1217	gtp-binding protein TYPA
LH59_RS07615	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS07620	COG1473	amidohydrolase
LH59_RS07625	COG1611	Belongs to the LOG family
LH59_RS07640	COG0412	Dienelactone hydrolase
LH59_RS07655	COG1760	l-serine dehydratase
LH59_RS07660	COG0501	Belongs to the peptidase M48B family
LH59_RS07680	COG0583	DNA-binding transcription factor activity
LH59_RS07685	COG3842	ATPase activity
LH59_RS07695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH59_RS07700	COG1840	ABC-type Fe3 transport system, periplasmic component
LH59_RS07720	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS07730	COG1722	exodeoxyribonuclease VII activity
LH59_RS07735	COG0142	geranyltranstransferase activity
LH59_RS07745	COG1469	GTP cyclohydrolase I activity
LH59_RS07750	COG3739	integral membrane protein
LH59_RS07755	COG0360	Binds together with S18 to 16S ribosomal RNA
LH59_RS07760	COG2965	DNA replication, synthesis of RNA primer
LH59_RS07765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LH59_RS07770	COG0359	binds to the 23S rRNA
LH59_RS07780	COG0305	Participates in initiation and elongation during chromosome replication
LH59_RS07790	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LH59_RS07825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS07875	COG0540	Belongs to the ATCase OTCase family
LH59_RS07910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LH59_RS07915	COG2137	regulation of response to DNA damage stimulus
LH59_RS07940	COG0045	succinate-CoA ligase (ADP-forming) activity
LH59_RS07945	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LH59_RS07950	COG0861	Integral membrane protein TerC family
LH59_RS07955	COG0861	Integral membrane protein TerC family
LH59_RS07965	COG0181	hydroxymethylbilane synthase activity
LH59_RS07985	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LH59_RS07995	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS08025	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_RS08045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LH59_RS08050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH59_RS08060	COG0436	Aminotransferase
LH59_RS08080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LH59_RS08085	COG0308	aminopeptidase N
LH59_RS08100	COG0312	modulator of DNA gyrase
LH59_RS08105	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LH59_RS08110	COG0277	FAD linked oxidase domain protein
LH59_RS08115	COG0277	FAD linked oxidase domain protein
LH59_RS08120	COG0277	FAD linked oxidase domain protein
LH59_RS08125	COG0247	lactate metabolic process
LH59_RS08155	COG0583	DNA-binding transcription factor activity
LH59_RS08160	COG0482	sulfurtransferase activity
LH59_RS08165	COG0730	response to heat
LH59_RS08170	COG0625	glutathione transferase activity
LH59_RS08180	COG3909	cytochrome
LH59_RS08210	COG0628	permease
LH59_RS08220	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LH59_RS08340	COG0697	spore germination
LH59_RS08375	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LH59_RS08385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH59_RS08390	COG0069	glutamate synthase activity
LH59_RS08395	COG2391	methyltransferase activity
LH59_RS08400	COG0679	Auxin Efflux Carrier
LH59_RS08430	COG0557	exoribonuclease II activity
LH59_RS08435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH59_RS08445	COG3128	pkhd-type hydroxylase
LH59_RS08450	COG0776	regulation of translation
LH59_RS08480	COG0642	Histidine kinase
LH59_RS08485	COG3158	transport of potassium into the cell
LH59_RS08490	COG0137	argininosuccinate synthase activity
LH59_RS08505	COG3618	amidohydrolase
LH59_RS08525	COG0596	Alpha beta hydrolase
LH59_RS08525	COG2945	thiolester hydrolase activity
LH59_RS08530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LH59_RS08535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LH59_RS08545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_RS08545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LH59_RS08555	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_RS08560	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LH59_RS08570	COG3642	lipopolysaccharide core region biosynthetic process
LH59_RS08580	COG3842	ATPase activity
LH59_RS08585	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH59_RS08590	COG1177	transmembrane transport
LH59_RS08610	COG1322	Protein conserved in bacteria
LH59_RS08620	COG1960	acyl-CoA dehydrogenase activity
LH59_RS08630	COG0704	Plays a role in the regulation of phosphate uptake
LH59_RS08640	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LH59_RS08645	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LH59_RS08645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LH59_RS08650	COG1643	Atp-dependent helicase
LH59_RS08655	COG0395	ABC-type sugar transport system, permease component
LH59_RS08660	COG1116	anion transmembrane transporter activity
LH59_RS08675	COG0438	transferase activity, transferring glycosyl groups
LH59_RS08680	COG0726	polysaccharide deacetylase
LH59_RS08695	COG0726	polysaccharide deacetylase
LH59_RS08720	COG1132	(ABC) transporter
LH59_RS08725	COG0475	glutathione-regulated potassium exporter activity
LH59_RS08725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH59_RS08735	COG2203	Gaf domain
LH59_RS08735	COG3706	GGDEF domain
LH59_RS08735	COG4251	negative regulation of phosphorylation
LH59_RS08735	COG5001	Diguanylate cyclase
LH59_RS08745	COG1530	ribonuclease E activity
LH59_RS08775	COG2204	response regulator
LH59_RS08780	COG4191	Histidine kinase
LH59_RS08785	COG1301	dicarboxylic acid transport
LH59_RS08795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LH59_RS08800	COG0799	negative regulation of ribosome biogenesis
LH59_RS08805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LH59_RS08815	COG0151	Belongs to the GarS family
LH59_RS08820	COG0217	transcriptional regulatory protein
LH59_RS08825	COG0433	COG0433 Predicted ATPase
LH59_RS08830	COG0473	3-isopropylmalate dehydrogenase activity
LH59_RS08840	COG2814	Major facilitator Superfamily
LH59_RS08845	COG1566	PFAM secretion protein HlyD family protein
LH59_RS08855	COG1846	Transcriptional regulator
LH59_RS08885	COG3391	amine dehydrogenase activity
LH59_RS08895	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH59_RS08910	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LH59_RS08915	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LH59_RS08925	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LH59_RS08950	COG1309	transcriptional regulator
LH59_RS08955	COG2311	Membrane
LH59_RS08960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH59_RS08985	COG0662	Cupin 2, conserved barrel domain protein
LH59_RS08990	COG5285	phytanoyl-CoA dioxygenase
LH59_RS08995	COG0633	Ferredoxin
LH59_RS08995	COG3217	Mosc domain protein beta barrel domain protein
LH59_RS09000	COG2076	Multidrug Resistance protein
LH59_RS09015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_RS09030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LH59_RS09035	COG0425	Belongs to the sulfur carrier protein TusA family
LH59_RS09045	COG0228	four-way junction DNA binding
LH59_RS09055	COG0336	Belongs to the RNA methyltransferase TrmD family
LH59_RS09060	COG1396	sequence-specific DNA binding
LH59_RS09065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS09070	COG0765	amino acid transport
LH59_RS09075	COG1126	abc transporter atp-binding protein
LH59_RS09080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_RS09085	COG0525	valine-tRNA ligase activity
LH59_RS09090	COG0105	UTP biosynthetic process
LH59_RS09095	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LH59_RS09115	COG2976	Protein conserved in bacteria
LH59_RS09120	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH59_RS09125	COG1160	GTP binding
LH59_RS09130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH59_RS09135	COG1923	regulation of RNA biosynthetic process
LH59_RS09140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LH59_RS09145	COG0330	HflC and HflK could
LH59_RS09150	COG0330	HflC and HflK could
LH59_RS09155	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LH59_RS09160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LH59_RS09165	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LH59_RS09170	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LH59_RS09190	COG0438	transferase activity, transferring glycosyl groups
LH59_RS09200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH59_RS09200	COG2755	lipolytic protein G-D-S-L family
LH59_RS09230	COG4964	Belongs to the GSP D family
LH59_RS09260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LH59_RS09270	COG1295	ribonuclease BN
LH59_RS09280	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LH59_RS09305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LH59_RS09335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_RS09340	COG2274	protein secretion by the type I secretion system
LH59_RS09350	COG1538	Outer membrane efflux protein
LH59_RS09370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LH59_RS09380	COG0101	tRNA pseudouridine synthase activity
LH59_RS09385	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LH59_RS09405	COG0596	Alpha beta hydrolase
LH59_RS09440	COG0129	dihydroxy-acid dehydratase activity
LH59_RS09445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_RS09450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_RS09455	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LH59_RS09460	COG1609	Transcriptional regulator
LH59_RS09485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS09490	COG0601	transmembrane transport
LH59_RS09500	COG1012	belongs to the aldehyde dehydrogenase family
LH59_RS09530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH59_RS09535	COG2197	response regulator
LH59_RS09545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LH59_RS09550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LH59_RS09565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH59_RS09570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LH59_RS09575	COG0004	ammonium transporteR
LH59_RS09580	COG0347	Belongs to the P(II) protein family
LH59_RS09590	COG2960	long-chain fatty acid transporting porin activity
LH59_RS09605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LH59_RS09610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LH59_RS09615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LH59_RS09620	COG0072	phenylalanine-tRNA ligase activity
LH59_RS09620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH59_RS09650	COG2814	Major facilitator Superfamily
LH59_RS09675	COG0384	phenazine biosynthesis protein PhzF
LH59_RS09680	COG0456	acetyltransferase
LH59_RS09715	COG1522	sequence-specific DNA binding
LH59_RS09745	COG0583	DNA-binding transcription factor activity
LH59_RS09750	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS09775	COG1116	anion transmembrane transporter activity
LH59_RS09805	COG5265	(ABC) transporter
LH59_RS09810	COG0656	L-ascorbic acid biosynthetic process
LH59_RS09825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LH59_RS09835	COG1917	Cupin 2, conserved barrel domain protein
LH59_RS09835	COG4977	sequence-specific DNA binding
LH59_RS09840	COG2223	nitrite transmembrane transporter activity
LH59_RS09850	COG1215	transferase activity, transferring glycosyl groups
LH59_RS09855	COG1649	PFAM Uncharacterised BCR, COG1649
LH59_RS09855	COG0726	polysaccharide deacetylase
LH59_RS09860	COG0457	Tetratricopeptide repeat
LH59_RS09890	COG1610	YqeY-like protein
LH59_RS09895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH59_RS09900	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS09940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH59_RS09950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH59_RS09955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH59_RS09980	COG1959	2 iron, 2 sulfur cluster binding
LH59_RS09985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_RS09990	COG0697	spore germination
LH59_RS09995	COG0506	proline dehydrogenase activity
LH59_RS10015	COG0583	DNA-binding transcription factor activity
LH59_RS10025	COG0625	glutathione transferase activity
LH59_RS10045	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LH59_RS10060	COG1960	acyl-CoA dehydrogenase activity
LH59_RS10065	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS10095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH59_RS10105	COG3245	cytochrome
LH59_RS10110	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LH59_RS10125	COG1280	lysine exporter protein (LysE YggA)
LH59_RS10140	COG0697	spore germination
LH59_RS10145	COG0697	spore germination
LH59_RS10160	COG0534	Mate efflux family protein
LH59_RS10165	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LH59_RS10170	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS10180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH59_RS10185	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LH59_RS10195	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS10230	COG2207	Transcriptional regulator
LH59_RS10240	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS10245	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS10250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH59_RS10255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH59_RS10265	COG1304	FMN binding
LH59_RS10285	COG3712	iron ion homeostasis
LH59_RS10290	COG1595	DNA-templated transcription, initiation
LH59_RS10320	COG3088	subunit of a heme lyase
LH59_RS10335	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LH59_RS10355	COG4133	protoheme IX ABC transporter activity
LH59_RS10390	COG4235	cytochrome complex assembly
LH59_RS10400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_RS10410	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LH59_RS10430	COG4133	protoheme IX ABC transporter activity
LH59_RS10435	COG3005	denitrification pathway
LH59_RS10440	COG3043	anaerobic respiration
LH59_RS10460	COG3246	L-lysine catabolic process to acetate
LH59_RS10465	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_RS10470	COG0583	DNA-binding transcription factor activity
LH59_RS10480	COG0129	dihydroxy-acid dehydratase activity
LH59_RS10485	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS10490	COG5001	Diguanylate cyclase
LH59_RS10495	COG1024	Enoyl-CoA hydratase
LH59_RS10525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_RS10535	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
LH59_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS10545	COG0583	DNA-binding transcription factor activity
LH59_RS10550	COG2610	gluconate transmembrane transporter activity
LH59_RS10590	COG0235	Class ii aldolase
LH59_RS10595	COG0477	Major facilitator Superfamily
LH59_RS10610	COG2188	Transcriptional regulator
LH59_RS10615	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS10655	COG1280	lysine exporter protein (LysE YggA)
LH59_RS10660	COG5265	(ABC) transporter
LH59_RS10670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_RS10685	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS10690	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS10725	COG0583	DNA-binding transcription factor activity
LH59_RS10735	COG0583	DNA-binding transcription factor activity
LH59_RS10745	COG0583	DNA-binding transcription factor activity
LH59_RS10770	COG2226	methyltransferase
LH59_RS10780	COG2814	Major facilitator Superfamily
LH59_RS10785	COG0154	amidase activity
LH59_RS10825	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS10835	COG1012	belongs to the aldehyde dehydrogenase family
LH59_RS10840	COG0307	riboflavin synthase, alpha
LH59_RS10850	COG2271	Major facilitator Superfamily
LH59_RS10860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH59_RS10870	COG0789	Transcriptional regulator
LH59_RS10895	COG4774	siderophore transport
LH59_RS10905	COG0022	dehydrogenase e1 component
LH59_RS10925	COG0165	Argininosuccinate lyase
LH59_RS10930	COG0668	transmembrane transport
LH59_RS11000	COG2165	general secretion pathway protein
LH59_RS11035	COG0583	DNA-binding transcription factor activity
LH59_RS11045	COG0747	negative chemotaxis
LH59_RS11050	COG0601	transmembrane transport
LH59_RS11055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS11060	COG4172	Belongs to the ABC transporter superfamily
LH59_RS11065	COG4681	YaeQ
LH59_RS11080	COG0477	Major facilitator Superfamily
LH59_RS11085	COG3161	chorismate lyase activity
LH59_RS11090	COG1187	pseudouridine synthase activity
LH59_RS11095	COG0583	DNA-binding transcription factor activity
LH59_RS11120	COG1999	signal sequence binding
LH59_RS11130	COG0339	signal peptide processing
LH59_RS11135	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LH59_RS11140	COG4566	intracellular signal transduction
LH59_RS11150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LH59_RS11155	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH59_RS11160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH59_RS11170	COG0583	DNA-binding transcription factor activity
LH59_RS11195	COG1191	sigma factor activity
LH59_RS11215	COG1360	Flagellar Motor Protein
LH59_RS11220	COG0745	RESPONSE REGULATOR receiver
LH59_RS11230	COG0835	chemotaxis
LH59_RS11235	COG0840	transmembrane signaling receptor activity
LH59_RS11240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LH59_RS11245	COG2201	protein-glutamate methylesterase activity
LH59_RS11250	COG0745	RESPONSE REGULATOR receiver
LH59_RS11255	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LH59_RS11260	COG0840	transmembrane signaling receptor activity
LH59_RS11285	COG2747	anti-sigma28 factor FlgM
LH59_RS11295	COG1815	bacterial-type flagellum-dependent cell motility
LH59_RS11300	COG1558	bacterial-type flagellum-dependent cell motility
LH59_RS11315	COG4787	bacterial-type flagellum-dependent cell motility
LH59_RS11350	COG0840	transmembrane signaling receptor activity
LH59_RS11360	COG0840	transmembrane signaling receptor activity
LH59_RS11365	COG0840	transmembrane signaling receptor activity
LH59_RS11400	COG1580	Controls the rotational direction of flagella during chemotaxis
LH59_RS11425	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH59_RS11430	COG1766	The M ring may be actively involved in energy transduction
LH59_RS11435	COG1677	Flagellar hook-basal body complex protein FliE
LH59_RS11445	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LH59_RS11465	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LH59_RS11470	COG1334	flagellar protein FlaG
LH59_RS11475	COG1414	Transcriptional regulator
LH59_RS11485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_RS11490	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS11500	COG0285	dihydrofolate synthase activity
LH59_RS11520	COG1451	nucleotide metabolic process
LH59_RS11525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LH59_RS11535	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LH59_RS11540	COG0024	Methionine aminopeptidase
LH59_RS11545	COG0052	Belongs to the universal ribosomal protein uS2 family
LH59_RS11550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LH59_RS11555	COG0528	UMP kinase activity
LH59_RS11560	COG0233	cytoplasmic translational termination
LH59_RS11565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LH59_RS11575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LH59_RS11580	COG0750	zinc metalloprotease
LH59_RS11585	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH59_RS11590	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LH59_RS11595	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH59_RS11600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH59_RS11615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LH59_RS11620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH59_RS11640	COG2169	Transcriptional regulator
LH59_RS11640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH59_RS11645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH59_RS11645	COG0519	Catalyzes the synthesis of GMP from XMP
LH59_RS11665	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LH59_RS11670	COG2867	negative regulation of translational initiation
LH59_RS11675	COG2914	Belongs to the UPF0125 (RnfH) family
LH59_RS11685	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_RS11685	COG1024	Enoyl-CoA hydratase
LH59_RS11710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LH59_RS11715	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LH59_RS11720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LH59_RS11725	COG0084	hydrolase, TatD family'
LH59_RS11740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS11745	COG0765	amino acid transport
LH59_RS11750	COG1126	abc transporter atp-binding protein
LH59_RS11755	COG0010	Belongs to the arginase family
LH59_RS11765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LH59_RS11775	COG0095	Lipoate-protein ligase
LH59_RS11790	COG0625	glutathione transferase activity
LH59_RS11800	COG1522	sequence-specific DNA binding
LH59_RS11805	COG0386	Belongs to the glutathione peroxidase family
LH59_RS11810	COG2814	Major facilitator Superfamily
LH59_RS11830	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LH59_RS11840	COG0840	transmembrane signaling receptor activity
LH59_RS11850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_RS11880	COG1902	pentaerythritol trinitrate reductase activity
LH59_RS11910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LH59_RS11925	COG0842	Transport permease protein
LH59_RS11930	COG1131	(ABC) transporter
LH59_RS11945	COG2130	NADP-dependent
LH59_RS11970	COG3842	ATPase activity
LH59_RS11975	COG3842	ATPase activity
LH59_RS11985	COG0395	ABC-type sugar transport system, permease component
LH59_RS12030	COG0346	lactoylglutathione lyase activity
LH59_RS12035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_RS12055	COG3634	alkyl hydroperoxide reductase activity
LH59_RS12060	COG1959	2 iron, 2 sulfur cluster binding
LH59_RS12065	COG1960	acyl-CoA dehydrogenase activity
LH59_RS12100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_RS12105	COG0420	3'-5' exonuclease activity
LH59_RS12130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LH59_RS12130	COG2111	Na H antiporter
LH59_RS12135	COG1006	Multisubunit Na H antiporter MnhC subunit
LH59_RS12140	COG0651	ATP synthesis coupled electron transport
LH59_RS12145	COG1863	multisubunit Na H antiporter MnhE subunit
LH59_RS12150	COG2212	antiporter activity
LH59_RS12155	COG1320	monovalent cation:proton antiporter activity
LH59_RS12175	COG1619	proteins homologs of microcin C7 resistance protein MccF
LH59_RS12180	COG0488	(ABC) transporter
LH59_RS12215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_RS12220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH59_RS12230	COG2252	PERMEase
LH59_RS12235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LH59_RS12240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LH59_RS12250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LH59_RS12275	COG0583	DNA-binding transcription factor activity
LH59_RS12280	COG2814	Major facilitator Superfamily
LH59_RS12285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH59_RS12290	COG0789	Transcriptional regulator
LH59_RS12305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH59_RS12305	COG0678	peroxiredoxin activity
LH59_RS12315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LH59_RS12320	COG0584	glycerophosphoryl diester phosphodiesterase
LH59_RS12330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_RS12340	COG4181	ATPase activity
LH59_RS12350	COG1178	ABC-type Fe3 transport system permease component
LH59_RS12355	COG3842	ATPase activity
LH59_RS12360	COG0583	DNA-binding transcription factor activity
LH59_RS12365	COG0560	Phosphoserine phosphatase
LH59_RS12380	COG0583	DNA-binding transcription factor activity
LH59_RS12395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_RS12410	COG0583	DNA-binding transcription factor activity
LH59_RS12415	COG4336	lyase activity
LH59_RS12445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_RS12465	COG2816	NAD+ diphosphatase activity
LH59_RS12485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS12490	COG0765	amino acid transport
LH59_RS12495	COG1126	abc transporter atp-binding protein
LH59_RS12500	COG1335	isochorismatase
LH59_RS12510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LH59_RS12515	COG1758	RNA polymerase activity
LH59_RS12520	COG0194	GDP metabolic process
LH59_RS12525	COG3258	Cytochrome c
LH59_RS12530	COG2863	cytochrome
LH59_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS12540	COG2831	hemolysin activation secretion protein
LH59_RS12545	COG3210	domain, Protein
LH59_RS12550	COG0791	NLP P60 protein
LH59_RS12565	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LH59_RS12570	COG0833	amino acid
LH59_RS12575	COG1561	YicC-like family, N-terminal region
LH59_RS12580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LH59_RS12590	COG1960	acyl-CoA dehydrogenase activity
LH59_RS12605	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LH59_RS12610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH59_RS12615	COG0174	glutamine synthetase
LH59_RS12625	COG2204	response regulator
LH59_RS12630	COG0583	DNA-binding transcription factor activity
LH59_RS12635	COG1741	Belongs to the pirin family
LH59_RS12640	COG1741	Belongs to the pirin family
LH59_RS12645	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS12650	COG3842	ATPase activity
LH59_RS12655	COG4149	molybdate abc transporter
LH59_RS12660	COG1840	ABC-type Fe3 transport system, periplasmic component
LH59_RS12670	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS12680	COG0583	DNA-binding transcription factor activity
LH59_RS12690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LH59_RS12700	COG0783	Belongs to the Dps family
LH59_RS12710	COG0457	Tetratricopeptide repeat
LH59_RS12715	COG0438	transferase activity, transferring glycosyl groups
LH59_RS12740	COG1560	Kdo2-lipid A biosynthetic process
LH59_RS12740	COG4783	chaperone-mediated protein folding
LH59_RS12745	COG3866	Pectate lyase
LH59_RS12760	COG0745	RESPONSE REGULATOR receiver
LH59_RS12765	COG2205	protein histidine kinase activity
LH59_RS12780	COG3842	ATPase activity
LH59_RS12785	COG0395	ABC-type sugar transport system, permease component
LH59_RS12790	COG1175	transmembrane transport
LH59_RS12795	COG1653	transport
LH59_RS12805	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LH59_RS12815	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_RS12840	COG1794	racemase activity, acting on amino acids and derivatives
LH59_RS12845	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LH59_RS12855	COG0583	DNA-binding transcription factor activity
LH59_RS12860	COG0625	glutathione transferase activity
LH59_RS12865	COG2133	pyrroloquinoline quinone binding
LH59_RS12875	COG0697	spore germination
LH59_RS12880	COG2363	Small membrane protein
LH59_RS12900	COG0010	Belongs to the arginase family
LH59_RS12905	COG1464	Belongs to the NlpA lipoprotein family
LH59_RS12915	COG2814	Major facilitator Superfamily
LH59_RS12925	COG1408	metallophosphoesterase
LH59_RS12935	COG0688	phosphatidylethanolamine metabolic process
LH59_RS12940	COG0488	(ABC) transporter
LH59_RS12965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_RS12970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LH59_RS12975	COG5001	Diguanylate cyclase
LH59_RS12975	COG3300	MHYT domain
LH59_RS12990	COG2814	Major facilitator Superfamily
LH59_RS13015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LH59_RS13020	COG2204	response regulator
LH59_RS13050	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS13070	COG0693	protein deglycase activity
LH59_RS13085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH59_RS13100	COG5001	Diguanylate cyclase
LH59_RS13100	COG3300	MHYT domain
LH59_RS13115	COG4774	siderophore transport
LH59_RS13150	COG1253	flavin adenine dinucleotide binding
LH59_RS13160	COG2205	protein histidine kinase activity
LH59_RS13325	COG0789	Transcriptional regulator
LH59_RS13335	COG3706	GGDEF domain
LH59_RS13365	COG1116	anion transmembrane transporter activity
LH59_RS13370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS13375	COG4521	taurine ABC transporter
LH59_RS13395	COG0793	Belongs to the peptidase S41A family
LH59_RS13415	COG0628	permease
LH59_RS13425	COG1619	proteins homologs of microcin C7 resistance protein MccF
LH59_RS13440	COG0531	amino acid
LH59_RS13450	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LH59_RS13455	COG4608	Belongs to the ABC transporter superfamily
LH59_RS13460	COG0444	Belongs to the ABC transporter superfamily
LH59_RS13470	COG0601	transmembrane transport
LH59_RS13475	COG0747	negative chemotaxis
LH59_RS13485	COG0251	oxidation-reduction process
LH59_RS13505	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH59_RS13520	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LH59_RS13535	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH59_RS13545	COG3971	2-oxopent-4-enoate hydratase activity
LH59_RS13575	COG0625	glutathione transferase activity
LH59_RS13590	COG0477	Major facilitator Superfamily
LH59_RS13600	COG0579	oxidoreductase
LH59_RS13615	COG0625	glutathione transferase activity
LH59_RS13630	COG0431	NADPH-dependent FMN reductase
LH59_RS13640	COG0798	PFAM Bile acid sodium symporter
LH59_RS13650	COG0640	Transcriptional regulator
LH59_RS13660	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LH59_RS13680	COG1126	abc transporter atp-binding protein
LH59_RS13685	COG0765	amino acid transport
LH59_RS13690	COG4597	amino acid ABC transporter
LH59_RS13695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS13700	COG0626	cystathionine gamma-synthase activity
LH59_RS13705	COG0583	DNA-binding transcription factor activity
LH59_RS13725	COG0444	Belongs to the ABC transporter superfamily
LH59_RS13735	COG0601	transmembrane transport
LH59_RS13740	COG0747	negative chemotaxis
LH59_RS13750	COG0583	DNA-binding transcription factor activity
LH59_RS13755	COG1335	isochorismatase
LH59_RS13760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH59_RS13770	COG2358	TRAP transporter, solute receptor (TAXI family
LH59_RS13775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS13780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS13790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH59_RS13795	COG0519	Catalyzes the synthesis of GMP from XMP
LH59_RS13795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH59_RS13805	COG1276	copper resistance
LH59_RS13825	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS13830	COG3386	PFAM SMP-30 Gluconolaconase
LH59_RS13835	COG2721	sulfolactate sulfo-lyase activity
LH59_RS13855	COG0745	RESPONSE REGULATOR receiver
LH59_RS13865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_RS13870	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
LH59_RS13875	COG3842	ATPase activity
LH59_RS13880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LH59_RS13895	COG0586	Pfam SNARE associated Golgi protein
LH59_RS13900	COG0390	transport system, permease component
LH59_RS13910	COG3486	L-lysine 6-monooxygenase (NADPH) activity
LH59_RS13955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_RS13960	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_RS13965	COG1120	ATPase activity
LH59_RS13970	COG1126	abc transporter atp-binding protein
LH59_RS13975	COG0765	amino acid transport
LH59_RS13980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS13985	COG2070	2-Nitropropane dioxygenase
LH59_RS13990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_RS14000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH59_RS14025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LH59_RS14030	COG0583	DNA-binding transcription factor activity
LH59_RS14040	COG1846	Transcriptional regulator
LH59_RS14050	COG4191	Histidine kinase
LH59_RS14055	COG4566	intracellular signal transduction
LH59_RS14085	COG0583	DNA-binding transcription factor activity
LH59_RS14105	COG1126	abc transporter atp-binding protein
LH59_RS14115	COG0765	amino acid transport
LH59_RS14120	COG0436	Aminotransferase
LH59_RS14145	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LH59_RS14170	COG0251	oxidation-reduction process
LH59_RS14210	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_RS14220	COG1802	Transcriptional regulator
LH59_RS14225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_RS14240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH59_RS14265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS14270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_RS14275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_RS14275	COG1116	anion transmembrane transporter activity
LH59_RS14310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS14315	COG4597	amino acid ABC transporter
LH59_RS14320	COG3154	lipid carrier protein
LH59_RS14325	COG0826	peptidase U32
LH59_RS14330	COG0826	peptidase U32
LH59_RS14335	COG2197	response regulator
LH59_RS14340	COG3850	Histidine kinase
LH59_RS14345	COG1763	Mo-molybdopterin cofactor biosynthetic process
LH59_RS14350	COG0288	reversible hydration of carbon dioxide
LH59_RS14355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LH59_RS14360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_RS14365	COG2181	nitrate reductase activity
LH59_RS14370	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LH59_RS14375	COG1140	nitrate reductase beta subunit
LH59_RS14380	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LH59_RS14385	COG2223	nitrite transmembrane transporter activity
LH59_RS14430	COG0583	DNA-binding transcription factor activity
LH59_RS14440	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS14470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS14490	COG2070	2-Nitropropane dioxygenase
LH59_RS14505	COG5002	protein histidine kinase activity
LH59_RS14510	COG0745	RESPONSE REGULATOR receiver
LH59_RS14515	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
LH59_RS14520	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LH59_RS14530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH59_RS14535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH59_RS14550	COG0783	Belongs to the Dps family
LH59_RS14580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS14585	COG0697	spore germination
LH59_RS14590	COG2879	small protein
LH59_RS14595	COG1966	Carbon starvation protein
LH59_RS14620	COG0583	DNA-binding transcription factor activity
LH59_RS14625	COG4521	taurine ABC transporter
LH59_RS14630	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LH59_RS14635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS14650	COG3712	iron ion homeostasis
LH59_RS14655	COG1595	DNA-templated transcription, initiation
LH59_RS14660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS14680	COG0235	Class ii aldolase
LH59_RS14685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_RS14695	COG0523	cobalamin synthesis protein
LH59_RS14700	COG1228	amidohydrolase
LH59_RS14705	COG4172	Belongs to the ABC transporter superfamily
LH59_RS14710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS14715	COG0601	transmembrane transport
LH59_RS14720	COG0747	negative chemotaxis
LH59_RS14735	COG1414	Transcriptional regulator
LH59_RS14740	COG0513	Belongs to the DEAD box helicase family
LH59_RS14745	COG0602	queuosine metabolic process
LH59_RS14750	COG0720	synthase
LH59_RS14760	COG1289	transmembrane transporter activity
LH59_RS14770	COG1566	PFAM secretion protein HlyD family protein
LH59_RS14785	COG0028	Belongs to the TPP enzyme family
LH59_RS14795	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS14805	COG0400	carboxylic ester hydrolase activity
LH59_RS14810	COG0833	amino acid
LH59_RS14830	COG0587	DNA-directed DNA polymerase activity
LH59_RS14850	COG0667	Aldo Keto reductase
LH59_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS14860	COG0583	DNA-binding transcription factor activity
LH59_RS14870	COG3038	cytochrome b561
LH59_RS14890	COG0840	transmembrane signaling receptor activity
LH59_RS14955	COG2764	glyoxalase bleomycin resistance protein dioxygenase
LH59_RS14975	COG4774	siderophore transport
LH59_RS14980	COG2345	Transcriptional regulator
LH59_RS14990	COG1414	Transcriptional regulator
LH59_RS15000	COG0477	Major facilitator Superfamily
LH59_RS15005	COG0667	Aldo Keto reductase
LH59_RS15015	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS15020	COG1309	transcriptional regulator
LH59_RS15040	COG1683	Conserved Protein
LH59_RS15050	COG2207	Transcriptional regulator
LH59_RS15070	COG2885	chlorophyll binding
LH59_RS15070	COG3047	cAMP biosynthetic process
LH59_RS15085	COG3795	YCII-related domain
LH59_RS15090	COG3795	YCII-related domain
LH59_RS15100	COG4941	Belongs to the sigma-70 factor family
LH59_RS15110	COG0697	spore germination
LH59_RS15115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH59_RS15125	COG0583	DNA-binding transcription factor activity
LH59_RS15155	COG1846	Transcriptional regulator
LH59_RS15160	COG3541	Predicted nucleotidyltransferase
LH59_RS15180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_RS15210	COG1360	Flagellar Motor Protein
LH59_RS15220	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
LH59_RS15395	COG0625	glutathione transferase activity
LH59_RS15400	COG2032	superoxide dismutase activity
LH59_RS15405	COG2733	membrane
LH59_RS15415	COG0148	phosphopyruvate hydratase activity
LH59_RS15440	COG0583	DNA-binding transcription factor activity
LH59_RS15450	COG0183	Belongs to the thiolase family
LH59_RS15455	COG1960	acyl-CoA dehydrogenase activity
LH59_RS15460	COG1960	acyl-CoA dehydrogenase activity
LH59_RS15465	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS15475	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LH59_RS15490	COG0583	DNA-binding transcription factor activity
LH59_RS15500	COG1846	Transcriptional regulator
LH59_RS15505	COG0477	Major facilitator Superfamily
LH59_RS15510	COG2010	Cytochrome c
LH59_RS15510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LH59_RS15520	COG2080	2 iron, 2 sulfur cluster binding
LH59_RS15530	COG0596	Alpha beta hydrolase
LH59_RS15535	COG2309	aminopeptidase activity
LH59_RS15540	COG1335	isochorismatase
LH59_RS15545	COG2010	Cytochrome c
LH59_RS15545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LH59_RS15555	COG1522	sequence-specific DNA binding
LH59_RS15560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_RS15565	COG3842	ATPase activity
LH59_RS15570	COG1840	ABC-type Fe3 transport system, periplasmic component
LH59_RS15575	COG4149	molybdate abc transporter
LH59_RS15580	COG2203	Gaf domain
LH59_RS15580	COG4251	negative regulation of phosphorylation
LH59_RS15580	COG3706	GGDEF domain
LH59_RS15580	COG5001	Diguanylate cyclase
LH59_RS15585	COG2201	protein-glutamate methylesterase activity
LH59_RS15610	COG0840	transmembrane signaling receptor activity
LH59_RS15615	COG0154	amidase activity
LH59_RS15630	COG0583	DNA-binding transcription factor activity
LH59_RS15660	COG0456	acetyltransferase
LH59_RS15675	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS15705	COG0477	Major facilitator Superfamily
LH59_RS15735	COG0165	Argininosuccinate lyase
LH59_RS15750	COG0583	DNA-binding transcription factor activity
LH59_RS15765	COG2205	protein histidine kinase activity
LH59_RS15775	COG2267	carboxylic ester hydrolase activity
LH59_RS15785	COG4221	oxidoreductase activity
LH59_RS15790	COG2207	Transcriptional regulator
LH59_RS15820	COG0640	Transcriptional regulator
LH59_RS15825	COG0640	Transcriptional regulator
LH59_RS15835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LH59_RS15840	COG0583	DNA-binding transcription factor activity
LH59_RS15845	COG0431	NADPH-dependent FMN reductase
LH59_RS15875	COG4264	IucA IucC family
LH59_RS15905	COG0519	Catalyzes the synthesis of GMP from XMP
LH59_RS15905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH59_RS15935	COG0583	DNA-binding transcription factor activity
LH59_RS15945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH59_RS15970	COG0583	DNA-binding transcription factor activity
LH59_RS15975	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS16015	COG2072	flavoprotein involved in K transport
LH59_RS16020	COG0601	transmembrane transport
LH59_RS16025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS16035	COG4608	Belongs to the ABC transporter superfamily
LH59_RS16040	COG0747	negative chemotaxis
LH59_RS16055	COG0583	DNA-binding transcription factor activity
LH59_RS16060	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS16065	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LH59_RS16070	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS16115	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH59_RS16140	COG0583	DNA-binding transcription factor activity
LH59_RS16190	COG5001	Diguanylate cyclase
LH59_RS16195	COG4774	siderophore transport
LH59_RS16210	COG0583	DNA-binding transcription factor activity
LH59_RS16260	COG1953	Uracil, thiamine, allantoin
LH59_RS16295	COG0583	DNA-binding transcription factor activity
LH59_RS16300	COG0784	Response regulator, receiver
LH59_RS16300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS16300	COG2198	Histidine kinase
LH59_RS16300	COG2205	protein histidine kinase activity
LH59_RS16305	COG3292	Two component regulator propeller
LH59_RS16305	COG2205	protein histidine kinase activity
LH59_RS16305	COG0745	RESPONSE REGULATOR receiver
LH59_RS16330	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS16335	COG0583	DNA-binding transcription factor activity
LH59_RS16340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_RS16350	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS16360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LH59_RS16370	COG0583	DNA-binding transcription factor activity
LH59_RS16385	COG0642	Histidine kinase
LH59_RS16410	COG0047	phosphoribosylformylglycinamidine synthase activity
LH59_RS16410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LH59_RS16420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_RS16420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LH59_RS16425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_RS16435	COG0613	PHP domain protein
LH59_RS16450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LH59_RS16460	COG0583	DNA-binding transcription factor activity
LH59_RS16470	COG0583	DNA-binding transcription factor activity
LH59_RS16475	COG0477	Major facilitator Superfamily
LH59_RS16480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH59_RS16490	COG0159	tryptophan synthase activity
LH59_RS16500	COG0583	DNA-binding transcription factor activity
LH59_RS16520	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS16530	COG3119	arylsulfatase activity
LH59_RS16570	COG2149	membrane
LH59_RS16580	COG3093	addiction module antidote protein HigA
LH59_RS16605	COG2249	NAD(P)H dehydrogenase (quinone) activity
LH59_RS16615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LH59_RS16620	COG0459	protein refolding
LH59_RS16655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LH59_RS16660	COG0714	Associated with various cellular activities
LH59_RS16680	COG2304	oxidoreductase activity
LH59_RS16695	COG3119	arylsulfatase activity
LH59_RS16705	COG1280	lysine exporter protein (LysE YggA)
LH59_RS16735	COG0633	Ferredoxin
LH59_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS16745	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS16750	COG4133	protoheme IX ABC transporter activity
LH59_RS16755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH59_RS16795	COG4604	ABC transporter, ATP-binding protein
LH59_RS16800	COG4605	iron ion homeostasis
LH59_RS16805	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_RS16810	COG4607	ABC-type enterochelin transport system periplasmic component
LH59_RS16815	COG4771	TonB-dependent receptor
LH59_RS16820	COG0745	RESPONSE REGULATOR receiver
LH59_RS16830	COG0084	hydrolase, TatD family'
LH59_RS16835	COG1136	(ABC) transporter
LH59_RS16855	COG2271	Major facilitator Superfamily
LH59_RS16860	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LH59_RS16865	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS16870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LH59_RS16885	COG3135	benzoate transporter
LH59_RS16890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LH59_RS16895	COG1309	transcriptional regulator
LH59_RS16900	COG0183	Belongs to the thiolase family
LH59_RS16905	COG1022	Amp-dependent synthetase and ligase
LH59_RS16930	COG1024	Enoyl-CoA hydratase
LH59_RS16940	COG1803	Methylglyoxal synthase
LH59_RS16945	COG2975	iron-sulfur cluster assembly
LH59_RS16950	COG0633	Ferredoxin
LH59_RS16955	COG0443	Heat shock 70 kDa protein
LH59_RS16960	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LH59_RS16965	COG0316	Belongs to the HesB IscA family
LH59_RS16970	COG0822	iron-sulfur transferase activity
LH59_RS16975	COG1104	cysteine desulfurase activity
LH59_RS16985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LH59_RS16990	COG0556	nucleotide-excision repair
LH59_RS17000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LH59_RS17005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LH59_RS17010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LH59_RS17015	COG0740	serine-type endopeptidase activity
LH59_RS17020	COG0544	peptidyl-prolyl cis-trans isomerase activity
LH59_RS17025	COG0501	Belongs to the peptidase M48B family
LH59_RS17035	COG1278	Cold shock
LH59_RS17045	COG1278	Cold shock
LH59_RS17070	COG0251	oxidation-reduction process
LH59_RS17080	COG0583	DNA-binding transcription factor activity
LH59_RS17115	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LH59_RS17140	COG0277	FAD linked oxidase domain protein
LH59_RS17155	COG2814	Major facilitator Superfamily
LH59_RS17290	COG0740	serine-type endopeptidase activity
LH59_RS17375	COG2171	N-acyltransferase activity
LH59_RS17385	COG2890	protein-(glutamine-N5) methyltransferase activity
LH59_RS17390	COG0488	(ABC) transporter
LH59_RS17405	COG4771	TonB-dependent receptor
LH59_RS17410	COG4771	TonB-dependent receptor
LH59_RS17420	COG1858	cytochrome C peroxidase
LH59_RS17430	COG0210	DNA helicase
LH59_RS17445	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH59_RS17445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH59_RS17450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LH59_RS17455	COG0196	riboflavin kinase activity
LH59_RS17460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LH59_RS17465	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LH59_RS17470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LH59_RS17520	COG1902	pentaerythritol trinitrate reductase activity
LH59_RS17525	COG1126	abc transporter atp-binding protein
LH59_RS17530	COG0765	amino acid transport
LH59_RS17535	COG0765	amino acid transport
LH59_RS17540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS17550	COG2423	ornithine cyclodeaminase activity
LH59_RS17555	COG1764	response to oxidative stress
LH59_RS17565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH59_RS17570	COG0625	glutathione transferase activity
LH59_RS17590	COG2271	Major facilitator Superfamily
LH59_RS17620	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LH59_RS17620	COG0506	proline dehydrogenase activity
LH59_RS17620	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LH59_RS17630	COG3008	intermembrane lipid transfer
LH59_RS17635	COG2995	paraquat-inducible protein a
LH59_RS17645	COG4953	penicillin-binding protein 1C
LH59_RS17650	COG2373	Large extracellular alpha-helical protein
LH59_RS17655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LH59_RS17660	COG1278	Cold shock
LH59_RS17670	COG0183	Belongs to the thiolase family
LH59_RS17675	COG0038	chloride channel
LH59_RS17685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LH59_RS17695	COG1570	exodeoxyribonuclease VII activity
LH59_RS17700	COG0811	peptide transport
LH59_RS17710	COG1663	tetraacyldisaccharide 4'-kinase activity
LH59_RS17720	COG2835	tetraacyldisaccharide 4'-kinase activity
LH59_RS17725	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LH59_RS17730	COG0563	adenylate kinase activity
LH59_RS17740	COG0728	peptidoglycan biosynthetic process
LH59_RS17750	COG0268	Binds directly to 16S ribosomal RNA
LH59_RS17755	COG0583	DNA-binding transcription factor activity
LH59_RS17770	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS17775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LH59_RS17780	COG2186	Transcriptional regulator
LH59_RS17790	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS17800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH59_RS17830	COG3384	dioxygenase
LH59_RS17835	COG1012	belongs to the aldehyde dehydrogenase family
LH59_RS17850	COG3971	2-oxopent-4-enoate hydratase activity
LH59_RS17860	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS17865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LH59_RS17870	COG1562	ergosterol biosynthetic process
LH59_RS17875	COG1562	ergosterol biosynthetic process
LH59_RS17885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LH59_RS17915	COG5564	TIM-barrel signal transduction protein
LH59_RS17920	COG5441	Belongs to the UPF0261 family
LH59_RS17945	COG0542	response to heat
LH59_RS17955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH59_RS17965	COG0477	Major facilitator Superfamily
LH59_RS17980	COG0494	nUDIX hydrolase
LH59_RS17985	COG0583	DNA-binding transcription factor activity
LH59_RS17990	COG0443	Heat shock 70 kDa protein
LH59_RS18025	COG2814	Major facilitator Superfamily
LH59_RS18035	COG3530	Putative quorum-sensing-regulated virulence factor
LH59_RS18050	COG0625	glutathione transferase activity
LH59_RS18075	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS18085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH59_RS18145	COG1522	sequence-specific DNA binding
LH59_RS18170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS18180	COG0519	Catalyzes the synthesis of GMP from XMP
LH59_RS18185	COG0519	Catalyzes the synthesis of GMP from XMP
LH59_RS18210	COG0583	DNA-binding transcription factor activity
LH59_RS18220	COG2272	Belongs to the type-B carboxylesterase lipase family
LH59_RS18225	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS18230	COG1309	transcriptional regulator
LH59_RS18240	COG1473	amidohydrolase
LH59_RS18250	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
LH59_RS18270	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS18305	COG2011	ABC-type metal ion transport system permease component
LH59_RS18310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LH59_RS18315	COG1464	Belongs to the NlpA lipoprotein family
LH59_RS18325	COG2814	Major facilitator Superfamily
LH59_RS18335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LH59_RS18340	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_RS18380	COG2837	iron assimilation
LH59_RS18440	COG0583	DNA-binding transcription factor activity
LH59_RS18445	COG2814	Major facilitator Superfamily
LH59_RS18450	COG2169	Transcriptional regulator
LH59_RS18480	COG1272	protein, Hemolysin III
LH59_RS18490	COG1278	Cold shock
LH59_RS18520	COG4638	Rieske (2fe-2S)
LH59_RS18535	COG3321	synthase
LH59_RS18535	COG0604	alcohol dehydrogenase
LH59_RS18545	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS18550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_RS18575	COG0183	Belongs to the thiolase family
LH59_RS18590	COG0842	Transport permease protein
LH59_RS18595	COG1131	(ABC) transporter
LH59_RS18605	COG2197	response regulator
LH59_RS18610	COG1116	anion transmembrane transporter activity
LH59_RS18610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_RS18615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS18620	COG1116	anion transmembrane transporter activity
LH59_RS18625	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
LH59_RS18645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_RS18735	COG1396	sequence-specific DNA binding
LH59_RS18750	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS18785	COG1024	Enoyl-CoA hydratase
LH59_RS18800	COG0583	DNA-binding transcription factor activity
LH59_RS18860	COG3384	dioxygenase
LH59_RS18890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_RS18895	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LH59_RS18900	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
LH59_RS18910	COG1609	Transcriptional regulator
LH59_RS18915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_RS18920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_RS18930	COG1850	ribulose-bisphosphate carboxylase activity
LH59_RS18945	COG0505	Belongs to the CarA family
LH59_RS18970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LH59_RS18970	COG3608	succinylglutamate desuccinylase aspartoacylase
LH59_RS18975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LH59_RS18990	COG2207	Transcriptional regulator
LH59_RS18995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS19060	COG0668	transmembrane transport
LH59_RS19070	COG0166	Belongs to the GPI family
LH59_RS19095	COG0387	Pfam Sodium calcium exchanger
LH59_RS19100	COG3568	Endonuclease Exonuclease Phosphatase
LH59_RS19105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH59_RS19110	COG0392	lysyltransferase activity
LH59_RS19115	COG0297	glycogen (starch) synthase activity
LH59_RS19120	COG0366	Alpha amylase catalytic
LH59_RS19125	COG0366	Alpha amylase catalytic
LH59_RS19140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LH59_RS19145	COG1640	4-alpha-glucanotransferase
LH59_RS19170	COG1546	Belongs to the CinA family
LH59_RS19170	COG1058	Belongs to the CinA family
LH59_RS19175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH59_RS19185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH59_RS19195	COG0477	Major facilitator Superfamily
LH59_RS19215	COG1120	ATPase activity
LH59_RS19220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_RS19230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH59_RS19265	COG1414	Transcriptional regulator
LH59_RS19270	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH59_RS19275	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS19285	COG2721	sulfolactate sulfo-lyase activity
LH59_RS19295	COG0765	amino acid transport
LH59_RS19305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS19310	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_RS19320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH59_RS19325	COG3958	Transketolase
LH59_RS19330	COG3959	Transketolase, thiamine diphosphate binding domain
LH59_RS19335	COG1802	Transcriptional regulator
LH59_RS19340	COG0371	Dehydrogenase
LH59_RS19345	COG3246	L-lysine catabolic process to acetate
LH59_RS19350	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_RS19355	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS19365	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_RS19380	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS19380	COG0604	alcohol dehydrogenase
LH59_RS19380	COG3321	synthase
LH59_RS19385	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS19415	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS19420	COG0583	DNA-binding transcription factor activity
LH59_RS19425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LH59_RS19440	COG1538	Outer membrane efflux protein
LH59_RS19450	COG2814	Major facilitator Superfamily
LH59_RS19465	COG3384	dioxygenase
LH59_RS19480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LH59_RS19535	COG4964	Belongs to the GSP D family
LH59_RS19580	COG1846	Transcriptional regulator
LH59_RS19585	COG4172	Belongs to the ABC transporter superfamily
LH59_RS19590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS19595	COG0601	transmembrane transport
LH59_RS19610	COG0598	Magnesium transport protein CorA
LH59_RS19615	COG0210	DNA helicase
LH59_RS19630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH59_RS19645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LH59_RS19650	COG1045	serine acetyltransferase
LH59_RS19655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LH59_RS19660	COG0166	Belongs to the GPI family
LH59_RS19665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH59_RS19670	COG0489	protein tyrosine kinase activity
LH59_RS19670	COG3206	protein involved in exopolysaccharide biosynthesis
LH59_RS19675	COG1596	polysaccharide export
LH59_RS19685	COG1051	belongs to the nudix hydrolase family
LH59_RS19705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_RS19730	COG0463	Glycosyl transferase, family 2
LH59_RS19735	COG0110	maltose O-acetyltransferase activity
LH59_RS19740	COG0297	glycogen (starch) synthase activity
LH59_RS19745	COG2197	response regulator
LH59_RS19750	COG2197	response regulator
LH59_RS19760	COG1309	transcriptional regulator
LH59_RS19765	COG1960	acyl-CoA dehydrogenase activity
LH59_RS19775	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_RS19775	COG1024	Enoyl-CoA hydratase
LH59_RS19785	COG1024	Enoyl-CoA hydratase
LH59_RS19785	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_RS19790	COG0183	Belongs to the thiolase family
LH59_RS19805	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS19815	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS19825	COG1132	(ABC) transporter
LH59_RS19835	COG3395	kinase activity
LH59_RS19840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LH59_RS19850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LH59_RS19855	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LH59_RS19860	COG1024	Enoyl-CoA hydratase
LH59_RS19870	COG1414	Transcriptional regulator
LH59_RS19880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LH59_RS19900	COG0583	DNA-binding transcription factor activity
LH59_RS19920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LH59_RS19925	COG1309	transcriptional regulator
LH59_RS19935	COG1051	belongs to the nudix hydrolase family
LH59_RS19940	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LH59_RS19955	COG0784	Response regulator, receiver
LH59_RS19955	COG2205	protein histidine kinase activity
LH59_RS19965	COG0784	Response regulator, receiver
LH59_RS19965	COG2205	protein histidine kinase activity
LH59_RS19980	COG2863	cytochrome
LH59_RS19985	COG3258	Cytochrome c
LH59_RS19990	COG3278	Belongs to the heme-copper respiratory oxidase family
LH59_RS20015	COG0527	aspartate kinase activity
LH59_RS20020	COG0037	tRNA processing
LH59_RS20025	COG0825	malonyl-CoA metabolic process
LH59_RS20035	COG0215	cysteine-tRNA ligase activity
LH59_RS20050	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH59_RS20055	COG1968	undecaprenyl-diphosphatase activity
LH59_RS20060	COG1253	flavin adenine dinucleotide binding
LH59_RS20075	COG4263	nitrous-oxide reductase activity
LH59_RS20090	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
LH59_RS20100	COG1477	protein flavinylation
LH59_RS20105	COG4804	nuclease activity
LH59_RS20110	COG0483	inositol monophosphate 1-phosphatase activity
LH59_RS20130	COG0668	transmembrane transport
LH59_RS20170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_RS20175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS20180	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LH59_RS20215	COG3360	Dodecin
LH59_RS20225	COG0583	DNA-binding transcription factor activity
LH59_RS20230	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS20285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LH59_RS20290	COG2850	peptidyl-arginine hydroxylation
LH59_RS20300	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LH59_RS20305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_RS20310	COG1994	Peptidase M50
LH59_RS20315	COG0009	L-threonylcarbamoyladenylate synthase
LH59_RS20320	COG2321	neutral zinc metallopeptidase
LH59_RS20375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH59_RS20380	COG3969	phosphoadenosine phosphosulfate
LH59_RS20385	COG1475	DNA binding
LH59_RS20390	COG0642	Histidine kinase
LH59_RS20410	COG3188	usher protein
LH59_RS20415	COG3121	Chaperone
LH59_RS20450	COG3387	PFAM Glycoside hydrolase 15-related
LH59_RS20465	COG0840	transmembrane signaling receptor activity
LH59_RS20470	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS20475	COG1280	lysine exporter protein (LysE YggA)
LH59_RS20485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH59_RS20495	COG2207	Transcriptional regulator
LH59_RS20495	COG1917	Cupin 2, conserved barrel domain protein
LH59_RS20505	COG2084	Dehydrogenase
LH59_RS20525	COG1595	DNA-templated transcription, initiation
LH59_RS20540	COG1802	Transcriptional regulator
LH59_RS20555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH59_RS20580	COG2205	protein histidine kinase activity
LH59_RS20585	COG1764	response to oxidative stress
LH59_RS20590	COG0583	DNA-binding transcription factor activity
LH59_RS20595	COG0601	transmembrane transport
LH59_RS20600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS20605	COG0444	Belongs to the ABC transporter superfamily
LH59_RS20610	COG4608	Belongs to the ABC transporter superfamily
LH59_RS20625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_RS20630	COG0586	Pfam SNARE associated Golgi protein
LH59_RS20635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS20640	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LH59_RS20695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_RS20700	COG0765	amino acid transport
LH59_RS20710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS20720	COG1012	belongs to the aldehyde dehydrogenase family
LH59_RS20765	COG0348	domain, Protein
LH59_RS20785	COG3278	Belongs to the heme-copper respiratory oxidase family
LH59_RS20800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH59_RS20805	COG0156	8-amino-7-oxononanoate synthase activity
LH59_RS20815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LH59_RS20815	COG4106	trans-aconitate 2-methyltransferase activity
LH59_RS20820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LH59_RS20820	COG4106	trans-aconitate 2-methyltransferase activity
LH59_RS20835	COG2224	Isocitrate lyase
LH59_RS20840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH59_RS20840	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH59_RS20845	COG1858	cytochrome C peroxidase
LH59_RS20850	COG0583	DNA-binding transcription factor activity
LH59_RS20855	COG0473	3-isopropylmalate dehydrogenase activity
LH59_RS20865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LH59_RS20880	COG0736	holo-[acyl-carrier-protein] synthase activity
LH59_RS20885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LH59_RS20895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH59_RS20900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_RS20925	COG3842	ATPase activity
LH59_RS20930	COG4149	molybdate abc transporter
LH59_RS20935	COG0725	ABC transporter, periplasmic molybdate-binding protein
LH59_RS20940	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LH59_RS20960	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LH59_RS20970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH59_RS20980	COG4120	Belongs to the binding-protein-dependent transport system permease family
LH59_RS20990	COG0667	Aldo Keto reductase
LH59_RS21000	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS21005	COG1024	Enoyl-CoA hydratase
LH59_RS21015	COG1802	Transcriptional regulator
LH59_RS21025	COG0183	Belongs to the thiolase family
LH59_RS21030	COG1960	acyl-CoA dehydrogenase activity
LH59_RS21035	COG1960	acyl-CoA dehydrogenase activity
LH59_RS21040	COG0583	DNA-binding transcription factor activity
LH59_RS21065	COG4213	ABC transporter substrate-binding protein
LH59_RS21070	COG1129	ABC transporter
LH59_RS21075	COG4214	carbohydrate transport
LH59_RS21080	COG2706	6-phosphogluconolactonase activity
LH59_RS21085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_RS21100	COG3448	diguanylate cyclase activity
LH59_RS21100	COG4175	Glycine betaine
LH59_RS21105	COG4176	ABC-type proline glycine betaine transport system permease component
LH59_RS21115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LH59_RS21120	COG2814	Major facilitator Superfamily
LH59_RS21125	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LH59_RS21130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LH59_RS21165	COG1686	Belongs to the peptidase S11 family
LH59_RS21175	COG1846	Transcriptional regulator
LH59_RS21180	COG2814	Major facilitator Superfamily
LH59_RS21185	COG0495	leucyl-tRNA aminoacylation
LH59_RS21200	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LH59_RS21220	COG0154	amidase activity
LH59_RS21230	COG0477	Major facilitator Superfamily
LH59_RS21240	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_RS21255	COG0583	DNA-binding transcription factor activity
LH59_RS21305	COG0583	DNA-binding transcription factor activity
LH59_RS21310	COG0427	acetyl-CoA hydrolase
LH59_RS21315	COG0583	DNA-binding transcription factor activity
LH59_RS21320	COG3264	Mechanosensitive ion channel
LH59_RS21320	COG1511	domain protein
LH59_RS21370	COG3842	ATPase activity
LH59_RS21380	COG1177	transmembrane transport
LH59_RS21385	COG3938	Belongs to the proline racemase family
LH59_RS21400	COG0517	IMP dehydrogenase activity
LH59_RS21430	COG0500	methyltransferase
LH59_RS21445	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LH59_RS21460	COG0667	Aldo Keto reductase
LH59_RS21465	COG2207	Transcriptional regulator
LH59_RS21470	COG0583	DNA-binding transcription factor activity
LH59_RS21475	COG1335	isochorismatase
LH59_RS21485	COG2841	Protein conserved in bacteria
LH59_RS21500	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH59_RS21505	COG0438	transferase activity, transferring glycosyl groups
LH59_RS21540	COG2814	Major facilitator Superfamily
LH59_RS21545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH59_RS21570	COG0248	Ppx GppA phosphatase
LH59_RS21580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH59_RS21590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LH59_RS21595	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LH59_RS21600	COG1534	Rna-binding protein
LH59_RS21605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LH59_RS21610	COG0840	transmembrane signaling receptor activity
LH59_RS21615	COG2233	PERMEase
LH59_RS21635	COG3842	ATPase activity
LH59_RS21650	COG4221	oxidoreductase activity
LH59_RS21660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LH59_RS21665	COG0505	Belongs to the CarA family
LH59_RS21685	COG0745	RESPONSE REGULATOR receiver
LH59_RS21700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS21710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_RS21715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_RS21745	COG1074	ATP-dependent DNA helicase activity
LH59_RS21760	COG2070	2-Nitropropane dioxygenase
LH59_RS21795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH59_RS21800	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS21815	COG1686	Belongs to the peptidase S11 family
LH59_RS21830	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LH59_RS21835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LH59_RS21840	COG4974	Belongs to the 'phage' integrase family
LH59_RS21845	COG0583	DNA-binding transcription factor activity
LH59_RS21850	COG0028	Belongs to the TPP enzyme family
LH59_RS21895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LH59_RS21940	COG0028	Belongs to the TPP enzyme family
LH59_RS21945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS21960	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LH59_RS21965	COG1414	Transcriptional regulator
LH59_RS21970	COG0009	L-threonylcarbamoyladenylate synthase
LH59_RS21975	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LH59_RS21980	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LH59_RS21985	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LH59_RS21995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LH59_RS22015	COG1301	dicarboxylic acid transport
LH59_RS22025	COG3454	Phosphonate metabolism
LH59_RS22030	COG4778	phosphonate C-P lyase system protein PhnL
LH59_RS22035	COG4107	phosphonate C-P lyase system protein PhnK
LH59_RS22040	COG3627	carbon phosphorus lyase activity
LH59_RS22045	COG3626	phosphonate metabolism
LH59_RS22050	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LH59_RS22055	COG3624	Phosphonate C-P lyase system protein PhnG
LH59_RS22060	COG2188	Transcriptional regulator
LH59_RS22065	COG3454	Phosphonate metabolism
LH59_RS22070	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LH59_RS22075	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LH59_RS22080	COG0583	DNA-binding transcription factor activity
LH59_RS22085	COG0405	Gamma-glutamyltransferase
LH59_RS22100	COG3639	organic phosphonate transmembrane transporter activity
LH59_RS22105	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LH59_RS22110	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LH59_RS22120	COG0640	Transcriptional regulator
LH59_RS22130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LH59_RS22140	COG0739	heme binding
LH59_RS22150	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH59_RS22160	COG0306	phosphate transporter
LH59_RS22195	COG0625	glutathione transferase activity
LH59_RS22215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LH59_RS22220	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LH59_RS22235	COG0126	phosphoglycerate kinase activity
LH59_RS22240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LH59_RS22245	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LH59_RS22255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LH59_RS22260	COG2732	(Barnase) inhibitor
LH59_RS22270	COG0280	phosphate acetyltransferase
LH59_RS22270	COG0281	malic enzyme
LH59_RS22280	COG0436	Aminotransferase
LH59_RS22295	COG0741	lytic transglycosylase activity
LH59_RS22300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LH59_RS22315	COG4575	ribosome binding
LH59_RS22325	COG1116	anion transmembrane transporter activity
LH59_RS22330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH59_RS22335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH59_RS22340	COG1648	precorrin-2 dehydrogenase activity
LH59_RS22340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LH59_RS22345	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LH59_RS22350	COG2027	D-alanyl-D-alanine carboxypeptidase
LH59_RS22365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH59_RS22375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LH59_RS22380	COG0343	queuine tRNA-ribosyltransferase activity
LH59_RS22385	COG1862	Preprotein translocase
LH59_RS22390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH59_RS22395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH59_RS22415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LH59_RS22425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH59_RS22430	COG1702	phosphate starvation-inducible protein PhoH
LH59_RS22435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LH59_RS22440	COG4535	Mg2 and Co2 transporter CorC
LH59_RS22445	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LH59_RS22450	COG0667	Aldo Keto reductase
LH59_RS22495	COG0697	spore germination
LH59_RS22505	COG0678	peroxiredoxin activity
LH59_RS22515	COG0412	Dienelactone hydrolase
LH59_RS22525	COG0315	cyclic pyranopterin monophosphate synthase activity
LH59_RS22535	COG0314	molybdopterin synthase activity
LH59_RS22540	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH59_RS22545	COG0303	'Molybdopterin
LH59_RS22555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LH59_RS22575	COG3383	formate dehydrogenase (NAD+) activity
LH59_RS22580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LH59_RS22590	COG2223	nitrite transmembrane transporter activity
LH59_RS22615	COG0583	DNA-binding transcription factor activity
LH59_RS22620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LH59_RS22655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LH59_RS22670	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS22690	COG2828	Protein conserved in bacteria
LH59_RS22695	COG0583	DNA-binding transcription factor activity
LH59_RS22700	COG0456	acetyltransferase
LH59_RS22745	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_RS22770	COG4774	siderophore transport
LH59_RS22790	COG4585	Histidine kinase
LH59_RS22795	COG0671	phosphoesterase, PA-phosphatase related
LH59_RS22810	COG1666	GTP binding
LH59_RS22815	COG1120	ATPase activity
LH59_RS22820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH59_RS22825	COG4558	Periplasmic binding protein
LH59_RS22830	COG3720	iron ion transport
LH59_RS22840	COG3712	iron ion homeostasis
LH59_RS22845	COG1595	DNA-templated transcription, initiation
LH59_RS22860	COG2378	regulation of single-species biofilm formation
LH59_RS22890	COG1113	amino acid transport
LH59_RS22900	COG1522	sequence-specific DNA binding
LH59_RS22905	COG1272	protein, Hemolysin III
LH59_RS22910	COG3191	aminopeptidase activity
LH59_RS22915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS22920	COG0765	amino acid transport
LH59_RS22925	COG1126	abc transporter atp-binding protein
LH59_RS22930	COG4942	peptidase
LH59_RS22950	COG1999	signal sequence binding
LH59_RS22970	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LH59_RS22980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH59_RS22985	COG1845	cytochrome c oxidase, subunit III
LH59_RS22990	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LH59_RS23000	COG4772	TonB-dependent receptor
LH59_RS23020	COG0281	malic enzyme
LH59_RS23020	COG0280	phosphate acetyltransferase
LH59_RS23035	COG0697	spore germination
LH59_RS23065	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS23070	COG0583	DNA-binding transcription factor activity
LH59_RS23090	COG1396	sequence-specific DNA binding
LH59_RS23095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH59_RS23120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LH59_RS23135	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LH59_RS23140	COG1285	pathogenesis
LH59_RS23145	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS23150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH59_RS23165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LH59_RS23180	COG3712	iron ion homeostasis
LH59_RS23185	COG1595	DNA-templated transcription, initiation
LH59_RS23190	COG4773	Receptor
LH59_RS23210	COG5001	Diguanylate cyclase
LH59_RS23215	COG0330	HflC and HflK could
LH59_RS23240	COG2807	transmembrane transport
LH59_RS23245	COG2207	Transcriptional regulator
LH59_RS23250	COG4106	trans-aconitate 2-methyltransferase activity
LH59_RS23265	COG0583	DNA-binding transcription factor activity
LH59_RS23295	COG3712	iron ion homeostasis
LH59_RS23320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH59_RS23325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS23330	COG0477	Major facilitator Superfamily
LH59_RS23335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LH59_RS23340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH59_RS23345	COG1845	cytochrome c oxidase, subunit III
LH59_RS23350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LH59_RS23360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_RS23365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_RS23375	COG2814	Major facilitator Superfamily
LH59_RS23390	COG0625	glutathione transferase activity
LH59_RS23440	COG3707	response regulator
LH59_RS23445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH59_RS23445	COG2146	nitrite reductase [NAD(P)H] activity
LH59_RS23450	COG2146	nitrite reductase [NAD(P)H] activity
LH59_RS23450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH59_RS23460	COG0667	Aldo Keto reductase
LH59_RS23480	COG0583	DNA-binding transcription factor activity
LH59_RS23485	COG0023	Translation Initiation Factor
LH59_RS23495	COG0456	acetyltransferase
LH59_RS23495	COG0454	-acetyltransferase
LH59_RS23500	COG0583	DNA-binding transcription factor activity
LH59_RS23505	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_RS23520	COG0840	transmembrane signaling receptor activity
LH59_RS23525	COG2203	Gaf domain
LH59_RS23525	COG2199	diguanylate cyclase activity
LH59_RS23530	COG0640	Transcriptional regulator
LH59_RS23540	COG0740	serine-type endopeptidase activity
LH59_RS23545	COG2814	Major facilitator Superfamily
LH59_RS23575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_RS23585	COG0596	Alpha beta hydrolase
LH59_RS23595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH59_RS23605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH59_RS23610	COG0583	DNA-binding transcription factor activity
LH59_RS23645	COG0028	Belongs to the TPP enzyme family
LH59_RS23665	COG1230	cation diffusion facilitator family transporter
LH59_RS23685	COG1132	(ABC) transporter
LH59_RS23695	COG1201	RNA secondary structure unwinding
LH59_RS23700	COG1793	dna ligase
LH59_RS23705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LH59_RS23705	COG1793	dna ligase
LH59_RS23745	COG1960	acyl-CoA dehydrogenase activity
LH59_RS23755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_RS23760	COG0697	spore germination
LH59_RS23770	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS23780	COG0436	Aminotransferase
LH59_RS23785	COG0583	DNA-binding transcription factor activity
LH59_RS23790	COG0583	DNA-binding transcription factor activity
LH59_RS23815	COG0583	DNA-binding transcription factor activity
LH59_RS23820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_RS23825	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS23830	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_RS23845	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS23890	COG1595	DNA-templated transcription, initiation
LH59_RS23915	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LH59_RS23920	COG0459	protein refolding
LH59_RS23930	COG1846	Transcriptional regulator
LH59_RS23950	COG1917	Cupin 2, conserved barrel domain protein
LH59_RS23975	COG1137	ATPase activity
LH59_RS23985	COG0246	Mannitol dehydrogenase
LH59_RS23990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LH59_RS23995	COG1252	NADH dehydrogenase
LH59_RS24000	COG0284	orotidine-5'-phosphate decarboxylase activity
LH59_RS24005	COG1546	Belongs to the CinA family
LH59_RS24020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH59_RS24025	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LH59_RS24050	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LH59_RS24055	COG3639	organic phosphonate transmembrane transporter activity
LH59_RS24060	COG3639	organic phosphonate transmembrane transporter activity
LH59_RS24080	COG0742	ribosomal rna small subunit methyltransferase
LH59_RS24085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LH59_RS24090	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LH59_RS24095	COG3135	benzoate transporter
LH59_RS24110	COG2814	Major facilitator Superfamily
LH59_RS24125	COG0488	(ABC) transporter
LH59_RS24135	COG4804	nuclease activity
LH59_RS24140	COG0012	GTP binding
LH59_RS24150	COG0193	aminoacyl-tRNA hydrolase activity
LH59_RS24170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LH59_RS24175	COG0840	transmembrane signaling receptor activity
LH59_RS24190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH59_RS24215	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LH59_RS24225	COG0204	Acyl-transferase
LH59_RS24230	COG1368	sulfuric ester hydrolase activity
LH59_RS24235	COG2186	Transcriptional regulator
LH59_RS24240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_RS24250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LH59_RS24260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LH59_RS24260	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LH59_RS24275	COG0745	RESPONSE REGULATOR receiver
LH59_RS24280	COG0277	FAD linked oxidase domain protein
LH59_RS24295	COG0166	Belongs to the GPI family
LH59_RS24300	COG0405	Gamma-glutamyltransferase
LH59_RS24305	COG0438	transferase activity, transferring glycosyl groups
LH59_RS24310	COG0438	transferase activity, transferring glycosyl groups
LH59_RS24315	COG0438	transferase activity, transferring glycosyl groups
LH59_RS24340	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LH59_RS24345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH59_RS24375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS24380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH59_RS24395	COG0747	negative chemotaxis
LH59_RS24400	COG0601	transmembrane transport
LH59_RS24405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS24410	COG4172	Belongs to the ABC transporter superfamily
LH59_RS24415	COG0154	amidase activity
LH59_RS24430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH59_RS24430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH59_RS24435	COG0509	glycine decarboxylation via glycine cleavage system
LH59_RS24440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LH59_RS24455	COG2081	HI0933 family
LH59_RS24475	COG3706	GGDEF domain
LH59_RS24485	COG0717	Belongs to the dCTP deaminase family
LH59_RS24500	COG0489	protein tyrosine kinase activity
LH59_RS24510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH59_RS24510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH59_RS24515	COG1054	Belongs to the UPF0176 family
LH59_RS24530	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH59_RS24530	COG2755	lipolytic protein G-D-S-L family
LH59_RS24545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH59_RS24570	COG2200	EAL domain
LH59_RS24590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_RS24595	COG1129	ABC transporter
LH59_RS24595	COG0842	Transport permease protein
LH59_RS24600	COG0842	Transport permease protein
LH59_RS24610	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS24615	COG0583	DNA-binding transcription factor activity
LH59_RS24620	COG0697	spore germination
LH59_RS24625	COG1271	oxidase subunit
LH59_RS24630	COG1294	oxidase, subunit
LH59_RS24635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS24670	COG3258	Cytochrome c
LH59_RS24680	COG0625	glutathione transferase activity
LH59_RS24685	COG2986	histidine ammonia-lyase
LH59_RS24690	COG1234	tRNA 3'-trailer cleavage
LH59_RS24700	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LH59_RS24715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH59_RS24740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LH59_RS24755	COG2828	Protein conserved in bacteria
LH59_RS24760	COG1595	DNA-templated transcription, initiation
LH59_RS24765	COG3712	iron ion homeostasis
LH59_RS24775	COG0165	Argininosuccinate lyase
LH59_RS24780	COG2205	protein histidine kinase activity
LH59_RS24790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH59_RS24815	COG0625	glutathione transferase activity
LH59_RS24820	COG0477	Major facilitator Superfamily
LH59_RS24830	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS24835	COG3246	L-lysine catabolic process to acetate
LH59_RS24850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LH59_RS24855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH59_RS24860	COG0154	amidase activity
LH59_RS24865	COG0372	Belongs to the citrate synthase family
LH59_RS24870	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_RS24915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH59_RS24920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH59_RS24925	COG0583	DNA-binding transcription factor activity
LH59_RS24930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LH59_RS24955	COG1652	LysM domain
LH59_RS24960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LH59_RS24965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LH59_RS24980	COG0625	glutathione transferase activity
LH59_RS25005	COG1012	belongs to the aldehyde dehydrogenase family
LH59_RS25045	COG3550	peptidyl-serine autophosphorylation
LH59_RS25065	COG1414	Transcriptional regulator
LH59_RS25075	COG0800	Aldolase
LH59_RS25080	COG4948	Mandelate Racemase Muconate Lactonizing
LH59_RS25085	COG2271	Major facilitator Superfamily
LH59_RS25090	COG1131	(ABC) transporter
LH59_RS25105	COG4774	siderophore transport
LH59_RS25110	COG2814	Major facilitator Superfamily
LH59_RS25115	COG0326	Molecular chaperone. Has ATPase activity
LH59_RS25125	COG2233	PERMEase
LH59_RS25140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS25145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH59_RS25150	COG3246	L-lysine catabolic process to acetate
LH59_RS25160	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS25265	COG0784	Response regulator, receiver
LH59_RS25265	COG2198	Histidine kinase
LH59_RS25265	COG5002	protein histidine kinase activity
LH59_RS25285	COG0583	DNA-binding transcription factor activity
LH59_RS25295	COG1695	Transcriptional regulator
LH59_RS25310	COG0477	Major facilitator Superfamily
LH59_RS25325	COG0277	FAD linked oxidase domain protein
LH59_RS25335	COG3842	ATPase activity
LH59_RS25340	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH59_RS25360	COG0628	permease
LH59_RS25365	COG0583	DNA-binding transcription factor activity
LH59_RS25370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH59_RS25390	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
LH59_RS25400	COG2186	Transcriptional regulator
LH59_RS25410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH59_RS25435	COG0410	ABC transporter
LH59_RS25440	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS25445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LH59_RS25455	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH59_RS25460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH59_RS25465	COG0583	DNA-binding transcription factor activity
LH59_RS25470	COG0129	dihydroxy-acid dehydratase activity
LH59_RS25480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH59_RS25485	COG0583	DNA-binding transcription factor activity
LH59_RS25500	COG2200	EAL domain
LH59_RS25505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LH59_RS25510	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LH59_RS25515	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH59_RS25520	COG2031	fatty acid transporter
LH59_RS25530	COG1414	Transcriptional regulator
LH59_RS25540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LH59_RS25545	COG4829	muconolactone delta-isomerase
LH59_RS25555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH59_RS25575	COG0288	reversible hydration of carbon dioxide
LH59_RS25580	COG1802	Transcriptional regulator
LH59_RS25585	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS25595	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH59_RS25615	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS25625	COG1053	succinate dehydrogenase
LH59_RS25630	COG0625	glutathione transferase activity
LH59_RS25645	COG0583	DNA-binding transcription factor activity
LH59_RS25655	COG0583	DNA-binding transcription factor activity
LH59_RS25660	COG0477	Major facilitator Superfamily
LH59_RS25685	COG0318	PFAM AMP-dependent synthetase and ligase
LH59_RS25705	COG1464	Belongs to the NlpA lipoprotein family
LH59_RS25720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LH59_RS25725	COG2890	protein-(glutamine-N5) methyltransferase activity
LH59_RS25730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LH59_RS25745	COG1280	lysine exporter protein (LysE YggA)
LH59_RS25750	COG1522	sequence-specific DNA binding
LH59_RS25770	COG3622	Belongs to the hyi family
LH59_RS25790	COG0583	DNA-binding transcription factor activity
LH59_RS25795	COG2186	Transcriptional regulator
LH59_RS25800	COG3395	kinase activity
LH59_RS25805	COG2084	Dehydrogenase
LH59_RS25810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_RS25815	COG3622	Belongs to the hyi family
LH59_RS25820	COG0235	Class ii aldolase
LH59_RS25890	COG0142	geranyltranstransferase activity
LH59_RS25895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LH59_RS25900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LH59_RS25905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LH59_RS25910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LH59_RS25925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH59_RS25930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LH59_RS25940	COG2186	Transcriptional regulator
LH59_RS25945	COG3447	MASE1 domain protein
LH59_RS25945	COG5002	protein histidine kinase activity
LH59_RS25945	COG5001	Diguanylate cyclase
LH59_RS25950	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LH59_RS25955	COG0793	Belongs to the peptidase S41A family
LH59_RS25960	COG4942	peptidase
LH59_RS25965	COG0588	phosphoglycerate mutase activity
LH59_RS25975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH59_RS25980	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LH59_RS25985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LH59_RS25990	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS26000	COG1040	competence protein
LH59_RS26005	COG2226	methyltransferase
LH59_RS26010	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
LH59_RS26015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LH59_RS26020	COG0569	domain protein
LH59_RS26025	COG2204	response regulator
LH59_RS26030	COG5000	phosphorelay sensor kinase activity
LH59_RS26040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH59_RS26040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH59_RS26045	COG1280	lysine exporter protein (LysE YggA)
LH59_RS26050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH59_RS26060	COG1733	regulation of RNA biosynthetic process
LH59_RS26080	COG0546	phosphoglycolate phosphatase activity
LH59_RS26090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LH59_RS26095	COG0242	peptide deformylase activity
LH59_RS26100	COG0758	DNA mediated transformation
LH59_RS26115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH59_RS26120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS26125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LH59_RS26130	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS26145	COG1238	metal cluster binding
LH59_RS26150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LH59_RS26155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LH59_RS26170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LH59_RS26175	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LH59_RS26180	COG4988	ABC transporter
LH59_RS26190	COG1294	oxidase, subunit
LH59_RS26205	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LH59_RS26215	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LH59_RS26230	COG1137	ATPase activity
LH59_RS26235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LH59_RS26245	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LH59_RS26250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS26265	COG1660	Displays ATPase and GTPase activities
LH59_RS26275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH59_RS26285	COG0792	nuclease activity
LH59_RS26290	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LH59_RS26300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH59_RS26305	COG1464	Belongs to the NlpA lipoprotein family
LH59_RS26310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LH59_RS26320	COG1309	transcriptional regulator
LH59_RS26325	COG0471	metal ion transport
LH59_RS26330	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LH59_RS26335	COG0772	Belongs to the SEDS family
LH59_RS26340	COG0768	penicillin binding
LH59_RS26350	COG1792	Involved in formation and maintenance of cell shape
LH59_RS26355	COG1077	Cell shape determining protein MreB Mrl
LH59_RS26360	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH59_RS26365	COG0154	amidase activity
LH59_RS26370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH59_RS26380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LH59_RS26385	COG0708	Exodeoxyribonuclease III
LH59_RS26390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LH59_RS26400	COG0583	DNA-binding transcription factor activity
LH59_RS26410	COG0583	DNA-binding transcription factor activity
LH59_RS26435	COG1764	response to oxidative stress
LH59_RS26440	COG1846	Transcriptional regulator
LH59_RS26500	COG0640	Transcriptional regulator
LH59_RS26530	COG3189	MarR family transcriptional regulator
LH59_RS26550	COG1028	Short-chain dehydrogenase reductase Sdr
LH59_RS26555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LH59_RS26555	COG0352	thiamine-phosphate diphosphorylase activity
LH59_RS26555	COG0351	phosphomethylpyrimidine kinase
LH59_RS26565	COG0443	Heat shock 70 kDa protein
LH59_RS26575	COG3210	domain, Protein
LH59_RS26585	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LH59_RS26590	COG0513	Belongs to the DEAD box helicase family
LH59_RS26600	COG0617	tRNA 3'-terminal CCA addition
LH59_RS26610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LH59_RS26615	COG2308	Evidence 4 Homologs of previously reported genes of
LH59_RS26625	COG1305	Transglutaminase-like
LH59_RS26645	COG1950	PFAM Membrane protein of
LH59_RS26650	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LH59_RS26655	COG0438	transferase activity, transferring glycosyl groups
LH59_RS26670	COG0066	3-isopropylmalate dehydratase activity
LH59_RS26680	COG3181	Tripartite tricarboxylate transporter family receptor
LH59_RS26685	COG0583	DNA-binding transcription factor activity
LH59_RS26695	COG0477	Major facilitator Superfamily
LH59_RS26700	COG0154	amidase activity
LH59_RS26705	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LH59_RS26720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LH59_RS26730	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LH59_RS26735	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LH59_RS26745	COG0803	Belongs to the bacterial solute-binding protein 9 family
LH59_RS26760	COG0735	belongs to the Fur family
LH59_RS26765	COG0523	cobalamin synthesis protein
LH59_RS26775	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LH59_RS26780	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LH59_RS26790	COG2096	Adenosyltransferase
LH59_RS26795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LH59_RS26810	COG0321	lipoyl(octanoyl) transferase activity
LH59_RS26815	COG2921	Belongs to the UPF0250 family
LH59_RS26825	COG1686	Belongs to the peptidase S11 family
LH59_RS26850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LH59_RS26860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LH59_RS26870	COG0859	PFAM glycosyl transferase family 9
LH59_RS26895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH59_RS26930	COG0367	asparagine synthase
LH59_RS26945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH59_RS26955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH59_RS26965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH59_RS26980	COG0175	sulfate reduction
LH59_RS27010	COG2226	methyltransferase
LH59_RS27025	COG0367	asparagine synthase
LH59_RS27040	COG2814	Major facilitator Superfamily
LH59_RS27045	COG0697	spore germination
LH59_RS27070	COG3568	Endonuclease Exonuclease Phosphatase
LH59_RS27075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LH59_RS27100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH59_RS27115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH59_RS27120	COG1956	GAF domain-containing protein
LH59_RS27125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH59_RS27150	COG2186	Transcriptional regulator
LH59_RS27195	COG4106	trans-aconitate 2-methyltransferase activity
LH59_RS27205	COG2814	Major facilitator Superfamily
LH59_RS27215	COG0625	glutathione transferase activity
LH59_RS27220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LH59_RS27225	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LH59_RS27230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LH59_RS27240	COG1965	Belongs to the frataxin family
LH59_RS27245	COG0019	diaminopimelate decarboxylase activity
LH59_RS27250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LH59_RS27255	COG1333	cytochrome c biogenesis protein
LH59_RS27265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LH59_RS27280	COG4232	protein-disulfide reductase activity
LH59_RS27285	COG1324	tolerance protein
LH59_RS27295	COG0203	ribosomal protein L17
LH59_RS27300	COG0202	RNA polymerase activity
LH59_RS27305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LH59_RS27310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LH59_RS27315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LH59_RS27320	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LH59_RS27325	COG0201	protein transport
LH59_RS27330	COG0200	Binds to the 23S rRNA
LH59_RS27335	COG1841	ribosomal large subunit assembly
LH59_RS27340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LH59_RS27345	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LH59_RS27350	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LH59_RS27355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LH59_RS27360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LH59_RS27365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LH59_RS27370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LH59_RS27375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LH59_RS27390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH59_RS27390	COG2169	Transcriptional regulator
LH59_RS27405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH59_RS27425	COG4177	L-phenylalanine transmembrane transporter activity
LH59_RS27440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LH59_RS27445	COG0255	Belongs to the universal ribosomal protein uL29 family
LH59_RS27450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LH59_RS27455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LH59_RS27460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LH59_RS27465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LH59_RS27470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LH59_RS27475	COG0089	rRNA binding
LH59_RS27485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LH59_RS27490	COG0051	transcription antitermination factor activity, RNA binding
LH59_RS27500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LH59_RS27505	COG0049	tRNA binding
LH59_RS27510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LH59_RS27515	COG0745	RESPONSE REGULATOR receiver
LH59_RS27530	COG5002	protein histidine kinase activity
LH59_RS27545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LH59_RS27550	COG0085	RNA polymerase activity
LH59_RS27555	COG0222	ribosome binding
LH59_RS27560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LH59_RS27565	COG0081	regulation of translation
LH59_RS27570	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LH59_RS27580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH59_RS27590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LH59_RS27630	COG1840	ABC-type Fe3 transport system, periplasmic component
LH59_RS27635	COG3842	ATPase activity
LH59_RS27645	COG1349	DNA-binding transcription factor activity
LH59_RS27670	COG0583	DNA-binding transcription factor activity
LH59_RS27675	COG0252	asparaginase activity
LH59_RS27680	COG1475	DNA binding
LH59_RS27690	COG1192	Involved in chromosome partitioning
LH59_RS27695	COG0357	Ribosomal RNA small subunit methyltransferase G
LH59_RS27700	COG0445	tRNA wobble uridine modification
LH59_RS27705	COG1278	Cold shock
LH59_RS27710	COG3180	Ammonia monooxygenase
LH59_RS27715	COG0436	Aminotransferase
LH59_RS27745	COG0038	chloride channel
LH59_RS27760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LH59_RS27770	COG0601	transmembrane transport
LH59_RS27775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH59_RS27780	COG0444	Belongs to the ABC transporter superfamily
LH59_RS27785	COG4608	Belongs to the ABC transporter superfamily
LH59_RS27790	COG1473	amidohydrolase
LH59_RS27795	COG2175	clavaminate synthase activity
LH59_RS27805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LH59_RS27810	COG0753	catalase activity
LH59_RS27825	COG0594	ribonuclease P activity
LH59_RS27830	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LH59_RS27870	COG0457	Tetratricopeptide repeat
LH59_RS27880	COG0840	transmembrane signaling receptor activity
LH59_RS27910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA