locus-tag	class	description
I6I48_RS00015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I48_RS00020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I48_RS00045	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I48_RS00050	COG3639	organic phosphonate transmembrane transporter activity
I6I48_RS00055	COG3639	organic phosphonate transmembrane transporter activity
I6I48_RS00075	COG0742	ribosomal rna small subunit methyltransferase
I6I48_RS00080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I48_RS00085	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I48_RS00090	COG3135	benzoate transporter
I6I48_RS00105	COG2814	Major facilitator Superfamily
I6I48_RS00120	COG0488	(ABC) transporter
I6I48_RS00125	COG4773	Receptor
I6I48_RS00130	COG4804	nuclease activity
I6I48_RS00135	COG0012	GTP binding
I6I48_RS00145	COG0193	aminoacyl-tRNA hydrolase activity
I6I48_RS00165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I48_RS00185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I48_RS00210	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6I48_RS00220	COG0204	Acyl-transferase
I6I48_RS00225	COG1368	sulfuric ester hydrolase activity
I6I48_RS00230	COG2186	Transcriptional regulator
I6I48_RS00235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_RS00245	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_RS00255	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I48_RS00255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_RS00270	COG0745	RESPONSE REGULATOR receiver
I6I48_RS00275	COG0277	FAD linked oxidase domain protein
I6I48_RS00290	COG0166	Belongs to the GPI family
I6I48_RS00295	COG0405	Gamma-glutamyltransferase
I6I48_RS00300	COG0438	transferase activity, transferring glycosyl groups
I6I48_RS00305	COG0438	transferase activity, transferring glycosyl groups
I6I48_RS00310	COG0438	transferase activity, transferring glycosyl groups
I6I48_RS00335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I48_RS00340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I48_RS00370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS00375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I48_RS00390	COG0747	negative chemotaxis
I6I48_RS00395	COG0601	transmembrane transport
I6I48_RS00400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS00405	COG4172	Belongs to the ABC transporter superfamily
I6I48_RS00410	COG0154	amidase activity
I6I48_RS00425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I48_RS00425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I48_RS00430	COG0509	glycine decarboxylation via glycine cleavage system
I6I48_RS00435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I48_RS00450	COG2081	HI0933 family
I6I48_RS00470	COG3706	GGDEF domain
I6I48_RS00480	COG0717	Belongs to the dCTP deaminase family
I6I48_RS00495	COG0489	protein tyrosine kinase activity
I6I48_RS00505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I48_RS00505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I48_RS00510	COG1054	Belongs to the UPF0176 family
I6I48_RS00525	COG2755	lipolytic protein G-D-S-L family
I6I48_RS00525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I48_RS00540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I48_RS00565	COG2200	EAL domain
I6I48_RS00585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_RS00590	COG0842	Transport permease protein
I6I48_RS00590	COG1129	ABC transporter
I6I48_RS00595	COG0842	Transport permease protein
I6I48_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS00610	COG0583	DNA-binding transcription factor activity
I6I48_RS00615	COG0697	spore germination
I6I48_RS00625	COG1271	oxidase subunit
I6I48_RS00630	COG1294	oxidase, subunit
I6I48_RS00640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS00675	COG3258	Cytochrome c
I6I48_RS00685	COG0625	glutathione transferase activity
I6I48_RS00690	COG2986	histidine ammonia-lyase
I6I48_RS00695	COG1234	tRNA 3'-trailer cleavage
I6I48_RS00705	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I48_RS00720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I48_RS00750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I48_RS00765	COG2828	Protein conserved in bacteria
I6I48_RS00770	COG1595	DNA-templated transcription, initiation
I6I48_RS00775	COG3712	iron ion homeostasis
I6I48_RS00785	COG0165	Argininosuccinate lyase
I6I48_RS00790	COG2205	protein histidine kinase activity
I6I48_RS00800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I48_RS00830	COG0477	Major facilitator Superfamily
I6I48_RS00840	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS00845	COG3246	L-lysine catabolic process to acetate
I6I48_RS00860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I48_RS00865	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I48_RS00870	COG0154	amidase activity
I6I48_RS00875	COG0372	Belongs to the citrate synthase family
I6I48_RS00880	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_RS00905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I48_RS00910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_RS00915	COG0583	DNA-binding transcription factor activity
I6I48_RS00920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I48_RS00940	COG1652	LysM domain
I6I48_RS00945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I48_RS00950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I48_RS00965	COG0625	glutathione transferase activity
I6I48_RS00985	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_RS01030	COG1414	Transcriptional regulator
I6I48_RS01035	COG3734	2-keto-3-deoxy-galactonokinase
I6I48_RS01040	COG0800	Aldolase
I6I48_RS01045	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_RS01050	COG2271	Major facilitator Superfamily
I6I48_RS01055	COG1131	(ABC) transporter
I6I48_RS01070	COG4774	siderophore transport
I6I48_RS01075	COG2814	Major facilitator Superfamily
I6I48_RS01080	COG3550	peptidyl-serine autophosphorylation
I6I48_RS01085	COG1396	sequence-specific DNA binding
I6I48_RS01090	COG0326	Molecular chaperone. Has ATPase activity
I6I48_RS01100	COG2233	PERMEase
I6I48_RS01135	COG3451	type IV secretory pathway VirB4
I6I48_RS01145	COG3838	Conjugal transfer protein Trbc
I6I48_RS01150	COG4962	Type ii secretion system protein e
I6I48_RS01170	COG0583	DNA-binding transcription factor activity
I6I48_RS01185	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS01210	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS01215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_RS01220	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS01225	COG0183	Belongs to the thiolase family
I6I48_RS01230	COG1024	Enoyl-CoA hydratase
I6I48_RS01240	COG0625	glutathione transferase activity
I6I48_RS01285	COG4959	Type IV secretory pathway protease TraF
I6I48_RS01300	COG1192	Involved in chromosome partitioning
I6I48_RS01330	COG5489	Protein of unknown function (DUF736)
I6I48_RS01355	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS01380	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS01390	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS01395	COG0183	Belongs to the thiolase family
I6I48_RS01400	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS01440	COG4804	nuclease activity
I6I48_RS01480	COG2433	Pfam Transposase IS66
I6I48_RS01500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS01505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_RS01510	COG3246	L-lysine catabolic process to acetate
I6I48_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS01630	COG0784	Response regulator, receiver
I6I48_RS01630	COG2198	Histidine kinase
I6I48_RS01630	COG5002	protein histidine kinase activity
I6I48_RS01660	COG0583	DNA-binding transcription factor activity
I6I48_RS01670	COG1695	Transcriptional regulator
I6I48_RS01685	COG0477	Major facilitator Superfamily
I6I48_RS01700	COG0277	FAD linked oxidase domain protein
I6I48_RS01710	COG3842	ATPase activity
I6I48_RS01715	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I48_RS01735	COG0628	permease
I6I48_RS01740	COG0583	DNA-binding transcription factor activity
I6I48_RS01745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_RS01765	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I6I48_RS01775	COG2186	Transcriptional regulator
I6I48_RS01785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I48_RS01810	COG0410	ABC transporter
I6I48_RS01815	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS01820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I48_RS01830	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I48_RS01835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I48_RS01840	COG0583	DNA-binding transcription factor activity
I6I48_RS01845	COG0129	dihydroxy-acid dehydratase activity
I6I48_RS01855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I48_RS01860	COG0583	DNA-binding transcription factor activity
I6I48_RS01875	COG2200	EAL domain
I6I48_RS01880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I48_RS01885	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6I48_RS01890	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_RS01895	COG2031	fatty acid transporter
I6I48_RS01900	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS01905	COG1414	Transcriptional regulator
I6I48_RS01915	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I48_RS01920	COG4829	muconolactone delta-isomerase
I6I48_RS01930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I48_RS01950	COG0288	reversible hydration of carbon dioxide
I6I48_RS01955	COG1802	Transcriptional regulator
I6I48_RS01960	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS01970	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS01990	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS02000	COG1053	succinate dehydrogenase
I6I48_RS02005	COG0625	glutathione transferase activity
I6I48_RS02030	COG0583	DNA-binding transcription factor activity
I6I48_RS02035	COG0477	Major facilitator Superfamily
I6I48_RS02060	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS02080	COG1464	Belongs to the NlpA lipoprotein family
I6I48_RS02095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I48_RS02100	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I48_RS02105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I48_RS02120	COG1280	lysine exporter protein (LysE YggA)
I6I48_RS02125	COG1522	sequence-specific DNA binding
I6I48_RS02145	COG3622	Belongs to the hyi family
I6I48_RS02165	COG0583	DNA-binding transcription factor activity
I6I48_RS02170	COG2186	Transcriptional regulator
I6I48_RS02175	COG3395	kinase activity
I6I48_RS02180	COG2084	Dehydrogenase
I6I48_RS02185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_RS02190	COG3622	Belongs to the hyi family
I6I48_RS02195	COG0235	Class ii aldolase
I6I48_RS02265	COG0142	geranyltranstransferase activity
I6I48_RS02270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I48_RS02275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I48_RS02280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I48_RS02285	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I48_RS02300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I48_RS02305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I48_RS02315	COG2186	Transcriptional regulator
I6I48_RS02320	COG5002	protein histidine kinase activity
I6I48_RS02320	COG3447	MASE1 domain protein
I6I48_RS02320	COG5001	Diguanylate cyclase
I6I48_RS02325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I48_RS02330	COG0793	Belongs to the peptidase S41A family
I6I48_RS02335	COG4942	peptidase
I6I48_RS02340	COG0588	phosphoglycerate mutase activity
I6I48_RS02350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I48_RS02355	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6I48_RS02360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I48_RS02365	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS02375	COG1040	competence protein
I6I48_RS02380	COG2226	methyltransferase
I6I48_RS02385	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I48_RS02390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I48_RS02395	COG0569	domain protein
I6I48_RS02400	COG2204	response regulator
I6I48_RS02405	COG5000	phosphorelay sensor kinase activity
I6I48_RS02415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I48_RS02415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I48_RS02420	COG1280	lysine exporter protein (LysE YggA)
I6I48_RS02425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I48_RS02435	COG1733	regulation of RNA biosynthetic process
I6I48_RS02455	COG0546	phosphoglycolate phosphatase activity
I6I48_RS02465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I48_RS02470	COG0242	peptide deformylase activity
I6I48_RS02475	COG0758	DNA mediated transformation
I6I48_RS02490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS02495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS02500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I48_RS02505	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS02520	COG1238	metal cluster binding
I6I48_RS02525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I48_RS02530	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_RS02545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I48_RS02550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I48_RS02555	COG4988	ABC transporter
I6I48_RS02565	COG1294	oxidase, subunit
I6I48_RS02580	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6I48_RS02590	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6I48_RS02605	COG1137	ATPase activity
I6I48_RS02610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I48_RS02620	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6I48_RS02625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS02640	COG1660	Displays ATPase and GTPase activities
I6I48_RS02650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I48_RS02660	COG0792	nuclease activity
I6I48_RS02665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6I48_RS02675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_RS02680	COG1464	Belongs to the NlpA lipoprotein family
I6I48_RS02685	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I48_RS02695	COG1309	transcriptional regulator
I6I48_RS02700	COG0471	metal ion transport
I6I48_RS02705	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I48_RS02710	COG0772	Belongs to the SEDS family
I6I48_RS02715	COG0768	penicillin binding
I6I48_RS02725	COG1792	Involved in formation and maintenance of cell shape
I6I48_RS02730	COG1077	Cell shape determining protein MreB Mrl
I6I48_RS02735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I48_RS02740	COG0154	amidase activity
I6I48_RS02745	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I48_RS02760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I48_RS02765	COG0708	Exodeoxyribonuclease III
I6I48_RS02770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I48_RS02780	COG0583	DNA-binding transcription factor activity
I6I48_RS02790	COG0583	DNA-binding transcription factor activity
I6I48_RS02815	COG1764	response to oxidative stress
I6I48_RS02820	COG1846	Transcriptional regulator
I6I48_RS02880	COG0640	Transcriptional regulator
I6I48_RS02910	COG3189	MarR family transcriptional regulator
I6I48_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS02935	COG0352	thiamine-phosphate diphosphorylase activity
I6I48_RS02935	COG0351	phosphomethylpyrimidine kinase
I6I48_RS02935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I48_RS02975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I48_RS02980	COG0513	Belongs to the DEAD box helicase family
I6I48_RS02990	COG0617	tRNA 3'-terminal CCA addition
I6I48_RS03005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I48_RS03010	COG2308	Evidence 4 Homologs of previously reported genes of
I6I48_RS03020	COG1305	Transglutaminase-like
I6I48_RS03040	COG1950	PFAM Membrane protein of
I6I48_RS03045	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I48_RS03050	COG0438	transferase activity, transferring glycosyl groups
I6I48_RS03065	COG0066	3-isopropylmalate dehydratase activity
I6I48_RS03080	COG0583	DNA-binding transcription factor activity
I6I48_RS03085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I48_RS03120	COG0477	Major facilitator Superfamily
I6I48_RS03125	COG0154	amidase activity
I6I48_RS03130	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I48_RS03145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I48_RS03155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I48_RS03160	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I48_RS03170	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I48_RS03185	COG0735	belongs to the Fur family
I6I48_RS03190	COG0523	cobalamin synthesis protein
I6I48_RS03200	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I48_RS03205	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I48_RS03215	COG2096	Adenosyltransferase
I6I48_RS03240	COG1216	Glycosyl transferase, family 2
I6I48_RS03245	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I48_RS03325	COG0438	transferase activity, transferring glycosyl groups
I6I48_RS03335	COG1682	transport, permease protein
I6I48_RS03340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I48_RS03355	COG0321	lipoyl(octanoyl) transferase activity
I6I48_RS03360	COG2921	Belongs to the UPF0250 family
I6I48_RS03370	COG1686	Belongs to the peptidase S11 family
I6I48_RS03395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I48_RS03405	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6I48_RS03420	COG0859	PFAM glycosyl transferase family 9
I6I48_RS03425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I48_RS03435	COG2814	Major facilitator Superfamily
I6I48_RS03450	COG3568	Endonuclease Exonuclease Phosphatase
I6I48_RS03455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I48_RS03480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I48_RS03495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_RS03500	COG1956	GAF domain-containing protein
I6I48_RS03505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS03530	COG2186	Transcriptional regulator
I6I48_RS03565	COG4106	trans-aconitate 2-methyltransferase activity
I6I48_RS03575	COG2814	Major facilitator Superfamily
I6I48_RS03585	COG0625	glutathione transferase activity
I6I48_RS03590	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I48_RS03595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I48_RS03600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I48_RS03610	COG1965	Belongs to the frataxin family
I6I48_RS03620	COG0019	diaminopimelate decarboxylase activity
I6I48_RS03625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I48_RS03630	COG1333	cytochrome c biogenesis protein
I6I48_RS03640	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I48_RS03655	COG4232	protein-disulfide reductase activity
I6I48_RS03660	COG1324	tolerance protein
I6I48_RS03670	COG0203	ribosomal protein L17
I6I48_RS03675	COG0202	RNA polymerase activity
I6I48_RS03680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I48_RS03685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I48_RS03690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I48_RS03695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I48_RS03700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I48_RS03705	COG0201	protein transport
I6I48_RS03710	COG0200	Binds to the 23S rRNA
I6I48_RS03715	COG1841	ribosomal large subunit assembly
I6I48_RS03720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I48_RS03725	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I48_RS03730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I48_RS03735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I48_RS03740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I48_RS03745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I48_RS03750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I48_RS03755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I48_RS03770	COG2169	Transcriptional regulator
I6I48_RS03770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I48_RS03785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I48_RS03805	COG4177	L-phenylalanine transmembrane transporter activity
I6I48_RS03820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I48_RS03825	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I48_RS03830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I48_RS03835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I48_RS03840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I48_RS03845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I48_RS03850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I48_RS03855	COG0089	rRNA binding
I6I48_RS03865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I48_RS03870	COG0051	transcription antitermination factor activity, RNA binding
I6I48_RS03875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I48_RS03880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I48_RS03885	COG0049	tRNA binding
I6I48_RS03890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I48_RS03895	COG0745	RESPONSE REGULATOR receiver
I6I48_RS03910	COG5002	protein histidine kinase activity
I6I48_RS03925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I48_RS03930	COG0085	RNA polymerase activity
I6I48_RS03935	COG0222	ribosome binding
I6I48_RS03940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I48_RS03945	COG0081	regulation of translation
I6I48_RS03950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I48_RS03960	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I48_RS03970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I48_RS04010	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I48_RS04015	COG3842	ATPase activity
I6I48_RS04025	COG1349	DNA-binding transcription factor activity
I6I48_RS04050	COG0583	DNA-binding transcription factor activity
I6I48_RS04055	COG0252	asparaginase activity
I6I48_RS04060	COG1475	DNA binding
I6I48_RS04070	COG1192	Involved in chromosome partitioning
I6I48_RS04075	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I48_RS04080	COG0445	tRNA wobble uridine modification
I6I48_RS04085	COG1278	Cold shock
I6I48_RS04090	COG3180	Ammonia monooxygenase
I6I48_RS04095	COG0436	Aminotransferase
I6I48_RS04125	COG0038	chloride channel
I6I48_RS04135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I48_RS04145	COG0601	transmembrane transport
I6I48_RS04150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS04155	COG0444	Belongs to the ABC transporter superfamily
I6I48_RS04160	COG4608	Belongs to the ABC transporter superfamily
I6I48_RS04165	COG1473	amidohydrolase
I6I48_RS04170	COG2175	clavaminate synthase activity
I6I48_RS04180	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I48_RS04185	COG0753	catalase activity
I6I48_RS04195	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I48_RS04200	COG0594	ribonuclease P activity
I6I48_RS04205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I48_RS04210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I48_RS04215	COG0592	DNA-directed DNA polymerase activity
I6I48_RS04225	COG0583	DNA-binding transcription factor activity
I6I48_RS04250	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6I48_RS04260	COG0583	DNA-binding transcription factor activity
I6I48_RS04265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS04270	COG0765	amino acid transport
I6I48_RS04275	COG0765	amino acid transport
I6I48_RS04280	COG1126	abc transporter atp-binding protein
I6I48_RS04315	COG3842	ATPase activity
I6I48_RS04320	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I48_RS04325	COG1177	transmembrane transport
I6I48_RS04380	COG1609	Transcriptional regulator
I6I48_RS04390	COG3842	ATPase activity
I6I48_RS04395	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I48_RS04400	COG1177	transmembrane transport
I6I48_RS04425	COG0251	oxidation-reduction process
I6I48_RS04430	COG0402	S-adenosylhomocysteine deaminase activity
I6I48_RS04440	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS04445	COG3845	ABC transporter
I6I48_RS04450	COG1744	ABC transporter substrate-binding protein PnrA-like
I6I48_RS04460	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I48_RS04475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I48_RS04490	COG2814	Major facilitator Superfamily
I6I48_RS04505	COG3781	membrane
I6I48_RS04510	COG1522	sequence-specific DNA binding
I6I48_RS04515	COG0028	Belongs to the TPP enzyme family
I6I48_RS04520	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS04525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS04550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I48_RS04555	COG2922	Belongs to the Smg family
I6I48_RS04565	COG2358	TRAP transporter, solute receptor (TAXI family
I6I48_RS04585	COG0765	amino acid transport
I6I48_RS04590	COG0765	amino acid transport
I6I48_RS04595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS04600	COG3422	double-strand break repair
I6I48_RS04605	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS04610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I48_RS04625	COG1204	response to ionizing radiation
I6I48_RS04640	COG4977	sequence-specific DNA binding
I6I48_RS04645	COG2814	Major facilitator Superfamily
I6I48_RS04655	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6I48_RS04665	COG3339	Conserved Protein
I6I48_RS04695	COG2186	Transcriptional regulator
I6I48_RS04700	COG2814	Major facilitator Superfamily
I6I48_RS04715	COG1595	DNA-templated transcription, initiation
I6I48_RS04720	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS04735	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS04745	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS04785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I48_RS04790	COG0183	Belongs to the thiolase family
I6I48_RS04795	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6I48_RS04800	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS04805	COG1473	amidohydrolase
I6I48_RS04815	COG1742	UPF0060 membrane protein
I6I48_RS04830	COG1280	lysine exporter protein (LysE YggA)
I6I48_RS04855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I48_RS04865	COG0018	arginyl-trna synthetase
I6I48_RS04880	COG0395	ABC-type sugar transport system, permease component
I6I48_RS04885	COG1175	transmembrane transport
I6I48_RS04890	COG1653	transport
I6I48_RS04895	COG3842	ATPase activity
I6I48_RS04900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I48_RS04905	COG1609	Transcriptional regulator
I6I48_RS04915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I48_RS04930	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I48_RS04950	COG0583	DNA-binding transcription factor activity
I6I48_RS04970	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I48_RS04975	COG1280	lysine exporter protein (LysE YggA)
I6I48_RS04980	COG0513	Belongs to the DEAD box helicase family
I6I48_RS04985	COG5339	Protein conserved in bacteria
I6I48_RS04990	COG5339	Protein conserved in bacteria
I6I48_RS04995	COG1228	amidohydrolase
I6I48_RS05005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS05010	COG0601	transmembrane transport
I6I48_RS05015	COG0747	negative chemotaxis
I6I48_RS05020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I48_RS05030	COG2207	Transcriptional regulator
I6I48_RS05030	COG3708	Transcriptional regulator
I6I48_RS05050	COG0583	DNA-binding transcription factor activity
I6I48_RS05085	COG2969	positive regulation of protein catabolic process
I6I48_RS05090	COG0625	glutathione transferase activity
I6I48_RS05095	COG2857	Cytochrome c1
I6I48_RS05100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6I48_RS05105	COG0723	plastoquinol--plastocyanin reductase activity
I6I48_RS05110	COG1970	mechanosensitive ion channel activity
I6I48_RS05115	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I48_RS05120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I48_RS05135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I48_RS05140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I48_RS05145	COG0537	adenosine 5'-monophosphoramidase activity
I6I48_RS05150	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I48_RS05160	COG0107	imidazoleglycerol-phosphate synthase activity
I6I48_RS05165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I48_RS05170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I48_RS05175	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I48_RS05180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I48_RS05185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I48_RS05190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I48_RS05195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I48_RS05205	COG0842	Transport permease protein
I6I48_RS05210	COG1131	(ABC) transporter
I6I48_RS05220	COG2853	Lipoprotein
I6I48_RS05225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6I48_RS05230	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I48_RS05235	COG1127	ABC transporter
I6I48_RS05240	COG2070	2-Nitropropane dioxygenase
I6I48_RS05250	COG0477	Major facilitator Superfamily
I6I48_RS05265	COG0583	DNA-binding transcription factor activity
I6I48_RS05270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I48_RS05275	COG0511	ligase activity, forming carbon-carbon bonds
I6I48_RS05290	COG1984	allophanate hydrolase subunit 2
I6I48_RS05305	COG0070	glutamate synthase
I6I48_RS05305	COG0067	glutamate synthase
I6I48_RS05305	COG0069	glutamate synthase activity
I6I48_RS05330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I48_RS05350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I48_RS05380	COG1612	heme a metabolic process
I6I48_RS05390	COG1999	signal sequence binding
I6I48_RS05410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I48_RS05415	COG2814	Major facilitator Superfamily
I6I48_RS05425	COG0438	transferase activity, transferring glycosyl groups
I6I48_RS05445	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6I48_RS05455	COG2814	Major facilitator Superfamily
I6I48_RS05470	COG4774	siderophore transport
I6I48_RS05475	COG4592	Periplasmic binding protein
I6I48_RS05480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_RS05485	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_RS05490	COG1120	ATPase activity
I6I48_RS05495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_RS05510	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I48_RS05535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I48_RS05540	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I48_RS05545	COG2814	Major facilitator Superfamily
I6I48_RS05550	COG0583	DNA-binding transcription factor activity
I6I48_RS05560	COG2423	ornithine cyclodeaminase activity
I6I48_RS05565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I48_RS05570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I48_RS05580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I48_RS05590	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I48_RS05595	COG0463	Glycosyl transferase, family 2
I6I48_RS05645	COG0737	Belongs to the 5'-nucleotidase family
I6I48_RS05660	COG2188	Transcriptional regulator
I6I48_RS05670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I48_RS05675	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6I48_RS05690	COG0840	transmembrane signaling receptor activity
I6I48_RS05695	COG2814	Major facilitator Superfamily
I6I48_RS05710	COG3188	usher protein
I6I48_RS05770	COG1802	Transcriptional regulator
I6I48_RS05780	COG3069	C4-dicarboxylate transmembrane transporter activity
I6I48_RS05785	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_RS05810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS05820	COG0747	negative chemotaxis
I6I48_RS05845	COG1464	Belongs to the NlpA lipoprotein family
I6I48_RS05850	COG0431	NADPH-dependent FMN reductase
I6I48_RS05855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_RS05860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_RS05865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS05880	COG2011	ABC-type metal ion transport system permease component
I6I48_RS05885	COG1464	Belongs to the NlpA lipoprotein family
I6I48_RS05890	COG1116	anion transmembrane transporter activity
I6I48_RS05895	COG3585	molybdate ion transport
I6I48_RS05900	COG3064	Membrane
I6I48_RS05925	COG1607	acyl-coa hydrolase
I6I48_RS05940	COG0437	4 iron, 4 sulfur cluster binding
I6I48_RS05945	COG2864	formate dehydrogenase
I6I48_RS05960	COG3276	selenocysteine insertion sequence binding
I6I48_RS05970	COG1215	transferase activity, transferring glycosyl groups
I6I48_RS05975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_RS05980	COG1305	Transglutaminase-like
I6I48_RS05985	COG0709	Synthesizes selenophosphate from selenide and ATP
I6I48_RS06020	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_RS06025	COG3284	Transcriptional regulator
I6I48_RS06030	COG0134	indole-3-glycerol-phosphate synthase activity
I6I48_RS06035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I48_RS06040	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I48_RS06050	COG0546	phosphoglycolate phosphatase activity
I6I48_RS06055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I48_RS06060	COG2967	ApaG domain
I6I48_RS06070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I48_RS06075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I48_RS06085	COG0037	tRNA processing
I6I48_RS06100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I48_RS06115	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS06120	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS06135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I48_RS06160	COG3473	Maleate cis-trans isomerase
I6I48_RS06165	COG0583	DNA-binding transcription factor activity
I6I48_RS06180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I48_RS06190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I48_RS06195	COG1024	Enoyl-CoA hydratase
I6I48_RS06210	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I48_RS06225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I48_RS06230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I48_RS06235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I48_RS06245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I48_RS06255	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I48_RS06260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I48_RS06265	COG0210	DNA helicase
I6I48_RS06280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I48_RS06285	COG4221	oxidoreductase activity
I6I48_RS06295	COG2171	N-acyltransferase activity
I6I48_RS06305	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I48_RS06315	COG4608	Belongs to the ABC transporter superfamily
I6I48_RS06330	COG0601	transmembrane transport
I6I48_RS06340	COG2988	succinylglutamate desuccinylase activity
I6I48_RS06350	COG0583	DNA-binding transcription factor activity
I6I48_RS06355	COG0747	negative chemotaxis
I6I48_RS06365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I48_RS06370	COG1024	Enoyl-CoA hydratase
I6I48_RS06375	COG1024	Enoyl-CoA hydratase
I6I48_RS06385	COG1309	transcriptional regulator
I6I48_RS06400	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_RS06415	COG2814	Major facilitator Superfamily
I6I48_RS06430	COG1764	response to oxidative stress
I6I48_RS06435	COG0583	DNA-binding transcription factor activity
I6I48_RS06445	COG1595	DNA-templated transcription, initiation
I6I48_RS06450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I48_RS06455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_RS06470	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I48_RS06490	COG1129	ABC transporter
I6I48_RS06505	COG1802	Transcriptional regulator
I6I48_RS06515	COG0583	DNA-binding transcription factor activity
I6I48_RS06525	COG2988	succinylglutamate desuccinylase activity
I6I48_RS06535	COG2918	glutathione biosynthetic process
I6I48_RS06565	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I48_RS06570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I48_RS06580	COG2721	sulfolactate sulfo-lyase activity
I6I48_RS06585	COG2721	sulfolactate sulfo-lyase activity
I6I48_RS06590	COG2188	Transcriptional regulator
I6I48_RS06595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I48_RS06600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I48_RS06600	COG2813	Specifically methylates the guanine in position
I6I48_RS06605	COG2223	nitrite transmembrane transporter activity
I6I48_RS06615	COG2860	membrane
I6I48_RS06620	COG1802	Transcriptional regulator
I6I48_RS06630	COG1984	allophanate hydrolase subunit 2
I6I48_RS06635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I48_RS06645	COG0583	DNA-binding transcription factor activity
I6I48_RS06660	COG4774	siderophore transport
I6I48_RS06665	COG3712	iron ion homeostasis
I6I48_RS06675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I48_RS06690	COG2132	Multicopper oxidase
I6I48_RS06715	COG0745	RESPONSE REGULATOR receiver
I6I48_RS06720	COG2226	methyltransferase
I6I48_RS06735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I48_RS06745	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I48_RS06755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I48_RS06760	COG0351	phosphomethylpyrimidine kinase
I6I48_RS06765	COG2022	thiamine diphosphate biosynthetic process
I6I48_RS06770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I48_RS06775	COG4771	TonB-dependent receptor
I6I48_RS06785	COG2186	Transcriptional regulator
I6I48_RS06800	COG1063	alcohol dehydrogenase
I6I48_RS06810	COG0765	amino acid transport
I6I48_RS06815	COG1126	abc transporter atp-binding protein
I6I48_RS06820	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_RS06825	COG0246	Mannitol dehydrogenase
I6I48_RS06840	COG1194	a g-specific adenine glycosylase
I6I48_RS06860	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6I48_RS06865	COG2177	Part of the ABC transporter FtsEX involved in
I6I48_RS06870	COG2884	Cell division ATP-binding protein ftsE
I6I48_RS06875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS06880	COG4597	amino acid ABC transporter
I6I48_RS06885	COG0765	amino acid transport
I6I48_RS06890	COG1126	abc transporter atp-binding protein
I6I48_RS06915	COG1129	ABC transporter
I6I48_RS06920	COG4177	L-phenylalanine transmembrane transporter activity
I6I48_RS06935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I48_RS06940	COG2081	HI0933 family
I6I48_RS06950	COG1605	Chorismate mutase
I6I48_RS06950	COG0077	Prephenate dehydratase
I6I48_RS06985	COG0477	Major facilitator Superfamily
I6I48_RS06995	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I48_RS07000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I48_RS07020	COG0237	dephospho-CoA kinase activity
I6I48_RS07025	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6I48_RS07055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_RS07060	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I48_RS07075	COG3833	ABC-type maltose transport systems, permease component
I6I48_RS07080	COG1175	transmembrane transport
I6I48_RS07085	COG3842	ATPase activity
I6I48_RS07105	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I48_RS07140	COG0410	ABC transporter
I6I48_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS07180	COG1024	Enoyl-CoA hydratase
I6I48_RS07220	COG4638	Rieske (2fe-2S)
I6I48_RS07225	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I48_RS07230	COG1335	isochorismatase
I6I48_RS07235	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS07245	COG0741	lytic transglycosylase activity
I6I48_RS07250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I48_RS07255	COG0352	thiamine-phosphate diphosphorylase activity
I6I48_RS07270	COG1678	Uncharacterized ACR, COG1678
I6I48_RS07275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I48_RS07285	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I48_RS07300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I48_RS07305	COG0436	Aminotransferase
I6I48_RS07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS07320	COG0765	amino acid transport
I6I48_RS07325	COG1126	abc transporter atp-binding protein
I6I48_RS07330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I48_RS07340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I48_RS07345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I48_RS07355	COG3842	ATPase activity
I6I48_RS07360	COG1175	transmembrane transport
I6I48_RS07380	COG0557	exoribonuclease II activity
I6I48_RS07385	COG3150	esterase
I6I48_RS07390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I48_RS07395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_RS07400	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I48_RS07405	COG0511	ligase activity, forming carbon-carbon bonds
I6I48_RS07410	COG0439	Biotin carboxylase
I6I48_RS07415	COG2264	protein methyltransferase activity
I6I48_RS07425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I48_RS07425	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I48_RS07450	COG1696	Membrane protein involved in D-alanine export
I6I48_RS07460	COG0762	integral membrane protein
I6I48_RS07485	COG1522	sequence-specific DNA binding
I6I48_RS07490	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS07500	COG0583	DNA-binding transcription factor activity
I6I48_RS07515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I48_RS07520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I48_RS07520	COG1042	CoA-binding domain protein
I6I48_RS07520	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I48_RS07525	COG1335	isochorismatase
I6I48_RS07530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS07535	COG1116	anion transmembrane transporter activity
I6I48_RS07550	COG3028	Belongs to the UPF0307 family
I6I48_RS07555	COG0312	modulator of DNA gyrase
I6I48_RS07560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I48_RS07570	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS07575	COG4177	L-phenylalanine transmembrane transporter activity
I6I48_RS07590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I48_RS07595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I48_RS07600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I48_RS07610	COG0316	Belongs to the HesB IscA family
I6I48_RS07625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I48_RS07635	COG1280	lysine exporter protein (LysE YggA)
I6I48_RS07640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I48_RS07645	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I48_RS07660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I48_RS07660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I48_RS07675	COG2766	serine protein kinase
I6I48_RS07680	COG2718	Belongs to the UPF0229 family
I6I48_RS07685	COG2719	SpoVR family
I6I48_RS07725	COG2433	Pfam Transposase IS66
I6I48_RS07755	COG1196	nuclear chromosome segregation
I6I48_RS07805	COG0582	viral genome integration into host DNA
I6I48_RS07810	COG0583	DNA-binding transcription factor activity
I6I48_RS07815	COG1942	4-Oxalocrotonate Tautomerase
I6I48_RS07825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I48_RS07835	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS07880	COG4789	Type iii secretion
I6I48_RS07985	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I48_RS07990	COG4790	Type iii secretion
I6I48_RS07995	COG4794	Type iii secretion
I6I48_RS08000	COG4791	protein targeting
I6I48_RS08005	COG4792	protein secretion
I6I48_RS08035	COG2208	phosphoserine phosphatase activity
I6I48_RS08035	COG2770	Histidine kinase
I6I48_RS08045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I48_RS08050	COG2172	sigma factor antagonist activity
I6I48_RS08055	COG1366	Belongs to the anti-sigma-factor antagonist family
I6I48_RS08095	COG1388	LysM domain
I6I48_RS08095	COG0741	lytic transglycosylase activity
I6I48_RS08100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I48_RS08105	COG2226	methyltransferase
I6I48_RS08110	COG0328	RNA-DNA hybrid ribonuclease activity
I6I48_RS08120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_RS08125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I48_RS08140	COG1671	Belongs to the UPF0178 family
I6I48_RS08155	COG0786	glutamate:sodium symporter activity
I6I48_RS08165	COG0463	Glycosyl transferase, family 2
I6I48_RS08170	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I48_RS08185	COG0583	DNA-binding transcription factor activity
I6I48_RS08205	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS08225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_RS08235	COG0583	DNA-binding transcription factor activity
I6I48_RS08245	COG1346	cytolysis
I6I48_RS08255	COG0697	spore germination
I6I48_RS08260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS08275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I48_RS08285	COG1522	sequence-specific DNA binding
I6I48_RS08300	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I48_RS08305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_RS08320	COG0823	Involved in the tonB-independent uptake of proteins
I6I48_RS08330	COG0848	biopolymer transport protein
I6I48_RS08335	COG0811	peptide transport
I6I48_RS08340	COG0824	Thioesterase
I6I48_RS08345	COG0442	prolyl-tRNA aminoacylation
I6I48_RS08375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I48_RS08390	COG2084	Dehydrogenase
I6I48_RS08395	COG0405	Gamma-glutamyltransferase
I6I48_RS08435	COG0129	dihydroxy-acid dehydratase activity
I6I48_RS08440	COG4654	Cytochrome c, class I
I6I48_RS08445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I48_RS08455	COG1522	sequence-specific DNA binding
I6I48_RS08495	COG0583	DNA-binding transcription factor activity
I6I48_RS08505	COG1473	amidohydrolase
I6I48_RS08510	COG0418	dihydroorotase activity
I6I48_RS08515	COG0488	(ABC) transporter
I6I48_RS08525	COG2001	Belongs to the MraZ family
I6I48_RS08530	COG0275	rRNA processing
I6I48_RS08535	COG3116	cell division
I6I48_RS08545	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I48_RS08550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I48_RS08555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I48_RS08565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I48_RS08570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I48_RS08575	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I48_RS08580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I48_RS08590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I48_RS08595	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6I48_RS08605	COG0739	heme binding
I6I48_RS08610	COG0653	protein targeting
I6I48_RS08625	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS08630	COG0028	Belongs to the TPP enzyme family
I6I48_RS08640	COG0300	oxidoreductase activity
I6I48_RS08645	COG1522	sequence-specific DNA binding
I6I48_RS08660	COG2239	Acts as a magnesium transporter
I6I48_RS08670	COG2855	membrane
I6I48_RS08675	COG0583	DNA-binding transcription factor activity
I6I48_RS08680	COG1473	amidohydrolase
I6I48_RS08685	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS08690	COG0483	inositol monophosphate 1-phosphatase activity
I6I48_RS08695	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I48_RS08695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_RS08700	COG1501	Belongs to the glycosyl hydrolase 31 family
I6I48_RS08705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I48_RS08710	COG2011	ABC-type metal ion transport system permease component
I6I48_RS08725	COG1595	DNA-templated transcription, initiation
I6I48_RS08730	COG3712	iron ion homeostasis
I6I48_RS08750	COG0840	transmembrane signaling receptor activity
I6I48_RS08755	COG0583	DNA-binding transcription factor activity
I6I48_RS08765	COG0735	belongs to the Fur family
I6I48_RS08790	COG2818	Glycosylase
I6I48_RS08795	COG1368	sulfuric ester hydrolase activity
I6I48_RS08800	COG2982	Protein involved in outer membrane biogenesis
I6I48_RS08815	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS08830	COG2124	cytochrome p450
I6I48_RS08880	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6I48_RS08895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I48_RS08910	COG3178	'Phosphotransferase
I6I48_RS08920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_RS08925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I48_RS08930	COG1929	Belongs to the glycerate kinase type-1 family
I6I48_RS08935	COG0469	pyruvate kinase activity
I6I48_RS08940	COG0700	Nucleoside recognition
I6I48_RS08945	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS08950	COG0242	peptide deformylase activity
I6I48_RS08970	COG0204	Acyl-transferase
I6I48_RS08975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I48_RS08980	COG0751	glycine-tRNA ligase activity
I6I48_RS08985	COG0752	glycyl-tRNA synthetase alpha subunit
I6I48_RS08990	COG1024	Enoyl-CoA hydratase
I6I48_RS09005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_RS09010	COG2030	dehydratase
I6I48_RS09015	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS09035	COG2070	2-Nitropropane dioxygenase
I6I48_RS09045	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS09050	COG0183	Belongs to the thiolase family
I6I48_RS09060	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS09065	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS09070	COG1024	Enoyl-CoA hydratase
I6I48_RS09080	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6I48_RS09090	COG2301	Belongs to the HpcH HpaI aldolase family
I6I48_RS09095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I48_RS09105	COG0617	tRNA 3'-terminal CCA addition
I6I48_RS09120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I48_RS09130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I48_RS09135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I48_RS09140	COG0586	Pfam SNARE associated Golgi protein
I6I48_RS09150	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I48_RS09155	COG0802	atpase or kinase
I6I48_RS09160	COG0114	fumarate hydratase activity
I6I48_RS09170	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS09180	COG0405	Gamma-glutamyltransferase
I6I48_RS09185	COG0531	amino acid
I6I48_RS09190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_RS09195	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS09200	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS09205	COG0583	DNA-binding transcription factor activity
I6I48_RS09210	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I48_RS09230	COG2175	clavaminate synthase activity
I6I48_RS09240	COG0583	DNA-binding transcription factor activity
I6I48_RS09250	COG0579	oxidoreductase
I6I48_RS09260	COG0259	pyridoxamine-phosphate oxidase activity
I6I48_RS09275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_RS09280	COG1136	(ABC) transporter
I6I48_RS09280	COG0577	efflux transmembrane transporter activity
I6I48_RS09285	COG1538	Outer membrane efflux protein
I6I48_RS09290	COG0583	DNA-binding transcription factor activity
I6I48_RS09310	COG0577	efflux transmembrane transporter activity
I6I48_RS09310	COG1136	(ABC) transporter
I6I48_RS09345	COG1136	(ABC) transporter
I6I48_RS09345	COG0577	efflux transmembrane transporter activity
I6I48_RS09355	COG1566	PFAM secretion protein HlyD family protein
I6I48_RS09360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I48_RS09400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I48_RS09410	COG0800	Aldolase
I6I48_RS09425	COG0463	Glycosyl transferase, family 2
I6I48_RS09425	COG1216	Glycosyl transferase, family 2
I6I48_RS09450	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS09455	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6I48_RS09475	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I48_RS09480	COG4638	Rieske (2fe-2S)
I6I48_RS09505	COG0747	negative chemotaxis
I6I48_RS09510	COG0601	transmembrane transport
I6I48_RS09515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS09520	COG0444	Belongs to the ABC transporter superfamily
I6I48_RS09525	COG4608	Belongs to the ABC transporter superfamily
I6I48_RS09545	COG2746	aminoglycoside 3-N-acetyltransferase activity
I6I48_RS09550	COG0488	(ABC) transporter
I6I48_RS09575	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I48_RS09580	COG2894	cell division
I6I48_RS09585	COG0850	regulation of cytokinetic process
I6I48_RS09590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I48_RS09600	COG1294	oxidase, subunit
I6I48_RS09605	COG0514	ATP-dependent DNA helicase (RecQ)
I6I48_RS09620	COG4191	Histidine kinase
I6I48_RS09625	COG2255	four-way junction helicase activity
I6I48_RS09635	COG1090	epimerase
I6I48_RS09640	COG0632	four-way junction helicase activity
I6I48_RS09665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I48_RS09675	COG0006	proline dipeptidase activity
I6I48_RS09690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I48_RS09695	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_RS09710	COG4783	chaperone-mediated protein folding
I6I48_RS09750	COG2814	Major facilitator Superfamily
I6I48_RS09755	COG4771	TonB-dependent receptor
I6I48_RS09765	COG0513	Belongs to the DEAD box helicase family
I6I48_RS09780	COG1546	Belongs to the CinA family
I6I48_RS09780	COG1058	Belongs to the CinA family
I6I48_RS09785	COG1414	Transcriptional regulator
I6I48_RS09800	COG0167	dihydroorotate dehydrogenase activity
I6I48_RS09805	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6I48_RS09810	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I48_RS09930	COG0629	single-stranded DNA binding
I6I48_RS09935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I48_RS09950	COG0789	Transcriptional regulator
I6I48_RS09960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I48_RS09995	COG0789	Transcriptional regulator
I6I48_RS10145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I48_RS10150	COG1569	PIN domain
I6I48_RS10155	COG3311	Transcriptional regulator
I6I48_RS10210	COG2003	Belongs to the UPF0758 family
I6I48_RS10285	COG1695	Transcriptional regulator
I6I48_RS10295	COG0798	PFAM Bile acid sodium symporter
I6I48_RS10310	COG0640	Transcriptional regulator
I6I48_RS10315	COG5002	protein histidine kinase activity
I6I48_RS10320	COG0745	RESPONSE REGULATOR receiver
I6I48_RS10325	COG2132	Multicopper oxidase
I6I48_RS10365	COG0583	DNA-binding transcription factor activity
I6I48_RS10370	COG1396	sequence-specific DNA binding
I6I48_RS10400	COG0582	viral genome integration into host DNA
I6I48_RS10425	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I48_RS10430	COG0735	belongs to the Fur family
I6I48_RS10435	COG0497	DNA recombination
I6I48_RS10445	COG1420	regulation of RNA biosynthetic process
I6I48_RS10450	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I48_RS10460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I48_RS10470	COG0443	Heat shock 70 kDa protein
I6I48_RS10475	COG0484	heat shock protein binding
I6I48_RS10485	COG0612	Peptidase, M16
I6I48_RS10510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I48_RS10545	COG0840	transmembrane signaling receptor activity
I6I48_RS10550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_RS10565	COG0745	RESPONSE REGULATOR receiver
I6I48_RS10570	COG2205	protein histidine kinase activity
I6I48_RS10575	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I48_RS10580	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I48_RS10585	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I48_RS10600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I48_RS10610	COG1193	negative regulation of DNA recombination
I6I48_RS10615	COG0492	ferredoxin-NADP+ reductase activity
I6I48_RS10620	COG1674	ftsk spoiiie
I6I48_RS10625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I48_RS10630	COG0251	oxidation-reduction process
I6I48_RS10635	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I48_RS10640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6I48_RS10640	COG0517	IMP dehydrogenase activity
I6I48_RS10660	COG0601	transmembrane transport
I6I48_RS10675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I48_RS10680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I48_RS10685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I48_RS10730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_RS10740	COG4774	siderophore transport
I6I48_RS10745	COG4607	ABC-type enterochelin transport system periplasmic component
I6I48_RS10750	COG4604	ABC transporter, ATP-binding protein
I6I48_RS10755	COG4605	iron ion homeostasis
I6I48_RS10760	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_RS10765	COG1132	(ABC) transporter
I6I48_RS10770	COG1132	(ABC) transporter
I6I48_RS10770	COG2375	cellular response to nickel ion
I6I48_RS10790	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS10795	COG3022	response to hydroperoxide
I6I48_RS10800	COG1289	transmembrane transporter activity
I6I48_RS10805	COG0028	Belongs to the TPP enzyme family
I6I48_RS10810	COG0440	acetolactate synthase activity
I6I48_RS10815	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I48_RS10820	COG1183	phosphatidylcholine synthase activity
I6I48_RS10830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I48_RS10835	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I48_RS10845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I48_RS10865	COG2207	Transcriptional regulator
I6I48_RS10890	COG0149	triose-phosphate isomerase activity
I6I48_RS10895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I48_RS10920	COG0840	transmembrane signaling receptor activity
I6I48_RS10940	COG1910	domain protein
I6I48_RS10960	COG1595	DNA-templated transcription, initiation
I6I48_RS10965	COG3712	iron ion homeostasis
I6I48_RS10990	COG0642	Histidine kinase
I6I48_RS11000	COG2851	Citrate transporter
I6I48_RS11005	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS11025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I48_RS11030	COG0784	Response regulator, receiver
I6I48_RS11030	COG4191	Histidine kinase
I6I48_RS11045	COG3604	Transcriptional regulator
I6I48_RS11050	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6I48_RS11055	COG3813	Protein conserved in bacteria
I6I48_RS11060	COG2354	Protein conserved in bacteria
I6I48_RS11065	COG4772	TonB-dependent receptor
I6I48_RS11070	COG1522	sequence-specific DNA binding
I6I48_RS11090	COG4172	Belongs to the ABC transporter superfamily
I6I48_RS11100	COG0747	negative chemotaxis
I6I48_RS11120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_RS11125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_RS11135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I48_RS11140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_RS11145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_RS11165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_RS11175	COG1309	transcriptional regulator
I6I48_RS11180	COG0583	DNA-binding transcription factor activity
I6I48_RS11200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I48_RS11225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_RS11230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I48_RS11235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I48_RS11240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I48_RS11245	COG0649	NAD binding
I6I48_RS11250	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6I48_RS11260	COG1034	ATP synthesis coupled electron transport
I6I48_RS11265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I48_RS11270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I48_RS11280	COG0713	ATP synthesis coupled electron transport
I6I48_RS11295	COG1007	ATP synthesis coupled electron transport
I6I48_RS11310	COG4774	siderophore transport
I6I48_RS11315	COG0560	Phosphoserine phosphatase
I6I48_RS11320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I48_RS11325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I48_RS11330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I48_RS11340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I48_RS11345	COG0450	alkyl hydroperoxide reductase
I6I48_RS11360	COG1214	PFAM Peptidase M22, glycoprotease
I6I48_RS11365	COG1573	uracil-dna glycosylase
I6I48_RS11370	COG0477	Major facilitator Superfamily
I6I48_RS11375	COG1196	nuclear chromosome segregation
I6I48_RS11385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I48_RS11390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_RS11400	COG2917	probably involved in intracellular septation
I6I48_RS11405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I48_RS11410	COG1122	ATPase activity
I6I48_RS11415	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I48_RS11420	COG1268	BioY protein
I6I48_RS11455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I48_RS11490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I48_RS11495	COG2878	Part of a membrane complex involved in electron transport
I6I48_RS11510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I48_RS11515	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I48_RS11520	COG0251	oxidation-reduction process
I6I48_RS11530	COG3228	Belongs to the MtfA family
I6I48_RS11535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I48_RS11545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I48_RS11555	COG0159	tryptophan synthase activity
I6I48_RS11560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I48_RS11565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6I48_RS11570	COG1530	ribonuclease E activity
I6I48_RS11575	COG0564	pseudouridine synthase activity
I6I48_RS11580	COG0546	phosphoglycolate phosphatase activity
I6I48_RS11585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I48_RS11590	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I48_RS11605	COG0424	maF-like protein
I6I48_RS11610	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I48_RS11615	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I48_RS11625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I48_RS11630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I48_RS11640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I48_RS11645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I48_RS11670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I48_RS11675	COG0481	GTPase activity
I6I48_RS11680	COG0681	Belongs to the peptidase S26 family
I6I48_RS11685	COG0571	ribonuclease III activity
I6I48_RS11690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I48_RS11695	COG1381	Involved in DNA repair and RecF pathway recombination
I6I48_RS11745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I48_RS11770	COG0583	DNA-binding transcription factor activity
I6I48_RS11780	COG0791	NLP P60 protein
I6I48_RS11790	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6I48_RS11800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I48_RS11805	COG0697	spore germination
I6I48_RS11810	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6I48_RS11815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I48_RS11835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_RS11860	COG2153	protein acetylation
I6I48_RS11870	COG1446	asparaginase
I6I48_RS11875	COG4172	Belongs to the ABC transporter superfamily
I6I48_RS11880	COG0747	negative chemotaxis
I6I48_RS11915	COG0504	CTP synthase activity
I6I48_RS11925	COG0148	phosphopyruvate hydratase activity
I6I48_RS11940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I48_RS11950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I48_RS11995	COG3846	protein secretion by the type IV secretion system
I6I48_RS12010	COG3451	type IV secretory pathway VirB4
I6I48_RS12020	COG3838	Conjugal transfer protein Trbc
I6I48_RS12025	COG4962	Type ii secretion system protein e
I6I48_RS12045	COG0583	DNA-binding transcription factor activity
I6I48_RS12100	COG4959	Type IV secretory pathway protease TraF
I6I48_RS12115	COG1192	Involved in chromosome partitioning
I6I48_RS12155	COG5489	Protein of unknown function (DUF736)
I6I48_RS12190	COG2003	Belongs to the UPF0758 family
I6I48_RS12255	COG1981	membrane
I6I48_RS12275	COG0039	L-malate dehydrogenase activity
I6I48_RS12280	COG2188	Transcriptional regulator
I6I48_RS12285	COG2009	succinate dehydrogenase
I6I48_RS12290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6I48_RS12295	COG1053	succinate dehydrogenase
I6I48_RS12300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I48_RS12305	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6I48_RS12310	COG0372	Belongs to the citrate synthase family
I6I48_RS12325	COG0281	malic enzyme
I6I48_RS12325	COG0280	phosphate acetyltransferase
I6I48_RS12335	COG1297	OPT oligopeptide transporter protein
I6I48_RS12340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I48_RS12355	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I48_RS12360	COG1522	sequence-specific DNA binding
I6I48_RS12365	COG0567	Dehydrogenase, E1 component
I6I48_RS12370	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I48_RS12375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I48_RS12380	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I48_RS12385	COG1595	DNA-templated transcription, initiation
I6I48_RS12390	COG3712	iron ion homeostasis
I6I48_RS12395	COG4774	siderophore transport
I6I48_RS12430	COG2183	response to ionizing radiation
I6I48_RS12435	COG1199	ATP-dependent helicase activity
I6I48_RS12445	COG0564	pseudouridine synthase activity
I6I48_RS12450	COG1496	oxidoreductase activity
I6I48_RS12455	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6I48_RS12460	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS12465	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
I6I48_RS12490	COG2831	hemolysin activation secretion protein
I6I48_RS12495	COG3210	domain, Protein
I6I48_RS12510	COG2823	Periplasmic or secreted lipoprotein
I6I48_RS12520	COG3237	CsbD-like
I6I48_RS12525	COG0189	ligase activity
I6I48_RS12525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I48_RS12530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I48_RS12530	COG0189	ligase activity
I6I48_RS12535	COG1132	(ABC) transporter
I6I48_RS12550	COG2833	Protein of unknown function (DUF455)
I6I48_RS12555	COG2258	MOSC domain
I6I48_RS12560	COG2951	lytic endotransglycosylase activity
I6I48_RS12575	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS12585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I48_RS12595	COG1696	Membrane protein involved in D-alanine export
I6I48_RS12615	COG1215	transferase activity, transferring glycosyl groups
I6I48_RS12625	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I48_RS12780	COG0616	signal peptide processing
I6I48_RS12980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I48_RS12995	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6I48_RS13005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I48_RS13015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I48_RS13020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I48_RS13040	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6I48_RS13045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6I48_RS13050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_RS13080	COG2951	lytic endotransglycosylase activity
I6I48_RS13085	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6I48_RS13110	COG2985	domain, Protein
I6I48_RS13115	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS13120	COG0450	alkyl hydroperoxide reductase
I6I48_RS13130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I48_RS13135	COG4208	sulfate ABC transporter
I6I48_RS13145	COG0175	sulfate reduction
I6I48_RS13175	COG0335	large ribosomal subunit rRNA binding
I6I48_RS13185	COG1162	GTPase activity
I6I48_RS13190	COG0501	Belongs to the peptidase M48B family
I6I48_RS13195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I48_RS13200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I48_RS13205	COG3327	negative regulation of DNA-templated transcription, initiation
I6I48_RS13210	COG3396	Phenylacetate-CoA oxygenase
I6I48_RS13215	COG3460	Phenylacetate-CoA oxygenase
I6I48_RS13220	COG3396	Phenylacetate-CoA oxygenase
I6I48_RS13225	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I48_RS13230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I48_RS13235	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_RS13240	COG1024	Enoyl-CoA hydratase
I6I48_RS13245	COG2050	protein possibly involved in aromatic compounds catabolism
I6I48_RS13255	COG0534	Mate efflux family protein
I6I48_RS13270	COG3483	tryptophan 2,3-dioxygenase activity
I6I48_RS13275	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6I48_RS13280	COG2003	Belongs to the UPF0758 family
I6I48_RS13290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I48_RS13295	COG0625	glutathione transferase activity
I6I48_RS13300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I48_RS13325	COG0523	cobalamin synthesis protein
I6I48_RS13330	COG0523	cobalamin synthesis protein
I6I48_RS13335	COG0583	DNA-binding transcription factor activity
I6I48_RS13350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I48_RS13355	COG1187	pseudouridine synthase activity
I6I48_RS13360	COG0779	Required for maturation of 30S ribosomal subunits
I6I48_RS13365	COG0195	Participates in both transcription termination and antitermination
I6I48_RS13365	COG2251	uridine kinase activity
I6I48_RS13370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I48_RS13375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I48_RS13380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I48_RS13385	COG1217	gtp-binding protein TYPA
I6I48_RS13405	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS13410	COG1473	amidohydrolase
I6I48_RS13415	COG1611	Belongs to the LOG family
I6I48_RS13430	COG0412	Dienelactone hydrolase
I6I48_RS13440	COG1760	l-serine dehydratase
I6I48_RS13445	COG0501	Belongs to the peptidase M48B family
I6I48_RS13465	COG0583	DNA-binding transcription factor activity
I6I48_RS13470	COG3842	ATPase activity
I6I48_RS13480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I48_RS13485	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I48_RS13505	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS13515	COG1722	exodeoxyribonuclease VII activity
I6I48_RS13520	COG0142	geranyltranstransferase activity
I6I48_RS13530	COG1469	GTP cyclohydrolase I activity
I6I48_RS13535	COG3739	integral membrane protein
I6I48_RS13540	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I48_RS13545	COG2965	DNA replication, synthesis of RNA primer
I6I48_RS13550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I48_RS13555	COG0359	binds to the 23S rRNA
I6I48_RS13565	COG0305	Participates in initiation and elongation during chromosome replication
I6I48_RS13575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I48_RS13610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS13660	COG0540	Belongs to the ATCase OTCase family
I6I48_RS13695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I48_RS13700	COG2137	regulation of response to DNA damage stimulus
I6I48_RS13725	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I48_RS13730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I48_RS13735	COG0861	Integral membrane protein TerC family
I6I48_RS13740	COG0861	Integral membrane protein TerC family
I6I48_RS13745	COG0181	hydroxymethylbilane synthase activity
I6I48_RS13765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I48_RS13775	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS13805	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS13825	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6I48_RS13830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I48_RS13840	COG0436	Aminotransferase
I6I48_RS13860	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6I48_RS13865	COG0308	aminopeptidase N
I6I48_RS13880	COG0312	modulator of DNA gyrase
I6I48_RS13885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I48_RS13890	COG0277	FAD linked oxidase domain protein
I6I48_RS13895	COG0277	FAD linked oxidase domain protein
I6I48_RS13900	COG0277	FAD linked oxidase domain protein
I6I48_RS13905	COG0247	lactate metabolic process
I6I48_RS13935	COG0583	DNA-binding transcription factor activity
I6I48_RS13940	COG0482	sulfurtransferase activity
I6I48_RS13945	COG0730	response to heat
I6I48_RS13950	COG0625	glutathione transferase activity
I6I48_RS13960	COG3909	cytochrome
I6I48_RS13990	COG0628	permease
I6I48_RS14000	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6I48_RS14115	COG0697	spore germination
I6I48_RS14190	COG0419	ATPase involved in DNA repair
I6I48_RS14195	COG2974	May be involved in recombination
I6I48_RS14485	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6I48_RS14495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I48_RS14500	COG0069	glutamate synthase activity
I6I48_RS14505	COG2391	methyltransferase activity
I6I48_RS14510	COG0679	Auxin Efflux Carrier
I6I48_RS14540	COG0557	exoribonuclease II activity
I6I48_RS14545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I48_RS14555	COG3128	pkhd-type hydroxylase
I6I48_RS14560	COG0776	regulation of translation
I6I48_RS14590	COG0642	Histidine kinase
I6I48_RS14595	COG3158	transport of potassium into the cell
I6I48_RS14600	COG0137	argininosuccinate synthase activity
I6I48_RS14605	COG0583	DNA-binding transcription factor activity
I6I48_RS14610	COG3618	amidohydrolase
I6I48_RS14630	COG0596	Alpha beta hydrolase
I6I48_RS14630	COG2945	thiolester hydrolase activity
I6I48_RS14635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I48_RS14640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I48_RS14650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I48_RS14650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_RS14660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_RS14665	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6I48_RS14675	COG3642	lipopolysaccharide core region biosynthetic process
I6I48_RS14685	COG3842	ATPase activity
I6I48_RS14690	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I48_RS14695	COG1177	transmembrane transport
I6I48_RS14715	COG1322	Protein conserved in bacteria
I6I48_RS14725	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS14735	COG0704	Plays a role in the regulation of phosphate uptake
I6I48_RS14745	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6I48_RS14750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I48_RS14750	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I48_RS14755	COG1643	Atp-dependent helicase
I6I48_RS14760	COG0395	ABC-type sugar transport system, permease component
I6I48_RS14765	COG1116	anion transmembrane transporter activity
I6I48_RS14780	COG0438	transferase activity, transferring glycosyl groups
I6I48_RS14785	COG0726	polysaccharide deacetylase
I6I48_RS14800	COG0726	polysaccharide deacetylase
I6I48_RS14825	COG1132	(ABC) transporter
I6I48_RS14830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I48_RS14830	COG0475	glutathione-regulated potassium exporter activity
I6I48_RS14840	COG5001	Diguanylate cyclase
I6I48_RS14840	COG4251	negative regulation of phosphorylation
I6I48_RS14840	COG3706	GGDEF domain
I6I48_RS14840	COG2203	Gaf domain
I6I48_RS15085	COG4386	tail sheath protein
I6I48_RS15100	COG0739	heme binding
I6I48_RS15100	COG1196	nuclear chromosome segregation
I6I48_RS15100	COG0741	lytic transglycosylase activity
I6I48_RS15180	COG1530	ribonuclease E activity
I6I48_RS15210	COG2204	response regulator
I6I48_RS15215	COG4191	Histidine kinase
I6I48_RS15220	COG1301	dicarboxylic acid transport
I6I48_RS15230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I48_RS15235	COG0799	negative regulation of ribosome biogenesis
I6I48_RS15240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I48_RS15250	COG0151	Belongs to the GarS family
I6I48_RS15255	COG0217	transcriptional regulatory protein
I6I48_RS15260	COG0433	COG0433 Predicted ATPase
I6I48_RS15265	COG0473	3-isopropylmalate dehydrogenase activity
I6I48_RS15275	COG2814	Major facilitator Superfamily
I6I48_RS15280	COG1566	PFAM secretion protein HlyD family protein
I6I48_RS15290	COG1846	Transcriptional regulator
I6I48_RS15320	COG3391	amine dehydrogenase activity
I6I48_RS15330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I48_RS15350	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I48_RS15355	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I48_RS15365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I48_RS15390	COG1309	transcriptional regulator
I6I48_RS15395	COG2311	Membrane
I6I48_RS15400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I48_RS15425	COG0662	Cupin 2, conserved barrel domain protein
I6I48_RS15430	COG5285	phytanoyl-CoA dioxygenase
I6I48_RS15435	COG0633	Ferredoxin
I6I48_RS15435	COG3217	Mosc domain protein beta barrel domain protein
I6I48_RS15440	COG2076	Multidrug Resistance protein
I6I48_RS15455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_RS15470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I48_RS15475	COG0425	Belongs to the sulfur carrier protein TusA family
I6I48_RS15485	COG0228	four-way junction DNA binding
I6I48_RS15495	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I48_RS15500	COG1396	sequence-specific DNA binding
I6I48_RS15505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS15510	COG0765	amino acid transport
I6I48_RS15515	COG1126	abc transporter atp-binding protein
I6I48_RS15520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_RS15525	COG0525	valine-tRNA ligase activity
I6I48_RS15530	COG0105	UTP biosynthetic process
I6I48_RS15535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I48_RS15555	COG2976	Protein conserved in bacteria
I6I48_RS15560	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I48_RS15565	COG1160	GTP binding
I6I48_RS15570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I48_RS15575	COG1923	regulation of RNA biosynthetic process
I6I48_RS15580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I48_RS15585	COG0330	HflC and HflK could
I6I48_RS15590	COG0330	HflC and HflK could
I6I48_RS15595	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I48_RS15600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I48_RS15605	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6I48_RS15610	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I48_RS15620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I48_RS15630	COG0438	transferase activity, transferring glycosyl groups
I6I48_RS15640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I48_RS15640	COG2755	lipolytic protein G-D-S-L family
I6I48_RS15665	COG1475	DNA binding
I6I48_RS15675	COG3723	Recombinational DNA repair protein, rece pathway
I6I48_RS15680	COG5377	YqaJ viral recombinase family
I6I48_RS15755	COG2433	Pfam Transposase IS66
I6I48_RS15815	COG5410	chromosome segregation
I6I48_RS15825	COG2369	cell adhesion
I6I48_RS16000	COG4964	Belongs to the GSP D family
I6I48_RS16030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I48_RS16040	COG1295	ribonuclease BN
I6I48_RS16050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I48_RS16075	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I48_RS16170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_RS16175	COG2274	protein secretion by the type I secretion system
I6I48_RS16185	COG1538	Outer membrane efflux protein
I6I48_RS16205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I48_RS16215	COG0101	tRNA pseudouridine synthase activity
I6I48_RS16220	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I48_RS16250	COG0596	Alpha beta hydrolase
I6I48_RS16285	COG0129	dihydroxy-acid dehydratase activity
I6I48_RS16290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_RS16295	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_RS16300	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I48_RS16305	COG1609	Transcriptional regulator
I6I48_RS16325	COG4172	Belongs to the ABC transporter superfamily
I6I48_RS16330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS16335	COG0601	transmembrane transport
I6I48_RS16345	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_RS16375	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I48_RS16380	COG2197	response regulator
I6I48_RS16390	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I48_RS16395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I48_RS16410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I48_RS16415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I48_RS16420	COG0004	ammonium transporteR
I6I48_RS16425	COG0347	Belongs to the P(II) protein family
I6I48_RS16435	COG2960	long-chain fatty acid transporting porin activity
I6I48_RS16445	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I48_RS16450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I48_RS16455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I48_RS16460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I48_RS16460	COG0072	phenylalanine-tRNA ligase activity
I6I48_RS16490	COG2814	Major facilitator Superfamily
I6I48_RS16515	COG0384	phenazine biosynthesis protein PhzF
I6I48_RS16520	COG0456	acetyltransferase
I6I48_RS16555	COG1522	sequence-specific DNA binding
I6I48_RS16585	COG0583	DNA-binding transcription factor activity
I6I48_RS16590	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS16615	COG1116	anion transmembrane transporter activity
I6I48_RS16645	COG5265	(ABC) transporter
I6I48_RS16650	COG0656	L-ascorbic acid biosynthetic process
I6I48_RS16665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I48_RS16675	COG4977	sequence-specific DNA binding
I6I48_RS16675	COG1917	Cupin 2, conserved barrel domain protein
I6I48_RS16680	COG2223	nitrite transmembrane transporter activity
I6I48_RS16690	COG1215	transferase activity, transferring glycosyl groups
I6I48_RS16695	COG1649	PFAM Uncharacterised BCR, COG1649
I6I48_RS16695	COG0726	polysaccharide deacetylase
I6I48_RS16700	COG0457	Tetratricopeptide repeat
I6I48_RS16730	COG1610	YqeY-like protein
I6I48_RS16735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I48_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS16780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I48_RS16790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I48_RS16795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I48_RS16825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_RS16830	COG0697	spore germination
I6I48_RS16835	COG0506	proline dehydrogenase activity
I6I48_RS16855	COG0583	DNA-binding transcription factor activity
I6I48_RS16860	COG0583	DNA-binding transcription factor activity
I6I48_RS16865	COG0625	glutathione transferase activity
I6I48_RS16880	COG2814	Major facilitator Superfamily
I6I48_RS16885	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I48_RS16900	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS16905	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS16945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I48_RS16955	COG3245	cytochrome
I6I48_RS16960	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I48_RS16975	COG1280	lysine exporter protein (LysE YggA)
I6I48_RS16990	COG0697	spore germination
I6I48_RS16995	COG0697	spore germination
I6I48_RS17010	COG0534	Mate efflux family protein
I6I48_RS17015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I48_RS17020	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS17030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I48_RS17035	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I48_RS17045	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS17080	COG2207	Transcriptional regulator
I6I48_RS17095	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS17100	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS17105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I48_RS17110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I48_RS17120	COG1304	FMN binding
I6I48_RS17170	COG3088	subunit of a heme lyase
I6I48_RS17175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_RS17185	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I48_RS17205	COG4133	protoheme IX ABC transporter activity
I6I48_RS17225	COG3381	protein complex oligomerization
I6I48_RS17245	COG4235	cytochrome complex assembly
I6I48_RS17255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_RS17265	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I48_RS17285	COG4133	protoheme IX ABC transporter activity
I6I48_RS17290	COG3005	denitrification pathway
I6I48_RS17295	COG3043	anaerobic respiration
I6I48_RS17315	COG3246	L-lysine catabolic process to acetate
I6I48_RS17320	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_RS17325	COG0583	DNA-binding transcription factor activity
I6I48_RS17335	COG0129	dihydroxy-acid dehydratase activity
I6I48_RS17340	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS17345	COG5001	Diguanylate cyclase
I6I48_RS17350	COG1024	Enoyl-CoA hydratase
I6I48_RS17380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_RS17390	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6I48_RS17395	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS17400	COG0583	DNA-binding transcription factor activity
I6I48_RS17405	COG2610	gluconate transmembrane transporter activity
I6I48_RS17445	COG0235	Class ii aldolase
I6I48_RS17450	COG0477	Major facilitator Superfamily
I6I48_RS17465	COG2188	Transcriptional regulator
I6I48_RS17470	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS17510	COG1280	lysine exporter protein (LysE YggA)
I6I48_RS17515	COG5265	(ABC) transporter
I6I48_RS17525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_RS17540	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS17545	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS17580	COG0583	DNA-binding transcription factor activity
I6I48_RS17590	COG0583	DNA-binding transcription factor activity
I6I48_RS17600	COG0583	DNA-binding transcription factor activity
I6I48_RS17625	COG2226	methyltransferase
I6I48_RS17635	COG2814	Major facilitator Superfamily
I6I48_RS17640	COG0154	amidase activity
I6I48_RS17690	COG2070	2-Nitropropane dioxygenase
I6I48_RS17735	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS17745	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_RS17750	COG0307	riboflavin synthase, alpha
I6I48_RS17760	COG2271	Major facilitator Superfamily
I6I48_RS17770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I48_RS17780	COG0789	Transcriptional regulator
I6I48_RS17805	COG4774	siderophore transport
I6I48_RS17815	COG0022	dehydrogenase e1 component
I6I48_RS17835	COG1724	mRNA binding
I6I48_RS17840	COG1598	PFAM Uncharacterised protein family UPF0150
I6I48_RS17845	COG0165	Argininosuccinate lyase
I6I48_RS17850	COG0668	transmembrane transport
I6I48_RS17920	COG2165	general secretion pathway protein
I6I48_RS17950	COG0583	DNA-binding transcription factor activity
I6I48_RS17960	COG0747	negative chemotaxis
I6I48_RS17965	COG0601	transmembrane transport
I6I48_RS17970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS17975	COG4172	Belongs to the ABC transporter superfamily
I6I48_RS17980	COG4681	YaeQ
I6I48_RS17995	COG0477	Major facilitator Superfamily
I6I48_RS18000	COG3161	chorismate lyase activity
I6I48_RS18005	COG1187	pseudouridine synthase activity
I6I48_RS18010	COG0583	DNA-binding transcription factor activity
I6I48_RS18035	COG1999	signal sequence binding
I6I48_RS18045	COG0339	signal peptide processing
I6I48_RS18050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I48_RS18055	COG4566	intracellular signal transduction
I6I48_RS18065	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I48_RS18070	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I48_RS18075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I48_RS18085	COG0583	DNA-binding transcription factor activity
I6I48_RS18110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I48_RS18115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I48_RS18125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I48_RS18135	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I6I48_RS18145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I48_RS18160	COG1191	sigma factor activity
I6I48_RS18180	COG1360	Flagellar Motor Protein
I6I48_RS18185	COG0745	RESPONSE REGULATOR receiver
I6I48_RS18195	COG0835	chemotaxis
I6I48_RS18200	COG0840	transmembrane signaling receptor activity
I6I48_RS18205	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I48_RS18210	COG2201	protein-glutamate methylesterase activity
I6I48_RS18215	COG0745	RESPONSE REGULATOR receiver
I6I48_RS18220	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6I48_RS18225	COG0840	transmembrane signaling receptor activity
I6I48_RS18250	COG2747	anti-sigma28 factor FlgM
I6I48_RS18260	COG1815	bacterial-type flagellum-dependent cell motility
I6I48_RS18265	COG1558	bacterial-type flagellum-dependent cell motility
I6I48_RS18280	COG4787	bacterial-type flagellum-dependent cell motility
I6I48_RS18315	COG0840	transmembrane signaling receptor activity
I6I48_RS18330	COG0840	transmembrane signaling receptor activity
I6I48_RS18335	COG0840	transmembrane signaling receptor activity
I6I48_RS18370	COG1580	Controls the rotational direction of flagella during chemotaxis
I6I48_RS18395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I48_RS18400	COG1766	The M ring may be actively involved in energy transduction
I6I48_RS18405	COG1677	Flagellar hook-basal body complex protein FliE
I6I48_RS18415	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I48_RS18435	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6I48_RS18440	COG1334	flagellar protein FlaG
I6I48_RS18445	COG1414	Transcriptional regulator
I6I48_RS18455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_RS18460	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS18470	COG0285	dihydrofolate synthase activity
I6I48_RS18490	COG1451	nucleotide metabolic process
I6I48_RS18495	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I48_RS18505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I48_RS18510	COG0024	Methionine aminopeptidase
I6I48_RS18515	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I48_RS18520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I48_RS18525	COG0528	UMP kinase activity
I6I48_RS18530	COG0233	cytoplasmic translational termination
I6I48_RS18535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I48_RS18540	COG0575	Belongs to the CDS family
I6I48_RS18545	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I48_RS18550	COG0750	zinc metalloprotease
I6I48_RS18555	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I48_RS18560	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6I48_RS18565	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I48_RS18570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I48_RS18585	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I48_RS18590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I48_RS18610	COG2169	Transcriptional regulator
I6I48_RS18610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I48_RS18615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I48_RS18615	COG0519	Catalyzes the synthesis of GMP from XMP
I6I48_RS18635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I48_RS18640	COG2867	negative regulation of translational initiation
I6I48_RS18645	COG2914	Belongs to the UPF0125 (RnfH) family
I6I48_RS18655	COG1024	Enoyl-CoA hydratase
I6I48_RS18655	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_RS18685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I48_RS18690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I48_RS18695	COG0084	hydrolase, TatD family'
I6I48_RS18710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS18715	COG0765	amino acid transport
I6I48_RS18720	COG1126	abc transporter atp-binding protein
I6I48_RS18725	COG0010	Belongs to the arginase family
I6I48_RS18735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I48_RS18745	COG0095	Lipoate-protein ligase
I6I48_RS18760	COG0625	glutathione transferase activity
I6I48_RS18770	COG1522	sequence-specific DNA binding
I6I48_RS18775	COG0386	Belongs to the glutathione peroxidase family
I6I48_RS18780	COG2814	Major facilitator Superfamily
I6I48_RS18800	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I48_RS18810	COG0840	transmembrane signaling receptor activity
I6I48_RS18820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_RS18855	COG1902	pentaerythritol trinitrate reductase activity
I6I48_RS18885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I48_RS18900	COG0842	Transport permease protein
I6I48_RS18905	COG1131	(ABC) transporter
I6I48_RS18920	COG2130	NADP-dependent
I6I48_RS18945	COG3842	ATPase activity
I6I48_RS18950	COG3842	ATPase activity
I6I48_RS18960	COG0395	ABC-type sugar transport system, permease component
I6I48_RS19005	COG0346	lactoylglutathione lyase activity
I6I48_RS19010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_RS19030	COG3634	alkyl hydroperoxide reductase activity
I6I48_RS19035	COG1959	2 iron, 2 sulfur cluster binding
I6I48_RS19040	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS19075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_RS19080	COG0420	3'-5' exonuclease activity
I6I48_RS19110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I48_RS19110	COG2111	Na H antiporter
I6I48_RS19115	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I48_RS19120	COG0651	ATP synthesis coupled electron transport
I6I48_RS19125	COG1863	multisubunit Na H antiporter MnhE subunit
I6I48_RS19130	COG2212	antiporter activity
I6I48_RS19135	COG1320	monovalent cation:proton antiporter activity
I6I48_RS19155	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6I48_RS19160	COG0488	(ABC) transporter
I6I48_RS19195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_RS19200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_RS19210	COG2252	PERMEase
I6I48_RS19215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I48_RS19220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I48_RS19255	COG0583	DNA-binding transcription factor activity
I6I48_RS19260	COG2814	Major facilitator Superfamily
I6I48_RS19265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I48_RS19270	COG0789	Transcriptional regulator
I6I48_RS19285	COG0678	peroxiredoxin activity
I6I48_RS19285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I48_RS19295	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I48_RS19300	COG0584	glycerophosphoryl diester phosphodiesterase
I6I48_RS19310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_RS19320	COG4181	ATPase activity
I6I48_RS19330	COG1178	ABC-type Fe3 transport system permease component
I6I48_RS19335	COG3842	ATPase activity
I6I48_RS19340	COG0583	DNA-binding transcription factor activity
I6I48_RS19345	COG0560	Phosphoserine phosphatase
I6I48_RS19360	COG0583	DNA-binding transcription factor activity
I6I48_RS19375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_RS19390	COG0583	DNA-binding transcription factor activity
I6I48_RS19395	COG4336	lyase activity
I6I48_RS19425	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_RS19445	COG2816	NAD+ diphosphatase activity
I6I48_RS19470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS19475	COG0765	amino acid transport
I6I48_RS19480	COG1126	abc transporter atp-binding protein
I6I48_RS19485	COG1335	isochorismatase
I6I48_RS19495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I48_RS19500	COG1758	RNA polymerase activity
I6I48_RS19505	COG0194	GDP metabolic process
I6I48_RS19510	COG3258	Cytochrome c
I6I48_RS19515	COG2863	cytochrome
I6I48_RS19520	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS19525	COG0791	NLP P60 protein
I6I48_RS19540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I48_RS19545	COG0833	amino acid
I6I48_RS19550	COG1561	YicC-like family, N-terminal region
I6I48_RS19555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I48_RS19565	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS19580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I48_RS19585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I48_RS19590	COG0174	glutamine synthetase
I6I48_RS19600	COG2204	response regulator
I6I48_RS19605	COG0583	DNA-binding transcription factor activity
I6I48_RS19610	COG1741	Belongs to the pirin family
I6I48_RS19615	COG1741	Belongs to the pirin family
I6I48_RS19620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6I48_RS19625	COG1690	Belongs to the RtcB family
I6I48_RS19630	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS19635	COG3842	ATPase activity
I6I48_RS19640	COG4149	molybdate abc transporter
I6I48_RS19645	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I48_RS19655	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS19670	COG0583	DNA-binding transcription factor activity
I6I48_RS19680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I48_RS19690	COG0783	Belongs to the Dps family
I6I48_RS19700	COG0457	Tetratricopeptide repeat
I6I48_RS19705	COG0438	transferase activity, transferring glycosyl groups
I6I48_RS19730	COG1560	Kdo2-lipid A biosynthetic process
I6I48_RS19730	COG4783	chaperone-mediated protein folding
I6I48_RS19735	COG3866	Pectate lyase
I6I48_RS19750	COG0745	RESPONSE REGULATOR receiver
I6I48_RS19755	COG2205	protein histidine kinase activity
I6I48_RS19770	COG3842	ATPase activity
I6I48_RS19775	COG0395	ABC-type sugar transport system, permease component
I6I48_RS19780	COG1175	transmembrane transport
I6I48_RS19785	COG1653	transport
I6I48_RS19795	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I48_RS19810	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS19835	COG1794	racemase activity, acting on amino acids and derivatives
I6I48_RS19840	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I48_RS19850	COG0583	DNA-binding transcription factor activity
I6I48_RS19855	COG0625	glutathione transferase activity
I6I48_RS19860	COG2133	pyrroloquinoline quinone binding
I6I48_RS19870	COG0697	spore germination
I6I48_RS19875	COG2363	Small membrane protein
I6I48_RS19900	COG0010	Belongs to the arginase family
I6I48_RS19905	COG1464	Belongs to the NlpA lipoprotein family
I6I48_RS19915	COG2814	Major facilitator Superfamily
I6I48_RS19925	COG1408	metallophosphoesterase
I6I48_RS19935	COG0688	phosphatidylethanolamine metabolic process
I6I48_RS19940	COG0488	(ABC) transporter
I6I48_RS19965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_RS19970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6I48_RS19975	COG3300	MHYT domain
I6I48_RS19975	COG5001	Diguanylate cyclase
I6I48_RS19990	COG2814	Major facilitator Superfamily
I6I48_RS20015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I48_RS20020	COG2204	response regulator
I6I48_RS20055	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS20075	COG0693	protein deglycase activity
I6I48_RS20095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I48_RS20110	COG3300	MHYT domain
I6I48_RS20110	COG5001	Diguanylate cyclase
I6I48_RS20125	COG4774	siderophore transport
I6I48_RS20160	COG1253	flavin adenine dinucleotide binding
I6I48_RS20175	COG2205	protein histidine kinase activity
I6I48_RS20340	COG0789	Transcriptional regulator
I6I48_RS20350	COG3706	GGDEF domain
I6I48_RS20380	COG1116	anion transmembrane transporter activity
I6I48_RS20385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS20390	COG4521	taurine ABC transporter
I6I48_RS20410	COG0793	Belongs to the peptidase S41A family
I6I48_RS20430	COG0628	permease
I6I48_RS20440	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6I48_RS20455	COG0531	amino acid
I6I48_RS20465	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I48_RS20470	COG4608	Belongs to the ABC transporter superfamily
I6I48_RS20475	COG0444	Belongs to the ABC transporter superfamily
I6I48_RS20485	COG0601	transmembrane transport
I6I48_RS20490	COG0747	negative chemotaxis
I6I48_RS20500	COG0251	oxidation-reduction process
I6I48_RS20520	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I48_RS20535	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6I48_RS20550	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I48_RS20560	COG3971	2-oxopent-4-enoate hydratase activity
I6I48_RS20590	COG0625	glutathione transferase activity
I6I48_RS20605	COG0477	Major facilitator Superfamily
I6I48_RS20615	COG0579	oxidoreductase
I6I48_RS20630	COG0625	glutathione transferase activity
I6I48_RS20645	COG0431	NADPH-dependent FMN reductase
I6I48_RS20655	COG0798	PFAM Bile acid sodium symporter
I6I48_RS20665	COG0640	Transcriptional regulator
I6I48_RS20675	COG0668	transmembrane transport
I6I48_RS20695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_RS20700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_RS20720	COG0583	DNA-binding transcription factor activity
I6I48_RS20725	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6I48_RS20730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I48_RS20735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I48_RS20740	COG1045	serine acetyltransferase
I6I48_RS20750	COG2957	Belongs to the agmatine deiminase family
I6I48_RS20755	COG0583	DNA-binding transcription factor activity
I6I48_RS20775	COG1126	abc transporter atp-binding protein
I6I48_RS20780	COG0765	amino acid transport
I6I48_RS20785	COG4597	amino acid ABC transporter
I6I48_RS20790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS20795	COG0626	cystathionine gamma-synthase activity
I6I48_RS20800	COG0583	DNA-binding transcription factor activity
I6I48_RS20820	COG0444	Belongs to the ABC transporter superfamily
I6I48_RS20825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS20830	COG0601	transmembrane transport
I6I48_RS20835	COG0747	negative chemotaxis
I6I48_RS20845	COG0583	DNA-binding transcription factor activity
I6I48_RS20850	COG1335	isochorismatase
I6I48_RS20855	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I48_RS20865	COG2358	TRAP transporter, solute receptor (TAXI family
I6I48_RS20870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS20875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS20885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_RS20890	COG0519	Catalyzes the synthesis of GMP from XMP
I6I48_RS20890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I48_RS20900	COG1276	copper resistance
I6I48_RS20920	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS20925	COG3386	PFAM SMP-30 Gluconolaconase
I6I48_RS20930	COG2721	sulfolactate sulfo-lyase activity
I6I48_RS20945	COG0642	Histidine kinase
I6I48_RS20950	COG0745	RESPONSE REGULATOR receiver
I6I48_RS20960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_RS20965	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6I48_RS20970	COG3842	ATPase activity
I6I48_RS20975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I48_RS20990	COG0586	Pfam SNARE associated Golgi protein
I6I48_RS20995	COG0390	transport system, permease component
I6I48_RS21005	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6I48_RS21050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_RS21055	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_RS21060	COG1120	ATPase activity
I6I48_RS21065	COG1126	abc transporter atp-binding protein
I6I48_RS21070	COG0765	amino acid transport
I6I48_RS21075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS21080	COG2070	2-Nitropropane dioxygenase
I6I48_RS21085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I48_RS21095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I48_RS21120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I48_RS21125	COG0583	DNA-binding transcription factor activity
I6I48_RS21135	COG1846	Transcriptional regulator
I6I48_RS21145	COG4191	Histidine kinase
I6I48_RS21150	COG4566	intracellular signal transduction
I6I48_RS21190	COG0583	DNA-binding transcription factor activity
I6I48_RS21210	COG1126	abc transporter atp-binding protein
I6I48_RS21220	COG0765	amino acid transport
I6I48_RS21225	COG0436	Aminotransferase
I6I48_RS21250	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I48_RS21275	COG0251	oxidation-reduction process
I6I48_RS21290	COG4106	trans-aconitate 2-methyltransferase activity
I6I48_RS21315	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_RS21325	COG1802	Transcriptional regulator
I6I48_RS21330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_RS21345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I48_RS21370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS21375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_RS21380	COG1116	anion transmembrane transporter activity
I6I48_RS21415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS21420	COG4597	amino acid ABC transporter
I6I48_RS21425	COG3154	lipid carrier protein
I6I48_RS21430	COG0826	peptidase U32
I6I48_RS21435	COG0826	peptidase U32
I6I48_RS21440	COG2197	response regulator
I6I48_RS21445	COG3850	Histidine kinase
I6I48_RS21450	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6I48_RS21455	COG0288	reversible hydration of carbon dioxide
I6I48_RS21460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I48_RS21465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_RS21470	COG2181	nitrate reductase activity
I6I48_RS21475	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6I48_RS21480	COG1140	nitrate reductase beta subunit
I6I48_RS21485	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6I48_RS21490	COG2223	nitrite transmembrane transporter activity
I6I48_RS21535	COG0583	DNA-binding transcription factor activity
I6I48_RS21545	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS21575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS21595	COG2070	2-Nitropropane dioxygenase
I6I48_RS21610	COG5002	protein histidine kinase activity
I6I48_RS21615	COG0745	RESPONSE REGULATOR receiver
I6I48_RS21620	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6I48_RS21625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I48_RS21635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I48_RS21640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I48_RS21655	COG0783	Belongs to the Dps family
I6I48_RS21685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS21690	COG0697	spore germination
I6I48_RS21695	COG2879	small protein
I6I48_RS21700	COG1966	Carbon starvation protein
I6I48_RS21725	COG0583	DNA-binding transcription factor activity
I6I48_RS21730	COG4521	taurine ABC transporter
I6I48_RS21735	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I48_RS21740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS21755	COG2274	protein secretion by the type I secretion system
I6I48_RS21760	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I48_RS21770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS21785	COG0235	Class ii aldolase
I6I48_RS21790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_RS21805	COG1228	amidohydrolase
I6I48_RS21810	COG4172	Belongs to the ABC transporter superfamily
I6I48_RS21815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS21820	COG0601	transmembrane transport
I6I48_RS21825	COG0747	negative chemotaxis
I6I48_RS21840	COG1414	Transcriptional regulator
I6I48_RS21845	COG0513	Belongs to the DEAD box helicase family
I6I48_RS21850	COG0602	queuosine metabolic process
I6I48_RS21855	COG0720	synthase
I6I48_RS21865	COG1289	transmembrane transporter activity
I6I48_RS21875	COG1566	PFAM secretion protein HlyD family protein
I6I48_RS21890	COG0028	Belongs to the TPP enzyme family
I6I48_RS21900	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS21910	COG0400	carboxylic ester hydrolase activity
I6I48_RS21915	COG0833	amino acid
I6I48_RS21935	COG0587	DNA-directed DNA polymerase activity
I6I48_RS21955	COG0667	Aldo Keto reductase
I6I48_RS21965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I48_RS21975	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS21980	COG0583	DNA-binding transcription factor activity
I6I48_RS22020	COG3038	cytochrome b561
I6I48_RS22045	COG0840	transmembrane signaling receptor activity
I6I48_RS22125	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6I48_RS22145	COG4774	siderophore transport
I6I48_RS22150	COG2345	Transcriptional regulator
I6I48_RS22160	COG1414	Transcriptional regulator
I6I48_RS22170	COG0477	Major facilitator Superfamily
I6I48_RS22175	COG0667	Aldo Keto reductase
I6I48_RS22185	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS22190	COG1309	transcriptional regulator
I6I48_RS22210	COG1683	Conserved Protein
I6I48_RS22220	COG2207	Transcriptional regulator
I6I48_RS22240	COG2885	chlorophyll binding
I6I48_RS22240	COG3047	cAMP biosynthetic process
I6I48_RS22255	COG3795	YCII-related domain
I6I48_RS22260	COG3795	YCII-related domain
I6I48_RS22280	COG0697	spore germination
I6I48_RS22290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I48_RS22300	COG0583	DNA-binding transcription factor activity
I6I48_RS22335	COG1846	Transcriptional regulator
I6I48_RS22340	COG3541	Predicted nucleotidyltransferase
I6I48_RS22350	COG1414	Transcriptional regulator
I6I48_RS22355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I48_RS22375	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I48_RS22380	COG3971	2-oxopent-4-enoate hydratase activity
I6I48_RS22400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_RS22480	COG1360	Flagellar Motor Protein
I6I48_RS22490	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I6I48_RS22685	COG0625	glutathione transferase activity
I6I48_RS22690	COG2032	superoxide dismutase activity
I6I48_RS22695	COG2733	membrane
I6I48_RS22705	COG0148	phosphopyruvate hydratase activity
I6I48_RS22730	COG0583	DNA-binding transcription factor activity
I6I48_RS22735	COG1024	Enoyl-CoA hydratase
I6I48_RS22735	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_RS22740	COG0183	Belongs to the thiolase family
I6I48_RS22745	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS22750	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS22755	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS22765	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I48_RS22780	COG0583	DNA-binding transcription factor activity
I6I48_RS22795	COG4771	TonB-dependent receptor
I6I48_RS22800	COG2814	Major facilitator Superfamily
I6I48_RS22805	COG1846	Transcriptional regulator
I6I48_RS22810	COG0477	Major facilitator Superfamily
I6I48_RS22825	COG2080	2 iron, 2 sulfur cluster binding
I6I48_RS22835	COG0596	Alpha beta hydrolase
I6I48_RS22840	COG2309	aminopeptidase activity
I6I48_RS22845	COG1335	isochorismatase
I6I48_RS22850	COG2010	Cytochrome c
I6I48_RS22850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I48_RS22860	COG1522	sequence-specific DNA binding
I6I48_RS22865	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_RS22870	COG3842	ATPase activity
I6I48_RS22875	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I48_RS22880	COG4149	molybdate abc transporter
I6I48_RS22885	COG5001	Diguanylate cyclase
I6I48_RS22885	COG2203	Gaf domain
I6I48_RS22885	COG3706	GGDEF domain
I6I48_RS22885	COG4251	negative regulation of phosphorylation
I6I48_RS22890	COG2201	protein-glutamate methylesterase activity
I6I48_RS22915	COG0840	transmembrane signaling receptor activity
I6I48_RS22935	COG0583	DNA-binding transcription factor activity
I6I48_RS22965	COG0456	acetyltransferase
I6I48_RS22980	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS23010	COG2188	Transcriptional regulator
I6I48_RS23015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I48_RS23020	COG1070	Carbohydrate kinase
I6I48_RS23030	COG1129	ABC transporter
I6I48_RS23035	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS23040	COG0667	Aldo Keto reductase
I6I48_RS23050	COG1864	DNA RNA non-specific endonuclease
I6I48_RS23050	COG3591	Belongs to the peptidase S1B family
I6I48_RS23090	COG0165	Argininosuccinate lyase
I6I48_RS23105	COG0583	DNA-binding transcription factor activity
I6I48_RS23120	COG2205	protein histidine kinase activity
I6I48_RS23140	COG2207	Transcriptional regulator
I6I48_RS23145	COG4221	oxidoreductase activity
I6I48_RS23150	COG2207	Transcriptional regulator
I6I48_RS23175	COG0640	Transcriptional regulator
I6I48_RS23180	COG0640	Transcriptional regulator
I6I48_RS23190	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I48_RS23195	COG0583	DNA-binding transcription factor activity
I6I48_RS23200	COG0431	NADPH-dependent FMN reductase
I6I48_RS23230	COG4264	IucA IucC family
I6I48_RS23260	COG5002	protein histidine kinase activity
I6I48_RS23270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I48_RS23270	COG0519	Catalyzes the synthesis of GMP from XMP
I6I48_RS23300	COG0583	DNA-binding transcription factor activity
I6I48_RS23310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I48_RS23330	COG0583	DNA-binding transcription factor activity
I6I48_RS23335	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS23380	COG2072	flavoprotein involved in K transport
I6I48_RS23385	COG0601	transmembrane transport
I6I48_RS23390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS23400	COG4608	Belongs to the ABC transporter superfamily
I6I48_RS23405	COG0747	negative chemotaxis
I6I48_RS23435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I48_RS23465	COG4774	siderophore transport
I6I48_RS23495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I48_RS23520	COG0583	DNA-binding transcription factor activity
I6I48_RS23565	COG5001	Diguanylate cyclase
I6I48_RS23570	COG4774	siderophore transport
I6I48_RS23575	COG4774	siderophore transport
I6I48_RS23590	COG0583	DNA-binding transcription factor activity
I6I48_RS23640	COG1953	Uracil, thiamine, allantoin
I6I48_RS23680	COG0583	DNA-binding transcription factor activity
I6I48_RS23685	COG2205	protein histidine kinase activity
I6I48_RS23685	COG2198	Histidine kinase
I6I48_RS23685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS23685	COG0784	Response regulator, receiver
I6I48_RS23690	COG0745	RESPONSE REGULATOR receiver
I6I48_RS23690	COG2205	protein histidine kinase activity
I6I48_RS23690	COG3292	Two component regulator propeller
I6I48_RS23715	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS23725	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I48_RS23740	COG0583	DNA-binding transcription factor activity
I6I48_RS23760	COG0642	Histidine kinase
I6I48_RS23785	COG1595	DNA-templated transcription, initiation
I6I48_RS23790	COG3712	iron ion homeostasis
I6I48_RS23795	COG4774	siderophore transport
I6I48_RS23800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I48_RS23800	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I48_RS23810	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I48_RS23810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_RS23815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_RS23855	COG0613	PHP domain protein
I6I48_RS23870	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I48_RS23880	COG0583	DNA-binding transcription factor activity
I6I48_RS23890	COG0583	DNA-binding transcription factor activity
I6I48_RS23895	COG0477	Major facilitator Superfamily
I6I48_RS23900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I48_RS23910	COG0159	tryptophan synthase activity
I6I48_RS23945	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I48_RS23955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I48_RS23960	COG0459	protein refolding
I6I48_RS23985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I48_RS23990	COG0714	Associated with various cellular activities
I6I48_RS24010	COG2304	oxidoreductase activity
I6I48_RS24025	COG3119	arylsulfatase activity
I6I48_RS24035	COG1280	lysine exporter protein (LysE YggA)
I6I48_RS24065	COG0633	Ferredoxin
I6I48_RS24070	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS24075	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS24085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I48_RS24125	COG4604	ABC transporter, ATP-binding protein
I6I48_RS24130	COG4605	iron ion homeostasis
I6I48_RS24135	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_RS24140	COG4607	ABC-type enterochelin transport system periplasmic component
I6I48_RS24145	COG4771	TonB-dependent receptor
I6I48_RS24150	COG0745	RESPONSE REGULATOR receiver
I6I48_RS24160	COG0084	hydrolase, TatD family'
I6I48_RS24165	COG1136	(ABC) transporter
I6I48_RS24185	COG2271	Major facilitator Superfamily
I6I48_RS24195	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS24200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I48_RS24215	COG3135	benzoate transporter
I6I48_RS24220	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I48_RS24225	COG1309	transcriptional regulator
I6I48_RS24230	COG0183	Belongs to the thiolase family
I6I48_RS24235	COG1022	Amp-dependent synthetase and ligase
I6I48_RS24265	COG1024	Enoyl-CoA hydratase
I6I48_RS24350	COG1196	nuclear chromosome segregation
I6I48_RS24400	COG0740	serine-type endopeptidase activity
I6I48_RS24405	COG4695	Portal protein
I6I48_RS24440	COG1598	PFAM Uncharacterised protein family UPF0150
I6I48_RS24545	COG0592	DNA-directed DNA polymerase activity
I6I48_RS24565	COG3561	AntA/AntB antirepressor
I6I48_RS24585	COG0582	viral genome integration into host DNA
I6I48_RS24595	COG1803	Methylglyoxal synthase
I6I48_RS24600	COG2975	iron-sulfur cluster assembly
I6I48_RS24605	COG0633	Ferredoxin
I6I48_RS24610	COG0443	Heat shock 70 kDa protein
I6I48_RS24615	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6I48_RS24620	COG0316	Belongs to the HesB IscA family
I6I48_RS24625	COG0822	iron-sulfur transferase activity
I6I48_RS24630	COG1104	cysteine desulfurase activity
I6I48_RS24640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I48_RS24645	COG0556	nucleotide-excision repair
I6I48_RS24655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I48_RS24660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I48_RS24665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I48_RS24670	COG0740	serine-type endopeptidase activity
I6I48_RS24675	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I48_RS24680	COG0501	Belongs to the peptidase M48B family
I6I48_RS24690	COG1278	Cold shock
I6I48_RS24700	COG1278	Cold shock
I6I48_RS24725	COG0251	oxidation-reduction process
I6I48_RS24735	COG0583	DNA-binding transcription factor activity
I6I48_RS24770	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I48_RS24795	COG0277	FAD linked oxidase domain protein
I6I48_RS24810	COG2814	Major facilitator Superfamily
I6I48_RS24845	COG2171	N-acyltransferase activity
I6I48_RS24855	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I48_RS24860	COG0488	(ABC) transporter
I6I48_RS24875	COG4771	TonB-dependent receptor
I6I48_RS24880	COG4771	TonB-dependent receptor
I6I48_RS24885	COG4771	TonB-dependent receptor
I6I48_RS24895	COG1858	cytochrome C peroxidase
I6I48_RS24905	COG0210	DNA helicase
I6I48_RS24920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I48_RS24920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I48_RS24925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I48_RS24930	COG0196	riboflavin kinase activity
I6I48_RS24935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I48_RS24940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I48_RS24945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I48_RS24995	COG1902	pentaerythritol trinitrate reductase activity
I6I48_RS25000	COG1126	abc transporter atp-binding protein
I6I48_RS25005	COG0765	amino acid transport
I6I48_RS25010	COG0765	amino acid transport
I6I48_RS25015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS25025	COG2423	ornithine cyclodeaminase activity
I6I48_RS25030	COG1764	response to oxidative stress
I6I48_RS25040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_RS25045	COG0625	glutathione transferase activity
I6I48_RS25055	COG4178	(ABC) transporter
I6I48_RS25060	COG4771	TonB-dependent receptor
I6I48_RS25075	COG2271	Major facilitator Superfamily
I6I48_RS25105	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I48_RS25105	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6I48_RS25105	COG0506	proline dehydrogenase activity
I6I48_RS25115	COG3008	intermembrane lipid transfer
I6I48_RS25120	COG2995	paraquat-inducible protein a
I6I48_RS25130	COG4953	penicillin-binding protein 1C
I6I48_RS25135	COG2373	Large extracellular alpha-helical protein
I6I48_RS25140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I48_RS25145	COG1278	Cold shock
I6I48_RS25155	COG0183	Belongs to the thiolase family
I6I48_RS25160	COG0038	chloride channel
I6I48_RS25170	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I48_RS25180	COG1570	exodeoxyribonuclease VII activity
I6I48_RS25185	COG0811	peptide transport
I6I48_RS25195	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I48_RS25205	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I48_RS25210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I48_RS25215	COG0563	adenylate kinase activity
I6I48_RS25225	COG0728	peptidoglycan biosynthetic process
I6I48_RS25235	COG0268	Binds directly to 16S ribosomal RNA
I6I48_RS25240	COG0583	DNA-binding transcription factor activity
I6I48_RS25255	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS25260	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I48_RS25265	COG2186	Transcriptional regulator
I6I48_RS25275	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS25280	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS25285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I48_RS25315	COG3384	dioxygenase
I6I48_RS25320	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_RS25335	COG3971	2-oxopent-4-enoate hydratase activity
I6I48_RS25345	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS25350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I48_RS25355	COG1562	ergosterol biosynthetic process
I6I48_RS25360	COG1562	ergosterol biosynthetic process
I6I48_RS25370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I48_RS25395	COG1477	protein flavinylation
I6I48_RS25400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I48_RS25410	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6I48_RS25425	COG5564	TIM-barrel signal transduction protein
I6I48_RS25430	COG5441	Belongs to the UPF0261 family
I6I48_RS25455	COG0542	response to heat
I6I48_RS25465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I48_RS25475	COG0477	Major facilitator Superfamily
I6I48_RS25495	COG0494	nUDIX hydrolase
I6I48_RS25500	COG0583	DNA-binding transcription factor activity
I6I48_RS25505	COG0443	Heat shock 70 kDa protein
I6I48_RS25540	COG2814	Major facilitator Superfamily
I6I48_RS25550	COG3530	Putative quorum-sensing-regulated virulence factor
I6I48_RS25565	COG0625	glutathione transferase activity
I6I48_RS25590	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS25600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I48_RS25660	COG1522	sequence-specific DNA binding
I6I48_RS25670	COG4172	Belongs to the ABC transporter superfamily
I6I48_RS25685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS25695	COG0519	Catalyzes the synthesis of GMP from XMP
I6I48_RS25715	COG1595	DNA-templated transcription, initiation
I6I48_RS25735	COG0519	Catalyzes the synthesis of GMP from XMP
I6I48_RS25745	COG2951	lytic endotransglycosylase activity
I6I48_RS25760	COG0583	DNA-binding transcription factor activity
I6I48_RS25770	COG2272	Belongs to the type-B carboxylesterase lipase family
I6I48_RS25775	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS25780	COG1309	transcriptional regulator
I6I48_RS25790	COG1473	amidohydrolase
I6I48_RS25795	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS25810	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6I48_RS25825	COG3618	amidohydrolase
I6I48_RS25830	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS25865	COG2011	ABC-type metal ion transport system permease component
I6I48_RS25870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I48_RS25875	COG1464	Belongs to the NlpA lipoprotein family
I6I48_RS25885	COG2814	Major facilitator Superfamily
I6I48_RS25895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I48_RS25900	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_RS25940	COG2837	iron assimilation
I6I48_RS25950	COG0583	DNA-binding transcription factor activity
I6I48_RS25955	COG2814	Major facilitator Superfamily
I6I48_RS25960	COG2169	Transcriptional regulator
I6I48_RS25990	COG1272	protein, Hemolysin III
I6I48_RS26000	COG1278	Cold shock
I6I48_RS26030	COG4638	Rieske (2fe-2S)
I6I48_RS26045	COG3321	synthase
I6I48_RS26045	COG0604	alcohol dehydrogenase
I6I48_RS26060	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS26065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_RS26090	COG0183	Belongs to the thiolase family
I6I48_RS26105	COG0842	Transport permease protein
I6I48_RS26110	COG1131	(ABC) transporter
I6I48_RS26120	COG2197	response regulator
I6I48_RS26125	COG1116	anion transmembrane transporter activity
I6I48_RS26125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_RS26130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS26135	COG1116	anion transmembrane transporter activity
I6I48_RS26140	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6I48_RS26160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I48_RS26190	COG0811	peptide transport
I6I48_RS26250	COG1396	sequence-specific DNA binding
I6I48_RS26265	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS26310	COG1024	Enoyl-CoA hydratase
I6I48_RS26325	COG0583	DNA-binding transcription factor activity
I6I48_RS26380	COG3384	dioxygenase
I6I48_RS26425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_RS26430	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I48_RS26435	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I48_RS26450	COG1609	Transcriptional regulator
I6I48_RS26455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I48_RS26460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I48_RS26470	COG1850	ribulose-bisphosphate carboxylase activity
I6I48_RS26485	COG0505	Belongs to the CarA family
I6I48_RS26500	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6I48_RS26500	COG3608	succinylglutamate desuccinylase aspartoacylase
I6I48_RS26505	COG0583	DNA-binding transcription factor activity
I6I48_RS26520	COG1064	alcohol dehydrogenase
I6I48_RS26525	COG2207	Transcriptional regulator
I6I48_RS26530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS26620	COG2192	nodulation
I6I48_RS26630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6I48_RS26635	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS26640	COG0438	transferase activity, transferring glycosyl groups
I6I48_RS26650	COG5265	(ABC) transporter
I6I48_RS26670	COG0668	transmembrane transport
I6I48_RS26680	COG0166	Belongs to the GPI family
I6I48_RS26690	COG3685	Protein conserved in bacteria
I6I48_RS26710	COG0387	Pfam Sodium calcium exchanger
I6I48_RS26715	COG3568	Endonuclease Exonuclease Phosphatase
I6I48_RS26720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I48_RS26725	COG0392	lysyltransferase activity
I6I48_RS26730	COG0297	glycogen (starch) synthase activity
I6I48_RS26735	COG0366	Alpha amylase catalytic
I6I48_RS26740	COG0366	Alpha amylase catalytic
I6I48_RS26745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I48_RS26755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I48_RS26760	COG1640	4-alpha-glucanotransferase
I6I48_RS26770	COG1113	amino acid transport
I6I48_RS26795	COG1546	Belongs to the CinA family
I6I48_RS26795	COG1058	Belongs to the CinA family
I6I48_RS26805	COG3852	Histidine kinase
I6I48_RS26835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I48_RS26855	COG0477	Major facilitator Superfamily
I6I48_RS26870	COG5001	Diguanylate cyclase
I6I48_RS26870	COG1716	ATPase activity
I6I48_RS26895	COG5295	Hep Hag repeat protein
I6I48_RS26925	COG1120	ATPase activity
I6I48_RS26930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_RS26960	COG0596	Alpha beta hydrolase
I6I48_RS26975	COG1414	Transcriptional regulator
I6I48_RS26980	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I48_RS26985	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS26995	COG2721	sulfolactate sulfo-lyase activity
I6I48_RS27005	COG0765	amino acid transport
I6I48_RS27015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS27020	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_RS27030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I48_RS27035	COG3958	Transketolase
I6I48_RS27040	COG3959	Transketolase, thiamine diphosphate binding domain
I6I48_RS27045	COG1802	Transcriptional regulator
I6I48_RS27050	COG0371	Dehydrogenase
I6I48_RS27055	COG3246	L-lysine catabolic process to acetate
I6I48_RS27060	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_RS27065	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS27075	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS27090	COG3321	synthase
I6I48_RS27090	COG0604	alcohol dehydrogenase
I6I48_RS27090	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS27095	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS27125	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS27135	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I48_RS27160	COG2814	Major facilitator Superfamily
I6I48_RS27175	COG3384	dioxygenase
I6I48_RS27190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I48_RS27245	COG4964	Belongs to the GSP D family
I6I48_RS27290	COG1846	Transcriptional regulator
I6I48_RS27295	COG4172	Belongs to the ABC transporter superfamily
I6I48_RS27300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS27305	COG0601	transmembrane transport
I6I48_RS27320	COG0598	Magnesium transport protein CorA
I6I48_RS27340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I48_RS27355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I48_RS27360	COG1045	serine acetyltransferase
I6I48_RS27365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I48_RS27370	COG0166	Belongs to the GPI family
I6I48_RS27375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I48_RS27380	COG3206	protein involved in exopolysaccharide biosynthesis
I6I48_RS27380	COG0489	protein tyrosine kinase activity
I6I48_RS27385	COG1596	polysaccharide export
I6I48_RS27395	COG1051	belongs to the nudix hydrolase family
I6I48_RS27415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_RS27440	COG0463	Glycosyl transferase, family 2
I6I48_RS27445	COG0110	maltose O-acetyltransferase activity
I6I48_RS27450	COG0297	glycogen (starch) synthase activity
I6I48_RS27455	COG2197	response regulator
I6I48_RS27460	COG2197	response regulator
I6I48_RS27470	COG1309	transcriptional regulator
I6I48_RS27475	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS27485	COG1024	Enoyl-CoA hydratase
I6I48_RS27485	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_RS27495	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_RS27495	COG1024	Enoyl-CoA hydratase
I6I48_RS27500	COG0183	Belongs to the thiolase family
I6I48_RS27515	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS27525	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS27535	COG1132	(ABC) transporter
I6I48_RS27545	COG3395	kinase activity
I6I48_RS27550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I48_RS27560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I48_RS27565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6I48_RS27570	COG1024	Enoyl-CoA hydratase
I6I48_RS27580	COG1414	Transcriptional regulator
I6I48_RS27590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I48_RS27610	COG0583	DNA-binding transcription factor activity
I6I48_RS27650	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I48_RS27655	COG1309	transcriptional regulator
I6I48_RS27665	COG1051	belongs to the nudix hydrolase family
I6I48_RS27670	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6I48_RS27680	COG0784	Response regulator, receiver
I6I48_RS27680	COG2205	protein histidine kinase activity
I6I48_RS27690	COG2205	protein histidine kinase activity
I6I48_RS27690	COG0784	Response regulator, receiver
I6I48_RS27705	COG2863	cytochrome
I6I48_RS27710	COG3258	Cytochrome c
I6I48_RS27725	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I48_RS27745	COG0348	domain, Protein
I6I48_RS27760	COG0527	aspartate kinase activity
I6I48_RS27765	COG0037	tRNA processing
I6I48_RS27770	COG0825	malonyl-CoA metabolic process
I6I48_RS27780	COG0215	cysteine-tRNA ligase activity
I6I48_RS27795	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I48_RS27800	COG1968	undecaprenyl-diphosphatase activity
I6I48_RS27805	COG1253	flavin adenine dinucleotide binding
I6I48_RS27820	COG4263	nitrous-oxide reductase activity
I6I48_RS27835	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6I48_RS27845	COG1477	protein flavinylation
I6I48_RS27850	COG4804	nuclease activity
I6I48_RS27855	COG0483	inositol monophosphate 1-phosphatase activity
I6I48_RS27875	COG0668	transmembrane transport
I6I48_RS27915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_RS27920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS27925	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I48_RS27960	COG3360	Dodecin
I6I48_RS27970	COG0583	DNA-binding transcription factor activity
I6I48_RS27975	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS28030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I48_RS28035	COG2850	peptidyl-arginine hydroxylation
I6I48_RS28045	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6I48_RS28050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_RS28055	COG1994	Peptidase M50
I6I48_RS28060	COG0009	L-threonylcarbamoyladenylate synthase
I6I48_RS28065	COG2321	neutral zinc metallopeptidase
I6I48_RS28125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I48_RS28130	COG3969	phosphoadenosine phosphosulfate
I6I48_RS28140	COG1475	DNA binding
I6I48_RS28145	COG0642	Histidine kinase
I6I48_RS28165	COG3188	usher protein
I6I48_RS28170	COG3121	Chaperone
I6I48_RS28175	COG0840	transmembrane signaling receptor activity
I6I48_RS28205	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS28210	COG3387	PFAM Glycoside hydrolase 15-related
I6I48_RS28225	COG0840	transmembrane signaling receptor activity
I6I48_RS28230	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS28235	COG1280	lysine exporter protein (LysE YggA)
I6I48_RS28245	COG3246	L-lysine catabolic process to acetate
I6I48_RS28260	COG0402	S-adenosylhomocysteine deaminase activity
I6I48_RS28270	COG0582	viral genome integration into host DNA
I6I48_RS28280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I48_RS28290	COG2207	Transcriptional regulator
I6I48_RS28290	COG1917	Cupin 2, conserved barrel domain protein
I6I48_RS28300	COG2084	Dehydrogenase
I6I48_RS28320	COG1595	DNA-templated transcription, initiation
I6I48_RS28335	COG1802	Transcriptional regulator
I6I48_RS28350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I48_RS28380	COG2205	protein histidine kinase activity
I6I48_RS28385	COG1764	response to oxidative stress
I6I48_RS28400	COG0586	Pfam SNARE associated Golgi protein
I6I48_RS28405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I48_RS28410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I48_RS28465	COG3546	catalase activity
I6I48_RS28485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_RS28490	COG0765	amino acid transport
I6I48_RS28500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS28510	COG1012	belongs to the aldehyde dehydrogenase family
I6I48_RS28535	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS28555	COG0348	domain, Protein
I6I48_RS28575	COG3278	Belongs to the heme-copper respiratory oxidase family
I6I48_RS28590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I48_RS28595	COG0156	8-amino-7-oxononanoate synthase activity
I6I48_RS28620	COG2224	Isocitrate lyase
I6I48_RS28625	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I48_RS28625	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I48_RS28630	COG1858	cytochrome C peroxidase
I6I48_RS28635	COG0583	DNA-binding transcription factor activity
I6I48_RS28640	COG0473	3-isopropylmalate dehydrogenase activity
I6I48_RS28650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I48_RS28665	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I48_RS28670	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I48_RS28680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I48_RS28685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I48_RS28710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6I48_RS28715	COG4149	molybdate abc transporter
I6I48_RS28720	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I48_RS28725	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6I48_RS28750	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I48_RS28760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I48_RS28770	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS28780	COG0667	Aldo Keto reductase
I6I48_RS28790	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS28795	COG1024	Enoyl-CoA hydratase
I6I48_RS28805	COG1802	Transcriptional regulator
I6I48_RS28815	COG0183	Belongs to the thiolase family
I6I48_RS28820	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS28825	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS28830	COG0583	DNA-binding transcription factor activity
I6I48_RS28855	COG4213	ABC transporter substrate-binding protein
I6I48_RS28860	COG1129	ABC transporter
I6I48_RS28865	COG4214	carbohydrate transport
I6I48_RS28870	COG2706	6-phosphogluconolactonase activity
I6I48_RS28875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I48_RS28890	COG3448	diguanylate cyclase activity
I6I48_RS28890	COG4175	Glycine betaine
I6I48_RS28895	COG4176	ABC-type proline glycine betaine transport system permease component
I6I48_RS28905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I48_RS28910	COG2814	Major facilitator Superfamily
I6I48_RS28915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I48_RS28920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I48_RS28935	COG1129	ABC transporter
I6I48_RS28955	COG1686	Belongs to the peptidase S11 family
I6I48_RS28970	COG1846	Transcriptional regulator
I6I48_RS28975	COG2814	Major facilitator Superfamily
I6I48_RS28980	COG0495	leucyl-tRNA aminoacylation
I6I48_RS28995	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I48_RS29015	COG0154	amidase activity
I6I48_RS29025	COG0477	Major facilitator Superfamily
I6I48_RS29035	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I48_RS29050	COG0583	DNA-binding transcription factor activity
I6I48_RS29100	COG0583	DNA-binding transcription factor activity
I6I48_RS29105	COG0427	acetyl-CoA hydrolase
I6I48_RS29110	COG0583	DNA-binding transcription factor activity
I6I48_RS29115	COG3264	Mechanosensitive ion channel
I6I48_RS29115	COG1511	domain protein
I6I48_RS29165	COG3842	ATPase activity
I6I48_RS29170	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I48_RS29175	COG0395	ABC-type sugar transport system, permease component
I6I48_RS29180	COG3938	Belongs to the proline racemase family
I6I48_RS29190	COG0517	IMP dehydrogenase activity
I6I48_RS29220	COG0500	methyltransferase
I6I48_RS29235	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I6I48_RS29250	COG0667	Aldo Keto reductase
I6I48_RS29255	COG2207	Transcriptional regulator
I6I48_RS29260	COG0583	DNA-binding transcription factor activity
I6I48_RS29265	COG1335	isochorismatase
I6I48_RS29275	COG2841	Protein conserved in bacteria
I6I48_RS29290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I48_RS29295	COG0438	transferase activity, transferring glycosyl groups
I6I48_RS29310	COG2003	Belongs to the UPF0758 family
I6I48_RS29375	COG2433	Pfam Transposase IS66
I6I48_RS29390	COG2433	Pfam Transposase IS66
I6I48_RS29405	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS29410	COG0583	DNA-binding transcription factor activity
I6I48_RS29425	COG0028	Belongs to the TPP enzyme family
I6I48_RS29455	COG4774	siderophore transport
I6I48_RS29465	COG1595	DNA-templated transcription, initiation
I6I48_RS29475	COG0546	phosphoglycolate phosphatase activity
I6I48_RS29480	COG3842	ATPase activity
I6I48_RS29485	COG1175	transmembrane transport
I6I48_RS29490	COG0395	ABC-type sugar transport system, permease component
I6I48_RS29495	COG1653	transport
I6I48_RS29515	COG2814	Major facilitator Superfamily
I6I48_RS29520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I48_RS29545	COG0248	Ppx GppA phosphatase
I6I48_RS29555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I48_RS29565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I48_RS29570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I48_RS29575	COG1534	Rna-binding protein
I6I48_RS29580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I48_RS29585	COG0840	transmembrane signaling receptor activity
I6I48_RS29590	COG2233	PERMEase
I6I48_RS29610	COG3842	ATPase activity
I6I48_RS29625	COG4221	oxidoreductase activity
I6I48_RS29635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I48_RS29640	COG0505	Belongs to the CarA family
I6I48_RS29660	COG0745	RESPONSE REGULATOR receiver
I6I48_RS29675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS29685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_RS29690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_RS29705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I48_RS29715	COG1074	ATP-dependent DNA helicase activity
I6I48_RS29735	COG2070	2-Nitropropane dioxygenase
I6I48_RS29755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_RS29770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I48_RS29775	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS29790	COG1686	Belongs to the peptidase S11 family
I6I48_RS29805	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6I48_RS29810	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I48_RS29815	COG4974	Belongs to the 'phage' integrase family
I6I48_RS29820	COG0583	DNA-binding transcription factor activity
I6I48_RS29825	COG0028	Belongs to the TPP enzyme family
I6I48_RS29865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I48_RS29910	COG0028	Belongs to the TPP enzyme family
I6I48_RS29915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS29930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I48_RS29935	COG1414	Transcriptional regulator
I6I48_RS29940	COG0009	L-threonylcarbamoyladenylate synthase
I6I48_RS29945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I48_RS29950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I48_RS29955	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6I48_RS29965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I48_RS29985	COG1301	dicarboxylic acid transport
I6I48_RS29995	COG3454	Phosphonate metabolism
I6I48_RS30000	COG4778	phosphonate C-P lyase system protein PhnL
I6I48_RS30005	COG4107	phosphonate C-P lyase system protein PhnK
I6I48_RS30010	COG3627	carbon phosphorus lyase activity
I6I48_RS30015	COG3626	phosphonate metabolism
I6I48_RS30020	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6I48_RS30025	COG3624	Phosphonate C-P lyase system protein PhnG
I6I48_RS30030	COG2188	Transcriptional regulator
I6I48_RS30035	COG3454	Phosphonate metabolism
I6I48_RS30040	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I48_RS30045	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I48_RS30050	COG0583	DNA-binding transcription factor activity
I6I48_RS30055	COG0405	Gamma-glutamyltransferase
I6I48_RS30070	COG3639	organic phosphonate transmembrane transporter activity
I6I48_RS30075	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6I48_RS30080	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I48_RS30090	COG0640	Transcriptional regulator
I6I48_RS30100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I48_RS30110	COG0739	heme binding
I6I48_RS30120	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I48_RS30130	COG0306	phosphate transporter
I6I48_RS30165	COG0625	glutathione transferase activity
I6I48_RS30185	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I48_RS30190	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I48_RS30205	COG0126	phosphoglycerate kinase activity
I6I48_RS30210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I48_RS30215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I48_RS30225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I48_RS30230	COG2732	(Barnase) inhibitor
I6I48_RS30240	COG0281	malic enzyme
I6I48_RS30240	COG0280	phosphate acetyltransferase
I6I48_RS30250	COG0436	Aminotransferase
I6I48_RS30265	COG0741	lytic transglycosylase activity
I6I48_RS30270	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6I48_RS30285	COG4575	ribosome binding
I6I48_RS30295	COG1116	anion transmembrane transporter activity
I6I48_RS30300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS30305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I48_RS30310	COG1648	precorrin-2 dehydrogenase activity
I6I48_RS30310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I48_RS30315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I48_RS30320	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I48_RS30335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I48_RS30345	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I48_RS30350	COG0343	queuine tRNA-ribosyltransferase activity
I6I48_RS30360	COG3077	Addiction module antitoxin, RelB DinJ family
I6I48_RS30365	COG1862	Preprotein translocase
I6I48_RS30370	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I48_RS30375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I48_RS30395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I48_RS30405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I48_RS30410	COG1702	phosphate starvation-inducible protein PhoH
I6I48_RS30415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I48_RS30420	COG4535	Mg2 and Co2 transporter CorC
I6I48_RS30425	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I48_RS30430	COG0667	Aldo Keto reductase
I6I48_RS30475	COG0697	spore germination
I6I48_RS30485	COG0678	peroxiredoxin activity
I6I48_RS30495	COG0412	Dienelactone hydrolase
I6I48_RS30505	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I48_RS30515	COG0314	molybdopterin synthase activity
I6I48_RS30520	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I48_RS30525	COG0303	'Molybdopterin
I6I48_RS30535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I48_RS30555	COG3383	formate dehydrogenase (NAD+) activity
I6I48_RS30560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I48_RS30570	COG2223	nitrite transmembrane transporter activity
I6I48_RS30595	COG0583	DNA-binding transcription factor activity
I6I48_RS30600	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I48_RS30635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I48_RS30650	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS30670	COG2828	Protein conserved in bacteria
I6I48_RS30675	COG0583	DNA-binding transcription factor activity
I6I48_RS30680	COG0456	acetyltransferase
I6I48_RS30720	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I48_RS30745	COG4774	siderophore transport
I6I48_RS30765	COG4585	Histidine kinase
I6I48_RS30775	COG0671	phosphoesterase, PA-phosphatase related
I6I48_RS30790	COG1666	GTP binding
I6I48_RS30795	COG1120	ATPase activity
I6I48_RS30800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I48_RS30805	COG4558	Periplasmic binding protein
I6I48_RS30810	COG3720	iron ion transport
I6I48_RS30820	COG3712	iron ion homeostasis
I6I48_RS30825	COG1595	DNA-templated transcription, initiation
I6I48_RS30840	COG2378	regulation of single-species biofilm formation
I6I48_RS30870	COG1113	amino acid transport
I6I48_RS30880	COG1522	sequence-specific DNA binding
I6I48_RS30885	COG1272	protein, Hemolysin III
I6I48_RS30890	COG3191	aminopeptidase activity
I6I48_RS30895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS30900	COG0765	amino acid transport
I6I48_RS30905	COG1126	abc transporter atp-binding protein
I6I48_RS30910	COG4942	peptidase
I6I48_RS30930	COG1999	signal sequence binding
I6I48_RS30950	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6I48_RS30960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I48_RS30965	COG1845	cytochrome c oxidase, subunit III
I6I48_RS30970	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I48_RS30990	COG4772	TonB-dependent receptor
I6I48_RS31010	COG0281	malic enzyme
I6I48_RS31010	COG0280	phosphate acetyltransferase
I6I48_RS31025	COG0697	spore germination
I6I48_RS31060	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS31070	COG0583	DNA-binding transcription factor activity
I6I48_RS31090	COG1396	sequence-specific DNA binding
I6I48_RS31095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I48_RS31120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6I48_RS31135	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6I48_RS31140	COG1285	pathogenesis
I6I48_RS31145	COG1028	Short-chain dehydrogenase reductase Sdr
I6I48_RS31150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I48_RS31165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I48_RS31180	COG3712	iron ion homeostasis
I6I48_RS31185	COG1595	DNA-templated transcription, initiation
I6I48_RS31195	COG4221	oxidoreductase activity
I6I48_RS31200	COG4773	Receptor
I6I48_RS31220	COG5001	Diguanylate cyclase
I6I48_RS31225	COG0330	HflC and HflK could
I6I48_RS31250	COG2807	transmembrane transport
I6I48_RS31255	COG2207	Transcriptional regulator
I6I48_RS31260	COG4106	trans-aconitate 2-methyltransferase activity
I6I48_RS31275	COG0583	DNA-binding transcription factor activity
I6I48_RS31305	COG3712	iron ion homeostasis
I6I48_RS31330	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6I48_RS31335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I48_RS31340	COG0477	Major facilitator Superfamily
I6I48_RS31345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I48_RS31350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I48_RS31355	COG1845	cytochrome c oxidase, subunit III
I6I48_RS31360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I48_RS31370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_RS31375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6I48_RS31385	COG2814	Major facilitator Superfamily
I6I48_RS31400	COG0625	glutathione transferase activity
I6I48_RS31460	COG3707	response regulator
I6I48_RS31465	COG2146	nitrite reductase [NAD(P)H] activity
I6I48_RS31465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I48_RS31470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I48_RS31470	COG2146	nitrite reductase [NAD(P)H] activity
I6I48_RS31475	COG0243	molybdopterin cofactor binding
I6I48_RS31485	COG0667	Aldo Keto reductase
I6I48_RS31500	COG0656	L-ascorbic acid biosynthetic process
I6I48_RS31505	COG0583	DNA-binding transcription factor activity
I6I48_RS31510	COG0023	Translation Initiation Factor
I6I48_RS31520	COG0456	acetyltransferase
I6I48_RS31520	COG0454	-acetyltransferase
I6I48_RS31525	COG0583	DNA-binding transcription factor activity
I6I48_RS31530	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_RS31555	COG0840	transmembrane signaling receptor activity
I6I48_RS31560	COG2199	diguanylate cyclase activity
I6I48_RS31560	COG2203	Gaf domain
I6I48_RS31565	COG0640	Transcriptional regulator
I6I48_RS31575	COG0740	serine-type endopeptidase activity
I6I48_RS31580	COG2814	Major facilitator Superfamily
I6I48_RS31610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_RS31620	COG0596	Alpha beta hydrolase
I6I48_RS31635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I48_RS31640	COG0583	DNA-binding transcription factor activity
I6I48_RS31675	COG0028	Belongs to the TPP enzyme family
I6I48_RS31695	COG1230	cation diffusion facilitator family transporter
I6I48_RS31715	COG1132	(ABC) transporter
I6I48_RS31725	COG1201	RNA secondary structure unwinding
I6I48_RS31730	COG1793	dna ligase
I6I48_RS31735	COG1793	dna ligase
I6I48_RS31735	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6I48_RS31775	COG1960	acyl-CoA dehydrogenase activity
I6I48_RS31785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I48_RS31790	COG0697	spore germination
I6I48_RS31810	COG0436	Aminotransferase
I6I48_RS31815	COG0583	DNA-binding transcription factor activity
I6I48_RS31820	COG0583	DNA-binding transcription factor activity
I6I48_RS31845	COG0583	DNA-binding transcription factor activity
I6I48_RS31850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I48_RS31855	COG3181	Tripartite tricarboxylate transporter family receptor
I6I48_RS31860	COG4948	Mandelate Racemase Muconate Lactonizing
I6I48_RS31875	COG0318	PFAM AMP-dependent synthetase and ligase
I6I48_RS31920	COG1595	DNA-templated transcription, initiation
I6I48_RS31935	COG0583	DNA-binding transcription factor activity
I6I48_RS31940	COG1902	pentaerythritol trinitrate reductase activity
I6I48_RS31950	COG0251	oxidation-reduction process
I6I48_RS31970	COG4172	Belongs to the ABC transporter superfamily
I6I48_RS31995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I48_RS32010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS32045	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6I48_RS32050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I48_RS32070	COG2433	Pfam Transposase IS66
I6I48_RS32095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I48_RS32100	COG0459	protein refolding
I6I48_RS32110	COG1846	Transcriptional regulator
I6I48_RS32130	COG1917	Cupin 2, conserved barrel domain protein
I6I48_RS32155	COG1137	ATPase activity
I6I48_RS32165	COG0246	Mannitol dehydrogenase
I6I48_RS32170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I48_RS32175	COG1252	NADH dehydrogenase
I6I48_RS32180	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I48_RS32185	COG1546	Belongs to the CinA family
I6I48_RS32215	COG1280	lysine exporter protein (LysE YggA)