locus-tag	class	description
I6G72_RS00020	COG0789	Transcriptional regulator
I6G72_RS00060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G72_RS00070	COG0789	Transcriptional regulator
I6G72_RS00085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G72_RS00090	COG0629	single-stranded DNA binding
I6G72_RS00180	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6G72_RS00185	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6G72_RS00190	COG0167	dihydroorotate dehydrogenase activity
I6G72_RS00205	COG1414	Transcriptional regulator
I6G72_RS00210	COG1058	Belongs to the CinA family
I6G72_RS00210	COG1546	Belongs to the CinA family
I6G72_RS00225	COG0513	Belongs to the DEAD box helicase family
I6G72_RS00235	COG4771	TonB-dependent receptor
I6G72_RS00240	COG2814	Major facilitator Superfamily
I6G72_RS00280	COG4783	chaperone-mediated protein folding
I6G72_RS00295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G72_RS00300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G72_RS00315	COG0006	proline dipeptidase activity
I6G72_RS00325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G72_RS00350	COG0632	four-way junction helicase activity
I6G72_RS00355	COG1090	epimerase
I6G72_RS00365	COG2255	four-way junction helicase activity
I6G72_RS00370	COG4191	Histidine kinase
I6G72_RS00385	COG0514	ATP-dependent DNA helicase (RecQ)
I6G72_RS00390	COG1294	oxidase, subunit
I6G72_RS00400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G72_RS00405	COG0850	regulation of cytokinetic process
I6G72_RS00410	COG2894	cell division
I6G72_RS00415	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6G72_RS00440	COG0488	(ABC) transporter
I6G72_RS00445	COG2746	aminoglycoside 3-N-acetyltransferase activity
I6G72_RS00465	COG4608	Belongs to the ABC transporter superfamily
I6G72_RS00470	COG0444	Belongs to the ABC transporter superfamily
I6G72_RS00475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS00480	COG0601	transmembrane transport
I6G72_RS00485	COG0747	negative chemotaxis
I6G72_RS00510	COG4638	Rieske (2fe-2S)
I6G72_RS00515	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6G72_RS00535	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6G72_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS00565	COG0463	Glycosyl transferase, family 2
I6G72_RS00565	COG1216	Glycosyl transferase, family 2
I6G72_RS00580	COG0800	Aldolase
I6G72_RS00590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G72_RS00630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G72_RS00635	COG1566	PFAM secretion protein HlyD family protein
I6G72_RS00645	COG0577	efflux transmembrane transporter activity
I6G72_RS00645	COG1136	(ABC) transporter
I6G72_RS00675	COG1136	(ABC) transporter
I6G72_RS00675	COG0577	efflux transmembrane transporter activity
I6G72_RS00695	COG0583	DNA-binding transcription factor activity
I6G72_RS00700	COG1538	Outer membrane efflux protein
I6G72_RS00705	COG1136	(ABC) transporter
I6G72_RS00705	COG0577	efflux transmembrane transporter activity
I6G72_RS00710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G72_RS00725	COG0259	pyridoxamine-phosphate oxidase activity
I6G72_RS00735	COG0579	oxidoreductase
I6G72_RS00745	COG0583	DNA-binding transcription factor activity
I6G72_RS00755	COG2175	clavaminate synthase activity
I6G72_RS00765	COG1304	FMN binding
I6G72_RS00775	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G72_RS00780	COG0583	DNA-binding transcription factor activity
I6G72_RS00785	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS00795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G72_RS00800	COG0531	amino acid
I6G72_RS00815	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS00825	COG0114	fumarate hydratase activity
I6G72_RS00830	COG0802	atpase or kinase
I6G72_RS00835	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G72_RS00845	COG0586	Pfam SNARE associated Golgi protein
I6G72_RS00850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G72_RS00855	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G72_RS00865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G72_RS00880	COG0617	tRNA 3'-terminal CCA addition
I6G72_RS00890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G72_RS00895	COG2301	Belongs to the HpcH HpaI aldolase family
I6G72_RS00905	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6G72_RS00915	COG1024	Enoyl-CoA hydratase
I6G72_RS00925	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS00935	COG0183	Belongs to the thiolase family
I6G72_RS00940	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS00950	COG2070	2-Nitropropane dioxygenase
I6G72_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS00970	COG2030	dehydratase
I6G72_RS00975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G72_RS00995	COG1024	Enoyl-CoA hydratase
I6G72_RS01000	COG0752	glycyl-tRNA synthetase alpha subunit
I6G72_RS01005	COG0751	glycine-tRNA ligase activity
I6G72_RS01010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G72_RS01015	COG0204	Acyl-transferase
I6G72_RS01035	COG0242	peptide deformylase activity
I6G72_RS01040	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS01045	COG0700	Nucleoside recognition
I6G72_RS01050	COG0469	pyruvate kinase activity
I6G72_RS01055	COG1929	Belongs to the glycerate kinase type-1 family
I6G72_RS01060	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G72_RS01065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G72_RS01075	COG3178	'Phosphotransferase
I6G72_RS01090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G72_RS01105	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6G72_RS01140	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS01155	COG2982	Protein involved in outer membrane biogenesis
I6G72_RS01160	COG1368	sulfuric ester hydrolase activity
I6G72_RS01165	COG2818	Glycosylase
I6G72_RS01190	COG0735	belongs to the Fur family
I6G72_RS01200	COG0583	DNA-binding transcription factor activity
I6G72_RS01205	COG0840	transmembrane signaling receptor activity
I6G72_RS01225	COG3712	iron ion homeostasis
I6G72_RS01230	COG1595	DNA-templated transcription, initiation
I6G72_RS01245	COG2011	ABC-type metal ion transport system permease component
I6G72_RS01250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G72_RS01255	COG1501	Belongs to the glycosyl hydrolase 31 family
I6G72_RS01260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G72_RS01260	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6G72_RS01265	COG0483	inositol monophosphate 1-phosphatase activity
I6G72_RS01270	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS01275	COG1473	amidohydrolase
I6G72_RS01280	COG0583	DNA-binding transcription factor activity
I6G72_RS01285	COG2855	membrane
I6G72_RS01295	COG2239	Acts as a magnesium transporter
I6G72_RS01310	COG1522	sequence-specific DNA binding
I6G72_RS01315	COG0300	oxidoreductase activity
I6G72_RS01325	COG0028	Belongs to the TPP enzyme family
I6G72_RS01345	COG0653	protein targeting
I6G72_RS01350	COG0739	heme binding
I6G72_RS01360	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6G72_RS01365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G72_RS01375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G72_RS01380	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G72_RS01385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G72_RS01390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G72_RS01400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G72_RS01405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G72_RS01410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G72_RS01420	COG3116	cell division
I6G72_RS01425	COG0275	rRNA processing
I6G72_RS01430	COG2001	Belongs to the MraZ family
I6G72_RS01440	COG0488	(ABC) transporter
I6G72_RS01445	COG0418	dihydroorotase activity
I6G72_RS01450	COG1473	amidohydrolase
I6G72_RS01460	COG0583	DNA-binding transcription factor activity
I6G72_RS01500	COG1522	sequence-specific DNA binding
I6G72_RS01510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G72_RS01515	COG4654	Cytochrome c, class I
I6G72_RS01520	COG0129	dihydroxy-acid dehydratase activity
I6G72_RS01560	COG0405	Gamma-glutamyltransferase
I6G72_RS01565	COG2084	Dehydrogenase
I6G72_RS01580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G72_RS01610	COG0442	prolyl-tRNA aminoacylation
I6G72_RS01615	COG0824	Thioesterase
I6G72_RS01620	COG0811	peptide transport
I6G72_RS01625	COG0848	biopolymer transport protein
I6G72_RS01635	COG0823	Involved in the tonB-independent uptake of proteins
I6G72_RS01650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G72_RS01655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6G72_RS01670	COG1522	sequence-specific DNA binding
I6G72_RS01680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G72_RS01695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS01700	COG0697	spore germination
I6G72_RS01710	COG1346	cytolysis
I6G72_RS01720	COG0583	DNA-binding transcription factor activity
I6G72_RS01730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G72_RS01750	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G72_RS01770	COG0583	DNA-binding transcription factor activity
I6G72_RS01785	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6G72_RS01790	COG0463	Glycosyl transferase, family 2
I6G72_RS01800	COG0786	glutamate:sodium symporter activity
I6G72_RS01815	COG1671	Belongs to the UPF0178 family
I6G72_RS01830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G72_RS01835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G72_RS01845	COG0328	RNA-DNA hybrid ribonuclease activity
I6G72_RS01850	COG2226	methyltransferase
I6G72_RS01855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G72_RS01860	COG1388	LysM domain
I6G72_RS01860	COG0741	lytic transglycosylase activity
I6G72_RS01900	COG1366	Belongs to the anti-sigma-factor antagonist family
I6G72_RS01905	COG2172	sigma factor antagonist activity
I6G72_RS01910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G72_RS01920	COG2770	Histidine kinase
I6G72_RS01920	COG2208	phosphoserine phosphatase activity
I6G72_RS01940	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS01950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G72_RS01960	COG1942	4-Oxalocrotonate Tautomerase
I6G72_RS01965	COG0583	DNA-binding transcription factor activity
I6G72_RS01975	COG2719	SpoVR family
I6G72_RS01980	COG2718	Belongs to the UPF0229 family
I6G72_RS01985	COG2766	serine protein kinase
I6G72_RS02000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G72_RS02000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G72_RS02015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6G72_RS02020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6G72_RS02035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G72_RS02050	COG0316	Belongs to the HesB IscA family
I6G72_RS02060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G72_RS02065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G72_RS02070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G72_RS02085	COG4177	L-phenylalanine transmembrane transporter activity
I6G72_RS02100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6G72_RS02105	COG0312	modulator of DNA gyrase
I6G72_RS02110	COG3028	Belongs to the UPF0307 family
I6G72_RS02125	COG1116	anion transmembrane transporter activity
I6G72_RS02130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS02135	COG1335	isochorismatase
I6G72_RS02140	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G72_RS02140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G72_RS02140	COG1042	CoA-binding domain protein
I6G72_RS02145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G72_RS02160	COG0583	DNA-binding transcription factor activity
I6G72_RS02170	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS02175	COG1522	sequence-specific DNA binding
I6G72_RS02210	COG1696	Membrane protein involved in D-alanine export
I6G72_RS02235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G72_RS02235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G72_RS02245	COG2264	protein methyltransferase activity
I6G72_RS02250	COG0439	Biotin carboxylase
I6G72_RS02255	COG0511	ligase activity, forming carbon-carbon bonds
I6G72_RS02260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6G72_RS02265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G72_RS02270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G72_RS02275	COG3150	esterase
I6G72_RS02280	COG0557	exoribonuclease II activity
I6G72_RS02300	COG1175	transmembrane transport
I6G72_RS02305	COG3842	ATPase activity
I6G72_RS02315	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G72_RS02320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G72_RS02330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G72_RS02335	COG1126	abc transporter atp-binding protein
I6G72_RS02340	COG0765	amino acid transport
I6G72_RS02350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS02355	COG0436	Aminotransferase
I6G72_RS02360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G72_RS02385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6G72_RS02390	COG1678	Uncharacterized ACR, COG1678
I6G72_RS02405	COG0352	thiamine-phosphate diphosphorylase activity
I6G72_RS02410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G72_RS02415	COG0741	lytic transglycosylase activity
I6G72_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS02430	COG1335	isochorismatase
I6G72_RS02435	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6G72_RS02440	COG4638	Rieske (2fe-2S)
I6G72_RS02480	COG1024	Enoyl-CoA hydratase
I6G72_RS02485	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS02520	COG0410	ABC transporter
I6G72_RS02555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6G72_RS02575	COG3842	ATPase activity
I6G72_RS02580	COG1175	transmembrane transport
I6G72_RS02585	COG3833	ABC-type maltose transport systems, permease component
I6G72_RS02600	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6G72_RS02605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G72_RS02635	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6G72_RS02640	COG0237	dephospho-CoA kinase activity
I6G72_RS02660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G72_RS02665	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6G72_RS02675	COG0477	Major facilitator Superfamily
I6G72_RS02710	COG1605	Chorismate mutase
I6G72_RS02710	COG0077	Prephenate dehydratase
I6G72_RS02720	COG2081	HI0933 family
I6G72_RS02725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G72_RS02740	COG4177	L-phenylalanine transmembrane transporter activity
I6G72_RS02745	COG1129	ABC transporter
I6G72_RS02770	COG1126	abc transporter atp-binding protein
I6G72_RS02775	COG0765	amino acid transport
I6G72_RS02780	COG4597	amino acid ABC transporter
I6G72_RS02785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS02790	COG2884	Cell division ATP-binding protein ftsE
I6G72_RS02795	COG2177	Part of the ABC transporter FtsEX involved in
I6G72_RS02820	COG1194	a g-specific adenine glycosylase
I6G72_RS02835	COG0246	Mannitol dehydrogenase
I6G72_RS02840	COG4948	Mandelate Racemase Muconate Lactonizing
I6G72_RS02845	COG1126	abc transporter atp-binding protein
I6G72_RS02850	COG0765	amino acid transport
I6G72_RS02860	COG1063	alcohol dehydrogenase
I6G72_RS02875	COG2186	Transcriptional regulator
I6G72_RS02885	COG4771	TonB-dependent receptor
I6G72_RS02890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G72_RS02895	COG2022	thiamine diphosphate biosynthetic process
I6G72_RS02900	COG0351	phosphomethylpyrimidine kinase
I6G72_RS02905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6G72_RS02915	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G72_RS02925	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G72_RS02940	COG2226	methyltransferase
I6G72_RS02945	COG0745	RESPONSE REGULATOR receiver
I6G72_RS02970	COG2132	Multicopper oxidase
I6G72_RS02985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G72_RS02995	COG0583	DNA-binding transcription factor activity
I6G72_RS03005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G72_RS03010	COG1984	allophanate hydrolase subunit 2
I6G72_RS03020	COG1802	Transcriptional regulator
I6G72_RS03025	COG2860	membrane
I6G72_RS03035	COG2223	nitrite transmembrane transporter activity
I6G72_RS03040	COG2813	Specifically methylates the guanine in position
I6G72_RS03040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G72_RS03045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G72_RS03050	COG2188	Transcriptional regulator
I6G72_RS03055	COG2721	sulfolactate sulfo-lyase activity
I6G72_RS03060	COG2721	sulfolactate sulfo-lyase activity
I6G72_RS03070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G72_RS03075	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G72_RS03105	COG2918	glutathione biosynthetic process
I6G72_RS03115	COG2988	succinylglutamate desuccinylase activity
I6G72_RS03125	COG0583	DNA-binding transcription factor activity
I6G72_RS03135	COG1802	Transcriptional regulator
I6G72_RS03150	COG1129	ABC transporter
I6G72_RS03170	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G72_RS03185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G72_RS03190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G72_RS03195	COG1595	DNA-templated transcription, initiation
I6G72_RS03205	COG0583	DNA-binding transcription factor activity
I6G72_RS03210	COG1764	response to oxidative stress
I6G72_RS03225	COG2814	Major facilitator Superfamily
I6G72_RS03240	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G72_RS03255	COG1309	transcriptional regulator
I6G72_RS03265	COG1024	Enoyl-CoA hydratase
I6G72_RS03270	COG1024	Enoyl-CoA hydratase
I6G72_RS03275	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G72_RS03285	COG0747	negative chemotaxis
I6G72_RS03290	COG0583	DNA-binding transcription factor activity
I6G72_RS03300	COG2988	succinylglutamate desuccinylase activity
I6G72_RS03305	COG0747	negative chemotaxis
I6G72_RS03310	COG0601	transmembrane transport
I6G72_RS03320	COG0444	Belongs to the ABC transporter superfamily
I6G72_RS03325	COG4608	Belongs to the ABC transporter superfamily
I6G72_RS03335	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G72_RS03345	COG2171	N-acyltransferase activity
I6G72_RS03355	COG4221	oxidoreductase activity
I6G72_RS03360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G72_RS03375	COG0210	DNA helicase
I6G72_RS03380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G72_RS03385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6G72_RS03395	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6G72_RS03405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G72_RS03410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6G72_RS03415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G72_RS03430	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G72_RS03445	COG1024	Enoyl-CoA hydratase
I6G72_RS03450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G72_RS03460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G72_RS03475	COG0583	DNA-binding transcription factor activity
I6G72_RS03480	COG3473	Maleate cis-trans isomerase
I6G72_RS03505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G72_RS03520	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G72_RS03525	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G72_RS03555	COG0037	tRNA processing
I6G72_RS03565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G72_RS03570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G72_RS03580	COG2967	ApaG domain
I6G72_RS03585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G72_RS03590	COG0546	phosphoglycolate phosphatase activity
I6G72_RS03600	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G72_RS03605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G72_RS03610	COG0134	indole-3-glycerol-phosphate synthase activity
I6G72_RS03615	COG3284	Transcriptional regulator
I6G72_RS03620	COG1012	belongs to the aldehyde dehydrogenase family
I6G72_RS03655	COG0709	Synthesizes selenophosphate from selenide and ATP
I6G72_RS03660	COG1305	Transglutaminase-like
I6G72_RS03665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G72_RS03670	COG1216	Glycosyl transferase, family 2
I6G72_RS03680	COG3276	selenocysteine insertion sequence binding
I6G72_RS03695	COG2864	formate dehydrogenase
I6G72_RS03700	COG0437	4 iron, 4 sulfur cluster binding
I6G72_RS03715	COG1607	acyl-coa hydrolase
I6G72_RS03740	COG3064	Membrane
I6G72_RS03745	COG3585	molybdate ion transport
I6G72_RS03750	COG1116	anion transmembrane transporter activity
I6G72_RS03755	COG1464	Belongs to the NlpA lipoprotein family
I6G72_RS03760	COG2011	ABC-type metal ion transport system permease component
I6G72_RS03775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS03780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G72_RS03785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G72_RS03790	COG0431	NADPH-dependent FMN reductase
I6G72_RS03795	COG1464	Belongs to the NlpA lipoprotein family
I6G72_RS03820	COG0747	negative chemotaxis
I6G72_RS03830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS03860	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G72_RS03870	COG1802	Transcriptional regulator
I6G72_RS03930	COG3188	usher protein
I6G72_RS03945	COG2814	Major facilitator Superfamily
I6G72_RS03950	COG0840	transmembrane signaling receptor activity
I6G72_RS03965	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6G72_RS03970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6G72_RS03980	COG2188	Transcriptional regulator
I6G72_RS03995	COG0737	Belongs to the 5'-nucleotidase family
I6G72_RS04045	COG0463	Glycosyl transferase, family 2
I6G72_RS04050	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6G72_RS04060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G72_RS04070	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6G72_RS04075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6G72_RS04080	COG2423	ornithine cyclodeaminase activity
I6G72_RS04090	COG0583	DNA-binding transcription factor activity
I6G72_RS04095	COG2814	Major facilitator Superfamily
I6G72_RS04100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6G72_RS04105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6G72_RS04130	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6G72_RS04145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G72_RS04150	COG1120	ATPase activity
I6G72_RS04155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G72_RS04160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G72_RS04165	COG4592	Periplasmic binding protein
I6G72_RS04170	COG4774	siderophore transport
I6G72_RS04185	COG2814	Major facilitator Superfamily
I6G72_RS04195	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6G72_RS04215	COG0438	transferase activity, transferring glycosyl groups
I6G72_RS04225	COG2814	Major facilitator Superfamily
I6G72_RS04230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G72_RS04250	COG1999	signal sequence binding
I6G72_RS04260	COG1612	heme a metabolic process
I6G72_RS04280	COG1845	cytochrome c oxidase, subunit III
I6G72_RS04290	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G72_RS04310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G72_RS04335	COG0067	glutamate synthase
I6G72_RS04335	COG0069	glutamate synthase activity
I6G72_RS04335	COG0070	glutamate synthase
I6G72_RS04350	COG1984	allophanate hydrolase subunit 2
I6G72_RS04365	COG0511	ligase activity, forming carbon-carbon bonds
I6G72_RS04370	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6G72_RS04375	COG0583	DNA-binding transcription factor activity
I6G72_RS04390	COG0477	Major facilitator Superfamily
I6G72_RS04400	COG2070	2-Nitropropane dioxygenase
I6G72_RS04405	COG1127	ABC transporter
I6G72_RS04410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G72_RS04415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G72_RS04420	COG2853	Lipoprotein
I6G72_RS04430	COG1131	(ABC) transporter
I6G72_RS04435	COG0842	Transport permease protein
I6G72_RS04445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G72_RS04450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G72_RS04455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G72_RS04460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G72_RS04465	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G72_RS04470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G72_RS04475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6G72_RS04480	COG0107	imidazoleglycerol-phosphate synthase activity
I6G72_RS04485	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G72_RS04490	COG0140	phosphoribosyl-ATP diphosphatase activity
I6G72_RS04495	COG0537	adenosine 5'-monophosphoramidase activity
I6G72_RS04500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G72_RS04520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G72_RS04525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G72_RS04530	COG1970	mechanosensitive ion channel activity
I6G72_RS04535	COG0723	plastoquinol--plastocyanin reductase activity
I6G72_RS04540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G72_RS04545	COG2857	Cytochrome c1
I6G72_RS04550	COG0625	glutathione transferase activity
I6G72_RS04555	COG2969	positive regulation of protein catabolic process
I6G72_RS04585	COG0583	DNA-binding transcription factor activity
I6G72_RS04595	COG1104	cysteine desulfurase activity
I6G72_RS04605	COG3708	Transcriptional regulator
I6G72_RS04605	COG2207	Transcriptional regulator
I6G72_RS04615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G72_RS04620	COG0747	negative chemotaxis
I6G72_RS04625	COG0601	transmembrane transport
I6G72_RS04630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS04640	COG1228	amidohydrolase
I6G72_RS04645	COG5339	Protein conserved in bacteria
I6G72_RS04650	COG5339	Protein conserved in bacteria
I6G72_RS04655	COG0513	Belongs to the DEAD box helicase family
I6G72_RS04660	COG1280	lysine exporter protein (LysE YggA)
I6G72_RS04665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G72_RS04685	COG0583	DNA-binding transcription factor activity
I6G72_RS04705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G72_RS04720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G72_RS04730	COG1609	Transcriptional regulator
I6G72_RS04735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G72_RS04745	COG1653	transport
I6G72_RS04750	COG1175	transmembrane transport
I6G72_RS04755	COG0395	ABC-type sugar transport system, permease component
I6G72_RS04770	COG0018	arginyl-trna synthetase
I6G72_RS04780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G72_RS04805	COG1280	lysine exporter protein (LysE YggA)
I6G72_RS04820	COG1742	UPF0060 membrane protein
I6G72_RS04830	COG1473	amidohydrolase
I6G72_RS04835	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS04840	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6G72_RS04845	COG0183	Belongs to the thiolase family
I6G72_RS04850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G72_RS04900	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS04915	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS04920	COG1595	DNA-templated transcription, initiation
I6G72_RS04935	COG2814	Major facilitator Superfamily
I6G72_RS04940	COG2186	Transcriptional regulator
I6G72_RS04970	COG3339	Conserved Protein
I6G72_RS04980	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6G72_RS04990	COG2814	Major facilitator Superfamily
I6G72_RS05015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G72_RS05020	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS05025	COG3422	double-strand break repair
I6G72_RS05030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS05035	COG0765	amino acid transport
I6G72_RS05040	COG0765	amino acid transport
I6G72_RS05060	COG2358	TRAP transporter, solute receptor (TAXI family
I6G72_RS05070	COG2922	Belongs to the Smg family
I6G72_RS05075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G72_RS05100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS05110	COG0028	Belongs to the TPP enzyme family
I6G72_RS05115	COG1522	sequence-specific DNA binding
I6G72_RS05120	COG3781	membrane
I6G72_RS05135	COG2814	Major facilitator Superfamily
I6G72_RS05150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G72_RS05165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G72_RS05175	COG1744	ABC transporter substrate-binding protein PnrA-like
I6G72_RS05180	COG3845	ABC transporter
I6G72_RS05185	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6G72_RS05195	COG0402	S-adenosylhomocysteine deaminase activity
I6G72_RS05200	COG0251	oxidation-reduction process
I6G72_RS05225	COG1177	transmembrane transport
I6G72_RS05230	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G72_RS05235	COG3842	ATPase activity
I6G72_RS05245	COG1609	Transcriptional regulator
I6G72_RS05300	COG1177	transmembrane transport
I6G72_RS05305	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G72_RS05310	COG3842	ATPase activity
I6G72_RS05345	COG1126	abc transporter atp-binding protein
I6G72_RS05350	COG0765	amino acid transport
I6G72_RS05355	COG0765	amino acid transport
I6G72_RS05360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS05365	COG0583	DNA-binding transcription factor activity
I6G72_RS05375	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6G72_RS05400	COG0583	DNA-binding transcription factor activity
I6G72_RS05405	COG0583	DNA-binding transcription factor activity
I6G72_RS05410	COG2814	Major facilitator Superfamily
I6G72_RS05420	COG0592	DNA-directed DNA polymerase activity
I6G72_RS05425	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G72_RS05430	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G72_RS05435	COG0594	ribonuclease P activity
I6G72_RS05440	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G72_RS05450	COG0753	catalase activity
I6G72_RS05455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G72_RS05465	COG2175	clavaminate synthase activity
I6G72_RS05470	COG1473	amidohydrolase
I6G72_RS05475	COG4608	Belongs to the ABC transporter superfamily
I6G72_RS05480	COG0444	Belongs to the ABC transporter superfamily
I6G72_RS05485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS05490	COG0601	transmembrane transport
I6G72_RS05500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6G72_RS05515	COG0038	chloride channel
I6G72_RS05545	COG0436	Aminotransferase
I6G72_RS05550	COG3180	Ammonia monooxygenase
I6G72_RS05555	COG1278	Cold shock
I6G72_RS05560	COG0445	tRNA wobble uridine modification
I6G72_RS05565	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G72_RS05570	COG1192	Involved in chromosome partitioning
I6G72_RS05580	COG1475	DNA binding
I6G72_RS05585	COG0252	asparaginase activity
I6G72_RS05590	COG0583	DNA-binding transcription factor activity
I6G72_RS05615	COG1349	DNA-binding transcription factor activity
I6G72_RS05625	COG3842	ATPase activity
I6G72_RS05630	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G72_RS05670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G72_RS05680	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G72_RS05690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G72_RS05695	COG0081	regulation of translation
I6G72_RS05700	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G72_RS05705	COG0222	ribosome binding
I6G72_RS05710	COG0085	RNA polymerase activity
I6G72_RS05715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G72_RS05730	COG5002	protein histidine kinase activity
I6G72_RS05745	COG0745	RESPONSE REGULATOR receiver
I6G72_RS05750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G72_RS05755	COG0049	tRNA binding
I6G72_RS05760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G72_RS05765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G72_RS05770	COG0051	transcription antitermination factor activity, RNA binding
I6G72_RS05775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G72_RS05785	COG0089	rRNA binding
I6G72_RS05790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G72_RS05795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G72_RS05800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G72_RS05805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6G72_RS05810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G72_RS05815	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G72_RS05820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G72_RS05840	COG4177	L-phenylalanine transmembrane transporter activity
I6G72_RS05860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G72_RS05875	COG2169	Transcriptional regulator
I6G72_RS05875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G72_RS05890	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G72_RS05895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G72_RS05900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G72_RS05905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G72_RS05910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G72_RS05915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G72_RS05920	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6G72_RS05925	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G72_RS05930	COG1841	ribosomal large subunit assembly
I6G72_RS05935	COG0200	Binds to the 23S rRNA
I6G72_RS05940	COG0201	protein transport
I6G72_RS05945	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G72_RS05950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G72_RS05955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G72_RS05960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G72_RS05965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G72_RS05970	COG0202	RNA polymerase activity
I6G72_RS05975	COG0203	ribosomal protein L17
I6G72_RS05985	COG1324	tolerance protein
I6G72_RS05990	COG4232	protein-disulfide reductase activity
I6G72_RS06005	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6G72_RS06015	COG1333	cytochrome c biogenesis protein
I6G72_RS06020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G72_RS06025	COG0019	diaminopimelate decarboxylase activity
I6G72_RS06035	COG1965	Belongs to the frataxin family
I6G72_RS06045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G72_RS06050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6G72_RS06055	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6G72_RS06060	COG0625	glutathione transferase activity
I6G72_RS06070	COG2814	Major facilitator Superfamily
I6G72_RS06080	COG4106	trans-aconitate 2-methyltransferase activity
I6G72_RS06120	COG2186	Transcriptional regulator
I6G72_RS06135	COG1422	Protein of unknown function (DUF1090)
I6G72_RS06145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS06150	COG1956	GAF domain-containing protein
I6G72_RS06155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G72_RS06170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G72_RS06195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G72_RS06200	COG3568	Endonuclease Exonuclease Phosphatase
I6G72_RS06225	COG0697	spore germination
I6G72_RS06230	COG2814	Major facilitator Superfamily
I6G72_RS06245	COG0367	asparagine synthase
I6G72_RS06260	COG2226	methyltransferase
I6G72_RS06290	COG0175	sulfate reduction
I6G72_RS06305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G72_RS06315	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G72_RS06325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G72_RS06340	COG0367	asparagine synthase
I6G72_RS06375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G72_RS06400	COG0859	PFAM glycosyl transferase family 9
I6G72_RS06415	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6G72_RS06425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G72_RS06450	COG1686	Belongs to the peptidase S11 family
I6G72_RS06460	COG2921	Belongs to the UPF0250 family
I6G72_RS06465	COG0321	lipoyl(octanoyl) transferase activity
I6G72_RS06480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6G72_RS06485	COG2096	Adenosyltransferase
I6G72_RS06495	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6G72_RS06500	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6G72_RS06510	COG0523	cobalamin synthesis protein
I6G72_RS06515	COG0735	belongs to the Fur family
I6G72_RS06530	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6G72_RS06540	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6G72_RS06545	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6G72_RS06555	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6G72_RS06570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G72_RS06575	COG0154	amidase activity
I6G72_RS06580	COG0477	Major facilitator Superfamily
I6G72_RS06590	COG0583	DNA-binding transcription factor activity
I6G72_RS06605	COG0066	3-isopropylmalate dehydratase activity
I6G72_RS06620	COG0438	transferase activity, transferring glycosyl groups
I6G72_RS06625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6G72_RS06630	COG1950	PFAM Membrane protein of
I6G72_RS06650	COG1305	Transglutaminase-like
I6G72_RS06660	COG2308	Evidence 4 Homologs of previously reported genes of
I6G72_RS06665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G72_RS06675	COG0617	tRNA 3'-terminal CCA addition
I6G72_RS06685	COG0513	Belongs to the DEAD box helicase family
I6G72_RS06690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G72_RS06760	COG0443	Heat shock 70 kDa protein
I6G72_RS06770	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6G72_RS06770	COG0352	thiamine-phosphate diphosphorylase activity
I6G72_RS06770	COG0351	phosphomethylpyrimidine kinase
I6G72_RS06775	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS06795	COG3189	MarR family transcriptional regulator
I6G72_RS06825	COG0640	Transcriptional regulator
I6G72_RS06885	COG1846	Transcriptional regulator
I6G72_RS06890	COG1764	response to oxidative stress
I6G72_RS06915	COG0583	DNA-binding transcription factor activity
I6G72_RS06925	COG0583	DNA-binding transcription factor activity
I6G72_RS06935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G72_RS06940	COG0708	Exodeoxyribonuclease III
I6G72_RS06945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G72_RS06960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G72_RS06965	COG0154	amidase activity
I6G72_RS06970	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G72_RS06975	COG1077	Cell shape determining protein MreB Mrl
I6G72_RS06980	COG1792	Involved in formation and maintenance of cell shape
I6G72_RS06990	COG0768	penicillin binding
I6G72_RS06995	COG0772	Belongs to the SEDS family
I6G72_RS07000	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G72_RS07005	COG0471	metal ion transport
I6G72_RS07010	COG1309	transcriptional regulator
I6G72_RS07020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G72_RS07025	COG1464	Belongs to the NlpA lipoprotein family
I6G72_RS07030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G72_RS07040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G72_RS07045	COG0792	nuclease activity
I6G72_RS07055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G72_RS07065	COG1660	Displays ATPase and GTPase activities
I6G72_RS07080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS07085	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6G72_RS07095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G72_RS07100	COG1137	ATPase activity
I6G72_RS07115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G72_RS07125	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6G72_RS07140	COG1294	oxidase, subunit
I6G72_RS07150	COG4988	ABC transporter
I6G72_RS07155	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6G72_RS07160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G72_RS07175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G72_RS07180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G72_RS07185	COG1238	metal cluster binding
I6G72_RS07200	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS07205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G72_RS07210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS07215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS07230	COG0758	DNA mediated transformation
I6G72_RS07235	COG0242	peptide deformylase activity
I6G72_RS07240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G72_RS07250	COG0546	phosphoglycolate phosphatase activity
I6G72_RS07270	COG1733	regulation of RNA biosynthetic process
I6G72_RS07280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G72_RS07285	COG1280	lysine exporter protein (LysE YggA)
I6G72_RS07290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G72_RS07290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G72_RS07300	COG5000	phosphorelay sensor kinase activity
I6G72_RS07305	COG2204	response regulator
I6G72_RS07310	COG0569	domain protein
I6G72_RS07315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G72_RS07320	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6G72_RS07325	COG2226	methyltransferase
I6G72_RS07330	COG1040	competence protein
I6G72_RS07340	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS07345	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G72_RS07350	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6G72_RS07355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G72_RS07365	COG0588	phosphoglycerate mutase activity
I6G72_RS07370	COG4942	peptidase
I6G72_RS07375	COG0793	Belongs to the peptidase S41A family
I6G72_RS07380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G72_RS07385	COG5002	protein histidine kinase activity
I6G72_RS07385	COG3447	MASE1 domain protein
I6G72_RS07385	COG5001	Diguanylate cyclase
I6G72_RS07390	COG2186	Transcriptional regulator
I6G72_RS07400	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6G72_RS07405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G72_RS07420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G72_RS07425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6G72_RS07430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G72_RS07435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G72_RS07440	COG0142	geranyltranstransferase activity
I6G72_RS07450	COG0489	protein tyrosine kinase activity
I6G72_RS07505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G72_RS07505	COG0551	DNA topoisomerase type I activity
I6G72_RS07555	COG2433	Pfam Transposase IS66
I6G72_RS07580	COG0659	secondary active sulfate transmembrane transporter activity
I6G72_RS07585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G72_RS07600	COG0459	protein refolding
I6G72_RS07610	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G72_RS07625	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G72_RS07630	COG0659	secondary active sulfate transmembrane transporter activity
I6G72_RS07635	COG0589	response to stress
I6G72_RS07650	COG0438	transferase activity, transferring glycosyl groups
I6G72_RS07660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G72_RS07665	COG0785	Cytochrome C biogenesis protein
I6G72_RS07700	COG3220	belongs to the UPF0276 family
I6G72_RS07725	COG0789	Transcriptional regulator
I6G72_RS07735	COG2608	mercury ion transmembrane transporter activity
I6G72_RS07740	COG2608	mercury ion transmembrane transporter activity
I6G72_RS07745	COG0789	Transcriptional regulator
I6G72_RS07760	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G72_RS07765	COG4654	Cytochrome c, class I
I6G72_RS07785	COG4191	Histidine kinase
I6G72_RS07810	COG0431	NADPH-dependent FMN reductase
I6G72_RS07840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G72_RS07845	COG0573	inorganic phosphate transmembrane transporter activity
I6G72_RS07850	COG0581	inorganic phosphate transmembrane transporter activity
I6G72_RS07855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G72_RS07865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G72_RS07880	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G72_RS07885	COG3593	DNA synthesis involved in DNA repair
I6G72_RS07945	COG3133	Outer membrane lipoprotein
I6G72_RS07985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G72_RS08010	COG2948	multi-organism process
I6G72_RS08045	COG3451	type IV secretory pathway VirB4
I6G72_RS08165	COG0235	Class ii aldolase
I6G72_RS08170	COG3622	Belongs to the hyi family
I6G72_RS08175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G72_RS08180	COG2084	Dehydrogenase
I6G72_RS08185	COG3395	kinase activity
I6G72_RS08190	COG2186	Transcriptional regulator
I6G72_RS08195	COG0583	DNA-binding transcription factor activity
I6G72_RS08215	COG3622	Belongs to the hyi family
I6G72_RS08235	COG1522	sequence-specific DNA binding
I6G72_RS08240	COG1280	lysine exporter protein (LysE YggA)
I6G72_RS08255	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G72_RS08260	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G72_RS08265	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G72_RS08280	COG1464	Belongs to the NlpA lipoprotein family
I6G72_RS08300	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS08325	COG0477	Major facilitator Superfamily
I6G72_RS08330	COG0583	DNA-binding transcription factor activity
I6G72_RS08340	COG0583	DNA-binding transcription factor activity
I6G72_RS08355	COG0625	glutathione transferase activity
I6G72_RS08360	COG1053	succinate dehydrogenase
I6G72_RS08370	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS08390	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G72_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS08405	COG1802	Transcriptional regulator
I6G72_RS08410	COG0288	reversible hydration of carbon dioxide
I6G72_RS08430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G72_RS08440	COG4829	muconolactone delta-isomerase
I6G72_RS08445	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G72_RS08455	COG1414	Transcriptional regulator
I6G72_RS08460	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS08465	COG2031	fatty acid transporter
I6G72_RS08470	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G72_RS08475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6G72_RS08480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6G72_RS08485	COG2200	EAL domain
I6G72_RS08500	COG0583	DNA-binding transcription factor activity
I6G72_RS08505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G72_RS08515	COG0129	dihydroxy-acid dehydratase activity
I6G72_RS08520	COG0583	DNA-binding transcription factor activity
I6G72_RS08525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G72_RS08530	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G72_RS08540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G72_RS08545	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS08550	COG0410	ABC transporter
I6G72_RS08575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G72_RS08585	COG2186	Transcriptional regulator
I6G72_RS08595	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I6G72_RS08615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G72_RS08620	COG0583	DNA-binding transcription factor activity
I6G72_RS08625	COG0628	permease
I6G72_RS08645	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G72_RS08650	COG3842	ATPase activity
I6G72_RS08660	COG0277	FAD linked oxidase domain protein
I6G72_RS08675	COG0477	Major facilitator Superfamily
I6G72_RS08690	COG1695	Transcriptional regulator
I6G72_RS08700	COG0583	DNA-binding transcription factor activity
I6G72_RS08720	COG5002	protein histidine kinase activity
I6G72_RS08720	COG2198	Histidine kinase
I6G72_RS08720	COG0784	Response regulator, receiver
I6G72_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS08840	COG3246	L-lysine catabolic process to acetate
I6G72_RS08845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G72_RS08850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS08865	COG2233	PERMEase
I6G72_RS08875	COG0326	Molecular chaperone. Has ATPase activity
I6G72_RS08880	COG2814	Major facilitator Superfamily
I6G72_RS08885	COG4774	siderophore transport
I6G72_RS08900	COG1131	(ABC) transporter
I6G72_RS08905	COG2271	Major facilitator Superfamily
I6G72_RS08910	COG4948	Mandelate Racemase Muconate Lactonizing
I6G72_RS08915	COG0800	Aldolase
I6G72_RS08920	COG3734	2-keto-3-deoxy-galactonokinase
I6G72_RS08925	COG1414	Transcriptional regulator
I6G72_RS08945	COG3550	peptidyl-serine autophosphorylation
I6G72_RS08980	COG1012	belongs to the aldehyde dehydrogenase family
I6G72_RS09015	COG0625	glutathione transferase activity
I6G72_RS09030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G72_RS09035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G72_RS09040	COG1652	LysM domain
I6G72_RS09060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6G72_RS09065	COG0583	DNA-binding transcription factor activity
I6G72_RS09070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G72_RS09075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G72_RS09120	COG4948	Mandelate Racemase Muconate Lactonizing
I6G72_RS09125	COG0372	Belongs to the citrate synthase family
I6G72_RS09130	COG0154	amidase activity
I6G72_RS09135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G72_RS09140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G72_RS09155	COG3246	L-lysine catabolic process to acetate
I6G72_RS09160	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS09170	COG0477	Major facilitator Superfamily
I6G72_RS09200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G72_RS09210	COG2205	protein histidine kinase activity
I6G72_RS09215	COG0165	Argininosuccinate lyase
I6G72_RS09225	COG3712	iron ion homeostasis
I6G72_RS09230	COG1595	DNA-templated transcription, initiation
I6G72_RS09250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G72_RS09275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G72_RS09290	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6G72_RS09300	COG1234	tRNA 3'-trailer cleavage
I6G72_RS09310	COG0625	glutathione transferase activity
I6G72_RS09320	COG3258	Cytochrome c
I6G72_RS09355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS09365	COG1294	oxidase, subunit
I6G72_RS09370	COG1271	oxidase subunit
I6G72_RS09375	COG0697	spore germination
I6G72_RS09380	COG0583	DNA-binding transcription factor activity
I6G72_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS09395	COG0842	Transport permease protein
I6G72_RS09400	COG0842	Transport permease protein
I6G72_RS09400	COG1129	ABC transporter
I6G72_RS09405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G72_RS09425	COG2200	EAL domain
I6G72_RS09445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G72_RS09460	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6G72_RS09460	COG2755	lipolytic protein G-D-S-L family
I6G72_RS09475	COG1054	Belongs to the UPF0176 family
I6G72_RS09480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G72_RS09480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G72_RS09490	COG0489	protein tyrosine kinase activity
I6G72_RS09505	COG0717	Belongs to the dCTP deaminase family
I6G72_RS09515	COG3706	GGDEF domain
I6G72_RS09535	COG2081	HI0933 family
I6G72_RS09550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G72_RS09555	COG0509	glycine decarboxylation via glycine cleavage system
I6G72_RS09560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G72_RS09560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G72_RS09600	COG0154	amidase activity
I6G72_RS09605	COG4172	Belongs to the ABC transporter superfamily
I6G72_RS09610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS09615	COG0601	transmembrane transport
I6G72_RS09620	COG0747	negative chemotaxis
I6G72_RS09635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G72_RS09640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS09670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G72_RS09675	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6G72_RS09700	COG0438	transferase activity, transferring glycosyl groups
I6G72_RS09705	COG0438	transferase activity, transferring glycosyl groups
I6G72_RS09710	COG0438	transferase activity, transferring glycosyl groups
I6G72_RS09715	COG0405	Gamma-glutamyltransferase
I6G72_RS09720	COG0166	Belongs to the GPI family
I6G72_RS09735	COG0277	FAD linked oxidase domain protein
I6G72_RS09740	COG0745	RESPONSE REGULATOR receiver
I6G72_RS09755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6G72_RS09755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6G72_RS09765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G72_RS09775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G72_RS09780	COG2186	Transcriptional regulator
I6G72_RS09785	COG1368	sulfuric ester hydrolase activity
I6G72_RS09790	COG0204	Acyl-transferase
I6G72_RS09800	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6G72_RS09825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G72_RS09845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G72_RS09865	COG0193	aminoacyl-tRNA hydrolase activity
I6G72_RS09875	COG0012	GTP binding
I6G72_RS09890	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6G72_RS09895	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G72_RS09925	COG4804	nuclease activity
I6G72_RS09930	COG4773	Receptor
I6G72_RS09935	COG0488	(ABC) transporter
I6G72_RS09950	COG2814	Major facilitator Superfamily
I6G72_RS09965	COG3135	benzoate transporter
I6G72_RS09970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G72_RS09975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G72_RS09980	COG0742	ribosomal rna small subunit methyltransferase
I6G72_RS10000	COG3639	organic phosphonate transmembrane transporter activity
I6G72_RS10005	COG3639	organic phosphonate transmembrane transporter activity
I6G72_RS10010	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6G72_RS10035	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G72_RS10040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G72_RS10055	COG1546	Belongs to the CinA family
I6G72_RS10060	COG0284	orotidine-5'-phosphate decarboxylase activity
I6G72_RS10065	COG1252	NADH dehydrogenase
I6G72_RS10070	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G72_RS10075	COG0246	Mannitol dehydrogenase
I6G72_RS10085	COG1137	ATPase activity
I6G72_RS10110	COG1917	Cupin 2, conserved barrel domain protein
I6G72_RS10130	COG1846	Transcriptional regulator
I6G72_RS10140	COG0459	protein refolding
I6G72_RS10145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G72_RS10175	COG1595	DNA-templated transcription, initiation
I6G72_RS10220	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS10235	COG4948	Mandelate Racemase Muconate Lactonizing
I6G72_RS10240	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS10245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G72_RS10250	COG0583	DNA-binding transcription factor activity
I6G72_RS10275	COG0583	DNA-binding transcription factor activity
I6G72_RS10280	COG0583	DNA-binding transcription factor activity
I6G72_RS10285	COG0436	Aminotransferase
I6G72_RS10295	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS10305	COG0697	spore germination
I6G72_RS10310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G72_RS10320	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS10360	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6G72_RS10360	COG1793	dna ligase
I6G72_RS10365	COG1793	dna ligase
I6G72_RS10380	COG1132	(ABC) transporter
I6G72_RS10400	COG1230	cation diffusion facilitator family transporter
I6G72_RS10420	COG0028	Belongs to the TPP enzyme family
I6G72_RS10455	COG0583	DNA-binding transcription factor activity
I6G72_RS10460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G72_RS10470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G72_RS10480	COG0596	Alpha beta hydrolase
I6G72_RS10490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G72_RS10520	COG2814	Major facilitator Superfamily
I6G72_RS10525	COG0740	serine-type endopeptidase activity
I6G72_RS10535	COG0640	Transcriptional regulator
I6G72_RS10540	COG2203	Gaf domain
I6G72_RS10540	COG2199	diguanylate cyclase activity
I6G72_RS10545	COG0840	transmembrane signaling receptor activity
I6G72_RS10560	COG4948	Mandelate Racemase Muconate Lactonizing
I6G72_RS10565	COG0583	DNA-binding transcription factor activity
I6G72_RS10570	COG0456	acetyltransferase
I6G72_RS10570	COG0454	-acetyltransferase
I6G72_RS10580	COG0023	Translation Initiation Factor
I6G72_RS10585	COG0583	DNA-binding transcription factor activity
I6G72_RS10590	COG0656	L-ascorbic acid biosynthetic process
I6G72_RS10605	COG0667	Aldo Keto reductase
I6G72_RS10615	COG0243	molybdopterin cofactor binding
I6G72_RS10620	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G72_RS10620	COG2146	nitrite reductase [NAD(P)H] activity
I6G72_RS10625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G72_RS10625	COG2146	nitrite reductase [NAD(P)H] activity
I6G72_RS10630	COG3707	response regulator
I6G72_RS10685	COG0625	glutathione transferase activity
I6G72_RS10700	COG2814	Major facilitator Superfamily
I6G72_RS10710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G72_RS10715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G72_RS10720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G72_RS10730	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G72_RS10735	COG1845	cytochrome c oxidase, subunit III
I6G72_RS10740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G72_RS10745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G72_RS10750	COG0477	Major facilitator Superfamily
I6G72_RS10755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS10760	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G72_RS10785	COG3712	iron ion homeostasis
I6G72_RS10815	COG0583	DNA-binding transcription factor activity
I6G72_RS10830	COG4106	trans-aconitate 2-methyltransferase activity
I6G72_RS10835	COG2207	Transcriptional regulator
I6G72_RS10840	COG2807	transmembrane transport
I6G72_RS10865	COG0330	HflC and HflK could
I6G72_RS10870	COG5001	Diguanylate cyclase
I6G72_RS10890	COG4773	Receptor
I6G72_RS10895	COG4221	oxidoreductase activity
I6G72_RS10905	COG1595	DNA-templated transcription, initiation
I6G72_RS10910	COG3712	iron ion homeostasis
I6G72_RS10925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G72_RS10940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G72_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS10950	COG1285	pathogenesis
I6G72_RS10955	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6G72_RS10995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G72_RS11000	COG1396	sequence-specific DNA binding
I6G72_RS11020	COG0583	DNA-binding transcription factor activity
I6G72_RS11030	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS11065	COG0697	spore germination
I6G72_RS11080	COG0280	phosphate acetyltransferase
I6G72_RS11080	COG0281	malic enzyme
I6G72_RS11100	COG4772	TonB-dependent receptor
I6G72_RS11110	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G72_RS11115	COG1845	cytochrome c oxidase, subunit III
I6G72_RS11120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G72_RS11130	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6G72_RS11150	COG1999	signal sequence binding
I6G72_RS11170	COG4942	peptidase
I6G72_RS11175	COG1126	abc transporter atp-binding protein
I6G72_RS11180	COG0765	amino acid transport
I6G72_RS11185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS11190	COG3191	aminopeptidase activity
I6G72_RS11195	COG1272	protein, Hemolysin III
I6G72_RS11200	COG1522	sequence-specific DNA binding
I6G72_RS11210	COG1113	amino acid transport
I6G72_RS11215	COG0583	DNA-binding transcription factor activity
I6G72_RS11240	COG2378	regulation of single-species biofilm formation
I6G72_RS11255	COG1595	DNA-templated transcription, initiation
I6G72_RS11260	COG3712	iron ion homeostasis
I6G72_RS11270	COG3720	iron ion transport
I6G72_RS11275	COG4558	Periplasmic binding protein
I6G72_RS11280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G72_RS11285	COG1120	ATPase activity
I6G72_RS11290	COG1666	GTP binding
I6G72_RS11305	COG0671	phosphoesterase, PA-phosphatase related
I6G72_RS11310	COG4585	Histidine kinase
I6G72_RS11330	COG4774	siderophore transport
I6G72_RS11355	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G72_RS11395	COG0456	acetyltransferase
I6G72_RS11400	COG0583	DNA-binding transcription factor activity
I6G72_RS11405	COG2828	Protein conserved in bacteria
I6G72_RS11425	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS11440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G72_RS11475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G72_RS11480	COG0583	DNA-binding transcription factor activity
I6G72_RS11505	COG2223	nitrite transmembrane transporter activity
I6G72_RS11515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G72_RS11520	COG3383	formate dehydrogenase (NAD+) activity
I6G72_RS11540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G72_RS11550	COG0303	'Molybdopterin
I6G72_RS11555	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G72_RS11560	COG0314	molybdopterin synthase activity
I6G72_RS11570	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G72_RS11580	COG0412	Dienelactone hydrolase
I6G72_RS11590	COG0678	peroxiredoxin activity
I6G72_RS11600	COG0697	spore germination
I6G72_RS11645	COG0667	Aldo Keto reductase
I6G72_RS11650	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G72_RS11655	COG4535	Mg2 and Co2 transporter CorC
I6G72_RS11660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G72_RS11665	COG1702	phosphate starvation-inducible protein PhoH
I6G72_RS11670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G72_RS11680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G72_RS11700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G72_RS11705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G72_RS11710	COG1862	Preprotein translocase
I6G72_RS11715	COG3077	Addiction module antitoxin, RelB DinJ family
I6G72_RS11725	COG0343	queuine tRNA-ribosyltransferase activity
I6G72_RS11730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6G72_RS11740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G72_RS11755	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G72_RS11760	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G72_RS11765	COG1648	precorrin-2 dehydrogenase activity
I6G72_RS11765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G72_RS11770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G72_RS11775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS11780	COG1116	anion transmembrane transporter activity
I6G72_RS11790	COG4575	ribosome binding
I6G72_RS11805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6G72_RS11810	COG0741	lytic transglycosylase activity
I6G72_RS11825	COG0436	Aminotransferase
I6G72_RS11835	COG0281	malic enzyme
I6G72_RS11835	COG0280	phosphate acetyltransferase
I6G72_RS11845	COG2732	(Barnase) inhibitor
I6G72_RS11850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G72_RS11860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G72_RS11865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G72_RS11870	COG0126	phosphoglycerate kinase activity
I6G72_RS11885	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6G72_RS11890	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G72_RS11910	COG0625	glutathione transferase activity
I6G72_RS11945	COG0306	phosphate transporter
I6G72_RS11955	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G72_RS11965	COG0739	heme binding
I6G72_RS11975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G72_RS11985	COG0640	Transcriptional regulator
I6G72_RS11995	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6G72_RS12000	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6G72_RS12005	COG3639	organic phosphonate transmembrane transporter activity
I6G72_RS12020	COG0405	Gamma-glutamyltransferase
I6G72_RS12025	COG0583	DNA-binding transcription factor activity
I6G72_RS12030	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6G72_RS12035	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6G72_RS12040	COG3454	Phosphonate metabolism
I6G72_RS12045	COG2188	Transcriptional regulator
I6G72_RS12050	COG3624	Phosphonate C-P lyase system protein PhnG
I6G72_RS12055	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6G72_RS12060	COG3626	phosphonate metabolism
I6G72_RS12065	COG3627	carbon phosphorus lyase activity
I6G72_RS12070	COG4107	phosphonate C-P lyase system protein PhnK
I6G72_RS12075	COG4778	phosphonate C-P lyase system protein PhnL
I6G72_RS12080	COG3454	Phosphonate metabolism
I6G72_RS12090	COG1301	dicarboxylic acid transport
I6G72_RS12110	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G72_RS12120	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G72_RS12125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G72_RS12130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G72_RS12135	COG0009	L-threonylcarbamoyladenylate synthase
I6G72_RS12140	COG1414	Transcriptional regulator
I6G72_RS12145	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G72_RS12160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS12165	COG0028	Belongs to the TPP enzyme family
I6G72_RS12210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G72_RS12255	COG0028	Belongs to the TPP enzyme family
I6G72_RS12260	COG0583	DNA-binding transcription factor activity
I6G72_RS12265	COG4974	Belongs to the 'phage' integrase family
I6G72_RS12270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G72_RS12275	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6G72_RS12290	COG1686	Belongs to the peptidase S11 family
I6G72_RS12305	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS12310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G72_RS12325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G72_RS12345	COG2070	2-Nitropropane dioxygenase
I6G72_RS12365	COG1074	ATP-dependent DNA helicase activity
I6G72_RS12375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G72_RS12390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G72_RS12395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G72_RS12405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS12420	COG0745	RESPONSE REGULATOR receiver
I6G72_RS12440	COG0505	Belongs to the CarA family
I6G72_RS12445	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G72_RS12455	COG4221	oxidoreductase activity
I6G72_RS12470	COG3842	ATPase activity
I6G72_RS12490	COG2233	PERMEase
I6G72_RS12495	COG0840	transmembrane signaling receptor activity
I6G72_RS12500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G72_RS12505	COG1534	Rna-binding protein
I6G72_RS12510	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6G72_RS12515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G72_RS12525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G72_RS12535	COG0248	Ppx GppA phosphatase
I6G72_RS12560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G72_RS12565	COG2814	Major facilitator Superfamily
I6G72_RS12580	COG0583	DNA-binding transcription factor activity
I6G72_RS12585	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS12595	COG0183	Belongs to the thiolase family
I6G72_RS12615	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G72_RS12620	COG1846	Transcriptional regulator
I6G72_RS12630	COG0604	alcohol dehydrogenase
I6G72_RS12630	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS12630	COG3321	synthase
I6G72_RS12635	COG2814	Major facilitator Superfamily
I6G72_RS12640	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G72_RS12640	COG1902	pentaerythritol trinitrate reductase activity
I6G72_RS12650	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS12655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G72_RS12660	COG1024	Enoyl-CoA hydratase
I6G72_RS12665	COG0697	spore germination
I6G72_RS12670	COG1024	Enoyl-CoA hydratase
I6G72_RS12675	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS12715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G72_RS12725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G72_RS12735	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS12745	COG1024	Enoyl-CoA hydratase
I6G72_RS12750	COG1024	Enoyl-CoA hydratase
I6G72_RS12765	COG1902	pentaerythritol trinitrate reductase activity
I6G72_RS12775	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS12795	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G72_RS12815	COG0583	DNA-binding transcription factor activity
I6G72_RS12830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G72_RS12845	COG1024	Enoyl-CoA hydratase
I6G72_RS12850	COG1104	cysteine desulfurase activity
I6G72_RS12855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS12875	COG0438	transferase activity, transferring glycosyl groups
I6G72_RS12880	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G72_RS12895	COG2841	Protein conserved in bacteria
I6G72_RS12905	COG1335	isochorismatase
I6G72_RS12910	COG0583	DNA-binding transcription factor activity
I6G72_RS12915	COG2207	Transcriptional regulator
I6G72_RS12920	COG0667	Aldo Keto reductase
I6G72_RS12935	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I6G72_RS12950	COG0500	methyltransferase
I6G72_RS12980	COG0517	IMP dehydrogenase activity
I6G72_RS12995	COG3938	Belongs to the proline racemase family
I6G72_RS13000	COG1177	transmembrane transport
I6G72_RS13005	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G72_RS13010	COG3842	ATPase activity
I6G72_RS13060	COG3264	Mechanosensitive ion channel
I6G72_RS13060	COG1511	domain protein
I6G72_RS13065	COG0583	DNA-binding transcription factor activity
I6G72_RS13070	COG0427	acetyl-CoA hydrolase
I6G72_RS13075	COG0583	DNA-binding transcription factor activity
I6G72_RS13125	COG0583	DNA-binding transcription factor activity
I6G72_RS13140	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G72_RS13150	COG0477	Major facilitator Superfamily
I6G72_RS13160	COG0154	amidase activity
I6G72_RS13180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G72_RS13195	COG0495	leucyl-tRNA aminoacylation
I6G72_RS13200	COG2814	Major facilitator Superfamily
I6G72_RS13205	COG1846	Transcriptional regulator
I6G72_RS13220	COG1686	Belongs to the peptidase S11 family
I6G72_RS13255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G72_RS13260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G72_RS13265	COG2814	Major facilitator Superfamily
I6G72_RS13270	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G72_RS13280	COG4176	ABC-type proline glycine betaine transport system permease component
I6G72_RS13300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G72_RS13305	COG2706	6-phosphogluconolactonase activity
I6G72_RS13310	COG4214	carbohydrate transport
I6G72_RS13315	COG1129	ABC transporter
I6G72_RS13320	COG4213	ABC transporter substrate-binding protein
I6G72_RS13345	COG0583	DNA-binding transcription factor activity
I6G72_RS13350	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS13355	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS13360	COG0183	Belongs to the thiolase family
I6G72_RS13370	COG1802	Transcriptional regulator
I6G72_RS13380	COG1024	Enoyl-CoA hydratase
I6G72_RS13385	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS13395	COG0667	Aldo Keto reductase
I6G72_RS13405	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6G72_RS13415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G72_RS13425	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6G72_RS13450	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I6G72_RS13455	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G72_RS13460	COG4149	molybdate abc transporter
I6G72_RS13465	COG3842	ATPase activity
I6G72_RS13490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G72_RS13495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G72_RS13505	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G72_RS13510	COG0736	holo-[acyl-carrier-protein] synthase activity
I6G72_RS13525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G72_RS13535	COG0473	3-isopropylmalate dehydrogenase activity
I6G72_RS13540	COG0583	DNA-binding transcription factor activity
I6G72_RS13545	COG1858	cytochrome C peroxidase
I6G72_RS13550	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G72_RS13550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6G72_RS13555	COG2224	Isocitrate lyase
I6G72_RS13580	COG0156	8-amino-7-oxononanoate synthase activity
I6G72_RS13585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G72_RS13600	COG3278	Belongs to the heme-copper respiratory oxidase family
I6G72_RS13620	COG0348	domain, Protein
I6G72_RS13665	COG1012	belongs to the aldehyde dehydrogenase family
I6G72_RS13675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS13685	COG0765	amino acid transport
I6G72_RS13690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G72_RS13750	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G72_RS13755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS13760	COG0586	Pfam SNARE associated Golgi protein
I6G72_RS13765	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G72_RS13780	COG4608	Belongs to the ABC transporter superfamily
I6G72_RS13785	COG0444	Belongs to the ABC transporter superfamily
I6G72_RS13790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS13795	COG0601	transmembrane transport
I6G72_RS13800	COG0583	DNA-binding transcription factor activity
I6G72_RS13805	COG1764	response to oxidative stress
I6G72_RS13810	COG2205	protein histidine kinase activity
I6G72_RS13840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G72_RS13855	COG1802	Transcriptional regulator
I6G72_RS13870	COG1595	DNA-templated transcription, initiation
I6G72_RS13890	COG2084	Dehydrogenase
I6G72_RS13910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G72_RS13920	COG0582	viral genome integration into host DNA
I6G72_RS13965	COG3728	DNA packaging
I6G72_RS13990	COG1280	lysine exporter protein (LysE YggA)
I6G72_RS13995	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS14000	COG0840	transmembrane signaling receptor activity
I6G72_RS14015	COG3387	PFAM Glycoside hydrolase 15-related
I6G72_RS14020	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS14060	COG3188	usher protein
I6G72_RS14065	COG3121	Chaperone
I6G72_RS14095	COG2197	response regulator
I6G72_RS14105	COG3300	MHYT domain
I6G72_RS14105	COG5001	Diguanylate cyclase
I6G72_RS14120	COG3121	Chaperone
I6G72_RS14125	COG3188	usher protein
I6G72_RS14145	COG0642	Histidine kinase
I6G72_RS14150	COG1475	DNA binding
I6G72_RS14160	COG3969	phosphoadenosine phosphosulfate
I6G72_RS14165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G72_RS14225	COG2321	neutral zinc metallopeptidase
I6G72_RS14230	COG0009	L-threonylcarbamoyladenylate synthase
I6G72_RS14235	COG1994	Peptidase M50
I6G72_RS14240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G72_RS14245	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6G72_RS14255	COG2850	peptidyl-arginine hydroxylation
I6G72_RS14260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G72_RS14320	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS14325	COG0583	DNA-binding transcription factor activity
I6G72_RS14335	COG3360	Dodecin
I6G72_RS14370	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6G72_RS14375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS14380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G72_RS14420	COG0668	transmembrane transport
I6G72_RS14440	COG0483	inositol monophosphate 1-phosphatase activity
I6G72_RS14445	COG4804	nuclease activity
I6G72_RS14450	COG1477	protein flavinylation
I6G72_RS14460	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6G72_RS14475	COG4263	nitrous-oxide reductase activity
I6G72_RS14490	COG1253	flavin adenine dinucleotide binding
I6G72_RS14495	COG1968	undecaprenyl-diphosphatase activity
I6G72_RS14500	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G72_RS14515	COG0215	cysteine-tRNA ligase activity
I6G72_RS14525	COG0825	malonyl-CoA metabolic process
I6G72_RS14530	COG0037	tRNA processing
I6G72_RS14535	COG0527	aspartate kinase activity
I6G72_RS14565	COG0348	domain, Protein
I6G72_RS14585	COG3278	Belongs to the heme-copper respiratory oxidase family
I6G72_RS14600	COG3258	Cytochrome c
I6G72_RS14605	COG2863	cytochrome
I6G72_RS14620	COG0784	Response regulator, receiver
I6G72_RS14620	COG2205	protein histidine kinase activity
I6G72_RS14630	COG2205	protein histidine kinase activity
I6G72_RS14630	COG0784	Response regulator, receiver
I6G72_RS14640	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6G72_RS14645	COG1051	belongs to the nudix hydrolase family
I6G72_RS14655	COG1309	transcriptional regulator
I6G72_RS14660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G72_RS14690	COG0583	DNA-binding transcription factor activity
I6G72_RS14710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G72_RS14720	COG1414	Transcriptional regulator
I6G72_RS14735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G72_RS14740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G72_RS14750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G72_RS14755	COG3395	kinase activity
I6G72_RS14765	COG1132	(ABC) transporter
I6G72_RS14775	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS14785	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS14800	COG0183	Belongs to the thiolase family
I6G72_RS14805	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G72_RS14805	COG1024	Enoyl-CoA hydratase
I6G72_RS14815	COG1024	Enoyl-CoA hydratase
I6G72_RS14815	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G72_RS14825	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS14830	COG1309	transcriptional regulator
I6G72_RS14840	COG2197	response regulator
I6G72_RS14845	COG2197	response regulator
I6G72_RS14850	COG0297	glycogen (starch) synthase activity
I6G72_RS14855	COG0110	maltose O-acetyltransferase activity
I6G72_RS14860	COG0463	Glycosyl transferase, family 2
I6G72_RS14885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G72_RS14905	COG1051	belongs to the nudix hydrolase family
I6G72_RS14915	COG1596	polysaccharide export
I6G72_RS14920	COG3206	protein involved in exopolysaccharide biosynthesis
I6G72_RS14920	COG0489	protein tyrosine kinase activity
I6G72_RS14925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G72_RS14930	COG0166	Belongs to the GPI family
I6G72_RS14935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G72_RS14940	COG1045	serine acetyltransferase
I6G72_RS14945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G72_RS14960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G72_RS14980	COG0598	Magnesium transport protein CorA
I6G72_RS14995	COG0601	transmembrane transport
I6G72_RS15000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS15005	COG4172	Belongs to the ABC transporter superfamily
I6G72_RS15010	COG1846	Transcriptional regulator
I6G72_RS15055	COG4964	Belongs to the GSP D family
I6G72_RS15110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G72_RS15125	COG3384	dioxygenase
I6G72_RS15140	COG2814	Major facilitator Superfamily
I6G72_RS15165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G72_RS15175	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS15205	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS15210	COG0604	alcohol dehydrogenase
I6G72_RS15210	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS15210	COG3321	synthase
I6G72_RS15225	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G72_RS15235	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS15240	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G72_RS15245	COG3246	L-lysine catabolic process to acetate
I6G72_RS15250	COG0371	Dehydrogenase
I6G72_RS15255	COG1802	Transcriptional regulator
I6G72_RS15260	COG3959	Transketolase, thiamine diphosphate binding domain
I6G72_RS15265	COG3958	Transketolase
I6G72_RS15270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G72_RS15280	COG4948	Mandelate Racemase Muconate Lactonizing
I6G72_RS15285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS15295	COG0765	amino acid transport
I6G72_RS15305	COG2721	sulfolactate sulfo-lyase activity
I6G72_RS15315	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS15320	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G72_RS15325	COG1414	Transcriptional regulator
I6G72_RS15340	COG0596	Alpha beta hydrolase
I6G72_RS15360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G72_RS15370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G72_RS15375	COG1120	ATPase activity
I6G72_RS15390	COG4771	TonB-dependent receptor
I6G72_RS15405	COG0477	Major facilitator Superfamily
I6G72_RS15415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G72_RS15425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G72_RS15450	COG3852	Histidine kinase
I6G72_RS15460	COG1546	Belongs to the CinA family
I6G72_RS15460	COG1058	Belongs to the CinA family
I6G72_RS15475	COG1113	amino acid transport
I6G72_RS15485	COG1640	4-alpha-glucanotransferase
I6G72_RS15490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G72_RS15500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G72_RS15505	COG0366	Alpha amylase catalytic
I6G72_RS15510	COG0366	Alpha amylase catalytic
I6G72_RS15515	COG0297	glycogen (starch) synthase activity
I6G72_RS15520	COG0392	lysyltransferase activity
I6G72_RS15525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G72_RS15530	COG3568	Endonuclease Exonuclease Phosphatase
I6G72_RS15535	COG0387	Pfam Sodium calcium exchanger
I6G72_RS15565	COG0166	Belongs to the GPI family
I6G72_RS15575	COG0668	transmembrane transport
I6G72_RS15595	COG5265	(ABC) transporter
I6G72_RS15605	COG0438	transferase activity, transferring glycosyl groups
I6G72_RS15610	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS15615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G72_RS15625	COG2192	nodulation
I6G72_RS15715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS15720	COG2207	Transcriptional regulator
I6G72_RS15735	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G72_RS15740	COG3608	succinylglutamate desuccinylase aspartoacylase
I6G72_RS15740	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6G72_RS15760	COG0505	Belongs to the CarA family
I6G72_RS15775	COG1850	ribulose-bisphosphate carboxylase activity
I6G72_RS15785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6G72_RS15790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G72_RS15795	COG1609	Transcriptional regulator
I6G72_RS15810	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6G72_RS15815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6G72_RS15820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6G72_RS15850	COG3384	dioxygenase
I6G72_RS15905	COG0583	DNA-binding transcription factor activity
I6G72_RS15920	COG1024	Enoyl-CoA hydratase
I6G72_RS15960	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS15975	COG1396	sequence-specific DNA binding
I6G72_RS16035	COG0811	peptide transport
I6G72_RS16065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G72_RS16085	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
I6G72_RS16090	COG1116	anion transmembrane transporter activity
I6G72_RS16095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS16100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G72_RS16100	COG1116	anion transmembrane transporter activity
I6G72_RS16105	COG2197	response regulator
I6G72_RS16115	COG1131	(ABC) transporter
I6G72_RS16120	COG0842	Transport permease protein
I6G72_RS16135	COG0183	Belongs to the thiolase family
I6G72_RS16160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G72_RS16165	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS16180	COG0604	alcohol dehydrogenase
I6G72_RS16180	COG3321	synthase
I6G72_RS16195	COG4638	Rieske (2fe-2S)
I6G72_RS16225	COG1278	Cold shock
I6G72_RS16235	COG1272	protein, Hemolysin III
I6G72_RS16265	COG2169	Transcriptional regulator
I6G72_RS16270	COG2814	Major facilitator Superfamily
I6G72_RS16275	COG0583	DNA-binding transcription factor activity
I6G72_RS16285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G72_RS16335	COG2837	iron assimilation
I6G72_RS16375	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G72_RS16380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G72_RS16390	COG2814	Major facilitator Superfamily
I6G72_RS16405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G72_RS16410	COG2011	ABC-type metal ion transport system permease component
I6G72_RS16445	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS16450	COG3618	amidohydrolase
I6G72_RS16465	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6G72_RS16480	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS16485	COG1473	amidohydrolase
I6G72_RS16500	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS16505	COG2272	Belongs to the type-B carboxylesterase lipase family
I6G72_RS16515	COG0583	DNA-binding transcription factor activity
I6G72_RS16525	COG2951	lytic endotransglycosylase activity
I6G72_RS16530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6G72_RS16535	COG0519	Catalyzes the synthesis of GMP from XMP
I6G72_RS16555	COG1595	DNA-templated transcription, initiation
I6G72_RS16570	COG0519	Catalyzes the synthesis of GMP from XMP
I6G72_RS16580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS16595	COG4172	Belongs to the ABC transporter superfamily
I6G72_RS16605	COG1522	sequence-specific DNA binding
I6G72_RS16665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G72_RS16675	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS16700	COG0625	glutathione transferase activity
I6G72_RS16715	COG3530	Putative quorum-sensing-regulated virulence factor
I6G72_RS16725	COG2814	Major facilitator Superfamily
I6G72_RS16760	COG0443	Heat shock 70 kDa protein
I6G72_RS16765	COG0583	DNA-binding transcription factor activity
I6G72_RS16770	COG0494	nUDIX hydrolase
I6G72_RS16790	COG0477	Major facilitator Superfamily
I6G72_RS16800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G72_RS16810	COG0542	response to heat
I6G72_RS16835	COG5441	Belongs to the UPF0261 family
I6G72_RS16840	COG5564	TIM-barrel signal transduction protein
I6G72_RS16855	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6G72_RS16870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G72_RS16880	COG1562	ergosterol biosynthetic process
I6G72_RS16885	COG1562	ergosterol biosynthetic process
I6G72_RS16890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G72_RS16895	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS16905	COG3971	2-oxopent-4-enoate hydratase activity
I6G72_RS16920	COG1012	belongs to the aldehyde dehydrogenase family
I6G72_RS16925	COG3384	dioxygenase
I6G72_RS16955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G72_RS16965	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS16975	COG2186	Transcriptional regulator
I6G72_RS16980	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G72_RS16985	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS17000	COG0583	DNA-binding transcription factor activity
I6G72_RS17005	COG0268	Binds directly to 16S ribosomal RNA
I6G72_RS17015	COG0728	peptidoglycan biosynthetic process
I6G72_RS17025	COG0563	adenylate kinase activity
I6G72_RS17030	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6G72_RS17035	COG2835	tetraacyldisaccharide 4'-kinase activity
I6G72_RS17045	COG1663	tetraacyldisaccharide 4'-kinase activity
I6G72_RS17055	COG0811	peptide transport
I6G72_RS17060	COG1570	exodeoxyribonuclease VII activity
I6G72_RS17070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G72_RS17080	COG0038	chloride channel
I6G72_RS17085	COG0183	Belongs to the thiolase family
I6G72_RS17095	COG1278	Cold shock
I6G72_RS17100	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6G72_RS17105	COG2373	Large extracellular alpha-helical protein
I6G72_RS17110	COG4953	penicillin-binding protein 1C
I6G72_RS17120	COG2995	paraquat-inducible protein a
I6G72_RS17125	COG3008	intermembrane lipid transfer
I6G72_RS17135	COG0506	proline dehydrogenase activity
I6G72_RS17135	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G72_RS17135	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G72_RS17165	COG2271	Major facilitator Superfamily
I6G72_RS17185	COG0625	glutathione transferase activity
I6G72_RS17190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G72_RS17200	COG1764	response to oxidative stress
I6G72_RS17215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS17220	COG0765	amino acid transport
I6G72_RS17225	COG0765	amino acid transport
I6G72_RS17230	COG1126	abc transporter atp-binding protein
I6G72_RS17235	COG1902	pentaerythritol trinitrate reductase activity
I6G72_RS17285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G72_RS17290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G72_RS17295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G72_RS17300	COG0196	riboflavin kinase activity
I6G72_RS17305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G72_RS17310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G72_RS17310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G72_RS17325	COG0210	DNA helicase
I6G72_RS17335	COG1858	cytochrome C peroxidase
I6G72_RS17345	COG4771	TonB-dependent receptor
I6G72_RS17355	COG4771	TonB-dependent receptor
I6G72_RS17360	COG4771	TonB-dependent receptor
I6G72_RS17375	COG0488	(ABC) transporter
I6G72_RS17380	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G72_RS17390	COG2171	N-acyltransferase activity
I6G72_RS17470	COG1475	DNA binding
I6G72_RS17485	COG3546	catalase activity
I6G72_RS17490	COG3685	Protein conserved in bacteria
I6G72_RS17515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G72_RS17615	COG0740	serine-type endopeptidase activity
I6G72_RS17810	COG2814	Major facilitator Superfamily
I6G72_RS17825	COG0277	FAD linked oxidase domain protein
I6G72_RS17850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6G72_RS17885	COG0583	DNA-binding transcription factor activity
I6G72_RS17895	COG0251	oxidation-reduction process
I6G72_RS17920	COG1278	Cold shock
I6G72_RS17930	COG1278	Cold shock
I6G72_RS17940	COG0501	Belongs to the peptidase M48B family
I6G72_RS17945	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G72_RS17950	COG0740	serine-type endopeptidase activity
I6G72_RS17955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6G72_RS17960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G72_RS17965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G72_RS17975	COG0556	nucleotide-excision repair
I6G72_RS17980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G72_RS17990	COG1104	cysteine desulfurase activity
I6G72_RS17995	COG0822	iron-sulfur transferase activity
I6G72_RS18000	COG0316	Belongs to the HesB IscA family
I6G72_RS18005	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G72_RS18010	COG0443	Heat shock 70 kDa protein
I6G72_RS18015	COG0633	Ferredoxin
I6G72_RS18020	COG2975	iron-sulfur cluster assembly
I6G72_RS18025	COG1803	Methylglyoxal synthase
I6G72_RS18035	COG1024	Enoyl-CoA hydratase
I6G72_RS18065	COG1022	Amp-dependent synthetase and ligase
I6G72_RS18070	COG0183	Belongs to the thiolase family
I6G72_RS18075	COG1309	transcriptional regulator
I6G72_RS18080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G72_RS18085	COG3135	benzoate transporter
I6G72_RS18100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G72_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS18115	COG2271	Major facilitator Superfamily
I6G72_RS18135	COG1136	(ABC) transporter
I6G72_RS18140	COG0084	hydrolase, TatD family'
I6G72_RS18150	COG0745	RESPONSE REGULATOR receiver
I6G72_RS18155	COG4771	TonB-dependent receptor
I6G72_RS18160	COG4607	ABC-type enterochelin transport system periplasmic component
I6G72_RS18165	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G72_RS18170	COG4605	iron ion homeostasis
I6G72_RS18175	COG4604	ABC transporter, ATP-binding protein
I6G72_RS18190	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6G72_RS18215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G72_RS18220	COG4133	protoheme IX ABC transporter activity
I6G72_RS18225	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS18230	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS18235	COG0633	Ferredoxin
I6G72_RS18265	COG1280	lysine exporter protein (LysE YggA)
I6G72_RS18275	COG3119	arylsulfatase activity
I6G72_RS18290	COG2304	oxidoreductase activity
I6G72_RS18310	COG0714	Associated with various cellular activities
I6G72_RS18315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6G72_RS18350	COG0459	protein refolding
I6G72_RS18355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G72_RS18365	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G72_RS18390	COG3093	addiction module antidote protein HigA
I6G72_RS18400	COG2149	membrane
I6G72_RS18435	COG3119	arylsulfatase activity
I6G72_RS18445	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS18450	COG0277	FAD linked oxidase domain protein
I6G72_RS18470	COG0159	tryptophan synthase activity
I6G72_RS18480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G72_RS18485	COG0477	Major facilitator Superfamily
I6G72_RS18490	COG0583	DNA-binding transcription factor activity
I6G72_RS18500	COG0583	DNA-binding transcription factor activity
I6G72_RS18510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G72_RS18525	COG0613	PHP domain protein
I6G72_RS18535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G72_RS18540	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6G72_RS18540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6G72_RS18550	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G72_RS18550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G72_RS18555	COG4774	siderophore transport
I6G72_RS18560	COG3712	iron ion homeostasis
I6G72_RS18565	COG1595	DNA-templated transcription, initiation
I6G72_RS18590	COG0642	Histidine kinase
I6G72_RS18605	COG0583	DNA-binding transcription factor activity
I6G72_RS18615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G72_RS18625	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS18635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G72_RS18640	COG0583	DNA-binding transcription factor activity
I6G72_RS18645	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS18670	COG2205	protein histidine kinase activity
I6G72_RS18670	COG0745	RESPONSE REGULATOR receiver
I6G72_RS18670	COG3292	Two component regulator propeller
I6G72_RS18675	COG2205	protein histidine kinase activity
I6G72_RS18675	COG2198	Histidine kinase
I6G72_RS18675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS18675	COG0784	Response regulator, receiver
I6G72_RS18680	COG0583	DNA-binding transcription factor activity
I6G72_RS18715	COG1953	Uracil, thiamine, allantoin
I6G72_RS18765	COG0583	DNA-binding transcription factor activity
I6G72_RS18780	COG4774	siderophore transport
I6G72_RS18785	COG4774	siderophore transport
I6G72_RS18790	COG5001	Diguanylate cyclase
I6G72_RS18845	COG0583	DNA-binding transcription factor activity
I6G72_RS18870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G72_RS18920	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS18925	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G72_RS18930	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS18935	COG0583	DNA-binding transcription factor activity
I6G72_RS18950	COG0747	negative chemotaxis
I6G72_RS18955	COG4608	Belongs to the ABC transporter superfamily
I6G72_RS18965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS18970	COG0601	transmembrane transport
I6G72_RS18975	COG2072	flavoprotein involved in K transport
I6G72_RS19035	COG0419	ATPase involved in DNA repair
I6G72_RS19040	COG1674	ftsk spoiiie
I6G72_RS19345	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS19350	COG0583	DNA-binding transcription factor activity
I6G72_RS19380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G72_RS19390	COG0583	DNA-binding transcription factor activity
I6G72_RS19420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G72_RS19420	COG0519	Catalyzes the synthesis of GMP from XMP
I6G72_RS19445	COG4691	Plasmid stability protein
I6G72_RS19475	COG0798	PFAM Bile acid sodium symporter
I6G72_RS19510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G72_RS19520	COG0582	viral genome integration into host DNA
I6G72_RS19595	COG3077	Addiction module antitoxin, RelB DinJ family
I6G72_RS19605	COG1475	DNA binding
I6G72_RS19615	COG5489	Protein of unknown function (DUF736)
I6G72_RS19645	COG1192	Involved in chromosome partitioning
I6G72_RS19670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G72_RS19680	COG2814	Major facilitator Superfamily
I6G72_RS19705	COG0640	Transcriptional regulator
I6G72_RS19710	COG1230	cation diffusion facilitator family transporter
I6G72_RS19715	COG1937	Protein conserved in bacteria
I6G72_RS19720	COG2814	Major facilitator Superfamily
I6G72_RS19725	COG0640	Transcriptional regulator
I6G72_RS19735	COG0789	Transcriptional regulator
I6G72_RS19740	COG0633	Ferredoxin
I6G72_RS19775	COG3621	Patatin-like phospholipase
I6G72_RS19795	COG3328	transposase activity
I6G72_RS19810	COG4264	IucA IucC family
I6G72_RS19845	COG0431	NADPH-dependent FMN reductase
I6G72_RS19850	COG0583	DNA-binding transcription factor activity
I6G72_RS19855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G72_RS19865	COG0640	Transcriptional regulator
I6G72_RS19870	COG0640	Transcriptional regulator
I6G72_RS19900	COG2207	Transcriptional regulator
I6G72_RS19905	COG4221	oxidoreductase activity
I6G72_RS19915	COG2267	carboxylic ester hydrolase activity
I6G72_RS19920	COG2207	Transcriptional regulator
I6G72_RS19940	COG2205	protein histidine kinase activity
I6G72_RS19955	COG0583	DNA-binding transcription factor activity
I6G72_RS19970	COG0165	Argininosuccinate lyase
I6G72_RS19990	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6G72_RS20040	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS20055	COG0456	acetyltransferase
I6G72_RS20085	COG0583	DNA-binding transcription factor activity
I6G72_RS20100	COG0154	amidase activity
I6G72_RS20105	COG0840	transmembrane signaling receptor activity
I6G72_RS20130	COG2201	protein-glutamate methylesterase activity
I6G72_RS20135	COG3706	GGDEF domain
I6G72_RS20135	COG2203	Gaf domain
I6G72_RS20135	COG4251	negative regulation of phosphorylation
I6G72_RS20135	COG5001	Diguanylate cyclase
I6G72_RS20140	COG4149	molybdate abc transporter
I6G72_RS20145	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G72_RS20150	COG3842	ATPase activity
I6G72_RS20155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G72_RS20160	COG1522	sequence-specific DNA binding
I6G72_RS20170	COG2010	Cytochrome c
I6G72_RS20170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G72_RS20175	COG1335	isochorismatase
I6G72_RS20180	COG2309	aminopeptidase activity
I6G72_RS20185	COG0596	Alpha beta hydrolase
I6G72_RS20195	COG2080	2 iron, 2 sulfur cluster binding
I6G72_RS20200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G72_RS20200	COG2010	Cytochrome c
I6G72_RS20205	COG0477	Major facilitator Superfamily
I6G72_RS20210	COG1846	Transcriptional regulator
I6G72_RS20220	COG0583	DNA-binding transcription factor activity
I6G72_RS20235	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6G72_RS20245	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS20250	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS20255	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS20260	COG0183	Belongs to the thiolase family
I6G72_RS20265	COG1024	Enoyl-CoA hydratase
I6G72_RS20265	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G72_RS20270	COG0583	DNA-binding transcription factor activity
I6G72_RS20295	COG0148	phosphopyruvate hydratase activity
I6G72_RS20305	COG2733	membrane
I6G72_RS20310	COG2032	superoxide dismutase activity
I6G72_RS20315	COG0625	glutathione transferase activity
I6G72_RS20495	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I6G72_RS20505	COG1360	Flagellar Motor Protein
I6G72_RS20560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G72_RS20580	COG3541	Predicted nucleotidyltransferase
I6G72_RS20585	COG1846	Transcriptional regulator
I6G72_RS20615	COG0583	DNA-binding transcription factor activity
I6G72_RS20625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G72_RS20635	COG0697	spore germination
I6G72_RS20645	COG4941	Belongs to the sigma-70 factor family
I6G72_RS20655	COG3795	YCII-related domain
I6G72_RS20660	COG3795	YCII-related domain
I6G72_RS20675	COG3047	cAMP biosynthetic process
I6G72_RS20675	COG2885	chlorophyll binding
I6G72_RS20695	COG2207	Transcriptional regulator
I6G72_RS20705	COG1683	Conserved Protein
I6G72_RS20725	COG1309	transcriptional regulator
I6G72_RS20730	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS20740	COG0667	Aldo Keto reductase
I6G72_RS20745	COG0477	Major facilitator Superfamily
I6G72_RS20755	COG1414	Transcriptional regulator
I6G72_RS20765	COG2345	Transcriptional regulator
I6G72_RS20770	COG4774	siderophore transport
I6G72_RS20790	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6G72_RS20870	COG0840	transmembrane signaling receptor activity
I6G72_RS20895	COG3038	cytochrome b561
I6G72_RS20935	COG0583	DNA-binding transcription factor activity
I6G72_RS20940	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS20950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G72_RS20960	COG0667	Aldo Keto reductase
I6G72_RS20980	COG0587	DNA-directed DNA polymerase activity
I6G72_RS21000	COG0833	amino acid
I6G72_RS21005	COG0400	carboxylic ester hydrolase activity
I6G72_RS21015	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS21025	COG0028	Belongs to the TPP enzyme family
I6G72_RS21040	COG1566	PFAM secretion protein HlyD family protein
I6G72_RS21050	COG1289	transmembrane transporter activity
I6G72_RS21060	COG0720	synthase
I6G72_RS21065	COG0602	queuosine metabolic process
I6G72_RS21070	COG0513	Belongs to the DEAD box helicase family
I6G72_RS21075	COG1414	Transcriptional regulator
I6G72_RS21090	COG0747	negative chemotaxis
I6G72_RS21095	COG0601	transmembrane transport
I6G72_RS21100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS21105	COG4172	Belongs to the ABC transporter superfamily
I6G72_RS21110	COG1228	amidohydrolase
I6G72_RS21115	COG0523	cobalamin synthesis protein
I6G72_RS21125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G72_RS21130	COG0235	Class ii aldolase
I6G72_RS21145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS21150	COG1595	DNA-templated transcription, initiation
I6G72_RS21155	COG3712	iron ion homeostasis
I6G72_RS21170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS21175	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6G72_RS21180	COG4521	taurine ABC transporter
I6G72_RS21185	COG0583	DNA-binding transcription factor activity
I6G72_RS21210	COG1966	Carbon starvation protein
I6G72_RS21215	COG2879	small protein
I6G72_RS21220	COG0697	spore germination
I6G72_RS21225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS21255	COG0783	Belongs to the Dps family
I6G72_RS21270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G72_RS21275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G72_RS21285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G72_RS21290	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6G72_RS21295	COG0745	RESPONSE REGULATOR receiver
I6G72_RS21300	COG5002	protein histidine kinase activity
I6G72_RS21315	COG2070	2-Nitropropane dioxygenase
I6G72_RS21335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS21365	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS21375	COG0583	DNA-binding transcription factor activity
I6G72_RS21420	COG2223	nitrite transmembrane transporter activity
I6G72_RS21425	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G72_RS21430	COG1140	nitrate reductase beta subunit
I6G72_RS21435	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G72_RS21440	COG2181	nitrate reductase activity
I6G72_RS21445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G72_RS21450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G72_RS21455	COG0288	reversible hydration of carbon dioxide
I6G72_RS21460	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6G72_RS21465	COG3850	Histidine kinase
I6G72_RS21470	COG2197	response regulator
I6G72_RS21475	COG0826	peptidase U32
I6G72_RS21480	COG0826	peptidase U32
I6G72_RS21485	COG3154	lipid carrier protein
I6G72_RS21490	COG4597	amino acid ABC transporter
I6G72_RS21495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS21530	COG1116	anion transmembrane transporter activity
I6G72_RS21530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G72_RS21535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G72_RS21540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS21565	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G72_RS21580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G72_RS21585	COG1802	Transcriptional regulator
I6G72_RS21595	COG4948	Mandelate Racemase Muconate Lactonizing
I6G72_RS21635	COG0251	oxidation-reduction process
I6G72_RS21660	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6G72_RS21685	COG0436	Aminotransferase
I6G72_RS21690	COG0765	amino acid transport
I6G72_RS21700	COG1126	abc transporter atp-binding protein
I6G72_RS21720	COG0583	DNA-binding transcription factor activity
I6G72_RS21750	COG4566	intracellular signal transduction
I6G72_RS21755	COG4191	Histidine kinase
I6G72_RS21765	COG1846	Transcriptional regulator
I6G72_RS21775	COG0583	DNA-binding transcription factor activity
I6G72_RS21780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G72_RS21805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G72_RS21815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G72_RS21820	COG2070	2-Nitropropane dioxygenase
I6G72_RS21825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS21830	COG0765	amino acid transport
I6G72_RS21835	COG1126	abc transporter atp-binding protein
I6G72_RS21840	COG1120	ATPase activity
I6G72_RS21845	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G72_RS21850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G72_RS21895	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6G72_RS21905	COG0390	transport system, permease component
I6G72_RS21910	COG0586	Pfam SNARE associated Golgi protein
I6G72_RS21925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G72_RS21930	COG3842	ATPase activity
I6G72_RS21935	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6G72_RS21940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G72_RS21950	COG0745	RESPONSE REGULATOR receiver
I6G72_RS21970	COG2721	sulfolactate sulfo-lyase activity
I6G72_RS21975	COG3386	PFAM SMP-30 Gluconolaconase
I6G72_RS21980	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS22000	COG1276	copper resistance
I6G72_RS22010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G72_RS22010	COG0519	Catalyzes the synthesis of GMP from XMP
I6G72_RS22015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G72_RS22025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS22030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS22035	COG2358	TRAP transporter, solute receptor (TAXI family
I6G72_RS22045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G72_RS22050	COG1335	isochorismatase
I6G72_RS22055	COG0583	DNA-binding transcription factor activity
I6G72_RS22065	COG0747	negative chemotaxis
I6G72_RS22070	COG0601	transmembrane transport
I6G72_RS22080	COG0444	Belongs to the ABC transporter superfamily
I6G72_RS22100	COG0583	DNA-binding transcription factor activity
I6G72_RS22105	COG0626	cystathionine gamma-synthase activity
I6G72_RS22110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS22115	COG4597	amino acid ABC transporter
I6G72_RS22120	COG0765	amino acid transport
I6G72_RS22125	COG1126	abc transporter atp-binding protein
I6G72_RS22145	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6G72_RS22155	COG0640	Transcriptional regulator
I6G72_RS22165	COG0798	PFAM Bile acid sodium symporter
I6G72_RS22175	COG0431	NADPH-dependent FMN reductase
I6G72_RS22190	COG0625	glutathione transferase activity
I6G72_RS22205	COG0579	oxidoreductase
I6G72_RS22215	COG0477	Major facilitator Superfamily
I6G72_RS22230	COG0625	glutathione transferase activity
I6G72_RS22260	COG3971	2-oxopent-4-enoate hydratase activity
I6G72_RS22270	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G72_RS22285	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6G72_RS22300	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G72_RS22320	COG0251	oxidation-reduction process
I6G72_RS22330	COG0747	negative chemotaxis
I6G72_RS22335	COG0601	transmembrane transport
I6G72_RS22345	COG0444	Belongs to the ABC transporter superfamily
I6G72_RS22350	COG4608	Belongs to the ABC transporter superfamily
I6G72_RS22355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6G72_RS22365	COG0531	amino acid
I6G72_RS22380	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G72_RS22390	COG0628	permease
I6G72_RS22410	COG0793	Belongs to the peptidase S41A family
I6G72_RS22435	COG4521	taurine ABC transporter
I6G72_RS22440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G72_RS22445	COG1116	anion transmembrane transporter activity
I6G72_RS22475	COG3706	GGDEF domain
I6G72_RS22485	COG0789	Transcriptional regulator
I6G72_RS22660	COG2205	protein histidine kinase activity
I6G72_RS22670	COG1253	flavin adenine dinucleotide binding
I6G72_RS22705	COG4774	siderophore transport
I6G72_RS22720	COG3300	MHYT domain
I6G72_RS22720	COG5001	Diguanylate cyclase
I6G72_RS22725	COG1289	transmembrane transporter activity
I6G72_RS22735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G72_RS22755	COG0693	protein deglycase activity
I6G72_RS22775	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS22810	COG2204	response regulator
I6G72_RS22815	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G72_RS22840	COG2814	Major facilitator Superfamily
I6G72_RS22855	COG3300	MHYT domain
I6G72_RS22855	COG5001	Diguanylate cyclase
I6G72_RS22860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G72_RS22865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G72_RS22890	COG0488	(ABC) transporter
I6G72_RS22895	COG0688	phosphatidylethanolamine metabolic process
I6G72_RS22905	COG1408	metallophosphoesterase
I6G72_RS22915	COG2814	Major facilitator Superfamily
I6G72_RS22925	COG1464	Belongs to the NlpA lipoprotein family
I6G72_RS22935	COG0010	Belongs to the arginase family
I6G72_RS22955	COG2363	Small membrane protein
I6G72_RS22960	COG0697	spore germination
I6G72_RS22970	COG2133	pyrroloquinoline quinone binding
I6G72_RS22975	COG0625	glutathione transferase activity
I6G72_RS22980	COG0583	DNA-binding transcription factor activity
I6G72_RS22990	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6G72_RS22995	COG1794	racemase activity, acting on amino acids and derivatives
I6G72_RS23020	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G72_RS23035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6G72_RS23045	COG1653	transport
I6G72_RS23050	COG1175	transmembrane transport
I6G72_RS23055	COG0395	ABC-type sugar transport system, permease component
I6G72_RS23060	COG3842	ATPase activity
I6G72_RS23075	COG2205	protein histidine kinase activity
I6G72_RS23080	COG0745	RESPONSE REGULATOR receiver
I6G72_RS23095	COG3866	Pectate lyase
I6G72_RS23100	COG1560	Kdo2-lipid A biosynthetic process
I6G72_RS23100	COG4783	chaperone-mediated protein folding
I6G72_RS23125	COG0438	transferase activity, transferring glycosyl groups
I6G72_RS23130	COG0457	Tetratricopeptide repeat
I6G72_RS23140	COG0783	Belongs to the Dps family
I6G72_RS23150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G72_RS23160	COG0583	DNA-binding transcription factor activity
I6G72_RS23175	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS23185	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G72_RS23190	COG4149	molybdate abc transporter
I6G72_RS23195	COG3842	ATPase activity
I6G72_RS23200	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS23205	COG1690	Belongs to the RtcB family
I6G72_RS23210	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6G72_RS23215	COG1741	Belongs to the pirin family
I6G72_RS23220	COG1741	Belongs to the pirin family
I6G72_RS23225	COG0583	DNA-binding transcription factor activity
I6G72_RS23230	COG2204	response regulator
I6G72_RS23240	COG0174	glutamine synthetase
I6G72_RS23245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G72_RS23250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G72_RS23265	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS23275	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6G72_RS23280	COG1561	YicC-like family, N-terminal region
I6G72_RS23285	COG0833	amino acid
I6G72_RS23290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G72_RS23305	COG0791	NLP P60 protein
I6G72_RS23310	COG3210	domain, Protein
I6G72_RS23315	COG2831	hemolysin activation secretion protein
I6G72_RS23325	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS23330	COG2863	cytochrome
I6G72_RS23335	COG3258	Cytochrome c
I6G72_RS23340	COG0194	GDP metabolic process
I6G72_RS23345	COG1758	RNA polymerase activity
I6G72_RS23350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G72_RS23360	COG1335	isochorismatase
I6G72_RS23365	COG1126	abc transporter atp-binding protein
I6G72_RS23370	COG0765	amino acid transport
I6G72_RS23375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS23415	COG2816	NAD+ diphosphatase activity
I6G72_RS23435	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G72_RS23465	COG4336	lyase activity
I6G72_RS23470	COG0583	DNA-binding transcription factor activity
I6G72_RS23485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6G72_RS23500	COG0583	DNA-binding transcription factor activity
I6G72_RS23515	COG0560	Phosphoserine phosphatase
I6G72_RS23520	COG0583	DNA-binding transcription factor activity
I6G72_RS23525	COG3842	ATPase activity
I6G72_RS23530	COG1178	ABC-type Fe3 transport system permease component
I6G72_RS23540	COG4181	ATPase activity
I6G72_RS23550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G72_RS23560	COG0584	glycerophosphoryl diester phosphodiesterase
I6G72_RS23565	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G72_RS23575	COG0678	peroxiredoxin activity
I6G72_RS23575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G72_RS23590	COG0789	Transcriptional regulator
I6G72_RS23595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G72_RS23600	COG2814	Major facilitator Superfamily
I6G72_RS23605	COG0583	DNA-binding transcription factor activity
I6G72_RS23640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6G72_RS23645	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G72_RS23650	COG2252	PERMEase
I6G72_RS23660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G72_RS23665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G72_RS23700	COG0488	(ABC) transporter
I6G72_RS23705	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G72_RS23725	COG1320	monovalent cation:proton antiporter activity
I6G72_RS23730	COG2212	antiporter activity
I6G72_RS23735	COG1863	multisubunit Na H antiporter MnhE subunit
I6G72_RS23740	COG0651	ATP synthesis coupled electron transport
I6G72_RS23745	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G72_RS23750	COG2111	Na H antiporter
I6G72_RS23750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G72_RS23780	COG0420	3'-5' exonuclease activity
I6G72_RS23785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G72_RS23820	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS23825	COG1959	2 iron, 2 sulfur cluster binding
I6G72_RS23830	COG3634	alkyl hydroperoxide reductase activity
I6G72_RS23850	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G72_RS23855	COG0346	lactoylglutathione lyase activity
I6G72_RS23900	COG0395	ABC-type sugar transport system, permease component
I6G72_RS23910	COG3842	ATPase activity
I6G72_RS23915	COG3842	ATPase activity
I6G72_RS23940	COG2130	NADP-dependent
I6G72_RS23955	COG1131	(ABC) transporter
I6G72_RS23960	COG0842	Transport permease protein
I6G72_RS23975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G72_RS24005	COG1902	pentaerythritol trinitrate reductase activity
I6G72_RS24040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G72_RS24055	COG0840	transmembrane signaling receptor activity
I6G72_RS24065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G72_RS24085	COG2814	Major facilitator Superfamily
I6G72_RS24090	COG0386	Belongs to the glutathione peroxidase family
I6G72_RS24095	COG1522	sequence-specific DNA binding
I6G72_RS24105	COG0625	glutathione transferase activity
I6G72_RS24120	COG0095	Lipoate-protein ligase
I6G72_RS24130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G72_RS24140	COG0010	Belongs to the arginase family
I6G72_RS24145	COG1126	abc transporter atp-binding protein
I6G72_RS24150	COG0765	amino acid transport
I6G72_RS24155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS24170	COG0084	hydrolase, TatD family'
I6G72_RS24175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G72_RS24180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G72_RS24185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G72_RS24210	COG1024	Enoyl-CoA hydratase
I6G72_RS24210	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G72_RS24220	COG2914	Belongs to the UPF0125 (RnfH) family
I6G72_RS24225	COG2867	negative regulation of translational initiation
I6G72_RS24230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G72_RS24250	COG0519	Catalyzes the synthesis of GMP from XMP
I6G72_RS24250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G72_RS24255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G72_RS24255	COG2169	Transcriptional regulator
I6G72_RS24275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G72_RS24280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G72_RS24295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G72_RS24300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G72_RS24305	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6G72_RS24310	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G72_RS24315	COG0750	zinc metalloprotease
I6G72_RS24320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6G72_RS24330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G72_RS24335	COG0233	cytoplasmic translational termination
I6G72_RS24340	COG0528	UMP kinase activity
I6G72_RS24345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G72_RS24350	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G72_RS24355	COG0024	Methionine aminopeptidase
I6G72_RS24360	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6G72_RS24370	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G72_RS24375	COG1451	nucleotide metabolic process
I6G72_RS24395	COG0285	dihydrofolate synthase activity
I6G72_RS24405	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS24410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G72_RS24420	COG1414	Transcriptional regulator
I6G72_RS24425	COG1334	flagellar protein FlaG
I6G72_RS24430	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6G72_RS24450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G72_RS24460	COG1677	Flagellar hook-basal body complex protein FliE
I6G72_RS24465	COG1766	The M ring may be actively involved in energy transduction
I6G72_RS24470	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G72_RS24495	COG1580	Controls the rotational direction of flagella during chemotaxis
I6G72_RS24505	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G72_RS24530	COG0840	transmembrane signaling receptor activity
I6G72_RS24535	COG0840	transmembrane signaling receptor activity
I6G72_RS24545	COG0840	transmembrane signaling receptor activity
I6G72_RS24550	COG0840	transmembrane signaling receptor activity
I6G72_RS24585	COG4787	bacterial-type flagellum-dependent cell motility
I6G72_RS24600	COG1558	bacterial-type flagellum-dependent cell motility
I6G72_RS24605	COG1815	bacterial-type flagellum-dependent cell motility
I6G72_RS24615	COG2747	anti-sigma28 factor FlgM
I6G72_RS24640	COG0840	transmembrane signaling receptor activity
I6G72_RS24645	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6G72_RS24650	COG0745	RESPONSE REGULATOR receiver
I6G72_RS24655	COG2201	protein-glutamate methylesterase activity
I6G72_RS24660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G72_RS24665	COG0840	transmembrane signaling receptor activity
I6G72_RS24670	COG0835	chemotaxis
I6G72_RS24680	COG0745	RESPONSE REGULATOR receiver
I6G72_RS24685	COG1360	Flagellar Motor Protein
I6G72_RS24705	COG1191	sigma factor activity
I6G72_RS24710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G72_RS24710	COG4797	methyltransferase
I6G72_RS24730	COG0583	DNA-binding transcription factor activity
I6G72_RS24740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G72_RS24745	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G72_RS24750	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G72_RS24760	COG4566	intracellular signal transduction
I6G72_RS24765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G72_RS24770	COG0339	signal peptide processing
I6G72_RS24780	COG1999	signal sequence binding
I6G72_RS24805	COG0583	DNA-binding transcription factor activity
I6G72_RS24810	COG1187	pseudouridine synthase activity
I6G72_RS24815	COG3161	chorismate lyase activity
I6G72_RS24820	COG0477	Major facilitator Superfamily
I6G72_RS24835	COG4681	YaeQ
I6G72_RS24840	COG4172	Belongs to the ABC transporter superfamily
I6G72_RS24845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS24850	COG0601	transmembrane transport
I6G72_RS24855	COG0747	negative chemotaxis
I6G72_RS24865	COG0583	DNA-binding transcription factor activity
I6G72_RS24895	COG2165	general secretion pathway protein
I6G72_RS24965	COG0668	transmembrane transport
I6G72_RS24970	COG0165	Argininosuccinate lyase
I6G72_RS24990	COG0022	dehydrogenase e1 component
I6G72_RS25000	COG4774	siderophore transport
I6G72_RS25025	COG0789	Transcriptional regulator
I6G72_RS25035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G72_RS25045	COG2271	Major facilitator Superfamily
I6G72_RS25055	COG0307	riboflavin synthase, alpha
I6G72_RS25060	COG1012	belongs to the aldehyde dehydrogenase family
I6G72_RS25070	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS25090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G72_RS25125	COG0154	amidase activity
I6G72_RS25130	COG2814	Major facilitator Superfamily
I6G72_RS25140	COG2226	methyltransferase
I6G72_RS25165	COG0583	DNA-binding transcription factor activity
I6G72_RS25175	COG0583	DNA-binding transcription factor activity
I6G72_RS25185	COG0583	DNA-binding transcription factor activity
I6G72_RS25190	COG1132	(ABC) transporter
I6G72_RS25220	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS25225	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS25240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G72_RS25250	COG5265	(ABC) transporter
I6G72_RS25255	COG1280	lysine exporter protein (LysE YggA)
I6G72_RS25295	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS25300	COG2188	Transcriptional regulator
I6G72_RS25315	COG0477	Major facilitator Superfamily
I6G72_RS25320	COG0235	Class ii aldolase
I6G72_RS25360	COG2610	gluconate transmembrane transporter activity
I6G72_RS25365	COG0583	DNA-binding transcription factor activity
I6G72_RS25370	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS25375	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6G72_RS25415	COG1024	Enoyl-CoA hydratase
I6G72_RS25420	COG5001	Diguanylate cyclase
I6G72_RS25425	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS25430	COG0129	dihydroxy-acid dehydratase activity
I6G72_RS25440	COG0583	DNA-binding transcription factor activity
I6G72_RS25445	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G72_RS25450	COG3246	L-lysine catabolic process to acetate
I6G72_RS25470	COG3043	anaerobic respiration
I6G72_RS25475	COG3005	denitrification pathway
I6G72_RS25480	COG4133	protoheme IX ABC transporter activity
I6G72_RS25500	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6G72_RS25510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G72_RS25520	COG4235	cytochrome complex assembly
I6G72_RS25540	COG3381	protein complex oligomerization
I6G72_RS25560	COG4133	protoheme IX ABC transporter activity
I6G72_RS25580	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6G72_RS25590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G72_RS25595	COG3088	subunit of a heme lyase
I6G72_RS25615	COG1716	ATPase activity
I6G72_RS25615	COG5001	Diguanylate cyclase
I6G72_RS25630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS25630	COG2205	protein histidine kinase activity
I6G72_RS25635	COG0784	Response regulator, receiver
I6G72_RS25635	COG2198	Histidine kinase
I6G72_RS25635	COG2205	protein histidine kinase activity
I6G72_RS25635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS25645	COG3121	Chaperone
I6G72_RS25675	COG1595	DNA-templated transcription, initiation
I6G72_RS25680	COG3712	iron ion homeostasis
I6G72_RS25700	COG1304	FMN binding
I6G72_RS25710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G72_RS25715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G72_RS25720	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS25725	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS25740	COG2207	Transcriptional regulator
I6G72_RS25775	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS25785	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6G72_RS25790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G72_RS25800	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS25805	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G72_RS25810	COG0534	Mate efflux family protein
I6G72_RS25825	COG0697	spore germination
I6G72_RS25830	COG0697	spore germination
I6G72_RS25845	COG1280	lysine exporter protein (LysE YggA)
I6G72_RS25860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G72_RS25865	COG3245	cytochrome
I6G72_RS25905	COG0318	PFAM AMP-dependent synthetase and ligase
I6G72_RS25910	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS25925	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6G72_RS25930	COG2814	Major facilitator Superfamily
I6G72_RS25945	COG0625	glutathione transferase activity
I6G72_RS25950	COG0583	DNA-binding transcription factor activity
I6G72_RS25955	COG0583	DNA-binding transcription factor activity
I6G72_RS25975	COG0506	proline dehydrogenase activity
I6G72_RS25980	COG0697	spore germination
I6G72_RS25985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G72_RS26015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G72_RS26020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G72_RS26030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6G72_RS26070	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS26075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G72_RS26080	COG1610	YqeY-like protein
I6G72_RS26110	COG0457	Tetratricopeptide repeat
I6G72_RS26115	COG0726	polysaccharide deacetylase
I6G72_RS26115	COG1649	PFAM Uncharacterised BCR, COG1649
I6G72_RS26120	COG1215	transferase activity, transferring glycosyl groups
I6G72_RS26130	COG2223	nitrite transmembrane transporter activity
I6G72_RS26135	COG4977	sequence-specific DNA binding
I6G72_RS26135	COG1917	Cupin 2, conserved barrel domain protein
I6G72_RS26145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G72_RS26160	COG0656	L-ascorbic acid biosynthetic process
I6G72_RS26165	COG5265	(ABC) transporter
I6G72_RS26195	COG1116	anion transmembrane transporter activity
I6G72_RS26220	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS26225	COG0583	DNA-binding transcription factor activity
I6G72_RS26255	COG1522	sequence-specific DNA binding
I6G72_RS26290	COG0456	acetyltransferase
I6G72_RS26295	COG0384	phenazine biosynthesis protein PhzF
I6G72_RS26320	COG2814	Major facilitator Superfamily
I6G72_RS26350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G72_RS26350	COG0072	phenylalanine-tRNA ligase activity
I6G72_RS26355	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G72_RS26360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G72_RS26365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G72_RS26375	COG2960	long-chain fatty acid transporting porin activity
I6G72_RS26385	COG0347	Belongs to the P(II) protein family
I6G72_RS26390	COG0004	ammonium transporteR
I6G72_RS26395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G72_RS26400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G72_RS26415	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6G72_RS26420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G72_RS26430	COG2197	response regulator
I6G72_RS26435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G72_RS26465	COG1012	belongs to the aldehyde dehydrogenase family
I6G72_RS26475	COG0601	transmembrane transport
I6G72_RS26480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G72_RS26485	COG4172	Belongs to the ABC transporter superfamily
I6G72_RS26505	COG1609	Transcriptional regulator
I6G72_RS26510	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6G72_RS26515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6G72_RS26520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G72_RS26525	COG0129	dihydroxy-acid dehydratase activity
I6G72_RS26560	COG0596	Alpha beta hydrolase
I6G72_RS26580	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6G72_RS26585	COG0101	tRNA pseudouridine synthase activity
I6G72_RS26595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G72_RS26615	COG1538	Outer membrane efflux protein
I6G72_RS26630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G72_RS26680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6G72_RS26705	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6G72_RS26715	COG1295	ribonuclease BN
I6G72_RS26725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G72_RS26755	COG4964	Belongs to the GSP D family
I6G72_RS26785	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6G72_RS26785	COG2755	lipolytic protein G-D-S-L family
I6G72_RS26795	COG0438	transferase activity, transferring glycosyl groups
I6G72_RS26815	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G72_RS26820	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6G72_RS26825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G72_RS26830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6G72_RS26835	COG0330	HflC and HflK could
I6G72_RS26840	COG0330	HflC and HflK could
I6G72_RS26845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G72_RS26850	COG1923	regulation of RNA biosynthetic process
I6G72_RS26855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G72_RS26860	COG1160	GTP binding
I6G72_RS26865	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G72_RS26870	COG2976	Protein conserved in bacteria
I6G72_RS26895	COG0105	UTP biosynthetic process
I6G72_RS26900	COG0525	valine-tRNA ligase activity
I6G72_RS26905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G72_RS26910	COG1126	abc transporter atp-binding protein
I6G72_RS26915	COG0765	amino acid transport
I6G72_RS26920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G72_RS26925	COG1396	sequence-specific DNA binding
I6G72_RS26930	COG0336	Belongs to the RNA methyltransferase TrmD family
I6G72_RS26940	COG0228	four-way junction DNA binding
I6G72_RS26950	COG0425	Belongs to the sulfur carrier protein TusA family
I6G72_RS26955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G72_RS26970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G72_RS26985	COG2076	Multidrug Resistance protein
I6G72_RS26990	COG0633	Ferredoxin
I6G72_RS26990	COG3217	Mosc domain protein beta barrel domain protein
I6G72_RS26995	COG5285	phytanoyl-CoA dioxygenase
I6G72_RS27000	COG0662	Cupin 2, conserved barrel domain protein
I6G72_RS27025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G72_RS27030	COG2311	Membrane
I6G72_RS27035	COG1309	transcriptional regulator
I6G72_RS27060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G72_RS27070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G72_RS27075	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G72_RS27095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G72_RS27105	COG3391	amine dehydrogenase activity
I6G72_RS27135	COG1846	Transcriptional regulator
I6G72_RS27145	COG1566	PFAM secretion protein HlyD family protein
I6G72_RS27150	COG2814	Major facilitator Superfamily
I6G72_RS27160	COG0473	3-isopropylmalate dehydrogenase activity
I6G72_RS27165	COG0433	COG0433 Predicted ATPase
I6G72_RS27170	COG0217	transcriptional regulatory protein
I6G72_RS27175	COG0151	Belongs to the GarS family
I6G72_RS27185	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G72_RS27190	COG0799	negative regulation of ribosome biogenesis
I6G72_RS27195	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6G72_RS27205	COG1301	dicarboxylic acid transport
I6G72_RS27210	COG4191	Histidine kinase
I6G72_RS27215	COG2204	response regulator
I6G72_RS27245	COG1530	ribonuclease E activity
I6G72_RS27255	COG5001	Diguanylate cyclase
I6G72_RS27255	COG4251	negative regulation of phosphorylation
I6G72_RS27255	COG2203	Gaf domain
I6G72_RS27255	COG3706	GGDEF domain
I6G72_RS27265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G72_RS27265	COG0475	glutathione-regulated potassium exporter activity
I6G72_RS27270	COG1132	(ABC) transporter
I6G72_RS27295	COG0726	polysaccharide deacetylase
I6G72_RS27310	COG0726	polysaccharide deacetylase
I6G72_RS27315	COG0438	transferase activity, transferring glycosyl groups
I6G72_RS27330	COG1116	anion transmembrane transporter activity
I6G72_RS27335	COG0395	ABC-type sugar transport system, permease component
I6G72_RS27340	COG1643	Atp-dependent helicase
I6G72_RS27345	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G72_RS27345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G72_RS27350	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6G72_RS27360	COG0704	Plays a role in the regulation of phosphate uptake
I6G72_RS27370	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS27380	COG1322	Protein conserved in bacteria
I6G72_RS27400	COG1177	transmembrane transport
I6G72_RS27405	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G72_RS27410	COG3842	ATPase activity
I6G72_RS27420	COG3642	lipopolysaccharide core region biosynthetic process
I6G72_RS27430	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G72_RS27435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G72_RS27445	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6G72_RS27445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6G72_RS27455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G72_RS27460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G72_RS27465	COG0596	Alpha beta hydrolase
I6G72_RS27465	COG2945	thiolester hydrolase activity
I6G72_RS27485	COG3618	amidohydrolase
I6G72_RS27490	COG0583	DNA-binding transcription factor activity
I6G72_RS27495	COG0137	argininosuccinate synthase activity
I6G72_RS27500	COG3158	transport of potassium into the cell
I6G72_RS27505	COG0642	Histidine kinase
I6G72_RS27535	COG0776	regulation of translation
I6G72_RS27540	COG3128	pkhd-type hydroxylase
I6G72_RS27550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G72_RS27555	COG0557	exoribonuclease II activity
I6G72_RS27585	COG0679	Auxin Efflux Carrier
I6G72_RS27590	COG2391	methyltransferase activity
I6G72_RS27595	COG0069	glutamate synthase activity
I6G72_RS27600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G72_RS27610	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6G72_RS27645	COG0697	spore germination
I6G72_RS27760	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6G72_RS27770	COG0628	permease
I6G72_RS27800	COG3909	cytochrome
I6G72_RS27810	COG0625	glutathione transferase activity
I6G72_RS27815	COG0730	response to heat
I6G72_RS27820	COG0482	sulfurtransferase activity
I6G72_RS27825	COG0583	DNA-binding transcription factor activity
I6G72_RS27855	COG0247	lactate metabolic process
I6G72_RS27860	COG0277	FAD linked oxidase domain protein
I6G72_RS27865	COG0277	FAD linked oxidase domain protein
I6G72_RS27870	COG0277	FAD linked oxidase domain protein
I6G72_RS27875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G72_RS27880	COG0312	modulator of DNA gyrase
I6G72_RS27895	COG0308	aminopeptidase N
I6G72_RS27900	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6G72_RS27920	COG0436	Aminotransferase
I6G72_RS27930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G72_RS27935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6G72_RS27955	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G72_RS27985	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS27995	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6G72_RS28015	COG0181	hydroxymethylbilane synthase activity
I6G72_RS28020	COG0861	Integral membrane protein TerC family
I6G72_RS28025	COG0861	Integral membrane protein TerC family
I6G72_RS28030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G72_RS28035	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G72_RS28060	COG2137	regulation of response to DNA damage stimulus
I6G72_RS28065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G72_RS28100	COG0540	Belongs to the ATCase OTCase family
I6G72_RS28150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G72_RS28185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G72_RS28195	COG0305	Participates in initiation and elongation during chromosome replication
I6G72_RS28205	COG0359	binds to the 23S rRNA
I6G72_RS28210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G72_RS28215	COG2965	DNA replication, synthesis of RNA primer
I6G72_RS28220	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G72_RS28225	COG3739	integral membrane protein
I6G72_RS28230	COG1469	GTP cyclohydrolase I activity
I6G72_RS28240	COG0142	geranyltranstransferase activity
I6G72_RS28245	COG1722	exodeoxyribonuclease VII activity
I6G72_RS28255	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS28275	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G72_RS28280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G72_RS28290	COG3842	ATPase activity
I6G72_RS28295	COG0583	DNA-binding transcription factor activity
I6G72_RS28315	COG0501	Belongs to the peptidase M48B family
I6G72_RS28320	COG1760	l-serine dehydratase
I6G72_RS28330	COG0412	Dienelactone hydrolase
I6G72_RS28345	COG1611	Belongs to the LOG family
I6G72_RS28350	COG1473	amidohydrolase
I6G72_RS28355	COG3181	Tripartite tricarboxylate transporter family receptor
I6G72_RS28375	COG1217	gtp-binding protein TYPA
I6G72_RS28380	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G72_RS28385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G72_RS28390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G72_RS28395	COG0195	Participates in both transcription termination and antitermination
I6G72_RS28395	COG2251	uridine kinase activity
I6G72_RS28400	COG0779	Required for maturation of 30S ribosomal subunits
I6G72_RS28405	COG1187	pseudouridine synthase activity
I6G72_RS28410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G72_RS28425	COG0583	DNA-binding transcription factor activity
I6G72_RS28430	COG0523	cobalamin synthesis protein
I6G72_RS28435	COG0523	cobalamin synthesis protein
I6G72_RS28455	COG0642	Histidine kinase
I6G72_RS28460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G72_RS28465	COG0625	glutathione transferase activity
I6G72_RS28470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G72_RS28480	COG2003	Belongs to the UPF0758 family
I6G72_RS28485	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6G72_RS28490	COG3483	tryptophan 2,3-dioxygenase activity
I6G72_RS28505	COG0534	Mate efflux family protein
I6G72_RS28515	COG2050	protein possibly involved in aromatic compounds catabolism
I6G72_RS28520	COG1024	Enoyl-CoA hydratase
I6G72_RS28525	COG1012	belongs to the aldehyde dehydrogenase family
I6G72_RS28530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G72_RS28535	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G72_RS28540	COG3396	Phenylacetate-CoA oxygenase
I6G72_RS28545	COG3460	Phenylacetate-CoA oxygenase
I6G72_RS28550	COG3396	Phenylacetate-CoA oxygenase
I6G72_RS28555	COG3327	negative regulation of DNA-templated transcription, initiation
I6G72_RS28560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G72_RS28565	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6G72_RS28570	COG0501	Belongs to the peptidase M48B family
I6G72_RS28575	COG1162	GTPase activity
I6G72_RS28580	COG0494	nUDIX hydrolase
I6G72_RS28585	COG0335	large ribosomal subunit rRNA binding
I6G72_RS28620	COG4208	sulfate ABC transporter
I6G72_RS28625	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6G72_RS28635	COG0450	alkyl hydroperoxide reductase
I6G72_RS28640	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS28645	COG2985	domain, Protein
I6G72_RS28670	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6G72_RS28675	COG2951	lytic endotransglycosylase activity
I6G72_RS28705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G72_RS28710	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G72_RS28715	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6G72_RS28735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G72_RS28740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G72_RS28750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G72_RS28760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6G72_RS28775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G72_RS28800	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G72_RS28810	COG1215	transferase activity, transferring glycosyl groups
I6G72_RS28830	COG1696	Membrane protein involved in D-alanine export
I6G72_RS28840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G72_RS28850	COG1960	acyl-CoA dehydrogenase activity
I6G72_RS28865	COG2951	lytic endotransglycosylase activity
I6G72_RS28870	COG2258	MOSC domain
I6G72_RS28875	COG2833	Protein of unknown function (DUF455)
I6G72_RS28890	COG1132	(ABC) transporter
I6G72_RS28895	COG0189	ligase activity
I6G72_RS28895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G72_RS28900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G72_RS28900	COG0189	ligase activity
I6G72_RS28905	COG3237	CsbD-like
I6G72_RS28915	COG2823	Periplasmic or secreted lipoprotein
I6G72_RS28935	COG3210	domain, Protein
I6G72_RS28940	COG2831	hemolysin activation secretion protein
I6G72_RS28965	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
I6G72_RS28970	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS28975	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6G72_RS28980	COG1496	oxidoreductase activity
I6G72_RS28985	COG0564	pseudouridine synthase activity
I6G72_RS28995	COG1199	ATP-dependent helicase activity
I6G72_RS29000	COG2183	response to ionizing radiation
I6G72_RS29035	COG4774	siderophore transport
I6G72_RS29040	COG3712	iron ion homeostasis
I6G72_RS29045	COG1595	DNA-templated transcription, initiation
I6G72_RS29050	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G72_RS29055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G72_RS29060	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G72_RS29065	COG0567	Dehydrogenase, E1 component
I6G72_RS29070	COG1522	sequence-specific DNA binding
I6G72_RS29075	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6G72_RS29090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G72_RS29095	COG1297	OPT oligopeptide transporter protein
I6G72_RS29105	COG0281	malic enzyme
I6G72_RS29105	COG0280	phosphate acetyltransferase
I6G72_RS29120	COG0372	Belongs to the citrate synthase family
I6G72_RS29125	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6G72_RS29130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G72_RS29135	COG1053	succinate dehydrogenase
I6G72_RS29140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G72_RS29145	COG2009	succinate dehydrogenase
I6G72_RS29150	COG2188	Transcriptional regulator
I6G72_RS29155	COG0039	L-malate dehydrogenase activity
I6G72_RS29175	COG1981	membrane
I6G72_RS29210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G72_RS29220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G72_RS29235	COG0148	phosphopyruvate hydratase activity
I6G72_RS29245	COG0504	CTP synthase activity
I6G72_RS29280	COG0747	negative chemotaxis
I6G72_RS29285	COG4172	Belongs to the ABC transporter superfamily
I6G72_RS29290	COG1446	asparaginase
I6G72_RS29300	COG2153	protein acetylation
I6G72_RS29325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G72_RS29345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G72_RS29350	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6G72_RS29355	COG0697	spore germination
I6G72_RS29360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G72_RS29370	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6G72_RS29380	COG0791	NLP P60 protein
I6G72_RS29390	COG0583	DNA-binding transcription factor activity
I6G72_RS29415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G72_RS29465	COG1381	Involved in DNA repair and RecF pathway recombination
I6G72_RS29470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G72_RS29475	COG0571	ribonuclease III activity
I6G72_RS29480	COG0681	Belongs to the peptidase S26 family
I6G72_RS29485	COG0481	GTPase activity
I6G72_RS29490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G72_RS29515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G72_RS29520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G72_RS29530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G72_RS29535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G72_RS29545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G72_RS29555	COG0424	maF-like protein
I6G72_RS29570	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6G72_RS29575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G72_RS29580	COG0546	phosphoglycolate phosphatase activity
I6G72_RS29585	COG0564	pseudouridine synthase activity
I6G72_RS29590	COG1530	ribonuclease E activity
I6G72_RS29595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6G72_RS29600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G72_RS29605	COG0159	tryptophan synthase activity
I6G72_RS29615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G72_RS29625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G72_RS29630	COG3228	Belongs to the MtfA family
I6G72_RS29640	COG0251	oxidation-reduction process
I6G72_RS29645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G72_RS29650	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6G72_RS29665	COG2878	Part of a membrane complex involved in electron transport
I6G72_RS29670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G72_RS29705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G72_RS29740	COG1268	BioY protein
I6G72_RS29745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6G72_RS29750	COG1122	ATPase activity
I6G72_RS29755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G72_RS29760	COG2917	probably involved in intracellular septation
I6G72_RS29770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G72_RS29775	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G72_RS29785	COG1196	nuclear chromosome segregation
I6G72_RS29790	COG0477	Major facilitator Superfamily
I6G72_RS29795	COG1573	uracil-dna glycosylase
I6G72_RS29800	COG1214	PFAM Peptidase M22, glycoprotease
I6G72_RS29815	COG0450	alkyl hydroperoxide reductase
I6G72_RS29820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G72_RS29830	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6G72_RS29835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6G72_RS29840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G72_RS29845	COG0560	Phosphoserine phosphatase
I6G72_RS29850	COG4774	siderophore transport
I6G72_RS29855	COG4774	siderophore transport
I6G72_RS29865	COG1007	ATP synthesis coupled electron transport
I6G72_RS29880	COG0713	ATP synthesis coupled electron transport
I6G72_RS29890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G72_RS29895	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6G72_RS29900	COG1034	ATP synthesis coupled electron transport
I6G72_RS29910	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6G72_RS29915	COG0649	NAD binding
I6G72_RS29920	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G72_RS29925	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G72_RS29930	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G72_RS29935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G72_RS29960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G72_RS29980	COG0583	DNA-binding transcription factor activity
I6G72_RS29985	COG1309	transcriptional regulator
I6G72_RS29995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G72_RS30015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G72_RS30020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G72_RS30025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G72_RS30035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G72_RS30040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G72_RS30060	COG0747	negative chemotaxis
I6G72_RS30070	COG4172	Belongs to the ABC transporter superfamily
I6G72_RS30090	COG1522	sequence-specific DNA binding
I6G72_RS30095	COG4772	TonB-dependent receptor
I6G72_RS30100	COG2354	Protein conserved in bacteria
I6G72_RS30105	COG3813	Protein conserved in bacteria
I6G72_RS30110	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6G72_RS30115	COG3604	Transcriptional regulator
I6G72_RS30130	COG0784	Response regulator, receiver
I6G72_RS30130	COG4191	Histidine kinase
I6G72_RS30135	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G72_RS30155	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS30160	COG2851	Citrate transporter
I6G72_RS30170	COG0642	Histidine kinase
I6G72_RS30190	COG3712	iron ion homeostasis
I6G72_RS30195	COG1595	DNA-templated transcription, initiation
I6G72_RS30210	COG1116	anion transmembrane transporter activity
I6G72_RS30245	COG1910	domain protein
I6G72_RS30265	COG0840	transmembrane signaling receptor activity
I6G72_RS30290	COG3047	cAMP biosynthetic process
I6G72_RS30290	COG2885	chlorophyll binding
I6G72_RS30305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G72_RS30310	COG0149	triose-phosphate isomerase activity
I6G72_RS30335	COG2207	Transcriptional regulator
I6G72_RS30355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G72_RS30365	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G72_RS30370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G72_RS30380	COG1183	phosphatidylcholine synthase activity
I6G72_RS30385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G72_RS30390	COG0440	acetolactate synthase activity
I6G72_RS30395	COG0028	Belongs to the TPP enzyme family
I6G72_RS30400	COG1289	transmembrane transporter activity
I6G72_RS30405	COG3022	response to hydroperoxide
I6G72_RS30410	COG1028	Short-chain dehydrogenase reductase Sdr
I6G72_RS30430	COG1132	(ABC) transporter
I6G72_RS30430	COG2375	cellular response to nickel ion
I6G72_RS30435	COG1132	(ABC) transporter
I6G72_RS30440	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G72_RS30445	COG4605	iron ion homeostasis
I6G72_RS30450	COG4604	ABC transporter, ATP-binding protein
I6G72_RS30455	COG4607	ABC-type enterochelin transport system periplasmic component
I6G72_RS30460	COG4774	siderophore transport
I6G72_RS30470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G72_RS30510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G72_RS30515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G72_RS30520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G72_RS30535	COG0601	transmembrane transport
I6G72_RS30555	COG0517	IMP dehydrogenase activity
I6G72_RS30555	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G72_RS30560	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6G72_RS30565	COG0251	oxidation-reduction process
I6G72_RS30570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G72_RS30575	COG1674	ftsk spoiiie
I6G72_RS30580	COG0492	ferredoxin-NADP+ reductase activity
I6G72_RS30585	COG1193	negative regulation of DNA recombination
I6G72_RS30595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G72_RS30610	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6G72_RS30615	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6G72_RS30620	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6G72_RS30625	COG2205	protein histidine kinase activity
I6G72_RS30630	COG0745	RESPONSE REGULATOR receiver
I6G72_RS30645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G72_RS30650	COG0840	transmembrane signaling receptor activity
I6G72_RS30685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G72_RS30710	COG0612	Peptidase, M16
I6G72_RS30720	COG0484	heat shock protein binding
I6G72_RS30725	COG0443	Heat shock 70 kDa protein
I6G72_RS30735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G72_RS30745	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G72_RS30750	COG1420	regulation of RNA biosynthetic process
I6G72_RS30760	COG0497	DNA recombination
I6G72_RS30765	COG0735	belongs to the Fur family
I6G72_RS30770	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G72_RS30795	COG0582	viral genome integration into host DNA
I6G72_RS30800	COG0583	DNA-binding transcription factor activity
I6G72_RS30810	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6G72_RS30830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G72_RS30830	COG2226	methyltransferase
I6G72_RS30830	COG3433	isochorismatase activity
I6G72_RS30870	COG4106	trans-aconitate 2-methyltransferase activity
I6G72_RS30880	COG2814	Major facilitator Superfamily
I6G72_RS30885	COG2375	cellular response to nickel ion
I6G72_RS30885	COG1132	(ABC) transporter
I6G72_RS30895	COG4771	TonB-dependent receptor
I6G72_RS30925	COG0640	Transcriptional regulator
I6G72_RS30930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G72_RS30990	COG4774	siderophore transport
I6G72_RS31000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G72_RS31005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G72_RS31020	COG0019	diaminopimelate decarboxylase activity
I6G72_RS31030	COG1131	(ABC) transporter
I6G72_RS31060	COG4771	TonB-dependent receptor
I6G72_RS31075	COG2807	transmembrane transport
I6G72_RS31095	COG0024	Methionine aminopeptidase
I6G72_RS31110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G72_RS31225	COG3311	Transcriptional regulator
I6G72_RS31230	COG1569	PIN domain
I6G72_RS31235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G72_RS31330	COG3344	reverse transcriptase
I6G72_RS31355	COG3344	reverse transcriptase