locus-tag	class	description
HPS43_RS00035	COG1396	sequence-specific DNA binding
HPS43_RS00040	COG0235	Class ii aldolase
HPS43_RS00050	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS00070	COG3436	PFAM IS66 Orf2 family protein
HPS43_RS00135	COG3468	outer membrane autotransporter barrel domain protein
HPS43_RS00195	COG1024	Enoyl-CoA hydratase
HPS43_RS00210	COG0583	DNA-binding transcription factor activity
HPS43_RS00265	COG3384	dioxygenase
HPS43_RS00310	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS43_RS00315	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPS43_RS00320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS43_RS00335	COG1609	Transcriptional regulator
HPS43_RS00340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_RS00345	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS43_RS00355	COG1850	ribulose-bisphosphate carboxylase activity
HPS43_RS00370	COG0505	Belongs to the CarA family
HPS43_RS00390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPS43_RS00390	COG3608	succinylglutamate desuccinylase aspartoacylase
HPS43_RS00395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPS43_RS00410	COG2207	Transcriptional regulator
HPS43_RS00415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS00485	COG0668	transmembrane transport
HPS43_RS00495	COG0166	Belongs to the GPI family
HPS43_RS00525	COG0387	Pfam Sodium calcium exchanger
HPS43_RS00530	COG3568	Endonuclease Exonuclease Phosphatase
HPS43_RS00535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS43_RS00540	COG0392	lysyltransferase activity
HPS43_RS00545	COG0297	glycogen (starch) synthase activity
HPS43_RS00550	COG0366	Alpha amylase catalytic
HPS43_RS00555	COG0366	Alpha amylase catalytic
HPS43_RS00570	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPS43_RS00575	COG1640	4-alpha-glucanotransferase
HPS43_RS00585	COG1113	amino acid transport
HPS43_RS00610	COG1546	Belongs to the CinA family
HPS43_RS00610	COG1058	Belongs to the CinA family
HPS43_RS00620	COG3852	Histidine kinase
HPS43_RS00640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS43_RS00650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS43_RS00660	COG0477	Major facilitator Superfamily
HPS43_RS00675	COG4771	TonB-dependent receptor
HPS43_RS00740	COG2188	Transcriptional regulator
HPS43_RS00760	COG1414	Transcriptional regulator
HPS43_RS00765	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS43_RS00770	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS00780	COG2721	sulfolactate sulfo-lyase activity
HPS43_RS00790	COG0765	amino acid transport
HPS43_RS00805	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_RS00815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS43_RS00820	COG3958	Transketolase
HPS43_RS00825	COG3959	Transketolase, thiamine diphosphate binding domain
HPS43_RS00830	COG1802	Transcriptional regulator
HPS43_RS00835	COG0371	Dehydrogenase
HPS43_RS00840	COG3246	L-lysine catabolic process to acetate
HPS43_RS00850	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS00860	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_RS00875	COG0604	alcohol dehydrogenase
HPS43_RS00875	COG3321	synthase
HPS43_RS00875	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS00910	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS00915	COG0583	DNA-binding transcription factor activity
HPS43_RS00920	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPS43_RS00945	COG2814	Major facilitator Superfamily
HPS43_RS00960	COG3384	dioxygenase
HPS43_RS00975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPS43_RS01030	COG4964	Belongs to the GSP D family
HPS43_RS01075	COG1846	Transcriptional regulator
HPS43_RS01080	COG4172	Belongs to the ABC transporter superfamily
HPS43_RS01085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_RS01090	COG0601	transmembrane transport
HPS43_RS01105	COG0598	Magnesium transport protein CorA
HPS43_RS01125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS43_RS01140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPS43_RS01145	COG1045	serine acetyltransferase
HPS43_RS01150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPS43_RS01155	COG0166	Belongs to the GPI family
HPS43_RS01160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPS43_RS01165	COG0489	protein tyrosine kinase activity
HPS43_RS01165	COG3206	protein involved in exopolysaccharide biosynthesis
HPS43_RS01170	COG1596	polysaccharide export
HPS43_RS01180	COG1051	belongs to the nudix hydrolase family
HPS43_RS01200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_RS01225	COG0463	Glycosyl transferase, family 2
HPS43_RS01230	COG0110	maltose O-acetyltransferase activity
HPS43_RS01235	COG0297	glycogen (starch) synthase activity
HPS43_RS01240	COG2197	response regulator
HPS43_RS01245	COG2197	response regulator
HPS43_RS01255	COG1309	transcriptional regulator
HPS43_RS01260	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS01270	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_RS01270	COG1024	Enoyl-CoA hydratase
HPS43_RS01280	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_RS01280	COG1024	Enoyl-CoA hydratase
HPS43_RS01285	COG0183	Belongs to the thiolase family
HPS43_RS01300	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS01310	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS01320	COG1132	(ABC) transporter
HPS43_RS01330	COG3395	kinase activity
HPS43_RS01335	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS43_RS01345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS43_RS01350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPS43_RS01355	COG1024	Enoyl-CoA hydratase
HPS43_RS01365	COG1414	Transcriptional regulator
HPS43_RS01375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPS43_RS01395	COG0583	DNA-binding transcription factor activity
HPS43_RS01425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPS43_RS01430	COG1309	transcriptional regulator
HPS43_RS01440	COG1051	belongs to the nudix hydrolase family
HPS43_RS01445	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HPS43_RS01455	COG0784	Response regulator, receiver
HPS43_RS01455	COG2205	protein histidine kinase activity
HPS43_RS01465	COG0784	Response regulator, receiver
HPS43_RS01465	COG2205	protein histidine kinase activity
HPS43_RS01485	COG3258	Cytochrome c
HPS43_RS01500	COG3278	Belongs to the heme-copper respiratory oxidase family
HPS43_RS01520	COG0348	domain, Protein
HPS43_RS01535	COG0527	aspartate kinase activity
HPS43_RS01540	COG0037	tRNA processing
HPS43_RS01545	COG0825	malonyl-CoA metabolic process
HPS43_RS01555	COG0215	cysteine-tRNA ligase activity
HPS43_RS01570	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPS43_RS01575	COG1968	undecaprenyl-diphosphatase activity
HPS43_RS01580	COG1253	flavin adenine dinucleotide binding
HPS43_RS01595	COG4263	nitrous-oxide reductase activity
HPS43_RS01610	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPS43_RS01620	COG1477	protein flavinylation
HPS43_RS01625	COG4804	nuclease activity
HPS43_RS01650	COG0668	transmembrane transport
HPS43_RS01690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS43_RS01695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_RS01700	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS43_RS01735	COG0300	oxidoreductase activity
HPS43_RS01745	COG3360	Dodecin
HPS43_RS01755	COG0583	DNA-binding transcription factor activity
HPS43_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS01820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPS43_RS01825	COG2850	peptidyl-arginine hydroxylation
HPS43_RS01835	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPS43_RS01840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_RS01845	COG1994	Peptidase M50
HPS43_RS01850	COG0009	L-threonylcarbamoyladenylate synthase
HPS43_RS01855	COG2321	neutral zinc metallopeptidase
HPS43_RS01915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS43_RS01920	COG3969	phosphoadenosine phosphosulfate
HPS43_RS01930	COG1475	DNA binding
HPS43_RS01935	COG0642	Histidine kinase
HPS43_RS01960	COG3188	usher protein
HPS43_RS01965	COG3121	Chaperone
HPS43_RS01970	COG0840	transmembrane signaling receptor activity
HPS43_RS02005	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS02010	COG3387	PFAM Glycoside hydrolase 15-related
HPS43_RS02025	COG0840	transmembrane signaling receptor activity
HPS43_RS02030	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS02035	COG1280	lysine exporter protein (LysE YggA)
HPS43_RS02050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS43_RS02060	COG2207	Transcriptional regulator
HPS43_RS02060	COG1917	Cupin 2, conserved barrel domain protein
HPS43_RS02070	COG2084	Dehydrogenase
HPS43_RS02085	COG1802	Transcriptional regulator
HPS43_RS02100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_RS02125	COG0745	RESPONSE REGULATOR receiver
HPS43_RS02130	COG2205	protein histidine kinase activity
HPS43_RS02135	COG1764	response to oxidative stress
HPS43_RS02150	COG0586	Pfam SNARE associated Golgi protein
HPS43_RS02155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS02160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPS43_RS02220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_RS02225	COG0765	amino acid transport
HPS43_RS02235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS02245	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_RS02270	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS02295	COG0348	domain, Protein
HPS43_RS02315	COG3278	Belongs to the heme-copper respiratory oxidase family
HPS43_RS02330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPS43_RS02335	COG0156	8-amino-7-oxononanoate synthase activity
HPS43_RS02360	COG2224	Isocitrate lyase
HPS43_RS02365	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPS43_RS02365	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPS43_RS02370	COG1858	cytochrome C peroxidase
HPS43_RS02375	COG0583	DNA-binding transcription factor activity
HPS43_RS02380	COG0473	3-isopropylmalate dehydrogenase activity
HPS43_RS02390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPS43_RS02405	COG0736	holo-[acyl-carrier-protein] synthase activity
HPS43_RS02410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPS43_RS02420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_RS02425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_RS02450	COG3842	ATPase activity
HPS43_RS02455	COG4149	molybdate abc transporter
HPS43_RS02460	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPS43_RS02465	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPS43_RS02490	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPS43_RS02500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_RS02510	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPS43_RS02520	COG0667	Aldo Keto reductase
HPS43_RS02530	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS02535	COG1024	Enoyl-CoA hydratase
HPS43_RS02545	COG1802	Transcriptional regulator
HPS43_RS02555	COG0183	Belongs to the thiolase family
HPS43_RS02560	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS02565	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS02570	COG0583	DNA-binding transcription factor activity
HPS43_RS02595	COG4213	ABC transporter substrate-binding protein
HPS43_RS02600	COG1129	ABC transporter
HPS43_RS02605	COG4214	carbohydrate transport
HPS43_RS02610	COG2706	6-phosphogluconolactonase activity
HPS43_RS02615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_RS02630	COG3448	diguanylate cyclase activity
HPS43_RS02630	COG4175	Glycine betaine
HPS43_RS02635	COG4176	ABC-type proline glycine betaine transport system permease component
HPS43_RS02645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS43_RS02650	COG2814	Major facilitator Superfamily
HPS43_RS02655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPS43_RS02660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPS43_RS02695	COG1686	Belongs to the peptidase S11 family
HPS43_RS02705	COG1846	Transcriptional regulator
HPS43_RS02710	COG2814	Major facilitator Superfamily
HPS43_RS02715	COG0495	leucyl-tRNA aminoacylation
HPS43_RS02730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPS43_RS02760	COG0477	Major facilitator Superfamily
HPS43_RS02770	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_RS02785	COG0583	DNA-binding transcription factor activity
HPS43_RS02835	COG0583	DNA-binding transcription factor activity
HPS43_RS02840	COG0427	acetyl-CoA hydrolase
HPS43_RS02845	COG0583	DNA-binding transcription factor activity
HPS43_RS02850	COG3264	Mechanosensitive ion channel
HPS43_RS02850	COG1511	domain protein
HPS43_RS02900	COG3842	ATPase activity
HPS43_RS02905	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS43_RS02910	COG1177	transmembrane transport
HPS43_RS02915	COG3938	Belongs to the proline racemase family
HPS43_RS02930	COG0517	IMP dehydrogenase activity
HPS43_RS02960	COG0500	methyltransferase
HPS43_RS02975	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HPS43_RS02990	COG0667	Aldo Keto reductase
HPS43_RS02995	COG2207	Transcriptional regulator
HPS43_RS03000	COG0583	DNA-binding transcription factor activity
HPS43_RS03005	COG1335	isochorismatase
HPS43_RS03015	COG2841	Protein conserved in bacteria
HPS43_RS03030	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS43_RS03035	COG0438	transferase activity, transferring glycosyl groups
HPS43_RS03105	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPS43_RS03130	COG2814	Major facilitator Superfamily
HPS43_RS03135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPS43_RS03160	COG0248	Ppx GppA phosphatase
HPS43_RS03170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPS43_RS03180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPS43_RS03185	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPS43_RS03190	COG1534	Rna-binding protein
HPS43_RS03195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPS43_RS03200	COG0840	transmembrane signaling receptor activity
HPS43_RS03205	COG2233	PERMEase
HPS43_RS03225	COG3842	ATPase activity
HPS43_RS03240	COG4221	oxidoreductase activity
HPS43_RS03250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPS43_RS03255	COG0505	Belongs to the CarA family
HPS43_RS03275	COG0745	RESPONSE REGULATOR receiver
HPS43_RS03290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_RS03300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS43_RS03305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_RS03320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPS43_RS03330	COG1074	ATP-dependent DNA helicase activity
HPS43_RS03350	COG2070	2-Nitropropane dioxygenase
HPS43_RS03370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_RS03385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS43_RS03390	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS03405	COG1686	Belongs to the peptidase S11 family
HPS43_RS03420	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HPS43_RS03425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPS43_RS03430	COG4974	Belongs to the 'phage' integrase family
HPS43_RS03435	COG0583	DNA-binding transcription factor activity
HPS43_RS03440	COG0028	Belongs to the TPP enzyme family
HPS43_RS03485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPS43_RS03530	COG0028	Belongs to the TPP enzyme family
HPS43_RS03535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS03550	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS43_RS03555	COG1414	Transcriptional regulator
HPS43_RS03560	COG0009	L-threonylcarbamoyladenylate synthase
HPS43_RS03565	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPS43_RS03570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPS43_RS03575	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPS43_RS03585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPS43_RS03605	COG1301	dicarboxylic acid transport
HPS43_RS03615	COG3454	Phosphonate metabolism
HPS43_RS03620	COG4778	phosphonate C-P lyase system protein PhnL
HPS43_RS03625	COG4107	phosphonate C-P lyase system protein PhnK
HPS43_RS03630	COG3627	carbon phosphorus lyase activity
HPS43_RS03635	COG3626	phosphonate metabolism
HPS43_RS03640	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HPS43_RS03645	COG3624	Phosphonate C-P lyase system protein PhnG
HPS43_RS03650	COG2188	Transcriptional regulator
HPS43_RS03655	COG3454	Phosphonate metabolism
HPS43_RS03660	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HPS43_RS03665	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HPS43_RS03670	COG0583	DNA-binding transcription factor activity
HPS43_RS03675	COG0405	Gamma-glutamyltransferase
HPS43_RS03690	COG3639	organic phosphonate transmembrane transporter activity
HPS43_RS03695	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HPS43_RS03700	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HPS43_RS03710	COG0640	Transcriptional regulator
HPS43_RS03720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPS43_RS03730	COG0739	heme binding
HPS43_RS03740	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPS43_RS03750	COG0306	phosphate transporter
HPS43_RS03785	COG0625	glutathione transferase activity
HPS43_RS03805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPS43_RS03810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPS43_RS03825	COG0126	phosphoglycerate kinase activity
HPS43_RS03830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPS43_RS03835	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPS43_RS03845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPS43_RS03850	COG2732	(Barnase) inhibitor
HPS43_RS03860	COG0280	phosphate acetyltransferase
HPS43_RS03860	COG0281	malic enzyme
HPS43_RS03895	COG0753	catalase activity
HPS43_RS03905	COG0741	lytic transglycosylase activity
HPS43_RS03910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPS43_RS03925	COG4575	ribosome binding
HPS43_RS03935	COG1116	anion transmembrane transporter activity
HPS43_RS03940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_RS03945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS43_RS03950	COG1648	precorrin-2 dehydrogenase activity
HPS43_RS03950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPS43_RS03955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPS43_RS03960	COG2027	D-alanyl-D-alanine carboxypeptidase
HPS43_RS03975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_RS03985	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPS43_RS03990	COG0343	queuine tRNA-ribosyltransferase activity
HPS43_RS04000	COG3077	Addiction module antitoxin, RelB DinJ family
HPS43_RS04005	COG1862	Preprotein translocase
HPS43_RS04010	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS43_RS04015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS43_RS04035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPS43_RS04045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPS43_RS04050	COG1702	phosphate starvation-inducible protein PhoH
HPS43_RS04055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPS43_RS04060	COG4535	Mg2 and Co2 transporter CorC
HPS43_RS04065	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPS43_RS04070	COG0667	Aldo Keto reductase
HPS43_RS04115	COG0697	spore germination
HPS43_RS04125	COG0678	peroxiredoxin activity
HPS43_RS04135	COG0412	Dienelactone hydrolase
HPS43_RS04145	COG0315	cyclic pyranopterin monophosphate synthase activity
HPS43_RS04155	COG0314	molybdopterin synthase activity
HPS43_RS04160	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPS43_RS04165	COG0303	'Molybdopterin
HPS43_RS04175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPS43_RS04195	COG3383	formate dehydrogenase (NAD+) activity
HPS43_RS04200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPS43_RS04210	COG2223	nitrite transmembrane transporter activity
HPS43_RS04235	COG0583	DNA-binding transcription factor activity
HPS43_RS04240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPS43_RS04255	COG2205	protein histidine kinase activity
HPS43_RS04260	COG0745	RESPONSE REGULATOR receiver
HPS43_RS04275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPS43_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS04310	COG2828	Protein conserved in bacteria
HPS43_RS04315	COG0583	DNA-binding transcription factor activity
HPS43_RS04320	COG0456	acetyltransferase
HPS43_RS04360	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_RS04385	COG4774	siderophore transport
HPS43_RS04405	COG4585	Histidine kinase
HPS43_RS04410	COG0671	phosphoesterase, PA-phosphatase related
HPS43_RS04425	COG1666	GTP binding
HPS43_RS04430	COG1120	ATPase activity
HPS43_RS04435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_RS04440	COG4558	Periplasmic binding protein
HPS43_RS04445	COG3720	iron ion transport
HPS43_RS04455	COG3712	iron ion homeostasis
HPS43_RS04460	COG1595	DNA-templated transcription, initiation
HPS43_RS04475	COG2378	regulation of single-species biofilm formation
HPS43_RS04500	COG0583	DNA-binding transcription factor activity
HPS43_RS04505	COG1113	amino acid transport
HPS43_RS04515	COG1522	sequence-specific DNA binding
HPS43_RS04520	COG1272	protein, Hemolysin III
HPS43_RS04525	COG3191	aminopeptidase activity
HPS43_RS04530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS04535	COG0765	amino acid transport
HPS43_RS04545	COG4942	peptidase
HPS43_RS04565	COG1999	signal sequence binding
HPS43_RS04585	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HPS43_RS04595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS43_RS04600	COG1845	cytochrome c oxidase, subunit III
HPS43_RS04605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPS43_RS04615	COG4772	TonB-dependent receptor
HPS43_RS04635	COG0280	phosphate acetyltransferase
HPS43_RS04635	COG0281	malic enzyme
HPS43_RS04650	COG0697	spore germination
HPS43_RS04685	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS04695	COG0583	DNA-binding transcription factor activity
HPS43_RS04715	COG1396	sequence-specific DNA binding
HPS43_RS04720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS43_RS04745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPS43_RS04760	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPS43_RS04765	COG1285	pathogenesis
HPS43_RS04770	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS04775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS43_RS04790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPS43_RS04805	COG3712	iron ion homeostasis
HPS43_RS04810	COG1595	DNA-templated transcription, initiation
HPS43_RS04820	COG4221	oxidoreductase activity
HPS43_RS04825	COG4773	Receptor
HPS43_RS04845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPS43_RS04850	COG0330	HflC and HflK could
HPS43_RS04875	COG2807	transmembrane transport
HPS43_RS04880	COG2207	Transcriptional regulator
HPS43_RS04885	COG4106	trans-aconitate 2-methyltransferase activity
HPS43_RS04900	COG0583	DNA-binding transcription factor activity
HPS43_RS04940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS43_RS04945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS04950	COG0477	Major facilitator Superfamily
HPS43_RS04955	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPS43_RS04960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS43_RS04965	COG1845	cytochrome c oxidase, subunit III
HPS43_RS04970	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPS43_RS04980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_RS04985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_RS04990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_RS05000	COG2814	Major facilitator Superfamily
HPS43_RS05015	COG0625	glutathione transferase activity
HPS43_RS05075	COG3707	response regulator
HPS43_RS05080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPS43_RS05080	COG2146	nitrite reductase [NAD(P)H] activity
HPS43_RS05085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPS43_RS05085	COG2146	nitrite reductase [NAD(P)H] activity
HPS43_RS05090	COG0243	molybdopterin cofactor binding
HPS43_RS05100	COG0667	Aldo Keto reductase
HPS43_RS05120	COG0583	DNA-binding transcription factor activity
HPS43_RS05125	COG0023	Translation Initiation Factor
HPS43_RS05135	COG0456	acetyltransferase
HPS43_RS05135	COG0454	-acetyltransferase
HPS43_RS05140	COG0583	DNA-binding transcription factor activity
HPS43_RS05145	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_RS05160	COG0840	transmembrane signaling receptor activity
HPS43_RS05165	COG2199	diguanylate cyclase activity
HPS43_RS05165	COG2203	Gaf domain
HPS43_RS05170	COG0640	Transcriptional regulator
HPS43_RS05180	COG0740	serine-type endopeptidase activity
HPS43_RS05185	COG2814	Major facilitator Superfamily
HPS43_RS05215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_RS05225	COG0596	Alpha beta hydrolase
HPS43_RS05235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPS43_RS05245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS43_RS05250	COG0583	DNA-binding transcription factor activity
HPS43_RS05285	COG0028	Belongs to the TPP enzyme family
HPS43_RS05305	COG1230	cation diffusion facilitator family transporter
HPS43_RS05325	COG1132	(ABC) transporter
HPS43_RS05335	COG1201	RNA secondary structure unwinding
HPS43_RS05340	COG1793	dna ligase
HPS43_RS05345	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPS43_RS05345	COG1793	dna ligase
HPS43_RS05380	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS05390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_RS05395	COG0697	spore germination
HPS43_RS05405	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS05415	COG0436	Aminotransferase
HPS43_RS05420	COG0583	DNA-binding transcription factor activity
HPS43_RS05425	COG0583	DNA-binding transcription factor activity
HPS43_RS05455	COG0583	DNA-binding transcription factor activity
HPS43_RS05460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_RS05465	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS05470	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_RS05485	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS05530	COG1595	DNA-templated transcription, initiation
HPS43_RS05560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPS43_RS05565	COG0459	protein refolding
HPS43_RS05575	COG1846	Transcriptional regulator
HPS43_RS05595	COG1917	Cupin 2, conserved barrel domain protein
HPS43_RS05620	COG1137	ATPase activity
HPS43_RS05630	COG0246	Mannitol dehydrogenase
HPS43_RS05635	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPS43_RS05640	COG1252	NADH dehydrogenase
HPS43_RS05645	COG0284	orotidine-5'-phosphate decarboxylase activity
HPS43_RS05650	COG1546	Belongs to the CinA family
HPS43_RS05665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS43_RS05670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPS43_RS05695	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HPS43_RS05700	COG3639	organic phosphonate transmembrane transporter activity
HPS43_RS05705	COG3639	organic phosphonate transmembrane transporter activity
HPS43_RS05725	COG0742	ribosomal rna small subunit methyltransferase
HPS43_RS05730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPS43_RS05735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPS43_RS05740	COG3135	benzoate transporter
HPS43_RS05755	COG2814	Major facilitator Superfamily
HPS43_RS05775	COG4773	Receptor
HPS43_RS05805	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPS43_RS05825	COG0582	viral genome integration into host DNA
HPS43_RS05830	COG0012	GTP binding
HPS43_RS05840	COG0193	aminoacyl-tRNA hydrolase activity
HPS43_RS05860	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPS43_RS05865	COG0840	transmembrane signaling receptor activity
HPS43_RS05880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPS43_RS05905	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPS43_RS05915	COG0204	Acyl-transferase
HPS43_RS05920	COG1368	sulfuric ester hydrolase activity
HPS43_RS05925	COG2186	Transcriptional regulator
HPS43_RS05930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_RS05940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_RS05950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS43_RS05960	COG2205	protein histidine kinase activity
HPS43_RS05965	COG0745	RESPONSE REGULATOR receiver
HPS43_RS05970	COG0277	FAD linked oxidase domain protein
HPS43_RS05985	COG0166	Belongs to the GPI family
HPS43_RS05990	COG0405	Gamma-glutamyltransferase
HPS43_RS05995	COG0438	transferase activity, transferring glycosyl groups
HPS43_RS06000	COG0438	transferase activity, transferring glycosyl groups
HPS43_RS06005	COG0438	transferase activity, transferring glycosyl groups
HPS43_RS06030	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPS43_RS06035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPS43_RS06065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS06085	COG0747	negative chemotaxis
HPS43_RS06090	COG0601	transmembrane transport
HPS43_RS06095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_RS06100	COG4172	Belongs to the ABC transporter superfamily
HPS43_RS06105	COG0154	amidase activity
HPS43_RS06120	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPS43_RS06120	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPS43_RS06125	COG0509	glycine decarboxylation via glycine cleavage system
HPS43_RS06130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPS43_RS06145	COG2081	HI0933 family
HPS43_RS06150	COG1982	Orn Lys Arg decarboxylase major
HPS43_RS06165	COG3706	GGDEF domain
HPS43_RS06175	COG0717	Belongs to the dCTP deaminase family
HPS43_RS06190	COG0489	protein tyrosine kinase activity
HPS43_RS06200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS43_RS06200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS43_RS06220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPS43_RS06220	COG2755	lipolytic protein G-D-S-L family
HPS43_RS06235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPS43_RS06260	COG2200	EAL domain
HPS43_RS06280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_RS06285	COG1129	ABC transporter
HPS43_RS06285	COG0842	Transport permease protein
HPS43_RS06290	COG0842	Transport permease protein
HPS43_RS06300	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS06305	COG0583	DNA-binding transcription factor activity
HPS43_RS06310	COG0697	spore germination
HPS43_RS06320	COG1271	oxidase subunit
HPS43_RS06325	COG1294	oxidase, subunit
HPS43_RS06335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS06370	COG3258	Cytochrome c
HPS43_RS06380	COG0625	glutathione transferase activity
HPS43_RS06385	COG2986	histidine ammonia-lyase
HPS43_RS06390	COG1234	tRNA 3'-trailer cleavage
HPS43_RS06400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPS43_RS06415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPS43_RS06440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPS43_RS06455	COG2828	Protein conserved in bacteria
HPS43_RS06460	COG1595	DNA-templated transcription, initiation
HPS43_RS06465	COG3712	iron ion homeostasis
HPS43_RS06475	COG0165	Argininosuccinate lyase
HPS43_RS06480	COG2205	protein histidine kinase activity
HPS43_RS06490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS43_RS06520	COG0477	Major facilitator Superfamily
HPS43_RS06530	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS06535	COG3246	L-lysine catabolic process to acetate
HPS43_RS06550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPS43_RS06555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS43_RS06560	COG0154	amidase activity
HPS43_RS06565	COG0372	Belongs to the citrate synthase family
HPS43_RS06570	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_RS06605	COG0583	DNA-binding transcription factor activity
HPS43_RS06610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_RS06615	COG0501	Belongs to the peptidase M48B family
HPS43_RS06660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPS43_RS06670	COG0542	response to heat
HPS43_RS06675	COG0071	Belongs to the small heat shock protein (HSP20) family
HPS43_RS06695	COG0583	DNA-binding transcription factor activity
HPS43_RS06710	COG1192	Involved in chromosome partitioning
HPS43_RS06880	COG3621	Patatin-like phospholipase
HPS43_RS06950	COG2003	Belongs to the UPF0758 family
HPS43_RS07010	COG0582	viral genome integration into host DNA
HPS43_RS07025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS43_RS07030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_RS07035	COG0583	DNA-binding transcription factor activity
HPS43_RS07040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPS43_RS07060	COG1652	LysM domain
HPS43_RS07065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPS43_RS07070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPS43_RS07085	COG0625	glutathione transferase activity
HPS43_RS07120	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_RS07155	COG3550	peptidyl-serine autophosphorylation
HPS43_RS07175	COG1414	Transcriptional regulator
HPS43_RS07185	COG0800	Aldolase
HPS43_RS07190	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_RS07195	COG2271	Major facilitator Superfamily
HPS43_RS07200	COG1131	(ABC) transporter
HPS43_RS07215	COG4774	siderophore transport
HPS43_RS07220	COG2814	Major facilitator Superfamily
HPS43_RS07225	COG0326	Molecular chaperone. Has ATPase activity
HPS43_RS07235	COG2233	PERMEase
HPS43_RS07320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS07325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_RS07330	COG3246	L-lysine catabolic process to acetate
HPS43_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS07480	COG0583	DNA-binding transcription factor activity
HPS43_RS07490	COG1695	Transcriptional regulator
HPS43_RS07505	COG0477	Major facilitator Superfamily
HPS43_RS07520	COG0277	FAD linked oxidase domain protein
HPS43_RS07530	COG3842	ATPase activity
HPS43_RS07535	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS43_RS07555	COG0628	permease
HPS43_RS07560	COG0583	DNA-binding transcription factor activity
HPS43_RS07565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_RS07585	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HPS43_RS07595	COG2186	Transcriptional regulator
HPS43_RS07605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS43_RS07630	COG0410	ABC transporter
HPS43_RS07635	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS07640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPS43_RS07650	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS43_RS07655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPS43_RS07660	COG0583	DNA-binding transcription factor activity
HPS43_RS07665	COG0129	dihydroxy-acid dehydratase activity
HPS43_RS07675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS43_RS07680	COG0583	DNA-binding transcription factor activity
HPS43_RS07695	COG2200	EAL domain
HPS43_RS07700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPS43_RS07705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPS43_RS07710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_RS07715	COG2031	fatty acid transporter
HPS43_RS07725	COG1414	Transcriptional regulator
HPS43_RS07735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS43_RS07740	COG4829	muconolactone delta-isomerase
HPS43_RS07750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS43_RS07770	COG0288	reversible hydration of carbon dioxide
HPS43_RS07775	COG1802	Transcriptional regulator
HPS43_RS07780	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS07790	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_RS07810	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS07825	COG0625	glutathione transferase activity
HPS43_RS07840	COG0583	DNA-binding transcription factor activity
HPS43_RS07850	COG0583	DNA-binding transcription factor activity
HPS43_RS07855	COG0477	Major facilitator Superfamily
HPS43_RS07880	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS07900	COG1464	Belongs to the NlpA lipoprotein family
HPS43_RS07915	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPS43_RS07920	COG2890	protein-(glutamine-N5) methyltransferase activity
HPS43_RS07925	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPS43_RS07940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPS43_RS07945	COG1280	lysine exporter protein (LysE YggA)
HPS43_RS07950	COG1522	sequence-specific DNA binding
HPS43_RS07970	COG3622	Belongs to the hyi family
HPS43_RS07990	COG0583	DNA-binding transcription factor activity
HPS43_RS07995	COG2186	Transcriptional regulator
HPS43_RS08000	COG3395	kinase activity
HPS43_RS08005	COG2084	Dehydrogenase
HPS43_RS08010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_RS08015	COG3622	Belongs to the hyi family
HPS43_RS08020	COG0235	Class ii aldolase
HPS43_RS08090	COG0142	geranyltranstransferase activity
HPS43_RS08095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPS43_RS08100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPS43_RS08105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPS43_RS08110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPS43_RS08125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS43_RS08130	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPS43_RS08140	COG2186	Transcriptional regulator
HPS43_RS08145	COG5001	Diguanylate cyclase
HPS43_RS08145	COG5002	protein histidine kinase activity
HPS43_RS08145	COG3447	MASE1 domain protein
HPS43_RS08150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPS43_RS08155	COG0793	Belongs to the peptidase S41A family
HPS43_RS08160	COG4942	peptidase
HPS43_RS08165	COG0588	phosphoglycerate mutase activity
HPS43_RS08175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPS43_RS08180	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPS43_RS08185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPS43_RS08190	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS08200	COG1040	competence protein
HPS43_RS08205	COG2226	methyltransferase
HPS43_RS08210	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HPS43_RS08215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPS43_RS08220	COG0569	domain protein
HPS43_RS08225	COG2204	response regulator
HPS43_RS08230	COG5000	phosphorelay sensor kinase activity
HPS43_RS08240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS43_RS08240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPS43_RS08245	COG1280	lysine exporter protein (LysE YggA)
HPS43_RS08250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPS43_RS08260	COG1733	regulation of RNA biosynthetic process
HPS43_RS08280	COG0546	phosphoglycolate phosphatase activity
HPS43_RS08290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPS43_RS08295	COG0242	peptide deformylase activity
HPS43_RS08300	COG0758	DNA mediated transformation
HPS43_RS08315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS08320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS08325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPS43_RS08330	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS08345	COG1238	metal cluster binding
HPS43_RS08350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS43_RS08355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_RS08375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPS43_RS08380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPS43_RS08385	COG4988	ABC transporter
HPS43_RS08395	COG1294	oxidase, subunit
HPS43_RS08410	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HPS43_RS08420	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPS43_RS08435	COG1137	ATPase activity
HPS43_RS08440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPS43_RS08450	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HPS43_RS08455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS08470	COG1660	Displays ATPase and GTPase activities
HPS43_RS08480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS43_RS08485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPS43_RS08490	COG0792	nuclease activity
HPS43_RS08495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPS43_RS08505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_RS08510	COG1464	Belongs to the NlpA lipoprotein family
HPS43_RS08515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPS43_RS08525	COG1309	transcriptional regulator
HPS43_RS08530	COG0471	metal ion transport
HPS43_RS08535	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS43_RS08540	COG0772	Belongs to the SEDS family
HPS43_RS08545	COG0768	penicillin binding
HPS43_RS08555	COG1792	Involved in formation and maintenance of cell shape
HPS43_RS08560	COG1077	Cell shape determining protein MreB Mrl
HPS43_RS08565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPS43_RS08570	COG0154	amidase activity
HPS43_RS08575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPS43_RS08590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPS43_RS08595	COG0708	Exodeoxyribonuclease III
HPS43_RS08600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPS43_RS08610	COG0583	DNA-binding transcription factor activity
HPS43_RS08620	COG0583	DNA-binding transcription factor activity
HPS43_RS08645	COG1764	response to oxidative stress
HPS43_RS08650	COG1846	Transcriptional regulator
HPS43_RS08710	COG0640	Transcriptional regulator
HPS43_RS08740	COG3189	MarR family transcriptional regulator
HPS43_RS08760	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS08765	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPS43_RS08765	COG0351	phosphomethylpyrimidine kinase
HPS43_RS08765	COG0352	thiamine-phosphate diphosphorylase activity
HPS43_RS08825	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPS43_RS08830	COG0513	Belongs to the DEAD box helicase family
HPS43_RS08840	COG0617	tRNA 3'-terminal CCA addition
HPS43_RS08850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPS43_RS08855	COG2308	Evidence 4 Homologs of previously reported genes of
HPS43_RS08865	COG1305	Transglutaminase-like
HPS43_RS08885	COG1950	PFAM Membrane protein of
HPS43_RS08890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HPS43_RS08895	COG0438	transferase activity, transferring glycosyl groups
HPS43_RS08910	COG0066	3-isopropylmalate dehydratase activity
HPS43_RS08925	COG0583	DNA-binding transcription factor activity
HPS43_RS08935	COG0477	Major facilitator Superfamily
HPS43_RS08940	COG0154	amidase activity
HPS43_RS08945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPS43_RS08960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPS43_RS08970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPS43_RS08975	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HPS43_RS08985	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPS43_RS09000	COG0735	belongs to the Fur family
HPS43_RS09005	COG0523	cobalamin synthesis protein
HPS43_RS09015	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPS43_RS09020	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPS43_RS09030	COG2096	Adenosyltransferase
HPS43_RS09040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPS43_RS09050	COG0463	Glycosyl transferase, family 2
HPS43_RS09065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS43_RS09080	COG4106	trans-aconitate 2-methyltransferase activity
HPS43_RS09085	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPS43_RS09100	COG0321	lipoyl(octanoyl) transferase activity
HPS43_RS09105	COG2921	Belongs to the UPF0250 family
HPS43_RS09115	COG1686	Belongs to the peptidase S11 family
HPS43_RS09140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPS43_RS09150	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HPS43_RS09170	COG0859	PFAM glycosyl transferase family 9
HPS43_RS09180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPS43_RS09200	COG0110	maltose O-acetyltransferase activity
HPS43_RS09220	COG2089	acid synthase
HPS43_RS09235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPS43_RS09260	COG1086	Polysaccharide biosynthesis protein
HPS43_RS09265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_RS09280	COG0477	Major facilitator Superfamily
HPS43_RS09300	COG3568	Endonuclease Exonuclease Phosphatase
HPS43_RS09305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPS43_RS09330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS43_RS09345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_RS09350	COG1956	GAF domain-containing protein
HPS43_RS09355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS09380	COG2186	Transcriptional regulator
HPS43_RS09415	COG4106	trans-aconitate 2-methyltransferase activity
HPS43_RS09425	COG2814	Major facilitator Superfamily
HPS43_RS09435	COG0625	glutathione transferase activity
HPS43_RS09440	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPS43_RS09445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPS43_RS09450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPS43_RS09460	COG1965	Belongs to the frataxin family
HPS43_RS09470	COG0019	diaminopimelate decarboxylase activity
HPS43_RS09475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPS43_RS09480	COG1333	cytochrome c biogenesis protein
HPS43_RS09490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HPS43_RS09505	COG4232	protein-disulfide reductase activity
HPS43_RS09510	COG1324	tolerance protein
HPS43_RS09520	COG0203	ribosomal protein L17
HPS43_RS09525	COG0202	RNA polymerase activity
HPS43_RS09530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPS43_RS09535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPS43_RS09540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPS43_RS09545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPS43_RS09550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPS43_RS09555	COG0201	protein transport
HPS43_RS09560	COG0200	Binds to the 23S rRNA
HPS43_RS09565	COG1841	ribosomal large subunit assembly
HPS43_RS09570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPS43_RS09575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPS43_RS09580	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPS43_RS09585	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPS43_RS09590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPS43_RS09595	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPS43_RS09600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPS43_RS09605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPS43_RS09620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS43_RS09620	COG2169	Transcriptional regulator
HPS43_RS09655	COG4177	L-phenylalanine transmembrane transporter activity
HPS43_RS09670	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPS43_RS09675	COG0255	Belongs to the universal ribosomal protein uL29 family
HPS43_RS09680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPS43_RS09685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPS43_RS09690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPS43_RS09695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPS43_RS09700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPS43_RS09705	COG0089	rRNA binding
HPS43_RS09715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPS43_RS09720	COG0051	transcription antitermination factor activity, RNA binding
HPS43_RS09725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPS43_RS09730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPS43_RS09735	COG0049	tRNA binding
HPS43_RS09740	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HPS43_RS09745	COG0745	RESPONSE REGULATOR receiver
HPS43_RS09760	COG5002	protein histidine kinase activity
HPS43_RS09775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPS43_RS09780	COG0085	RNA polymerase activity
HPS43_RS09785	COG0222	ribosome binding
HPS43_RS09790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPS43_RS09795	COG0081	regulation of translation
HPS43_RS09800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPS43_RS09810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPS43_RS09820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPS43_RS09860	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS43_RS09865	COG3842	ATPase activity
HPS43_RS09875	COG1349	DNA-binding transcription factor activity
HPS43_RS09900	COG0583	DNA-binding transcription factor activity
HPS43_RS09905	COG0252	asparaginase activity
HPS43_RS09910	COG1475	DNA binding
HPS43_RS09920	COG1192	Involved in chromosome partitioning
HPS43_RS09925	COG0357	Ribosomal RNA small subunit methyltransferase G
HPS43_RS09930	COG0445	tRNA wobble uridine modification
HPS43_RS09935	COG1278	Cold shock
HPS43_RS09940	COG3180	Ammonia monooxygenase
HPS43_RS09945	COG0436	Aminotransferase
HPS43_RS09975	COG0038	chloride channel
HPS43_RS09985	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPS43_RS09995	COG0601	transmembrane transport
HPS43_RS10000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_RS10005	COG0444	Belongs to the ABC transporter superfamily
HPS43_RS10010	COG4608	Belongs to the ABC transporter superfamily
HPS43_RS10015	COG1473	amidohydrolase
HPS43_RS10025	COG2175	clavaminate synthase activity
HPS43_RS10035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPS43_RS10040	COG0753	catalase activity
HPS43_RS10050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HPS43_RS10055	COG0594	ribonuclease P activity
HPS43_RS10060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPS43_RS10065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPS43_RS10070	COG0592	DNA-directed DNA polymerase activity
HPS43_RS10080	COG0583	DNA-binding transcription factor activity
HPS43_RS10105	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPS43_RS10120	COG0583	DNA-binding transcription factor activity
HPS43_RS10125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS10130	COG0765	amino acid transport
HPS43_RS10135	COG0765	amino acid transport
HPS43_RS10140	COG1126	abc transporter atp-binding protein
HPS43_RS10180	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS43_RS10185	COG1177	transmembrane transport
HPS43_RS10240	COG1609	Transcriptional regulator
HPS43_RS10250	COG3842	ATPase activity
HPS43_RS10255	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS43_RS10260	COG1177	transmembrane transport
HPS43_RS10285	COG0251	oxidation-reduction process
HPS43_RS10290	COG0402	S-adenosylhomocysteine deaminase activity
HPS43_RS10310	COG1744	ABC transporter substrate-binding protein PnrA-like
HPS43_RS10320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPS43_RS10335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPS43_RS10350	COG2814	Major facilitator Superfamily
HPS43_RS10365	COG3781	membrane
HPS43_RS10370	COG1522	sequence-specific DNA binding
HPS43_RS10375	COG0028	Belongs to the TPP enzyme family
HPS43_RS10380	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS10385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_RS10410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS43_RS10415	COG2922	Belongs to the Smg family
HPS43_RS10425	COG2358	TRAP transporter, solute receptor (TAXI family
HPS43_RS10445	COG0765	amino acid transport
HPS43_RS10450	COG0765	amino acid transport
HPS43_RS10455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS10460	COG3422	double-strand break repair
HPS43_RS10465	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS10470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPS43_RS10530	COG4977	sequence-specific DNA binding
HPS43_RS10535	COG2814	Major facilitator Superfamily
HPS43_RS10545	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPS43_RS10555	COG3339	Conserved Protein
HPS43_RS10585	COG2186	Transcriptional regulator
HPS43_RS10590	COG2814	Major facilitator Superfamily
HPS43_RS10600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPS43_RS10645	COG1595	DNA-templated transcription, initiation
HPS43_RS10650	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS10665	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS10675	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS10710	COG2207	Transcriptional regulator
HPS43_RS10730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPS43_RS10735	COG0183	Belongs to the thiolase family
HPS43_RS10740	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HPS43_RS10745	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS10750	COG1473	amidohydrolase
HPS43_RS10760	COG1742	UPF0060 membrane protein
HPS43_RS10765	COG0789	Transcriptional regulator
HPS43_RS10775	COG1280	lysine exporter protein (LysE YggA)
HPS43_RS10800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS43_RS10810	COG0018	arginyl-trna synthetase
HPS43_RS10825	COG0395	ABC-type sugar transport system, permease component
HPS43_RS10830	COG1175	transmembrane transport
HPS43_RS10835	COG1653	transport
HPS43_RS10840	COG3842	ATPase activity
HPS43_RS10845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS43_RS10850	COG1609	Transcriptional regulator
HPS43_RS10860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS43_RS10875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPS43_RS10885	COG0583	DNA-binding transcription factor activity
HPS43_RS10905	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HPS43_RS10910	COG1280	lysine exporter protein (LysE YggA)
HPS43_RS10915	COG0513	Belongs to the DEAD box helicase family
HPS43_RS10920	COG5339	Protein conserved in bacteria
HPS43_RS10925	COG5339	Protein conserved in bacteria
HPS43_RS10930	COG1228	amidohydrolase
HPS43_RS10940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_RS10945	COG0601	transmembrane transport
HPS43_RS10950	COG0747	negative chemotaxis
HPS43_RS10955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPS43_RS10965	COG2207	Transcriptional regulator
HPS43_RS10965	COG3708	Transcriptional regulator
HPS43_RS10985	COG0583	DNA-binding transcription factor activity
HPS43_RS11020	COG2969	positive regulation of protein catabolic process
HPS43_RS11025	COG0625	glutathione transferase activity
HPS43_RS11030	COG2857	Cytochrome c1
HPS43_RS11035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPS43_RS11040	COG0723	plastoquinol--plastocyanin reductase activity
HPS43_RS11045	COG1970	mechanosensitive ion channel activity
HPS43_RS11050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPS43_RS11055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_RS11070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPS43_RS11075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPS43_RS11080	COG0537	adenosine 5'-monophosphoramidase activity
HPS43_RS11085	COG0140	phosphoribosyl-ATP diphosphatase activity
HPS43_RS11095	COG0107	imidazoleglycerol-phosphate synthase activity
HPS43_RS11100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPS43_RS11105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPS43_RS11110	COG0131	Imidazoleglycerol-phosphate dehydratase
HPS43_RS11115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS43_RS11120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPS43_RS11125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPS43_RS11130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPS43_RS11140	COG0842	Transport permease protein
HPS43_RS11145	COG1131	(ABC) transporter
HPS43_RS11155	COG2853	Lipoprotein
HPS43_RS11160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPS43_RS11165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPS43_RS11170	COG1127	ABC transporter
HPS43_RS11175	COG2070	2-Nitropropane dioxygenase
HPS43_RS11185	COG0477	Major facilitator Superfamily
HPS43_RS11200	COG0583	DNA-binding transcription factor activity
HPS43_RS11205	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPS43_RS11210	COG0511	ligase activity, forming carbon-carbon bonds
HPS43_RS11225	COG1984	allophanate hydrolase subunit 2
HPS43_RS11240	COG0069	glutamate synthase activity
HPS43_RS11240	COG0070	glutamate synthase
HPS43_RS11240	COG0067	glutamate synthase
HPS43_RS11265	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS43_RS11285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS43_RS11315	COG1612	heme a metabolic process
HPS43_RS11325	COG1999	signal sequence binding
HPS43_RS11345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPS43_RS11350	COG2814	Major facilitator Superfamily
HPS43_RS11360	COG0438	transferase activity, transferring glycosyl groups
HPS43_RS11405	COG1074	ATP-dependent DNA helicase activity
HPS43_RS11420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPS43_RS11440	COG4774	siderophore transport
HPS43_RS11445	COG4592	Periplasmic binding protein
HPS43_RS11450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_RS11455	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_RS11460	COG1120	ATPase activity
HPS43_RS11465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_RS11480	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPS43_RS11505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPS43_RS11510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPS43_RS11515	COG2814	Major facilitator Superfamily
HPS43_RS11520	COG0583	DNA-binding transcription factor activity
HPS43_RS11530	COG2423	ornithine cyclodeaminase activity
HPS43_RS11535	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HPS43_RS11540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPS43_RS11550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPS43_RS11560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPS43_RS11565	COG0463	Glycosyl transferase, family 2
HPS43_RS11615	COG0737	Belongs to the 5'-nucleotidase family
HPS43_RS11630	COG2188	Transcriptional regulator
HPS43_RS11640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPS43_RS11645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPS43_RS11660	COG0840	transmembrane signaling receptor activity
HPS43_RS11665	COG2814	Major facilitator Superfamily
HPS43_RS11680	COG3188	usher protein
HPS43_RS11740	COG1802	Transcriptional regulator
HPS43_RS11750	COG3069	C4-dicarboxylate transmembrane transporter activity
HPS43_RS11755	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_RS11780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_RS11790	COG0747	negative chemotaxis
HPS43_RS11815	COG1464	Belongs to the NlpA lipoprotein family
HPS43_RS11820	COG0431	NADPH-dependent FMN reductase
HPS43_RS11825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS43_RS11830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_RS11835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_RS11850	COG2011	ABC-type metal ion transport system permease component
HPS43_RS11855	COG1464	Belongs to the NlpA lipoprotein family
HPS43_RS11860	COG1116	anion transmembrane transporter activity
HPS43_RS11865	COG3585	molybdate ion transport
HPS43_RS11870	COG3064	Membrane
HPS43_RS11895	COG1607	acyl-coa hydrolase
HPS43_RS11910	COG0437	4 iron, 4 sulfur cluster binding
HPS43_RS11915	COG2864	formate dehydrogenase
HPS43_RS11930	COG3276	selenocysteine insertion sequence binding
HPS43_RS11940	COG1215	transferase activity, transferring glycosyl groups
HPS43_RS11945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_RS11950	COG1305	Transglutaminase-like
HPS43_RS11955	COG0709	Synthesizes selenophosphate from selenide and ATP
HPS43_RS11990	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_RS11995	COG3284	Transcriptional regulator
HPS43_RS12000	COG0134	indole-3-glycerol-phosphate synthase activity
HPS43_RS12005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPS43_RS12010	COG0512	Glutamine amidotransferase of anthranilate synthase
HPS43_RS12020	COG0546	phosphoglycolate phosphatase activity
HPS43_RS12025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPS43_RS12030	COG2967	ApaG domain
HPS43_RS12040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS43_RS12045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS43_RS12055	COG0037	tRNA processing
HPS43_RS12070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS43_RS12085	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_RS12090	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_RS12105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS43_RS12130	COG3473	Maleate cis-trans isomerase
HPS43_RS12135	COG0583	DNA-binding transcription factor activity
HPS43_RS12150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS43_RS12160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_RS12165	COG1024	Enoyl-CoA hydratase
HPS43_RS12180	COG0356	it plays a direct role in the translocation of protons across the membrane
HPS43_RS12195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPS43_RS12200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPS43_RS12205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPS43_RS12215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPS43_RS12225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPS43_RS12230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPS43_RS12235	COG0210	DNA helicase
HPS43_RS12250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPS43_RS12265	COG2171	N-acyltransferase activity
HPS43_RS12275	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPS43_RS12285	COG4608	Belongs to the ABC transporter superfamily
HPS43_RS12290	COG0444	Belongs to the ABC transporter superfamily
HPS43_RS12300	COG0601	transmembrane transport
HPS43_RS12305	COG0747	negative chemotaxis
HPS43_RS12310	COG2988	succinylglutamate desuccinylase activity
HPS43_RS12320	COG0583	DNA-binding transcription factor activity
HPS43_RS12325	COG0747	negative chemotaxis
HPS43_RS12335	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPS43_RS12340	COG1024	Enoyl-CoA hydratase
HPS43_RS12345	COG1024	Enoyl-CoA hydratase
HPS43_RS12355	COG1309	transcriptional regulator
HPS43_RS12370	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_RS12385	COG2814	Major facilitator Superfamily
HPS43_RS12400	COG1764	response to oxidative stress
HPS43_RS12405	COG0583	DNA-binding transcription factor activity
HPS43_RS12415	COG1595	DNA-templated transcription, initiation
HPS43_RS12420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPS43_RS12425	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_RS12440	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS43_RS12460	COG1129	ABC transporter
HPS43_RS12475	COG1802	Transcriptional regulator
HPS43_RS12485	COG0583	DNA-binding transcription factor activity
HPS43_RS12495	COG2988	succinylglutamate desuccinylase activity
HPS43_RS12505	COG2918	glutathione biosynthetic process
HPS43_RS12535	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS43_RS12540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS43_RS12550	COG2721	sulfolactate sulfo-lyase activity
HPS43_RS12555	COG2721	sulfolactate sulfo-lyase activity
HPS43_RS12560	COG2188	Transcriptional regulator
HPS43_RS12565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS43_RS12570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS43_RS12570	COG2813	Specifically methylates the guanine in position
HPS43_RS12575	COG2223	nitrite transmembrane transporter activity
HPS43_RS12585	COG2860	membrane
HPS43_RS12590	COG1802	Transcriptional regulator
HPS43_RS12600	COG1984	allophanate hydrolase subunit 2
HPS43_RS12605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPS43_RS12615	COG0583	DNA-binding transcription factor activity
HPS43_RS12625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS43_RS12640	COG2132	Multicopper oxidase
HPS43_RS12665	COG0745	RESPONSE REGULATOR receiver
HPS43_RS12670	COG2226	methyltransferase
HPS43_RS12685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPS43_RS12695	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPS43_RS12705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPS43_RS12710	COG0351	phosphomethylpyrimidine kinase
HPS43_RS12715	COG2022	thiamine diphosphate biosynthetic process
HPS43_RS12720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPS43_RS12725	COG4771	TonB-dependent receptor
HPS43_RS12735	COG2186	Transcriptional regulator
HPS43_RS12750	COG1063	alcohol dehydrogenase
HPS43_RS12760	COG0765	amino acid transport
HPS43_RS12765	COG1126	abc transporter atp-binding protein
HPS43_RS12770	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_RS12775	COG0246	Mannitol dehydrogenase
HPS43_RS12790	COG1194	a g-specific adenine glycosylase
HPS43_RS12815	COG2177	Part of the ABC transporter FtsEX involved in
HPS43_RS12820	COG2884	Cell division ATP-binding protein ftsE
HPS43_RS12825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS12830	COG4597	amino acid ABC transporter
HPS43_RS12835	COG0765	amino acid transport
HPS43_RS12840	COG1126	abc transporter atp-binding protein
HPS43_RS12865	COG1129	ABC transporter
HPS43_RS12870	COG4177	L-phenylalanine transmembrane transporter activity
HPS43_RS12885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS43_RS12890	COG2081	HI0933 family
HPS43_RS12900	COG0077	Prephenate dehydratase
HPS43_RS12900	COG1605	Chorismate mutase
HPS43_RS12935	COG0477	Major facilitator Superfamily
HPS43_RS12945	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HPS43_RS12950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPS43_RS12970	COG0237	dephospho-CoA kinase activity
HPS43_RS12975	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPS43_RS13005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_RS13010	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS43_RS13025	COG3833	ABC-type maltose transport systems, permease component
HPS43_RS13030	COG1175	transmembrane transport
HPS43_RS13035	COG3842	ATPase activity
HPS43_RS13055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPS43_RS13090	COG0410	ABC transporter
HPS43_RS13110	COG3706	GGDEF domain
HPS43_RS13125	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS13130	COG1024	Enoyl-CoA hydratase
HPS43_RS13170	COG4638	Rieske (2fe-2S)
HPS43_RS13175	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS43_RS13180	COG1335	isochorismatase
HPS43_RS13185	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS13195	COG0741	lytic transglycosylase activity
HPS43_RS13200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPS43_RS13205	COG0352	thiamine-phosphate diphosphorylase activity
HPS43_RS13220	COG1678	Uncharacterized ACR, COG1678
HPS43_RS13225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPS43_RS13255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS43_RS13260	COG0436	Aminotransferase
HPS43_RS13265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS13280	COG1126	abc transporter atp-binding protein
HPS43_RS13285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS43_RS13295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPS43_RS13300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS43_RS13310	COG3842	ATPase activity
HPS43_RS13315	COG1175	transmembrane transport
HPS43_RS13325	COG0642	Histidine kinase
HPS43_RS13335	COG0557	exoribonuclease II activity
HPS43_RS13340	COG3150	esterase
HPS43_RS13345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPS43_RS13350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_RS13355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPS43_RS13360	COG0511	ligase activity, forming carbon-carbon bonds
HPS43_RS13365	COG0439	Biotin carboxylase
HPS43_RS13370	COG2264	protein methyltransferase activity
HPS43_RS13380	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPS43_RS13380	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPS43_RS13405	COG1696	Membrane protein involved in D-alanine export
HPS43_RS13410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPS43_RS13440	COG1522	sequence-specific DNA binding
HPS43_RS13445	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS13455	COG0583	DNA-binding transcription factor activity
HPS43_RS13470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS43_RS13475	COG1042	CoA-binding domain protein
HPS43_RS13475	COG0045	succinate-CoA ligase (ADP-forming) activity
HPS43_RS13475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPS43_RS13480	COG1335	isochorismatase
HPS43_RS13485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_RS13490	COG1116	anion transmembrane transporter activity
HPS43_RS13505	COG3028	Belongs to the UPF0307 family
HPS43_RS13510	COG0312	modulator of DNA gyrase
HPS43_RS13515	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS43_RS13525	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_RS13530	COG4177	L-phenylalanine transmembrane transporter activity
HPS43_RS13545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPS43_RS13550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPS43_RS13555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPS43_RS13565	COG0316	Belongs to the HesB IscA family
HPS43_RS13580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPS43_RS13590	COG1280	lysine exporter protein (LysE YggA)
HPS43_RS13595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPS43_RS13600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPS43_RS13615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPS43_RS13615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPS43_RS13630	COG2766	serine protein kinase
HPS43_RS13635	COG2718	Belongs to the UPF0229 family
HPS43_RS13640	COG2719	SpoVR family
HPS43_RS13650	COG0583	DNA-binding transcription factor activity
HPS43_RS13655	COG1942	4-Oxalocrotonate Tautomerase
HPS43_RS13665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS43_RS13675	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS13720	COG4789	Type iii secretion
HPS43_RS13790	COG4669	(LipO)protein
HPS43_RS13820	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPS43_RS13825	COG4790	Type iii secretion
HPS43_RS13830	COG4794	Type iii secretion
HPS43_RS13835	COG4791	protein targeting
HPS43_RS13870	COG2208	phosphoserine phosphatase activity
HPS43_RS13870	COG2770	Histidine kinase
HPS43_RS13880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPS43_RS13885	COG2172	sigma factor antagonist activity
HPS43_RS13890	COG1366	Belongs to the anti-sigma-factor antagonist family
HPS43_RS13930	COG0741	lytic transglycosylase activity
HPS43_RS13930	COG1388	LysM domain
HPS43_RS13935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPS43_RS13940	COG2226	methyltransferase
HPS43_RS13945	COG0328	RNA-DNA hybrid ribonuclease activity
HPS43_RS13955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_RS13960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPS43_RS13975	COG1671	Belongs to the UPF0178 family
HPS43_RS13990	COG0786	glutamate:sodium symporter activity
HPS43_RS14000	COG0463	Glycosyl transferase, family 2
HPS43_RS14005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPS43_RS14020	COG0583	DNA-binding transcription factor activity
HPS43_RS14040	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_RS14060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_RS14070	COG0583	DNA-binding transcription factor activity
HPS43_RS14080	COG1346	cytolysis
HPS43_RS14090	COG0697	spore germination
HPS43_RS14095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS14110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPS43_RS14120	COG1522	sequence-specific DNA binding
HPS43_RS14135	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPS43_RS14140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_RS14155	COG0823	Involved in the tonB-independent uptake of proteins
HPS43_RS14165	COG0848	biopolymer transport protein
HPS43_RS14170	COG0811	peptide transport
HPS43_RS14175	COG0824	Thioesterase
HPS43_RS14180	COG0442	prolyl-tRNA aminoacylation
HPS43_RS14210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS43_RS14225	COG2084	Dehydrogenase
HPS43_RS14230	COG0405	Gamma-glutamyltransferase
HPS43_RS14270	COG0129	dihydroxy-acid dehydratase activity
HPS43_RS14275	COG4654	Cytochrome c, class I
HPS43_RS14280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS43_RS14290	COG1522	sequence-specific DNA binding
HPS43_RS14330	COG0583	DNA-binding transcription factor activity
HPS43_RS14340	COG1473	amidohydrolase
HPS43_RS14345	COG0418	dihydroorotase activity
HPS43_RS14360	COG2001	Belongs to the MraZ family
HPS43_RS14365	COG0275	rRNA processing
HPS43_RS14370	COG3116	cell division
HPS43_RS14380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS43_RS14385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPS43_RS14390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPS43_RS14400	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPS43_RS14405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPS43_RS14410	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPS43_RS14415	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPS43_RS14425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPS43_RS14430	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPS43_RS14440	COG0739	heme binding
HPS43_RS14445	COG0653	protein targeting
HPS43_RS14460	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS14465	COG0028	Belongs to the TPP enzyme family
HPS43_RS14475	COG0300	oxidoreductase activity
HPS43_RS14480	COG1522	sequence-specific DNA binding
HPS43_RS14495	COG2239	Acts as a magnesium transporter
HPS43_RS14505	COG2855	membrane
HPS43_RS14510	COG0583	DNA-binding transcription factor activity
HPS43_RS14515	COG1473	amidohydrolase
HPS43_RS14520	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS14525	COG0483	inositol monophosphate 1-phosphatase activity
HPS43_RS14530	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPS43_RS14530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_RS14535	COG1501	Belongs to the glycosyl hydrolase 31 family
HPS43_RS14540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPS43_RS14545	COG2011	ABC-type metal ion transport system permease component
HPS43_RS14560	COG1595	DNA-templated transcription, initiation
HPS43_RS14565	COG3712	iron ion homeostasis
HPS43_RS14585	COG0840	transmembrane signaling receptor activity
HPS43_RS14590	COG0583	DNA-binding transcription factor activity
HPS43_RS14600	COG0735	belongs to the Fur family
HPS43_RS14625	COG2818	Glycosylase
HPS43_RS14630	COG1368	sulfuric ester hydrolase activity
HPS43_RS14635	COG2982	Protein involved in outer membrane biogenesis
HPS43_RS14650	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS14665	COG2124	cytochrome p450
HPS43_RS14715	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPS43_RS14730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS43_RS14745	COG3178	'Phosphotransferase
HPS43_RS14755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_RS14760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPS43_RS14765	COG1929	Belongs to the glycerate kinase type-1 family
HPS43_RS14770	COG0469	pyruvate kinase activity
HPS43_RS14775	COG0700	Nucleoside recognition
HPS43_RS14780	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS14785	COG0242	peptide deformylase activity
HPS43_RS14805	COG0204	Acyl-transferase
HPS43_RS14810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPS43_RS14815	COG0751	glycine-tRNA ligase activity
HPS43_RS14820	COG0752	glycyl-tRNA synthetase alpha subunit
HPS43_RS14825	COG1024	Enoyl-CoA hydratase
HPS43_RS14845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_RS14850	COG2030	dehydratase
HPS43_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS14870	COG2070	2-Nitropropane dioxygenase
HPS43_RS14880	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS14885	COG0183	Belongs to the thiolase family
HPS43_RS14895	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS14905	COG1024	Enoyl-CoA hydratase
HPS43_RS14915	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HPS43_RS14925	COG2301	Belongs to the HpcH HpaI aldolase family
HPS43_RS14930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPS43_RS14940	COG0617	tRNA 3'-terminal CCA addition
HPS43_RS14955	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPS43_RS14965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPS43_RS14970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPS43_RS14975	COG0586	Pfam SNARE associated Golgi protein
HPS43_RS14985	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPS43_RS14990	COG0802	atpase or kinase
HPS43_RS15005	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS15025	COG0531	amino acid
HPS43_RS15030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_RS15035	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS15040	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS15045	COG0583	DNA-binding transcription factor activity
HPS43_RS15050	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS43_RS15070	COG2175	clavaminate synthase activity
HPS43_RS15085	COG0583	DNA-binding transcription factor activity
HPS43_RS15095	COG0579	oxidoreductase
HPS43_RS15105	COG0259	pyridoxamine-phosphate oxidase activity
HPS43_RS15120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_RS15125	COG1136	(ABC) transporter
HPS43_RS15125	COG0577	efflux transmembrane transporter activity
HPS43_RS15130	COG1538	Outer membrane efflux protein
HPS43_RS15135	COG0583	DNA-binding transcription factor activity
HPS43_RS15155	COG0577	efflux transmembrane transporter activity
HPS43_RS15155	COG1136	(ABC) transporter
HPS43_RS15185	COG1136	(ABC) transporter
HPS43_RS15190	COG0577	efflux transmembrane transporter activity
HPS43_RS15190	COG1136	(ABC) transporter
HPS43_RS15200	COG1566	PFAM secretion protein HlyD family protein
HPS43_RS15205	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPS43_RS15240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPS43_RS15250	COG0800	Aldolase
HPS43_RS15265	COG0463	Glycosyl transferase, family 2
HPS43_RS15265	COG1216	Glycosyl transferase, family 2
HPS43_RS15290	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS15295	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HPS43_RS15315	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS43_RS15320	COG4638	Rieske (2fe-2S)
HPS43_RS15345	COG0747	negative chemotaxis
HPS43_RS15355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_RS15360	COG0444	Belongs to the ABC transporter superfamily
HPS43_RS15365	COG4608	Belongs to the ABC transporter superfamily
HPS43_RS15385	COG2746	aminoglycoside 3-N-acetyltransferase activity
HPS43_RS15390	COG0488	(ABC) transporter
HPS43_RS15415	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPS43_RS15420	COG2894	cell division
HPS43_RS15425	COG0850	regulation of cytokinetic process
HPS43_RS15430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS43_RS15440	COG1294	oxidase, subunit
HPS43_RS15445	COG0514	ATP-dependent DNA helicase (RecQ)
HPS43_RS15455	COG0745	RESPONSE REGULATOR receiver
HPS43_RS15460	COG4191	Histidine kinase
HPS43_RS15465	COG2255	four-way junction helicase activity
HPS43_RS15475	COG1090	epimerase
HPS43_RS15480	COG0632	four-way junction helicase activity
HPS43_RS15505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS43_RS15515	COG0006	proline dipeptidase activity
HPS43_RS15530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPS43_RS15535	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_RS15550	COG4783	chaperone-mediated protein folding
HPS43_RS15590	COG2814	Major facilitator Superfamily
HPS43_RS15595	COG4771	TonB-dependent receptor
HPS43_RS15605	COG0513	Belongs to the DEAD box helicase family
HPS43_RS15620	COG1546	Belongs to the CinA family
HPS43_RS15620	COG1058	Belongs to the CinA family
HPS43_RS15625	COG1414	Transcriptional regulator
HPS43_RS15640	COG0167	dihydroorotate dehydrogenase activity
HPS43_RS15645	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPS43_RS15650	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPS43_RS15770	COG0629	single-stranded DNA binding
HPS43_RS15775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPS43_RS15790	COG0789	Transcriptional regulator
HPS43_RS15800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPS43_RS15885	COG0431	NADPH-dependent FMN reductase
HPS43_RS15890	COG1393	Belongs to the ArsC family
HPS43_RS15895	COG0798	PFAM Bile acid sodium symporter
HPS43_RS15905	COG0640	Transcriptional regulator
HPS43_RS15975	COG1569	PIN domain
HPS43_RS15980	COG3311	Transcriptional regulator
HPS43_RS16035	COG2003	Belongs to the UPF0758 family
HPS43_RS16100	COG0789	Transcriptional regulator
HPS43_RS16135	COG2326	polyphosphate kinase activity
HPS43_RS16140	COG2217	Heavy metal translocating P-type atpase
HPS43_RS16155	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HPS43_RS16165	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPS43_RS16170	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HPS43_RS16190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS43_RS16210	COG0300	oxidoreductase activity
HPS43_RS16215	COG1309	transcriptional regulator
HPS43_RS16220	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HPS43_RS16225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS43_RS16230	COG0789	Transcriptional regulator
HPS43_RS16235	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPS43_RS16255	COG5002	protein histidine kinase activity
HPS43_RS16260	COG0745	RESPONSE REGULATOR receiver
HPS43_RS16265	COG2132	Multicopper oxidase
HPS43_RS16305	COG0583	DNA-binding transcription factor activity
HPS43_RS16310	COG1396	sequence-specific DNA binding
HPS43_RS16335	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_RS16350	COG0582	viral genome integration into host DNA
HPS43_RS16370	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS43_RS16375	COG0735	belongs to the Fur family
HPS43_RS16380	COG0497	DNA recombination
HPS43_RS16390	COG1420	regulation of RNA biosynthetic process
HPS43_RS16395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPS43_RS16405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPS43_RS16415	COG0443	Heat shock 70 kDa protein
HPS43_RS16420	COG0484	heat shock protein binding
HPS43_RS16430	COG0612	Peptidase, M16
HPS43_RS16455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPS43_RS16490	COG0840	transmembrane signaling receptor activity
HPS43_RS16495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_RS16510	COG0745	RESPONSE REGULATOR receiver
HPS43_RS16515	COG2205	protein histidine kinase activity
HPS43_RS16520	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HPS43_RS16525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HPS43_RS16530	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HPS43_RS16545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPS43_RS16555	COG1193	negative regulation of DNA recombination
HPS43_RS16560	COG0492	ferredoxin-NADP+ reductase activity
HPS43_RS16565	COG1674	ftsk spoiiie
HPS43_RS16570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPS43_RS16575	COG0251	oxidation-reduction process
HPS43_RS16580	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS43_RS16585	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPS43_RS16585	COG0517	IMP dehydrogenase activity
HPS43_RS16605	COG0601	transmembrane transport
HPS43_RS16620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS43_RS16625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPS43_RS16630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPS43_RS16675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_RS16685	COG4774	siderophore transport
HPS43_RS16690	COG4607	ABC-type enterochelin transport system periplasmic component
HPS43_RS16695	COG4604	ABC transporter, ATP-binding protein
HPS43_RS16700	COG4605	iron ion homeostasis
HPS43_RS16705	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_RS16735	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS16740	COG3022	response to hydroperoxide
HPS43_RS16745	COG1289	transmembrane transporter activity
HPS43_RS16750	COG0028	Belongs to the TPP enzyme family
HPS43_RS16755	COG0440	acetolactate synthase activity
HPS43_RS16760	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPS43_RS16765	COG1183	phosphatidylcholine synthase activity
HPS43_RS16775	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPS43_RS16780	COG1185	polyribonucleotide nucleotidyltransferase activity
HPS43_RS16795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS43_RS16805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS43_RS16815	COG2207	Transcriptional regulator
HPS43_RS16840	COG0149	triose-phosphate isomerase activity
HPS43_RS16845	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPS43_RS16865	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HPS43_RS16870	COG1959	2 iron, 2 sulfur cluster binding
HPS43_RS16875	COG2814	Major facilitator Superfamily
HPS43_RS16890	COG0840	transmembrane signaling receptor activity
HPS43_RS16910	COG1910	domain protein
HPS43_RS16945	COG1116	anion transmembrane transporter activity
HPS43_RS16975	COG1595	DNA-templated transcription, initiation
HPS43_RS16990	COG1595	DNA-templated transcription, initiation
HPS43_RS16995	COG3712	iron ion homeostasis
HPS43_RS17020	COG0642	Histidine kinase
HPS43_RS17030	COG2851	Citrate transporter
HPS43_RS17035	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS17055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPS43_RS17060	COG4191	Histidine kinase
HPS43_RS17060	COG0784	Response regulator, receiver
HPS43_RS17075	COG3604	Transcriptional regulator
HPS43_RS17080	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HPS43_RS17085	COG3813	Protein conserved in bacteria
HPS43_RS17090	COG2354	Protein conserved in bacteria
HPS43_RS17105	COG4772	TonB-dependent receptor
HPS43_RS17110	COG1522	sequence-specific DNA binding
HPS43_RS17130	COG4172	Belongs to the ABC transporter superfamily
HPS43_RS17140	COG0747	negative chemotaxis
HPS43_RS17160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_RS17175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPS43_RS17180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_RS17185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_RS17205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_RS17215	COG1309	transcriptional regulator
HPS43_RS17220	COG0583	DNA-binding transcription factor activity
HPS43_RS17240	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS43_RS17265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_RS17270	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS43_RS17275	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS43_RS17280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS43_RS17285	COG0649	NAD binding
HPS43_RS17290	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HPS43_RS17300	COG1034	ATP synthesis coupled electron transport
HPS43_RS17305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HPS43_RS17310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS43_RS17320	COG0713	ATP synthesis coupled electron transport
HPS43_RS17335	COG1007	ATP synthesis coupled electron transport
HPS43_RS17345	COG4774	siderophore transport
HPS43_RS17350	COG0560	Phosphoserine phosphatase
HPS43_RS17355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPS43_RS17360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPS43_RS17365	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPS43_RS17375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS43_RS17380	COG0450	alkyl hydroperoxide reductase
HPS43_RS17385	COG2205	protein histidine kinase activity
HPS43_RS17390	COG0745	RESPONSE REGULATOR receiver
HPS43_RS17395	COG1214	PFAM Peptidase M22, glycoprotease
HPS43_RS17400	COG1573	uracil-dna glycosylase
HPS43_RS17405	COG0477	Major facilitator Superfamily
HPS43_RS17410	COG1196	nuclear chromosome segregation
HPS43_RS17420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPS43_RS17425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_RS17435	COG2917	probably involved in intracellular septation
HPS43_RS17440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS43_RS17445	COG1122	ATPase activity
HPS43_RS17450	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPS43_RS17455	COG1268	BioY protein
HPS43_RS17490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPS43_RS17525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPS43_RS17530	COG2878	Part of a membrane complex involved in electron transport
HPS43_RS17545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPS43_RS17550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPS43_RS17555	COG0251	oxidation-reduction process
HPS43_RS17565	COG3228	Belongs to the MtfA family
HPS43_RS17570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPS43_RS17580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS43_RS17590	COG0159	tryptophan synthase activity
HPS43_RS17595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPS43_RS17600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HPS43_RS17605	COG1530	ribonuclease E activity
HPS43_RS17610	COG0564	pseudouridine synthase activity
HPS43_RS17615	COG0546	phosphoglycolate phosphatase activity
HPS43_RS17620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPS43_RS17625	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HPS43_RS17640	COG0424	maF-like protein
HPS43_RS17650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPS43_RS17660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS43_RS17665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPS43_RS17675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS43_RS17680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS43_RS17705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_RS17710	COG0481	GTPase activity
HPS43_RS17715	COG0681	Belongs to the peptidase S26 family
HPS43_RS17720	COG0571	ribonuclease III activity
HPS43_RS17725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPS43_RS17730	COG1381	Involved in DNA repair and RecF pathway recombination
HPS43_RS17780	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPS43_RS17805	COG0583	DNA-binding transcription factor activity
HPS43_RS17815	COG0791	NLP P60 protein
HPS43_RS17825	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HPS43_RS17835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS43_RS17840	COG0697	spore germination
HPS43_RS17845	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPS43_RS17870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_RS17895	COG2153	protein acetylation
HPS43_RS17905	COG1446	asparaginase
HPS43_RS17910	COG4172	Belongs to the ABC transporter superfamily
HPS43_RS17915	COG0747	negative chemotaxis
HPS43_RS17950	COG0504	CTP synthase activity
HPS43_RS17960	COG0148	phosphopyruvate hydratase activity
HPS43_RS17975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPS43_RS17985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS43_RS18040	COG0039	L-malate dehydrogenase activity
HPS43_RS18045	COG2188	Transcriptional regulator
HPS43_RS18050	COG2009	succinate dehydrogenase
HPS43_RS18055	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPS43_RS18060	COG1053	succinate dehydrogenase
HPS43_RS18065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPS43_RS18070	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPS43_RS18075	COG0372	Belongs to the citrate synthase family
HPS43_RS18090	COG0280	phosphate acetyltransferase
HPS43_RS18090	COG0281	malic enzyme
HPS43_RS18100	COG1297	OPT oligopeptide transporter protein
HPS43_RS18105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS43_RS18120	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HPS43_RS18125	COG1522	sequence-specific DNA binding
HPS43_RS18130	COG0567	Dehydrogenase, E1 component
HPS43_RS18135	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS43_RS18140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPS43_RS18145	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPS43_RS18150	COG1595	DNA-templated transcription, initiation
HPS43_RS18155	COG3712	iron ion homeostasis
HPS43_RS18160	COG4774	siderophore transport
HPS43_RS18195	COG2183	response to ionizing radiation
HPS43_RS18200	COG1199	ATP-dependent helicase activity
HPS43_RS18210	COG0564	pseudouridine synthase activity
HPS43_RS18220	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPS43_RS18225	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS18230	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HPS43_RS18255	COG2831	hemolysin activation secretion protein
HPS43_RS18280	COG2823	Periplasmic or secreted lipoprotein
HPS43_RS18290	COG3237	CsbD-like
HPS43_RS18295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS43_RS18295	COG0189	ligase activity
HPS43_RS18300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS43_RS18300	COG0189	ligase activity
HPS43_RS18305	COG1132	(ABC) transporter
HPS43_RS18320	COG2833	Protein of unknown function (DUF455)
HPS43_RS18325	COG2258	MOSC domain
HPS43_RS18330	COG2951	lytic endotransglycosylase activity
HPS43_RS18345	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS18355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPS43_RS18365	COG1696	Membrane protein involved in D-alanine export
HPS43_RS18385	COG1215	transferase activity, transferring glycosyl groups
HPS43_RS18395	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPS43_RS18420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPS43_RS18435	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPS43_RS18445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS43_RS18455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPS43_RS18460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPS43_RS18480	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPS43_RS18485	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPS43_RS18490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS43_RS18520	COG2951	lytic endotransglycosylase activity
HPS43_RS18525	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPS43_RS18550	COG2985	domain, Protein
HPS43_RS18555	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS18560	COG0450	alkyl hydroperoxide reductase
HPS43_RS18570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HPS43_RS18575	COG4208	sulfate ABC transporter
HPS43_RS18585	COG0175	sulfate reduction
HPS43_RS18615	COG0335	large ribosomal subunit rRNA binding
HPS43_RS18620	COG0494	nUDIX hydrolase
HPS43_RS18625	COG1162	GTPase activity
HPS43_RS18630	COG0501	Belongs to the peptidase M48B family
HPS43_RS18635	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPS43_RS18640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPS43_RS18645	COG3327	negative regulation of DNA-templated transcription, initiation
HPS43_RS18650	COG3396	Phenylacetate-CoA oxygenase
HPS43_RS18655	COG3460	Phenylacetate-CoA oxygenase
HPS43_RS18660	COG3396	Phenylacetate-CoA oxygenase
HPS43_RS18665	COG2151	metal-sulfur cluster biosynthetic enzyme
HPS43_RS18670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPS43_RS18675	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_RS18680	COG1024	Enoyl-CoA hydratase
HPS43_RS18685	COG2050	protein possibly involved in aromatic compounds catabolism
HPS43_RS18695	COG0534	Mate efflux family protein
HPS43_RS18710	COG3483	tryptophan 2,3-dioxygenase activity
HPS43_RS18715	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HPS43_RS18720	COG2003	Belongs to the UPF0758 family
HPS43_RS18730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPS43_RS18735	COG0625	glutathione transferase activity
HPS43_RS18740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS43_RS18745	COG0642	Histidine kinase
HPS43_RS18765	COG0523	cobalamin synthesis protein
HPS43_RS18770	COG0523	cobalamin synthesis protein
HPS43_RS18775	COG0583	DNA-binding transcription factor activity
HPS43_RS18790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HPS43_RS18795	COG1187	pseudouridine synthase activity
HPS43_RS18800	COG0779	Required for maturation of 30S ribosomal subunits
HPS43_RS18805	COG2251	uridine kinase activity
HPS43_RS18805	COG0195	Participates in both transcription termination and antitermination
HPS43_RS18810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPS43_RS18815	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPS43_RS18820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPS43_RS18845	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS18850	COG1473	amidohydrolase
HPS43_RS18855	COG1611	Belongs to the LOG family
HPS43_RS18870	COG0412	Dienelactone hydrolase
HPS43_RS18880	COG1760	l-serine dehydratase
HPS43_RS18885	COG0501	Belongs to the peptidase M48B family
HPS43_RS18905	COG0583	DNA-binding transcription factor activity
HPS43_RS18910	COG3842	ATPase activity
HPS43_RS18920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS43_RS18925	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS43_RS18945	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS18955	COG1722	exodeoxyribonuclease VII activity
HPS43_RS18960	COG0142	geranyltranstransferase activity
HPS43_RS18970	COG1469	GTP cyclohydrolase I activity
HPS43_RS18975	COG3739	integral membrane protein
HPS43_RS18980	COG0360	Binds together with S18 to 16S ribosomal RNA
HPS43_RS18985	COG2965	DNA replication, synthesis of RNA primer
HPS43_RS18990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPS43_RS18995	COG0359	binds to the 23S rRNA
HPS43_RS19005	COG0305	Participates in initiation and elongation during chromosome replication
HPS43_RS19020	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS43_RS19055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS19105	COG0540	Belongs to the ATCase OTCase family
HPS43_RS19130	COG0642	Histidine kinase
HPS43_RS19140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPS43_RS19145	COG2137	regulation of response to DNA damage stimulus
HPS43_RS19170	COG0045	succinate-CoA ligase (ADP-forming) activity
HPS43_RS19175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPS43_RS19180	COG0861	Integral membrane protein TerC family
HPS43_RS19185	COG0861	Integral membrane protein TerC family
HPS43_RS19190	COG0181	hydroxymethylbilane synthase activity
HPS43_RS19210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPS43_RS19220	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS19250	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_RS19270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPS43_RS19275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPS43_RS19285	COG0436	Aminotransferase
HPS43_RS19305	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HPS43_RS19310	COG0308	aminopeptidase N
HPS43_RS19325	COG0312	modulator of DNA gyrase
HPS43_RS19330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPS43_RS19335	COG0277	FAD linked oxidase domain protein
HPS43_RS19340	COG0277	FAD linked oxidase domain protein
HPS43_RS19345	COG0277	FAD linked oxidase domain protein
HPS43_RS19350	COG0247	lactate metabolic process
HPS43_RS19380	COG0583	DNA-binding transcription factor activity
HPS43_RS19385	COG0482	sulfurtransferase activity
HPS43_RS19390	COG0730	response to heat
HPS43_RS19395	COG0625	glutathione transferase activity
HPS43_RS19405	COG3909	cytochrome
HPS43_RS19445	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HPS43_RS19560	COG0697	spore germination
HPS43_RS19595	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HPS43_RS19605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS43_RS19610	COG0069	glutamate synthase activity
HPS43_RS19615	COG2391	methyltransferase activity
HPS43_RS19620	COG0679	Auxin Efflux Carrier
HPS43_RS19650	COG0557	exoribonuclease II activity
HPS43_RS19655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPS43_RS19665	COG3128	pkhd-type hydroxylase
HPS43_RS19670	COG0776	regulation of translation
HPS43_RS19695	COG0745	RESPONSE REGULATOR receiver
HPS43_RS19700	COG0642	Histidine kinase
HPS43_RS19705	COG3158	transport of potassium into the cell
HPS43_RS19710	COG0137	argininosuccinate synthase activity
HPS43_RS19715	COG0583	DNA-binding transcription factor activity
HPS43_RS19720	COG3618	amidohydrolase
HPS43_RS19740	COG2945	thiolester hydrolase activity
HPS43_RS19740	COG0596	Alpha beta hydrolase
HPS43_RS19745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPS43_RS19750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPS43_RS19770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_RS19775	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPS43_RS19785	COG3642	lipopolysaccharide core region biosynthetic process
HPS43_RS19795	COG3842	ATPase activity
HPS43_RS19800	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS43_RS19805	COG1177	transmembrane transport
HPS43_RS19825	COG1322	Protein conserved in bacteria
HPS43_RS19835	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS19845	COG0704	Plays a role in the regulation of phosphate uptake
HPS43_RS19855	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPS43_RS19860	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPS43_RS19860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPS43_RS19865	COG1643	Atp-dependent helicase
HPS43_RS19870	COG0395	ABC-type sugar transport system, permease component
HPS43_RS19875	COG1116	anion transmembrane transporter activity
HPS43_RS19890	COG0438	transferase activity, transferring glycosyl groups
HPS43_RS19895	COG0726	polysaccharide deacetylase
HPS43_RS19910	COG0726	polysaccharide deacetylase
HPS43_RS19935	COG1132	(ABC) transporter
HPS43_RS19940	COG0475	glutathione-regulated potassium exporter activity
HPS43_RS19940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPS43_RS19950	COG5001	Diguanylate cyclase
HPS43_RS19950	COG4251	negative regulation of phosphorylation
HPS43_RS19950	COG3706	GGDEF domain
HPS43_RS19950	COG2203	Gaf domain
HPS43_RS19960	COG1530	ribonuclease E activity
HPS43_RS19990	COG2204	response regulator
HPS43_RS19995	COG4191	Histidine kinase
HPS43_RS20000	COG1301	dicarboxylic acid transport
HPS43_RS20010	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPS43_RS20015	COG0799	negative regulation of ribosome biogenesis
HPS43_RS20020	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPS43_RS20030	COG0151	Belongs to the GarS family
HPS43_RS20035	COG0217	transcriptional regulatory protein
HPS43_RS20040	COG0433	COG0433 Predicted ATPase
HPS43_RS20045	COG0473	3-isopropylmalate dehydrogenase activity
HPS43_RS20055	COG2814	Major facilitator Superfamily
HPS43_RS20060	COG1566	PFAM secretion protein HlyD family protein
HPS43_RS20070	COG1846	Transcriptional regulator
HPS43_RS20100	COG3391	amine dehydrogenase activity
HPS43_RS20110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPS43_RS20130	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPS43_RS20135	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPS43_RS20145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPS43_RS20170	COG1309	transcriptional regulator
HPS43_RS20175	COG2311	Membrane
HPS43_RS20180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPS43_RS20205	COG0662	Cupin 2, conserved barrel domain protein
HPS43_RS20210	COG5285	phytanoyl-CoA dioxygenase
HPS43_RS20215	COG3217	Mosc domain protein beta barrel domain protein
HPS43_RS20215	COG0633	Ferredoxin
HPS43_RS20220	COG2076	Multidrug Resistance protein
HPS43_RS20235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_RS20250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPS43_RS20255	COG0425	Belongs to the sulfur carrier protein TusA family
HPS43_RS20265	COG0228	four-way junction DNA binding
HPS43_RS20275	COG0336	Belongs to the RNA methyltransferase TrmD family
HPS43_RS20280	COG1396	sequence-specific DNA binding
HPS43_RS20285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS20290	COG0765	amino acid transport
HPS43_RS20300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_RS20305	COG0525	valine-tRNA ligase activity
HPS43_RS20310	COG0105	UTP biosynthetic process
HPS43_RS20315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPS43_RS20335	COG2976	Protein conserved in bacteria
HPS43_RS20340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS43_RS20345	COG1160	GTP binding
HPS43_RS20350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS43_RS20355	COG1923	regulation of RNA biosynthetic process
HPS43_RS20360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPS43_RS20365	COG0330	HflC and HflK could
HPS43_RS20370	COG0330	HflC and HflK could
HPS43_RS20375	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HPS43_RS20380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPS43_RS20385	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPS43_RS20390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPS43_RS20410	COG0438	transferase activity, transferring glycosyl groups
HPS43_RS20420	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPS43_RS20420	COG2755	lipolytic protein G-D-S-L family
HPS43_RS20450	COG4964	Belongs to the GSP D family
HPS43_RS20480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPS43_RS20490	COG1295	ribonuclease BN
HPS43_RS20500	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPS43_RS20525	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPS43_RS20590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_RS20595	COG2274	protein secretion by the type I secretion system
HPS43_RS20605	COG1538	Outer membrane efflux protein
HPS43_RS20625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPS43_RS20635	COG0101	tRNA pseudouridine synthase activity
HPS43_RS20640	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS43_RS20660	COG0596	Alpha beta hydrolase
HPS43_RS20695	COG0129	dihydroxy-acid dehydratase activity
HPS43_RS20700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_RS20705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS43_RS20710	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPS43_RS20715	COG1609	Transcriptional regulator
HPS43_RS20735	COG4172	Belongs to the ABC transporter superfamily
HPS43_RS20740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_RS20745	COG0601	transmembrane transport
HPS43_RS20755	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_RS20785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPS43_RS20790	COG2197	response regulator
HPS43_RS20800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPS43_RS20805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPS43_RS20820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPS43_RS20825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPS43_RS20830	COG0004	ammonium transporteR
HPS43_RS20835	COG0347	Belongs to the P(II) protein family
HPS43_RS20845	COG2960	long-chain fatty acid transporting porin activity
HPS43_RS20855	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPS43_RS20860	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPS43_RS20865	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPS43_RS20870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS43_RS20870	COG0072	phenylalanine-tRNA ligase activity
HPS43_RS20900	COG2814	Major facilitator Superfamily
HPS43_RS20925	COG0384	phenazine biosynthesis protein PhzF
HPS43_RS20930	COG0456	acetyltransferase
HPS43_RS20965	COG1522	sequence-specific DNA binding
HPS43_RS20995	COG0583	DNA-binding transcription factor activity
HPS43_RS21000	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS21025	COG1116	anion transmembrane transporter activity
HPS43_RS21055	COG5265	(ABC) transporter
HPS43_RS21060	COG0656	L-ascorbic acid biosynthetic process
HPS43_RS21075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS43_RS21085	COG4977	sequence-specific DNA binding
HPS43_RS21085	COG1917	Cupin 2, conserved barrel domain protein
HPS43_RS21090	COG2223	nitrite transmembrane transporter activity
HPS43_RS21100	COG1215	transferase activity, transferring glycosyl groups
HPS43_RS21105	COG1649	PFAM Uncharacterised BCR, COG1649
HPS43_RS21105	COG0726	polysaccharide deacetylase
HPS43_RS21110	COG0457	Tetratricopeptide repeat
HPS43_RS21115	COG3706	GGDEF domain
HPS43_RS21140	COG1610	YqeY-like protein
HPS43_RS21145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS43_RS21150	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS21190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPS43_RS21200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS43_RS21205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS43_RS21230	COG1959	2 iron, 2 sulfur cluster binding
HPS43_RS21235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_RS21240	COG0697	spore germination
HPS43_RS21265	COG0583	DNA-binding transcription factor activity
HPS43_RS21270	COG0583	DNA-binding transcription factor activity
HPS43_RS21275	COG0625	glutathione transferase activity
HPS43_RS21290	COG2814	Major facilitator Superfamily
HPS43_RS21295	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS43_RS21310	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS21315	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS21355	COG3245	cytochrome
HPS43_RS21360	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPS43_RS21375	COG1280	lysine exporter protein (LysE YggA)
HPS43_RS21390	COG0697	spore germination
HPS43_RS21395	COG0697	spore germination
HPS43_RS21410	COG0534	Mate efflux family protein
HPS43_RS21415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPS43_RS21420	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS21430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS43_RS21435	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HPS43_RS21445	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS21480	COG2207	Transcriptional regulator
HPS43_RS21495	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS21500	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS21505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS43_RS21510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS43_RS21520	COG1304	FMN binding
HPS43_RS21540	COG3712	iron ion homeostasis
HPS43_RS21545	COG1595	DNA-templated transcription, initiation
HPS43_RS21570	COG1401	restriction endodeoxyribonuclease activity
HPS43_RS21600	COG3088	subunit of a heme lyase
HPS43_RS21605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_RS21615	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPS43_RS21630	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPS43_RS21635	COG4133	protoheme IX ABC transporter activity
HPS43_RS21655	COG3381	protein complex oligomerization
HPS43_RS21675	COG4235	cytochrome complex assembly
HPS43_RS21685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_RS21695	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPS43_RS21715	COG4133	protoheme IX ABC transporter activity
HPS43_RS21720	COG3005	denitrification pathway
HPS43_RS21725	COG3043	anaerobic respiration
HPS43_RS21745	COG3246	L-lysine catabolic process to acetate
HPS43_RS21750	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_RS21755	COG0583	DNA-binding transcription factor activity
HPS43_RS21765	COG0129	dihydroxy-acid dehydratase activity
HPS43_RS21770	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS21775	COG5001	Diguanylate cyclase
HPS43_RS21780	COG1024	Enoyl-CoA hydratase
HPS43_RS21810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_RS21820	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HPS43_RS21825	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS21830	COG0583	DNA-binding transcription factor activity
HPS43_RS21835	COG2610	gluconate transmembrane transporter activity
HPS43_RS21875	COG0235	Class ii aldolase
HPS43_RS21880	COG0477	Major facilitator Superfamily
HPS43_RS21895	COG2188	Transcriptional regulator
HPS43_RS21900	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS21940	COG1280	lysine exporter protein (LysE YggA)
HPS43_RS21945	COG5265	(ABC) transporter
HPS43_RS21955	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_RS21970	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS21975	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS22010	COG0583	DNA-binding transcription factor activity
HPS43_RS22020	COG0583	DNA-binding transcription factor activity
HPS43_RS22030	COG0583	DNA-binding transcription factor activity
HPS43_RS22055	COG2226	methyltransferase
HPS43_RS22065	COG2814	Major facilitator Superfamily
HPS43_RS22070	COG0154	amidase activity
HPS43_RS22105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS43_RS22125	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS22135	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_RS22140	COG0307	riboflavin synthase, alpha
HPS43_RS22150	COG2271	Major facilitator Superfamily
HPS43_RS22160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPS43_RS22170	COG0789	Transcriptional regulator
HPS43_RS22195	COG4774	siderophore transport
HPS43_RS22205	COG0022	dehydrogenase e1 component
HPS43_RS22225	COG0165	Argininosuccinate lyase
HPS43_RS22230	COG0668	transmembrane transport
HPS43_RS22300	COG2165	general secretion pathway protein
HPS43_RS22330	COG0583	DNA-binding transcription factor activity
HPS43_RS22340	COG0747	negative chemotaxis
HPS43_RS22345	COG0601	transmembrane transport
HPS43_RS22355	COG4172	Belongs to the ABC transporter superfamily
HPS43_RS22360	COG4681	YaeQ
HPS43_RS22375	COG0477	Major facilitator Superfamily
HPS43_RS22380	COG3161	chorismate lyase activity
HPS43_RS22385	COG1187	pseudouridine synthase activity
HPS43_RS22390	COG0583	DNA-binding transcription factor activity
HPS43_RS22415	COG1999	signal sequence binding
HPS43_RS22425	COG0339	signal peptide processing
HPS43_RS22430	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPS43_RS22435	COG4566	intracellular signal transduction
HPS43_RS22445	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPS43_RS22450	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS43_RS22455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPS43_RS22465	COG0583	DNA-binding transcription factor activity
HPS43_RS22485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS43_RS22485	COG4797	methyltransferase
HPS43_RS22490	COG1191	sigma factor activity
HPS43_RS22510	COG1360	Flagellar Motor Protein
HPS43_RS22515	COG0745	RESPONSE REGULATOR receiver
HPS43_RS22525	COG0835	chemotaxis
HPS43_RS22530	COG0840	transmembrane signaling receptor activity
HPS43_RS22535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPS43_RS22540	COG2201	protein-glutamate methylesterase activity
HPS43_RS22545	COG0745	RESPONSE REGULATOR receiver
HPS43_RS22550	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPS43_RS22555	COG0840	transmembrane signaling receptor activity
HPS43_RS22580	COG2747	anti-sigma28 factor FlgM
HPS43_RS22590	COG1815	bacterial-type flagellum-dependent cell motility
HPS43_RS22595	COG1558	bacterial-type flagellum-dependent cell motility
HPS43_RS22610	COG4787	bacterial-type flagellum-dependent cell motility
HPS43_RS22645	COG0840	transmembrane signaling receptor activity
HPS43_RS22660	COG0840	transmembrane signaling receptor activity
HPS43_RS22665	COG0840	transmembrane signaling receptor activity
HPS43_RS22700	COG1580	Controls the rotational direction of flagella during chemotaxis
HPS43_RS22725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPS43_RS22730	COG1766	The M ring may be actively involved in energy transduction
HPS43_RS22735	COG1677	Flagellar hook-basal body complex protein FliE
HPS43_RS22745	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPS43_RS22765	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPS43_RS22770	COG1334	flagellar protein FlaG
HPS43_RS22775	COG1414	Transcriptional regulator
HPS43_RS22785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_RS22790	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS22800	COG0285	dihydrofolate synthase activity
HPS43_RS22820	COG1451	nucleotide metabolic process
HPS43_RS22825	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPS43_RS22835	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPS43_RS22840	COG0024	Methionine aminopeptidase
HPS43_RS22845	COG0052	Belongs to the universal ribosomal protein uS2 family
HPS43_RS22850	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPS43_RS22855	COG0528	UMP kinase activity
HPS43_RS22860	COG0233	cytoplasmic translational termination
HPS43_RS22865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPS43_RS22875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPS43_RS22880	COG0750	zinc metalloprotease
HPS43_RS22885	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS43_RS22890	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPS43_RS22895	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPS43_RS22900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPS43_RS22915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPS43_RS22920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPS43_RS22940	COG2169	Transcriptional regulator
HPS43_RS22940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS43_RS22945	COG0519	Catalyzes the synthesis of GMP from XMP
HPS43_RS22945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS43_RS22965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPS43_RS22970	COG2867	negative regulation of translational initiation
HPS43_RS22975	COG2914	Belongs to the UPF0125 (RnfH) family
HPS43_RS22985	COG1024	Enoyl-CoA hydratase
HPS43_RS22985	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_RS23010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPS43_RS23015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPS43_RS23020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPS43_RS23025	COG0084	hydrolase, TatD family'
HPS43_RS23040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS23050	COG1126	abc transporter atp-binding protein
HPS43_RS23055	COG0010	Belongs to the arginase family
HPS43_RS23065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPS43_RS23075	COG0095	Lipoate-protein ligase
HPS43_RS23090	COG0625	glutathione transferase activity
HPS43_RS23100	COG1522	sequence-specific DNA binding
HPS43_RS23105	COG0386	Belongs to the glutathione peroxidase family
HPS43_RS23110	COG2814	Major facilitator Superfamily
HPS43_RS23130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS43_RS23140	COG0840	transmembrane signaling receptor activity
HPS43_RS23155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_RS23190	COG1902	pentaerythritol trinitrate reductase activity
HPS43_RS23220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPS43_RS23235	COG0842	Transport permease protein
HPS43_RS23240	COG1131	(ABC) transporter
HPS43_RS23255	COG2130	NADP-dependent
HPS43_RS23280	COG3842	ATPase activity
HPS43_RS23285	COG3842	ATPase activity
HPS43_RS23295	COG0395	ABC-type sugar transport system, permease component
HPS43_RS23335	COG0346	lactoylglutathione lyase activity
HPS43_RS23340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_RS23360	COG3634	alkyl hydroperoxide reductase activity
HPS43_RS23365	COG1959	2 iron, 2 sulfur cluster binding
HPS43_RS23370	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS23405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_RS23410	COG0420	3'-5' exonuclease activity
HPS43_RS23445	COG1006	Multisubunit Na H antiporter MnhC subunit
HPS43_RS23450	COG0651	ATP synthesis coupled electron transport
HPS43_RS23455	COG1863	multisubunit Na H antiporter MnhE subunit
HPS43_RS23460	COG2212	antiporter activity
HPS43_RS23465	COG1320	monovalent cation:proton antiporter activity
HPS43_RS23485	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPS43_RS23490	COG0488	(ABC) transporter
HPS43_RS23525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_RS23530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_RS23540	COG2252	PERMEase
HPS43_RS23545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPS43_RS23550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPS43_RS23585	COG0583	DNA-binding transcription factor activity
HPS43_RS23590	COG2814	Major facilitator Superfamily
HPS43_RS23595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPS43_RS23600	COG0789	Transcriptional regulator
HPS43_RS23615	COG0678	peroxiredoxin activity
HPS43_RS23615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPS43_RS23625	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPS43_RS23630	COG0584	glycerophosphoryl diester phosphodiesterase
HPS43_RS23640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_RS23650	COG4181	ATPase activity
HPS43_RS23660	COG1178	ABC-type Fe3 transport system permease component
HPS43_RS23665	COG3842	ATPase activity
HPS43_RS23670	COG0583	DNA-binding transcription factor activity
HPS43_RS23675	COG0560	Phosphoserine phosphatase
HPS43_RS23690	COG0583	DNA-binding transcription factor activity
HPS43_RS23705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS43_RS23720	COG0583	DNA-binding transcription factor activity
HPS43_RS23725	COG4336	lyase activity
HPS43_RS23755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_RS23775	COG2816	NAD+ diphosphatase activity
HPS43_RS23815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS23820	COG0765	amino acid transport
HPS43_RS23825	COG1126	abc transporter atp-binding protein
HPS43_RS23830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPS43_RS23835	COG1758	RNA polymerase activity
HPS43_RS23840	COG0194	GDP metabolic process
HPS43_RS23845	COG3258	Cytochrome c
HPS43_RS23850	COG2863	cytochrome
HPS43_RS23855	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS23865	COG2831	hemolysin activation secretion protein
HPS43_RS23870	COG3210	domain, Protein
HPS43_RS23880	COG0791	NLP P60 protein
HPS43_RS23895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPS43_RS23900	COG0833	amino acid
HPS43_RS23905	COG1561	YicC-like family, N-terminal region
HPS43_RS23910	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPS43_RS23920	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS23935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPS43_RS23940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPS43_RS23945	COG0174	glutamine synthetase
HPS43_RS23955	COG2204	response regulator
HPS43_RS23960	COG0583	DNA-binding transcription factor activity
HPS43_RS23965	COG1741	Belongs to the pirin family
HPS43_RS23970	COG1741	Belongs to the pirin family
HPS43_RS23975	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS23980	COG3842	ATPase activity
HPS43_RS23985	COG4149	molybdate abc transporter
HPS43_RS23990	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS43_RS24000	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS24015	COG0583	DNA-binding transcription factor activity
HPS43_RS24025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPS43_RS24035	COG0783	Belongs to the Dps family
HPS43_RS24045	COG0457	Tetratricopeptide repeat
HPS43_RS24050	COG0438	transferase activity, transferring glycosyl groups
HPS43_RS24075	COG1560	Kdo2-lipid A biosynthetic process
HPS43_RS24075	COG4783	chaperone-mediated protein folding
HPS43_RS24080	COG3866	Pectate lyase
HPS43_RS24095	COG0745	RESPONSE REGULATOR receiver
HPS43_RS24100	COG2205	protein histidine kinase activity
HPS43_RS24115	COG3842	ATPase activity
HPS43_RS24120	COG0395	ABC-type sugar transport system, permease component
HPS43_RS24125	COG1175	transmembrane transport
HPS43_RS24130	COG1653	transport
HPS43_RS24140	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPS43_RS24155	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS43_RS24180	COG1794	racemase activity, acting on amino acids and derivatives
HPS43_RS24185	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS43_RS24195	COG0583	DNA-binding transcription factor activity
HPS43_RS24200	COG0625	glutathione transferase activity
HPS43_RS24205	COG2133	pyrroloquinoline quinone binding
HPS43_RS24215	COG0697	spore germination
HPS43_RS24220	COG2363	Small membrane protein
HPS43_RS24240	COG0010	Belongs to the arginase family
HPS43_RS24250	COG1464	Belongs to the NlpA lipoprotein family
HPS43_RS24260	COG2814	Major facilitator Superfamily
HPS43_RS24270	COG1408	metallophosphoesterase
HPS43_RS24280	COG0688	phosphatidylethanolamine metabolic process
HPS43_RS24285	COG0488	(ABC) transporter
HPS43_RS24310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_RS24315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPS43_RS24320	COG3300	MHYT domain
HPS43_RS24320	COG5001	Diguanylate cyclase
HPS43_RS24335	COG2814	Major facilitator Superfamily
HPS43_RS24350	COG2814	Major facilitator Superfamily
HPS43_RS24355	COG4771	TonB-dependent receptor
HPS43_RS24375	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPS43_RS24380	COG2204	response regulator
HPS43_RS24415	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS24435	COG0693	protein deglycase activity
HPS43_RS24455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS43_RS24465	COG1289	transmembrane transporter activity
HPS43_RS24470	COG5001	Diguanylate cyclase
HPS43_RS24470	COG3300	MHYT domain
HPS43_RS24520	COG1253	flavin adenine dinucleotide binding
HPS43_RS24535	COG2205	protein histidine kinase activity
HPS43_RS24695	COG3706	GGDEF domain
HPS43_RS24700	COG0789	Transcriptional regulator
HPS43_RS24710	COG3706	GGDEF domain
HPS43_RS24740	COG1116	anion transmembrane transporter activity
HPS43_RS24745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_RS24750	COG4521	taurine ABC transporter
HPS43_RS24775	COG0793	Belongs to the peptidase S41A family
HPS43_RS24795	COG0628	permease
HPS43_RS24805	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPS43_RS24830	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS43_RS24835	COG4608	Belongs to the ABC transporter superfamily
HPS43_RS24840	COG0444	Belongs to the ABC transporter superfamily
HPS43_RS24850	COG0601	transmembrane transport
HPS43_RS24855	COG0747	negative chemotaxis
HPS43_RS24865	COG0251	oxidation-reduction process
HPS43_RS24885	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS43_RS24900	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS43_RS24915	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPS43_RS24925	COG3971	2-oxopent-4-enoate hydratase activity
HPS43_RS24955	COG0625	glutathione transferase activity
HPS43_RS24970	COG0477	Major facilitator Superfamily
HPS43_RS24980	COG0579	oxidoreductase
HPS43_RS24995	COG0625	glutathione transferase activity
HPS43_RS25020	COG0798	PFAM Bile acid sodium symporter
HPS43_RS25030	COG0640	Transcriptional regulator
HPS43_RS25040	COG0668	transmembrane transport
HPS43_RS25060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS43_RS25065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS43_RS25085	COG0583	DNA-binding transcription factor activity
HPS43_RS25090	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPS43_RS25110	COG1126	abc transporter atp-binding protein
HPS43_RS25115	COG0765	amino acid transport
HPS43_RS25120	COG4597	amino acid ABC transporter
HPS43_RS25125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS25130	COG0626	cystathionine gamma-synthase activity
HPS43_RS25135	COG0583	DNA-binding transcription factor activity
HPS43_RS25155	COG0444	Belongs to the ABC transporter superfamily
HPS43_RS25165	COG0601	transmembrane transport
HPS43_RS25170	COG0747	negative chemotaxis
HPS43_RS25180	COG0583	DNA-binding transcription factor activity
HPS43_RS25185	COG1335	isochorismatase
HPS43_RS25190	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS43_RS25200	COG2358	TRAP transporter, solute receptor (TAXI family
HPS43_RS25205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_RS25210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_RS25220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_RS25225	COG0519	Catalyzes the synthesis of GMP from XMP
HPS43_RS25225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS43_RS25235	COG1276	copper resistance
HPS43_RS25255	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS25260	COG3386	PFAM SMP-30 Gluconolaconase
HPS43_RS25265	COG2721	sulfolactate sulfo-lyase activity
HPS43_RS25285	COG0745	RESPONSE REGULATOR receiver
HPS43_RS25295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_RS25300	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HPS43_RS25305	COG3842	ATPase activity
HPS43_RS25310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS43_RS25325	COG0586	Pfam SNARE associated Golgi protein
HPS43_RS25330	COG0390	transport system, permease component
HPS43_RS25340	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HPS43_RS25385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_RS25390	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_RS25395	COG1120	ATPase activity
HPS43_RS25400	COG1126	abc transporter atp-binding protein
HPS43_RS25405	COG0765	amino acid transport
HPS43_RS25415	COG2070	2-Nitropropane dioxygenase
HPS43_RS25420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS43_RS25430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS43_RS25455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPS43_RS25460	COG0583	DNA-binding transcription factor activity
HPS43_RS25470	COG1846	Transcriptional regulator
HPS43_RS25480	COG4191	Histidine kinase
HPS43_RS25485	COG4566	intracellular signal transduction
HPS43_RS25520	COG0583	DNA-binding transcription factor activity
HPS43_RS25550	COG0765	amino acid transport
HPS43_RS25555	COG0436	Aminotransferase
HPS43_RS25580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HPS43_RS25605	COG0251	oxidation-reduction process
HPS43_RS25645	COG4948	Mandelate Racemase Muconate Lactonizing
HPS43_RS25655	COG1802	Transcriptional regulator
HPS43_RS25660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_RS25675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS43_RS25700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_RS25705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS43_RS25710	COG1116	anion transmembrane transporter activity
HPS43_RS25745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS25750	COG4597	amino acid ABC transporter
HPS43_RS25755	COG3154	lipid carrier protein
HPS43_RS25760	COG0826	peptidase U32
HPS43_RS25765	COG0826	peptidase U32
HPS43_RS25770	COG2197	response regulator
HPS43_RS25775	COG3850	Histidine kinase
HPS43_RS25780	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPS43_RS25785	COG0288	reversible hydration of carbon dioxide
HPS43_RS25790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPS43_RS25795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_RS25800	COG2181	nitrate reductase activity
HPS43_RS25805	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPS43_RS25810	COG1140	nitrate reductase beta subunit
HPS43_RS25820	COG2223	nitrite transmembrane transporter activity
HPS43_RS25845	COG0583	DNA-binding transcription factor activity
HPS43_RS25865	COG0583	DNA-binding transcription factor activity
HPS43_RS25875	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS25905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS25925	COG2070	2-Nitropropane dioxygenase
HPS43_RS25940	COG5002	protein histidine kinase activity
HPS43_RS25945	COG0745	RESPONSE REGULATOR receiver
HPS43_RS25950	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HPS43_RS25955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPS43_RS25965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS43_RS25970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS43_RS25985	COG0783	Belongs to the Dps family
HPS43_RS26015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS26020	COG0697	spore germination
HPS43_RS26025	COG2879	small protein
HPS43_RS26030	COG1966	Carbon starvation protein
HPS43_RS26055	COG0583	DNA-binding transcription factor activity
HPS43_RS26060	COG4521	taurine ABC transporter
HPS43_RS26065	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS43_RS26070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS43_RS26085	COG2274	protein secretion by the type I secretion system
HPS43_RS26090	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPS43_RS26105	COG3712	iron ion homeostasis
HPS43_RS26110	COG1595	DNA-templated transcription, initiation
HPS43_RS26115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS43_RS26125	COG0235	Class ii aldolase
HPS43_RS26130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS43_RS26140	COG0523	cobalamin synthesis protein
HPS43_RS26145	COG1228	amidohydrolase
HPS43_RS26150	COG4172	Belongs to the ABC transporter superfamily
HPS43_RS26155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_RS26160	COG0601	transmembrane transport
HPS43_RS26165	COG4166	transmembrane transport
HPS43_RS26180	COG1414	Transcriptional regulator
HPS43_RS26185	COG0513	Belongs to the DEAD box helicase family
HPS43_RS26190	COG0602	queuosine metabolic process
HPS43_RS26195	COG0720	synthase
HPS43_RS26205	COG1289	transmembrane transporter activity
HPS43_RS26215	COG1566	PFAM secretion protein HlyD family protein
HPS43_RS26230	COG0028	Belongs to the TPP enzyme family
HPS43_RS26240	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS26250	COG0400	carboxylic ester hydrolase activity
HPS43_RS26255	COG0833	amino acid
HPS43_RS26275	COG0587	DNA-directed DNA polymerase activity
HPS43_RS26295	COG0667	Aldo Keto reductase
HPS43_RS26305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPS43_RS26325	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS26370	COG3038	cytochrome b561
HPS43_RS26395	COG0840	transmembrane signaling receptor activity
HPS43_RS26475	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HPS43_RS26495	COG4774	siderophore transport
HPS43_RS26500	COG2345	Transcriptional regulator
HPS43_RS26510	COG1414	Transcriptional regulator
HPS43_RS26525	COG0667	Aldo Keto reductase
HPS43_RS26535	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS26540	COG1309	transcriptional regulator
HPS43_RS26560	COG1683	Conserved Protein
HPS43_RS26570	COG2207	Transcriptional regulator
HPS43_RS26590	COG3047	cAMP biosynthetic process
HPS43_RS26590	COG2885	chlorophyll binding
HPS43_RS26605	COG3795	YCII-related domain
HPS43_RS26610	COG3795	YCII-related domain
HPS43_RS26620	COG4941	Belongs to the sigma-70 factor family
HPS43_RS26630	COG0697	spore germination
HPS43_RS26640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS43_RS26650	COG0583	DNA-binding transcription factor activity
HPS43_RS26680	COG1846	Transcriptional regulator
HPS43_RS26685	COG3541	Predicted nucleotidyltransferase
HPS43_RS26705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS43_RS26755	COG1360	Flagellar Motor Protein
HPS43_RS26765	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HPS43_RS26815	COG3501	Rhs element vgr protein
HPS43_RS26875	COG3501	Rhs element vgr protein
HPS43_RS26970	COG0625	glutathione transferase activity
HPS43_RS26975	COG2032	superoxide dismutase activity
HPS43_RS26980	COG2733	membrane
HPS43_RS26990	COG0148	phosphopyruvate hydratase activity
HPS43_RS27015	COG0583	DNA-binding transcription factor activity
HPS43_RS27020	COG1024	Enoyl-CoA hydratase
HPS43_RS27020	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_RS27025	COG0183	Belongs to the thiolase family
HPS43_RS27030	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS27035	COG1960	acyl-CoA dehydrogenase activity
HPS43_RS27040	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS27050	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HPS43_RS27065	COG0583	DNA-binding transcription factor activity
HPS43_RS27075	COG1846	Transcriptional regulator
HPS43_RS27080	COG0477	Major facilitator Superfamily
HPS43_RS27085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPS43_RS27085	COG2010	Cytochrome c
HPS43_RS27090	COG2080	2 iron, 2 sulfur cluster binding
HPS43_RS27100	COG0596	Alpha beta hydrolase
HPS43_RS27105	COG2309	aminopeptidase activity
HPS43_RS27110	COG1335	isochorismatase
HPS43_RS27115	COG2010	Cytochrome c
HPS43_RS27115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPS43_RS27125	COG1522	sequence-specific DNA binding
HPS43_RS27130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS43_RS27135	COG3842	ATPase activity
HPS43_RS27140	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS43_RS27145	COG4149	molybdate abc transporter
HPS43_RS27150	COG5001	Diguanylate cyclase
HPS43_RS27150	COG3706	GGDEF domain
HPS43_RS27150	COG2203	Gaf domain
HPS43_RS27150	COG4251	negative regulation of phosphorylation
HPS43_RS27155	COG2201	protein-glutamate methylesterase activity
HPS43_RS27180	COG0840	transmembrane signaling receptor activity
HPS43_RS27200	COG0583	DNA-binding transcription factor activity
HPS43_RS27230	COG0456	acetyltransferase
HPS43_RS27245	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS27315	COG0165	Argininosuccinate lyase
HPS43_RS27330	COG0583	DNA-binding transcription factor activity
HPS43_RS27345	COG2205	protein histidine kinase activity
HPS43_RS27355	COG2267	carboxylic ester hydrolase activity
HPS43_RS27365	COG4221	oxidoreductase activity
HPS43_RS27370	COG2207	Transcriptional regulator
HPS43_RS27400	COG0640	Transcriptional regulator
HPS43_RS27405	COG0640	Transcriptional regulator
HPS43_RS27415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPS43_RS27420	COG0583	DNA-binding transcription factor activity
HPS43_RS27425	COG0431	NADPH-dependent FMN reductase
HPS43_RS27480	COG0519	Catalyzes the synthesis of GMP from XMP
HPS43_RS27480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS43_RS27505	COG0583	DNA-binding transcription factor activity
HPS43_RS27515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS43_RS27540	COG0583	DNA-binding transcription factor activity
HPS43_RS27545	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS27575	COG2072	flavoprotein involved in K transport
HPS43_RS27580	COG0601	transmembrane transport
HPS43_RS27585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS43_RS27595	COG4608	Belongs to the ABC transporter superfamily
HPS43_RS27600	COG0747	negative chemotaxis
HPS43_RS27645	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS43_RS27670	COG0583	DNA-binding transcription factor activity
HPS43_RS27725	COG5001	Diguanylate cyclase
HPS43_RS27730	COG4774	siderophore transport
HPS43_RS27745	COG0583	DNA-binding transcription factor activity
HPS43_RS27795	COG1953	Uracil, thiamine, allantoin
HPS43_RS27830	COG0583	DNA-binding transcription factor activity
HPS43_RS27835	COG0784	Response regulator, receiver
HPS43_RS27835	COG2198	Histidine kinase
HPS43_RS27835	COG2205	protein histidine kinase activity
HPS43_RS27835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS27840	COG3292	Two component regulator propeller
HPS43_RS27840	COG0745	RESPONSE REGULATOR receiver
HPS43_RS27840	COG2205	protein histidine kinase activity
HPS43_RS27870	COG0583	DNA-binding transcription factor activity
HPS43_RS27875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS43_RS27885	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS27895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPS43_RS27910	COG0583	DNA-binding transcription factor activity
HPS43_RS27935	COG0745	RESPONSE REGULATOR receiver
HPS43_RS27955	COG1595	DNA-templated transcription, initiation
HPS43_RS27960	COG3712	iron ion homeostasis
HPS43_RS27965	COG4774	siderophore transport
HPS43_RS27970	COG0047	phosphoribosylformylglycinamidine synthase activity
HPS43_RS27970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPS43_RS27985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_RS28025	COG0613	PHP domain protein
HPS43_RS28040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS43_RS28050	COG0583	DNA-binding transcription factor activity
HPS43_RS28060	COG0583	DNA-binding transcription factor activity
HPS43_RS28065	COG0477	Major facilitator Superfamily
HPS43_RS28070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS43_RS28080	COG0159	tryptophan synthase activity
HPS43_RS28105	COG0277	FAD linked oxidase domain protein
HPS43_RS28110	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS28120	COG3119	arylsulfatase activity
HPS43_RS28155	COG2149	membrane
HPS43_RS28165	COG3093	addiction module antidote protein HigA
HPS43_RS28190	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPS43_RS28200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPS43_RS28205	COG0459	protein refolding
HPS43_RS28240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPS43_RS28245	COG0714	Associated with various cellular activities
HPS43_RS28265	COG2304	oxidoreductase activity
HPS43_RS28280	COG3119	arylsulfatase activity
HPS43_RS28290	COG1280	lysine exporter protein (LysE YggA)
HPS43_RS28320	COG0633	Ferredoxin
HPS43_RS28325	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS28330	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS28335	COG4133	protoheme IX ABC transporter activity
HPS43_RS28340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPS43_RS28380	COG4604	ABC transporter, ATP-binding protein
HPS43_RS28385	COG4605	iron ion homeostasis
HPS43_RS28390	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS43_RS28395	COG4607	ABC-type enterochelin transport system periplasmic component
HPS43_RS28400	COG4771	TonB-dependent receptor
HPS43_RS28405	COG0745	RESPONSE REGULATOR receiver
HPS43_RS28415	COG0084	hydrolase, TatD family'
HPS43_RS28420	COG1136	(ABC) transporter
HPS43_RS28440	COG2271	Major facilitator Superfamily
HPS43_RS28450	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS28455	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPS43_RS28470	COG3135	benzoate transporter
HPS43_RS28475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPS43_RS28480	COG1309	transcriptional regulator
HPS43_RS28485	COG0183	Belongs to the thiolase family
HPS43_RS28490	COG1022	Amp-dependent synthetase and ligase
HPS43_RS28520	COG1024	Enoyl-CoA hydratase
HPS43_RS28530	COG1803	Methylglyoxal synthase
HPS43_RS28535	COG2975	iron-sulfur cluster assembly
HPS43_RS28540	COG0633	Ferredoxin
HPS43_RS28545	COG0443	Heat shock 70 kDa protein
HPS43_RS28550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPS43_RS28555	COG0316	Belongs to the HesB IscA family
HPS43_RS28560	COG0822	iron-sulfur transferase activity
HPS43_RS28565	COG1104	cysteine desulfurase activity
HPS43_RS28575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPS43_RS28580	COG0556	nucleotide-excision repair
HPS43_RS28590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPS43_RS28595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPS43_RS28600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPS43_RS28605	COG0740	serine-type endopeptidase activity
HPS43_RS28610	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPS43_RS28615	COG0501	Belongs to the peptidase M48B family
HPS43_RS28625	COG1278	Cold shock
HPS43_RS28635	COG1278	Cold shock
HPS43_RS28660	COG0251	oxidation-reduction process
HPS43_RS28670	COG0583	DNA-binding transcription factor activity
HPS43_RS28705	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPS43_RS28730	COG0277	FAD linked oxidase domain protein
HPS43_RS28745	COG2814	Major facilitator Superfamily
HPS43_RS28895	COG0740	serine-type endopeptidase activity
HPS43_RS29060	COG1475	DNA binding
HPS43_RS29125	COG2171	N-acyltransferase activity
HPS43_RS29135	COG2890	protein-(glutamine-N5) methyltransferase activity
HPS43_RS29140	COG0488	(ABC) transporter
HPS43_RS29155	COG4771	TonB-dependent receptor
HPS43_RS29160	COG4771	TonB-dependent receptor
HPS43_RS29165	COG4771	TonB-dependent receptor
HPS43_RS29175	COG1858	cytochrome C peroxidase
HPS43_RS29185	COG0210	DNA helicase
HPS43_RS29200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPS43_RS29200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS43_RS29205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPS43_RS29210	COG0196	riboflavin kinase activity
HPS43_RS29215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPS43_RS29220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPS43_RS29225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPS43_RS29275	COG1902	pentaerythritol trinitrate reductase activity
HPS43_RS29280	COG1126	abc transporter atp-binding protein
HPS43_RS29285	COG0765	amino acid transport
HPS43_RS29290	COG0765	amino acid transport
HPS43_RS29295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS43_RS29305	COG2423	ornithine cyclodeaminase activity
HPS43_RS29310	COG1764	response to oxidative stress
HPS43_RS29320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS43_RS29325	COG0625	glutathione transferase activity
HPS43_RS29335	COG4178	(ABC) transporter
HPS43_RS29345	COG4771	TonB-dependent receptor
HPS43_RS29360	COG2271	Major facilitator Superfamily
HPS43_RS29390	COG0506	proline dehydrogenase activity
HPS43_RS29390	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPS43_RS29390	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPS43_RS29400	COG3008	intermembrane lipid transfer
HPS43_RS29405	COG2995	paraquat-inducible protein a
HPS43_RS29415	COG4953	penicillin-binding protein 1C
HPS43_RS29420	COG2373	Large extracellular alpha-helical protein
HPS43_RS29425	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPS43_RS29430	COG1278	Cold shock
HPS43_RS29440	COG0183	Belongs to the thiolase family
HPS43_RS29445	COG0038	chloride channel
HPS43_RS29455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPS43_RS29465	COG1570	exodeoxyribonuclease VII activity
HPS43_RS29470	COG0811	peptide transport
HPS43_RS29480	COG1663	tetraacyldisaccharide 4'-kinase activity
HPS43_RS29490	COG2835	tetraacyldisaccharide 4'-kinase activity
HPS43_RS29495	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPS43_RS29500	COG0563	adenylate kinase activity
HPS43_RS29510	COG0728	peptidoglycan biosynthetic process
HPS43_RS29520	COG0268	Binds directly to 16S ribosomal RNA
HPS43_RS29525	COG0583	DNA-binding transcription factor activity
HPS43_RS29540	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS29545	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS43_RS29550	COG2186	Transcriptional regulator
HPS43_RS29560	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS29570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS43_RS29600	COG3384	dioxygenase
HPS43_RS29605	COG1012	belongs to the aldehyde dehydrogenase family
HPS43_RS29620	COG3971	2-oxopent-4-enoate hydratase activity
HPS43_RS29630	COG1028	Short-chain dehydrogenase reductase Sdr
HPS43_RS29635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPS43_RS29640	COG1562	ergosterol biosynthetic process
HPS43_RS29645	COG1562	ergosterol biosynthetic process
HPS43_RS29655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPS43_RS29680	COG1477	protein flavinylation
HPS43_RS29685	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPS43_RS29695	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS43_RS29710	COG5564	TIM-barrel signal transduction protein
HPS43_RS29715	COG5441	Belongs to the UPF0261 family
HPS43_RS29740	COG0542	response to heat
HPS43_RS29750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPS43_RS29760	COG0477	Major facilitator Superfamily
HPS43_RS29780	COG0494	nUDIX hydrolase
HPS43_RS29785	COG0583	DNA-binding transcription factor activity
HPS43_RS29790	COG0443	Heat shock 70 kDa protein
HPS43_RS29825	COG2814	Major facilitator Superfamily
HPS43_RS29835	COG3530	Putative quorum-sensing-regulated virulence factor
HPS43_RS29850	COG0625	glutathione transferase activity
HPS43_RS29875	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS29885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS43_RS29945	COG1522	sequence-specific DNA binding
HPS43_RS29955	COG4172	Belongs to the ABC transporter superfamily
HPS43_RS29980	COG0519	Catalyzes the synthesis of GMP from XMP
HPS43_RS30000	COG1595	DNA-templated transcription, initiation
HPS43_RS30020	COG0519	Catalyzes the synthesis of GMP from XMP
HPS43_RS30025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPS43_RS30030	COG2951	lytic endotransglycosylase activity
HPS43_RS30040	COG0583	DNA-binding transcription factor activity
HPS43_RS30050	COG2272	Belongs to the type-B carboxylesterase lipase family
HPS43_RS30055	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS30070	COG1473	amidohydrolase
HPS43_RS30080	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HPS43_RS30095	COG3618	amidohydrolase
HPS43_RS30100	COG3181	Tripartite tricarboxylate transporter family receptor
HPS43_RS30135	COG2011	ABC-type metal ion transport system permease component
HPS43_RS30140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPS43_RS30145	COG1464	Belongs to the NlpA lipoprotein family
HPS43_RS30155	COG2814	Major facilitator Superfamily
HPS43_RS30165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPS43_RS30170	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS43_RS30200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPS43_RS30200	COG0543	2 iron, 2 sulfur cluster binding
HPS43_RS30210	COG2837	iron assimilation
HPS43_RS30220	COG0583	DNA-binding transcription factor activity
HPS43_RS30225	COG2814	Major facilitator Superfamily
HPS43_RS30230	COG2169	Transcriptional regulator
HPS43_RS30260	COG1272	protein, Hemolysin III
HPS43_RS30270	COG1278	Cold shock
HPS43_RS30300	COG4638	Rieske (2fe-2S)
HPS43_RS30315	COG0604	alcohol dehydrogenase
HPS43_RS30315	COG3321	synthase
HPS43_RS30325	COG0318	PFAM AMP-dependent synthetase and ligase
HPS43_RS30330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS43_RS30355	COG0183	Belongs to the thiolase family
HPS43_RS30370	COG0842	Transport permease protein
HPS43_RS30375	COG1131	(ABC) transporter
HPS43_RS30395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS43_RS30425	COG0811	peptide transport