locus-tag class description HPS44_RS00035 ENOG4108K3A Glutathione S-transferase HPS44_RS00045 ENOG41082F9 transcriptional regulator HPS44_RS00050 ENOG410756H nucleotidyltransferase HPS44_RS00110 ENOG4105ER2 Ompa motb domain protein HPS44_RS00150 ENOG4105CS6 Rhs element vgr protein HPS44_RS00155 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPS44_RS00210 ENOG4105CS6 Rhs element vgr protein HPS44_RS00290 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPS44_RS00300 ENOG4108TGY Glutathione S-transferase HPS44_RS00305 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPS44_RS00310 ENOG4106BRA Membrane HPS44_RS00320 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HPS44_RS00345 ENOG4105CBN LysR family transcriptional regulator HPS44_RS00350 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_RS00355 ENOG4105CHU acetyl-coa acetyltransferase HPS44_RS00360 ENOG4105CC9 acyl-Coa dehydrogenase HPS44_RS00365 ENOG4105C1G acyl-Coa dehydrogenase HPS44_RS00370 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS00375 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HPS44_RS00395 ENOG4105F04 LysR family Transcriptional regulator HPS44_RS00405 ENOG4108VHT MarR family transcriptional regulator HPS44_RS00410 ENOG41079KZ Major Facilitator Superfamily HPS44_RS00415 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HPS44_RS00420 ENOG4108XHQ (2Fe-2S)-binding domain protein HPS44_RS00440 ENOG4108UAU isochorismatase HPS44_RS00445 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HPS44_RS00455 ENOG4105F7P transcriptional regulator AsnC family HPS44_RS00465 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS00475 ENOG4105E0C molybdate abc transporter HPS44_RS00485 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HPS44_RS00490 ENOG4105CBS Chea signal transduction histidine kinase HPS44_RS00500 ENOG4108KTQ Methyltransferase HPS44_RS00510 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS00515 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_RS00530 ENOG4105CC0 LysR family Transcriptional regulator HPS44_RS00550 ENOG4105F2V VRR-NUC domain-containing protein HPS44_RS00560 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HPS44_RS00595 ENOG4105C57 major facilitator superfamily HPS44_RS00630 ENOG4106IQC argininosuccinate lyase HPS44_RS00645 ENOG4105EJC lysr family transcriptional regulator HPS44_RS00650 ENOG4108Z6Z Transcriptional regulator HPS44_RS00660 ENOG4105JJR Histidine kinase HPS44_RS00680 ENOG4105R1U AraC Family Transcriptional Regulator HPS44_RS00685 ENOG4105D74 hydrolase HPS44_RS00695 ENOG4105EMU Dehydrogenase HPS44_RS00700 ENOG4105CF7 AraC family transcriptional regulator HPS44_RS00740 ENOG4105MHT Transcriptional regulator, ARSR family HPS44_RS00745 ENOG4105WAB arsR family transcriptional regulator HPS44_RS00755 ENOG4105DAE Methylenetetrahydrofolate reductase HPS44_RS00760 ENOG4105DZ2 Transcriptional regulator HPS44_RS00765 ENOG4108UZX fmn reductase HPS44_RS00810 ENOG4105CVR type I restriction-modification system HPS44_RS00815 ENOG4105C0D helicase HPS44_RS00820 ENOG4108I5C dEAD DEAH box helicase HPS44_RS00835 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPS44_RS00840 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HPS44_RS00865 ENOG4107RSM transcriptional regulator HPS44_RS00875 ENOG4105C5I Dehydrogenase HPS44_RS00895 ENOG4106NZI LysR family Transcriptional regulator HPS44_RS00905 ENOG4105DV0 amidase (EC 3.5.1.4 HPS44_RS00945 ENOG4105E1J oxidoreductase HPS44_RS00950 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_RS00955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS00960 ENOG4105C3U ABC transporter HPS44_RS00965 ENOG4108JQ7 (ABC) transporter HPS44_RS00970 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_RS01000 ENOG4105E0K tonB-dependent siderophore receptor HPS44_RS01005 ENOG4105E7U AraC family transcriptional regulator HPS44_RS01020 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HPS44_RS01040 ENOG4105CI0 Citrate lyase HPS44_RS01045 ENOG4105DND Transcriptional regulator HPS44_RS01065 ENOG4105CNM Receptor HPS44_RS01105 ENOG41060WC Enoyl-CoA hydratase HPS44_RS01110 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_RS01115 ENOG4105D2B acyl-CoA dehydrogenase HPS44_RS01125 ENOG4107F9Y LysR family transcriptional regulator HPS44_RS01130 ENOG4105GAK amidohydrolase 2 HPS44_RS01145 ENOG4107RT4 flavin reductase domain protein HPS44_RS01170 ENOG4108K0B C-di-gmp phosphodiesterase HPS44_RS01175 ENOG4105E0K tonB-dependent siderophore receptor HPS44_RS01180 ENOG4105E0K tonB-dependent siderophore receptor HPS44_RS01195 ENOG4105CBN LysR family transcriptional regulator HPS44_RS01220 ENOG4105ZRN HPS44_RS01235 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HPS44_RS01245 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HPS44_RS01270 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HPS44_RS01280 ENOG4105BZU Histidine kinase HPS44_RS01315 ENOG4107YNJ LysR family Transcriptional regulator HPS44_RS01320 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_RS01330 ENOG4105CHR reductase HPS44_RS01340 ENOG41082CG Protein CrcB homolog HPS44_RS01355 ENOG4107YNJ LysR family Transcriptional regulator HPS44_RS01380 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_RS01395 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS01400 ENOG4108ETH Formylglycinamide ribotide synthetase HPS44_RS01410 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_RS01415 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_RS01420 ENOG4108RRZ Transcription elongation factor GreB HPS44_RS01425 ENOG4105DB7 PHP domain protein HPS44_RS01440 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPS44_RS01450 ENOG4105DND Transcriptional regulator HPS44_RS01460 ENOG4105DUM transcriptional regulator, lysR family HPS44_RS01465 ENOG4105CSH Transporter HPS44_RS01470 ENOG4107S4Y M20 DapE family protein YgeY HPS44_RS01475 ENOG4108EC8 DNA internalization-related competence protein ComEC HPS44_RS01480 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HPS44_RS01490 ENOG4108MGI Transcriptional regulator HPS44_RS01505 ENOG4105CXG d-lactate dehydrogenase HPS44_RS01555 ENOG4105VG5 Membrane HPS44_RS01560 ENOG4105JP4 Inner membrane protein yidG HPS44_RS01580 ENOG4108X0B nad(p)h dehydrogenase (quinone) HPS44_RS01590 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HPS44_RS01595 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HPS44_RS01640 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HPS44_RS01675 ENOG4105ENH Sulfatase HPS44_RS01685 ENOG4105N14 lysine exporter protein LysE YggA HPS44_RS01715 ENOG4108ZIT Ferredoxin, 2FE-2S HPS44_RS01725 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HPS44_RS01745 ENOG4105EUZ Beta-lactamase domain protein HPS44_RS01755 ENOG4105E0K tonB-dependent siderophore receptor HPS44_RS01760 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HPS44_RS01765 ENOG4108IPW abc transporter atp-binding protein HPS44_RS01770 ENOG4105CM4 permease protein HPS44_RS01775 ENOG4105DHS permease protein HPS44_RS01785 ENOG4105D05 Receptor HPS44_RS01790 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPS44_RS01795 ENOG410804D Sensor Signal Transduction Histidine Kinase HPS44_RS01800 ENOG4105F8V Hydrolase, tatD family HPS44_RS01805 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HPS44_RS01820 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HPS44_RS01825 ENOG4105CSP Major Facilitator Superfamily HPS44_RS01835 ENOG410904N short-chain dehydrogenase reductase HPS44_RS01840 ENOG4105CRK lysyL-tRNA synthetase HPS44_RS01855 ENOG4105DKK Benzoate HPS44_RS01860 ENOG4105DFA alanine racemase domain protein HPS44_RS01870 ENOG4105CHU acetyl-coa acetyltransferase HPS44_RS01875 ENOG4108IQE Amp-dependent synthetase and ligase HPS44_RS01880 ENOG4108IV0 ABC, transporter HPS44_RS01900 ENOG4105C0Z ABC transporter HPS44_RS01905 ENOG4105CGU Enoyl-CoA hydratase HPS44_RS01915 ENOG4108Z5K methylglyoxal synthase HPS44_RS01920 ENOG4105WVQ Fe-S assembly protein IscX HPS44_RS01925 ENOG4108ZIT Ferredoxin, 2FE-2S HPS44_RS01930 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HPS44_RS01935 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HPS44_RS01940 ENOG4108Z4V iron-sulfur cluster assembly HPS44_RS01945 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HPS44_RS01950 ENOG4105C3J Cysteine desulfurase HPS44_RS01965 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HPS44_RS01970 ENOG4105CGF Aromatic amino acid aminotransferase HPS44_RS01975 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HPS44_RS01980 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HPS44_RS01985 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HPS44_RS01990 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HPS44_RS01995 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HPS44_RS02000 ENOG4108K0D peptidase, M48 HPS44_RS02005 ENOG4108TEB UPF0114 protein HPS44_RS02010 ENOG4105VEQ Cold shock protein HPS44_RS02020 ENOG4105VEQ Cold shock protein HPS44_RS02045 ENOG4105KME endoribonuclease L-psp HPS44_RS02055 ENOG4105EJC lysr family transcriptional regulator HPS44_RS02070 ENOG4108IG5 Transcriptional regulator HPS44_RS02090 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HPS44_RS02165 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HPS44_RS02175 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HPS44_RS02180 ENOG4105C5H ABC transporter HPS44_RS02195 ENOG4105PE1 Receptor HPS44_RS02200 ENOG4105PE1 Receptor HPS44_RS02205 ENOG4105PE1 Receptor HPS44_RS02225 ENOG4105C4R Atp-dependent dna helicase HPS44_RS02245 ENOG4108V3E phosphoribosylglycinamide formyltransferase HPS44_RS02250 ENOG4105DTN riboflavin biosynthesis protein ribF HPS44_RS02255 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HPS44_RS02260 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HPS44_RS02265 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HPS44_RS02285 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) HPS44_RS02320 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPS44_RS02350 ENOG4105CIF Ornithine Cyclodeaminase HPS44_RS02355 ENOG4108Z9K Osmotically inducible protein HPS44_RS02360 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HPS44_RS02370 ENOG4105CYM Glutathione S-transferase HPS44_RS02380 ENOG4105CQ0 ABC transporter HPS44_RS02390 ENOG4107ENK receptor HPS44_RS02405 ENOG4105DCM major facilitator superfamily HPS44_RS02410 ENOG4108IV0 ABC, transporter HPS44_RS02415 ENOG4105C0Z ABC transporter HPS44_RS02420 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_RS02425 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS02435 ENOG4105C26 Dehydrogenase HPS44_RS02445 ENOG4105DY2 Paraquat-inducible protein b HPS44_RS02450 ENOG4105F1S paraquat-inducible protein a HPS44_RS02460 ENOG4108JQB penicillin-binding protein 1C HPS44_RS02470 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HPS44_RS02475 ENOG4105VEQ Cold shock protein HPS44_RS02485 ENOG4105CHU acetyl-coa acetyltransferase HPS44_RS02490 ENOG4105CMQ Chloride channel HPS44_RS02495 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS02500 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPS44_RS02510 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HPS44_RS02525 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HPS44_RS02535 ENOG4105W49 UPF0434 protein HPS44_RS02540 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HPS44_RS02555 ENOG4105CJR Integral membrane protein (MviN HPS44_RS02565 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) HPS44_RS02570 ENOG4105RQF LysR family Transcriptional regulator HPS44_RS02580 ENOG4105CNV Aldolase HPS44_RS02590 ENOG4105DG4 malate L-lactate dehydrogenase HPS44_RS02595 ENOG4107YCY Transcriptional regulator HPS44_RS02615 ENOG4105C5I Dehydrogenase HPS44_RS02630 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HPS44_RS02645 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HPS44_RS02650 ENOG4105C26 Dehydrogenase HPS44_RS02675 ENOG4105CHR reductase HPS44_RS02680 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPS44_RS02700 ENOG4108ARY Protein CrcB homolog HPS44_RS02735 ENOG4105EQN UPF0261 protein HPS44_RS02760 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPS44_RS02770 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HPS44_RS02780 ENOG4105CSH Transporter HPS44_RS02800 ENOG4108YZ4 nudix hydrolase HPS44_RS02805 ENOG4105CR8 Transcriptional regulator HPS44_RS02810 ENOG4105R8A Heat shock protein HPS44_RS02825 ENOG4105CNM Receptor HPS44_RS02830 ENOG4105CNM Receptor HPS44_RS02835 ENOG4105WPR Transcriptional regulator, ARAC family HPS44_RS02855 ENOG4105VRT cytoplasmic protein HPS44_RS02870 ENOG4108TGY Glutathione S-transferase HPS44_RS02895 ENOG4105GAK amidohydrolase 2 HPS44_RS02910 ENOG4108JQ1 Dehydrogenase HPS44_RS02960 ENOG4108XM1 transcriptional regulator AsnC family HPS44_RS02970 ENOG4108JQ6 ABC transporter HPS44_RS02985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS02995 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPS44_RS03015 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPS44_RS03020 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HPS44_RS03025 ENOG4105CVE Lytic murein transglycosylase HPS44_RS03035 ENOG4105DDW LysR family Transcriptional regulator HPS44_RS03045 ENOG4105EBR Carboxylesterase HPS44_RS03065 ENOG4105CH2 amidohydrolase HPS44_RS03075 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) HPS44_RS03090 ENOG4105GAK amidohydrolase 2 HPS44_RS03100 ENOG4105BZU Histidine kinase HPS44_RS03105 ENOG4105VEJ Heat shock protein HPS44_RS03110 ENOG4105CSR polyphosphate kinase 2 HPS44_RS03130 ENOG4108UMI ABC transporter, permease HPS44_RS03135 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS03140 ENOG4105D01 (LipO)protein HPS44_RS03150 ENOG4105DNH Major Facilitator HPS44_RS03160 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HPS44_RS03165 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_RS03185 ENOG4105JAB phenazine biosynthesis protein, phzf family HPS44_RS03205 ENOG4105EZR dyp-type peroxidase family protein HPS44_RS03230 ENOG4105CBN LysR family transcriptional regulator HPS44_RS03235 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_RS03270 ENOG4108UT2 hemolysin iii HPS44_RS03295 ENOG4105DVW rieske (2Fe-2S) HPS44_RS03310 ENOG4108JA1 polyketide synthase HPS44_RS03325 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS03330 ENOG4108ERU trap dicarboxylate transporter subunit DctP HPS44_RS03340 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_RS03345 ENOG4108ZXC Two component transcriptional regulator, luxr family HPS44_RS03355 ENOG4105CHU acetyl-coa acetyltransferase HPS44_RS03370 ENOG4105E3A (ABC) transporter HPS44_RS03375 ENOG4105DA5 (ABC) transporter HPS44_RS03380 ENOG4105BZU Histidine kinase HPS44_RS03385 ENOG4105WH1 Two component transcriptional regulator luxr family HPS44_RS03400 ENOG4105D7T ABC transporter HPS44_RS03405 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HPS44_RS03425 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HPS44_RS03450 ENOG4105SG9 biopolymer transport protein, ExbD HPS44_RS03455 ENOG4105E02 MotA TolQ exbB proton channel HPS44_RS03520 ENOG4108S8N class II Aldolase HPS44_RS03540 ENOG4107RSM transcriptional regulator HPS44_RS03560 ENOG4105CN8 Transcriptional regulator HPS44_RS03575 ENOG4105CHR reductase HPS44_RS03585 ENOG4105GAK amidohydrolase 2 HPS44_RS03610 ENOG4105CGU Enoyl-CoA hydratase HPS44_RS03670 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPS44_RS03675 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HPS44_RS03695 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPS44_RS03700 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HPS44_RS03705 ENOG41083Z3 extracellular ligand-binding receptor HPS44_RS03710 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS03720 ENOG4105C0Z ABC transporter HPS44_RS03725 ENOG4108IV0 ABC, transporter HPS44_RS03760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_RS03765 ENOG4105BZU Histidine kinase HPS44_RS03780 ENOG4105CC0 LysR family Transcriptional regulator HPS44_RS03790 ENOG4105BZU Histidine kinase HPS44_RS03805 ENOG41061WM D-Alanyl-D-Alanine HPS44_RS03815 ENOG4105EXC Acyl-transferase HPS44_RS03830 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) HPS44_RS03860 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_RS03875 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_RS03880 ENOG41069H7 transport system small permease component HPS44_RS03885 ENOG4105CH5 extracellular solute-binding protein, family 7 HPS44_RS03900 ENOG4105ETE Transcriptional regulator (LacI family HPS44_RS03905 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_RS03910 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_RS03920 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HPS44_RS03935 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HPS44_RS03940 ENOG4105CSW GntR family transcriptional regulator HPS44_RS03955 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HPS44_RS03960 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HPS44_RS03975 ENOG4105CF7 AraC family transcriptional regulator HPS44_RS03980 ENOG4107U9B transcriptional regulator HPS44_RS03995 ENOG4105JAB phenazine biosynthesis protein, phzf family HPS44_RS04075 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HPS44_RS04080 ENOG4108R85 Short chain dehydrogenase HPS44_RS04085 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HPS44_RS04095 ENOG4108JJ7 ABC transporter HPS44_RS04115 ENOG4105D64 Mechanosensitive ion channel HPS44_RS04125 ENOG4107QP8 phosphohexose isomerase HPS44_RS04135 ENOG4108Z9Z response to DNA damage stimulus HPS44_RS04160 ENOG4105X23 Endonuclease Exonuclease phosphatase HPS44_RS04165 ENOG4105DZQ phospholipase D Transphosphatidylase HPS44_RS04170 ENOG4107UXM Membrane HPS44_RS04175 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HPS44_RS04180 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HPS44_RS04185 ENOG4105CG3 alpha amylase, catalytic region HPS44_RS04200 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HPS44_RS04205 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HPS44_RS04215 ENOG4105C85 amino acid HPS44_RS04230 ENOG4105DQE DNA ligase HPS44_RS04235 ENOG4105FDF Could be involved in DNA repair (By similarity) HPS44_RS04240 ENOG4105CEV competence damage-inducible protein HPS44_RS04250 ENOG4105BZU Histidine kinase HPS44_RS04280 ENOG4107S4Y M20 DapE family protein YgeY HPS44_RS04300 ENOG4105CSH Transporter HPS44_RS04310 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HPS44_RS04315 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HPS44_RS04330 ENOG4108W0P ABC transporter HPS44_RS04335 ENOG4105EHG Permease protein HPS44_RS04355 ENOG4108UAJ Transcriptional regulator HPS44_RS04380 ENOG4105J4Q Transcriptional regulator HPS44_RS04385 ENOG4105ERH Fumarylacetoacetate hydrolase HPS44_RS04390 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HPS44_RS04400 ENOG4105E2X shikimate dehydrogenase HPS44_RS04405 ENOG4108IUS Transketolase HPS44_RS04410 ENOG4108HHA Transketolase HPS44_RS04415 ENOG4108WYP Transcriptional regulator HPS44_RS04420 ENOG4105DCT glycerol dehydrogenase HPS44_RS04425 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HPS44_RS04430 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HPS44_RS04435 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HPS44_RS04445 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS04450 ENOG4105C0Z ABC transporter HPS44_RS04455 ENOG4108IV0 ABC, transporter HPS44_RS04465 ENOG4105CHR reductase HPS44_RS04480 ENOG4105JQN Transcriptional regulator HPS44_RS04495 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HPS44_RS04500 ENOG4105HEI LysR family (Transcriptional regulator HPS44_RS04505 ENOG4107QM5 aconitate hydratase HPS44_RS04510 ENOG4105UYK outer membrane protein a HPS44_RS04515 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HPS44_RS04530 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HPS44_RS04545 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_RS04615 ENOG4105BZU Histidine kinase HPS44_RS04635 ENOG4108JQ6 ABC transporter HPS44_RS04640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS04660 ENOG4105D7N magnesium and cobalt transport protein CorA HPS44_RS04680 ENOG4108JPW Aminotransferase HPS44_RS04685 ENOG4105C26 Dehydrogenase HPS44_RS04690 ENOG4105ECY inositol monophosphatase HPS44_RS04695 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HPS44_RS04700 ENOG4105D7W serine acetyltransferase HPS44_RS04705 ENOG4105CMR udp-glucose 4-epimerase HPS44_RS04710 ENOG4107QP8 phosphohexose isomerase HPS44_RS04715 ENOG4107QKV phosphomannomutase HPS44_RS04730 ENOG4105D3Q Sugar transferase HPS44_RS04735 ENOG4105FGF GDP-mannose mannosyl hydrolase HPS44_RS04740 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HPS44_RS04755 ENOG4105C30 Nad-dependent epimerase dehydratase HPS44_RS04775 ENOG4107T8Q Glycosyl transferase (Group 1 HPS44_RS04780 ENOG4106WTF Glycosyl transferase, family 2 HPS44_RS04785 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HPS44_RS04790 ENOG4106CD9 glycosyl transferase group 1 HPS44_RS04795 ENOG4105WH1 Two component transcriptional regulator luxr family HPS44_RS04800 ENOG4105WH1 Two component transcriptional regulator luxr family HPS44_RS04810 ENOG4108XG4 DNA-binding transcriptional regulator HPS44_RS04815 ENOG4107QPN acyl-Coa dehydrogenase HPS44_RS04825 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_RS04840 ENOG4105CHU acetyl-coa acetyltransferase HPS44_RS04855 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS04875 ENOG4105BZ1 (ABC) transporter HPS44_RS04880 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HPS44_RS04910 ENOG4105E39 Enoyl-CoA hydratase HPS44_RS04920 ENOG4105J4Q Transcriptional regulator HPS44_RS04925 ENOG4108T2C cysteine dioxygenase type I HPS44_RS04930 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HPS44_RS04950 ENOG4105HEI LysR family (Transcriptional regulator HPS44_RS04990 ENOG4108IJ6 ABC transporter HPS44_RS04995 ENOG4108RZE Tetr family transcriptional regulator HPS44_RS05010 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HPS44_RS05020 ENOG4105BZU Histidine kinase HPS44_RS05025 ENOG4105BZU Histidine kinase HPS44_RS05030 ENOG4105BZU Histidine kinase HPS44_RS05050 ENOG4105NQN cytochrome C HPS44_RS05065 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i HPS44_RS05085 ENOG4105C58 cytochrome c oxidase accessory protein ccog HPS44_RS05105 ENOG4105ED4 portal protein HPS44_RS05285 ENOG4105CFH Aspartokinase HPS44_RS05290 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HPS44_RS05295 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HPS44_RS05305 ENOG4105C8N cysteinyl-tRNA synthetase HPS44_RS05320 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HPS44_RS05325 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HPS44_RS05330 ENOG4105EE5 Membrane protein terC HPS44_RS05340 ENOG4105HEE Binding Domain protein HPS44_RS05345 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) HPS44_RS05355 ENOG4105CIG ABC transporter HPS44_RS05360 ENOG4108T0W nitrous oxide maturation protein NosY HPS44_RS05370 ENOG4105CJ2 (LipO)protein HPS44_RS05375 ENOG4105DFS Conserved Protein HPS44_RS05380 ENOG4105ECY inositol monophosphatase HPS44_RS05400 ENOG4105D64 Mechanosensitive ion channel HPS44_RS05440 ENOG4105GVF (ABC) transporter HPS44_RS05450 ENOG4108IY8 ABC, transporter HPS44_RS05485 ENOG4105WKW Pfam:DUF1458 HPS44_RS05495 ENOG4105CC0 LysR family Transcriptional regulator HPS44_RS05500 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HPS44_RS05550 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HPS44_RS05555 ENOG4105EZE Cupin 4 family protein HPS44_RS05565 ENOG4105GJM (LipO)protein HPS44_RS05570 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_RS05575 ENOG4108Z4T Peptidase M50 HPS44_RS05580 ENOG4107RTD sua5 ycio yrdc ywlc family protein HPS44_RS05585 ENOG4105CGZ zinc metallopeptidase HPS44_RS05645 ENOG4108Z7R Chaperone CsaA HPS44_RS05650 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HPS44_RS05660 ENOG4105GTN ParB Domain Protein Nuclease HPS44_RS05665 ENOG4105DHQ Histidine kinase HPS44_RS05670 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_RS05690 ENOG4108TTM chaperone HPS44_RS05705 ENOG4105BZU Histidine kinase HPS44_RS05710 ENOG4105BZU Histidine kinase HPS44_RS05715 ENOG41068CG regulatoR HPS44_RS05745 ENOG4108S1B Periplasmic chaperone protein HPS44_RS05750 ENOG4105E6S usher protein( HPS44_RS05790 ENOG4105BZP glycoside hydrolase 15-related HPS44_RS05805 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS05815 ENOG4108NIW Leucine export protein LeuE HPS44_RS05830 ENOG4105DZQ phospholipase D Transphosphatidylase HPS44_RS05850 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPS44_RS05865 ENOG4107XBN GntR Family Transcriptional Regulator HPS44_RS05875 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_RS05880 ENOG4105C0H protease HPS44_RS05910 ENOG4105E0F Histidine kinase HPS44_RS05915 ENOG4108ZHJ Organic hydroperoxide resistance protein HPS44_RS05920 ENOG4105RQF LysR family Transcriptional regulator HPS44_RS05930 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS05935 ENOG4105C3U ABC transporter HPS44_RS05955 ENOG4108Z9W Outer membrane porin HPS44_RS05960 ENOG4108KF1 Membrane HPS44_RS05965 ENOG4107SQD Transcriptional regulator, GntR family HPS44_RS05970 ENOG4105RHY Pfam:UPF0157 HPS44_RS06015 ENOG4105BZU Histidine kinase HPS44_RS06020 ENOG4105WEF catalase HPS44_RS06055 ENOG4108C33 Resolvase HPS44_RS06080 ENOG4105CJP fad dependent oxidoreductase HPS44_RS06085 ENOG4105DRP amino acid AbC transporter HPS44_RS06095 ENOG4105EAB amino acid AbC transporter HPS44_RS06105 ENOG4105C26 Dehydrogenase HPS44_RS06125 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HPS44_RS06150 ENOG4105C58 cytochrome c oxidase accessory protein ccog HPS44_RS06170 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i HPS44_RS06185 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPS44_RS06190 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HPS44_RS06225 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HPS44_RS06230 ENOG4105CA0 peroxidase HPS44_RS06235 ENOG4105EJC lysr family transcriptional regulator HPS44_RS06240 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HPS44_RS06250 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HPS44_RS06265 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HPS44_RS06270 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HPS44_RS06275 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_RS06280 ENOG4105BZS acriflavin resistance protein HPS44_RS06285 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPS44_RS06305 ENOG4105F4R Transcriptional regulator mode HPS44_RS06310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS06315 ENOG4105E0C molybdate abc transporter HPS44_RS06320 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPS44_RS06325 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HPS44_RS06360 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_RS06370 ENOG4105C7J ABC transporter, permease HPS44_RS06380 ENOG4105CPC Aldo Keto reductase HPS44_RS06390 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS06395 ENOG4105E39 Enoyl-CoA hydratase HPS44_RS06405 ENOG4105DRR Transcriptional regulator, GntR family HPS44_RS06415 ENOG4105CHU acetyl-coa acetyltransferase HPS44_RS06420 ENOG4105D2B acyl-CoA dehydrogenase HPS44_RS06425 ENOG4105D2B acyl-CoA dehydrogenase HPS44_RS06430 ENOG4105DUM transcriptional regulator, lysR family HPS44_RS06450 ENOG4105TW1 Carbohydrate-selective porin OprB HPS44_RS06455 ENOG4105DFW ABC transporter HPS44_RS06465 ENOG4108HWW ABC transporter HPS44_RS06470 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HPS44_RS06475 ENOG4105E9Z Nad-dependent epimerase dehydratase HPS44_RS06480 ENOG4105ETE Transcriptional regulator (LacI family HPS44_RS06490 ENOG4108IJ7 Glycine betaine HPS44_RS06495 ENOG4108HQS Glycine betaine HPS44_RS06505 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPS44_RS06510 ENOG4105C2C drug resistance transporter, Bcr CflA HPS44_RS06515 ENOG4105KDC 50s ribosomal protein l28 HPS44_RS06520 ENOG4105W0E 50S ribosomal protein L33 HPS44_RS06535 ENOG4105C0Z ABC transporter HPS44_RS06555 ENOG4105DZ1 carboxypeptidase HPS44_RS06565 ENOG4108VHT MarR family transcriptional regulator HPS44_RS06575 ENOG4105C8T Leucyl-tRNA synthetase HPS44_RS06590 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HPS44_RS06610 ENOG4105EUF amidase EC 3.5.1.4 HPS44_RS06620 ENOG4105C57 major facilitator superfamily HPS44_RS06630 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HPS44_RS06655 ENOG4105MP9 class II Aldolase HPS44_RS06695 ENOG4105ETT transcriptional Regulator, LysR family HPS44_RS06700 ENOG4105CYC Transferase HPS44_RS06705 ENOG4105CMU LysR family (Transcriptional regulator HPS44_RS06710 ENOG4105EGS Mechanosensitive ion channel HPS44_RS06740 ENOG4107SDU Methyl-accepting chemotaxis HPS44_RS06760 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS06770 ENOG4105D38 putrescine abc transporter HPS44_RS06775 ENOG4105CTU Proline racemase HPS44_RS06790 ENOG41080XP Cbs domain HPS44_RS06810 ENOG4107QIJ Aconitate hydratase 2 HPS44_RS06820 ENOG4105FQ6 thiopurine methyltransferase HPS44_RS06845 ENOG4105CPC Aldo Keto reductase HPS44_RS06850 ENOG4105CF7 AraC family transcriptional regulator HPS44_RS06860 ENOG4105K6V RNA polymerase HPS44_RS06875 ENOG4105Z2P Protein of unknown function (DUF465) HPS44_RS06890 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPS44_RS06895 ENOG4105CPK Glycosyl transferase (Group 1 HPS44_RS06910 ENOG4105D2S major facilitator superfamily HPS44_RS06915 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS06920 ENOG4105E2Z phosphate ABC transporter (Permease HPS44_RS06925 ENOG4105C8U phosphate abc transporter HPS44_RS06930 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HPS44_RS06940 ENOG4105C9X ppx gppa phosphatase HPS44_RS06950 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HPS44_RS06960 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPS44_RS06965 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HPS44_RS06970 ENOG4105HBR Rna-binding protein HPS44_RS06975 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HPS44_RS06980 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS06985 ENOG4105C2W permease HPS44_RS06995 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HPS44_RS07005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS07020 ENOG4105EMU Dehydrogenase HPS44_RS07030 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HPS44_RS07035 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HPS44_RS07050 ENOG4105BZU Histidine kinase HPS44_RS07055 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPS44_RS07070 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HPS44_RS07080 ENOG4105D2X ABC transporter substrate-binding protein HPS44_RS07085 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_RS07100 ENOG4107QMP dna polymerase iii subunits gamma and tau HPS44_RS07110 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HPS44_RS07130 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_RS07150 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_RS07165 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HPS44_RS07170 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS07185 ENOG41061WM D-Alanyl-D-Alanine HPS44_RS07205 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HPS44_RS07210 ENOG4108Z66 YbaK ebsC protein HPS44_RS07215 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPS44_RS07220 ENOG4105ETT transcriptional Regulator, LysR family HPS44_RS07225 ENOG4105C7K acetolactate synthase HPS44_RS07230 ENOG4105C1G acyl-Coa dehydrogenase HPS44_RS07270 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HPS44_RS07295 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS07305 ENOG4105C0Z ABC transporter HPS44_RS07310 ENOG4108IV0 ABC, transporter HPS44_RS07320 ENOG4107QXX ABC transporter HPS44_RS07335 ENOG4107QNJ CoA-transferase subunit B HPS44_RS07340 ENOG4107HP6 Transcriptional regulator HPS44_RS07345 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HPS44_RS07350 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HPS44_RS07355 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HPS44_RS07360 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HPS44_RS07370 ENOG4105C8V SAICAR synthetase HPS44_RS07390 ENOG4105CK2 sodium dicarboxylate symporter HPS44_RS07400 ENOG4105FD8 phosphonate metabolism protein PhnM HPS44_RS07405 ENOG4105HRV phosphonate c-p lyase system protein phnl HPS44_RS07410 ENOG4105ENV phosphonate C-P lyase system protein PhnK HPS44_RS07415 ENOG4105FT8 Phosphonate metabolism HPS44_RS07425 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HPS44_RS07430 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HPS44_RS07435 ENOG4107RJJ Transcriptional regulator HPS44_RS07440 ENOG4105FD8 phosphonate metabolism protein PhnM HPS44_RS07445 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HPS44_RS07450 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HPS44_RS07455 ENOG410811B TRANSCRIPTIONal HPS44_RS07460 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_RS07480 ENOG4105EHI Phosphonate ABC transporter, periplasmic HPS44_RS07485 ENOG4105D5T phosphonate abc transporter HPS44_RS07495 ENOG4105MHT Transcriptional regulator, ARSR family HPS44_RS07505 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HPS44_RS07515 ENOG4105DR5 peptidase HPS44_RS07525 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPS44_RS07535 ENOG4105CJ3 phosphate transporter HPS44_RS07560 ENOG4105M4B Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) HPS44_RS07570 ENOG4108SHQ Glutathione S-transferase HPS44_RS07590 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPS44_RS07595 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HPS44_RS07610 ENOG4105BZA Phosphoglycerate kinase HPS44_RS07615 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPS44_RS07620 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPS44_RS07630 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPS44_RS07645 ENOG4105C6K Malic enzyme HPS44_RS07670 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HPS44_RS07675 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HPS44_RS07690 ENOG4105TNS Conserved Protein HPS44_RS07700 ENOG4105D7T ABC transporter HPS44_RS07710 ENOG4105I5W Transporter HPS44_RS07715 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HPS44_RS07720 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HPS44_RS07725 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HPS44_RS07750 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HPS44_RS07755 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HPS44_RS07770 ENOG4105VIE preprotein translocase, subunit YajC HPS44_RS07775 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPS44_RS07780 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPS44_RS07800 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPS44_RS07820 ENOG4105C9A Phoh family HPS44_RS07825 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HPS44_RS07830 ENOG4108JU5 Magnesium and cobalt efflux protein HPS44_RS07835 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HPS44_RS07840 ENOG4107SET aldo keto reductase HPS44_RS07875 ENOG4108UAJ Transcriptional regulator HPS44_RS07885 ENOG4108TZV Membrane HPS44_RS07905 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HPS44_RS07915 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPS44_RS07925 ENOG4108ZAF Molybdopterin HPS44_RS07930 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPS44_RS07935 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPS44_RS07945 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPS44_RS07960 ENOG4107QIZ NADH dehydrogenase HPS44_RS07965 ENOG4108IEG Formate dehydrogenase Alpha subunit HPS44_RS07970 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HPS44_RS08005 ENOG4106NZI LysR family Transcriptional regulator HPS44_RS08010 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HPS44_RS08015 ENOG41068KF Universal stress protein HPS44_RS08025 ENOG4105IFJ Histidine kinase HPS44_RS08030 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_RS08045 ENOG4105E3J oxidoreductase HPS44_RS08060 ENOG4105CHR reductase HPS44_RS08080 ENOG4105C7F AcnD-accessory protein PrpF HPS44_RS08085 ENOG4105F04 LysR family Transcriptional regulator HPS44_RS08125 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HPS44_RS08130 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS08140 ENOG4105C0Z ABC transporter HPS44_RS08145 ENOG4108IV0 ABC, transporter HPS44_RS08155 ENOG4105E0K tonB-dependent siderophore receptor HPS44_RS08170 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPS44_RS08175 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPS44_RS08185 ENOG4108VPT UPF0234 protein HPS44_RS08190 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS08195 ENOG4105EHG Permease protein HPS44_RS08200 ENOG4107R4I Periplasmic binding protein HPS44_RS08205 ENOG4106QJH hemin transport protein HPS44_RS08215 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_RS08220 ENOG4108SF5 RNA Polymerase HPS44_RS08235 ENOG4105D29 Helix-turn-helix type 11 domain protein HPS44_RS08260 ENOG4105CBN LysR family transcriptional regulator HPS44_RS08265 ENOG4105C85 amino acid HPS44_RS08275 ENOG4105F7P transcriptional regulator AsnC family HPS44_RS08280 ENOG4108UT2 hemolysin iii HPS44_RS08285 ENOG4105KXX peptidase s58 dmpa HPS44_RS08290 ENOG4105EAB amino acid AbC transporter HPS44_RS08295 ENOG4105E5Q amino acid AbC transporter HPS44_RS08300 ENOG4105CDA abc transporter atp-binding protein HPS44_RS08305 ENOG4108K5P (LipO)protein HPS44_RS08335 ENOG4105TX3 Histidine kinase HPS44_RS08340 ENOG4108UYB regulatoR HPS44_RS08345 ENOG4105E2S oxidase) subunit II HPS44_RS08350 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPS44_RS08355 ENOG4105CCU oxidase (Subunit III) HPS44_RS08360 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HPS44_RS08400 ENOG4105C6K Malic enzyme HPS44_RS08415 ENOG4108PCN EamA-like transporter family HPS44_RS08435 ENOG4105DUM transcriptional regulator, lysR family HPS44_RS08450 ENOG4105CHR reductase HPS44_RS08460 ENOG4107NQ8 LysR family Transcriptional regulator HPS44_RS08480 ENOG4108JCI Transcriptional regulator HPS44_RS08485 ENOG4107RZC phospholipase d HPS44_RS08495 ENOG4105CF1 Alkylated DNA repair protein HPS44_RS08510 ENOG4105E6M Sulphatase-modifying factor protein HPS44_RS08525 ENOG4105F1J Homogentisate 1,2-dioxygenase HPS44_RS08530 ENOG4108302 MgtC SapB transporter HPS44_RS08535 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HPS44_RS08540 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HPS44_RS08555 ENOG4107QM5 aconitate hydratase HPS44_RS08570 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_RS08575 ENOG4108SF5 RNA Polymerase HPS44_RS08580 ENOG4108MP6 LysR family Transcriptional regulator HPS44_RS08585 ENOG4107GJV short-chain dehydrogenase reductase HPS44_RS08590 ENOG4105CNM Receptor HPS44_RS08610 ENOG4105BZU Histidine kinase HPS44_RS08615 ENOG4105EPW hflc protein HPS44_RS08630 ENOG4105D4Y metalloprotease HPS44_RS08640 ENOG4105DJ2 Major Facilitator Superfamily HPS44_RS08645 ENOG4105R1U AraC Family Transcriptional Regulator HPS44_RS08650 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HPS44_RS08660 ENOG4105DU1 integral membrane protein, terc HPS44_RS08665 ENOG41063Z6 transcriptional regulator, lysR family HPS44_RS08695 ENOG41067B5 Histone deacetylase superfamily protein HPS44_RS08715 ENOG4105CSH Transporter HPS44_RS08720 ENOG4105E2S oxidase) subunit II HPS44_RS08725 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPS44_RS08730 ENOG4105CCU oxidase (Subunit III) HPS44_RS08735 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HPS44_RS08745 ENOG4108Z9W Outer membrane porin HPS44_RS08750 ENOG4108Z9W Outer membrane porin HPS44_RS08755 ENOG4108Z9W Outer membrane porin HPS44_RS08765 ENOG4105E5M Multidrug resistance protein D HPS44_RS08820 ENOG4105HSS phospholipase C HPS44_RS08845 ENOG4107QZF nitrite reductase NADPH large subunit HPS44_RS08850 ENOG4107QZF nitrite reductase NADPH large subunit HPS44_RS08855 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HPS44_RS08865 ENOG4105CPC Aldo Keto reductase HPS44_RS08880 ENOG4105CV8 reductase HPS44_RS08885 ENOG4105HEI LysR family (Transcriptional regulator HPS44_RS08905 ENOG4105EJC lysr family transcriptional regulator HPS44_RS08910 ENOG4105CMJ mandelate racemase muconate lactonizing HPS44_RS08925 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS08930 ENOG410620I Diguanylate cyclase HPS44_RS08935 ENOG4105MHT Transcriptional regulator, ARSR family HPS44_RS08945 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HPS44_RS08950 ENOG4105C6X Major Facilitator HPS44_RS08980 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_RS08990 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HPS44_RS08995 ENOG4105K5X acetyltransferase HPS44_RS09000 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HPS44_RS09015 ENOG4108M0I Transcriptional regulator HPS44_RS09025 ENOG4105MP9 class II Aldolase HPS44_RS09070 ENOG4105PGM cation diffusion facilitator family transporter HPS44_RS09090 ENOG4105BZ1 (ABC) transporter HPS44_RS09100 ENOG4107QRT dEAD DEAH box helicase HPS44_RS09105 ENOG4107T0X DNA ligase HPS44_RS09110 ENOG4107T0X DNA ligase HPS44_RS09140 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HPS44_RS09145 ENOG4105C1G acyl-Coa dehydrogenase HPS44_RS09155 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_RS09160 ENOG4108PCN EamA-like transporter family HPS44_RS09165 ENOG4105CWC Acetylornithine deacetylase HPS44_RS09185 ENOG4105C5Q Transcriptional regulator HPS44_RS09190 ENOG410642W LysR family Transcriptional regulator HPS44_RS09215 ENOG4105F52 Transcriptional regulator HPS44_RS09220 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_RS09230 ENOG4105CMJ mandelate racemase muconate lactonizing HPS44_RS09240 ENOG4108Z9W Outer membrane porin HPS44_RS09245 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS09290 ENOG4108SF5 RNA Polymerase HPS44_RS09315 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPS44_RS09320 ENOG4105BZU Histidine kinase HPS44_RS09325 ENOG4105BZU Histidine kinase HPS44_RS09330 ENOG4107Z5C methylesterase HPS44_RS09335 ENOG4105BZU Histidine kinase HPS44_RS09375 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPS44_RS09405 ENOG4105BZU Histidine kinase HPS44_RS09425 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPS44_RS09430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_RS09440 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HPS44_RS09445 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HPS44_RS09455 ENOG4108U05 Transcriptional regulator HPS44_RS09470 ENOG4105DUM transcriptional regulator, lysR family HPS44_RS09500 ENOG4108IUZ ABC transporter HPS44_RS09505 ENOG4108IV0 ABC, transporter HPS44_RS09510 ENOG4105DEI Mannitol dehydrogenase HPS44_RS09515 ENOG41080IJ Diacylglycerol kinase HPS44_RS09520 ENOG4105CEP NADH dehydrogenase HPS44_RS09525 ENOG4105SKN orotidine 5''-phosphate decarboxylase HPS44_RS09530 ENOG4107TH8 cina domain protein HPS44_RS09540 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HPS44_RS09545 ENOG4107YIM Involved in the transcription termination process (By similarity) HPS44_RS09550 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HPS44_RS09555 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HPS44_RS09575 ENOG4105D5T phosphonate abc transporter HPS44_RS09600 ENOG4106H78 methyltransferase HPS44_RS09605 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HPS44_RS09610 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HPS44_RS09615 ENOG4105DKK Benzoate HPS44_RS09650 ENOG4105CNM Receptor HPS44_RS09655 ENOG4105DFS Conserved Protein HPS44_RS09660 ENOG4105C3G gtp-binding protein HPS44_RS09670 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HPS44_RS09690 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HPS44_RS09695 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS09705 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein HPS44_RS09710 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HPS44_RS09735 ENOG4105F1J Homogentisate 1,2-dioxygenase HPS44_RS09745 ENOG4106HNH Acyl-transferase HPS44_RS09750 ENOG4105E0M Sulfatase HPS44_RS09755 ENOG4107YCY Transcriptional regulator HPS44_RS09760 ENOG4105E9Z Nad-dependent epimerase dehydratase HPS44_RS09770 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_RS09780 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_RS09790 ENOG4105BZU Histidine kinase HPS44_RS09795 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_RS09800 ENOG4105CQB FAD linked oxidase domain protein HPS44_RS09815 ENOG4107QP8 phosphohexose isomerase HPS44_RS09820 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_RS09825 ENOG4105CGN Glycosyl transferase (Group 1 HPS44_RS09830 ENOG4108KMV Glycosyl transferase (Group 1 HPS44_RS09835 ENOG4107STW synthase HPS44_RS09845 ENOG4105CG5 Glycosyl transferase (Group 1 HPS44_RS09860 ENOG4107QQG Dehydrogenase HPS44_RS09865 ENOG4107UKG Glycosyl transferase, family 4 HPS44_RS09885 ENOG4105BZU Histidine kinase HPS44_RS09895 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_RS09900 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPS44_RS09905 ENOG4105C26 Dehydrogenase HPS44_RS09930 ENOG4108JQ6 ABC transporter HPS44_RS09935 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_RS09975 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HPS44_RS09980 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HPS44_RS09985 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HPS44_RS09995 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPS44_RS10000 ENOG4105CBX hi0933 family HPS44_RS10005 ENOG4105CXN decarboxylase HPS44_RS10020 ENOG4105BZU Histidine kinase HPS44_RS10030 ENOG4105DHP deoxycytidine triphosphate deaminase HPS44_RS10055 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HPS44_RS10060 ENOG4105C72 UPF0176 protein HPS44_RS10075 ENOG4105EXC Acyl-transferase HPS44_RS10085 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_RS10090 ENOG4107SVH Potassium channel protein HPS44_RS10095 ENOG4105CXC rtn protein HPS44_RS10100 ENOG4108SF5 RNA Polymerase HPS44_RS10110 ENOG4105E0K tonB-dependent siderophore receptor HPS44_RS10120 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class HPS44_RS10125 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_RS10130 ENOG4105D0S secretion protein (HlyD HPS44_RS10135 ENOG4105CJ1 ABC, transporter HPS44_RS10140 ENOG4105CMI transporter HPS44_RS10150 ENOG4105CHR reductase HPS44_RS10155 ENOG4105CC0 LysR family Transcriptional regulator HPS44_RS10160 ENOG4108KTG Membrane protein, drug metabolite transporter HPS44_RS10170 ENOG4105C4M (Ubiquinol oxidase) subunit I HPS44_RS10175 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPS44_RS10185 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_RS10205 ENOG41079YP Citrate utilization protein b HPS44_RS10220 ENOG4105NQN cytochrome C HPS44_RS10230 ENOG4105CYM Glutathione S-transferase HPS44_RS10235 ENOG4105C84 Histidine ammonia-lyase HPS44_RS10240 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HPS44_RS10245 ENOG4105CSH Transporter HPS44_RS10250 ENOG4105CGP Urocanate hydratase HPS44_RS10265 ENOG4105CD3 dihydroorotase HPS44_RS10290 ENOG4105YK5 50S ribosomal protein L36 HPS44_RS10300 ENOG4108I0Z Aconitate hydratase HPS44_RS10305 ENOG4105C7F AcnD-accessory protein PrpF HPS44_RS10310 ENOG4108SF5 RNA Polymerase HPS44_RS10315 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_RS10320 ENOG4105CNM Receptor HPS44_RS10325 ENOG4105CH7 arginosuccinase HPS44_RS10330 ENOG4105JJR Histidine kinase HPS44_RS10335 ENOG4105CHR reductase HPS44_RS10340 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme HPS44_RS10355 ENOG4105EVD ribosomal RNA large subunit methyltransferase N HPS44_RS10360 ENOG4105JSC dimethylmenaquinone methyltransferase HPS44_RS10365 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_RS10370 ENOG4105BZN citrate synthase HPS44_RS10375 ENOG4105CXK mandelate racemase muconate lactonizing HPS44_RS10400 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HPS44_RS10405 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_RS10415 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HPS44_RS10425 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HPS44_RS10435 ENOG4109066 lysm domain bon superfamily protein HPS44_RS10440 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HPS44_RS10445 ENOG4105CRE cytochrome C HPS44_RS10455 ENOG4108TGY Glutathione S-transferase HPS44_RS10485 ENOG4105C26 Dehydrogenase HPS44_RS10495 ENOG4105DFG type I secretion outer membrane protein HPS44_RS10500 ENOG4107QZV Type I secretion membrane fusion protein HPS44_RS10505 ENOG4108JJ6 Type I secretion system ATPase HPS44_RS10535 ENOG4107HP6 Transcriptional regulator HPS44_RS10545 ENOG4108RTU Aldolase HPS44_RS10550 ENOG4105CXK mandelate racemase muconate lactonizing HPS44_RS10555 ENOG4105DJB Major Facilitator Superfamily HPS44_RS10560 ENOG4105CJ1 ABC, transporter HPS44_RS10580 ENOG4105F27 Major Facilitator HPS44_RS10585 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HPS44_RS10595 ENOG4105C2W permease HPS44_RS10625 ENOG4108R1E Serine threonine protein phosphatase 1 HPS44_RS10690 ENOG4105VUH addiction module killer protein HPS44_RS10705 ENOG4107QXX ABC transporter HPS44_RS10715 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HPS44_RS10730 ENOG4105CHR reductase HPS44_RS10840 ENOG4105BZU Histidine kinase HPS44_RS10845 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_RS10850 ENOG4105I6B RNA polymerase HPS44_RS10870 ENOG4106NZI LysR family Transcriptional regulator HPS44_RS10880 ENOG4105NTW Transcriptional regulator HPS44_RS10900 ENOG4105II7 pyrroline-5-carboxylate reductase HPS44_RS10910 ENOG4105CQB FAD linked oxidase domain protein HPS44_RS10920 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS10925 ENOG4105F38 ABC transporter, permease HPS44_RS10930 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_RS10945 ENOG4105IPI Membrane HPS44_RS10950 ENOG4105CBN LysR family transcriptional regulator HPS44_RS10955 ENOG4105ENT Efflux transporter rnd family, mfp subunit HPS44_RS10965 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_RS11005 ENOG4105GP2 5'(3')-deoxyribonucleotidase HPS44_RS11015 ENOG4107YCY Transcriptional regulator HPS44_RS11025 ENOG4105E2X shikimate dehydrogenase HPS44_RS11035 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS11045 ENOG4105C0Z ABC transporter HPS44_RS11050 ENOG4108IV0 ABC, transporter HPS44_RS11060 ENOG4108JYK Dehydrogenase HPS44_RS11080 ENOG4105HEI LysR family (Transcriptional regulator HPS44_RS11085 ENOG4105C01 Dihydroxy-acid dehydratase HPS44_RS11095 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HPS44_RS11100 ENOG4105DUM transcriptional regulator, lysR family HPS44_RS11115 ENOG4105CXC rtn protein HPS44_RS11120 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HPS44_RS11125 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HPS44_RS11130 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_RS11135 ENOG4105CRW Short chain fatty acid transporter HPS44_RS11140 ENOG4105CHR reductase HPS44_RS11145 ENOG4107HP6 Transcriptional regulator HPS44_RS11155 ENOG4107QNJ CoA-transferase subunit B HPS44_RS11170 ENOG4105F2Z 3-oxoadipate enol-lactonase HPS44_RS11195 ENOG4108PVQ transcriptional regulator HPS44_RS11200 ENOG4105CHR reductase HPS44_RS11210 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS11215 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_RS11220 ENOG4105C0Z ABC transporter HPS44_RS11225 ENOG4108IV0 ABC, transporter HPS44_RS11235 ENOG4105CHR reductase HPS44_RS11240 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HPS44_RS11245 ENOG4108U78 Glutathione S-transferase HPS44_RS11270 ENOG4107NQ8 LysR family Transcriptional regulator HPS44_RS11275 ENOG4105C57 major facilitator superfamily HPS44_RS11300 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS11320 ENOG4105D01 (LipO)protein HPS44_RS11330 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HPS44_RS11340 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPS44_RS11345 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HPS44_RS11360 ENOG410829K Lysine exporter protein (Lyse ygga) HPS44_RS11385 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HPS44_RS11390 ENOG4105UGU tonB-dependent Receptor HPS44_RS11400 ENOG4105CSH Transporter HPS44_RS11405 ENOG4105DDW LysR family Transcriptional regulator HPS44_RS11410 ENOG4107YCY Transcriptional regulator HPS44_RS11415 ENOG4105G63 Type III effector Hrp-dependent HPS44_RS11420 ENOG4105ZXK Dehydrogenase HPS44_RS11425 ENOG4105EXW epimerase dehydratase HPS44_RS11430 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HPS44_RS11435 ENOG4105FB2 class II Aldolase HPS44_RS11505 ENOG4105EAH synthase HPS44_RS11510 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HPS44_RS11515 ENOG4105K46 50S ribosomal protein l27 HPS44_RS11520 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HPS44_RS11525 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HPS44_RS11540 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPS44_RS11545 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HPS44_RS11555 ENOG4108QBF Transcriptional regulator HPS44_RS11560 ENOG4105BZU Histidine kinase HPS44_RS11565 ENOG4105D06 uba thif-type nad fad binding protein HPS44_RS11570 ENOG4105CN1 protease HPS44_RS11575 ENOG41063SB peptidase HPS44_RS11580 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HPS44_RS11585 ENOG4105C72 UPF0176 protein HPS44_RS11590 ENOG4105VW4 glutaredoxin 3 HPS44_RS11595 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HPS44_RS11600 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HPS44_RS11615 ENOG4105MJ2 Competence protein HPS44_RS11620 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPS44_RS11625 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HPS44_RS11630 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HPS44_RS11635 ENOG4105C1A potassium transporter peripheral membrane HPS44_RS11640 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_RS11645 ENOG4105ES5 Histidine kinase HPS44_RS11655 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HPS44_RS11660 ENOG410829K Lysine exporter protein (Lyse ygga) HPS44_RS11665 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HPS44_RS11675 ENOG4105KVH Transcriptional regulator HPS44_RS11685 ENOG4108URH decarboxylase HPS44_RS11695 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 HPS44_RS11705 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HPS44_RS11710 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HPS44_RS11715 ENOG4105C79 DNA protecting protein DprA HPS44_RS11720 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HPS44_RS11730 ENOG4107QXX ABC transporter HPS44_RS11735 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_RS11740 ENOG4105DFA alanine racemase domain protein HPS44_RS11760 ENOG4105W39 Membrane HPS44_RS11765 ENOG4105C7B Threonine dehydratase HPS44_RS11770 ENOG4108Z9W Outer membrane porin HPS44_RS11780 ENOG4105EXG Transcriptional regulator HPS44_RS11785 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HPS44_RS11790 ENOG4108JJ8 (ABC) transporter HPS44_RS11795 ENOG4108JJ9 ABC, transporter HPS44_RS11805 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPS44_RS11810 ENOG4105C4M (Ubiquinol oxidase) subunit I HPS44_RS11820 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HPS44_RS11825 ENOG4105C2X Arabinose 5-phosphate isomerase HPS44_RS11830 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HPS44_RS11845 ENOG4108IUZ ABC transporter HPS44_RS11850 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HPS44_RS11855 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HPS44_RS11860 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HPS44_RS11865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_RS11880 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HPS44_RS11890 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPS44_RS11900 ENOG41082RQ UPF0102 protein HPS44_RS11905 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HPS44_RS11910 ENOG4105W4M Transport-associated protein HPS44_RS11915 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPS44_RS11920 ENOG4105D01 (LipO)protein HPS44_RS11925 ENOG4105CAS nag kinase HPS44_RS11935 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HPS44_RS11940 ENOG4107QPK )-transporter HPS44_RS11945 ENOG4105DG4 malate L-lactate dehydrogenase HPS44_RS11950 ENOG4105CNI cell division protein FtsW HPS44_RS11955 ENOG4105CJN penicillin-binding protein HPS44_RS11965 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HPS44_RS11975 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HPS44_RS11980 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_RS11985 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HPS44_RS12000 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HPS44_RS12005 ENOG4105CGK Exodeoxyribonuclease III HPS44_RS12010 ENOG4105D82 Glutamate dehydrogenase HPS44_RS12020 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HPS44_RS12035 ENOG410810E transcriptional regulator, lysR family HPS44_RS12040 ENOG4105CP9 extracellular ligand-binding receptor HPS44_RS12050 ENOG4105C0Z ABC transporter HPS44_RS12055 ENOG4108IV0 ABC, transporter HPS44_RS12060 ENOG4108ZHJ Organic hydroperoxide resistance protein HPS44_RS12065 ENOG4105K56 Transcriptional regulator HPS44_RS12080 ENOG4105C0Z ABC transporter HPS44_RS12085 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS12100 ENOG4108IV0 ABC, transporter HPS44_RS12105 ENOG4105DZS Phenylacetate-CoA ligase HPS44_RS12125 ENOG41080HT Transcriptional regulator, arsr family HPS44_RS12135 ENOG4105CSR polyphosphate kinase 2 HPS44_RS12155 ENOG4105K78 MarR family Transcriptional regulator HPS44_RS12170 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HPS44_RS12180 ENOG4105DWF phosphomethylpyrimidine kinase HPS44_RS12215 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HPS44_RS12220 ENOG4105C1J atp-dependent rna helicase HPS44_RS12230 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HPS44_RS12235 ENOG4107SC1 transglycosylase HPS44_RS12240 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HPS44_RS12270 ENOG4105SYT Methylenetetrahydrofolate reductase HPS44_RS12275 ENOG41086DT Membrane protein of unknown function HPS44_RS12280 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HPS44_RS12285 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HPS44_RS12300 ENOG4108TFY Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HPS44_RS12315 ENOG4105EJC lysr family transcriptional regulator HPS44_RS12320 ENOG4105EW6 flavin reductase domain protein, FMN-binding HPS44_RS12350 ENOG4108IV0 ABC, transporter HPS44_RS12360 ENOG4105CSH Transporter HPS44_RS12365 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_RS12370 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HPS44_RS12385 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HPS44_RS12395 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPS44_RS12400 ENOG4105D7X high-affinity nickel-transporter HPS44_RS12410 ENOG4105DSE periplasmic solute binding protein HPS44_RS12415 ENOG4105CC5 ABC transporter HPS44_RS12420 ENOG4105DIK (ABC) transporter HPS44_RS12425 ENOG4105MYN Zinc uptake regulation protein HPS44_RS12430 ENOG4105CKI cobalamin synthesis protein HPS44_RS12440 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HPS44_RS12445 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HPS44_RS12455 ENOG4108WBT adenosyltransferase HPS44_RS12460 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HPS44_RS12475 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HPS44_RS12480 ENOG4108Z43 UPF0250 protein HPS44_RS12490 ENOG4105DZ1 carboxypeptidase HPS44_RS12515 ENOG4105CY3 ABC transporter, permease HPS44_RS12525 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HPS44_RS12535 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HPS44_RS12540 ENOG4105D16 lipopolysaccharide heptosyltransferase i HPS44_RS12550 ENOG4105J5G Transferase hexapeptide repeat containing protein HPS44_RS12555 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPS44_RS12565 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPS44_RS12575 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HPS44_RS12595 ENOG4107EF8 Glycosyl transferase (Group 1 HPS44_RS12600 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPS44_RS12605 ENOG4105CAQ asparagine synthetase HPS44_RS12630 ENOG4105CMR udp-glucose 4-epimerase HPS44_RS12635 ENOG4105CMR udp-glucose 4-epimerase HPS44_RS12640 ENOG4105CAQ asparagine synthetase HPS44_RS12660 ENOG4105EY8 ABC transporter HPS44_RS12675 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HPS44_RS12695 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HPS44_RS12715 ENOG4105CAQ asparagine synthetase HPS44_RS12720 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPS44_RS12745 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HPS44_RS12760 ENOG4105DZQ phospholipase D Transphosphatidylase HPS44_RS12765 ENOG4105X23 Endonuclease Exonuclease phosphatase HPS44_RS12770 ENOG4105C9M aspartyl-trna synthetase HPS44_RS12795 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPS44_RS12810 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_RS12815 ENOG4108ZGC gaf domain protein HPS44_RS12820 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_RS12845 ENOG4108KWP DNA-binding transcriptional regulator GlcC HPS44_RS12850 ENOG4107QP3 malate synthase g HPS44_RS12880 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HPS44_RS12890 ENOG4107RDB Major Facilitator HPS44_RS12895 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPS44_RS12900 ENOG4108RXX maleylacetoacetate isomerase HPS44_RS12905 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HPS44_RS12910 ENOG4105D49 3-dehydroquinate synthase HPS44_RS12915 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HPS44_RS12920 ENOG4108JQC penicillin-binding protein 1A HPS44_RS12925 ENOG4105XQ6 frataxin-like protein HPS44_RS12935 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HPS44_RS12945 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HPS44_RS12955 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HPS44_RS12960 ENOG4105D52 delta-aminolevulinic acid dehydratase HPS44_RS12970 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HPS44_RS12975 ENOG4105VF7 tolerance protein HPS44_RS12985 ENOG4108ZT0 50S ribosomal protein l17 HPS44_RS12990 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPS44_RS12995 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HPS44_RS13000 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HPS44_RS13005 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HPS44_RS13015 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HPS44_RS13020 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPS44_RS13025 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HPS44_RS13030 ENOG4105VPB 50S ribosomal protein L30 HPS44_RS13035 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HPS44_RS13040 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HPS44_RS13045 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HPS44_RS13050 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HPS44_RS13055 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HPS44_RS13060 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HPS44_RS13065 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HPS44_RS13070 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HPS44_RS13085 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPS44_RS13100 ENOG4107RST alpha/beta hydrolase fold HPS44_RS13110 ENOG4105C0Z ABC transporter HPS44_RS13115 ENOG4105CDA abc transporter atp-binding protein HPS44_RS13120 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_RS13135 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HPS44_RS13140 ENOG41084PQ 50s ribosomal protein l29 HPS44_RS13145 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HPS44_RS13150 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HPS44_RS13155 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HPS44_RS13160 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HPS44_RS13165 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HPS44_RS13170 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HPS44_RS13180 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HPS44_RS13185 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HPS44_RS13190 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HPS44_RS13195 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HPS44_RS13200 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HPS44_RS13205 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HPS44_RS13210 ENOG4107EXC regulatoR HPS44_RS13225 ENOG4105BZU Histidine kinase HPS44_RS13240 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPS44_RS13245 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HPS44_RS13250 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HPS44_RS13255 ENOG4108VZM 50s ribosomal protein L10 HPS44_RS13260 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HPS44_RS13265 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HPS44_RS13275 ENOG410683Z Preprotein translocase SecE subunit HPS44_RS13285 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HPS44_RS13325 ENOG4107QKW extracellular solute-binding protein family 1 HPS44_RS13330 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS13365 ENOG4107NQ8 LysR family Transcriptional regulator HPS44_RS13370 ENOG4105HDK L-asparaginase HPS44_RS13375 ENOG4105FA0 parb-like partition protein HPS44_RS13385 ENOG4107QJE Chromosome Partitioning Protein HPS44_RS13390 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HPS44_RS13395 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HPS44_RS13400 ENOG4105VEQ Cold shock protein HPS44_RS13405 ENOG4108KK1 membrane protein AbrB duplication HPS44_RS13410 ENOG4105CHM Aminotransferase HPS44_RS13450 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HPS44_RS13465 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS13470 ENOG4105C3U ABC transporter HPS44_RS13475 ENOG4108JQ7 (ABC) transporter HPS44_RS13480 ENOG4105CH2 amidohydrolase HPS44_RS13495 ENOG4105C6T cysteine synthase HPS44_RS13500 ENOG4105CH6 catalase HPS44_RS13510 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HPS44_RS13520 ENOG4105VG0 50S ribosomal protein l34 HPS44_RS13525 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HPS44_RS13530 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPS44_RS13535 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPS44_RS13540 ENOG4105CC0 LysR family Transcriptional regulator HPS44_RS13555 ENOG4105C2I pirin domain protein HPS44_RS13565 ENOG4105EFZ amidohydrolase HPS44_RS13575 ENOG4105RQF LysR family Transcriptional regulator HPS44_RS13580 ENOG4107RP9 extracellular solute-binding protein, family 3 HPS44_RS13585 ENOG4105EAD ABC transporter HPS44_RS13590 ENOG4105DRP amino acid AbC transporter HPS44_RS13595 ENOG4105CDA abc transporter atp-binding protein HPS44_RS13605 ENOG4108594 Permease of the drug metabolite transporter HPS44_RS13635 ENOG4105F38 ABC transporter, permease HPS44_RS13640 ENOG4105D38 putrescine abc transporter HPS44_RS13665 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HPS44_RS13695 ENOG4105CMD Transcriptional regulator, GntR family HPS44_RS13705 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS13710 ENOG4105F38 ABC transporter, permease HPS44_RS13715 ENOG4105D38 putrescine abc transporter HPS44_RS13740 ENOG4105M4H endoribonuclease L-psp HPS44_RS13780 ENOG4105DZC cytosine deaminase HPS44_RS13790 ENOG4105UIB (ABC) transporter HPS44_RS13795 ENOG4108JQ9 ABC transporter HPS44_RS13800 ENOG4107TFB basic membrane HPS44_RS13810 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HPS44_RS13825 ENOG4108MEJ flavin reductase domain protein HPS44_RS13840 ENOG4105F9N Major Facilitator Superfamily HPS44_RS13855 ENOG4105FFC UPF0187 protein HPS44_RS13860 ENOG4108YXU transcriptional regulator AsnC family HPS44_RS13865 ENOG4105C7K acetolactate synthase HPS44_RS13870 ENOG4105CHR reductase HPS44_RS13875 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HPS44_RS13890 ENOG4105C9U ATP-dependent DNA helicase RecQ HPS44_RS13900 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HPS44_RS13905 ENOG4108RPN Protein smg homolog HPS44_RS13915 ENOG4105H1G trap transporter solute receptor taxi family HPS44_RS13935 ENOG4105E5Q amino acid AbC transporter HPS44_RS13940 ENOG4105E5Q amino acid AbC transporter HPS44_RS13945 ENOG4106TNF Periplasmic binding protein HPS44_RS13950 ENOG4105KWI UPF0339 protein HPS44_RS13960 ENOG4105C8Y Acetylornithine aminotransferase HPS44_RS14005 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HPS44_RS14035 ENOG4108NIW Leucine export protein LeuE HPS44_RS14060 ENOG4105JXH GntR family transcriptional regulator HPS44_RS14065 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_RS14080 ENOG4108SF5 RNA Polymerase HPS44_RS14085 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS14100 ENOG4105CHR reductase HPS44_RS14130 ENOG4105E8G Major facilitator Superfamily HPS44_RS14145 ENOG4108WFR AraC Family Transcriptional Regulator HPS44_RS14165 ENOG4107QX3 carboxylase HPS44_RS14170 ENOG4105CHU acetyl-coa acetyltransferase HPS44_RS14175 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HPS44_RS14180 ENOG4105C1G acyl-Coa dehydrogenase HPS44_RS14185 ENOG4105CH2 amidohydrolase HPS44_RS14195 ENOG4105KK4 UPF0060 membrane protein HPS44_RS14210 ENOG410829K Lysine exporter protein (Lyse ygga) HPS44_RS14225 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HPS44_RS14245 ENOG4108Z33 Thiol disulfide Interchange Protein HPS44_RS14255 ENOG4105C75 arginyL-tRNA synthetase HPS44_RS14270 ENOG4105DRS transport system, permease HPS44_RS14275 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HPS44_RS14280 ENOG4105BZ7 extracellular solute-binding protein family 1 HPS44_RS14285 ENOG4108IJ9 (ABC) transporter HPS44_RS14290 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HPS44_RS14295 ENOG4105ETE Transcriptional regulator (LacI family HPS44_RS14305 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HPS44_RS14320 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPS44_RS14350 ENOG4108UQY Iron-storage protein HPS44_RS14360 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HPS44_RS14365 ENOG410829K Lysine exporter protein (Lyse ygga) HPS44_RS14370 ENOG4105C1J atp-dependent rna helicase HPS44_RS14375 ENOG4106J39 exported protein HPS44_RS14380 ENOG4106J39 exported protein HPS44_RS14385 ENOG4105CI2 imidazolone-5-propionate hydrolase HPS44_RS14395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS14400 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_RS14405 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_RS14410 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HPS44_RS14415 ENOG4105KD1 integral membrane protein HPS44_RS14420 ENOG4105UEI Transcriptional Regulator AraC Family HPS44_RS14430 ENOG4107QI6 Cysteine desulfurase HPS44_RS14440 ENOG4105ETT transcriptional Regulator, LysR family HPS44_RS14455 ENOG4105C6Z Gluconate HPS44_RS14470 ENOG4105KB2 stringent starvation protein b HPS44_RS14475 ENOG4107MKT Stringent starvation protein a HPS44_RS14480 ENOG4105EIX cytochrome c1 HPS44_RS14485 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HPS44_RS14490 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HPS44_RS14495 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HPS44_RS14500 ENOG4107QNR UPF0135 protein HPS44_RS14505 ENOG4105C0H protease HPS44_RS14520 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HPS44_RS14525 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HPS44_RS14530 ENOG4107YU2 histidine triad (hIT) protein HPS44_RS14535 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase HPS44_RS14545 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HPS44_RS14550 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HPS44_RS14555 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HPS44_RS14560 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HPS44_RS14565 ENOG4105CIH Imidazole acetol-phosphate transaminase HPS44_RS14570 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HPS44_RS14575 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HPS44_RS14580 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HPS44_RS14590 ENOG4105E3A (ABC) transporter HPS44_RS14595 ENOG4105DA5 (ABC) transporter HPS44_RS14605 ENOG410903C (LipO)protein HPS44_RS14610 ENOG4107PE3 Mammalian cell entry related domain protein HPS44_RS14615 ENOG4105CY3 ABC transporter, permease HPS44_RS14620 ENOG4105DHJ ABC, transporter HPS44_RS14625 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_RS14635 ENOG4105CBP Major Facilitator HPS44_RS14640 ENOG4105EGI Transcriptional regulator HPS44_RS14645 ENOG4105EIF outer membrane protein W HPS44_RS14650 ENOG4105DND Transcriptional regulator HPS44_RS14655 ENOG4105E7W lamb ycsf family protein HPS44_RS14660 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HPS44_RS14665 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPS44_RS14710 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPS44_RS14715 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HPS44_RS14730 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HPS44_RS14735 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPS44_RS14745 ENOG4107QS1 Cytochrome C Oxidase, Subunit III HPS44_RS14765 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HPS44_RS14795 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HPS44_RS14800 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_RS14805 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPS44_RS14810 ENOG4105CG5 Glycosyl transferase (Group 1 HPS44_RS14825 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPS44_RS14840 ENOG4108SUT Major Facilitator Superfamily HPS44_RS14855 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HPS44_RS14865 ENOG4106B0W Curli production assembly transport component CsgG HPS44_RS14875 ENOG4107Y60 (LipO)protein HPS44_RS14880 ENOG4108IYU L-aspartate oxidase HPS44_RS14885 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HPS44_RS14890 ENOG4105EQ0 Major Facilitator superfamily HPS44_RS14895 ENOG4105CR8 Transcriptional regulator HPS44_RS14905 ENOG4107QWB Ornithine cyclodeaminase HPS44_RS14910 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HPS44_RS14915 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HPS44_RS14920 ENOG4105EVZ LysR family transcriptional regulator HPS44_RS14925 ENOG4105CK7 Sodium proline symporter HPS44_RS14930 ENOG4105CYW agmatinase HPS44_RS14935 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HPS44_RS14990 ENOG4105CGH 5'-nucleotidase HPS44_RS15005 ENOG4105CZE histidine utilization repressor HPS44_RS15010 ENOG41090B9 response to stress HPS44_RS15015 ENOG4105CGP Urocanate hydratase HPS44_RS15020 ENOG4105ETS cytosine purines uracil thiamine allantoin HPS44_RS15035 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS15040 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_RS15090 ENOG4105DRR Transcriptional regulator, GntR family HPS44_RS15105 ENOG4105C26 Dehydrogenase HPS44_RS15130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS15140 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_RS15150 ENOG4107T8P acyl-Coa dehydrogenase HPS44_RS15155 ENOG4107T8P acyl-Coa dehydrogenase HPS44_RS15165 ENOG4105D01 (LipO)protein HPS44_RS15170 ENOG4108UZX fmn reductase HPS44_RS15175 ENOG4105GVF (ABC) transporter HPS44_RS15180 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HPS44_RS15185 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HPS44_RS15190 ENOG4107T8P acyl-Coa dehydrogenase HPS44_RS15200 ENOG4108UMI ABC transporter, permease HPS44_RS15205 ENOG4105D01 (LipO)protein HPS44_RS15210 ENOG4105E2Y ABC, transporter HPS44_RS15215 ENOG4105X1Q TOBE domain protein HPS44_RS15220 ENOG4108NST exported protein HPS44_RS15245 ENOG4108S4H thioesterase Superfamily protein HPS44_RS15260 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPS44_RS15265 ENOG4108MG3 formate dehydrogenase HPS44_RS15270 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HPS44_RS15280 ENOG4105EM7 Selenocysteine-specific translation elongation factor HPS44_RS15290 ENOG4105K64 Glycosyl transferase, family 2 HPS44_RS15295 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPS44_RS15300 ENOG4108KS2 transglutaminase domain protein HPS44_RS15305 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HPS44_RS15315 ENOG4105ETT transcriptional Regulator, LysR family HPS44_RS15335 ENOG4105C26 Dehydrogenase HPS44_RS15340 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HPS44_RS15345 ENOG4105DK0 Indole-3-glycerol phosphate synthase HPS44_RS15350 ENOG4108I0Q anthranilate phosphoribosyltransferase HPS44_RS15355 ENOG4105DDQ anthranilate synthase HPS44_RS15365 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPS44_RS15375 ENOG4105NWN ApaG protein HPS44_RS15385 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HPS44_RS15390 ENOG4105T95 Thiol disulfide interChange protein HPS44_RS15400 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HPS44_RS15410 ENOG4105C3M thioredoxin reductase HPS44_RS15415 ENOG4105F2Z 3-oxoadipate enol-lactonase HPS44_RS15430 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS15435 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS15440 ENOG4105C0Z ABC transporter HPS44_RS15445 ENOG4108IV0 ABC, transporter HPS44_RS15450 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) HPS44_RS15465 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HPS44_RS15475 ENOG4105RE0 Asp Glu hydantoin racemase HPS44_RS15480 ENOG4106NZI LysR family Transcriptional regulator HPS44_RS15495 ENOG4107QNJ CoA-transferase subunit B HPS44_RS15510 ENOG4105E39 Enoyl-CoA hydratase HPS44_RS15525 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) HPS44_RS15530 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HPS44_RS15540 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HPS44_RS15545 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HPS44_RS15550 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HPS44_RS15560 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HPS44_RS15570 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HPS44_RS15575 ENOG4105C25 Primosomal protein n' HPS44_RS15580 ENOG4105C4R Atp-dependent dna helicase HPS44_RS15585 ENOG4105E7U AraC family transcriptional regulator HPS44_RS15595 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HPS44_RS15605 ENOG4105ECQ AraC Family Transcriptional Regulator HPS44_RS15610 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HPS44_RS15615 ENOG4105CSR polyphosphate kinase 2 HPS44_RS15620 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HPS44_RS15630 ENOG4108JQ7 (ABC) transporter HPS44_RS15635 ENOG4105C3U ABC transporter HPS44_RS15650 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_RS15655 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HPS44_RS15665 ENOG4105EMY transcriptional regulator HPS44_RS15670 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_RS15680 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HPS44_RS15685 ENOG41060WC Enoyl-CoA hydratase HPS44_RS15690 ENOG4105E39 Enoyl-CoA hydratase HPS44_RS15700 ENOG4105KBX Transcriptional regulator, TetR family HPS44_RS15715 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_RS15730 ENOG4107XZQ multidrug resistance protein HPS44_RS15745 ENOG4108ZHJ Organic hydroperoxide resistance protein HPS44_RS15750 ENOG4105EJC lysr family transcriptional regulator HPS44_RS15760 ENOG4108KPJ rna polymerase sigma factor HPS44_RS15765 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPS44_RS15770 ENOG4108Z9W Outer membrane porin HPS44_RS15785 ENOG4105ERH Fumarylacetoacetate hydrolase HPS44_RS15795 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS15800 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_RS15805 ENOG4105C2J ABC transporter HPS44_RS15810 ENOG4108IV0 ABC, transporter HPS44_RS15820 ENOG4107XBN GntR Family Transcriptional Regulator HPS44_RS15830 ENOG4105DND Transcriptional regulator HPS44_RS15840 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HPS44_RS15850 ENOG4105D9M gamma-glutamylcysteine synthetase HPS44_RS15880 ENOG4105DG4 malate L-lactate dehydrogenase HPS44_RS15885 ENOG4108JQ1 Dehydrogenase HPS44_RS15895 ENOG4105CTX dehydratase HPS44_RS15900 ENOG4105VP7 SAF domain protein HPS44_RS15905 ENOG4105FDP GntR family transcriptional regulator HPS44_RS15910 ENOG4105DWV Homoserine O-trans-acetylase HPS44_RS15915 ENOG4105DWV Homoserine O-trans-acetylase HPS44_RS15920 ENOG4105EYM Major Facilitator superfamily HPS44_RS15930 ENOG4105EN6 Membrane HPS44_RS15935 ENOG4105DRR Transcriptional regulator, GntR family HPS44_RS15950 ENOG4105P4J Allophanate hydrolase, subunit 1 HPS44_RS15960 ENOG4107RSM transcriptional regulator HPS44_RS15980 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_RS15990 ENOG4108JQ1 Dehydrogenase HPS44_RS16005 ENOG4105E3B Multicopper oxidase HPS44_RS16025 ENOG4105BZU Histidine kinase HPS44_RS16030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPS44_RS16035 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HPS44_RS16050 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HPS44_RS16060 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HPS44_RS16065 ENOG4105DFG type I secretion outer membrane protein HPS44_RS16070 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HPS44_RS16075 ENOG4105DWF phosphomethylpyrimidine kinase HPS44_RS16080 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HPS44_RS16085 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HPS44_RS16090 ENOG4105D05 Receptor HPS44_RS16095 ENOG4105C3R Methionine synthase HPS44_RS16100 ENOG4107YCY Transcriptional regulator HPS44_RS16115 ENOG4105CPQ Dehydrogenase HPS44_RS16120 ENOG4105E5Q amino acid AbC transporter HPS44_RS16125 ENOG4105EAD ABC transporter HPS44_RS16130 ENOG4105CDA abc transporter atp-binding protein HPS44_RS16135 ENOG4105CXK mandelate racemase muconate lactonizing HPS44_RS16140 ENOG4105DEI Mannitol dehydrogenase HPS44_RS16160 ENOG4105CEN a g-specific adenine glycosylase HPS44_RS16175 ENOG4105ECQ AraC Family Transcriptional Regulator HPS44_RS16180 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) HPS44_RS16185 ENOG4105CRP Part of the ABC transporter FtsEX involved in HPS44_RS16190 ENOG4105CAK Cell division ATP-binding protein ftsE HPS44_RS16195 ENOG4107QXX ABC transporter HPS44_RS16200 ENOG4105EZ7 amino acid ABC transporter HPS44_RS16205 ENOG4105DRP amino acid AbC transporter HPS44_RS16210 ENOG4105CDA abc transporter atp-binding protein HPS44_RS16230 ENOG4108IV0 ABC, transporter HPS44_RS16235 ENOG4105C2J ABC transporter HPS44_RS16240 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_RS16245 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS16255 ENOG4105MSY salicylate hydroxylase HPS44_RS16260 ENOG4105CBX hi0933 family HPS44_RS16265 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HPS44_RS16270 ENOG4105CQC Prephenate dehydratase HPS44_RS16305 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_RS16315 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HPS44_RS16320 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HPS44_RS16325 ENOG4108Q9V regulatoR HPS44_RS16340 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HPS44_RS16345 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HPS44_RS16350 ENOG4105ENT Efflux transporter rnd family, mfp subunit HPS44_RS16375 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_RS16395 ENOG4105EG2 ABC transporter, permease HPS44_RS16400 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HPS44_RS16405 ENOG4108IJ9 (ABC) transporter HPS44_RS16425 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HPS44_RS16445 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS16450 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_RS16455 ENOG4105C0Z ABC transporter HPS44_RS16460 ENOG4108IV0 ABC, transporter HPS44_RS16480 ENOG4105BZU Histidine kinase HPS44_RS16485 ENOG4105BZU Histidine kinase HPS44_RS16505 ENOG4108UKI Enoyl-CoA hydratase HPS44_RS16545 ENOG4105FUY alpha subunit HPS44_RS16550 ENOG4108SBK dioxygenase, subunit beta HPS44_RS16555 ENOG4105D3W isochorismatase HPS44_RS16560 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HPS44_RS16570 ENOG4105E4C Lytic transglycosylase catalytic HPS44_RS16575 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HPS44_RS16580 ENOG4107RZ7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HPS44_RS16590 ENOG4105VCQ rubredoxin HPS44_RS16595 ENOG4108UJU UPF0301 protein HPS44_RS16600 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HPS44_RS16610 ENOG4105CD3 dihydroorotase HPS44_RS16615 ENOG4108Z20 Acyl-transferase HPS44_RS16630 ENOG4105JSC dimethylmenaquinone methyltransferase HPS44_RS16640 ENOG4106PMH Extracellular solute-binding protein family 3 HPS44_RS16645 ENOG4105E5Q amino acid AbC transporter HPS44_RS16650 ENOG4105DRP amino acid AbC transporter HPS44_RS16655 ENOG4105CDA abc transporter atp-binding protein HPS44_RS16665 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HPS44_RS16675 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HPS44_RS16680 ENOG4105E2X shikimate dehydrogenase HPS44_RS16690 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS16695 ENOG4107Z33 ABC transporter, permease HPS44_RS16705 ENOG4105DHQ Histidine kinase HPS44_RS16720 ENOG4105IPS esterase HPS44_RS16725 ENOG4105DFU Cell wall formation (By similarity) HPS44_RS16730 ENOG4107QX9 Thiol disulfide interChange protein HPS44_RS16735 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HPS44_RS16740 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HPS44_RS16745 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPS44_RS16750 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HPS44_RS16760 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HPS44_RS16785 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPS44_RS16805 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPS44_RS16810 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPS44_RS16820 ENOG4108YXU transcriptional regulator AsnC family HPS44_RS16835 ENOG4105DND Transcriptional regulator HPS44_RS16850 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HPS44_RS16855 ENOG4105CD5 CoA-binding domain protein HPS44_RS16860 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HPS44_RS16865 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HPS44_RS16885 ENOG4105N42 UPF0307 protein HPS44_RS16890 ENOG4105CMS peptidase U62, modulator of DNA gyrase HPS44_RS16895 ENOG4105CH5 extracellular solute-binding protein, family 7 HPS44_RS16905 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS16910 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_RS16915 ENOG4105C0Z ABC transporter HPS44_RS16920 ENOG4108IV0 ABC, transporter HPS44_RS16925 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HPS44_RS16930 ENOG4108UJD 30S ribosomal protein S9 HPS44_RS16935 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HPS44_RS16945 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HPS44_RS16960 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HPS44_RS16970 ENOG4105N14 lysine exporter protein LysE YggA HPS44_RS16975 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HPS44_RS16980 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HPS44_RS16990 ENOG4108RWI nicotinamidase HPS44_RS16995 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPS44_RS17010 ENOG4105CYN Serine protein kinase HPS44_RS17015 ENOG4106AKX UPF0229 protein HPS44_RS17020 ENOG4105ED1 spovr family HPS44_RS17030 ENOG4105ETT transcriptional Regulator, LysR family HPS44_RS17035 ENOG4105MDS 4-oxalocrotonate tautomerase HPS44_RS17045 ENOG4108Z33 Thiol disulfide Interchange Protein HPS44_RS17240 ENOG4105EMN RNA polymerase sigma factor HPS44_RS17265 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPS44_RS17270 ENOG4105JGF anti-sigma regulatory factor serine threonine protein kinase HPS44_RS17275 ENOG41083UI stage II sporulation protein HPS44_RS17290 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPS44_RS17310 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HPS44_RS17315 ENOG4105E9H Lytic Murein transglycosylase HPS44_RS17320 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPS44_RS17325 ENOG4105D1A Methyltransferase HPS44_RS17330 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPS44_RS17340 ENOG4105BZS acriflavin resistance protein HPS44_RS17345 ENOG4107RZZ dna polymerase iii epsilon subunit HPS44_RS17360 ENOG4108UPT UPF0178 protein HPS44_RS17375 ENOG4105D6U Sodium Glutamate Symporter HPS44_RS17390 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HPS44_RS17405 ENOG4105CR8 Transcriptional regulator HPS44_RS17425 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS17435 ENOG4108IV0 ABC, transporter HPS44_RS17440 ENOG4105C0Z ABC transporter HPS44_RS17445 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_RS17455 ENOG4105CMU LysR family (Transcriptional regulator HPS44_RS17460 ENOG4105VAW lrga family HPS44_RS17465 ENOG41067MG lrgb family HPS44_RS17475 ENOG4105T38 integral membrane protein HPS44_RS17480 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_RS17495 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HPS44_RS17505 ENOG4108YXU transcriptional regulator AsnC family HPS44_RS17520 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS17525 ENOG4105EHG Permease protein HPS44_RS17535 ENOG4105KCK Peptidoglycan-associated lipoprotein HPS44_RS17540 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HPS44_RS17555 ENOG4105E02 MotA TolQ exbB proton channel HPS44_RS17560 ENOG4107YD3 Thioesterase HPS44_RS17565 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HPS44_RS17595 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HPS44_RS17600 ENOG4105EXG Transcriptional regulator HPS44_RS17610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPS44_RS17615 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_RS17655 ENOG4105C01 Dihydroxy-acid dehydratase HPS44_RS17660 ENOG4105W2Z cytochrome C, class I HPS44_RS17665 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HPS44_RS17675 ENOG4105EW9 transcriptional regulator AsnC family HPS44_RS17715 ENOG4105ETT transcriptional Regulator, LysR family HPS44_RS17725 ENOG4105CH2 amidohydrolase HPS44_RS17730 ENOG4105EKE dihydroorotase HPS44_RS17735 ENOG4105C5H ABC transporter HPS44_RS17745 ENOG4108V6E Cell division protein mraZ HPS44_RS17750 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HPS44_RS17755 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HPS44_RS17760 ENOG4105CJN penicillin-binding protein HPS44_RS17765 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HPS44_RS17770 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HPS44_RS17775 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HPS44_RS17785 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HPS44_RS17790 ENOG4105DFU Cell wall formation (By similarity) HPS44_RS17795 ENOG4105CPF Cell wall formation (By similarity) HPS44_RS17800 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HPS44_RS17805 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HPS44_RS17810 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HPS44_RS17815 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HPS44_RS17825 ENOG4105DR5 peptidase HPS44_RS17830 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HPS44_RS17850 ENOG4105C7K acetolactate synthase HPS44_RS17865 ENOG4108XM1 transcriptional regulator AsnC family HPS44_RS17880 ENOG4105CJW magnesium transporter HPS44_RS17885 ENOG4105NAU thioesterase Superfamily protein HPS44_RS17890 ENOG4105HMI Membrane HPS44_RS17900 ENOG4105CH2 amidohydrolase HPS44_RS17905 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS17910 ENOG4105ECY inositol monophosphatase HPS44_RS17915 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HPS44_RS17920 ENOG4105CJQ hydrolase, family 31 HPS44_RS17925 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS17930 ENOG4108UMI ABC transporter, permease HPS44_RS17935 ENOG4105D01 (LipO)protein HPS44_RS17960 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HPS44_RS17990 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS17995 ENOG4106P55 Transcriptional regulator HPS44_RS18005 ENOG41090R7 Ferric uptake HPS44_RS18030 ENOG4108R3E Dna-3-methyladenine glycosylase i HPS44_RS18035 ENOG4105E0M Sulfatase HPS44_RS18040 ENOG41066T0 asmA family HPS44_RS18055 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HPS44_RS18085 ENOG4105KZX Pterin carbinolamine dehydratase HPS44_RS18110 ENOG4108S0S Nucleotidyl transferase HPS44_RS18115 ENOG4105EHM Aminoglycoside phosphotransferase HPS44_RS18125 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HPS44_RS18130 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HPS44_RS18135 ENOG4105BZW Glycerate kinase HPS44_RS18140 ENOG4105CA9 Pyruvate kinase HPS44_RS18150 ENOG4107QPN acyl-Coa dehydrogenase HPS44_RS18155 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HPS44_RS18165 ENOG4107THD Involved in phosphonate degradation (By similarity) HPS44_RS18175 ENOG4105E9Q Acyl-transferase HPS44_RS18180 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HPS44_RS18185 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HPS44_RS18190 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HPS44_RS18205 ENOG4107SDU Methyl-accepting chemotaxis HPS44_RS18215 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_RS18225 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HPS44_RS18245 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_RS18255 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS18260 ENOG4105CHU acetyl-coa acetyltransferase HPS44_RS18270 ENOG4105CC9 acyl-Coa dehydrogenase HPS44_RS18275 ENOG4108KC2 acyl-Coa dehydrogenase HPS44_RS18280 ENOG4108UKI Enoyl-CoA hydratase HPS44_RS18290 ENOG4108M9J MaoC like domain protein HPS44_RS18300 ENOG4105CI0 Citrate lyase HPS44_RS18305 ENOG4108MGF sugar kinase HPS44_RS18310 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HPS44_RS18315 ENOG4105DJ0 Poly(A) Polymerase HPS44_RS18325 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HPS44_RS18330 ENOG4105CXB phosphoribosylaminoimidazole synthetase HPS44_RS18340 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HPS44_RS18345 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HPS44_RS18350 ENOG4105DQR SNARE associated Golgi HPS44_RS18360 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HPS44_RS18365 ENOG4105K8N protein family UPF0079, ATPase HPS44_RS18370 ENOG4105C9Q fumarate hydratase class II HPS44_RS18385 ENOG4105DUM transcriptional regulator, lysR family HPS44_RS18390 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_RS18395 ENOG4105CUB amino acid HPS44_RS18400 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_RS18410 ENOG4105CSU acyl-Coa dehydrogenase HPS44_RS18415 ENOG4106NZI LysR family Transcriptional regulator HPS44_RS18420 ENOG4105ERH Fumarylacetoacetate hydrolase HPS44_RS18450 ENOG4105CR8 Transcriptional regulator HPS44_RS18460 ENOG4105D5U fad dependent oxidoreductase HPS44_RS18470 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HPS44_RS18485 ENOG4105DJY efflux transporter, rnd family, mfp subunit HPS44_RS18490 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPS44_RS18495 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_RS18500 ENOG4106NZI LysR family Transcriptional regulator HPS44_RS18515 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPS44_RS18550 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPS44_RS18555 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPS44_RS18565 ENOG4105ENT Efflux transporter rnd family, mfp subunit HPS44_RS18570 ENOG4105CUZ uba thif-type nad fad binding protein HPS44_RS18605 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPS44_RS18615 ENOG4108UHU Aldolase HPS44_RS18630 ENOG4105K64 Glycosyl transferase, family 2 HPS44_RS18635 ENOG4108IV0 ABC, transporter HPS44_RS18640 ENOG4105C0Z ABC transporter HPS44_RS18655 ENOG4105CHR reductase HPS44_RS18660 ENOG4106IPI cyclase, family HPS44_RS18675 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS18680 ENOG4108UKV benzoate 1,2-dioxygenase HPS44_RS18685 ENOG4105FUY alpha subunit HPS44_RS18710 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_RS18715 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_RS18720 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS18725 ENOG4105C3U ABC transporter HPS44_RS18730 ENOG4108JQ7 (ABC) transporter HPS44_RS18750 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HPS44_RS18755 ENOG4105C5H ABC transporter HPS44_RS18780 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HPS44_RS18785 ENOG4107QMS site-determining protein HPS44_RS18790 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HPS44_RS18795 ENOG4105CX6 glutaminyL-tRNA synthetase HPS44_RS18805 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPS44_RS18810 ENOG4105C9U ATP-dependent DNA helicase RecQ HPS44_RS18830 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HPS44_RS18840 ENOG4105ECP epimerase HPS44_RS18845 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HPS44_RS18850 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HPS44_RS18865 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPS44_RS18870 ENOG4105D0A hydroxylase HPS44_RS18880 ENOG4107RAQ aminopeptidase HPS44_RS18895 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HPS44_RS18900 ENOG4108Z9W Outer membrane porin HPS44_RS18915 ENOG4105ERG peptidase m48, ste24p HPS44_RS18935 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPS44_RS18955 ENOG4105EYM Major Facilitator superfamily HPS44_RS18960 ENOG4107ZSV Receptor HPS44_RS18970 ENOG4105C1J atp-dependent rna helicase HPS44_RS18985 ENOG4107TH8 cina domain protein HPS44_RS18990 ENOG41069M3 Transcriptional regulator HPS44_RS19005 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HPS44_RS19010 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate HPS44_RS19015 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HPS44_RS19105 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPS44_RS19110 ENOG41090R7 Ferric uptake HPS44_RS19115 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HPS44_RS19125 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HPS44_RS19130 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HPS44_RS19140 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HPS44_RS19150 ENOG4105CFG Acts as a chaperone (By similarity) HPS44_RS19155 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HPS44_RS19170 ENOG4108YYQ gCN5-related N-acetyltransferase HPS44_RS19190 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPS44_RS19225 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS19230 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_RS19245 ENOG4105EEX Two component transcriptional regulator (Winged helix family HPS44_RS19250 ENOG4105C08 Histidine kinase HPS44_RS19255 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HPS44_RS19260 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HPS44_RS19265 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HPS44_RS19280 ENOG4107QN1 sodium solute HPS44_RS19290 ENOG4105C98 muts2 protein HPS44_RS19295 ENOG4105C3M thioredoxin reductase HPS44_RS19300 ENOG4105CNU cell division protein FtsK HPS44_RS19305 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HPS44_RS19310 ENOG4105KME endoribonuclease L-psp HPS44_RS19320 ENOG4105C2X Arabinose 5-phosphate isomerase HPS44_RS19360 ENOG4105D1H recombination factor protein RarA HPS44_RS19365 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HPS44_RS19405 ENOG4105DIA mandelate racemase muconate lactonizing HPS44_RS19410 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_RS19430 ENOG4108IPW abc transporter atp-binding protein HPS44_RS19470 ENOG4105DTD Dehydrogenase HPS44_RS19475 ENOG4105D1Q UPF0246 protein HPS44_RS19485 ENOG4105C7K acetolactate synthase HPS44_RS19490 ENOG4108ZP8 Acetolactate synthase small subunit HPS44_RS19495 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HPS44_RS19500 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HPS44_RS19510 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HPS44_RS19515 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HPS44_RS19525 ENOG4105C7B Threonine dehydratase HPS44_RS19535 ENOG4105ES4 Nitrilase HPS44_RS19545 ENOG4105E7U AraC family transcriptional regulator HPS44_RS19570 ENOG4105CP7 Triose-phosphate isomerase HPS44_RS19575 ENOG4105NTZ Preprotein translocase subunit SecG HPS44_RS19615 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS19635 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HPS44_RS19655 ENOG4108SF5 RNA Polymerase HPS44_RS19660 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_RS19675 ENOG4108SF5 RNA Polymerase HPS44_RS19695 ENOG4105ECM Sensor protein basS pmrB HPS44_RS19705 ENOG4105D4T Citrate transporter HPS44_RS19710 ENOG4105CHR reductase HPS44_RS19730 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPS44_RS19735 ENOG4105CQZ Histidine kinase HPS44_RS19755 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HPS44_RS19760 ENOG4105XDF Protein of unknown function (DUF1272) HPS44_RS19765 ENOG4105CKW Inner membrane protein yedI HPS44_RS19770 ENOG4105GAV receptor HPS44_RS19795 ENOG4108JQ6 ABC transporter HPS44_RS19805 ENOG4106R87 Extracellular solute-binding protein, family 5 HPS44_RS19825 ENOG4105BZS acriflavin resistance protein HPS44_RS19840 ENOG4105C94 Transporter HPS44_RS19845 ENOG4105ENT Efflux transporter rnd family, mfp subunit HPS44_RS19850 ENOG4105BZS acriflavin resistance protein HPS44_RS19865 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_RS19870 ENOG4105BZS acriflavin resistance protein HPS44_RS19875 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPS44_RS19880 ENOG4108IG5 Transcriptional regulator HPS44_RS19885 ENOG4108R4R Iron-regulated virulence regulatory protein HPS44_RS19905 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HPS44_RS19930 ENOG4108Z9W Outer membrane porin HPS44_RS19935 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HPS44_RS19940 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPS44_RS19945 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HPS44_RS19950 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPS44_RS19965 ENOG4108IEH NADH dehydrogenase subunit g HPS44_RS19970 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HPS44_RS19975 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPS44_RS19980 ENOG4105DF2 NADH dehydrogenase subunit j HPS44_RS19985 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPS44_RS19995 ENOG4105C8S subunit m HPS44_RS20000 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPS44_RS20010 ENOG4108ESX Receptor HPS44_RS20015 ENOG4105EAC phosphoserine phosphatase HPS44_RS20020 ENOG4108JA2 transcriptioN-repair coupling factor HPS44_RS20025 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HPS44_RS20030 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HPS44_RS20040 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPS44_RS20045 ENOG4105D3R alkyl hydroperoxide reductase HPS44_RS20050 ENOG4105E0F Histidine kinase HPS44_RS20060 ENOG41072GX Peptidase M22 Glycoprotease HPS44_RS20065 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HPS44_RS20070 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) HPS44_RS20075 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HPS44_RS20085 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HPS44_RS20090 ENOG4107TF3 peptidylprolyl cis-trans isomerase HPS44_RS20100 ENOG4107835 probably involved in intracellular septation (By similarity) HPS44_RS20105 ENOG4105E0X reductase HPS44_RS20110 ENOG4108JJB ABC transporter HPS44_RS20115 ENOG4107QCX Transporter HPS44_RS20120 ENOG4107ZYJ bioY protein HPS44_RS20135 ENOG4105C0Z ABC transporter HPS44_RS20140 ENOG4108IV0 ABC, transporter HPS44_RS20150 ENOG4105HSS phospholipase C HPS44_RS20170 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS20180 ENOG4108IV0 ABC, transporter HPS44_RS20185 ENOG4105C0Z ABC transporter HPS44_RS20190 ENOG4105CSM endonuclease III HPS44_RS20195 ENOG4108R3D Electron transport complex HPS44_RS20205 ENOG4105DP0 ferredoxin-NADP reductase HPS44_RS20210 ENOG4108Z4U Ferredoxin HPS44_RS20215 ENOG4107RH7 Nicotinate phosphoribosyltransferase HPS44_RS20220 ENOG4105M4H endoribonuclease L-psp HPS44_RS20230 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HPS44_RS20235 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPS44_RS20240 ENOG4105CSH Transporter HPS44_RS20245 ENOG4105CWC Acetylornithine deacetylase HPS44_RS20255 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HPS44_RS20260 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HPS44_RS20265 ENOG41061N2 exported protein HPS44_RS20270 ENOG4107QQB Ribonuclease E HPS44_RS20275 ENOG4105EI2 Pseudouridine synthase HPS44_RS20280 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPS44_RS20285 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HPS44_RS20290 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HPS44_RS20300 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HPS44_RS20305 ENOG4108UHJ MAF-like protein HPS44_RS20310 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HPS44_RS20315 ENOG4105VGS 50s ribosomal protein l32 HPS44_RS20325 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPS44_RS20330 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HPS44_RS20335 ENOG4105CHR reductase HPS44_RS20340 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPS44_RS20345 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPS44_RS20355 ENOG4105EMN RNA polymerase sigma factor HPS44_RS20370 ENOG4105C0H protease HPS44_RS20375 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HPS44_RS20380 ENOG4105C3F Signal peptidase i HPS44_RS20385 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HPS44_RS20390 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HPS44_RS20395 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HPS44_RS20445 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HPS44_RS20455 ENOG4108MP6 LysR family Transcriptional regulator HPS44_RS20465 ENOG4105C26 Dehydrogenase HPS44_RS20470 ENOG4107R11 Transcriptional regulator HPS44_RS20480 ENOG4105K4H Nlp p60 protein HPS44_RS20485 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPS44_RS20490 ENOG4108ZJF Glcg protein HPS44_RS20505 ENOG4108Q5Y Membrane HPS44_RS20510 ENOG4105C5W Aldolase HPS44_RS20515 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPS44_RS20540 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPS44_RS20560 ENOG4107YB6 acetyltransferase, (GNAT) family HPS44_RS20570 ENOG4105D44 asparaginase HPS44_RS20575 ENOG4108JQ6 ABC transporter HPS44_RS20580 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_RS20615 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HPS44_RS20625 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HPS44_RS20640 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HPS44_RS20650 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPS44_RS20680 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HPS44_RS20685 ENOG4108YXA Membrane HPS44_RS20690 ENOG4105DXD 2-methylcitrate dehydratase HPS44_RS20695 ENOG4105BZN citrate synthase HPS44_RS20700 ENOG4105CR4 methylisocitrate lyase HPS44_RS20705 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HPS44_RS20710 ENOG4105FDP GntR family transcriptional regulator HPS44_RS20715 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HPS44_RS20720 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HPS44_RS20730 ENOG4105E33 succinate dehydrogenase HPS44_RS20735 ENOG41060IS Flavinator of succinate dehydrogenase HPS44_RS20740 ENOG4105BZN citrate synthase HPS44_RS20755 ENOG4105C6K Malic enzyme HPS44_RS20760 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HPS44_RS20765 ENOG4105EPD Oligopeptide transporter, Opt family HPS44_RS20770 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HPS44_RS20785 ENOG4105K6H D-cysteine desulfhydrase HPS44_RS20790 ENOG4108XM1 transcriptional regulator AsnC family HPS44_RS20795 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HPS44_RS20800 ENOG4105C7S Dehydrogenase HPS44_RS20805 ENOG4107QN2 dihydrolipoyl dehydrogenase HPS44_RS20810 ENOG4105D6Z AFG1 family ATPase HPS44_RS20815 ENOG4108SF5 RNA Polymerase HPS44_RS20820 ENOG4108S3W Anti-feci sigma factor, fecr HPS44_RS20825 ENOG4105E0K tonB-dependent siderophore receptor HPS44_RS20860 ENOG4105BZM domain protein HPS44_RS20865 ENOG4105DVT helicase HPS44_RS20870 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HPS44_RS20875 ENOG4105C34 Pseudouridine synthase HPS44_RS20880 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HPS44_RS20885 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class HPS44_RS20890 ENOG4105CHR reductase HPS44_RS20895 ENOG4108NVM synthesis repressor PhaR HPS44_RS20920 ENOG4105D5K Hemolysin activator protein HPS44_RS20945 ENOG4105JAB phenazine biosynthesis protein, phzf family HPS44_RS20950 ENOG4105K3G Periplasmic Protein HPS44_RS20960 ENOG4105VDW Csbd family HPS44_RS20975 ENOG4105BZ1 (ABC) transporter HPS44_RS20990 ENOG4105ED9 Protein of unknown function (DUF455) HPS44_RS20995 ENOG4108RPX mosc domain containing protein HPS44_RS21000 ENOG4105CVE Lytic murein transglycosylase HPS44_RS21015 ENOG4105C1G acyl-Coa dehydrogenase HPS44_RS21025 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HPS44_RS21035 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HPS44_RS21045 ENOG4108XTA Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate HPS44_RS21055 ENOG410802X bacteriophage n4 adsorption protein b HPS44_RS21065 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPS44_RS21080 ENOG4105F27 Major Facilitator HPS44_RS21085 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPS44_RS21090 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HPS44_RS21095 ENOG4105UYK outer membrane protein a HPS44_RS21100 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPS44_RS21105 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HPS44_RS21110 ENOG4105CQC Prephenate dehydratase HPS44_RS21115 ENOG4105CIH Imidazole acetol-phosphate transaminase HPS44_RS21125 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HPS44_RS21130 ENOG4105CAT Cytidine monophosphate kinase HPS44_RS21135 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HPS44_RS21150 ENOG4105CFV Tetratricopeptide repeat protein HPS44_RS21155 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HPS44_RS21160 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HPS44_RS21170 ENOG4105C6T cysteine synthase HPS44_RS21190 ENOG4105CVE Lytic murein transglycosylase HPS44_RS21200 ENOG4105BZJ Electron transfer flavoprotein HPS44_RS21205 ENOG4105C10 Electron transfer flavoprotein HPS44_RS21225 ENOG4105CSU acyl-Coa dehydrogenase HPS44_RS21230 ENOG4105D3R alkyl hydroperoxide reductase HPS44_RS21235 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HPS44_RS21240 ENOG4108I5D sulfate abc transporter HPS44_RS21265 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HPS44_RS21285 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HPS44_RS21290 ENOG4105P8F nudix hydrolase HPS44_RS21295 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HPS44_RS21300 ENOG4105D0M Protease HtpX homolog HPS44_RS21305 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HPS44_RS21315 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HPS44_RS21320 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HPS44_RS21325 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HPS44_RS21330 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HPS44_RS21335 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HPS44_RS21340 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HPS44_RS21345 ENOG4105C26 Dehydrogenase HPS44_RS21350 ENOG4108UKI Enoyl-CoA hydratase HPS44_RS21355 ENOG4108ZJI phenylacetic acid degradation protein HPS44_RS21365 ENOG4107QI1 Mate efflux family protein HPS44_RS21380 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HPS44_RS21385 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HPS44_RS21390 ENOG4105W5Q DNA repair protein (RadC HPS44_RS21400 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HPS44_RS21405 ENOG4108RXX maleylacetoacetate isomerase HPS44_RS21410 ENOG4105C0H protease HPS44_RS21415 ENOG4105DHQ Histidine kinase HPS44_RS21420 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_RS21435 ENOG4105CKI cobalamin synthesis protein HPS44_RS21440 ENOG4105CKI cobalamin synthesis protein HPS44_RS21445 ENOG4105EJC lysr family transcriptional regulator HPS44_RS21460 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HPS44_RS21465 ENOG4105FE9 pseudouridine synthase HPS44_RS21470 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HPS44_RS21475 ENOG4105CHV Transcription elongation factor NusA HPS44_RS21480 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HPS44_RS21485 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HPS44_RS21490 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HPS44_RS21495 ENOG4105CI3 gtp-binding protein typa HPS44_RS21520 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HPS44_RS21525 ENOG4108URH decarboxylase HPS44_RS21530 ENOG4105C2M dna polymerase I HPS44_RS21540 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HPS44_RS21545 ENOG4105EAM Na Pi-cotransporter HPS44_RS21550 ENOG4105EJQ L-serine dehydratase HPS44_RS21555 ENOG4105D0M Protease HtpX homolog HPS44_RS21565 ENOG4105KHC sulfurtransferase HPS44_RS21575 ENOG4105DUM transcriptional regulator, lysR family HPS44_RS21580 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS21590 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HPS44_RS21625 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HPS44_RS21630 ENOG4105CTB Polyprenyl synthetase HPS44_RS21640 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) HPS44_RS21645 ENOG4105NX3 Membrane HPS44_RS21650 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HPS44_RS21660 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HPS44_RS21665 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HPS44_RS21675 ENOG4105CDU Replicative dna helicase HPS44_RS21680 ENOG4105DHU Bile acid HPS44_RS21685 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HPS44_RS21695 ENOG4105EW9 transcriptional regulator AsnC family HPS44_RS21720 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_RS21770 ENOG4105CXT aspartate transcarbamylase HPS44_RS21790 ENOG4105CSH Transporter HPS44_RS21795 ENOG4105DHQ Histidine kinase HPS44_RS21805 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HPS44_RS21810 ENOG4108004 Modulates RecA activity (By similarity) HPS44_RS21815 ENOG4105DZ2 Transcriptional regulator HPS44_RS21835 ENOG4105CMV Succinyl-CoA synthetase subunit beta HPS44_RS21840 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HPS44_RS21845 ENOG4108ZCF integral membrane protein HPS44_RS21850 ENOG4108ZCF integral membrane protein HPS44_RS21855 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HPS44_RS21875 ENOG4105F0N pyrophosphate phospho-hydrolase HPS44_RS21905 ENOG4105C0Z ABC transporter HPS44_RS21910 ENOG4108IV0 ABC, transporter HPS44_RS21915 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS21935 ENOG4108IAB Phoh family HPS44_RS21940 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPS44_RS21950 ENOG4105CHM Aminotransferase HPS44_RS21955 ENOG4105D6E homoserine dehydrogenase HPS44_RS21970 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HPS44_RS21975 ENOG4105CD8 aminopeptidase N HPS44_RS21985 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HPS44_RS21990 ENOG4105D1U peptidase U62 modulator of DNA gyrase HPS44_RS21995 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPS44_RS22000 ENOG4105CQB FAD linked oxidase domain protein HPS44_RS22005 ENOG4105CQB FAD linked oxidase domain protein HPS44_RS22010 ENOG4105EU8 FAD linked oxidase domain protein HPS44_RS22015 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPS44_RS22020 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPS44_RS22025 ENOG4105W8H transhydrogenase (subunit alpha HPS44_RS22030 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPS44_RS22045 ENOG4105ETT transcriptional Regulator, LysR family HPS44_RS22050 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HPS44_RS22055 ENOG4105HF0 Membrane HPS44_RS22060 ENOG4108U78 Glutathione S-transferase HPS44_RS22065 ENOG4107QTF adenylosuccinate lyase HPS44_RS22070 ENOG4105T86 cytochrome C HPS44_RS22100 ENOG4108REF Sporulation integral membrane protein ytvi HPS44_RS22110 ENOG4108MAJ Membrane HPS44_RS22190 ENOG4105UZW Tail fiber assembly protein HPS44_RS22210 ENOG4105BZU Histidine kinase HPS44_RS22220 ENOG4105RPH Inner membrane protein YddG HPS44_RS22255 ENOG41067HS methyltransferase HPS44_RS22265 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HPS44_RS22270 ENOG4105CBC glutamate synthase HPS44_RS22280 ENOG41066VF YeeE YedE family protein HPS44_RS22285 ENOG4105RK9 auxin efflux carrier HPS44_RS22295 ENOG4108HPG -acetyltransferase HPS44_RS22315 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HPS44_RS22320 ENOG4105C2N RNA methyltransferase TrmH family group 3 HPS44_RS22325 ENOG4105C28 cystathionine HPS44_RS22330 ENOG4107E2E PKHD-type hydroxylase HPS44_RS22335 ENOG4105K70 DNA-binding protein HPS44_RS22360 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPS44_RS22365 ENOG4105DHQ Histidine kinase HPS44_RS22370 ENOG4105DFH Transport of potassium into the cell (By similarity) HPS44_RS22380 ENOG4105CDH Citrulline--aspartate ligase HPS44_RS22385 ENOG4105C5Q Transcriptional regulator HPS44_RS22390 ENOG4105GAK amidohydrolase 2 HPS44_RS22410 ENOG4108XEP Alpha Beta Hydrolase Fold protein HPS44_RS22415 ENOG4105DBV ornithine carbamoyltransferase HPS44_RS22420 ENOG4105C8Y Acetylornithine aminotransferase HPS44_RS22430 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_RS22440 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_RS22445 ENOG4105CV6 ABC transporter, permease HPS44_RS22455 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) HPS44_RS22465 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS22470 ENOG4105F38 ABC transporter, permease HPS44_RS22475 ENOG4105D38 putrescine abc transporter HPS44_RS22485 ENOG4108RB4 3-methyladenine DNA glycosylase HPS44_RS22495 ENOG4107QSV RmuC domain protein HPS44_RS22505 ENOG4105CSU acyl-Coa dehydrogenase HPS44_RS22515 ENOG4108UTW Plays a role in the regulation of phosphate uptake HPS44_RS22520 ENOG4105HSS phospholipase C HPS44_RS22525 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HPS44_RS22530 ENOG4108EKC n-acetylglutamate synthase HPS44_RS22535 ENOG4105CQ7 ATP-dependent helicase HPS44_RS22540 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HPS44_RS22555 ENOG4105C0B DNA polymerase III (alpha subunit) HPS44_RS22560 ENOG4105CPK Glycosyl transferase (Group 1 HPS44_RS22565 ENOG4107BJW polysaccharide deacetylase HPS44_RS22570 ENOG4106WTF Glycosyl transferase, family 2 HPS44_RS22575 ENOG4107T8Q Glycosyl transferase (Group 1 HPS44_RS22580 ENOG4107BJW polysaccharide deacetylase HPS44_RS22590 ENOG4105KRS Proteinase inhibitor HPS44_RS22605 ENOG4105BZ1 (ABC) transporter HPS44_RS22610 ENOG4105CKD glutathione-regulated potassium-efflux system protein HPS44_RS22625 ENOG4106JH6 (LipO)protein HPS44_RS22630 ENOG4105C03 ribonuclease HPS44_RS22660 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_RS22670 ENOG4105CK2 sodium dicarboxylate symporter HPS44_RS22680 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HPS44_RS22685 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HPS44_RS22690 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HPS44_RS22700 ENOG4105C12 Phosphoribosylglycinamide synthetase HPS44_RS22705 ENOG4105CDY transcriptional regulatory protein HPS44_RS22710 ENOG4105D7A ATP-binding protein HPS44_RS22715 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HPS44_RS22725 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPS44_RS22730 ENOG4105CW7 secretion protein, HlyD family HPS44_RS22735 ENOG4105ETP RND efflux system, outer membrane lipoprotein HPS44_RS22740 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HPS44_RS22755 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPS44_RS22800 ENOG4105WPN DNA integration recombination invertion protein HPS44_RS22805 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HPS44_RS22815 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HPS44_RS22820 ENOG4105K63 Thioredoxin HPS44_RS22825 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPS44_RS22835 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPS44_RS22840 ENOG4107Z3H Transcriptional regulator, TetR family HPS44_RS22850 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPS44_RS22875 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HPS44_RS22880 ENOG4105EV8 ectoine hydroxylase HPS44_RS22885 ENOG4105QVC MOSC domain-containing protein HPS44_RS22890 ENOG4105KPY Small multidrug resistance protein HPS44_RS22905 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_RS22920 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HPS44_RS22925 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HPS44_RS22935 ENOG4105K5M 30s ribosomal protein S16 HPS44_RS22945 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HPS44_RS22950 ENOG4105WBV Transcriptional regulator HPS44_RS22955 ENOG4106TNF Periplasmic binding protein HPS44_RS22960 ENOG4105E5Q amino acid AbC transporter HPS44_RS22965 ENOG4105CDA abc transporter atp-binding protein HPS44_RS22970 ENOG4105CJP fad dependent oxidoreductase HPS44_RS22975 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HPS44_RS22980 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HPS44_RS22985 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HPS44_RS23005 ENOG4105N21 Membrane HPS44_RS23010 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPS44_RS23015 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HPS44_RS23020 ENOG4105CIH Imidazole acetol-phosphate transaminase HPS44_RS23025 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HPS44_RS23030 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPS44_RS23035 ENOG4107QJR hflk protein HPS44_RS23040 ENOG4105EPW hflc protein HPS44_RS23045 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HPS44_RS23050 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HPS44_RS23055 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HPS44_RS23060 ENOG4105VCC 30S ribosomal protein S21 HPS44_RS23070 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPS44_RS23080 ENOG4105CPK Glycosyl transferase (Group 1 HPS44_RS23150 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPS44_RS23160 ENOG4107S2Z UPF0761 membrane protein HPS44_RS23170 ENOG4105CNG UPF0061 protein HPS44_RS23190 ENOG4105BZU Histidine kinase HPS44_RS23195 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HPS44_RS23200 ENOG4105ERG peptidase m48, ste24p HPS44_RS23295 ENOG4108JJA ABC, transporter HPS44_RS23305 ENOG4105DFG type I secretion outer membrane protein HPS44_RS23325 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPS44_RS23335 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HPS44_RS23340 ENOG4105CH5 extracellular solute-binding protein, family 7 HPS44_RS23365 ENOG4105CPT Alpha beta hydrolase HPS44_RS23400 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_RS23405 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_RS23410 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HPS44_RS23415 ENOG4105DIQ Transcriptional regulator HPS44_RS23420 ENOG4105FR1 rard protein HPS44_RS23430 ENOG4105K8K Cupin 2, conserved barrel HPS44_RS23435 ENOG4108JQ6 ABC transporter HPS44_RS23440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS23445 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_RS23455 ENOG4105C26 Dehydrogenase HPS44_RS23460 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HPS44_RS23485 ENOG4105D4P Coproporphyrinogen iii oxidase HPS44_RS23490 ENOG41068CG regulatoR HPS44_RS23495 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HPS44_RS23500 ENOG4105C22 threonyL-tRNA synthetase HPS44_RS23505 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HPS44_RS23520 ENOG41080Z8 PHOSPHOCARRIER protein HPS44_RS23525 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPS44_RS23530 ENOG4105BZU Histidine kinase HPS44_RS23535 ENOG4108YZA Nitrogen regulatory protein pii HPS44_RS23545 ENOG4105W0Z cytoplasmic protein HPS44_RS23550 ENOG4105C0P Mg chelatase subunit ChlI HPS44_RS23555 ENOG4105VJV 50s ribosomal protein L35 HPS44_RS23560 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HPS44_RS23565 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HPS44_RS23570 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HPS44_RS23630 ENOG4108R6G acetyltransferase HPS44_RS23665 ENOG4108YXU transcriptional regulator AsnC family HPS44_RS23725 ENOG4105E2Y ABC, transporter HPS44_RS23740 ENOG4105C5Q Transcriptional regulator HPS44_RS23745 ENOG4105DHU Bile acid HPS44_RS23755 ENOG4108JJ7 ABC transporter HPS44_RS23760 ENOG4105CV8 reductase HPS44_RS23775 ENOG4108R1E Serine threonine protein phosphatase 1 HPS44_RS23780 ENOG4108JQC penicillin-binding protein 1A HPS44_RS23785 ENOG4105ID8 Transcriptional regulator, ARAC family HPS44_RS23790 ENOG4105EU0 Major facilitator Superfamily HPS44_RS23800 ENOG4105CND Glycosyl transferase, family 2 HPS44_RS23805 ENOG4107BJW polysaccharide deacetylase HPS44_RS23810 ENOG4108TUY outer membrane protein PgaA HPS44_RS23815 ENOG4105BZU Histidine kinase HPS44_RS23835 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HPS44_RS23840 ENOG4105KTH gatB Yqey HPS44_RS23850 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPS44_RS23855 ENOG4105C2D reductase HPS44_RS23865 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPS44_RS23905 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HPS44_RS23920 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPS44_RS23945 ENOG4105KPV Transcriptional regulator HPS44_RS23950 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_RS23955 ENOG4105SX7 Transporter HPS44_RS23960 ENOG41062BK proline dehydrogenase HPS44_RS23985 ENOG4107RDB Major Facilitator HPS44_RS23995 ENOG4105CBN LysR family transcriptional regulator HPS44_RS24020 ENOG4108IY8 ABC, transporter HPS44_RS24035 ENOG4105CSU acyl-Coa dehydrogenase HPS44_RS24040 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS24060 ENOG4105DSQ Nitric oxide reductase HPS44_RS24065 ENOG4105E6M Sulphatase-modifying factor protein HPS44_RS24080 ENOG4108W3Y Transcriptional regulator, Crp Fnr family HPS44_RS24090 ENOG4105MPD Cytochrome HPS44_RS24095 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HPS44_RS24100 ENOG4105DC8 reductase HPS44_RS24110 ENOG4105N14 lysine exporter protein LysE YggA HPS44_RS24125 ENOG4108Q5Y Membrane HPS44_RS24145 ENOG4107QI1 Mate efflux family protein HPS44_RS24150 ENOG4108IPT Naphthoate synthase HPS44_RS24155 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HPS44_RS24165 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPS44_RS24170 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HPS44_RS24180 ENOG4105CHR reductase HPS44_RS24215 ENOG4108K3Z AraC family transcriptional regulator HPS44_RS24230 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HPS44_RS24240 ENOG4108JQ1 Dehydrogenase HPS44_RS24245 ENOG4105JSC dimethylmenaquinone methyltransferase HPS44_RS24255 ENOG4105DMF Dehydrogenase HPS44_RS24280 ENOG4105EUB pirin domain protein HPS44_RS24295 ENOG4105KWW Biogenesis protein HPS44_RS24300 ENOG4107QX9 Thiol disulfide interChange protein HPS44_RS24305 ENOG4105DA4 cytochrome c-type biogenesis protein HPS44_RS24310 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HPS44_RS24320 ENOG41060IM Heme exporter protein HPS44_RS24325 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HPS44_RS24330 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HPS44_RS24345 ENOG4108J2R molybdopterin oxidoreductase HPS44_RS24350 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) HPS44_RS24355 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPS44_RS24360 ENOG4106WHD Tetrathionate reductase HPS44_RS24365 ENOG4105DB1 molybdopterin oxidoreductase HPS44_RS24370 ENOG4108M1T Cytochrome c-type biogenesis protein HPS44_RS24375 ENOG4105KWW Biogenesis protein HPS44_RS24380 ENOG4107QX9 Thiol disulfide interChange protein HPS44_RS24385 ENOG4105DA4 cytochrome c-type biogenesis protein HPS44_RS24400 ENOG41060IM Heme exporter protein HPS44_RS24405 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HPS44_RS24410 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HPS44_RS24425 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HPS44_RS24445 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_RS24450 ENOG4107RSM transcriptional regulator HPS44_RS24460 ENOG4105C01 Dihydroxy-acid dehydratase HPS44_RS24470 ENOG4105BZU Histidine kinase HPS44_RS24475 ENOG4105E39 Enoyl-CoA hydratase HPS44_RS24520 ENOG4107S01 Repressor protein MetJ HPS44_RS24530 ENOG4105CBN LysR family transcriptional regulator HPS44_RS24535 ENOG4105CY2 Citrate transporter HPS44_RS24540 ENOG4105CNM Receptor HPS44_RS24555 ENOG4105E09 nadh pyrophosphatase HPS44_RS24575 ENOG4108S8N class II Aldolase HPS44_RS24580 ENOG4105CSH Transporter HPS44_RS24600 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS24615 ENOG4105CHR reductase HPS44_RS24635 ENOG4105EW9 transcriptional regulator AsnC family HPS44_RS24640 ENOG4105CCF Lysine exporter protein (Lyse ygga) HPS44_RS24645 ENOG4108JJ7 ABC transporter HPS44_RS24650 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_RS24655 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPS44_RS24670 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS24675 ENOG4105CHR reductase HPS44_RS24710 ENOG4105ETT transcriptional Regulator, LysR family HPS44_RS24720 ENOG4105F04 LysR family Transcriptional regulator HPS44_RS24730 ENOG4105EJC lysr family transcriptional regulator HPS44_RS24740 ENOG4107RTG Major Facilitator superfamily HPS44_RS24745 ENOG4108IG5 Transcriptional regulator HPS44_RS24755 ENOG4105ETE Transcriptional regulator (LacI family HPS44_RS24760 ENOG4108SC4 )-transporter HPS44_RS24765 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HPS44_RS24815 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_RS24850 ENOG4105VUH addiction module killer protein HPS44_RS24870 ENOG4105C26 Dehydrogenase HPS44_RS24875 ENOG4108R6K riboflavin synthase, subunit alpha HPS44_RS24885 ENOG4105CSP Major Facilitator Superfamily HPS44_RS24895 ENOG4108MK9 spermidine N(1)-acetyltransferase HPS44_RS24905 ENOG4105W1Y Transcriptional regulator HPS44_RS24930 ENOG4105E0K tonB-dependent siderophore receptor HPS44_RS24935 ENOG4107R0V Pyruvate dehydrogenase HPS44_RS24940 ENOG4105CPP Dehydrogenase, E1 component HPS44_RS24945 ENOG4107QSN dihydrolipoamide acetyltransferase HPS44_RS24950 ENOG4107QN2 dihydrolipoyl dehydrogenase HPS44_RS24960 ENOG41063XI Toxic component of a toxin-antitoxin (TA) module. A HPS44_RS24965 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HPS44_RS24970 ENOG4105CH7 arginosuccinase HPS44_RS24975 ENOG4105CUY Mechanosensitive ion channel HPS44_RS24985 ENOG4108YZA Nitrogen regulatory protein pii HPS44_RS24990 ENOG4105D7Q type ii secretion system HPS44_RS24995 ENOG4105GVR general secretion pathway protein D HPS44_RS25000 ENOG4107QHF type ii secretion system protein e HPS44_RS25030 ENOG4108RTD type II secretion system protein K HPS44_RS25035 ENOG4108WWZ General secretion pathway protein J HPS44_RS25040 ENOG4105X5Z General secretion pathway protein I HPS44_RS25045 ENOG41069X0 general secretion pathway protein h HPS44_RS25050 ENOG4108VAU general secretion pathway protein G HPS44_RS25070 ENOG4105HSS phospholipase C HPS44_RS25075 ENOG4105DUM transcriptional regulator, lysR family HPS44_RS25080 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPS44_RS25085 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_RS25090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_RS25095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS25100 ENOG4108JQ6 ABC transporter HPS44_RS25105 ENOG4108VWS Yaeq family HPS44_RS25120 ENOG4105C57 major facilitator superfamily HPS44_RS25125 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HPS44_RS25130 ENOG4105FE9 pseudouridine synthase HPS44_RS25135 ENOG4105CR8 Transcriptional regulator HPS44_RS25140 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPS44_RS25145 ENOG4105BZS acriflavin resistance protein HPS44_RS25150 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPS44_RS25170 ENOG4105DGW oligopeptidase A HPS44_RS25175 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HPS44_RS25180 ENOG4108ZXC Two component transcriptional regulator, luxr family HPS44_RS25185 ENOG4105BZU Histidine kinase HPS44_RS25190 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HPS44_RS25195 ENOG4107QSN dihydrolipoamide acetyltransferase HPS44_RS25200 ENOG4107QN2 dihydrolipoyl dehydrogenase HPS44_RS25210 ENOG4105CBN LysR family transcriptional regulator HPS44_RS25260 ENOG4105FAW cDP-glucose 4,6-dehydratase HPS44_RS25270 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HPS44_RS25280 ENOG4105I03 Flagellin HPS44_RS25285 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPS44_RS25290 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HPS44_RS25295 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HPS44_RS25300 ENOG4107RD7 Flagellar Motor Protein, MotA HPS44_RS25305 ENOG4105ER2 Ompa motb domain protein HPS44_RS25310 ENOG4108VYJ response regulator receiver protein HPS44_RS25315 ENOG4105CBS Chea signal transduction histidine kinase HPS44_RS25320 ENOG4108V3W Chemotaxis protein, CheW HPS44_RS25325 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS25330 ENOG4105BZU Histidine kinase HPS44_RS25335 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HPS44_RS25340 ENOG4108VYJ response regulator receiver protein HPS44_RS25345 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HPS44_RS25350 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS25355 ENOG4105D00 flagellar biosynthetic protein flhB HPS44_RS25360 ENOG4105D7B Flagellar biosynthesis protein flha HPS44_RS25365 ENOG4105FZW flagellar biosynthesis regulator FlhF HPS44_RS25375 ENOG4105M9M anti-sigma28 factor FlgM HPS44_RS25385 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HPS44_RS25390 ENOG4108ZC9 flagellar basal-body rod protein flgc HPS44_RS25395 ENOG4105W00 Flagellar hook capping protein HPS44_RS25400 ENOG4105BZE flagellar hook protein, FlgE HPS44_RS25405 ENOG4108KPB Flagellar basal-body rod protein FlgF HPS44_RS25410 ENOG4105CGA flagellar basal-body rod protein FlgG HPS44_RS25425 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HPS44_RS25430 ENOG4105E1Q flagellar hook-associated protein HPS44_RS25435 ENOG4105DTJ flagellar hook-associated protein HPS44_RS25440 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS25445 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS25455 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS25460 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HPS44_RS25465 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HPS44_RS25470 ENOG4105VS8 Flagellar biosynthetic protein fliq HPS44_RS25475 ENOG4105CN7 Flagellar biosynthetic protein FliP HPS44_RS25480 ENOG4105K0P flagellar biosynthesis protein HPS44_RS25485 ENOG4105DD5 Flagellar motor switch protein HPS44_RS25490 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPS44_RS25495 ENOG4107ZI8 flagellar basal body-associated protein flil HPS44_RS25510 ENOG4108JIR Flagellum-specific ATP synthase HPS44_RS25520 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPS44_RS25525 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HPS44_RS25530 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HPS44_RS25540 ENOG4105D00 flagellar biosynthetic protein flhB HPS44_RS25555 ENOG4105MQ3 flagellar protein FliS HPS44_RS25560 ENOG4105DTS flagellar hook-associated HPS44_RS25565 ENOG41063QE flagellar protein FlaG HPS44_RS25570 ENOG4106P37 HTH-type transcriptional regulator YjhI HPS44_RS25580 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPS44_RS25595 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HPS44_RS25610 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HPS44_RS25615 ENOG4108VKG metal-dependent hydrolase HPS44_RS25620 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HPS44_RS25630 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HPS44_RS25635 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPS44_RS25645 ENOG4105CE9 30S ribosomal protein S2 HPS44_RS25650 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HPS44_RS25655 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HPS44_RS25660 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HPS44_RS25665 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HPS44_RS25670 ENOG4105KNE Phosphatidate cytidylyltransferase HPS44_RS25680 ENOG4105DZP Membrane-associated zinc metalloprotease HPS44_RS25685 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HPS44_RS25690 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HPS44_RS25695 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HPS44_RS25700 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HPS44_RS25715 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPS44_RS25750 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HPS44_RS25755 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPS44_RS25760 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPS44_RS25780 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HPS44_RS25785 ENOG4108Z1B Cyclase dehydrase HPS44_RS25800 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HPS44_RS25805 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPS44_RS25820 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HPS44_RS25825 ENOG4105HHA aminodeoxychorismate lyase HPS44_RS25830 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HPS44_RS25835 ENOG4105C6E dna polymerase iii HPS44_RS25840 ENOG4105F8V Hydrolase, tatD family HPS44_RS25855 ENOG4106TNF Periplasmic binding protein HPS44_RS25860 ENOG4105E5Q amino acid AbC transporter HPS44_RS25865 ENOG4105CDA abc transporter atp-binding protein HPS44_RS25870 ENOG41088SP formiminoglutamate hydrolase HPS44_RS25880 ENOG4105D82 Glutamate dehydrogenase HPS44_RS25890 ENOG4105DF9 Lipoate-protein, ligase HPS44_RS25905 ENOG4105CYM Glutathione S-transferase HPS44_RS25915 ENOG4108YXU transcriptional regulator AsnC family HPS44_RS25920 ENOG4108V06 Glutathione peroxidase HPS44_RS25925 ENOG4105F27 Major Facilitator HPS44_RS25930 ENOG4105WAP TPR repeat-containing protein HPS44_RS25940 ENOG4107S2N Type III effector Hrp-dependent HPS44_RS25945 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HPS44_RS25955 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HPS44_RS25960 ENOG4105CVP deoxyribo-dipyrimidine photolyase HPS44_RS25965 ENOG410846T CoA-transferase family III HPS44_RS25990 ENOG4108YZN class I peptide chain release factor HPS44_RS26000 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPS44_RS26030 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HPS44_RS26045 ENOG4107QWP ABC-2 type transporter HPS44_RS26050 ENOG4105CJ1 ABC, transporter HPS44_RS26065 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HPS44_RS26075 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HPS44_RS26085 ENOG4105E98 transcriptional regulator DeoR family HPS44_RS26090 ENOG4108IJ9 (ABC) transporter HPS44_RS26095 ENOG4108IJ9 (ABC) transporter HPS44_RS26145 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HPS44_RS26150 ENOG4108Z9W Outer membrane porin HPS44_RS26170 ENOG4108JU3 Alkyl hydroperoxide reductase HPS44_RS26175 ENOG41062ES Transcriptional regulator HPS44_RS26185 ENOG4105CBN LysR family transcriptional regulator HPS44_RS26190 ENOG4105C1G acyl-Coa dehydrogenase HPS44_RS26220 ENOG4105EW9 transcriptional regulator AsnC family HPS44_RS26225 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_RS26230 ENOG4107RH8 nuclease SbcCD subunit D HPS44_RS26260 ENOG4105D65 subunit l HPS44_RS26265 ENOG4108ZE9 Monovalent cation H antiporter subunit C HPS44_RS26270 ENOG4107R4Z monovalent cation h antiporter subunit d HPS44_RS26275 ENOG4105SC1 monovalent cation H antiporter subunit E HPS44_RS26280 ENOG4105W4C monovalent cation H antiporter subunit F HPS44_RS26285 ENOG4105KJM monovalent cation h antiporter subunit g HPS44_RS26295 ENOG4106TCE HPS44_RS26300 ENOG4108Z6B deaminase HPS44_RS26305 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPS44_RS26310 ENOG4105C5H ABC transporter HPS44_RS26345 ENOG41080RH Thioredoxin HPS44_RS26350 ENOG4105DEN Luciferase family HPS44_RS26360 ENOG4105C7N Xanthine uracil vitamin C permease HPS44_RS26370 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HPS44_RS26385 ENOG4108K5P (LipO)protein HPS44_RS26405 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPS44_RS26425 ENOG4105EHV domain protein HPS44_RS26435 ENOG4105D6S protein involved in catabolism of external DNA HPS44_RS26440 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HPS44_RS26450 ENOG4105EIN peptidylprolyl cis-trans isomerase HPS44_RS26455 ENOG4108UJV acyl-CoA thioesterase i HPS44_RS26460 ENOG4108I0Y (ABC) transporter HPS44_RS26470 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component HPS44_RS26475 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS26480 ENOG4105ETT transcriptional Regulator, LysR family HPS44_RS26485 ENOG4105EAC phosphoserine phosphatase HPS44_RS26500 ENOG4105DND Transcriptional regulator HPS44_RS26515 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_RS26530 ENOG4105DND Transcriptional regulator HPS44_RS26535 ENOG4105CFM UPF0317 protein HPS44_RS26545 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS26555 ENOG4105C0Z ABC transporter HPS44_RS26560 ENOG4108IV0 ABC, transporter HPS44_RS26565 ENOG4108Z9W Outer membrane porin HPS44_RS26570 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPS44_RS26585 ENOG4105E09 nadh pyrophosphatase HPS44_RS26610 ENOG4107R0W ABC transporter HPS44_RS26615 ENOG4105E5Q amino acid AbC transporter HPS44_RS26620 ENOG4105CDA abc transporter atp-binding protein HPS44_RS26625 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPS44_RS26630 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HPS44_RS26635 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HPS44_RS26650 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HPS44_RS26655 ENOG4105K4H Nlp p60 protein HPS44_RS26660 ENOG4105UGU tonB-dependent Receptor HPS44_RS26670 ENOG4105FYV Amp nucleosidase HPS44_RS26675 ENOG4108IQI permease HPS44_RS26685 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HPS44_RS26690 ENOG4105DSJ YicC domain protein HPS44_RS26695 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HPS44_RS26705 ENOG4105C1G acyl-Coa dehydrogenase HPS44_RS26715 ENOG4105BZU Histidine kinase HPS44_RS26720 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HPS44_RS26725 ENOG4105CSA Coproporphyrinogen iii oxidase HPS44_RS26735 ENOG4105CUX Signal transduction histidine kinase HPS44_RS26740 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_RS26745 ENOG4105EQ1 Transcriptional regulator HPS44_RS26755 ENOG4105EUB pirin domain protein HPS44_RS26760 ENOG4108S2Y peptide Chain Release factor HPS44_RS26775 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS26780 ENOG4105E0C molybdate abc transporter HPS44_RS26790 ENOG4105DP0 ferredoxin-NADP reductase HPS44_RS26810 ENOG4105DND Transcriptional regulator HPS44_RS26815 ENOG4105KME endoribonuclease L-psp HPS44_RS26820 ENOG4105CB5 ATP-dependent DNA helicase recG HPS44_RS26840 ENOG4106EYY HPS44_RS26845 ENOG4107TAE Glycosyl transferase (Group 1 HPS44_RS26870 ENOG4106PQC HPS44_RS26875 ENOG4105DBA pectate lyase HPS44_RS26885 ENOG4105CP9 extracellular ligand-binding receptor HPS44_RS26890 ENOG4107EXC regulatoR HPS44_RS26895 ENOG4105JJR Histidine kinase HPS44_RS26910 ENOG4108IJ9 (ABC) transporter HPS44_RS26920 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HPS44_RS26925 ENOG4105BZ7 extracellular solute-binding protein family 1 HPS44_RS26930 ENOG4105II7 pyrroline-5-carboxylate reductase HPS44_RS26935 ENOG4105EX9 Membrane HPS44_RS26945 ENOG4105CP9 extracellular ligand-binding receptor HPS44_RS26950 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS26955 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPS44_RS26960 ENOG4105C0Z ABC transporter HPS44_RS26965 ENOG4108IV0 ABC, transporter HPS44_RS26990 ENOG4105RQF LysR family Transcriptional regulator HPS44_RS26995 ENOG4108K3A Glutathione S-transferase HPS44_RS27000 ENOG4105D8V Glucose sorbosone dehydrogenase HPS44_RS27010 ENOG4105DJP Membrane HPS44_RS27035 ENOG4105CYW agmatinase HPS44_RS27045 ENOG4105D01 (LipO)protein HPS44_RS27055 ENOG4105F27 Major Facilitator HPS44_RS27065 ENOG4107RN3 metallophosphoesterase HPS44_RS27075 ENOG4105DJ4 phosphatidylserine decarboxylase HPS44_RS27080 ENOG4105C5H ABC transporter HPS44_RS27105 ENOG4105MWK D-amino acid dehydrogenase, small subunit HPS44_RS27110 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPS44_RS27115 ENOG4105BZU Histidine kinase HPS44_RS27130 ENOG4105D94 Major Facilitator Superfamily HPS44_RS27135 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HPS44_RS27155 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPS44_RS27160 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_RS27165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPS44_RS27215 ENOG4107R7Y intracellular protease Pfpi family HPS44_RS27235 ENOG4105C5I Dehydrogenase HPS44_RS27250 ENOG4105BZU Histidine kinase HPS44_RS27285 ENOG4106RE7 Cytochrome HPS44_RS27300 ENOG4105EE5 Membrane protein terC HPS44_RS27315 ENOG4105JJR Histidine kinase HPS44_RS27360 ENOG4108VAU general secretion pathway protein G HPS44_RS27385 ENOG4107QHF type ii secretion system protein e HPS44_RS27390 ENOG4105D7Q type ii secretion system HPS44_RS27395 ENOG4108UPW ABC transporter HPS44_RS27445 ENOG4105X5Z General secretion pathway protein I HPS44_RS27485 ENOG4105BZU Histidine kinase HPS44_RS27490 ENOG4108Z4X TRANSCRIPTIONal HPS44_RS27500 ENOG4105BZU Histidine kinase HPS44_RS27530 ENOG4108IY8 ABC, transporter HPS44_RS27535 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPS44_RS27540 ENOG4106FTQ Taurine ABC transporter, periplasmic HPS44_RS27565 ENOG4105CN1 protease HPS44_RS27585 ENOG4105IPI Membrane HPS44_RS27595 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPS44_RS27610 ENOG4107R7I amino acid HPS44_RS27655 ENOG4105KME endoribonuclease L-psp HPS44_RS27660 ENOG4105FC8 fad dependent oxidoreductase HPS44_RS27675 ENOG4105ERH Fumarylacetoacetate hydrolase HPS44_RS27705 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HPS44_RS27745 ENOG4108K3A Glutathione S-transferase HPS44_RS27750 ENOG4105DUM transcriptional regulator, lysR family HPS44_RS27760 ENOG4105CSH Transporter HPS44_RS27770 ENOG4105DWT malate dehydrogenase (quinone) HPS44_RS27800 ENOG4105CAU Arsenical resistance protein, ArsH HPS44_RS27810 ENOG4105D6J arsenicaL-resistance protein HPS44_RS27820 ENOG41085FC arsR family transcriptional regulator HPS44_RS27825 ENOG4105VN1 Heat shock protein HPS44_RS27860 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HPS44_RS27865 ENOG41080TK Universal stress protein HPS44_RS27880 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HPS44_RS27885 ENOG4105WH1 Two component transcriptional regulator luxr family HPS44_RS27900 ENOG41080XQ Signal transduction protein with cbs domains HPS44_RS27905 ENOG4105CY0 Metallo-Beta-Lactamase HPS44_RS27910 ENOG4108303 d-xylulose 5-phosphate d-fructose 6-phosphate phosphoketolase HPS44_RS27920 ENOG4108YV4 Universal stress protein HPS44_RS27930 ENOG41081QV Universal stress protein HPS44_RS27940 ENOG4105DZ0 fad dependent oxidoreductase HPS44_RS27960 ENOG4105CDA abc transporter atp-binding protein HPS44_RS27965 ENOG4105DRP amino acid AbC transporter HPS44_RS27970 ENOG4105EZ7 amino acid ABC transporter HPS44_RS27975 ENOG4107QXX ABC transporter HPS44_RS27980 ENOG4105C28 cystathionine HPS44_RS27985 ENOG4105RQF LysR family Transcriptional regulator HPS44_RS28005 ENOG4105C3U ABC transporter HPS44_RS28010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS28015 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPS44_RS28020 ENOG4105DEF Extracellular solute-binding protein, family 5 HPS44_RS28030 ENOG4105RQF LysR family Transcriptional regulator HPS44_RS28035 ENOG4105CHJ isochorismatase hydrolase HPS44_RS28040 ENOG41088CQ domain protein HPS44_RS28050 ENOG4105H1G trap transporter solute receptor taxi family HPS44_RS28055 ENOG4105DG7 nitrate ABC transporter HPS44_RS28060 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HPS44_RS28065 ENOG4105D7T ABC transporter HPS44_RS28075 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPS44_RS28085 ENOG4108PG2 copper resistance HPS44_RS28115 ENOG4105CTX dehydratase HPS44_RS28130 ENOG4105ECM Sensor protein basS pmrB HPS44_RS28135 ENOG4105ETX regulatoR HPS44_RS28145 ENOG4105EHG Permease protein HPS44_RS28150 ENOG41090JD Blue (Type 1) copper domain protein HPS44_RS28155 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPS44_RS28160 ENOG4105C7B Threonine dehydratase HPS44_RS28170 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HPS44_RS28175 ENOG4105E9K Isocitrate dehydrogenase HPS44_RS28180 ENOG4105DQR SNARE associated Golgi HPS44_RS28190 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HPS44_RS28195 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HPS44_RS28230 ENOG4105CNM Receptor HPS44_RS28245 ENOG4105TVJ transport system, permease HPS44_RS28250 ENOG4105E0A ABC, transporter HPS44_RS28255 ENOG4105CDA abc transporter atp-binding protein HPS44_RS28260 ENOG4105E5Q amino acid AbC transporter HPS44_RS28265 ENOG4105EAB amino acid AbC transporter HPS44_RS28270 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_RS28275 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPS44_RS28285 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HPS44_RS28295 ENOG4105CEY Amp-dependent synthetase and ligase HPS44_RS28310 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HPS44_RS28320 ENOG4105CMQ Chloride channel HPS44_RS28325 ENOG41067TZ transcriptional regulator, MarR family HPS44_RS28335 ENOG4105BZU Histidine kinase HPS44_RS28340 ENOG4108ZXC Two component transcriptional regulator, luxr family HPS44_RS28365 ENOG4107R11 Transcriptional regulator HPS44_RS28385 ENOG4105CDA abc transporter atp-binding protein HPS44_RS28395 ENOG4105E5Q amino acid AbC transporter HPS44_RS28440 ENOG4108UQ8 endoribonuclease L-psp HPS44_RS28480 ENOG4108KB2 LysR family Transcriptional regulator HPS44_RS28485 ENOG4105DTQ mandelate racemase muconate lactonizing HPS44_RS28495 ENOG4105DRR Transcriptional regulator, GntR family HPS44_RS28500 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HPS44_RS28515 ENOG4105JSC dimethylmenaquinone methyltransferase HPS44_RS28540 ENOG4105DG7 nitrate ABC transporter HPS44_RS28545 ENOG4105I5W Transporter HPS44_RS28550 ENOG4105D7T ABC transporter HPS44_RS28595 ENOG4105WH1 Two component transcriptional regulator luxr family HPS44_RS28600 ENOG4105BZU Histidine kinase HPS44_RS28605 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HPS44_RS28610 ENOG4107B2H carbonic anhydrase HPS44_RS28615 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HPS44_RS28620 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HPS44_RS28625 ENOG41076YT nitrate reductase, gamma subunit HPS44_RS28630 ENOG4105R3A Nitrate reductase HPS44_RS28635 ENOG4108IUE nitrate reductase beta subunit HPS44_RS28640 ENOG4105CRU nitrate reductase, alpha subunit HPS44_RS28645 ENOG4105DQQ Major facilitator superfamily MFS_1 HPS44_RS28670 ENOG4105HEI LysR family (Transcriptional regulator HPS44_RS28680 ENOG4105BZS acriflavin resistance protein HPS44_RS28685 ENOG4105BZS acriflavin resistance protein HPS44_RS28690 ENOG4105EMY transcriptional regulator HPS44_RS28730 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_RS28750 ENOG4105EA8 2-Nitropropane dioxygenase HPS44_RS28765 ENOG4105BZU Histidine kinase HPS44_RS28770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPS44_RS28775 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) HPS44_RS28780 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HPS44_RS28790 ENOG4105E0X reductase HPS44_RS28795 ENOG4107U7B Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HPS44_RS28840 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPS44_RS28845 ENOG4105T38 integral membrane protein HPS44_RS28850 ENOG4105VCD cytoplasmic protein HPS44_RS28855 ENOG4105D22 carbon starvation protein HPS44_RS28870 ENOG4105EUJ GTP cyclohydrolase i HPS44_RS28875 ENOG4105FDR Membrane HPS44_RS28880 ENOG4107NQ8 LysR family Transcriptional regulator HPS44_RS28885 ENOG4106FTQ Taurine ABC transporter, periplasmic HPS44_RS28895 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPS44_RS28920 ENOG4108S8N class II Aldolase HPS44_RS28925 ENOG4105I1J Autotransporter HPS44_RS28940 ENOG4105CKI cobalamin synthesis protein HPS44_RS28945 ENOG4105CI2 imidazolone-5-propionate hydrolase HPS44_RS28950 ENOG4108JQ6 ABC transporter HPS44_RS28955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPS44_RS28965 ENOG4108HIY periplasmic HPS44_RS28980 ENOG4108FUF Transcriptional regulator, IclR family HPS44_RS28985 ENOG4105C1J atp-dependent rna helicase HPS44_RS28990 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HPS44_RS29005 ENOG4105DSW Fusaric acid resistance protein HPS44_RS29010 ENOG4105ZQC membrane protein AaeX HPS44_RS29015 ENOG4105Y49 secretion protein, HlyD family HPS44_RS29030 ENOG4105C7K acetolactate synthase HPS44_RS29040 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HPS44_RS29050 ENOG4106KED esterase YpfH HPS44_RS29055 ENOG4108IQI permease HPS44_RS29060 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS29075 ENOG4105C0B DNA polymerase III (alpha subunit) HPS44_RS29090 ENOG4105EQ2 LysR family Transcriptional regulator HPS44_RS29095 ENOG4107S5I aldo keto reductase HPS44_RS29105 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HPS44_RS29130 ENOG4105DRP amino acid AbC transporter HPS44_RS29135 ENOG4105EAD ABC transporter HPS44_RS29140 ENOG4105EAB amino acid AbC transporter HPS44_RS29150 ENOG4105JSC dimethylmenaquinone methyltransferase HPS44_RS29200 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPS44_RS29205 ENOG4108VKM cytochrome b561 HPS44_RS29240 ENOG4105C8Q Methyl-accepting chemotaxis HPS44_RS29260 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPS44_RS29275 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HPS44_RS29280 ENOG4108IUZ ABC transporter HPS44_RS29285 ENOG4105C0Z ABC transporter HPS44_RS29290 ENOG4105C32 Amino acid ABC transporter (Permease) HPS44_RS29305 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HPS44_RS29325 ENOG4105E0K tonB-dependent siderophore receptor HPS44_RS29340 ENOG4108FUF Transcriptional regulator, IclR family HPS44_RS29350 ENOG4105CSH Transporter HPS44_RS29355 ENOG4105CPC Aldo Keto reductase HPS44_RS29370 ENOG4105PF9 Transcriptional regulator HPS44_RS29390 ENOG4105EWC Purine nucleoside phosphorylase HPS44_RS29400 ENOG4105R1U AraC Family Transcriptional Regulator HPS44_RS29415 ENOG4107R0U MotA TolQ exbB proton channel HPS44_RS29425 ENOG4105GRZ Ycii-related protein HPS44_RS29430 ENOG4105GRZ Ycii-related protein HPS44_RS29440 ENOG4105CHP RNA polymerase HPS44_RS29450 ENOG4105DXC membrane HPS44_RS29460 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HPS44_RS29470 ENOG4105DUM transcriptional regulator, lysR family HPS44_RS29495 ENOG4108K3A Glutathione S-transferase