locus-tag	class	description
HPS44_RS00045	COG1846	Transcriptional regulator
HPS44_RS00050	COG3541	Predicted nucleotidyltransferase
HPS44_RS00110	COG1360	Flagellar Motor Protein
HPS44_RS00120	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HPS44_RS00150	COG3501	Rhs element vgr protein
HPS44_RS00210	COG3501	Rhs element vgr protein
HPS44_RS00300	COG0625	glutathione transferase activity
HPS44_RS00305	COG2032	superoxide dismutase activity
HPS44_RS00310	COG2733	membrane
HPS44_RS00320	COG0148	phosphopyruvate hydratase activity
HPS44_RS00345	COG0583	DNA-binding transcription factor activity
HPS44_RS00350	COG1024	Enoyl-CoA hydratase
HPS44_RS00350	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_RS00355	COG0183	Belongs to the thiolase family
HPS44_RS00360	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS00365	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS00370	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS00395	COG0583	DNA-binding transcription factor activity
HPS44_RS00405	COG1846	Transcriptional regulator
HPS44_RS00410	COG0477	Major facilitator Superfamily
HPS44_RS00415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPS44_RS00415	COG2010	Cytochrome c
HPS44_RS00420	COG2080	2 iron, 2 sulfur cluster binding
HPS44_RS00430	COG0596	Alpha beta hydrolase
HPS44_RS00435	COG2309	aminopeptidase activity
HPS44_RS00440	COG1335	isochorismatase
HPS44_RS00445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPS44_RS00445	COG2010	Cytochrome c
HPS44_RS00455	COG1522	sequence-specific DNA binding
HPS44_RS00465	COG3842	ATPase activity
HPS44_RS00475	COG4149	molybdate abc transporter
HPS44_RS00480	COG5001	Diguanylate cyclase
HPS44_RS00480	COG2203	Gaf domain
HPS44_RS00480	COG4251	negative regulation of phosphorylation
HPS44_RS00480	COG3706	GGDEF domain
HPS44_RS00485	COG2201	protein-glutamate methylesterase activity
HPS44_RS00510	COG0840	transmembrane signaling receptor activity
HPS44_RS00515	COG0154	amidase activity
HPS44_RS00530	COG0583	DNA-binding transcription factor activity
HPS44_RS00560	COG0456	acetyltransferase
HPS44_RS00570	COG2203	Gaf domain
HPS44_RS00570	COG3706	GGDEF domain
HPS44_RS00570	COG4251	negative regulation of phosphorylation
HPS44_RS00570	COG5001	Diguanylate cyclase
HPS44_RS00595	COG0477	Major facilitator Superfamily
HPS44_RS00630	COG0165	Argininosuccinate lyase
HPS44_RS00645	COG0583	DNA-binding transcription factor activity
HPS44_RS00660	COG2205	protein histidine kinase activity
HPS44_RS00680	COG2207	Transcriptional regulator
HPS44_RS00685	COG2267	carboxylic ester hydrolase activity
HPS44_RS00695	COG4221	oxidoreductase activity
HPS44_RS00700	COG2207	Transcriptional regulator
HPS44_RS00740	COG0640	Transcriptional regulator
HPS44_RS00745	COG0640	Transcriptional regulator
HPS44_RS00755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPS44_RS00760	COG0583	DNA-binding transcription factor activity
HPS44_RS00765	COG0431	NADPH-dependent FMN reductase
HPS44_RS00785	COG4264	IucA IucC family
HPS44_RS00810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HPS44_RS00815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPS44_RS00820	COG1205	dead DEAH box helicase
HPS44_RS00820	COG1111	helicase
HPS44_RS00835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS44_RS00835	COG0519	Catalyzes the synthesis of GMP from XMP
HPS44_RS00865	COG0583	DNA-binding transcription factor activity
HPS44_RS00875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS44_RS00895	COG0583	DNA-binding transcription factor activity
HPS44_RS00900	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS00945	COG2072	flavoprotein involved in K transport
HPS44_RS00950	COG0601	transmembrane transport
HPS44_RS00955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_RS00965	COG4608	Belongs to the ABC transporter superfamily
HPS44_RS00970	COG0747	negative chemotaxis
HPS44_RS01000	COG4774	siderophore transport
HPS44_RS01020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS44_RS01045	COG0583	DNA-binding transcription factor activity
HPS44_RS01105	COG1024	Enoyl-CoA hydratase
HPS44_RS01110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_RS01115	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS01125	COG0583	DNA-binding transcription factor activity
HPS44_RS01130	COG3618	amidohydrolase
HPS44_RS01145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPS44_RS01170	COG5001	Diguanylate cyclase
HPS44_RS01175	COG4774	siderophore transport
HPS44_RS01180	COG4774	siderophore transport
HPS44_RS01195	COG0583	DNA-binding transcription factor activity
HPS44_RS01245	COG1953	Uracil, thiamine, allantoin
HPS44_RS01280	COG2205	protein histidine kinase activity
HPS44_RS01280	COG2198	Histidine kinase
HPS44_RS01280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS01280	COG0784	Response regulator, receiver
HPS44_RS01285	COG2205	protein histidine kinase activity
HPS44_RS01285	COG0745	RESPONSE REGULATOR receiver
HPS44_RS01285	COG3292	Two component regulator propeller
HPS44_RS01310	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS01315	COG0583	DNA-binding transcription factor activity
HPS44_RS01320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS01340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPS44_RS01355	COG0583	DNA-binding transcription factor activity
HPS44_RS01380	COG0745	RESPONSE REGULATOR receiver
HPS44_RS01400	COG0047	phosphoribosylformylglycinamidine synthase activity
HPS44_RS01400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPS44_RS01415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_RS01425	COG0613	PHP domain protein
HPS44_RS01440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS44_RS01450	COG0583	DNA-binding transcription factor activity
HPS44_RS01460	COG0583	DNA-binding transcription factor activity
HPS44_RS01465	COG0477	Major facilitator Superfamily
HPS44_RS01470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS44_RS01480	COG0159	tryptophan synthase activity
HPS44_RS01505	COG0277	FAD linked oxidase domain protein
HPS44_RS01520	COG3119	arylsulfatase activity
HPS44_RS01555	COG2149	membrane
HPS44_RS01580	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPS44_RS01590	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPS44_RS01595	COG0459	protein refolding
HPS44_RS01640	COG0714	Associated with various cellular activities
HPS44_RS01660	COG2304	oxidoreductase activity
HPS44_RS01675	COG3119	arylsulfatase activity
HPS44_RS01685	COG1280	lysine exporter protein (LysE YggA)
HPS44_RS01715	COG0633	Ferredoxin
HPS44_RS01725	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS01745	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPS44_RS01765	COG4604	ABC transporter, ATP-binding protein
HPS44_RS01770	COG4605	iron ion homeostasis
HPS44_RS01775	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_RS01780	COG4607	ABC-type enterochelin transport system periplasmic component
HPS44_RS01785	COG4771	TonB-dependent receptor
HPS44_RS01790	COG0745	RESPONSE REGULATOR receiver
HPS44_RS01800	COG0084	hydrolase, TatD family'
HPS44_RS01805	COG1136	(ABC) transporter
HPS44_RS01825	COG2271	Major facilitator Superfamily
HPS44_RS01835	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS01840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPS44_RS01855	COG3135	benzoate transporter
HPS44_RS01860	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPS44_RS01870	COG0183	Belongs to the thiolase family
HPS44_RS01875	COG1022	Amp-dependent synthetase and ligase
HPS44_RS01905	COG1024	Enoyl-CoA hydratase
HPS44_RS01915	COG1803	Methylglyoxal synthase
HPS44_RS01920	COG2975	iron-sulfur cluster assembly
HPS44_RS01925	COG0633	Ferredoxin
HPS44_RS01930	COG0443	Heat shock 70 kDa protein
HPS44_RS01935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPS44_RS01940	COG0316	Belongs to the HesB IscA family
HPS44_RS01945	COG0822	iron-sulfur transferase activity
HPS44_RS01950	COG1104	cysteine desulfurase activity
HPS44_RS01960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPS44_RS01965	COG0556	nucleotide-excision repair
HPS44_RS01975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPS44_RS01980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPS44_RS01985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPS44_RS01990	COG0740	serine-type endopeptidase activity
HPS44_RS01995	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPS44_RS02000	COG0501	Belongs to the peptidase M48B family
HPS44_RS02010	COG1278	Cold shock
HPS44_RS02020	COG1278	Cold shock
HPS44_RS02045	COG0251	oxidation-reduction process
HPS44_RS02055	COG0583	DNA-binding transcription factor activity
HPS44_RS02090	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HPS44_RS02115	COG0277	FAD linked oxidase domain protein
HPS44_RS02130	COG2814	Major facilitator Superfamily
HPS44_RS02165	COG2171	N-acyltransferase activity
HPS44_RS02175	COG2890	protein-(glutamine-N5) methyltransferase activity
HPS44_RS02180	COG0488	(ABC) transporter
HPS44_RS02195	COG4771	TonB-dependent receptor
HPS44_RS02200	COG4771	TonB-dependent receptor
HPS44_RS02205	COG4771	TonB-dependent receptor
HPS44_RS02215	COG1858	cytochrome C peroxidase
HPS44_RS02225	COG0210	DNA helicase
HPS44_RS02240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPS44_RS02240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS44_RS02245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPS44_RS02250	COG0196	riboflavin kinase activity
HPS44_RS02255	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPS44_RS02260	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPS44_RS02265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPS44_RS02320	COG1902	pentaerythritol trinitrate reductase activity
HPS44_RS02325	COG1126	abc transporter atp-binding protein
HPS44_RS02330	COG0765	amino acid transport
HPS44_RS02335	COG0765	amino acid transport
HPS44_RS02340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS02350	COG2423	ornithine cyclodeaminase activity
HPS44_RS02355	COG1764	response to oxidative stress
HPS44_RS02365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS44_RS02370	COG0625	glutathione transferase activity
HPS44_RS02380	COG4178	(ABC) transporter
HPS44_RS02390	COG4771	TonB-dependent receptor
HPS44_RS02405	COG2271	Major facilitator Superfamily
HPS44_RS02435	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPS44_RS02435	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPS44_RS02435	COG0506	proline dehydrogenase activity
HPS44_RS02445	COG3008	intermembrane lipid transfer
HPS44_RS02450	COG2995	paraquat-inducible protein a
HPS44_RS02460	COG4953	penicillin-binding protein 1C
HPS44_RS02470	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPS44_RS02475	COG1278	Cold shock
HPS44_RS02485	COG0183	Belongs to the thiolase family
HPS44_RS02490	COG0038	chloride channel
HPS44_RS02500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPS44_RS02510	COG1570	exodeoxyribonuclease VII activity
HPS44_RS02515	COG0811	peptide transport
HPS44_RS02525	COG1663	tetraacyldisaccharide 4'-kinase activity
HPS44_RS02535	COG2835	tetraacyldisaccharide 4'-kinase activity
HPS44_RS02540	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HPS44_RS02545	COG0563	adenylate kinase activity
HPS44_RS02555	COG0728	peptidoglycan biosynthetic process
HPS44_RS02565	COG0268	Binds directly to 16S ribosomal RNA
HPS44_RS02570	COG0583	DNA-binding transcription factor activity
HPS44_RS02585	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS02590	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS44_RS02595	COG2186	Transcriptional regulator
HPS44_RS02605	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS02615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS44_RS02645	COG3384	dioxygenase
HPS44_RS02650	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_RS02665	COG3971	2-oxopent-4-enoate hydratase activity
HPS44_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS02680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPS44_RS02685	COG1562	ergosterol biosynthetic process
HPS44_RS02690	COG1562	ergosterol biosynthetic process
HPS44_RS02700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPS44_RS02715	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS44_RS02730	COG5564	TIM-barrel signal transduction protein
HPS44_RS02735	COG5441	Belongs to the UPF0261 family
HPS44_RS02760	COG0542	response to heat
HPS44_RS02770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPS44_RS02780	COG0477	Major facilitator Superfamily
HPS44_RS02800	COG0494	nUDIX hydrolase
HPS44_RS02805	COG0583	DNA-binding transcription factor activity
HPS44_RS02810	COG0443	Heat shock 70 kDa protein
HPS44_RS02855	COG3530	Putative quorum-sensing-regulated virulence factor
HPS44_RS02870	COG0625	glutathione transferase activity
HPS44_RS02900	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS02910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS44_RS02960	COG1522	sequence-specific DNA binding
HPS44_RS02970	COG4172	Belongs to the ABC transporter superfamily
HPS44_RS02995	COG0519	Catalyzes the synthesis of GMP from XMP
HPS44_RS03015	COG0519	Catalyzes the synthesis of GMP from XMP
HPS44_RS03020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPS44_RS03025	COG2951	lytic endotransglycosylase activity
HPS44_RS03035	COG0583	DNA-binding transcription factor activity
HPS44_RS03045	COG2272	Belongs to the type-B carboxylesterase lipase family
HPS44_RS03050	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS03055	COG1309	transcriptional regulator
HPS44_RS03065	COG1473	amidohydrolase
HPS44_RS03075	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HPS44_RS03090	COG3618	amidohydrolase
HPS44_RS03095	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS03130	COG2011	ABC-type metal ion transport system permease component
HPS44_RS03135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPS44_RS03140	COG1464	Belongs to the NlpA lipoprotein family
HPS44_RS03150	COG2814	Major facilitator Superfamily
HPS44_RS03160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPS44_RS03165	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_RS03205	COG2837	iron assimilation
HPS44_RS03230	COG0583	DNA-binding transcription factor activity
HPS44_RS03235	COG2814	Major facilitator Superfamily
HPS44_RS03240	COG2169	Transcriptional regulator
HPS44_RS03270	COG1272	protein, Hemolysin III
HPS44_RS03295	COG4638	Rieske (2fe-2S)
HPS44_RS03310	COG0604	alcohol dehydrogenase
HPS44_RS03310	COG3321	synthase
HPS44_RS03325	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS03330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_RS03355	COG0183	Belongs to the thiolase family
HPS44_RS03370	COG0842	Transport permease protein
HPS44_RS03375	COG1131	(ABC) transporter
HPS44_RS03385	COG2197	response regulator
HPS44_RS03390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_RS03390	COG1116	anion transmembrane transporter activity
HPS44_RS03395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS03400	COG1116	anion transmembrane transporter activity
HPS44_RS03405	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HPS44_RS03425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_RS03455	COG0811	peptide transport
HPS44_RS03515	COG1396	sequence-specific DNA binding
HPS44_RS03520	COG0235	Class ii aldolase
HPS44_RS03530	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS03540	COG0583	DNA-binding transcription factor activity
HPS44_RS03560	COG0583	DNA-binding transcription factor activity
HPS44_RS03565	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS03610	COG1024	Enoyl-CoA hydratase
HPS44_RS03670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS44_RS03695	COG2084	Dehydrogenase
HPS44_RS03700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS44_RS03705	COG0683	leucine binding
HPS44_RS03765	COG4191	Histidine kinase
HPS44_RS03780	COG0583	DNA-binding transcription factor activity
HPS44_RS03830	COG3384	dioxygenase
HPS44_RS03875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS44_RS03880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPS44_RS03885	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS44_RS03900	COG1609	Transcriptional regulator
HPS44_RS03905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_RS03910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS44_RS03920	COG1850	ribulose-bisphosphate carboxylase activity
HPS44_RS03935	COG0505	Belongs to the CarA family
HPS44_RS03955	COG3608	succinylglutamate desuccinylase aspartoacylase
HPS44_RS03955	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPS44_RS03960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPS44_RS03975	COG2207	Transcriptional regulator
HPS44_RS03980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS04065	COG2192	nodulation
HPS44_RS04075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPS44_RS04080	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS04085	COG0438	transferase activity, transferring glycosyl groups
HPS44_RS04095	COG5265	(ABC) transporter
HPS44_RS04115	COG0668	transmembrane transport
HPS44_RS04125	COG0166	Belongs to the GPI family
HPS44_RS04135	COG3685	Protein conserved in bacteria
HPS44_RS04155	COG0387	Pfam Sodium calcium exchanger
HPS44_RS04160	COG3568	Endonuclease Exonuclease Phosphatase
HPS44_RS04165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS44_RS04170	COG0392	lysyltransferase activity
HPS44_RS04175	COG0297	glycogen (starch) synthase activity
HPS44_RS04180	COG0366	Alpha amylase catalytic
HPS44_RS04185	COG0366	Alpha amylase catalytic
HPS44_RS04200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPS44_RS04205	COG1640	4-alpha-glucanotransferase
HPS44_RS04215	COG1113	amino acid transport
HPS44_RS04240	COG1546	Belongs to the CinA family
HPS44_RS04240	COG1058	Belongs to the CinA family
HPS44_RS04250	COG3852	Histidine kinase
HPS44_RS04280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS44_RS04290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS44_RS04300	COG0477	Major facilitator Superfamily
HPS44_RS04315	COG4206	TonB-dependent receptor
HPS44_RS04380	COG1414	Transcriptional regulator
HPS44_RS04385	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS44_RS04390	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS04400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS44_RS04405	COG3958	Transketolase
HPS44_RS04410	COG3959	Transketolase, thiamine diphosphate binding domain
HPS44_RS04415	COG1802	Transcriptional regulator
HPS44_RS04420	COG0371	Dehydrogenase
HPS44_RS04425	COG3246	L-lysine catabolic process to acetate
HPS44_RS04435	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS04445	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_RS04460	COG3321	synthase
HPS44_RS04460	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS04460	COG0604	alcohol dehydrogenase
HPS44_RS04465	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS04495	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS04500	COG0583	DNA-binding transcription factor activity
HPS44_RS04505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPS44_RS04515	COG3384	dioxygenase
HPS44_RS04530	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPS44_RS04585	COG4964	Belongs to the GSP D family
HPS44_RS04630	COG1846	Transcriptional regulator
HPS44_RS04635	COG4172	Belongs to the ABC transporter superfamily
HPS44_RS04640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_RS04645	COG0601	transmembrane transport
HPS44_RS04660	COG0598	Magnesium transport protein CorA
HPS44_RS04680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS44_RS04695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPS44_RS04700	COG1045	serine acetyltransferase
HPS44_RS04705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPS44_RS04710	COG0166	Belongs to the GPI family
HPS44_RS04715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPS44_RS04720	COG3206	protein involved in exopolysaccharide biosynthesis
HPS44_RS04720	COG0489	protein tyrosine kinase activity
HPS44_RS04725	COG1596	polysaccharide export
HPS44_RS04735	COG1051	belongs to the nudix hydrolase family
HPS44_RS04755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS44_RS04780	COG0463	Glycosyl transferase, family 2
HPS44_RS04785	COG0110	maltose O-acetyltransferase activity
HPS44_RS04790	COG0297	glycogen (starch) synthase activity
HPS44_RS04795	COG2197	response regulator
HPS44_RS04800	COG2197	response regulator
HPS44_RS04810	COG1309	transcriptional regulator
HPS44_RS04815	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS04825	COG1024	Enoyl-CoA hydratase
HPS44_RS04825	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_RS04835	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_RS04835	COG1024	Enoyl-CoA hydratase
HPS44_RS04840	COG0183	Belongs to the thiolase family
HPS44_RS04855	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS04865	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS04875	COG1132	(ABC) transporter
HPS44_RS04885	COG3395	kinase activity
HPS44_RS04890	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS44_RS04900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS44_RS04905	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPS44_RS04910	COG1024	Enoyl-CoA hydratase
HPS44_RS04920	COG1414	Transcriptional regulator
HPS44_RS04930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPS44_RS04950	COG0583	DNA-binding transcription factor activity
HPS44_RS04990	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPS44_RS04995	COG1309	transcriptional regulator
HPS44_RS05005	COG1051	belongs to the nudix hydrolase family
HPS44_RS05010	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HPS44_RS05020	COG2205	protein histidine kinase activity
HPS44_RS05020	COG0784	Response regulator, receiver
HPS44_RS05030	COG0784	Response regulator, receiver
HPS44_RS05030	COG2205	protein histidine kinase activity
HPS44_RS05045	COG2863	cytochrome
HPS44_RS05050	COG3258	Cytochrome c
HPS44_RS05065	COG3278	Belongs to the heme-copper respiratory oxidase family
HPS44_RS05085	COG0348	domain, Protein
HPS44_RS05105	COG4695	Portal protein
HPS44_RS05285	COG0527	aspartate kinase activity
HPS44_RS05290	COG0037	tRNA processing
HPS44_RS05295	COG0825	malonyl-CoA metabolic process
HPS44_RS05305	COG0215	cysteine-tRNA ligase activity
HPS44_RS05320	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPS44_RS05325	COG1968	undecaprenyl-diphosphatase activity
HPS44_RS05330	COG1253	flavin adenine dinucleotide binding
HPS44_RS05345	COG4263	nitrous-oxide reductase activity
HPS44_RS05360	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HPS44_RS05370	COG1477	protein flavinylation
HPS44_RS05375	COG4804	nuclease activity
HPS44_RS05400	COG0668	transmembrane transport
HPS44_RS05440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_RS05445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS05450	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS44_RS05485	COG3360	Dodecin
HPS44_RS05495	COG0583	DNA-binding transcription factor activity
HPS44_RS05500	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS05550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPS44_RS05555	COG2850	peptidyl-arginine hydroxylation
HPS44_RS05565	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPS44_RS05570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_RS05575	COG1994	Peptidase M50
HPS44_RS05580	COG0009	L-threonylcarbamoyladenylate synthase
HPS44_RS05585	COG2321	neutral zinc metallopeptidase
HPS44_RS05645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS44_RS05650	COG3969	phosphoadenosine phosphosulfate
HPS44_RS05660	COG1475	DNA binding
HPS44_RS05665	COG0642	Histidine kinase
HPS44_RS05685	COG3188	usher protein
HPS44_RS05690	COG3121	Chaperone
HPS44_RS05705	COG3300	MHYT domain
HPS44_RS05705	COG5001	Diguanylate cyclase
HPS44_RS05715	COG2197	response regulator
HPS44_RS05745	COG3121	Chaperone
HPS44_RS05750	COG3188	usher protein
HPS44_RS05785	COG4221	oxidoreductase activity
HPS44_RS05790	COG3387	PFAM Glycoside hydrolase 15-related
HPS44_RS05805	COG0840	transmembrane signaling receptor activity
HPS44_RS05810	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS05815	COG1280	lysine exporter protein (LysE YggA)
HPS44_RS05830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS44_RS05850	COG2084	Dehydrogenase
HPS44_RS05865	COG1802	Transcriptional regulator
HPS44_RS05880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS44_RS05905	COG0745	RESPONSE REGULATOR receiver
HPS44_RS05910	COG2205	protein histidine kinase activity
HPS44_RS05915	COG1764	response to oxidative stress
HPS44_RS05920	COG0583	DNA-binding transcription factor activity
HPS44_RS05925	COG0601	transmembrane transport
HPS44_RS05930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_RS05935	COG0444	Belongs to the ABC transporter superfamily
HPS44_RS05940	COG4608	Belongs to the ABC transporter superfamily
HPS44_RS05955	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_RS05960	COG0586	Pfam SNARE associated Golgi protein
HPS44_RS05965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS05970	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HPS44_RS06020	COG3546	catalase activity
HPS44_RS06055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPS44_RS06080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_RS06085	COG0765	amino acid transport
HPS44_RS06095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS06105	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_RS06130	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS06150	COG0348	domain, Protein
HPS44_RS06170	COG3278	Belongs to the heme-copper respiratory oxidase family
HPS44_RS06185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPS44_RS06190	COG0156	8-amino-7-oxononanoate synthase activity
HPS44_RS06215	COG2224	Isocitrate lyase
HPS44_RS06225	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPS44_RS06225	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HPS44_RS06230	COG1858	cytochrome C peroxidase
HPS44_RS06235	COG0583	DNA-binding transcription factor activity
HPS44_RS06240	COG0473	3-isopropylmalate dehydrogenase activity
HPS44_RS06250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPS44_RS06265	COG0736	holo-[acyl-carrier-protein] synthase activity
HPS44_RS06270	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPS44_RS06280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS44_RS06285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_RS06310	COG3842	ATPase activity
HPS44_RS06315	COG4149	molybdate abc transporter
HPS44_RS06320	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPS44_RS06325	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HPS44_RS06350	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPS44_RS06360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_RS06370	COG4120	Belongs to the binding-protein-dependent transport system permease family
HPS44_RS06380	COG0667	Aldo Keto reductase
HPS44_RS06390	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS06395	COG1024	Enoyl-CoA hydratase
HPS44_RS06405	COG1802	Transcriptional regulator
HPS44_RS06415	COG0183	Belongs to the thiolase family
HPS44_RS06420	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS06425	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS06430	COG0583	DNA-binding transcription factor activity
HPS44_RS06455	COG4213	ABC transporter substrate-binding protein
HPS44_RS06460	COG1129	ABC transporter
HPS44_RS06465	COG4214	carbohydrate transport
HPS44_RS06470	COG2706	6-phosphogluconolactonase activity
HPS44_RS06475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS44_RS06490	COG3448	diguanylate cyclase activity
HPS44_RS06490	COG4175	Glycine betaine
HPS44_RS06495	COG4176	ABC-type proline glycine betaine transport system permease component
HPS44_RS06505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS44_RS06510	COG2814	Major facilitator Superfamily
HPS44_RS06515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPS44_RS06520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPS44_RS06555	COG1686	Belongs to the peptidase S11 family
HPS44_RS06565	COG1846	Transcriptional regulator
HPS44_RS06570	COG2814	Major facilitator Superfamily
HPS44_RS06575	COG0495	leucyl-tRNA aminoacylation
HPS44_RS06590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPS44_RS06610	COG0154	amidase activity
HPS44_RS06620	COG0477	Major facilitator Superfamily
HPS44_RS06630	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_RS06645	COG0583	DNA-binding transcription factor activity
HPS44_RS06695	COG0583	DNA-binding transcription factor activity
HPS44_RS06700	COG0427	acetyl-CoA hydrolase
HPS44_RS06705	COG0583	DNA-binding transcription factor activity
HPS44_RS06710	COG1511	domain protein
HPS44_RS06710	COG3264	Mechanosensitive ion channel
HPS44_RS06760	COG3842	ATPase activity
HPS44_RS06770	COG1177	transmembrane transport
HPS44_RS06775	COG3938	Belongs to the proline racemase family
HPS44_RS06790	COG0517	IMP dehydrogenase activity
HPS44_RS06820	COG0500	methyltransferase
HPS44_RS06830	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HPS44_RS06845	COG0667	Aldo Keto reductase
HPS44_RS06850	COG2207	Transcriptional regulator
HPS44_RS06860	COG1595	DNA-templated transcription, initiation
HPS44_RS06875	COG2841	Protein conserved in bacteria
HPS44_RS06890	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS44_RS06895	COG0438	transferase activity, transferring glycosyl groups
HPS44_RS06910	COG2814	Major facilitator Superfamily
HPS44_RS06915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPS44_RS06940	COG0248	Ppx GppA phosphatase
HPS44_RS06950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPS44_RS06960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPS44_RS06965	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HPS44_RS06970	COG1534	Rna-binding protein
HPS44_RS06975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPS44_RS06980	COG0840	transmembrane signaling receptor activity
HPS44_RS06985	COG2233	PERMEase
HPS44_RS07005	COG3842	ATPase activity
HPS44_RS07020	COG4221	oxidoreductase activity
HPS44_RS07030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPS44_RS07035	COG0505	Belongs to the CarA family
HPS44_RS07055	COG0745	RESPONSE REGULATOR receiver
HPS44_RS07070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS07080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_RS07085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_RS07100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPS44_RS07110	COG1074	ATP-dependent DNA helicase activity
HPS44_RS07130	COG2070	2-Nitropropane dioxygenase
HPS44_RS07150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_RS07165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS44_RS07170	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS07185	COG1686	Belongs to the peptidase S11 family
HPS44_RS07205	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HPS44_RS07210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPS44_RS07215	COG4974	Belongs to the 'phage' integrase family
HPS44_RS07220	COG0583	DNA-binding transcription factor activity
HPS44_RS07225	COG0028	Belongs to the TPP enzyme family
HPS44_RS07270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPS44_RS07315	COG0028	Belongs to the TPP enzyme family
HPS44_RS07320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS07335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS44_RS07340	COG1414	Transcriptional regulator
HPS44_RS07345	COG0009	L-threonylcarbamoyladenylate synthase
HPS44_RS07350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPS44_RS07355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPS44_RS07360	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPS44_RS07370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPS44_RS07390	COG1301	dicarboxylic acid transport
HPS44_RS07400	COG3454	Phosphonate metabolism
HPS44_RS07405	COG4778	phosphonate C-P lyase system protein PhnL
HPS44_RS07410	COG4107	phosphonate C-P lyase system protein PhnK
HPS44_RS07415	COG3627	carbon phosphorus lyase activity
HPS44_RS07420	COG3626	phosphonate metabolism
HPS44_RS07425	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HPS44_RS07430	COG3624	Phosphonate C-P lyase system protein PhnG
HPS44_RS07435	COG2188	Transcriptional regulator
HPS44_RS07440	COG3454	Phosphonate metabolism
HPS44_RS07445	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HPS44_RS07450	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HPS44_RS07455	COG0583	DNA-binding transcription factor activity
HPS44_RS07460	COG0405	Gamma-glutamyltransferase
HPS44_RS07475	COG3639	organic phosphonate transmembrane transporter activity
HPS44_RS07480	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HPS44_RS07485	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HPS44_RS07495	COG0640	Transcriptional regulator
HPS44_RS07505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPS44_RS07515	COG0739	heme binding
HPS44_RS07525	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPS44_RS07535	COG0306	phosphate transporter
HPS44_RS07570	COG0625	glutathione transferase activity
HPS44_RS07590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPS44_RS07595	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPS44_RS07610	COG0126	phosphoglycerate kinase activity
HPS44_RS07615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPS44_RS07620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPS44_RS07630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPS44_RS07635	COG2732	(Barnase) inhibitor
HPS44_RS07645	COG0280	phosphate acetyltransferase
HPS44_RS07645	COG0281	malic enzyme
HPS44_RS07670	COG0741	lytic transglycosylase activity
HPS44_RS07675	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPS44_RS07690	COG4575	ribosome binding
HPS44_RS07700	COG1116	anion transmembrane transporter activity
HPS44_RS07705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS07710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_RS07715	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPS44_RS07715	COG1648	precorrin-2 dehydrogenase activity
HPS44_RS07720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPS44_RS07725	COG2027	D-alanyl-D-alanine carboxypeptidase
HPS44_RS07740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS44_RS07750	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPS44_RS07755	COG0343	queuine tRNA-ribosyltransferase activity
HPS44_RS07765	COG3077	Addiction module antitoxin, RelB DinJ family
HPS44_RS07770	COG1862	Preprotein translocase
HPS44_RS07775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS44_RS07780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS44_RS07800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPS44_RS07820	COG1702	phosphate starvation-inducible protein PhoH
HPS44_RS07825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPS44_RS07830	COG4535	Mg2 and Co2 transporter CorC
HPS44_RS07835	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPS44_RS07840	COG0667	Aldo Keto reductase
HPS44_RS07885	COG0697	spore germination
HPS44_RS07895	COG0678	peroxiredoxin activity
HPS44_RS07905	COG0412	Dienelactone hydrolase
HPS44_RS07915	COG0315	cyclic pyranopterin monophosphate synthase activity
HPS44_RS07925	COG0314	molybdopterin synthase activity
HPS44_RS07930	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPS44_RS07935	COG0303	'Molybdopterin
HPS44_RS07945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPS44_RS07965	COG3383	formate dehydrogenase (NAD+) activity
HPS44_RS07970	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HPS44_RS07980	COG2223	nitrite transmembrane transporter activity
HPS44_RS08005	COG0583	DNA-binding transcription factor activity
HPS44_RS08010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPS44_RS08025	COG2205	protein histidine kinase activity
HPS44_RS08030	COG0745	RESPONSE REGULATOR receiver
HPS44_RS08045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPS44_RS08060	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS08080	COG2828	Protein conserved in bacteria
HPS44_RS08085	COG0583	DNA-binding transcription factor activity
HPS44_RS08130	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_RS08155	COG4774	siderophore transport
HPS44_RS08170	COG0671	phosphoesterase, PA-phosphatase related
HPS44_RS08185	COG1666	GTP binding
HPS44_RS08190	COG1120	ATPase activity
HPS44_RS08195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_RS08200	COG4558	Periplasmic binding protein
HPS44_RS08205	COG3720	iron ion transport
HPS44_RS08215	COG3712	iron ion homeostasis
HPS44_RS08220	COG1595	DNA-templated transcription, initiation
HPS44_RS08235	COG2378	regulation of single-species biofilm formation
HPS44_RS08260	COG0583	DNA-binding transcription factor activity
HPS44_RS08265	COG1113	amino acid transport
HPS44_RS08275	COG1522	sequence-specific DNA binding
HPS44_RS08280	COG1272	protein, Hemolysin III
HPS44_RS08285	COG3191	aminopeptidase activity
HPS44_RS08290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS08295	COG0765	amino acid transport
HPS44_RS08305	COG4942	peptidase
HPS44_RS08325	COG1999	signal sequence binding
HPS44_RS08340	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HPS44_RS08350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS44_RS08355	COG1845	cytochrome c oxidase, subunit III
HPS44_RS08360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPS44_RS08400	COG0281	malic enzyme
HPS44_RS08400	COG0280	phosphate acetyltransferase
HPS44_RS08415	COG0697	spore germination
HPS44_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS08460	COG0583	DNA-binding transcription factor activity
HPS44_RS08480	COG1396	sequence-specific DNA binding
HPS44_RS08485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS44_RS08510	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPS44_RS08525	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPS44_RS08530	COG1285	pathogenesis
HPS44_RS08535	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS08540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS44_RS08555	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPS44_RS08570	COG3712	iron ion homeostasis
HPS44_RS08575	COG1595	DNA-templated transcription, initiation
HPS44_RS08585	COG4221	oxidoreductase activity
HPS44_RS08590	COG4773	Receptor
HPS44_RS08610	COG5001	Diguanylate cyclase
HPS44_RS08615	COG0330	HflC and HflK could
HPS44_RS08640	COG2807	transmembrane transport
HPS44_RS08645	COG2207	Transcriptional regulator
HPS44_RS08650	COG4106	trans-aconitate 2-methyltransferase activity
HPS44_RS08665	COG0583	DNA-binding transcription factor activity
HPS44_RS08705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPS44_RS08710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS08715	COG0477	Major facilitator Superfamily
HPS44_RS08720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPS44_RS08725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS44_RS08730	COG1845	cytochrome c oxidase, subunit III
HPS44_RS08735	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPS44_RS08745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_RS08750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_RS08755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_RS08765	COG2814	Major facilitator Superfamily
HPS44_RS08780	COG0625	glutathione transferase activity
HPS44_RS08840	COG3707	response regulator
HPS44_RS08845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPS44_RS08845	COG2146	nitrite reductase [NAD(P)H] activity
HPS44_RS08850	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPS44_RS08850	COG2146	nitrite reductase [NAD(P)H] activity
HPS44_RS08855	COG0243	molybdopterin cofactor binding
HPS44_RS08865	COG0667	Aldo Keto reductase
HPS44_RS08885	COG0583	DNA-binding transcription factor activity
HPS44_RS08890	COG0023	Translation Initiation Factor
HPS44_RS08900	COG0456	acetyltransferase
HPS44_RS08900	COG0454	-acetyltransferase
HPS44_RS08905	COG0583	DNA-binding transcription factor activity
HPS44_RS08910	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_RS08925	COG0840	transmembrane signaling receptor activity
HPS44_RS08930	COG2199	diguanylate cyclase activity
HPS44_RS08930	COG2203	Gaf domain
HPS44_RS08935	COG0640	Transcriptional regulator
HPS44_RS08945	COG0740	serine-type endopeptidase activity
HPS44_RS08950	COG2814	Major facilitator Superfamily
HPS44_RS08980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_RS08990	COG0596	Alpha beta hydrolase
HPS44_RS09000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPS44_RS09010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS44_RS09015	COG0583	DNA-binding transcription factor activity
HPS44_RS09050	COG0028	Belongs to the TPP enzyme family
HPS44_RS09070	COG1230	cation diffusion facilitator family transporter
HPS44_RS09090	COG1132	(ABC) transporter
HPS44_RS09100	COG1201	RNA secondary structure unwinding
HPS44_RS09105	COG1793	dna ligase
HPS44_RS09110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPS44_RS09110	COG1793	dna ligase
HPS44_RS09145	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS09155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_RS09160	COG0697	spore germination
HPS44_RS09170	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS09180	COG0436	Aminotransferase
HPS44_RS09185	COG0583	DNA-binding transcription factor activity
HPS44_RS09190	COG0583	DNA-binding transcription factor activity
HPS44_RS09215	COG0583	DNA-binding transcription factor activity
HPS44_RS09220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_RS09225	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS09230	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_RS09245	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS09290	COG1595	DNA-templated transcription, initiation
HPS44_RS09325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPS44_RS09375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPS44_RS09405	COG2200	EAL domain
HPS44_RS09425	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS44_RS09430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS09440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPS44_RS09445	COG0459	protein refolding
HPS44_RS09455	COG1846	Transcriptional regulator
HPS44_RS09475	COG1917	Cupin 2, conserved barrel domain protein
HPS44_RS09500	COG1137	ATPase activity
HPS44_RS09510	COG0246	Mannitol dehydrogenase
HPS44_RS09515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPS44_RS09520	COG1252	NADH dehydrogenase
HPS44_RS09525	COG0284	orotidine-5'-phosphate decarboxylase activity
HPS44_RS09530	COG1546	Belongs to the CinA family
HPS44_RS09545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS44_RS09550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPS44_RS09575	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HPS44_RS09580	COG3639	organic phosphonate transmembrane transporter activity
HPS44_RS09585	COG3639	organic phosphonate transmembrane transporter activity
HPS44_RS09600	COG0742	ribosomal rna small subunit methyltransferase
HPS44_RS09605	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPS44_RS09610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPS44_RS09615	COG3135	benzoate transporter
HPS44_RS09630	COG2814	Major facilitator Superfamily
HPS44_RS09650	COG4773	Receptor
HPS44_RS09655	COG4804	nuclease activity
HPS44_RS09660	COG0012	GTP binding
HPS44_RS09670	COG0193	aminoacyl-tRNA hydrolase activity
HPS44_RS09690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPS44_RS09695	COG0840	transmembrane signaling receptor activity
HPS44_RS09710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPS44_RS09735	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HPS44_RS09745	COG0204	Acyl-transferase
HPS44_RS09750	COG1368	sulfuric ester hydrolase activity
HPS44_RS09755	COG2186	Transcriptional regulator
HPS44_RS09760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS44_RS09770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_RS09780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS44_RS09790	COG2205	protein histidine kinase activity
HPS44_RS09795	COG0745	RESPONSE REGULATOR receiver
HPS44_RS09800	COG0277	FAD linked oxidase domain protein
HPS44_RS09815	COG0166	Belongs to the GPI family
HPS44_RS09820	COG0405	Gamma-glutamyltransferase
HPS44_RS09825	COG0438	transferase activity, transferring glycosyl groups
HPS44_RS09830	COG0438	transferase activity, transferring glycosyl groups
HPS44_RS09835	COG0438	transferase activity, transferring glycosyl groups
HPS44_RS09860	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPS44_RS09865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPS44_RS09895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS09915	COG0747	negative chemotaxis
HPS44_RS09920	COG0601	transmembrane transport
HPS44_RS09925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_RS09930	COG4172	Belongs to the ABC transporter superfamily
HPS44_RS09935	COG0154	amidase activity
HPS44_RS09975	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPS44_RS09975	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPS44_RS09980	COG0509	glycine decarboxylation via glycine cleavage system
HPS44_RS09985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPS44_RS10000	COG2081	HI0933 family
HPS44_RS10005	COG1982	Orn Lys Arg decarboxylase major
HPS44_RS10020	COG3706	GGDEF domain
HPS44_RS10030	COG0717	Belongs to the dCTP deaminase family
HPS44_RS10045	COG0489	protein tyrosine kinase activity
HPS44_RS10055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS44_RS10055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS44_RS10075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HPS44_RS10075	COG2755	lipolytic protein G-D-S-L family
HPS44_RS10090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPS44_RS10095	COG2200	EAL domain
HPS44_RS10100	COG1595	DNA-templated transcription, initiation
HPS44_RS10110	COG4774	siderophore transport
HPS44_RS10130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_RS10135	COG1129	ABC transporter
HPS44_RS10135	COG0842	Transport permease protein
HPS44_RS10140	COG0842	Transport permease protein
HPS44_RS10150	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS10155	COG0583	DNA-binding transcription factor activity
HPS44_RS10160	COG0697	spore germination
HPS44_RS10170	COG1271	oxidase subunit
HPS44_RS10175	COG1294	oxidase, subunit
HPS44_RS10185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS10220	COG3258	Cytochrome c
HPS44_RS10230	COG0625	glutathione transferase activity
HPS44_RS10235	COG2986	histidine ammonia-lyase
HPS44_RS10240	COG1234	tRNA 3'-trailer cleavage
HPS44_RS10250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPS44_RS10265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPS44_RS10290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPS44_RS10310	COG1595	DNA-templated transcription, initiation
HPS44_RS10315	COG3712	iron ion homeostasis
HPS44_RS10325	COG0165	Argininosuccinate lyase
HPS44_RS10330	COG2205	protein histidine kinase activity
HPS44_RS10335	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS10340	COG3246	L-lysine catabolic process to acetate
HPS44_RS10355	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPS44_RS10360	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS44_RS10365	COG0154	amidase activity
HPS44_RS10370	COG0372	Belongs to the citrate synthase family
HPS44_RS10375	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_RS10400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS44_RS10405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_RS10410	COG0583	DNA-binding transcription factor activity
HPS44_RS10415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPS44_RS10435	COG1652	LysM domain
HPS44_RS10440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPS44_RS10445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPS44_RS10455	COG0625	glutathione transferase activity
HPS44_RS10485	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_RS10535	COG1414	Transcriptional regulator
HPS44_RS10545	COG0800	Aldolase
HPS44_RS10550	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_RS10555	COG2271	Major facilitator Superfamily
HPS44_RS10560	COG1131	(ABC) transporter
HPS44_RS10575	COG4774	siderophore transport
HPS44_RS10580	COG2814	Major facilitator Superfamily
HPS44_RS10585	COG0326	Molecular chaperone. Has ATPase activity
HPS44_RS10595	COG2233	PERMEase
HPS44_RS10625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS44_RS10680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPS44_RS10690	COG3657	addiction module killer protein
HPS44_RS10705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS10715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_RS10720	COG3246	L-lysine catabolic process to acetate
HPS44_RS10730	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS10840	COG2198	Histidine kinase
HPS44_RS10840	COG0784	Response regulator, receiver
HPS44_RS10840	COG5002	protein histidine kinase activity
HPS44_RS10870	COG0583	DNA-binding transcription factor activity
HPS44_RS10880	COG1695	Transcriptional regulator
HPS44_RS10895	COG0477	Major facilitator Superfamily
HPS44_RS10910	COG0277	FAD linked oxidase domain protein
HPS44_RS10920	COG3842	ATPase activity
HPS44_RS10925	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS44_RS10945	COG0628	permease
HPS44_RS10950	COG0583	DNA-binding transcription factor activity
HPS44_RS10955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_RS11005	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HPS44_RS11015	COG2186	Transcriptional regulator
HPS44_RS11025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS44_RS11050	COG0410	ABC transporter
HPS44_RS11055	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS11060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPS44_RS11070	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS44_RS11080	COG0583	DNA-binding transcription factor activity
HPS44_RS11085	COG0129	dihydroxy-acid dehydratase activity
HPS44_RS11095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS44_RS11100	COG0583	DNA-binding transcription factor activity
HPS44_RS11115	COG2200	EAL domain
HPS44_RS11120	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HPS44_RS11125	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPS44_RS11130	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_RS11135	COG2031	fatty acid transporter
HPS44_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS11145	COG1414	Transcriptional regulator
HPS44_RS11155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS44_RS11160	COG4829	muconolactone delta-isomerase
HPS44_RS11170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS44_RS11190	COG0288	reversible hydration of carbon dioxide
HPS44_RS11195	COG1802	Transcriptional regulator
HPS44_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS11210	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_RS11245	COG0625	glutathione transferase activity
HPS44_RS11260	COG0583	DNA-binding transcription factor activity
HPS44_RS11270	COG0583	DNA-binding transcription factor activity
HPS44_RS11275	COG0477	Major facilitator Superfamily
HPS44_RS11300	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS11320	COG1464	Belongs to the NlpA lipoprotein family
HPS44_RS11335	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPS44_RS11340	COG2890	protein-(glutamine-N5) methyltransferase activity
HPS44_RS11345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPS44_RS11360	COG1280	lysine exporter protein (LysE YggA)
HPS44_RS11365	COG1522	sequence-specific DNA binding
HPS44_RS11385	COG3622	Belongs to the hyi family
HPS44_RS11405	COG0583	DNA-binding transcription factor activity
HPS44_RS11410	COG2186	Transcriptional regulator
HPS44_RS11415	COG3395	kinase activity
HPS44_RS11420	COG2084	Dehydrogenase
HPS44_RS11425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS44_RS11430	COG3622	Belongs to the hyi family
HPS44_RS11435	COG0235	Class ii aldolase
HPS44_RS11505	COG0142	geranyltranstransferase activity
HPS44_RS11510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPS44_RS11515	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPS44_RS11520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPS44_RS11525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPS44_RS11540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPS44_RS11545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPS44_RS11555	COG2186	Transcriptional regulator
HPS44_RS11560	COG3447	MASE1 domain protein
HPS44_RS11560	COG5001	Diguanylate cyclase
HPS44_RS11560	COG5002	protein histidine kinase activity
HPS44_RS11565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPS44_RS11570	COG0793	Belongs to the peptidase S41A family
HPS44_RS11575	COG4942	peptidase
HPS44_RS11580	COG0588	phosphoglycerate mutase activity
HPS44_RS11590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPS44_RS11595	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HPS44_RS11600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPS44_RS11605	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS11615	COG1040	competence protein
HPS44_RS11620	COG2226	methyltransferase
HPS44_RS11625	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HPS44_RS11630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPS44_RS11635	COG0569	domain protein
HPS44_RS11640	COG2204	response regulator
HPS44_RS11645	COG5000	phosphorelay sensor kinase activity
HPS44_RS11655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPS44_RS11655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPS44_RS11660	COG1280	lysine exporter protein (LysE YggA)
HPS44_RS11665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPS44_RS11675	COG1733	regulation of RNA biosynthetic process
HPS44_RS11695	COG0546	phosphoglycolate phosphatase activity
HPS44_RS11705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPS44_RS11710	COG0242	peptide deformylase activity
HPS44_RS11715	COG0758	DNA mediated transformation
HPS44_RS11730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS11735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS11740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPS44_RS11745	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS11760	COG1238	metal cluster binding
HPS44_RS11765	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS44_RS11770	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_RS11785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPS44_RS11790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPS44_RS11795	COG4988	ABC transporter
HPS44_RS11805	COG1294	oxidase, subunit
HPS44_RS11820	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HPS44_RS11830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPS44_RS11845	COG1137	ATPase activity
HPS44_RS11850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPS44_RS11860	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HPS44_RS11865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS11880	COG1660	Displays ATPase and GTPase activities
HPS44_RS11890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS44_RS11900	COG0792	nuclease activity
HPS44_RS11905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HPS44_RS11915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_RS11920	COG1464	Belongs to the NlpA lipoprotein family
HPS44_RS11925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPS44_RS11935	COG1309	transcriptional regulator
HPS44_RS11940	COG0471	metal ion transport
HPS44_RS11945	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS44_RS11950	COG0772	Belongs to the SEDS family
HPS44_RS11955	COG0768	penicillin binding
HPS44_RS11965	COG1792	Involved in formation and maintenance of cell shape
HPS44_RS11970	COG1077	Cell shape determining protein MreB Mrl
HPS44_RS11975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPS44_RS11980	COG0154	amidase activity
HPS44_RS11985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPS44_RS12000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPS44_RS12005	COG0708	Exodeoxyribonuclease III
HPS44_RS12010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPS44_RS12020	COG0583	DNA-binding transcription factor activity
HPS44_RS12035	COG0583	DNA-binding transcription factor activity
HPS44_RS12060	COG1764	response to oxidative stress
HPS44_RS12065	COG1846	Transcriptional regulator
HPS44_RS12125	COG0640	Transcriptional regulator
HPS44_RS12155	COG3189	MarR family transcriptional regulator
HPS44_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS12180	COG0351	phosphomethylpyrimidine kinase
HPS44_RS12180	COG0352	thiamine-phosphate diphosphorylase activity
HPS44_RS12180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPS44_RS12215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HPS44_RS12220	COG0513	Belongs to the DEAD box helicase family
HPS44_RS12230	COG0617	tRNA 3'-terminal CCA addition
HPS44_RS12240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPS44_RS12245	COG2308	Evidence 4 Homologs of previously reported genes of
HPS44_RS12255	COG1305	Transglutaminase-like
HPS44_RS12275	COG1950	PFAM Membrane protein of
HPS44_RS12280	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HPS44_RS12285	COG0438	transferase activity, transferring glycosyl groups
HPS44_RS12300	COG0066	3-isopropylmalate dehydratase activity
HPS44_RS12315	COG0583	DNA-binding transcription factor activity
HPS44_RS12320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPS44_RS12360	COG0477	Major facilitator Superfamily
HPS44_RS12365	COG0154	amidase activity
HPS44_RS12370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPS44_RS12385	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPS44_RS12395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HPS44_RS12400	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HPS44_RS12410	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPS44_RS12425	COG0735	belongs to the Fur family
HPS44_RS12430	COG0523	cobalamin synthesis protein
HPS44_RS12440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HPS44_RS12445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HPS44_RS12455	COG2096	Adenosyltransferase
HPS44_RS12460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPS44_RS12475	COG0321	lipoyl(octanoyl) transferase activity
HPS44_RS12480	COG2921	Belongs to the UPF0250 family
HPS44_RS12490	COG1686	Belongs to the peptidase S11 family
HPS44_RS12515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPS44_RS12525	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HPS44_RS12540	COG0859	PFAM glycosyl transferase family 9
HPS44_RS12565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPS44_RS12595	COG0438	transferase activity, transferring glycosyl groups
HPS44_RS12605	COG0367	asparagine synthase
HPS44_RS12625	COG1088	dTDP-glucose 4,6-dehydratase activity
HPS44_RS12630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPS44_RS12640	COG0367	asparagine synthase
HPS44_RS12675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPS44_RS12695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPS44_RS12715	COG0367	asparagine synthase
HPS44_RS12720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPS44_RS12735	COG2814	Major facilitator Superfamily
HPS44_RS12765	COG3568	Endonuclease Exonuclease Phosphatase
HPS44_RS12770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPS44_RS12795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS44_RS12810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_RS12815	COG1956	GAF domain-containing protein
HPS44_RS12820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS12845	COG2186	Transcriptional regulator
HPS44_RS12850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPS44_RS12880	COG4106	trans-aconitate 2-methyltransferase activity
HPS44_RS12890	COG2814	Major facilitator Superfamily
HPS44_RS12900	COG0625	glutathione transferase activity
HPS44_RS12905	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HPS44_RS12910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPS44_RS12915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPS44_RS12925	COG1965	Belongs to the frataxin family
HPS44_RS12935	COG0019	diaminopimelate decarboxylase activity
HPS44_RS12940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPS44_RS12945	COG1333	cytochrome c biogenesis protein
HPS44_RS12955	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HPS44_RS12970	COG4232	protein-disulfide reductase activity
HPS44_RS12975	COG1324	tolerance protein
HPS44_RS12985	COG0203	ribosomal protein L17
HPS44_RS12990	COG0202	RNA polymerase activity
HPS44_RS12995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPS44_RS13000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPS44_RS13005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPS44_RS13010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPS44_RS13015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPS44_RS13020	COG0201	protein transport
HPS44_RS13025	COG0200	Binds to the 23S rRNA
HPS44_RS13030	COG1841	ribosomal large subunit assembly
HPS44_RS13035	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPS44_RS13040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPS44_RS13045	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPS44_RS13050	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPS44_RS13055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPS44_RS13060	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPS44_RS13065	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPS44_RS13070	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPS44_RS13085	COG2169	Transcriptional regulator
HPS44_RS13085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS44_RS13100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS44_RS13120	COG4177	L-phenylalanine transmembrane transporter activity
HPS44_RS13135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPS44_RS13140	COG0255	Belongs to the universal ribosomal protein uL29 family
HPS44_RS13145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPS44_RS13150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPS44_RS13155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPS44_RS13160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPS44_RS13165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPS44_RS13170	COG0089	rRNA binding
HPS44_RS13180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPS44_RS13185	COG0051	transcription antitermination factor activity, RNA binding
HPS44_RS13190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPS44_RS13195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPS44_RS13200	COG0049	tRNA binding
HPS44_RS13205	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HPS44_RS13210	COG0745	RESPONSE REGULATOR receiver
HPS44_RS13225	COG5002	protein histidine kinase activity
HPS44_RS13240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPS44_RS13245	COG0085	RNA polymerase activity
HPS44_RS13250	COG0222	ribosome binding
HPS44_RS13255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPS44_RS13260	COG0081	regulation of translation
HPS44_RS13265	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPS44_RS13275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPS44_RS13285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPS44_RS13325	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS44_RS13330	COG3842	ATPase activity
HPS44_RS13340	COG1349	DNA-binding transcription factor activity
HPS44_RS13365	COG0583	DNA-binding transcription factor activity
HPS44_RS13370	COG0252	asparaginase activity
HPS44_RS13375	COG1475	DNA binding
HPS44_RS13385	COG1192	Involved in chromosome partitioning
HPS44_RS13390	COG0357	Ribosomal RNA small subunit methyltransferase G
HPS44_RS13395	COG0445	tRNA wobble uridine modification
HPS44_RS13400	COG1278	Cold shock
HPS44_RS13405	COG3180	Ammonia monooxygenase
HPS44_RS13410	COG0436	Aminotransferase
HPS44_RS13440	COG0038	chloride channel
HPS44_RS13450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPS44_RS13460	COG0601	transmembrane transport
HPS44_RS13465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_RS13470	COG0444	Belongs to the ABC transporter superfamily
HPS44_RS13475	COG4608	Belongs to the ABC transporter superfamily
HPS44_RS13480	COG1473	amidohydrolase
HPS44_RS13485	COG2175	clavaminate synthase activity
HPS44_RS13495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPS44_RS13500	COG0753	catalase activity
HPS44_RS13510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HPS44_RS13515	COG0594	ribonuclease P activity
HPS44_RS13520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPS44_RS13525	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPS44_RS13530	COG0592	DNA-directed DNA polymerase activity
HPS44_RS13540	COG0583	DNA-binding transcription factor activity
HPS44_RS13565	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HPS44_RS13575	COG0583	DNA-binding transcription factor activity
HPS44_RS13580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS13585	COG0765	amino acid transport
HPS44_RS13590	COG0765	amino acid transport
HPS44_RS13595	COG1126	abc transporter atp-binding protein
HPS44_RS13635	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS44_RS13640	COG1177	transmembrane transport
HPS44_RS13695	COG1609	Transcriptional regulator
HPS44_RS13705	COG3842	ATPase activity
HPS44_RS13710	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS44_RS13715	COG1177	transmembrane transport
HPS44_RS13740	COG0251	oxidation-reduction process
HPS44_RS13780	COG0402	S-adenosylhomocysteine deaminase activity
HPS44_RS13800	COG1744	ABC transporter substrate-binding protein PnrA-like
HPS44_RS13810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPS44_RS13825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPS44_RS13840	COG2814	Major facilitator Superfamily
HPS44_RS13855	COG3781	membrane
HPS44_RS13860	COG1522	sequence-specific DNA binding
HPS44_RS13865	COG0028	Belongs to the TPP enzyme family
HPS44_RS13870	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS13875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS13900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS44_RS13905	COG2922	Belongs to the Smg family
HPS44_RS13915	COG2358	TRAP transporter, solute receptor (TAXI family
HPS44_RS13935	COG0765	amino acid transport
HPS44_RS13940	COG0765	amino acid transport
HPS44_RS13945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS13950	COG3422	double-strand break repair
HPS44_RS13955	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS13960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPS44_RS14005	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPS44_RS14025	COG3339	Conserved Protein
HPS44_RS14060	COG2186	Transcriptional regulator
HPS44_RS14065	COG2814	Major facilitator Superfamily
HPS44_RS14080	COG1595	DNA-templated transcription, initiation
HPS44_RS14085	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS14100	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS14110	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS14145	COG2207	Transcriptional regulator
HPS44_RS14165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HPS44_RS14170	COG0183	Belongs to the thiolase family
HPS44_RS14175	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HPS44_RS14180	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS14185	COG1473	amidohydrolase
HPS44_RS14195	COG1742	UPF0060 membrane protein
HPS44_RS14210	COG1280	lysine exporter protein (LysE YggA)
HPS44_RS14245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS44_RS14255	COG0018	arginyl-trna synthetase
HPS44_RS14270	COG0395	ABC-type sugar transport system, permease component
HPS44_RS14275	COG1175	transmembrane transport
HPS44_RS14280	COG1653	transport
HPS44_RS14285	COG3842	ATPase activity
HPS44_RS14290	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS44_RS14295	COG1609	Transcriptional regulator
HPS44_RS14305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPS44_RS14320	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPS44_RS14340	COG0583	DNA-binding transcription factor activity
HPS44_RS14360	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HPS44_RS14365	COG1280	lysine exporter protein (LysE YggA)
HPS44_RS14370	COG0513	Belongs to the DEAD box helicase family
HPS44_RS14375	COG5339	Protein conserved in bacteria
HPS44_RS14380	COG5339	Protein conserved in bacteria
HPS44_RS14385	COG1228	amidohydrolase
HPS44_RS14395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_RS14405	COG0747	negative chemotaxis
HPS44_RS14410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPS44_RS14420	COG3708	Transcriptional regulator
HPS44_RS14420	COG2207	Transcriptional regulator
HPS44_RS14430	COG1104	cysteine desulfurase activity
HPS44_RS14440	COG0583	DNA-binding transcription factor activity
HPS44_RS14470	COG2969	positive regulation of protein catabolic process
HPS44_RS14475	COG0625	glutathione transferase activity
HPS44_RS14480	COG2857	Cytochrome c1
HPS44_RS14485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPS44_RS14490	COG0723	plastoquinol--plastocyanin reductase activity
HPS44_RS14495	COG1970	mechanosensitive ion channel activity
HPS44_RS14500	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPS44_RS14505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS44_RS14520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPS44_RS14525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPS44_RS14530	COG0537	adenosine 5'-monophosphoramidase activity
HPS44_RS14535	COG0140	phosphoribosyl-ATP diphosphatase activity
HPS44_RS14545	COG0107	imidazoleglycerol-phosphate synthase activity
HPS44_RS14550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPS44_RS14555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPS44_RS14560	COG0131	Imidazoleglycerol-phosphate dehydratase
HPS44_RS14565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS44_RS14570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPS44_RS14575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPS44_RS14580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPS44_RS14590	COG0842	Transport permease protein
HPS44_RS14595	COG1131	(ABC) transporter
HPS44_RS14605	COG2853	Lipoprotein
HPS44_RS14610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPS44_RS14615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPS44_RS14620	COG1127	ABC transporter
HPS44_RS14625	COG2070	2-Nitropropane dioxygenase
HPS44_RS14635	COG0477	Major facilitator Superfamily
HPS44_RS14650	COG0583	DNA-binding transcription factor activity
HPS44_RS14655	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HPS44_RS14660	COG0511	ligase activity, forming carbon-carbon bonds
HPS44_RS14675	COG1984	allophanate hydrolase subunit 2
HPS44_RS14690	COG0067	glutamate synthase
HPS44_RS14690	COG0069	glutamate synthase activity
HPS44_RS14690	COG0070	glutamate synthase
HPS44_RS14715	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS44_RS14735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPS44_RS14765	COG1612	heme a metabolic process
HPS44_RS14775	COG1999	signal sequence binding
HPS44_RS14795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPS44_RS14800	COG2814	Major facilitator Superfamily
HPS44_RS14810	COG0438	transferase activity, transferring glycosyl groups
HPS44_RS14830	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HPS44_RS14835	COG1959	2 iron, 2 sulfur cluster binding
HPS44_RS14840	COG2814	Major facilitator Superfamily
HPS44_RS14855	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HPS44_RS14880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPS44_RS14885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPS44_RS14890	COG2814	Major facilitator Superfamily
HPS44_RS14895	COG0583	DNA-binding transcription factor activity
HPS44_RS14905	COG2423	ornithine cyclodeaminase activity
HPS44_RS14910	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HPS44_RS14915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPS44_RS14925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPS44_RS14935	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPS44_RS14940	COG0463	Glycosyl transferase, family 2
HPS44_RS14990	COG0737	Belongs to the 5'-nucleotidase family
HPS44_RS15005	COG2188	Transcriptional regulator
HPS44_RS15015	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPS44_RS15020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPS44_RS15035	COG0840	transmembrane signaling receptor activity
HPS44_RS15040	COG2814	Major facilitator Superfamily
HPS44_RS15090	COG1802	Transcriptional regulator
HPS44_RS15100	COG3069	C4-dicarboxylate transmembrane transporter activity
HPS44_RS15105	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_RS15130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_RS15140	COG0747	negative chemotaxis
HPS44_RS15165	COG1464	Belongs to the NlpA lipoprotein family
HPS44_RS15170	COG0431	NADPH-dependent FMN reductase
HPS44_RS15175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_RS15180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS44_RS15185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS15200	COG2011	ABC-type metal ion transport system permease component
HPS44_RS15205	COG1464	Belongs to the NlpA lipoprotein family
HPS44_RS15210	COG1116	anion transmembrane transporter activity
HPS44_RS15215	COG3585	molybdate ion transport
HPS44_RS15220	COG3064	Membrane
HPS44_RS15245	COG1607	acyl-coa hydrolase
HPS44_RS15260	COG0437	4 iron, 4 sulfur cluster binding
HPS44_RS15265	COG2864	formate dehydrogenase
HPS44_RS15280	COG3276	selenocysteine insertion sequence binding
HPS44_RS15290	COG1216	Glycosyl transferase, family 2
HPS44_RS15295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_RS15300	COG1305	Transglutaminase-like
HPS44_RS15305	COG0709	Synthesizes selenophosphate from selenide and ATP
HPS44_RS15335	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_RS15340	COG3284	Transcriptional regulator
HPS44_RS15345	COG0134	indole-3-glycerol-phosphate synthase activity
HPS44_RS15350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPS44_RS15355	COG0512	Glutamine amidotransferase of anthranilate synthase
HPS44_RS15365	COG0546	phosphoglycolate phosphatase activity
HPS44_RS15370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPS44_RS15375	COG2967	ApaG domain
HPS44_RS15385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS44_RS15390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS44_RS15400	COG0037	tRNA processing
HPS44_RS15415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS44_RS15430	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_RS15435	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_RS15450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS44_RS15475	COG3473	Maleate cis-trans isomerase
HPS44_RS15480	COG0583	DNA-binding transcription factor activity
HPS44_RS15495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPS44_RS15505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS44_RS15510	COG1024	Enoyl-CoA hydratase
HPS44_RS15525	COG0356	it plays a direct role in the translocation of protons across the membrane
HPS44_RS15540	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPS44_RS15545	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPS44_RS15550	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPS44_RS15560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPS44_RS15570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPS44_RS15575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPS44_RS15580	COG0210	DNA helicase
HPS44_RS15595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPS44_RS15610	COG2171	N-acyltransferase activity
HPS44_RS15620	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPS44_RS15630	COG4608	Belongs to the ABC transporter superfamily
HPS44_RS15635	COG0444	Belongs to the ABC transporter superfamily
HPS44_RS15645	COG0601	transmembrane transport
HPS44_RS15650	COG0747	negative chemotaxis
HPS44_RS15655	COG2988	succinylglutamate desuccinylase activity
HPS44_RS15665	COG0583	DNA-binding transcription factor activity
HPS44_RS15670	COG0747	negative chemotaxis
HPS44_RS15680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPS44_RS15685	COG1024	Enoyl-CoA hydratase
HPS44_RS15690	COG1024	Enoyl-CoA hydratase
HPS44_RS15700	COG1309	transcriptional regulator
HPS44_RS15715	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_RS15730	COG2814	Major facilitator Superfamily
HPS44_RS15745	COG1764	response to oxidative stress
HPS44_RS15750	COG0583	DNA-binding transcription factor activity
HPS44_RS15760	COG1595	DNA-templated transcription, initiation
HPS44_RS15765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPS44_RS15770	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_RS15785	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS44_RS15805	COG1129	ABC transporter
HPS44_RS15820	COG1802	Transcriptional regulator
HPS44_RS15830	COG0583	DNA-binding transcription factor activity
HPS44_RS15840	COG2988	succinylglutamate desuccinylase activity
HPS44_RS15850	COG2918	glutathione biosynthetic process
HPS44_RS15880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPS44_RS15885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS44_RS15895	COG2721	sulfolactate sulfo-lyase activity
HPS44_RS15900	COG2721	sulfolactate sulfo-lyase activity
HPS44_RS15905	COG2188	Transcriptional regulator
HPS44_RS15910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS44_RS15915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPS44_RS15915	COG2813	Specifically methylates the guanine in position
HPS44_RS15920	COG2223	nitrite transmembrane transporter activity
HPS44_RS15930	COG2860	membrane
HPS44_RS15935	COG1802	Transcriptional regulator
HPS44_RS15945	COG1984	allophanate hydrolase subunit 2
HPS44_RS15950	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPS44_RS15960	COG0583	DNA-binding transcription factor activity
HPS44_RS15975	COG4774	siderophore transport
HPS44_RS15980	COG3712	iron ion homeostasis
HPS44_RS15990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS44_RS16005	COG2132	Multicopper oxidase
HPS44_RS16030	COG0745	RESPONSE REGULATOR receiver
HPS44_RS16035	COG2226	methyltransferase
HPS44_RS16050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPS44_RS16060	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPS44_RS16070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HPS44_RS16075	COG0351	phosphomethylpyrimidine kinase
HPS44_RS16080	COG2022	thiamine diphosphate biosynthetic process
HPS44_RS16085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPS44_RS16090	COG4771	TonB-dependent receptor
HPS44_RS16100	COG2186	Transcriptional regulator
HPS44_RS16115	COG1063	alcohol dehydrogenase
HPS44_RS16125	COG0765	amino acid transport
HPS44_RS16130	COG1126	abc transporter atp-binding protein
HPS44_RS16135	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_RS16140	COG0246	Mannitol dehydrogenase
HPS44_RS16160	COG1194	a g-specific adenine glycosylase
HPS44_RS16180	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HPS44_RS16185	COG2177	Part of the ABC transporter FtsEX involved in
HPS44_RS16190	COG2884	Cell division ATP-binding protein ftsE
HPS44_RS16195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS16200	COG4597	amino acid ABC transporter
HPS44_RS16205	COG0765	amino acid transport
HPS44_RS16210	COG1126	abc transporter atp-binding protein
HPS44_RS16235	COG1129	ABC transporter
HPS44_RS16240	COG4177	L-phenylalanine transmembrane transporter activity
HPS44_RS16255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS44_RS16260	COG2081	HI0933 family
HPS44_RS16270	COG0077	Prephenate dehydratase
HPS44_RS16270	COG1605	Chorismate mutase
HPS44_RS16305	COG0477	Major facilitator Superfamily
HPS44_RS16315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HPS44_RS16320	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPS44_RS16340	COG0237	dephospho-CoA kinase activity
HPS44_RS16345	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HPS44_RS16375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_RS16380	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS44_RS16395	COG3833	ABC-type maltose transport systems, permease component
HPS44_RS16400	COG1175	transmembrane transport
HPS44_RS16405	COG3842	ATPase activity
HPS44_RS16425	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPS44_RS16460	COG0410	ABC transporter
HPS44_RS16480	COG3706	GGDEF domain
HPS44_RS16500	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS16505	COG1024	Enoyl-CoA hydratase
HPS44_RS16545	COG4638	Rieske (2fe-2S)
HPS44_RS16550	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS44_RS16555	COG1335	isochorismatase
HPS44_RS16560	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS16570	COG0741	lytic transglycosylase activity
HPS44_RS16575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPS44_RS16580	COG0352	thiamine-phosphate diphosphorylase activity
HPS44_RS16595	COG1678	Uncharacterized ACR, COG1678
HPS44_RS16600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPS44_RS16610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPS44_RS16630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS44_RS16635	COG0436	Aminotransferase
HPS44_RS16640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS16650	COG0765	amino acid transport
HPS44_RS16655	COG1126	abc transporter atp-binding protein
HPS44_RS16665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS44_RS16675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPS44_RS16680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPS44_RS16690	COG3842	ATPase activity
HPS44_RS16695	COG1175	transmembrane transport
HPS44_RS16705	COG0642	Histidine kinase
HPS44_RS16715	COG0557	exoribonuclease II activity
HPS44_RS16720	COG3150	esterase
HPS44_RS16725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPS44_RS16730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_RS16735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPS44_RS16740	COG0511	ligase activity, forming carbon-carbon bonds
HPS44_RS16745	COG0439	Biotin carboxylase
HPS44_RS16750	COG2264	protein methyltransferase activity
HPS44_RS16760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPS44_RS16760	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPS44_RS16785	COG1696	Membrane protein involved in D-alanine export
HPS44_RS16820	COG1522	sequence-specific DNA binding
HPS44_RS16825	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS16835	COG0583	DNA-binding transcription factor activity
HPS44_RS16850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS44_RS16855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPS44_RS16855	COG1042	CoA-binding domain protein
HPS44_RS16855	COG0045	succinate-CoA ligase (ADP-forming) activity
HPS44_RS16860	COG1335	isochorismatase
HPS44_RS16865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS16870	COG1116	anion transmembrane transporter activity
HPS44_RS16885	COG3028	Belongs to the UPF0307 family
HPS44_RS16890	COG0312	modulator of DNA gyrase
HPS44_RS16895	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS44_RS16905	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_RS16910	COG4177	L-phenylalanine transmembrane transporter activity
HPS44_RS16925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPS44_RS16930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPS44_RS16935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPS44_RS16945	COG0316	Belongs to the HesB IscA family
HPS44_RS16960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPS44_RS16970	COG1280	lysine exporter protein (LysE YggA)
HPS44_RS16975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPS44_RS16980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPS44_RS16990	COG1335	isochorismatase
HPS44_RS16995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPS44_RS16995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPS44_RS17010	COG2766	serine protein kinase
HPS44_RS17015	COG2718	Belongs to the UPF0229 family
HPS44_RS17020	COG2719	SpoVR family
HPS44_RS17030	COG0583	DNA-binding transcription factor activity
HPS44_RS17035	COG1942	4-Oxalocrotonate Tautomerase
HPS44_RS17045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPS44_RS17055	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS17100	COG4789	Type iii secretion
HPS44_RS17205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPS44_RS17210	COG4790	Type iii secretion
HPS44_RS17215	COG4794	Type iii secretion
HPS44_RS17220	COG4791	protein targeting
HPS44_RS17225	COG4792	protein secretion
HPS44_RS17255	COG2770	Histidine kinase
HPS44_RS17255	COG2208	phosphoserine phosphatase activity
HPS44_RS17265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPS44_RS17270	COG2172	sigma factor antagonist activity
HPS44_RS17275	COG1366	Belongs to the anti-sigma-factor antagonist family
HPS44_RS17315	COG1388	LysM domain
HPS44_RS17315	COG0741	lytic transglycosylase activity
HPS44_RS17320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPS44_RS17325	COG2226	methyltransferase
HPS44_RS17330	COG0328	RNA-DNA hybrid ribonuclease activity
HPS44_RS17340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS44_RS17345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPS44_RS17360	COG1671	Belongs to the UPF0178 family
HPS44_RS17375	COG0786	glutamate:sodium symporter activity
HPS44_RS17385	COG0463	Glycosyl transferase, family 2
HPS44_RS17390	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPS44_RS17405	COG0583	DNA-binding transcription factor activity
HPS44_RS17425	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_RS17445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_RS17455	COG0583	DNA-binding transcription factor activity
HPS44_RS17465	COG1346	cytolysis
HPS44_RS17475	COG0697	spore germination
HPS44_RS17480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS17495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPS44_RS17505	COG1522	sequence-specific DNA binding
HPS44_RS17520	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HPS44_RS17525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_RS17540	COG0823	Involved in the tonB-independent uptake of proteins
HPS44_RS17550	COG0848	biopolymer transport protein
HPS44_RS17555	COG0811	peptide transport
HPS44_RS17560	COG0824	Thioesterase
HPS44_RS17565	COG0442	prolyl-tRNA aminoacylation
HPS44_RS17595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS44_RS17610	COG2084	Dehydrogenase
HPS44_RS17615	COG0405	Gamma-glutamyltransferase
HPS44_RS17655	COG0129	dihydroxy-acid dehydratase activity
HPS44_RS17660	COG4654	Cytochrome c, class I
HPS44_RS17665	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS44_RS17675	COG1522	sequence-specific DNA binding
HPS44_RS17715	COG0583	DNA-binding transcription factor activity
HPS44_RS17725	COG1473	amidohydrolase
HPS44_RS17730	COG0418	dihydroorotase activity
HPS44_RS17745	COG2001	Belongs to the MraZ family
HPS44_RS17750	COG0275	rRNA processing
HPS44_RS17755	COG3116	cell division
HPS44_RS17765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS44_RS17770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPS44_RS17775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPS44_RS17785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPS44_RS17790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPS44_RS17795	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPS44_RS17800	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPS44_RS17810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPS44_RS17815	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPS44_RS17825	COG0739	heme binding
HPS44_RS17830	COG0653	protein targeting
HPS44_RS17845	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS17850	COG0028	Belongs to the TPP enzyme family
HPS44_RS17860	COG0300	oxidoreductase activity
HPS44_RS17865	COG1522	sequence-specific DNA binding
HPS44_RS17880	COG2239	Acts as a magnesium transporter
HPS44_RS17890	COG2855	membrane
HPS44_RS17895	COG0583	DNA-binding transcription factor activity
HPS44_RS17900	COG1473	amidohydrolase
HPS44_RS17905	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS17910	COG0483	inositol monophosphate 1-phosphatase activity
HPS44_RS17915	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HPS44_RS17915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_RS17920	COG1501	Belongs to the glycosyl hydrolase 31 family
HPS44_RS17925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPS44_RS17930	COG2011	ABC-type metal ion transport system permease component
HPS44_RS17990	COG0840	transmembrane signaling receptor activity
HPS44_RS17995	COG0583	DNA-binding transcription factor activity
HPS44_RS18005	COG0735	belongs to the Fur family
HPS44_RS18030	COG2818	Glycosylase
HPS44_RS18035	COG1368	sulfuric ester hydrolase activity
HPS44_RS18040	COG2982	Protein involved in outer membrane biogenesis
HPS44_RS18055	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS18085	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPS44_RS18115	COG3178	'Phosphotransferase
HPS44_RS18125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_RS18130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPS44_RS18135	COG1929	Belongs to the glycerate kinase type-1 family
HPS44_RS18140	COG0469	pyruvate kinase activity
HPS44_RS18145	COG0700	Nucleoside recognition
HPS44_RS18150	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS18155	COG0242	peptide deformylase activity
HPS44_RS18165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HPS44_RS18175	COG0204	Acyl-transferase
HPS44_RS18180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPS44_RS18185	COG0751	glycine-tRNA ligase activity
HPS44_RS18190	COG0752	glycyl-tRNA synthetase alpha subunit
HPS44_RS18195	COG1024	Enoyl-CoA hydratase
HPS44_RS18215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_RS18220	COG2030	dehydratase
HPS44_RS18225	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS18245	COG2070	2-Nitropropane dioxygenase
HPS44_RS18255	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS18260	COG0183	Belongs to the thiolase family
HPS44_RS18270	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS18275	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS18280	COG1024	Enoyl-CoA hydratase
HPS44_RS18290	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HPS44_RS18300	COG2301	Belongs to the HpcH HpaI aldolase family
HPS44_RS18305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPS44_RS18315	COG0617	tRNA 3'-terminal CCA addition
HPS44_RS18330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPS44_RS18340	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPS44_RS18345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPS44_RS18350	COG0586	Pfam SNARE associated Golgi protein
HPS44_RS18360	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPS44_RS18365	COG0802	atpase or kinase
HPS44_RS18370	COG0114	fumarate hydratase activity
HPS44_RS18380	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS18395	COG0531	amino acid
HPS44_RS18400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_RS18405	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS18410	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS18415	COG0583	DNA-binding transcription factor activity
HPS44_RS18420	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS44_RS18440	COG2175	clavaminate synthase activity
HPS44_RS18450	COG0583	DNA-binding transcription factor activity
HPS44_RS18460	COG0579	oxidoreductase
HPS44_RS18470	COG0259	pyridoxamine-phosphate oxidase activity
HPS44_RS18485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_RS18490	COG1136	(ABC) transporter
HPS44_RS18490	COG0577	efflux transmembrane transporter activity
HPS44_RS18495	COG1538	Outer membrane efflux protein
HPS44_RS18500	COG0583	DNA-binding transcription factor activity
HPS44_RS18515	COG0577	efflux transmembrane transporter activity
HPS44_RS18515	COG1136	(ABC) transporter
HPS44_RS18550	COG0577	efflux transmembrane transporter activity
HPS44_RS18550	COG1136	(ABC) transporter
HPS44_RS18555	COG1136	(ABC) transporter
HPS44_RS18555	COG0577	efflux transmembrane transporter activity
HPS44_RS18565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_RS18570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPS44_RS18605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPS44_RS18615	COG0800	Aldolase
HPS44_RS18630	COG0463	Glycosyl transferase, family 2
HPS44_RS18630	COG1216	Glycosyl transferase, family 2
HPS44_RS18655	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS18660	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HPS44_RS18680	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS44_RS18685	COG4638	Rieske (2fe-2S)
HPS44_RS18710	COG0747	negative chemotaxis
HPS44_RS18720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_RS18725	COG0444	Belongs to the ABC transporter superfamily
HPS44_RS18730	COG4608	Belongs to the ABC transporter superfamily
HPS44_RS18750	COG2746	aminoglycoside 3-N-acetyltransferase activity
HPS44_RS18755	COG0488	(ABC) transporter
HPS44_RS18780	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPS44_RS18785	COG2894	cell division
HPS44_RS18790	COG0850	regulation of cytokinetic process
HPS44_RS18795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPS44_RS18805	COG1294	oxidase, subunit
HPS44_RS18810	COG0514	ATP-dependent DNA helicase (RecQ)
HPS44_RS18820	COG0745	RESPONSE REGULATOR receiver
HPS44_RS18825	COG4191	Histidine kinase
HPS44_RS18830	COG2255	four-way junction helicase activity
HPS44_RS18840	COG1090	epimerase
HPS44_RS18845	COG0632	four-way junction helicase activity
HPS44_RS18850	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPS44_RS18870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPS44_RS18880	COG0006	proline dipeptidase activity
HPS44_RS18895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPS44_RS18900	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_RS18915	COG4783	chaperone-mediated protein folding
HPS44_RS18955	COG2814	Major facilitator Superfamily
HPS44_RS18960	COG4771	TonB-dependent receptor
HPS44_RS18970	COG0513	Belongs to the DEAD box helicase family
HPS44_RS18985	COG1058	Belongs to the CinA family
HPS44_RS18985	COG1546	Belongs to the CinA family
HPS44_RS18990	COG1414	Transcriptional regulator
HPS44_RS19005	COG0167	dihydroorotate dehydrogenase activity
HPS44_RS19010	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HPS44_RS19015	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPS44_RS19105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS44_RS19110	COG0735	belongs to the Fur family
HPS44_RS19115	COG0497	DNA recombination
HPS44_RS19125	COG1420	regulation of RNA biosynthetic process
HPS44_RS19130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPS44_RS19140	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPS44_RS19150	COG0443	Heat shock 70 kDa protein
HPS44_RS19155	COG0484	heat shock protein binding
HPS44_RS19165	COG0612	Peptidase, M16
HPS44_RS19190	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPS44_RS19225	COG0840	transmembrane signaling receptor activity
HPS44_RS19230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_RS19245	COG0745	RESPONSE REGULATOR receiver
HPS44_RS19250	COG2205	protein histidine kinase activity
HPS44_RS19255	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HPS44_RS19260	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HPS44_RS19265	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HPS44_RS19280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPS44_RS19290	COG1193	negative regulation of DNA recombination
HPS44_RS19295	COG0492	ferredoxin-NADP+ reductase activity
HPS44_RS19300	COG1674	ftsk spoiiie
HPS44_RS19305	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HPS44_RS19310	COG0251	oxidation-reduction process
HPS44_RS19315	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS44_RS19320	COG0517	IMP dehydrogenase activity
HPS44_RS19320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPS44_RS19340	COG0601	transmembrane transport
HPS44_RS19355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS44_RS19360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPS44_RS19365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPS44_RS19410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_RS19420	COG4774	siderophore transport
HPS44_RS19425	COG4607	ABC-type enterochelin transport system periplasmic component
HPS44_RS19430	COG4604	ABC transporter, ATP-binding protein
HPS44_RS19435	COG4605	iron ion homeostasis
HPS44_RS19440	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_RS19470	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS19475	COG3022	response to hydroperoxide
HPS44_RS19480	COG1289	transmembrane transporter activity
HPS44_RS19485	COG0028	Belongs to the TPP enzyme family
HPS44_RS19490	COG0440	acetolactate synthase activity
HPS44_RS19495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPS44_RS19500	COG1183	phosphatidylcholine synthase activity
HPS44_RS19510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPS44_RS19515	COG1185	polyribonucleotide nucleotidyltransferase activity
HPS44_RS19525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS44_RS19535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPS44_RS19545	COG2207	Transcriptional regulator
HPS44_RS19570	COG0149	triose-phosphate isomerase activity
HPS44_RS19575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPS44_RS19590	COG2885	chlorophyll binding
HPS44_RS19590	COG3047	cAMP biosynthetic process
HPS44_RS19615	COG0840	transmembrane signaling receptor activity
HPS44_RS19635	COG1910	domain protein
HPS44_RS19655	COG1595	DNA-templated transcription, initiation
HPS44_RS19660	COG3712	iron ion homeostasis
HPS44_RS19675	COG1595	DNA-templated transcription, initiation
HPS44_RS19695	COG0642	Histidine kinase
HPS44_RS19705	COG2851	Citrate transporter
HPS44_RS19710	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS19730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPS44_RS19735	COG0784	Response regulator, receiver
HPS44_RS19735	COG4191	Histidine kinase
HPS44_RS19750	COG3604	Transcriptional regulator
HPS44_RS19755	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HPS44_RS19760	COG3813	Protein conserved in bacteria
HPS44_RS19765	COG2354	Protein conserved in bacteria
HPS44_RS19770	COG4772	TonB-dependent receptor
HPS44_RS19775	COG1522	sequence-specific DNA binding
HPS44_RS19795	COG4172	Belongs to the ABC transporter superfamily
HPS44_RS19805	COG0747	negative chemotaxis
HPS44_RS19825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS44_RS19840	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPS44_RS19845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_RS19850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS44_RS19870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPS44_RS19880	COG1309	transcriptional regulator
HPS44_RS19885	COG0583	DNA-binding transcription factor activity
HPS44_RS19905	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS44_RS19930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_RS19935	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS44_RS19940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS44_RS19945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS44_RS19950	COG0649	NAD binding
HPS44_RS19955	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HPS44_RS19965	COG1034	ATP synthesis coupled electron transport
HPS44_RS19970	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HPS44_RS19975	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPS44_RS19985	COG0713	ATP synthesis coupled electron transport
HPS44_RS20000	COG1007	ATP synthesis coupled electron transport
HPS44_RS20010	COG4774	siderophore transport
HPS44_RS20015	COG0560	Phosphoserine phosphatase
HPS44_RS20020	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPS44_RS20025	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPS44_RS20030	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPS44_RS20040	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPS44_RS20045	COG0450	alkyl hydroperoxide reductase
HPS44_RS20050	COG2205	protein histidine kinase activity
HPS44_RS20055	COG0745	RESPONSE REGULATOR receiver
HPS44_RS20060	COG1214	PFAM Peptidase M22, glycoprotease
HPS44_RS20065	COG1573	uracil-dna glycosylase
HPS44_RS20070	COG0477	Major facilitator Superfamily
HPS44_RS20075	COG1196	nuclear chromosome segregation
HPS44_RS20085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPS44_RS20090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_RS20100	COG2917	probably involved in intracellular septation
HPS44_RS20105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS44_RS20110	COG1122	ATPase activity
HPS44_RS20115	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPS44_RS20120	COG1268	BioY protein
HPS44_RS20155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPS44_RS20190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPS44_RS20195	COG2878	Part of a membrane complex involved in electron transport
HPS44_RS20210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPS44_RS20215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HPS44_RS20220	COG0251	oxidation-reduction process
HPS44_RS20230	COG3228	Belongs to the MtfA family
HPS44_RS20235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPS44_RS20245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS44_RS20255	COG0159	tryptophan synthase activity
HPS44_RS20260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPS44_RS20265	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HPS44_RS20270	COG1530	ribonuclease E activity
HPS44_RS20275	COG0564	pseudouridine synthase activity
HPS44_RS20280	COG0546	phosphoglycolate phosphatase activity
HPS44_RS20285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPS44_RS20290	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HPS44_RS20305	COG0424	maF-like protein
HPS44_RS20315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPS44_RS20325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS44_RS20330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPS44_RS20340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS44_RS20345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS44_RS20370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS44_RS20375	COG0481	GTPase activity
HPS44_RS20380	COG0681	Belongs to the peptidase S26 family
HPS44_RS20385	COG0571	ribonuclease III activity
HPS44_RS20390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPS44_RS20395	COG1381	Involved in DNA repair and RecF pathway recombination
HPS44_RS20445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPS44_RS20470	COG0583	DNA-binding transcription factor activity
HPS44_RS20480	COG0791	NLP P60 protein
HPS44_RS20490	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HPS44_RS20500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS44_RS20505	COG0697	spore germination
HPS44_RS20510	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPS44_RS20560	COG2153	protein acetylation
HPS44_RS20570	COG1446	asparaginase
HPS44_RS20575	COG4172	Belongs to the ABC transporter superfamily
HPS44_RS20580	COG0747	negative chemotaxis
HPS44_RS20615	COG0504	CTP synthase activity
HPS44_RS20625	COG0148	phosphopyruvate hydratase activity
HPS44_RS20640	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPS44_RS20650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS44_RS20705	COG0039	L-malate dehydrogenase activity
HPS44_RS20710	COG2188	Transcriptional regulator
HPS44_RS20715	COG2009	succinate dehydrogenase
HPS44_RS20720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPS44_RS20725	COG1053	succinate dehydrogenase
HPS44_RS20730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPS44_RS20735	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPS44_RS20740	COG0372	Belongs to the citrate synthase family
HPS44_RS20755	COG0281	malic enzyme
HPS44_RS20755	COG0280	phosphate acetyltransferase
HPS44_RS20765	COG1297	OPT oligopeptide transporter protein
HPS44_RS20770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPS44_RS20785	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HPS44_RS20790	COG1522	sequence-specific DNA binding
HPS44_RS20795	COG0567	Dehydrogenase, E1 component
HPS44_RS20800	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS44_RS20805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPS44_RS20810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPS44_RS20815	COG1595	DNA-templated transcription, initiation
HPS44_RS20820	COG3712	iron ion homeostasis
HPS44_RS20825	COG4774	siderophore transport
HPS44_RS20860	COG2183	response to ionizing radiation
HPS44_RS20865	COG1199	ATP-dependent helicase activity
HPS44_RS20875	COG0564	pseudouridine synthase activity
HPS44_RS20885	COG3243	poly(R)-hydroxyalkanoic acid synthase
HPS44_RS20890	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS20895	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HPS44_RS20920	COG2831	hemolysin activation secretion protein
HPS44_RS20950	COG2823	Periplasmic or secreted lipoprotein
HPS44_RS20960	COG3237	CsbD-like
HPS44_RS20965	COG0189	ligase activity
HPS44_RS20965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS44_RS20970	COG0189	ligase activity
HPS44_RS20970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPS44_RS20975	COG1132	(ABC) transporter
HPS44_RS20990	COG2833	Protein of unknown function (DUF455)
HPS44_RS20995	COG2258	MOSC domain
HPS44_RS21000	COG2951	lytic endotransglycosylase activity
HPS44_RS21015	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS21025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPS44_RS21035	COG1696	Membrane protein involved in D-alanine export
HPS44_RS21055	COG1215	transferase activity, transferring glycosyl groups
HPS44_RS21065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPS44_RS21090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPS44_RS21105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HPS44_RS21115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS44_RS21125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPS44_RS21130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPS44_RS21150	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPS44_RS21155	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPS44_RS21160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPS44_RS21190	COG2951	lytic endotransglycosylase activity
HPS44_RS21195	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPS44_RS21220	COG2985	domain, Protein
HPS44_RS21225	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS21230	COG0450	alkyl hydroperoxide reductase
HPS44_RS21240	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HPS44_RS21245	COG4208	sulfate ABC transporter
HPS44_RS21255	COG0175	sulfate reduction
HPS44_RS21285	COG0335	large ribosomal subunit rRNA binding
HPS44_RS21290	COG0494	nUDIX hydrolase
HPS44_RS21295	COG1162	GTPase activity
HPS44_RS21300	COG0501	Belongs to the peptidase M48B family
HPS44_RS21305	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HPS44_RS21310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPS44_RS21315	COG3327	negative regulation of DNA-templated transcription, initiation
HPS44_RS21320	COG3396	Phenylacetate-CoA oxygenase
HPS44_RS21325	COG3460	Phenylacetate-CoA oxygenase
HPS44_RS21330	COG3396	Phenylacetate-CoA oxygenase
HPS44_RS21335	COG2151	metal-sulfur cluster biosynthetic enzyme
HPS44_RS21340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPS44_RS21345	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_RS21350	COG1024	Enoyl-CoA hydratase
HPS44_RS21355	COG2050	protein possibly involved in aromatic compounds catabolism
HPS44_RS21365	COG0534	Mate efflux family protein
HPS44_RS21380	COG3483	tryptophan 2,3-dioxygenase activity
HPS44_RS21385	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HPS44_RS21390	COG2003	Belongs to the UPF0758 family
HPS44_RS21400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPS44_RS21405	COG0625	glutathione transferase activity
HPS44_RS21410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPS44_RS21435	COG0523	cobalamin synthesis protein
HPS44_RS21440	COG0523	cobalamin synthesis protein
HPS44_RS21445	COG0583	DNA-binding transcription factor activity
HPS44_RS21460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HPS44_RS21465	COG1187	pseudouridine synthase activity
HPS44_RS21470	COG0779	Required for maturation of 30S ribosomal subunits
HPS44_RS21475	COG0195	Participates in both transcription termination and antitermination
HPS44_RS21475	COG2251	uridine kinase activity
HPS44_RS21480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPS44_RS21485	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPS44_RS21490	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPS44_RS21515	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS21520	COG1473	amidohydrolase
HPS44_RS21525	COG1611	Belongs to the LOG family
HPS44_RS21540	COG0412	Dienelactone hydrolase
HPS44_RS21550	COG1760	l-serine dehydratase
HPS44_RS21555	COG0501	Belongs to the peptidase M48B family
HPS44_RS21575	COG0583	DNA-binding transcription factor activity
HPS44_RS21580	COG3842	ATPase activity
HPS44_RS21590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS44_RS21595	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS44_RS21615	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS21625	COG1722	exodeoxyribonuclease VII activity
HPS44_RS21630	COG0142	geranyltranstransferase activity
HPS44_RS21640	COG1469	GTP cyclohydrolase I activity
HPS44_RS21645	COG3739	integral membrane protein
HPS44_RS21650	COG0360	Binds together with S18 to 16S ribosomal RNA
HPS44_RS21655	COG2965	DNA replication, synthesis of RNA primer
HPS44_RS21660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPS44_RS21665	COG0359	binds to the 23S rRNA
HPS44_RS21675	COG0305	Participates in initiation and elongation during chromosome replication
HPS44_RS21685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS44_RS21720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS21770	COG0540	Belongs to the ATCase OTCase family
HPS44_RS21795	COG0642	Histidine kinase
HPS44_RS21805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPS44_RS21810	COG2137	regulation of response to DNA damage stimulus
HPS44_RS21835	COG0045	succinate-CoA ligase (ADP-forming) activity
HPS44_RS21840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPS44_RS21845	COG0861	Integral membrane protein TerC family
HPS44_RS21850	COG0861	Integral membrane protein TerC family
HPS44_RS21855	COG0181	hydroxymethylbilane synthase activity
HPS44_RS21875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPS44_RS21885	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS21915	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_RS21935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HPS44_RS21940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPS44_RS21950	COG0436	Aminotransferase
HPS44_RS21970	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HPS44_RS21975	COG0308	aminopeptidase N
HPS44_RS21990	COG0312	modulator of DNA gyrase
HPS44_RS21995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPS44_RS22000	COG0277	FAD linked oxidase domain protein
HPS44_RS22005	COG0277	FAD linked oxidase domain protein
HPS44_RS22010	COG0277	FAD linked oxidase domain protein
HPS44_RS22015	COG0247	lactate metabolic process
HPS44_RS22045	COG0583	DNA-binding transcription factor activity
HPS44_RS22050	COG0482	sulfurtransferase activity
HPS44_RS22055	COG0730	response to heat
HPS44_RS22060	COG0625	glutathione transferase activity
HPS44_RS22070	COG3909	cytochrome
HPS44_RS22110	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HPS44_RS22220	COG0697	spore germination
HPS44_RS22255	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HPS44_RS22265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPS44_RS22270	COG0069	glutamate synthase activity
HPS44_RS22280	COG2391	methyltransferase activity
HPS44_RS22285	COG0679	Auxin Efflux Carrier
HPS44_RS22315	COG0557	exoribonuclease II activity
HPS44_RS22320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPS44_RS22330	COG3128	pkhd-type hydroxylase
HPS44_RS22335	COG0776	regulation of translation
HPS44_RS22360	COG0745	RESPONSE REGULATOR receiver
HPS44_RS22365	COG0642	Histidine kinase
HPS44_RS22370	COG3158	transport of potassium into the cell
HPS44_RS22380	COG0137	argininosuccinate synthase activity
HPS44_RS22385	COG0583	DNA-binding transcription factor activity
HPS44_RS22390	COG3618	amidohydrolase
HPS44_RS22410	COG0596	Alpha beta hydrolase
HPS44_RS22410	COG2945	thiolester hydrolase activity
HPS44_RS22415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPS44_RS22420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPS44_RS22440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_RS22445	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPS44_RS22455	COG3642	lipopolysaccharide core region biosynthetic process
HPS44_RS22465	COG3842	ATPase activity
HPS44_RS22470	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPS44_RS22475	COG1177	transmembrane transport
HPS44_RS22495	COG1322	Protein conserved in bacteria
HPS44_RS22505	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS22515	COG0704	Plays a role in the regulation of phosphate uptake
HPS44_RS22525	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HPS44_RS22530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPS44_RS22530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPS44_RS22535	COG1643	Atp-dependent helicase
HPS44_RS22540	COG0395	ABC-type sugar transport system, permease component
HPS44_RS22545	COG1116	anion transmembrane transporter activity
HPS44_RS22560	COG0438	transferase activity, transferring glycosyl groups
HPS44_RS22565	COG0726	polysaccharide deacetylase
HPS44_RS22580	COG0726	polysaccharide deacetylase
HPS44_RS22605	COG1132	(ABC) transporter
HPS44_RS22610	COG0475	glutathione-regulated potassium exporter activity
HPS44_RS22610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPS44_RS22620	COG5001	Diguanylate cyclase
HPS44_RS22620	COG3706	GGDEF domain
HPS44_RS22620	COG2203	Gaf domain
HPS44_RS22620	COG4251	negative regulation of phosphorylation
HPS44_RS22630	COG1530	ribonuclease E activity
HPS44_RS22660	COG2204	response regulator
HPS44_RS22665	COG4191	Histidine kinase
HPS44_RS22670	COG1301	dicarboxylic acid transport
HPS44_RS22680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HPS44_RS22685	COG0799	negative regulation of ribosome biogenesis
HPS44_RS22690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPS44_RS22700	COG0151	Belongs to the GarS family
HPS44_RS22705	COG0217	transcriptional regulatory protein
HPS44_RS22710	COG0433	COG0433 Predicted ATPase
HPS44_RS22715	COG0473	3-isopropylmalate dehydrogenase activity
HPS44_RS22725	COG2814	Major facilitator Superfamily
HPS44_RS22730	COG1566	PFAM secretion protein HlyD family protein
HPS44_RS22740	COG1846	Transcriptional regulator
HPS44_RS22770	COG3391	amine dehydrogenase activity
HPS44_RS22780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPS44_RS22800	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPS44_RS22805	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HPS44_RS22815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPS44_RS22840	COG1309	transcriptional regulator
HPS44_RS22845	COG2311	Membrane
HPS44_RS22850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPS44_RS22875	COG0662	Cupin 2, conserved barrel domain protein
HPS44_RS22880	COG5285	phytanoyl-CoA dioxygenase
HPS44_RS22885	COG3217	Mosc domain protein beta barrel domain protein
HPS44_RS22885	COG0633	Ferredoxin
HPS44_RS22890	COG2076	Multidrug Resistance protein
HPS44_RS22905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_RS22920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPS44_RS22925	COG0425	Belongs to the sulfur carrier protein TusA family
HPS44_RS22935	COG0228	four-way junction DNA binding
HPS44_RS22945	COG0336	Belongs to the RNA methyltransferase TrmD family
HPS44_RS22950	COG1396	sequence-specific DNA binding
HPS44_RS22955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS22960	COG0765	amino acid transport
HPS44_RS22970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_RS22975	COG0525	valine-tRNA ligase activity
HPS44_RS22980	COG0105	UTP biosynthetic process
HPS44_RS22985	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPS44_RS23005	COG2976	Protein conserved in bacteria
HPS44_RS23010	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS44_RS23015	COG1160	GTP binding
HPS44_RS23020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPS44_RS23025	COG1923	regulation of RNA biosynthetic process
HPS44_RS23030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPS44_RS23035	COG0330	HflC and HflK could
HPS44_RS23040	COG0330	HflC and HflK could
HPS44_RS23045	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HPS44_RS23050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPS44_RS23055	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HPS44_RS23060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPS44_RS23080	COG0438	transferase activity, transferring glycosyl groups
HPS44_RS23120	COG4964	Belongs to the GSP D family
HPS44_RS23150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPS44_RS23160	COG1295	ribonuclease BN
HPS44_RS23170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPS44_RS23195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPS44_RS23290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPS44_RS23295	COG2274	protein secretion by the type I secretion system
HPS44_RS23305	COG1538	Outer membrane efflux protein
HPS44_RS23325	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPS44_RS23335	COG0101	tRNA pseudouridine synthase activity
HPS44_RS23340	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HPS44_RS23365	COG0596	Alpha beta hydrolase
HPS44_RS23395	COG0129	dihydroxy-acid dehydratase activity
HPS44_RS23400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_RS23405	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS44_RS23410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPS44_RS23415	COG1609	Transcriptional regulator
HPS44_RS23435	COG4172	Belongs to the ABC transporter superfamily
HPS44_RS23440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_RS23445	COG0601	transmembrane transport
HPS44_RS23455	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_RS23485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPS44_RS23490	COG2197	response regulator
HPS44_RS23500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPS44_RS23505	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPS44_RS23520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPS44_RS23525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPS44_RS23530	COG0004	ammonium transporteR
HPS44_RS23535	COG0347	Belongs to the P(II) protein family
HPS44_RS23545	COG2960	long-chain fatty acid transporting porin activity
HPS44_RS23555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPS44_RS23560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPS44_RS23565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPS44_RS23570	COG0072	phenylalanine-tRNA ligase activity
HPS44_RS23570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPS44_RS23625	COG0384	phenazine biosynthesis protein PhzF
HPS44_RS23630	COG0456	acetyltransferase
HPS44_RS23665	COG1522	sequence-specific DNA binding
HPS44_RS23695	COG0583	DNA-binding transcription factor activity
HPS44_RS23700	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS23725	COG1116	anion transmembrane transporter activity
HPS44_RS23755	COG5265	(ABC) transporter
HPS44_RS23760	COG0656	L-ascorbic acid biosynthetic process
HPS44_RS23775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPS44_RS23785	COG4977	sequence-specific DNA binding
HPS44_RS23785	COG1917	Cupin 2, conserved barrel domain protein
HPS44_RS23790	COG2223	nitrite transmembrane transporter activity
HPS44_RS23800	COG1215	transferase activity, transferring glycosyl groups
HPS44_RS23805	COG0726	polysaccharide deacetylase
HPS44_RS23805	COG1649	PFAM Uncharacterised BCR, COG1649
HPS44_RS23810	COG0457	Tetratricopeptide repeat
HPS44_RS23815	COG3706	GGDEF domain
HPS44_RS23840	COG1610	YqeY-like protein
HPS44_RS23850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS44_RS23855	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS23865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS44_RS23905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPS44_RS23915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS44_RS23920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPS44_RS23945	COG1959	2 iron, 2 sulfur cluster binding
HPS44_RS23950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_RS23955	COG0697	spore germination
HPS44_RS23960	COG0506	proline dehydrogenase activity
HPS44_RS23980	COG0583	DNA-binding transcription factor activity
HPS44_RS23985	COG2814	Major facilitator Superfamily
HPS44_RS23995	COG0583	DNA-binding transcription factor activity
HPS44_RS24000	COG0625	glutathione transferase activity
HPS44_RS24015	COG2814	Major facilitator Superfamily
HPS44_RS24020	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS44_RS24035	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS24040	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS24065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPS44_RS24080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPS44_RS24090	COG3245	cytochrome
HPS44_RS24095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPS44_RS24110	COG1280	lysine exporter protein (LysE YggA)
HPS44_RS24125	COG0697	spore germination
HPS44_RS24130	COG0697	spore germination
HPS44_RS24145	COG0534	Mate efflux family protein
HPS44_RS24150	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPS44_RS24155	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS24165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPS44_RS24170	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HPS44_RS24180	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS24215	COG2207	Transcriptional regulator
HPS44_RS24230	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS24235	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS24240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPS44_RS24245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS44_RS24255	COG1304	FMN binding
HPS44_RS24295	COG3088	subunit of a heme lyase
HPS44_RS24300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_RS24310	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPS44_RS24330	COG4133	protoheme IX ABC transporter activity
HPS44_RS24350	COG3381	protein complex oligomerization
HPS44_RS24370	COG4235	cytochrome complex assembly
HPS44_RS24380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_RS24390	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HPS44_RS24410	COG4133	protoheme IX ABC transporter activity
HPS44_RS24415	COG3005	denitrification pathway
HPS44_RS24420	COG3043	anaerobic respiration
HPS44_RS24425	COG0243	molybdopterin cofactor binding
HPS44_RS24440	COG3246	L-lysine catabolic process to acetate
HPS44_RS24445	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_RS24450	COG0583	DNA-binding transcription factor activity
HPS44_RS24460	COG0129	dihydroxy-acid dehydratase activity
HPS44_RS24465	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS24470	COG5001	Diguanylate cyclase
HPS44_RS24475	COG1024	Enoyl-CoA hydratase
HPS44_RS24520	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HPS44_RS24525	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS24530	COG0583	DNA-binding transcription factor activity
HPS44_RS24535	COG2610	gluconate transmembrane transporter activity
HPS44_RS24575	COG0235	Class ii aldolase
HPS44_RS24580	COG0477	Major facilitator Superfamily
HPS44_RS24595	COG2188	Transcriptional regulator
HPS44_RS24600	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS24640	COG1280	lysine exporter protein (LysE YggA)
HPS44_RS24645	COG5265	(ABC) transporter
HPS44_RS24655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPS44_RS24670	COG0318	PFAM AMP-dependent synthetase and ligase
HPS44_RS24675	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS24710	COG0583	DNA-binding transcription factor activity
HPS44_RS24720	COG0583	DNA-binding transcription factor activity
HPS44_RS24730	COG0583	DNA-binding transcription factor activity
HPS44_RS24760	COG2814	Major facilitator Superfamily
HPS44_RS24765	COG0154	amidase activity
HPS44_RS24815	COG2070	2-Nitropropane dioxygenase
HPS44_RS24850	COG3657	addiction module killer protein
HPS44_RS24870	COG1012	belongs to the aldehyde dehydrogenase family
HPS44_RS24875	COG0307	riboflavin synthase, alpha
HPS44_RS24885	COG2271	Major facilitator Superfamily
HPS44_RS24895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPS44_RS24905	COG0789	Transcriptional regulator
HPS44_RS24930	COG4774	siderophore transport
HPS44_RS24940	COG0022	dehydrogenase e1 component
HPS44_RS24960	COG1724	mRNA binding
HPS44_RS24965	COG1598	PFAM Uncharacterised protein family UPF0150
HPS44_RS24970	COG0165	Argininosuccinate lyase
HPS44_RS24975	COG0668	transmembrane transport
HPS44_RS25045	COG2165	general secretion pathway protein
HPS44_RS25075	COG0583	DNA-binding transcription factor activity
HPS44_RS25085	COG0747	negative chemotaxis
HPS44_RS25090	COG0601	transmembrane transport
HPS44_RS25100	COG4172	Belongs to the ABC transporter superfamily
HPS44_RS25105	COG4681	YaeQ
HPS44_RS25120	COG0477	Major facilitator Superfamily
HPS44_RS25125	COG3161	chorismate lyase activity
HPS44_RS25130	COG1187	pseudouridine synthase activity
HPS44_RS25135	COG0583	DNA-binding transcription factor activity
HPS44_RS25160	COG1999	signal sequence binding
HPS44_RS25170	COG0339	signal peptide processing
HPS44_RS25175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPS44_RS25180	COG4566	intracellular signal transduction
HPS44_RS25190	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPS44_RS25195	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPS44_RS25200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPS44_RS25210	COG0583	DNA-binding transcription factor activity
HPS44_RS25255	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HPS44_RS25270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPS44_RS25285	COG1191	sigma factor activity
HPS44_RS25305	COG1360	Flagellar Motor Protein
HPS44_RS25310	COG0745	RESPONSE REGULATOR receiver
HPS44_RS25320	COG0835	chemotaxis
HPS44_RS25325	COG0840	transmembrane signaling receptor activity
HPS44_RS25330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPS44_RS25335	COG2201	protein-glutamate methylesterase activity
HPS44_RS25340	COG0745	RESPONSE REGULATOR receiver
HPS44_RS25345	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPS44_RS25350	COG0840	transmembrane signaling receptor activity
HPS44_RS25375	COG2747	anti-sigma28 factor FlgM
HPS44_RS25385	COG1815	bacterial-type flagellum-dependent cell motility
HPS44_RS25390	COG1558	bacterial-type flagellum-dependent cell motility
HPS44_RS25405	COG4787	bacterial-type flagellum-dependent cell motility
HPS44_RS25440	COG0840	transmembrane signaling receptor activity
HPS44_RS25445	COG0840	transmembrane signaling receptor activity
HPS44_RS25455	COG0840	transmembrane signaling receptor activity
HPS44_RS25460	COG0840	transmembrane signaling receptor activity
HPS44_RS25495	COG1580	Controls the rotational direction of flagella during chemotaxis
HPS44_RS25520	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPS44_RS25525	COG1766	The M ring may be actively involved in energy transduction
HPS44_RS25530	COG1677	Flagellar hook-basal body complex protein FliE
HPS44_RS25540	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPS44_RS25560	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPS44_RS25565	COG1334	flagellar protein FlaG
HPS44_RS25570	COG1414	Transcriptional regulator
HPS44_RS25580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_RS25595	COG0285	dihydrofolate synthase activity
HPS44_RS25615	COG1451	nucleotide metabolic process
HPS44_RS25620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPS44_RS25630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HPS44_RS25635	COG0024	Methionine aminopeptidase
HPS44_RS25645	COG0052	Belongs to the universal ribosomal protein uS2 family
HPS44_RS25650	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPS44_RS25655	COG0528	UMP kinase activity
HPS44_RS25660	COG0233	cytoplasmic translational termination
HPS44_RS25665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPS44_RS25680	COG0750	zinc metalloprotease
HPS44_RS25685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPS44_RS25690	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPS44_RS25695	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPS44_RS25700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPS44_RS25715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPS44_RS25720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPS44_RS25755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPS44_RS25755	COG2169	Transcriptional regulator
HPS44_RS25760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS44_RS25760	COG0519	Catalyzes the synthesis of GMP from XMP
HPS44_RS25780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPS44_RS25785	COG2867	negative regulation of translational initiation
HPS44_RS25790	COG2914	Belongs to the UPF0125 (RnfH) family
HPS44_RS25800	COG1250	3-hydroxyacyl-CoA dehydrogenase
HPS44_RS25800	COG1024	Enoyl-CoA hydratase
HPS44_RS25825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPS44_RS25830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPS44_RS25835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPS44_RS25840	COG0084	hydrolase, TatD family'
HPS44_RS25855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS25865	COG1126	abc transporter atp-binding protein
HPS44_RS25870	COG0010	Belongs to the arginase family
HPS44_RS25880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPS44_RS25890	COG0095	Lipoate-protein ligase
HPS44_RS25905	COG0625	glutathione transferase activity
HPS44_RS25915	COG1522	sequence-specific DNA binding
HPS44_RS25920	COG0386	Belongs to the glutathione peroxidase family
HPS44_RS25925	COG2814	Major facilitator Superfamily
HPS44_RS25945	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPS44_RS25955	COG0840	transmembrane signaling receptor activity
HPS44_RS25965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPS44_RS26000	COG1902	pentaerythritol trinitrate reductase activity
HPS44_RS26030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPS44_RS26045	COG0842	Transport permease protein
HPS44_RS26050	COG1131	(ABC) transporter
HPS44_RS26065	COG2130	NADP-dependent
HPS44_RS26090	COG3842	ATPase activity
HPS44_RS26095	COG3842	ATPase activity
HPS44_RS26105	COG0395	ABC-type sugar transport system, permease component
HPS44_RS26145	COG0346	lactoylglutathione lyase activity
HPS44_RS26150	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_RS26170	COG3634	alkyl hydroperoxide reductase activity
HPS44_RS26175	COG1959	2 iron, 2 sulfur cluster binding
HPS44_RS26185	COG0583	DNA-binding transcription factor activity
HPS44_RS26190	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS26225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_RS26230	COG0420	3'-5' exonuclease activity
HPS44_RS26260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPS44_RS26260	COG2111	Na H antiporter
HPS44_RS26265	COG1006	Multisubunit Na H antiporter MnhC subunit
HPS44_RS26270	COG0651	ATP synthesis coupled electron transport
HPS44_RS26275	COG1863	multisubunit Na H antiporter MnhE subunit
HPS44_RS26280	COG2212	antiporter activity
HPS44_RS26285	COG1320	monovalent cation:proton antiporter activity
HPS44_RS26305	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPS44_RS26310	COG0488	(ABC) transporter
HPS44_RS26345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_RS26350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS44_RS26360	COG2252	PERMEase
HPS44_RS26370	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPS44_RS26405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPS44_RS26410	COG0789	Transcriptional regulator
HPS44_RS26425	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPS44_RS26425	COG0678	peroxiredoxin activity
HPS44_RS26435	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPS44_RS26440	COG0584	glycerophosphoryl diester phosphodiesterase
HPS44_RS26450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_RS26460	COG4181	ATPase activity
HPS44_RS26470	COG1178	ABC-type Fe3 transport system permease component
HPS44_RS26475	COG3842	ATPase activity
HPS44_RS26480	COG0583	DNA-binding transcription factor activity
HPS44_RS26485	COG0560	Phosphoserine phosphatase
HPS44_RS26500	COG0583	DNA-binding transcription factor activity
HPS44_RS26515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPS44_RS26530	COG0583	DNA-binding transcription factor activity
HPS44_RS26535	COG4336	lyase activity
HPS44_RS26565	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPS44_RS26585	COG2816	NAD+ diphosphatase activity
HPS44_RS26610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS26615	COG0765	amino acid transport
HPS44_RS26620	COG1126	abc transporter atp-binding protein
HPS44_RS26625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPS44_RS26630	COG1758	RNA polymerase activity
HPS44_RS26635	COG0194	GDP metabolic process
HPS44_RS26640	COG3258	Cytochrome c
HPS44_RS26645	COG2863	cytochrome
HPS44_RS26650	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS26655	COG0791	NLP P60 protein
HPS44_RS26670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPS44_RS26675	COG0833	amino acid
HPS44_RS26685	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HPS44_RS26690	COG1561	YicC-like family, N-terminal region
HPS44_RS26695	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPS44_RS26705	COG1960	acyl-CoA dehydrogenase activity
HPS44_RS26720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPS44_RS26725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPS44_RS26730	COG0174	glutamine synthetase
HPS44_RS26740	COG2204	response regulator
HPS44_RS26745	COG0583	DNA-binding transcription factor activity
HPS44_RS26750	COG1741	Belongs to the pirin family
HPS44_RS26755	COG1741	Belongs to the pirin family
HPS44_RS26760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HPS44_RS26765	COG1690	Belongs to the RtcB family
HPS44_RS26770	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS26775	COG3842	ATPase activity
HPS44_RS26780	COG4149	molybdate abc transporter
HPS44_RS26785	COG1840	ABC-type Fe3 transport system, periplasmic component
HPS44_RS26795	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS26810	COG0583	DNA-binding transcription factor activity
HPS44_RS26820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPS44_RS26830	COG0783	Belongs to the Dps family
HPS44_RS26840	COG0457	Tetratricopeptide repeat
HPS44_RS26845	COG0438	transferase activity, transferring glycosyl groups
HPS44_RS26870	COG4783	chaperone-mediated protein folding
HPS44_RS26870	COG1560	Kdo2-lipid A biosynthetic process
HPS44_RS26875	COG3866	Pectate lyase
HPS44_RS26890	COG0745	RESPONSE REGULATOR receiver
HPS44_RS26895	COG2205	protein histidine kinase activity
HPS44_RS26910	COG3842	ATPase activity
HPS44_RS26915	COG0395	ABC-type sugar transport system, permease component
HPS44_RS26920	COG1175	transmembrane transport
HPS44_RS26925	COG1653	transport
HPS44_RS26935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPS44_RS26950	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPS44_RS26975	COG1794	racemase activity, acting on amino acids and derivatives
HPS44_RS26980	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS44_RS26990	COG0583	DNA-binding transcription factor activity
HPS44_RS26995	COG0625	glutathione transferase activity
HPS44_RS27000	COG2133	pyrroloquinoline quinone binding
HPS44_RS27010	COG0697	spore germination
HPS44_RS27015	COG2363	Small membrane protein
HPS44_RS27035	COG0010	Belongs to the arginase family
HPS44_RS27045	COG1464	Belongs to the NlpA lipoprotein family
HPS44_RS27055	COG2814	Major facilitator Superfamily
HPS44_RS27065	COG1408	metallophosphoesterase
HPS44_RS27075	COG0688	phosphatidylethanolamine metabolic process
HPS44_RS27080	COG0488	(ABC) transporter
HPS44_RS27105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPS44_RS27110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPS44_RS27115	COG5001	Diguanylate cyclase
HPS44_RS27115	COG3300	MHYT domain
HPS44_RS27130	COG2814	Major facilitator Superfamily
HPS44_RS27155	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPS44_RS27160	COG2204	response regulator
HPS44_RS27195	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS27215	COG0693	protein deglycase activity
HPS44_RS27235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPS44_RS27245	COG1289	transmembrane transporter activity
HPS44_RS27250	COG3300	MHYT domain
HPS44_RS27250	COG5001	Diguanylate cyclase
HPS44_RS27300	COG1253	flavin adenine dinucleotide binding
HPS44_RS27315	COG2205	protein histidine kinase activity
HPS44_RS27485	COG3706	GGDEF domain
HPS44_RS27490	COG0789	Transcriptional regulator
HPS44_RS27500	COG3706	GGDEF domain
HPS44_RS27530	COG1116	anion transmembrane transporter activity
HPS44_RS27535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS27540	COG4521	taurine ABC transporter
HPS44_RS27565	COG0793	Belongs to the peptidase S41A family
HPS44_RS27585	COG0628	permease
HPS44_RS27595	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPS44_RS27610	COG0531	amino acid
HPS44_RS27620	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPS44_RS27625	COG4608	Belongs to the ABC transporter superfamily
HPS44_RS27630	COG0444	Belongs to the ABC transporter superfamily
HPS44_RS27640	COG0601	transmembrane transport
HPS44_RS27645	COG0747	negative chemotaxis
HPS44_RS27655	COG0251	oxidation-reduction process
HPS44_RS27675	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPS44_RS27690	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HPS44_RS27705	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPS44_RS27715	COG3971	2-oxopent-4-enoate hydratase activity
HPS44_RS27745	COG0625	glutathione transferase activity
HPS44_RS27760	COG0477	Major facilitator Superfamily
HPS44_RS27770	COG0579	oxidoreductase
HPS44_RS27785	COG0625	glutathione transferase activity
HPS44_RS27800	COG0431	NADPH-dependent FMN reductase
HPS44_RS27810	COG0798	PFAM Bile acid sodium symporter
HPS44_RS27820	COG0640	Transcriptional regulator
HPS44_RS27825	COG0071	Belongs to the small heat shock protein (HSP20) family
HPS44_RS27860	COG1914	H( )-stimulated, divalent metal cation uptake system
HPS44_RS27865	COG0589	response to stress
HPS44_RS27880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPS44_RS27885	COG2197	response regulator
HPS44_RS27900	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HPS44_RS27905	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPS44_RS27910	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HPS44_RS27920	COG0589	response to stress
HPS44_RS27930	COG0589	response to stress
HPS44_RS27940	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HPS44_RS27960	COG1126	abc transporter atp-binding protein
HPS44_RS27965	COG0765	amino acid transport
HPS44_RS27970	COG4597	amino acid ABC transporter
HPS44_RS27975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS27980	COG0626	cystathionine gamma-synthase activity
HPS44_RS27985	COG0583	DNA-binding transcription factor activity
HPS44_RS28005	COG0444	Belongs to the ABC transporter superfamily
HPS44_RS28015	COG0601	transmembrane transport
HPS44_RS28020	COG0747	negative chemotaxis
HPS44_RS28030	COG0583	DNA-binding transcription factor activity
HPS44_RS28035	COG1335	isochorismatase
HPS44_RS28040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPS44_RS28050	COG2358	TRAP transporter, solute receptor (TAXI family
HPS44_RS28055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS28060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS28070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPS44_RS28075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPS44_RS28075	COG0519	Catalyzes the synthesis of GMP from XMP
HPS44_RS28085	COG1276	copper resistance
HPS44_RS28105	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS28110	COG3386	PFAM SMP-30 Gluconolaconase
HPS44_RS28115	COG2721	sulfolactate sulfo-lyase activity
HPS44_RS28130	COG0642	Histidine kinase
HPS44_RS28135	COG0745	RESPONSE REGULATOR receiver
HPS44_RS28145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_RS28150	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HPS44_RS28155	COG3842	ATPase activity
HPS44_RS28160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPS44_RS28180	COG0586	Pfam SNARE associated Golgi protein
HPS44_RS28185	COG0390	transport system, permease component
HPS44_RS28195	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HPS44_RS28245	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPS44_RS28250	COG1120	ATPase activity
HPS44_RS28255	COG1126	abc transporter atp-binding protein
HPS44_RS28260	COG0765	amino acid transport
HPS44_RS28270	COG2070	2-Nitropropane dioxygenase
HPS44_RS28275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPS44_RS28285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPS44_RS28310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPS44_RS28325	COG1846	Transcriptional regulator
HPS44_RS28335	COG4191	Histidine kinase
HPS44_RS28340	COG4566	intracellular signal transduction
HPS44_RS28365	COG0583	DNA-binding transcription factor activity
HPS44_RS28395	COG0765	amino acid transport
HPS44_RS28415	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HPS44_RS28440	COG0251	oxidation-reduction process
HPS44_RS28485	COG4948	Mandelate Racemase Muconate Lactonizing
HPS44_RS28495	COG1802	Transcriptional regulator
HPS44_RS28500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPS44_RS28515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS44_RS28540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS28545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPS44_RS28550	COG1116	anion transmembrane transporter activity
HPS44_RS28580	COG3154	lipid carrier protein
HPS44_RS28585	COG0826	peptidase U32
HPS44_RS28590	COG0826	peptidase U32
HPS44_RS28595	COG2197	response regulator
HPS44_RS28600	COG3850	Histidine kinase
HPS44_RS28605	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPS44_RS28610	COG0288	reversible hydration of carbon dioxide
HPS44_RS28615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPS44_RS28620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPS44_RS28625	COG2181	nitrate reductase activity
HPS44_RS28630	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPS44_RS28635	COG1140	nitrate reductase beta subunit
HPS44_RS28640	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPS44_RS28645	COG2223	nitrite transmembrane transporter activity
HPS44_RS28670	COG0583	DNA-binding transcription factor activity
HPS44_RS28690	COG0583	DNA-binding transcription factor activity
HPS44_RS28700	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS28730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS28750	COG2070	2-Nitropropane dioxygenase
HPS44_RS28765	COG5002	protein histidine kinase activity
HPS44_RS28770	COG0745	RESPONSE REGULATOR receiver
HPS44_RS28775	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HPS44_RS28780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPS44_RS28790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS44_RS28795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPS44_RS28810	COG0783	Belongs to the Dps family
HPS44_RS28840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPS44_RS28845	COG0697	spore germination
HPS44_RS28850	COG2879	small protein
HPS44_RS28855	COG1966	Carbon starvation protein
HPS44_RS28875	COG0697	spore germination
HPS44_RS28880	COG0583	DNA-binding transcription factor activity
HPS44_RS28885	COG4521	taurine ABC transporter
HPS44_RS28890	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HPS44_RS28895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPS44_RS28920	COG0235	Class ii aldolase
HPS44_RS28940	COG0523	cobalamin synthesis protein
HPS44_RS28945	COG1228	amidohydrolase
HPS44_RS28950	COG4172	Belongs to the ABC transporter superfamily
HPS44_RS28955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPS44_RS28960	COG0601	transmembrane transport
HPS44_RS28965	COG4166	transmembrane transport
HPS44_RS28980	COG1414	Transcriptional regulator
HPS44_RS28985	COG0513	Belongs to the DEAD box helicase family
HPS44_RS28990	COG0602	queuosine metabolic process
HPS44_RS28995	COG0720	synthase
HPS44_RS29005	COG1289	transmembrane transporter activity
HPS44_RS29015	COG1566	PFAM secretion protein HlyD family protein
HPS44_RS29030	COG0028	Belongs to the TPP enzyme family
HPS44_RS29040	COG1028	Short-chain dehydrogenase reductase Sdr
HPS44_RS29050	COG0400	carboxylic ester hydrolase activity
HPS44_RS29055	COG0833	amino acid
HPS44_RS29075	COG0587	DNA-directed DNA polymerase activity
HPS44_RS29095	COG0667	Aldo Keto reductase
HPS44_RS29105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPS44_RS29130	COG0765	amino acid transport
HPS44_RS29135	COG0765	amino acid transport
HPS44_RS29140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPS44_RS29145	COG0436	Aminotransferase
HPS44_RS29150	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPS44_RS29195	COG1309	transcriptional regulator
HPS44_RS29200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPS44_RS29205	COG3038	cytochrome b561
HPS44_RS29240	COG0840	transmembrane signaling receptor activity
HPS44_RS29305	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HPS44_RS29325	COG4774	siderophore transport
HPS44_RS29330	COG2345	Transcriptional regulator
HPS44_RS29340	COG1414	Transcriptional regulator
HPS44_RS29350	COG0477	Major facilitator Superfamily
HPS44_RS29355	COG0667	Aldo Keto reductase
HPS44_RS29365	COG3181	Tripartite tricarboxylate transporter family receptor
HPS44_RS29370	COG1309	transcriptional regulator
HPS44_RS29390	COG1683	Conserved Protein
HPS44_RS29400	COG2207	Transcriptional regulator
HPS44_RS29420	COG2885	chlorophyll binding
HPS44_RS29420	COG3047	cAMP biosynthetic process
HPS44_RS29425	COG3795	YCII-related domain
HPS44_RS29430	COG3795	YCII-related domain
HPS44_RS29440	COG4941	Belongs to the sigma-70 factor family
HPS44_RS29450	COG0697	spore germination
HPS44_RS29460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPS44_RS29470	COG0583	DNA-binding transcription factor activity