locus-tag	class	description
ACFER_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACFER_RS00020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACFER_RS00025	COG0592	DNA-directed DNA polymerase activity
ACFER_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACFER_RS00045	COG0187	DNA topoisomerase II activity
ACFER_RS00055	COG0730	response to heat
ACFER_RS00060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACFER_RS00070	COG0583	DNA-binding transcription factor activity
ACFER_RS00075	COG0281	malic enzyme
ACFER_RS00105	COG0517	IMP dehydrogenase activity
ACFER_RS00160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ACFER_RS00165	COG1473	amidohydrolase
ACFER_RS00170	COG1473	amidohydrolase
ACFER_RS00195	COG3279	Response regulator of the LytR AlgR family
ACFER_RS00210	COG0482	sulfurtransferase activity
ACFER_RS00220	COG0360	Binds together with S18 to 16S ribosomal RNA
ACFER_RS00230	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACFER_RS00240	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ACFER_RS00245	COG0359	binds to the 23S rRNA
ACFER_RS00250	COG0305	Participates in initiation and elongation during chromosome replication
ACFER_RS00255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACFER_RS00260	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACFER_RS00280	COG0786	glutamate:sodium symporter activity
ACFER_RS00295	COG1115	amino acid carrier protein
ACFER_RS00305	COG2116	formate transmembrane transporter activity
ACFER_RS00330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACFER_RS00350	COG1971	Probably functions as a manganese efflux pump
ACFER_RS00355	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACFER_RS00360	COG0697	spore germination
ACFER_RS00365	COG2873	o-acetylhomoserine
ACFER_RS00375	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACFER_RS00385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACFER_RS00395	COG0583	DNA-binding transcription factor activity
ACFER_RS00400	COG4948	Mandelate Racemase Muconate Lactonizing
ACFER_RS00405	COG2610	gluconate transmembrane transporter activity
ACFER_RS00410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACFER_RS00420	COG0674	pyruvate-flavodoxin oxidoreductase activity
ACFER_RS00420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ACFER_RS00425	COG1013	pyruvate-flavodoxin oxidoreductase activity
ACFER_RS00435	COG0129	dihydroxy-acid dehydratase activity
ACFER_RS00445	COG0427	acetyl-CoA hydrolase
ACFER_RS00455	COG2721	sulfolactate sulfo-lyase activity
ACFER_RS00460	COG1757	Na H antiporter
ACFER_RS00465	COG0735	belongs to the Fur family
ACFER_RS00470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACFER_RS00475	COG1121	(ABC) transporter
ACFER_RS00480	COG0803	Belongs to the bacterial solute-binding protein 9 family
ACFER_RS00490	COG0745	RESPONSE REGULATOR receiver
ACFER_RS00495	COG2205	protein histidine kinase activity
ACFER_RS00510	COG1733	regulation of RNA biosynthetic process
ACFER_RS00520	COG0583	DNA-binding transcription factor activity
ACFER_RS00525	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACFER_RS00530	COG2851	Citrate transporter
ACFER_RS00535	COG0745	RESPONSE REGULATOR receiver
ACFER_RS00540	COG0642	Histidine kinase
ACFER_RS00560	COG3885	ferrous iron binding
ACFER_RS00560	COG2078	PFAM AMMECR1 domain protein
ACFER_RS00585	COG2878	Part of a membrane complex involved in electron transport
ACFER_RS00585	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACFER_RS00590	COG4657	Part of a membrane complex involved in electron transport
ACFER_RS00595	COG4660	Part of a membrane complex involved in electron transport
ACFER_RS00600	COG4659	FMN binding
ACFER_RS00605	COG4658	electron transport chain
ACFER_RS00610	COG4656	Part of a membrane complex involved in electron transport
ACFER_RS00625	COG2204	response regulator
ACFER_RS00630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACFER_RS00635	COG0772	Belongs to the SEDS family
ACFER_RS00640	COG0768	penicillin binding
ACFER_RS00670	COG5002	protein histidine kinase activity
ACFER_RS00700	COG1966	Carbon starvation protein
ACFER_RS00705	COG0277	FAD linked oxidase domain protein
ACFER_RS00715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACFER_RS00720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACFER_RS00735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ACFER_RS00740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACFER_RS00740	COG1263	PTS System
ACFER_RS00750	COG0012	GTP binding
ACFER_RS00755	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ACFER_RS00760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACFER_RS00765	COG1713	HD superfamily hydrolase involved in NAD metabolism
ACFER_RS00770	COG1316	TRANSCRIPTIONal
ACFER_RS00775	COG0799	negative regulation of ribosome biogenesis
ACFER_RS00780	COG2996	Protein conserved in bacteria
ACFER_RS00805	COG0583	DNA-binding transcription factor activity
ACFER_RS00815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACFER_RS00820	COG0066	3-isopropylmalate dehydratase activity
ACFER_RS00825	COG0473	3-isopropylmalate dehydrogenase activity
ACFER_RS00830	COG0519	Catalyzes the synthesis of GMP from XMP
ACFER_RS00835	COG0440	acetolactate synthase activity
ACFER_RS00840	COG0028	Belongs to the TPP enzyme family
ACFER_RS00845	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACFER_RS00850	COG0745	RESPONSE REGULATOR receiver
ACFER_RS00855	COG2205	protein histidine kinase activity
ACFER_RS00860	COG0028	Belongs to the TPP enzyme family
ACFER_RS00865	COG0440	acetolactate synthase activity
ACFER_RS00890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACFER_RS00895	COG1924	4 iron, 4 sulfur cluster binding
ACFER_RS00900	COG2244	polysaccharide biosynthetic process
ACFER_RS00920	COG0583	DNA-binding transcription factor activity
ACFER_RS00925	COG0739	heme binding
ACFER_RS00930	COG1695	Transcriptional regulator
ACFER_RS00935	COG0823	Involved in the tonB-independent uptake of proteins
ACFER_RS00935	COG4946	Tricorn protease homolog
ACFER_RS00935	COG1506	peptidase
ACFER_RS00940	COG3384	dioxygenase
ACFER_RS00945	COG1012	belongs to the aldehyde dehydrogenase family
ACFER_RS00950	COG2309	aminopeptidase activity
ACFER_RS00960	COG1269	ATP hydrolysis coupled proton transport
ACFER_RS00965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACFER_RS00980	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
ACFER_RS00985	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
ACFER_RS00990	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
ACFER_RS00995	COG1394	ATPase activity, coupled to movement of substances
ACFER_RS01000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACFER_RS01015	COG0492	ferredoxin-NADP+ reductase activity
ACFER_RS01025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACFER_RS01035	COG1278	Cold shock
ACFER_RS01040	COG1028	Short-chain dehydrogenase reductase Sdr
ACFER_RS01045	COG1114	Component of the transport system for branched-chain amino acids
ACFER_RS01075	COG1027	Aspartate ammonia-lyase
ACFER_RS01080	COG1380	Effector of murein hydrolase LrgA
ACFER_RS01085	COG1346	cytolysis
ACFER_RS01090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACFER_RS01095	COG1288	antiporter activity
ACFER_RS01100	COG0385	Bile acid
ACFER_RS01110	COG2084	Dehydrogenase
ACFER_RS01120	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACFER_RS01125	COG3842	ATPase activity
ACFER_RS01130	COG0251	oxidation-reduction process
ACFER_RS01135	COG1414	Transcriptional regulator
ACFER_RS01140	COG0010	Belongs to the arginase family
ACFER_RS01145	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ACFER_RS01170	COG0786	glutamate:sodium symporter activity
ACFER_RS01175	COG1704	LemA family
ACFER_RS01200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACFER_RS01205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACFER_RS01210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACFER_RS01215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACFER_RS01220	COG1136	(ABC) transporter
ACFER_RS01225	COG1136	(ABC) transporter
ACFER_RS01225	COG0577	efflux transmembrane transporter activity
ACFER_RS01245	COG3404	Formiminotransferase-cyclodeaminase
ACFER_RS01255	COG3829	transcription factor binding
ACFER_RS01260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACFER_RS01265	COG2986	histidine ammonia-lyase
ACFER_RS01270	COG2056	Na+-H+ antiporter family
ACFER_RS01280	COG0277	FAD linked oxidase domain protein
ACFER_RS01290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACFER_RS01300	COG4178	(ABC) transporter
ACFER_RS01305	COG1115	amino acid carrier protein
ACFER_RS01315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACFER_RS01365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACFER_RS01370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACFER_RS01375	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACFER_RS01380	COG0250	Participates in transcription elongation, termination and antitermination
ACFER_RS01385	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACFER_RS01390	COG0081	regulation of translation
ACFER_RS01395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACFER_RS01400	COG0222	ribosome binding
ACFER_RS01405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACFER_RS01410	COG2011	ABC-type metal ion transport system permease component
ACFER_RS01420	COG1473	amidohydrolase
ACFER_RS01425	COG2707	UPF0756 membrane protein
ACFER_RS01440	COG1538	Outer membrane efflux protein
ACFER_RS01445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACFER_RS01450	COG1131	(ABC) transporter
ACFER_RS01455	COG0842	Transport permease protein
ACFER_RS01460	COG0842	Transport permease protein
ACFER_RS01495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACFER_RS01495	COG0512	Glutamine amidotransferase of anthranilate synthase
ACFER_RS01505	COG0134	indole-3-glycerol-phosphate synthase activity
ACFER_RS01510	COG0135	phosphoribosylanthranilate isomerase activity
ACFER_RS01520	COG0159	tryptophan synthase activity
ACFER_RS01545	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACFER_RS01545	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACFER_RS01550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACFER_RS01565	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACFER_RS01575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACFER_RS01595	COG0181	hydroxymethylbilane synthase activity
ACFER_RS01605	COG1648	precorrin-2 dehydrogenase activity
ACFER_RS01605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACFER_RS01610	COG1773	rubredoxin
ACFER_RS01610	COG1592	Rubrerythrin
ACFER_RS01620	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ACFER_RS01625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACFER_RS01630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACFER_RS01640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACFER_RS01650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACFER_RS01650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACFER_RS01655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACFER_RS01665	COG2815	serine threonine protein kinase
ACFER_RS01665	COG0515	serine threonine protein kinase
ACFER_RS01670	COG1162	GTPase activity
ACFER_RS01675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACFER_RS01690	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ACFER_RS01695	COG0811	peptide transport
ACFER_RS01700	COG0848	biopolymer transport protein
ACFER_RS01735	COG0798	PFAM Bile acid sodium symporter
ACFER_RS01750	COG1733	regulation of RNA biosynthetic process
ACFER_RS01760	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACFER_RS01765	COG0436	Aminotransferase
ACFER_RS01775	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACFER_RS01780	COG1177	transmembrane transport
ACFER_RS01795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACFER_RS01805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACFER_RS01815	COG0085	RNA polymerase activity
ACFER_RS01820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACFER_RS01830	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ACFER_RS01840	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ACFER_RS01845	COG1122	ATPase activity
ACFER_RS01850	COG1122	ATPase activity
ACFER_RS01855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ACFER_RS01860	COG0101	tRNA pseudouridine synthase activity
ACFER_RS01865	COG4206	TonB-dependent receptor
ACFER_RS01880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACFER_RS01880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACFER_RS01890	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ACFER_RS01895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACFER_RS01905	COG1418	mRNA catabolic process
ACFER_RS01920	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ACFER_RS01925	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ACFER_RS01940	COG1151	hydroxylamine reductase activity
ACFER_RS01945	COG3189	MarR family transcriptional regulator
ACFER_RS01955	COG1301	dicarboxylic acid transport
ACFER_RS01960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACFER_RS01965	COG0583	DNA-binding transcription factor activity
ACFER_RS01970	COG1268	BioY protein
ACFER_RS01975	COG0183	Belongs to the thiolase family
ACFER_RS01980	COG1021	2,3-dihydroxybenzoate-AMP ligase
ACFER_RS01995	COG1720	tRNA m6t6A37 methyltransferase activity
ACFER_RS02020	COG2731	YhcH YjgK YiaL family protein
ACFER_RS02025	COG4771	TonB-dependent receptor
ACFER_RS02085	COG1827	regulation of RNA biosynthetic process
ACFER_RS02105	COG0525	valine-tRNA ligase activity
ACFER_RS02110	COG0285	dihydrofolate synthase activity
ACFER_RS02120	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACFER_RS02125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ACFER_RS02130	COG0058	SHG alpha-glucan phosphorylase activity
ACFER_RS02135	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ACFER_RS02140	COG0297	glycogen (starch) synthase activity
ACFER_RS02145	COG3103	Sh3 type 3 domain protein
ACFER_RS02145	COG0366	Alpha amylase catalytic
ACFER_RS02150	COG2851	Citrate transporter
ACFER_RS02155	COG2851	Citrate transporter
ACFER_RS02170	COG3052	prosthetic group binding
ACFER_RS02175	COG0583	DNA-binding transcription factor activity
ACFER_RS02185	COG2855	membrane
ACFER_RS02195	COG1760	l-serine dehydratase
ACFER_RS02200	COG1760	l-serine dehydratase
ACFER_RS02205	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ACFER_RS02215	COG0254	rRNA binding
ACFER_RS02220	COG3872	metal-dependent enzyme
ACFER_RS02225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACFER_RS02230	COG2890	protein-(glutamine-N5) methyltransferase activity
ACFER_RS02235	COG0009	L-threonylcarbamoyladenylate synthase
ACFER_RS02240	COG0698	ribose 5-phosphate isomerase
ACFER_RS02245	COG4475	Protein of unknown function (DUF436)
ACFER_RS02250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACFER_RS02255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACFER_RS02260	COG2131	deaminase
ACFER_RS02295	COG0589	response to stress
ACFER_RS02300	COG0589	response to stress
ACFER_RS02305	COG0589	response to stress
ACFER_RS02310	COG0589	response to stress
ACFER_RS02315	COG0589	response to stress
ACFER_RS02320	COG1757	Na H antiporter
ACFER_RS02325	COG1115	amino acid carrier protein
ACFER_RS02330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACFER_RS02340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACFER_RS02345	COG0237	dephospho-CoA kinase activity
ACFER_RS02375	COG2610	gluconate transmembrane transporter activity
ACFER_RS02380	COG0396	ATPase activity
ACFER_RS02385	COG0719	Fe-S assembly protein
ACFER_RS02395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACFER_RS02400	COG0822	iron-sulfur transferase activity
ACFER_RS02405	COG1185	polyribonucleotide nucleotidyltransferase activity
ACFER_RS02410	COG2190	(PTS) system
ACFER_RS02420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACFER_RS02425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACFER_RS02430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACFER_RS02445	COG0351	phosphomethylpyrimidine kinase
ACFER_RS02450	COG0352	thiamine-phosphate diphosphorylase activity
ACFER_RS02460	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ACFER_RS02465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACFER_RS02490	COG0336	Belongs to the RNA methyltransferase TrmD family
ACFER_RS02495	COG0335	large ribosomal subunit rRNA binding
ACFER_RS02500	COG0681	Belongs to the peptidase S26 family
ACFER_RS02510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACFER_RS02515	COG0792	nuclease activity
ACFER_RS02520	COG0606	chelatase, subunit chli
ACFER_RS02525	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACFER_RS02540	COG0572	uridine kinase
ACFER_RS02545	COG0436	Aminotransferase
ACFER_RS02555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACFER_RS02565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACFER_RS02570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACFER_RS02575	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACFER_RS02590	COG1611	Belongs to the LOG family
ACFER_RS02605	COG0463	Glycosyl transferase, family 2
ACFER_RS02610	COG1442	glycosyl transferase family 8
ACFER_RS02650	COG1115	amino acid carrier protein
ACFER_RS02655	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACFER_RS02660	COG0740	serine-type endopeptidase activity
ACFER_RS02665	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACFER_RS02670	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACFER_RS02675	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACFER_RS02685	COG4796	Type ii and iii secretion system protein
ACFER_RS02695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACFER_RS02700	COG2860	membrane
ACFER_RS02705	COG1666	GTP binding
ACFER_RS02715	COG0556	nucleotide-excision repair
ACFER_RS02725	COG0322	excinuclease ABC activity
ACFER_RS02730	COG1773	rubredoxin
ACFER_RS02735	COG0583	DNA-binding transcription factor activity
ACFER_RS02745	COG1979	alcohol dehydrogenase
ACFER_RS02760	COG0656	L-ascorbic acid biosynthetic process
ACFER_RS02765	COG0656	L-ascorbic acid biosynthetic process
ACFER_RS02795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACFER_RS02800	COG0805	protein transport
ACFER_RS02820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACFER_RS02830	COG0583	DNA-binding transcription factor activity
ACFER_RS02845	COG0561	phosphatase activity
ACFER_RS02855	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ACFER_RS02900	COG1024	Enoyl-CoA hydratase
ACFER_RS02910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACFER_RS02915	COG1217	gtp-binding protein TYPA
ACFER_RS02935	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACFER_RS02955	COG0569	domain protein
ACFER_RS02965	COG4464	protein tyrosine phosphatase activity
ACFER_RS02980	COG0489	protein tyrosine kinase activity
ACFER_RS02985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACFER_RS02990	COG1215	transferase activity, transferring glycosyl groups
ACFER_RS03005	COG0438	transferase activity, transferring glycosyl groups
ACFER_RS03040	COG1091	dTDP-4-dehydrorhamnose reductase activity
ACFER_RS03105	COG0166	Belongs to the GPI family
ACFER_RS03110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACFER_RS03120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACFER_RS03125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACFER_RS03130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACFER_RS03140	COG0165	Argininosuccinate lyase
ACFER_RS03145	COG1473	amidohydrolase
ACFER_RS03150	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ACFER_RS03160	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ACFER_RS03165	COG1227	inorganic diphosphatase activity
ACFER_RS03210	COG3681	Belongs to the UPF0597 family
ACFER_RS03215	COG2252	PERMEase
ACFER_RS03225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACFER_RS03230	COG1966	Carbon starvation protein
ACFER_RS03240	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACFER_RS03250	COG1702	phosphate starvation-inducible protein PhoH
ACFER_RS03255	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACFER_RS03265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACFER_RS03270	COG1253	flavin adenine dinucleotide binding
ACFER_RS03275	COG1381	Involved in DNA repair and RecF pathway recombination
ACFER_RS03285	COG0708	Exodeoxyribonuclease III
ACFER_RS03295	COG0583	DNA-binding transcription factor activity
ACFER_RS03310	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACFER_RS03315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACFER_RS03325	COG0495	leucyl-tRNA aminoacylation
ACFER_RS03330	COG1982	Orn Lys Arg decarboxylase major
ACFER_RS03335	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACFER_RS03340	COG0470	DNA polymerase III
ACFER_RS03345	COG1774	PSP1 C-terminal conserved region
ACFER_RS03350	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ACFER_RS03355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACFER_RS03370	COG0534	Mate efflux family protein
ACFER_RS03380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACFER_RS03390	COG3858	chitin binding
ACFER_RS03395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACFER_RS03400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACFER_RS03405	COG0765	amino acid transport
ACFER_RS03410	COG1126	abc transporter atp-binding protein
ACFER_RS03415	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACFER_RS03420	COG0653	protein targeting
ACFER_RS03425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACFER_RS03440	COG2884	Cell division ATP-binding protein ftsE
ACFER_RS03445	COG2177	Part of the ABC transporter FtsEX involved in
ACFER_RS03455	COG0793	Belongs to the peptidase S41A family
ACFER_RS03460	COG2198	Histidine kinase
ACFER_RS03460	COG0784	Response regulator, receiver
ACFER_RS03460	COG2205	protein histidine kinase activity
ACFER_RS03465	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ACFER_RS03475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACFER_RS03480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACFER_RS03485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACFER_RS03530	COG0519	Catalyzes the synthesis of GMP from XMP
ACFER_RS03560	COG0534	Mate efflux family protein
ACFER_RS03565	COG1473	amidohydrolase
ACFER_RS03575	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACFER_RS03585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACFER_RS03605	COG1959	2 iron, 2 sulfur cluster binding
ACFER_RS03630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACFER_RS03640	COG0281	malic enzyme
ACFER_RS03670	COG0471	metal ion transport
ACFER_RS03675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACFER_RS03680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACFER_RS03685	COG1420	regulation of RNA biosynthetic process
ACFER_RS03690	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACFER_RS03695	COG0443	Heat shock 70 kDa protein
ACFER_RS03700	COG0484	heat shock protein binding
ACFER_RS03720	COG2264	protein methyltransferase activity
ACFER_RS03725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACFER_RS03730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACFER_RS03735	COG0537	adenosine 5'-monophosphoramidase activity
ACFER_RS03745	COG1610	YqeY-like protein
ACFER_RS03750	COG0436	Aminotransferase
ACFER_RS03765	COG4956	integral membrane protein (PIN domain superfamily)
ACFER_RS03770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACFER_RS03770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACFER_RS03775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACFER_RS03780	COG0215	cysteine-tRNA ligase activity
ACFER_RS03785	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ACFER_RS03850	COG0562	UDP-galactopyranose mutase
ACFER_RS03915	COG3475	LICD family
ACFER_RS03925	COG1088	dTDP-glucose 4,6-dehydratase activity
ACFER_RS03930	COG1216	Glycosyl transferase, family 2
ACFER_RS03935	COG1216	Glycosyl transferase, family 2
ACFER_RS03935	COG1442	glycosyl transferase family 8
ACFER_RS04005	COG1518	maintenance of DNA repeat elements
ACFER_RS04010	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ACFER_RS04035	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ACFER_RS04040	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ACFER_RS04045	COG0688	phosphatidylethanolamine metabolic process
ACFER_RS04055	COG1215	transferase activity, transferring glycosyl groups
ACFER_RS04075	COG0385	Bile acid
ACFER_RS04080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACFER_RS04085	COG1126	abc transporter atp-binding protein
ACFER_RS04090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACFER_RS04095	COG0765	amino acid transport
ACFER_RS04100	COG0765	amino acid transport
ACFER_RS04120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACFER_RS04130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACFER_RS04140	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACFER_RS04150	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ACFER_RS04160	COG1464	Belongs to the NlpA lipoprotein family
ACFER_RS04165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACFER_RS04170	COG0564	pseudouridine synthase activity
ACFER_RS04235	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ACFER_RS04240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACFER_RS04255	COG0640	Transcriptional regulator
ACFER_RS04260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACFER_RS04270	COG0515	serine threonine protein kinase
ACFER_RS04275	COG2384	SAM-dependent methyltransferase
ACFER_RS04280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACFER_RS04285	COG3481	metal-dependent phosphohydrolase, HD sub domain
ACFER_RS04295	COG0463	Glycosyl transferase, family 2
ACFER_RS04300	COG3103	Sh3 type 3 domain protein
ACFER_RS04300	COG1388	LysM domain
ACFER_RS04300	COG0791	NLP P60 protein
ACFER_RS04310	COG0745	RESPONSE REGULATOR receiver
ACFER_RS04315	COG5002	protein histidine kinase activity
ACFER_RS04325	COG3679	Belongs to the UPF0342 family
ACFER_RS04335	COG0697	spore germination
ACFER_RS04345	COG1970	mechanosensitive ion channel activity
ACFER_RS04350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACFER_RS04355	COG0318	PFAM AMP-dependent synthetase and ligase
ACFER_RS04365	COG3850	Histidine kinase
ACFER_RS04370	COG2197	response regulator
ACFER_RS04380	COG0737	Belongs to the 5'-nucleotidase family
ACFER_RS04425	COG1302	Protein conserved in bacteria
ACFER_RS04440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACFER_RS04450	COG1570	exodeoxyribonuclease VII activity
ACFER_RS04455	COG1722	exodeoxyribonuclease VII activity
ACFER_RS04465	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACFER_RS04470	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ACFER_RS04475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACFER_RS04485	COG0497	DNA recombination
ACFER_RS04490	COG0494	nUDIX hydrolase
ACFER_RS04495	COG2359	stage V sporulation protein S
ACFER_RS04505	COG1116	anion transmembrane transporter activity
ACFER_RS04535	COG0371	Dehydrogenase
ACFER_RS04540	COG0534	Mate efflux family protein
ACFER_RS04550	COG2200	EAL domain
ACFER_RS04550	COG2202	Pas domain
ACFER_RS04550	COG2199	diguanylate cyclase activity
ACFER_RS04585	COG2217	Heavy metal translocating P-type atpase
ACFER_RS04615	COG1132	(ABC) transporter
ACFER_RS04620	COG1132	(ABC) transporter
ACFER_RS04630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACFER_RS04635	COG0072	phenylalanine-tRNA ligase activity
ACFER_RS04635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACFER_RS04690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACFER_RS04705	COG4472	Bacterial protein of unknown function (DUF965)
ACFER_RS04710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACFER_RS04715	COG3906	Belongs to the UPF0473 family
ACFER_RS04720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACFER_RS04725	COG0826	peptidase U32
ACFER_RS04730	COG0006	proline dipeptidase activity
ACFER_RS04735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACFER_RS04740	COG0406	alpha-ribazole phosphatase activity
ACFER_RS04755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACFER_RS04765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACFER_RS04780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACFER_RS04785	COG0583	DNA-binding transcription factor activity
ACFER_RS04795	COG4496	protein, YerC YecD
ACFER_RS04800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACFER_RS04815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACFER_RS04820	COG0131	Imidazoleglycerol-phosphate dehydratase
ACFER_RS04825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACFER_RS04830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACFER_RS04835	COG0107	imidazoleglycerol-phosphate synthase activity
ACFER_RS04840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACFER_RS04840	COG0140	phosphoribosyl-ATP diphosphatase activity
ACFER_RS04845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACFER_RS04850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACFER_RS04855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACFER_RS04860	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ACFER_RS04890	COG0148	phosphopyruvate hydratase activity
ACFER_RS04895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ACFER_RS04900	COG2357	RelA SpoT domain protein
ACFER_RS04905	COG0745	RESPONSE REGULATOR receiver
ACFER_RS04910	COG5002	protein histidine kinase activity
ACFER_RS04915	COG0673	inositol 2-dehydrogenase activity
ACFER_RS04945	COG2814	Major facilitator Superfamily
ACFER_RS04970	COG0583	DNA-binding transcription factor activity
ACFER_RS05005	COG0242	peptide deformylase activity
ACFER_RS05010	COG1309	transcriptional regulator
ACFER_RS05015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACFER_RS05020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACFER_RS05035	COG0583	DNA-binding transcription factor activity
ACFER_RS05060	COG0557	exoribonuclease II activity
ACFER_RS05070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACFER_RS05090	COG1799	cell septum assembly
ACFER_RS05095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACFER_RS05115	COG2086	electron transfer activity
ACFER_RS05120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ACFER_RS05160	COG1592	Rubrerythrin
ACFER_RS05160	COG1773	rubredoxin
ACFER_RS05175	COG1309	transcriptional regulator
ACFER_RS05180	COG0191	fructose-bisphosphate aldolase activity
ACFER_RS05185	COG0564	pseudouridine synthase activity
ACFER_RS05190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACFER_RS05195	COG1606	tRNA processing
ACFER_RS05200	COG1691	(AIR) carboxylase
ACFER_RS05205	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ACFER_RS05210	COG0310	cobalt ion transport
ACFER_RS05220	COG1122	ATPase activity
ACFER_RS05230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACFER_RS05235	COG0785	Cytochrome C biogenesis protein
ACFER_RS05240	COG1301	dicarboxylic acid transport
ACFER_RS05245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACFER_RS05250	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ACFER_RS05255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACFER_RS05260	COG0513	Belongs to the DEAD box helicase family
ACFER_RS05265	COG1546	Belongs to the CinA family
ACFER_RS05265	COG1058	Belongs to the CinA family
ACFER_RS05270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACFER_RS05275	COG1426	Protein conserved in bacteria
ACFER_RS05280	COG1674	ftsk spoiiie
ACFER_RS05285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ACFER_RS05290	COG2358	TRAP transporter, solute receptor (TAXI family
ACFER_RS05305	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACFER_RS05315	COG0613	PHP domain protein
ACFER_RS05325	COG2814	Major facilitator Superfamily
ACFER_RS05345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACFER_RS05345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACFER_RS05345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACFER_RS05350	COG1105	Belongs to the carbohydrate kinase PfkB family
ACFER_RS05355	COG3394	polysaccharide catabolic process
ACFER_RS05360	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ACFER_RS05365	COG0039	L-malate dehydrogenase activity
ACFER_RS05370	COG1362	aminopeptidase activity
ACFER_RS05375	COG0531	amino acid
ACFER_RS05380	COG3579	cysteine-type endopeptidase activity
ACFER_RS05400	COG1132	(ABC) transporter
ACFER_RS05410	COG0583	DNA-binding transcription factor activity
ACFER_RS05415	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACFER_RS05450	COG2020	methyltransferase activity
ACFER_RS05495	COG2081	HI0933 family
ACFER_RS05510	COG2851	Citrate transporter
ACFER_RS05525	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
ACFER_RS05555	COG1475	DNA binding
ACFER_RS05670	COG2186	Transcriptional regulator
ACFER_RS05700	COG0494	nUDIX hydrolase
ACFER_RS05780	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACFER_RS05890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ACFER_RS05935	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
ACFER_RS05970	COG0640	Transcriptional regulator
ACFER_RS05990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACFER_RS06010	COG1522	sequence-specific DNA binding
ACFER_RS06015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACFER_RS06020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACFER_RS06025	COG2011	ABC-type metal ion transport system permease component
ACFER_RS06065	COG0489	protein tyrosine kinase activity
ACFER_RS06070	COG4964	Belongs to the GSP D family
ACFER_RS06090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACFER_RS06095	COG0527	aspartate kinase activity
ACFER_RS06100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACFER_RS06115	COG0756	dUTP diphosphatase activity
ACFER_RS06125	COG0352	thiamine-phosphate diphosphorylase activity
ACFER_RS06130	COG2033	superoxide reductase activity
ACFER_RS06145	COG1328	CTP reductase activity
ACFER_RS06145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACFER_RS06155	COG0786	glutamate:sodium symporter activity
ACFER_RS06165	COG4974	Belongs to the 'phage' integrase family
ACFER_RS06170	COG1923	regulation of RNA biosynthetic process
ACFER_RS06175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACFER_RS06185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACFER_RS06190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACFER_RS06195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACFER_RS06215	COG1484	DNA-dependent DNA replication
ACFER_RS06245	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACFER_RS06245	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACFER_RS06250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACFER_RS06255	COG1469	GTP cyclohydrolase I activity
ACFER_RS06260	COG0720	synthase
ACFER_RS06265	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACFER_RS06275	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACFER_RS06280	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ACFER_RS06285	COG0083	homoserine kinase activity
ACFER_RS06290	COG0460	homoserine dehydrogenase
ACFER_RS06295	COG4492	Belongs to the UPF0735 family
ACFER_RS06300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACFER_RS06305	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACFER_RS06315	COG1304	FMN binding
ACFER_RS06320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACFER_RS06320	COG0539	negative regulation of cytoplasmic translation
ACFER_RS06330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACFER_RS06335	COG2081	HI0933 family
ACFER_RS06340	COG1187	pseudouridine synthase activity
ACFER_RS06345	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACFER_RS06355	COG1994	Peptidase M50
ACFER_RS06365	COG4974	Belongs to the 'phage' integrase family
ACFER_RS06370	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ACFER_RS06375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACFER_RS06380	COG0758	DNA mediated transformation
ACFER_RS06385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACFER_RS06400	COG1047	Peptidyl-prolyl cis-trans
ACFER_RS06425	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACFER_RS06460	COG0534	Mate efflux family protein
ACFER_RS06470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ACFER_RS06475	COG0385	Bile acid
ACFER_RS06480	COG2239	Acts as a magnesium transporter
ACFER_RS06490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACFER_RS06500	COG0516	GMP reductase activity
ACFER_RS06500	COG0517	IMP dehydrogenase activity
ACFER_RS06505	COG0151	Belongs to the GarS family
ACFER_RS06510	COG0138	bifunctional purine biosynthesis protein purh
ACFER_RS06515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACFER_RS06520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACFER_RS06525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACFER_RS06530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACFER_RS06540	COG1193	negative regulation of DNA recombination
ACFER_RS06545	COG0826	peptidase U32
ACFER_RS06605	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACFER_RS06610	COG3856	small basic protein
ACFER_RS06625	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACFER_RS06630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACFER_RS06635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACFER_RS06645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACFER_RS06650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACFER_RS06665	COG0275	rRNA processing
ACFER_RS06670	COG2001	Belongs to the MraZ family
ACFER_RS06680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACFER_RS06685	COG0284	orotidine-5'-phosphate decarboxylase activity
ACFER_RS06690	COG0167	dihydroorotate dehydrogenase activity
ACFER_RS06695	COG0543	2 iron, 2 sulfur cluster binding
ACFER_RS06700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACFER_RS06705	COG0505	Belongs to the CarA family
ACFER_RS06710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACFER_RS06715	COG0540	Belongs to the ATCase OTCase family
ACFER_RS06725	COG1061	Type III restriction enzyme res subunit
ACFER_RS06750	COG3047	cAMP biosynthetic process
ACFER_RS06750	COG2885	chlorophyll binding
ACFER_RS06760	COG0493	'glutamate synthase
ACFER_RS06770	COG0402	S-adenosylhomocysteine deaminase activity
ACFER_RS06775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ACFER_RS06785	COG1074	ATP-dependent DNA helicase activity
ACFER_RS06790	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ACFER_RS06805	COG0037	tRNA processing
ACFER_RS06810	COG1234	tRNA 3'-trailer cleavage
ACFER_RS06825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACFER_RS06850	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ACFER_RS06855	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ACFER_RS06860	COG0471	metal ion transport
ACFER_RS06865	COG1802	Transcriptional regulator
ACFER_RS06870	COG0481	GTPase activity
ACFER_RS06875	COG0268	Binds directly to 16S ribosomal RNA
ACFER_RS06880	COG0196	riboflavin kinase activity
ACFER_RS06885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACFER_RS06890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ACFER_RS06895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACFER_RS06900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACFER_RS06900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACFER_RS06910	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ACFER_RS06915	COG0195	Participates in both transcription termination and antitermination
ACFER_RS06920	COG0779	Required for maturation of 30S ribosomal subunits
ACFER_RS06925	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACFER_RS06935	COG1473	amidohydrolase
ACFER_RS06945	COG2040	homocysteine
ACFER_RS06960	COG1115	amino acid carrier protein
ACFER_RS06965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACFER_RS06975	COG1285	pathogenesis
ACFER_RS06980	COG0442	prolyl-tRNA aminoacylation
ACFER_RS06985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACFER_RS06990	COG0750	zinc metalloprotease
ACFER_RS06995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACFER_RS07000	COG0575	Belongs to the CDS family
ACFER_RS07005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACFER_RS07015	COG0233	cytoplasmic translational termination
ACFER_RS07020	COG0528	UMP kinase activity
ACFER_RS07025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACFER_RS07030	COG0052	Belongs to the universal ribosomal protein uS2 family
ACFER_RS07035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACFER_RS07045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACFER_RS07055	COG2199	diguanylate cyclase activity
ACFER_RS07055	COG2203	Gaf domain
ACFER_RS07060	COG0571	ribonuclease III activity
ACFER_RS07065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACFER_RS07075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACFER_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
ACFER_RS07085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACFER_RS07090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACFER_RS07095	COG0416	fatty acid biosynthetic process
ACFER_RS07100	COG2030	dehydratase
ACFER_RS07105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACFER_RS07110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACFER_RS07120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACFER_RS07125	COG1323	Belongs to the UPF0348 family
ACFER_RS07135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACFER_RS07140	COG0742	ribosomal rna small subunit methyltransferase
ACFER_RS07180	COG1473	amidohydrolase
ACFER_RS07200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACFER_RS07220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACFER_RS07225	COG1758	RNA polymerase activity
ACFER_RS07230	COG0194	GDP metabolic process
ACFER_RS07235	COG2052	Domain of unknown function (DUF370)
ACFER_RS07240	COG1561	YicC-like family, N-terminal region
ACFER_RS07255	COG0129	dihydroxy-acid dehydratase activity
ACFER_RS07265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACFER_RS07275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ACFER_RS07280	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ACFER_RS07285	COG0459	protein refolding
ACFER_RS07290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACFER_RS07300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACFER_RS07310	COG1388	LysM domain
ACFER_RS07310	COG3584	3D domain protein
ACFER_RS07315	COG0084	hydrolase, TatD family'
ACFER_RS07320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACFER_RS07320	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACFER_RS07335	COG3706	GGDEF domain
ACFER_RS07345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACFER_RS07355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACFER_RS07360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACFER_RS07365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACFER_RS07370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACFER_RS07375	COG1802	Transcriptional regulator
ACFER_RS07380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACFER_RS07385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ACFER_RS07390	COG0786	glutamate:sodium symporter activity
ACFER_RS07405	COG1596	polysaccharide export
ACFER_RS07405	COG1555	photosystem II stabilization
ACFER_RS07420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACFER_RS07425	COG3437	response regulator, receiver
ACFER_RS07425	COG0784	Response regulator, receiver
ACFER_RS07435	COG1811	Na channel or pump
ACFER_RS07440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACFER_RS07455	COG1132	(ABC) transporter
ACFER_RS07470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACFER_RS07490	COG0280	phosphate acetyltransferase
ACFER_RS07500	COG1362	aminopeptidase activity
ACFER_RS07510	COG1024	Enoyl-CoA hydratase
ACFER_RS07515	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACFER_RS07525	COG0183	Belongs to the thiolase family
ACFER_RS07540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACFER_RS07545	COG2848	UPF0210 protein
ACFER_RS07555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACFER_RS07560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACFER_RS07575	COG0492	ferredoxin-NADP+ reductase activity
ACFER_RS07600	COG1937	Protein conserved in bacteria
ACFER_RS07605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACFER_RS07610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACFER_RS07615	COG0569	domain protein
ACFER_RS07620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACFER_RS07625	COG1304	FMN binding
ACFER_RS07650	COG0552	protein localization to endoplasmic reticulum
ACFER_RS07655	COG1196	nuclear chromosome segregation
ACFER_RS07660	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ACFER_RS07665	COG0564	pseudouridine synthase activity
ACFER_RS07670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACFER_RS07690	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACFER_RS07695	COG0124	histidyl-tRNA synthetase
ACFER_RS07700	COG0628	permease
ACFER_RS07705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACFER_RS07710	COG1490	D-aminoacyl-tRNA deacylase activity
ACFER_RS07715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACFER_RS07720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACFER_RS07720	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ACFER_RS07735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACFER_RS07740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACFER_RS07750	COG1862	Preprotein translocase
ACFER_RS07760	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACFER_RS07765	COG2385	sporulation resulting in formation of a cellular spore
ACFER_RS07765	COG2247	cell wall binding repeat
ACFER_RS07770	COG2255	four-way junction helicase activity
ACFER_RS07775	COG0632	four-way junction helicase activity
ACFER_RS07780	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACFER_RS07785	COG0217	transcriptional regulatory protein
ACFER_RS07800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACFER_RS07800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACFER_RS07815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACFER_RS07820	COG1592	Rubrerythrin
ACFER_RS07840	COG1464	Belongs to the NlpA lipoprotein family
ACFER_RS07845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACFER_RS07880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACFER_RS07885	COG0798	PFAM Bile acid sodium symporter
ACFER_RS07935	COG1451	nucleotide metabolic process
ACFER_RS07940	COG4536	flavin adenine dinucleotide binding
ACFER_RS07955	COG0024	Methionine aminopeptidase
ACFER_RS08000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACFER_RS08020	COG0583	DNA-binding transcription factor activity
ACFER_RS08025	COG1960	acyl-CoA dehydrogenase activity
ACFER_RS08030	COG0426	domain, Protein
ACFER_RS08050	COG1214	PFAM Peptidase M22, glycoprotease
ACFER_RS08055	COG0802	atpase or kinase
ACFER_RS08060	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ACFER_RS08065	COG1960	acyl-CoA dehydrogenase activity
ACFER_RS08075	COG1388	LysM domain
ACFER_RS08075	COG3584	3D domain protein
ACFER_RS08080	COG0174	glutamine synthetase
ACFER_RS08095	COG4948	Mandelate Racemase Muconate Lactonizing
ACFER_RS08100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACFER_RS08110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACFER_RS08115	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACFER_RS08120	COG1268	BioY protein
ACFER_RS08130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACFER_RS08135	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ACFER_RS08140	COG0037	tRNA processing
ACFER_RS08145	COG1098	S1 RNA binding domain
ACFER_RS08150	COG2217	Heavy metal translocating P-type atpase
ACFER_RS08170	COG2379	hydroxypyruvate reductase
ACFER_RS08175	COG0668	transmembrane transport
ACFER_RS08180	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACFER_RS08185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACFER_RS08190	COG0077	Prephenate dehydratase
ACFER_RS08190	COG1605	Chorismate mutase
ACFER_RS08195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACFER_RS08200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACFER_RS08205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACFER_RS08210	COG0287	Prephenate dehydrogenase
ACFER_RS08215	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ACFER_RS08225	COG0489	protein tyrosine kinase activity
ACFER_RS08235	COG0776	regulation of translation
ACFER_RS08240	COG3956	TIGRFAM MazG family protein
ACFER_RS08245	COG2244	polysaccharide biosynthetic process
ACFER_RS08250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACFER_RS08255	COG1494	fructose-1,6-bisphosphatase
ACFER_RS08260	COG0504	CTP synthase activity
ACFER_RS08265	COG0018	arginyl-trna synthetase
ACFER_RS08275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACFER_RS08285	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACFER_RS08290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACFER_RS08290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACFER_RS08295	COG0736	holo-[acyl-carrier-protein] synthase activity
ACFER_RS08300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACFER_RS08320	COG4120	Belongs to the binding-protein-dependent transport system permease family
ACFER_RS08340	COG0501	Belongs to the peptidase M48B family
ACFER_RS08345	COG0420	3'-5' exonuclease activity
ACFER_RS08350	COG0419	ATPase involved in DNA repair
ACFER_RS08355	COG0602	queuosine metabolic process
ACFER_RS08365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACFER_RS08380	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ACFER_RS08425	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACFER_RS08430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACFER_RS08435	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACFER_RS08435	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACFER_RS08440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACFER_RS08455	COG2990	Protein conserved in bacteria
ACFER_RS08485	COG1739	Uncharacterized protein family UPF0029
ACFER_RS08505	COG0497	DNA recombination
ACFER_RS08510	COG0497	DNA recombination
ACFER_RS08515	COG0497	DNA recombination
ACFER_RS08520	COG0497	DNA recombination
ACFER_RS08530	COG4372	Transposase
ACFER_RS08550	COG1137	ATPase activity
ACFER_RS08570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACFER_RS08580	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACFER_RS08590	COG1663	tetraacyldisaccharide 4'-kinase activity
ACFER_RS08595	COG1132	(ABC) transporter
ACFER_RS08600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACFER_RS08605	COG3494	Protein of unknown function (DUF1009)
ACFER_RS08610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACFER_RS08630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACFER_RS08650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACFER_RS08670	COG1127	ABC transporter
ACFER_RS08675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACFER_RS08680	COG0750	zinc metalloprotease
ACFER_RS08690	COG5434	Belongs to the glycosyl hydrolase 28 family
ACFER_RS08690	COG4632	Exopolysaccharide biosynthesis protein
ACFER_RS08695	COG1077	Cell shape determining protein MreB Mrl
ACFER_RS08700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACFER_RS08725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACFER_RS08730	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACFER_RS08735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACFER_RS08740	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACFER_RS08745	COG0356	it plays a direct role in the translocation of protons across the membrane
ACFER_RS08755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACFER_RS08760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACFER_RS08775	COG0534	Mate efflux family protein
ACFER_RS08780	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACFER_RS08800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACFER_RS08805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACFER_RS08810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACFER_RS08820	COG0277	FAD linked oxidase domain protein
ACFER_RS08830	COG0590	tRNA wobble adenosine to inosine editing
ACFER_RS08835	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ACFER_RS08855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACFER_RS08880	COG0300	oxidoreductase activity
ACFER_RS08885	COG1247	-acetyltransferase
ACFER_RS08905	COG1301	dicarboxylic acid transport
ACFER_RS08910	COG2721	sulfolactate sulfo-lyase activity
ACFER_RS08915	COG2721	sulfolactate sulfo-lyase activity
ACFER_RS08920	COG0583	DNA-binding transcription factor activity
ACFER_RS08925	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACFER_RS08930	COG1288	antiporter activity
ACFER_RS08945	COG1827	regulation of RNA biosynthetic process
ACFER_RS08970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACFER_RS08980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACFER_RS08985	COG0154	amidase activity
ACFER_RS08995	COG0626	cystathionine gamma-synthase activity
ACFER_RS09000	COG0473	3-isopropylmalate dehydrogenase activity
ACFER_RS09055	COG3210	domain, Protein
ACFER_RS09075	COG3210	domain, Protein
ACFER_RS09080	COG3210	domain, Protein
ACFER_RS09090	COG0751	glycine-tRNA ligase activity
ACFER_RS09095	COG0752	glycyl-tRNA synthetase alpha subunit
ACFER_RS09105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACFER_RS09110	COG0305	Participates in initiation and elongation during chromosome replication
ACFER_RS09110	COG0358	DNA primase activity
ACFER_RS09115	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ACFER_RS09120	COG0517	IMP dehydrogenase activity
ACFER_RS09125	COG0574	Belongs to the PEP-utilizing enzyme family
ACFER_RS09125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACFER_RS09135	COG4139	cobalamin transport
ACFER_RS09165	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACFER_RS09170	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACFER_RS09175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACFER_RS09180	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACFER_RS09195	COG1045	serine acetyltransferase
ACFER_RS09210	COG0561	phosphatase activity
ACFER_RS09220	COG0733	neurotransmitter:sodium symporter activity
ACFER_RS09225	COG0733	neurotransmitter:sodium symporter activity
ACFER_RS09235	COG1607	acyl-coa hydrolase
ACFER_RS09245	COG1473	amidohydrolase
ACFER_RS09255	COG1328	CTP reductase activity
ACFER_RS09265	COG1288	antiporter activity
ACFER_RS09270	COG0583	DNA-binding transcription factor activity
ACFER_RS09275	COG0427	acetyl-CoA hydrolase
ACFER_RS09285	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
ACFER_RS09290	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
ACFER_RS09295	COG1924	4 iron, 4 sulfur cluster binding
ACFER_RS09300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACFER_RS09305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACFER_RS09310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACFER_RS09315	COG0617	tRNA 3'-terminal CCA addition
ACFER_RS09320	COG1530	ribonuclease E activity
ACFER_RS09335	COG0772	Belongs to the SEDS family
ACFER_RS09355	COG1077	Cell shape determining protein MreB Mrl
ACFER_RS09360	COG2003	Belongs to the UPF0758 family
ACFER_RS09365	COG0424	maF-like protein
ACFER_RS09385	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ACFER_RS09390	COG4770	biotin carboxylase activity
ACFER_RS09400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACFER_RS09405	COG0427	acetyl-CoA hydrolase
ACFER_RS09415	COG2172	sigma factor antagonist activity
ACFER_RS09435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ACFER_RS09440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACFER_RS09450	COG0531	amino acid
ACFER_RS09455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACFER_RS09460	COG0646	methionine synthase
ACFER_RS09460	COG1410	methionine synthase
ACFER_RS09470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ACFER_RS09475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACFER_RS09480	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACFER_RS09485	COG1687	branched-chain amino acid
ACFER_RS09490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACFER_RS09500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ACFER_RS09520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACFER_RS09525	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
ACFER_RS09555	COG1194	a g-specific adenine glycosylase
ACFER_RS09560	COG2816	NAD+ diphosphatase activity
ACFER_RS09565	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACFER_RS09570	COG1984	allophanate hydrolase subunit 2
ACFER_RS09575	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ACFER_RS09580	COG1914	H( )-stimulated, divalent metal cation uptake system
ACFER_RS09585	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACFER_RS09590	COG1914	H( )-stimulated, divalent metal cation uptake system
ACFER_RS09600	COG1827	regulation of RNA biosynthetic process
ACFER_RS09605	COG0583	DNA-binding transcription factor activity
ACFER_RS09630	COG1136	(ABC) transporter
ACFER_RS09645	COG0704	Plays a role in the regulation of phosphate uptake
ACFER_RS09650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACFER_RS09655	COG0581	inorganic phosphate transmembrane transporter activity
ACFER_RS09665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACFER_RS09680	COG0010	Belongs to the arginase family
ACFER_RS09685	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACFER_RS09690	COG1982	Orn Lys Arg decarboxylase major
ACFER_RS09710	COG0488	(ABC) transporter
ACFER_RS09730	COG0622	Phosphoesterase
ACFER_RS09750	COG0202	RNA polymerase activity
ACFER_RS09755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACFER_RS09765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACFER_RS09775	COG0563	adenylate kinase activity
ACFER_RS09780	COG0201	protein transport
ACFER_RS09785	COG0200	Binds to the 23S rRNA
ACFER_RS09790	COG1841	ribosomal large subunit assembly
ACFER_RS09795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACFER_RS09800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACFER_RS09805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACFER_RS09810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACFER_RS09815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACFER_RS09825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACFER_RS09830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACFER_RS09835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACFER_RS09840	COG0255	Belongs to the universal ribosomal protein uL29 family
ACFER_RS09845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACFER_RS09850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACFER_RS09855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACFER_RS09860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACFER_RS09865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACFER_RS09870	COG0089	rRNA binding
ACFER_RS09875	COG0088	Forms part of the polypeptide exit tunnel
ACFER_RS09880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACFER_RS09890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACFER_RS09900	COG0049	tRNA binding
ACFER_RS09905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACFER_RS09910	COG1358	cellular component organization or biogenesis
ACFER_RS09935	COG0488	(ABC) transporter
ACFER_RS09940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACFER_RS09965	COG0582	viral genome integration into host DNA
ACFER_RS10000	COG1959	2 iron, 2 sulfur cluster binding
ACFER_RS10005	COG0493	'glutamate synthase
ACFER_RS10015	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ACFER_RS10020	COG2843	Capsule synthesis protein
ACFER_RS10025	COG0477	Major facilitator Superfamily
ACFER_RS10025	COG0477	Major facilitator Superfamily
ACFER_RS10040	COG0542	response to heat
ACFER_RS10050	COG0735	belongs to the Fur family
ACFER_RS10065	COG0583	DNA-binding transcription factor activity
ACFER_RS10070	COG0583	DNA-binding transcription factor activity
ACFER_RS10075	COG0473	3-isopropylmalate dehydrogenase activity
ACFER_RS10085	COG2706	6-phosphogluconolactonase activity
ACFER_RS10090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACFER_RS10095	COG0583	DNA-binding transcription factor activity
ACFER_RS10100	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACFER_RS10105	COG2828	Protein conserved in bacteria
ACFER_RS10120	COG0129	dihydroxy-acid dehydratase activity
ACFER_RS10130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACFER_RS10135	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACFER_RS10135	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACFER_RS10140	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACFER_RS10145	COG0583	DNA-binding transcription factor activity
ACFER_RS10155	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACFER_RS10160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACFER_RS10160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACFER_RS10165	COG0471	metal ion transport
ACFER_RS10170	COG1917	Cupin 2, conserved barrel domain protein
ACFER_RS10170	COG2207	Transcriptional regulator
ACFER_RS10180	COG0251	oxidation-reduction process
ACFER_RS10185	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ACFER_RS10190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACFER_RS10205	COG3829	transcription factor binding
ACFER_RS10210	COG1301	dicarboxylic acid transport
ACFER_RS10215	COG2267	carboxylic ester hydrolase activity
ACFER_RS10230	COG3842	ATPase activity
ACFER_RS10235	COG1178	ABC-type Fe3 transport system permease component
ACFER_RS10240	COG3842	ATPase activity
ACFER_RS10255	COG0010	Belongs to the arginase family
ACFER_RS10265	COG1414	Transcriptional regulator
ACFER_RS10275	COG1473	amidohydrolase
ACFER_RS10290	COG0583	DNA-binding transcription factor activity
ACFER_RS10300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACFER_RS10310	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACFER_RS10315	COG4948	Mandelate Racemase Muconate Lactonizing
ACFER_RS10355	COG0583	DNA-binding transcription factor activity
ACFER_RS10380	COG0471	metal ion transport
ACFER_RS10380	COG0490	domain, Protein
ACFER_RS10385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACFER_RS10395	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACFER_RS10400	COG0583	DNA-binding transcription factor activity
ACFER_RS10410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACFER_RS10455	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACFER_RS10460	COG2183	response to ionizing radiation
ACFER_RS10470	COG1122	ATPase activity
ACFER_RS10475	COG1122	ATPase activity
ACFER_RS10490	COG0071	Belongs to the small heat shock protein (HSP20) family
ACFER_RS10505	COG0114	fumarate hydratase activity
ACFER_RS10510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACFER_RS10530	COG0493	'glutamate synthase
ACFER_RS10535	COG3314	Sporulation integral membrane protein YlbJ
ACFER_RS10550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACFER_RS10560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ACFER_RS10580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACFER_RS10605	COG1475	DNA binding
ACFER_RS10610	COG1192	Involved in chromosome partitioning
ACFER_RS10615	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACFER_RS10625	COG0357	Ribosomal RNA small subunit methyltransferase G
ACFER_RS10630	COG0445	tRNA wobble uridine modification
ACFER_RS10635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACFER_RS10640	COG1847	R3H domain protein
ACFER_RS10650	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACFER_RS10655	COG0594	ribonuclease P activity
ACFER_RS10665	COG1473	amidohydrolase
ACFER_RS10675	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACFER_RS10680	COG0252	asparaginase activity
ACFER_RS10710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ACFER_RS10750	COG1316	TRANSCRIPTIONal
ACFER_RS10775	COG1215	transferase activity, transferring glycosyl groups
ACFER_RS10800	COG5001	Diguanylate cyclase
ACFER_RS10800	COG4251	negative regulation of phosphorylation
ACFER_RS10800	COG3706	GGDEF domain
ACFER_RS10800	COG2203	Gaf domain
ACFER_RS10820	COG0126	phosphoglycerate kinase activity
ACFER_RS10825	COG2176	DNA-directed DNA polymerase activity
ACFER_RS10860	COG0732	type I restriction modification DNA specificity domain
ACFER_RS10870	COG1360	Flagellar Motor Protein
ACFER_RS10875	COG3706	GGDEF domain
ACFER_RS10875	COG4251	negative regulation of phosphorylation
ACFER_RS10875	COG5001	Diguanylate cyclase
ACFER_RS10875	COG2203	Gaf domain
ACFER_RS10890	COG3279	Response regulator of the LytR AlgR family
ACFER_RS10895	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACFER_RS10900	COG1408	metallophosphoesterase
ACFER_RS10920	COG3300	MHYT domain
ACFER_RS10920	COG5001	Diguanylate cyclase