locus-tag	class	description
LK430_RS00010	COG0653	protein targeting
LK430_RS00015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LK430_RS00020	COG1126	abc transporter atp-binding protein
LK430_RS00025	COG0765	amino acid transport
LK430_RS00030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK430_RS00035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK430_RS00040	COG3858	chitin binding
LK430_RS00050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LK430_RS00060	COG0534	Mate efflux family protein
LK430_RS00075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LK430_RS00080	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LK430_RS00085	COG1774	PSP1 C-terminal conserved region
LK430_RS00090	COG0470	DNA polymerase III
LK430_RS00095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LK430_RS00100	COG1982	Orn Lys Arg decarboxylase major
LK430_RS00105	COG0495	leucyl-tRNA aminoacylation
LK430_RS00115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LK430_RS00120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LK430_RS00135	COG0583	DNA-binding transcription factor activity
LK430_RS00145	COG0708	Exodeoxyribonuclease III
LK430_RS00155	COG1381	Involved in DNA repair and RecF pathway recombination
LK430_RS00160	COG1253	flavin adenine dinucleotide binding
LK430_RS00165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LK430_RS00175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LK430_RS00180	COG1702	phosphate starvation-inducible protein PhoH
LK430_RS00190	COG0179	Fumarylacetoacetate (FAA) hydrolase
LK430_RS00200	COG1966	Carbon starvation protein
LK430_RS00205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LK430_RS00215	COG2252	PERMEase
LK430_RS00220	COG3681	Belongs to the UPF0597 family
LK430_RS00275	COG1227	inorganic diphosphatase activity
LK430_RS00280	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LK430_RS00290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LK430_RS00295	COG1473	amidohydrolase
LK430_RS00300	COG0165	Argininosuccinate lyase
LK430_RS00310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LK430_RS00315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LK430_RS00320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LK430_RS00325	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LK430_RS00330	COG0166	Belongs to the GPI family
LK430_RS00405	COG1091	dTDP-4-dehydrorhamnose reductase activity
LK430_RS00435	COG1215	transferase activity, transferring glycosyl groups
LK430_RS00450	COG0438	transferase activity, transferring glycosyl groups
LK430_RS00465	COG1215	transferase activity, transferring glycosyl groups
LK430_RS00470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LK430_RS00475	COG0489	protein tyrosine kinase activity
LK430_RS00490	COG4464	protein tyrosine phosphatase activity
LK430_RS00500	COG0569	domain protein
LK430_RS00520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LK430_RS00540	COG1217	gtp-binding protein TYPA
LK430_RS00545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LK430_RS00555	COG1024	Enoyl-CoA hydratase
LK430_RS00605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LK430_RS00615	COG0561	phosphatase activity
LK430_RS00635	COG0583	DNA-binding transcription factor activity
LK430_RS00645	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LK430_RS00665	COG0805	protein transport
LK430_RS00670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LK430_RS00700	COG0656	L-ascorbic acid biosynthetic process
LK430_RS00705	COG0656	L-ascorbic acid biosynthetic process
LK430_RS00720	COG1979	alcohol dehydrogenase
LK430_RS00730	COG0583	DNA-binding transcription factor activity
LK430_RS00735	COG1773	rubredoxin
LK430_RS00740	COG0322	excinuclease ABC activity
LK430_RS00750	COG0556	nucleotide-excision repair
LK430_RS00760	COG1666	GTP binding
LK430_RS00765	COG2860	membrane
LK430_RS00770	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LK430_RS00780	COG4796	Type ii and iii secretion system protein
LK430_RS00790	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LK430_RS00795	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LK430_RS00800	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LK430_RS00805	COG0740	serine-type endopeptidase activity
LK430_RS00810	COG0544	peptidyl-prolyl cis-trans isomerase activity
LK430_RS00815	COG1115	amino acid carrier protein
LK430_RS00850	COG1216	Glycosyl transferase, family 2
LK430_RS00860	COG1442	glycosyl transferase family 8
LK430_RS00865	COG0463	Glycosyl transferase, family 2
LK430_RS00875	COG1611	Belongs to the LOG family
LK430_RS00890	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LK430_RS00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LK430_RS00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LK430_RS00910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK430_RS00920	COG0436	Aminotransferase
LK430_RS00925	COG0572	uridine kinase
LK430_RS00940	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LK430_RS00945	COG0606	chelatase, subunit chli
LK430_RS00950	COG0792	nuclease activity
LK430_RS00955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LK430_RS00965	COG0681	Belongs to the peptidase S26 family
LK430_RS00970	COG0335	large ribosomal subunit rRNA binding
LK430_RS00975	COG0336	Belongs to the RNA methyltransferase TrmD family
LK430_RS01000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LK430_RS01005	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LK430_RS01015	COG0352	thiamine-phosphate diphosphorylase activity
LK430_RS01020	COG0351	phosphomethylpyrimidine kinase
LK430_RS01035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LK430_RS01040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LK430_RS01045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LK430_RS01055	COG2190	(PTS) system
LK430_RS01060	COG1185	polyribonucleotide nucleotidyltransferase activity
LK430_RS01065	COG0822	iron-sulfur transferase activity
LK430_RS01070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LK430_RS01080	COG0719	Fe-S assembly protein
LK430_RS01085	COG0396	ATPase activity
LK430_RS01090	COG2610	gluconate transmembrane transporter activity
LK430_RS01120	COG0237	dephospho-CoA kinase activity
LK430_RS01125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK430_RS01135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK430_RS01140	COG1115	amino acid carrier protein
LK430_RS01145	COG1757	Na H antiporter
LK430_RS01150	COG0589	response to stress
LK430_RS01155	COG0589	response to stress
LK430_RS01160	COG0589	response to stress
LK430_RS01165	COG0589	response to stress
LK430_RS01170	COG0589	response to stress
LK430_RS01205	COG2131	deaminase
LK430_RS01210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LK430_RS01215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LK430_RS01220	COG4475	Protein of unknown function (DUF436)
LK430_RS01225	COG0698	ribose 5-phosphate isomerase
LK430_RS01230	COG0009	L-threonylcarbamoyladenylate synthase
LK430_RS01235	COG2890	protein-(glutamine-N5) methyltransferase activity
LK430_RS01240	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LK430_RS01245	COG3872	metal-dependent enzyme
LK430_RS01250	COG0254	rRNA binding
LK430_RS01260	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LK430_RS01265	COG1760	l-serine dehydratase
LK430_RS01270	COG1760	l-serine dehydratase
LK430_RS01280	COG2855	membrane
LK430_RS01295	COG0583	DNA-binding transcription factor activity
LK430_RS01300	COG3052	prosthetic group binding
LK430_RS01315	COG2851	Citrate transporter
LK430_RS01320	COG2851	Citrate transporter
LK430_RS01325	COG3103	Sh3 type 3 domain protein
LK430_RS01325	COG0366	Alpha amylase catalytic
LK430_RS01330	COG0297	glycogen (starch) synthase activity
LK430_RS01335	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LK430_RS01340	COG0058	SHG alpha-glucan phosphorylase activity
LK430_RS01345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LK430_RS01360	COG0285	dihydrofolate synthase activity
LK430_RS01365	COG0525	valine-tRNA ligase activity
LK430_RS01385	COG1827	regulation of RNA biosynthetic process
LK430_RS01450	COG1122	ATPase activity
LK430_RS01455	COG4771	TonB-dependent receptor
LK430_RS01460	COG2731	YhcH YjgK YiaL family protein
LK430_RS01485	COG1720	tRNA m6t6A37 methyltransferase activity
LK430_RS01500	COG1021	2,3-dihydroxybenzoate-AMP ligase
LK430_RS01505	COG0183	Belongs to the thiolase family
LK430_RS01510	COG1268	BioY protein
LK430_RS01520	COG0583	DNA-binding transcription factor activity
LK430_RS01525	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LK430_RS01530	COG1301	dicarboxylic acid transport
LK430_RS01540	COG3189	MarR family transcriptional regulator
LK430_RS01550	COG1151	hydroxylamine reductase activity
LK430_RS01565	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LK430_RS01570	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LK430_RS01585	COG1418	mRNA catabolic process
LK430_RS01595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LK430_RS01600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LK430_RS01610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK430_RS01610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LK430_RS01625	COG4206	TonB-dependent receptor
LK430_RS01630	COG0101	tRNA pseudouridine synthase activity
LK430_RS01635	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LK430_RS01640	COG1122	ATPase activity
LK430_RS01645	COG1122	ATPase activity
LK430_RS01650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LK430_RS01655	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LK430_RS01665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LK430_RS01670	COG0085	RNA polymerase activity
LK430_RS01680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LK430_RS01690	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LK430_RS01705	COG1177	transmembrane transport
LK430_RS01710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LK430_RS01720	COG0436	Aminotransferase
LK430_RS01725	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LK430_RS01735	COG1733	regulation of RNA biosynthetic process
LK430_RS01750	COG0798	PFAM Bile acid sodium symporter
LK430_RS01785	COG0848	biopolymer transport protein
LK430_RS01790	COG0811	peptide transport
LK430_RS01795	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LK430_RS01810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LK430_RS01815	COG1162	GTPase activity
LK430_RS01820	COG0515	serine threonine protein kinase
LK430_RS01820	COG2815	serine threonine protein kinase
LK430_RS01830	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LK430_RS01835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LK430_RS01835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LK430_RS01845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LK430_RS01855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LK430_RS01860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LK430_RS01865	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
LK430_RS01875	COG1592	Rubrerythrin
LK430_RS01875	COG1773	rubredoxin
LK430_RS01880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LK430_RS01880	COG1648	precorrin-2 dehydrogenase activity
LK430_RS01890	COG0181	hydroxymethylbilane synthase activity
LK430_RS01910	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LK430_RS01920	COG2195	Cleaves the N-terminal amino acid of tripeptides
LK430_RS01935	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LK430_RS01940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LK430_RS01940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LK430_RS01960	COG1316	TRANSCRIPTIONal
LK430_RS01965	COG0159	tryptophan synthase activity
LK430_RS01975	COG0135	phosphoribosylanthranilate isomerase activity
LK430_RS01980	COG0134	indole-3-glycerol-phosphate synthase activity
LK430_RS01990	COG0512	Glutamine amidotransferase of anthranilate synthase
LK430_RS01990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LK430_RS02025	COG0842	Transport permease protein
LK430_RS02030	COG0842	Transport permease protein
LK430_RS02035	COG1131	(ABC) transporter
LK430_RS02040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LK430_RS02045	COG1538	Outer membrane efflux protein
LK430_RS02060	COG2707	UPF0756 membrane protein
LK430_RS02065	COG1473	amidohydrolase
LK430_RS02075	COG2011	ABC-type metal ion transport system permease component
LK430_RS02080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LK430_RS02085	COG0222	ribosome binding
LK430_RS02090	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LK430_RS02095	COG0081	regulation of translation
LK430_RS02100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LK430_RS02105	COG0250	Participates in transcription elongation, termination and antitermination
LK430_RS02110	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LK430_RS02115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LK430_RS02120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LK430_RS02170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK430_RS02180	COG1115	amino acid carrier protein
LK430_RS02185	COG4178	(ABC) transporter
LK430_RS02195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LK430_RS02205	COG0277	FAD linked oxidase domain protein
LK430_RS02215	COG2056	Na+-H+ antiporter family
LK430_RS02220	COG2986	histidine ammonia-lyase
LK430_RS02225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LK430_RS02230	COG3829	transcription factor binding
LK430_RS02240	COG3404	Formiminotransferase-cyclodeaminase
LK430_RS02265	COG0577	efflux transmembrane transporter activity
LK430_RS02265	COG1136	(ABC) transporter
LK430_RS02270	COG1136	(ABC) transporter
LK430_RS02275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LK430_RS02280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LK430_RS02285	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LK430_RS02290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LK430_RS02315	COG1704	LemA family
LK430_RS02320	COG0786	glutamate:sodium symporter activity
LK430_RS02345	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LK430_RS02350	COG0010	Belongs to the arginase family
LK430_RS02355	COG1414	Transcriptional regulator
LK430_RS02360	COG0251	oxidation-reduction process
LK430_RS02365	COG3842	ATPase activity
LK430_RS02370	COG1176	ABC-type spermidine putrescine transport system, permease component I
LK430_RS02380	COG2084	Dehydrogenase
LK430_RS02390	COG0385	Bile acid
LK430_RS02395	COG1288	antiporter activity
LK430_RS02400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK430_RS02405	COG1346	cytolysis
LK430_RS02410	COG1380	Effector of murein hydrolase LrgA
LK430_RS02415	COG1027	Aspartate ammonia-lyase
LK430_RS02450	COG1114	Component of the transport system for branched-chain amino acids
LK430_RS02455	COG1028	Short-chain dehydrogenase reductase Sdr
LK430_RS02460	COG1278	Cold shock
LK430_RS02470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LK430_RS02480	COG0492	ferredoxin-NADP+ reductase activity
LK430_RS02495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK430_RS02500	COG1394	ATPase activity, coupled to movement of substances
LK430_RS02505	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
LK430_RS02510	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
LK430_RS02515	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
LK430_RS02530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LK430_RS02535	COG1269	ATP hydrolysis coupled proton transport
LK430_RS02545	COG2309	aminopeptidase activity
LK430_RS02550	COG1012	belongs to the aldehyde dehydrogenase family
LK430_RS02555	COG3384	dioxygenase
LK430_RS02560	COG0823	Involved in the tonB-independent uptake of proteins
LK430_RS02560	COG1506	peptidase
LK430_RS02560	COG4946	Tricorn protease homolog
LK430_RS02565	COG1695	Transcriptional regulator
LK430_RS02570	COG0739	heme binding
LK430_RS02575	COG0583	DNA-binding transcription factor activity
LK430_RS02600	COG2244	polysaccharide biosynthetic process
LK430_RS02605	COG1924	4 iron, 4 sulfur cluster binding
LK430_RS02610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LK430_RS02635	COG0440	acetolactate synthase activity
LK430_RS02640	COG0028	Belongs to the TPP enzyme family
LK430_RS02645	COG2205	protein histidine kinase activity
LK430_RS02650	COG0745	RESPONSE REGULATOR receiver
LK430_RS02655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LK430_RS02660	COG0028	Belongs to the TPP enzyme family
LK430_RS02665	COG0440	acetolactate synthase activity
LK430_RS02670	COG0519	Catalyzes the synthesis of GMP from XMP
LK430_RS02675	COG0473	3-isopropylmalate dehydrogenase activity
LK430_RS02680	COG0066	3-isopropylmalate dehydratase activity
LK430_RS02685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LK430_RS02695	COG0583	DNA-binding transcription factor activity
LK430_RS02720	COG2996	Protein conserved in bacteria
LK430_RS02725	COG0799	negative regulation of ribosome biogenesis
LK430_RS02730	COG1316	TRANSCRIPTIONal
LK430_RS02735	COG1713	HD superfamily hydrolase involved in NAD metabolism
LK430_RS02740	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LK430_RS02745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LK430_RS02750	COG0012	GTP binding
LK430_RS02760	COG1263	PTS System
LK430_RS02760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK430_RS02765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LK430_RS02780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LK430_RS02785	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LK430_RS02795	COG0277	FAD linked oxidase domain protein
LK430_RS02800	COG1966	Carbon starvation protein
LK430_RS02835	COG5002	protein histidine kinase activity
LK430_RS02865	COG0768	penicillin binding
LK430_RS02870	COG0772	Belongs to the SEDS family
LK430_RS02875	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LK430_RS02880	COG2204	response regulator
LK430_RS02895	COG4656	Part of a membrane complex involved in electron transport
LK430_RS02900	COG4658	electron transport chain
LK430_RS02905	COG4659	FMN binding
LK430_RS02910	COG4660	Part of a membrane complex involved in electron transport
LK430_RS02915	COG4657	Part of a membrane complex involved in electron transport
LK430_RS02920	COG2878	Part of a membrane complex involved in electron transport
LK430_RS02920	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
LK430_RS02950	COG3885	ferrous iron binding
LK430_RS02950	COG2078	PFAM AMMECR1 domain protein
LK430_RS02970	COG0642	Histidine kinase
LK430_RS02975	COG0745	RESPONSE REGULATOR receiver
LK430_RS02980	COG2851	Citrate transporter
LK430_RS02985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LK430_RS02990	COG0583	DNA-binding transcription factor activity
LK430_RS03000	COG1733	regulation of RNA biosynthetic process
LK430_RS03015	COG2205	protein histidine kinase activity
LK430_RS03020	COG0745	RESPONSE REGULATOR receiver
LK430_RS03030	COG0803	Belongs to the bacterial solute-binding protein 9 family
LK430_RS03035	COG1121	(ABC) transporter
LK430_RS03040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LK430_RS03045	COG0735	belongs to the Fur family
LK430_RS03050	COG1757	Na H antiporter
LK430_RS03055	COG2721	sulfolactate sulfo-lyase activity
LK430_RS03065	COG0427	acetyl-CoA hydrolase
LK430_RS03075	COG0129	dihydroxy-acid dehydratase activity
LK430_RS03085	COG1013	pyruvate-flavodoxin oxidoreductase activity
LK430_RS03090	COG0674	pyruvate-flavodoxin oxidoreductase activity
LK430_RS03090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LK430_RS03100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK430_RS03105	COG2610	gluconate transmembrane transporter activity
LK430_RS03110	COG4948	Mandelate Racemase Muconate Lactonizing
LK430_RS03115	COG0583	DNA-binding transcription factor activity
LK430_RS03125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK430_RS03140	COG2195	Cleaves the N-terminal amino acid of tripeptides
LK430_RS03150	COG2873	o-acetylhomoserine
LK430_RS03155	COG0697	spore germination
LK430_RS03160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LK430_RS03165	COG1971	Probably functions as a manganese efflux pump
LK430_RS03185	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LK430_RS03210	COG2116	formate transmembrane transporter activity
LK430_RS03220	COG1115	amino acid carrier protein
LK430_RS03235	COG0786	glutamate:sodium symporter activity
LK430_RS03255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LK430_RS03260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LK430_RS03265	COG0305	Participates in initiation and elongation during chromosome replication
LK430_RS03270	COG0359	binds to the 23S rRNA
LK430_RS03275	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LK430_RS03285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LK430_RS03295	COG0360	Binds together with S18 to 16S ribosomal RNA
LK430_RS03305	COG0482	sulfurtransferase activity
LK430_RS03315	COG3279	Response regulator of the LytR AlgR family
LK430_RS03340	COG1473	amidohydrolase
LK430_RS03345	COG1473	amidohydrolase
LK430_RS03350	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LK430_RS03405	COG0517	IMP dehydrogenase activity
LK430_RS03435	COG0281	malic enzyme
LK430_RS03440	COG0583	DNA-binding transcription factor activity
LK430_RS03450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LK430_RS03455	COG0730	response to heat
LK430_RS03465	COG0187	DNA topoisomerase II activity
LK430_RS03480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LK430_RS03485	COG0592	DNA-directed DNA polymerase activity
LK430_RS03490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LK430_RS03500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LK430_RS03505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LK430_RS03510	COG5001	Diguanylate cyclase
LK430_RS03510	COG3300	MHYT domain
LK430_RS03535	COG0252	asparaginase activity
LK430_RS03540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LK430_RS03550	COG1473	amidohydrolase
LK430_RS03565	COG0594	ribonuclease P activity
LK430_RS03570	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LK430_RS03580	COG1847	R3H domain protein
LK430_RS03585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LK430_RS03590	COG0445	tRNA wobble uridine modification
LK430_RS03595	COG0357	Ribosomal RNA small subunit methyltransferase G
LK430_RS03605	COG2195	Cleaves the N-terminal amino acid of tripeptides
LK430_RS03610	COG1192	Involved in chromosome partitioning
LK430_RS03615	COG1475	DNA binding
LK430_RS03645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK430_RS03665	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LK430_RS03675	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LK430_RS03690	COG3314	Sporulation integral membrane protein YlbJ
LK430_RS03695	COG0493	'glutamate synthase
LK430_RS03715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LK430_RS03720	COG0114	fumarate hydratase activity
LK430_RS03735	COG0071	Belongs to the small heat shock protein (HSP20) family
LK430_RS03750	COG1122	ATPase activity
LK430_RS03755	COG1122	ATPase activity
LK430_RS03765	COG2183	response to ionizing radiation
LK430_RS03770	COG2195	Cleaves the N-terminal amino acid of tripeptides
LK430_RS03815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK430_RS03825	COG0583	DNA-binding transcription factor activity
LK430_RS03830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LK430_RS03840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LK430_RS03845	COG0471	metal ion transport
LK430_RS03845	COG0490	domain, Protein
LK430_RS03870	COG0583	DNA-binding transcription factor activity
LK430_RS03905	COG4948	Mandelate Racemase Muconate Lactonizing
LK430_RS03910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LK430_RS03920	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
LK430_RS03930	COG0583	DNA-binding transcription factor activity
LK430_RS03945	COG1473	amidohydrolase
LK430_RS03955	COG1414	Transcriptional regulator
LK430_RS03965	COG0010	Belongs to the arginase family
LK430_RS03980	COG3842	ATPase activity
LK430_RS03985	COG1178	ABC-type Fe3 transport system permease component
LK430_RS03990	COG3842	ATPase activity
LK430_RS04005	COG2267	carboxylic ester hydrolase activity
LK430_RS04010	COG1301	dicarboxylic acid transport
LK430_RS04015	COG3829	transcription factor binding
LK430_RS04030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK430_RS04035	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
LK430_RS04040	COG0251	oxidation-reduction process
LK430_RS04050	COG1917	Cupin 2, conserved barrel domain protein
LK430_RS04050	COG2207	Transcriptional regulator
LK430_RS04055	COG0471	metal ion transport
LK430_RS04060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK430_RS04060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LK430_RS04065	COG0446	pyridine nucleotide-disulphide oxidoreductase
LK430_RS04075	COG0583	DNA-binding transcription factor activity
LK430_RS04080	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LK430_RS04085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
LK430_RS04085	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LK430_RS04090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK430_RS04100	COG0129	dihydroxy-acid dehydratase activity
LK430_RS04125	COG2828	Protein conserved in bacteria
LK430_RS04130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LK430_RS04135	COG0583	DNA-binding transcription factor activity
LK430_RS04140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LK430_RS04145	COG2706	6-phosphogluconolactonase activity
LK430_RS04155	COG0473	3-isopropylmalate dehydrogenase activity
LK430_RS04160	COG0583	DNA-binding transcription factor activity
LK430_RS04165	COG0583	DNA-binding transcription factor activity
LK430_RS04180	COG0735	belongs to the Fur family
LK430_RS04190	COG0542	response to heat
LK430_RS04205	COG0477	Major facilitator Superfamily
LK430_RS04205	COG0477	Major facilitator Superfamily
LK430_RS04210	COG2843	Capsule synthesis protein
LK430_RS04215	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LK430_RS04225	COG0493	'glutamate synthase
LK430_RS04230	COG1959	2 iron, 2 sulfur cluster binding
LK430_RS04270	COG0582	viral genome integration into host DNA
LK430_RS04300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LK430_RS04305	COG0488	(ABC) transporter
LK430_RS04330	COG1358	cellular component organization or biogenesis
LK430_RS04335	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LK430_RS04340	COG0049	tRNA binding
LK430_RS04350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LK430_RS04360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LK430_RS04365	COG0088	Forms part of the polypeptide exit tunnel
LK430_RS04370	COG0089	rRNA binding
LK430_RS04375	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LK430_RS04380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LK430_RS04385	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LK430_RS04390	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LK430_RS04395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LK430_RS04400	COG0255	Belongs to the universal ribosomal protein uL29 family
LK430_RS04405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LK430_RS04410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LK430_RS04415	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LK430_RS04425	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LK430_RS04430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LK430_RS04435	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LK430_RS04440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LK430_RS04445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LK430_RS04450	COG1841	ribosomal large subunit assembly
LK430_RS04455	COG0200	Binds to the 23S rRNA
LK430_RS04460	COG0201	protein transport
LK430_RS04465	COG0563	adenylate kinase activity
LK430_RS04475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LK430_RS04480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LK430_RS04490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LK430_RS04495	COG0202	RNA polymerase activity
LK430_RS04515	COG0622	Phosphoesterase
LK430_RS04535	COG0488	(ABC) transporter
LK430_RS04555	COG1982	Orn Lys Arg decarboxylase major
LK430_RS04560	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LK430_RS04565	COG0010	Belongs to the arginase family
LK430_RS04580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LK430_RS04585	COG0573	inorganic phosphate transmembrane transporter activity
LK430_RS04590	COG0573	inorganic phosphate transmembrane transporter activity
LK430_RS04595	COG0581	inorganic phosphate transmembrane transporter activity
LK430_RS04600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LK430_RS04605	COG0704	Plays a role in the regulation of phosphate uptake
LK430_RS04620	COG1136	(ABC) transporter
LK430_RS04645	COG0583	DNA-binding transcription factor activity
LK430_RS04650	COG1827	regulation of RNA biosynthetic process
LK430_RS04660	COG1914	H( )-stimulated, divalent metal cation uptake system
LK430_RS04665	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LK430_RS04670	COG1914	H( )-stimulated, divalent metal cation uptake system
LK430_RS04675	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LK430_RS04680	COG1984	allophanate hydrolase subunit 2
LK430_RS04685	COG2195	Cleaves the N-terminal amino acid of tripeptides
LK430_RS04690	COG2816	NAD+ diphosphatase activity
LK430_RS04695	COG1194	a g-specific adenine glycosylase
LK430_RS04725	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LK430_RS04730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK430_RS04750	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LK430_RS04760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LK430_RS04765	COG1687	branched-chain amino acid
LK430_RS04770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LK430_RS04775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK430_RS04780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LK430_RS04790	COG0646	methionine synthase
LK430_RS04790	COG1410	methionine synthase
LK430_RS04795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LK430_RS04800	COG0531	amino acid
LK430_RS04810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LK430_RS04815	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LK430_RS04840	COG2172	sigma factor antagonist activity
LK430_RS04850	COG0427	acetyl-CoA hydrolase
LK430_RS04855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK430_RS04865	COG4770	biotin carboxylase activity
LK430_RS04870	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
LK430_RS04890	COG0424	maF-like protein
LK430_RS04895	COG2003	Belongs to the UPF0758 family
LK430_RS04900	COG1077	Cell shape determining protein MreB Mrl
LK430_RS04920	COG0772	Belongs to the SEDS family
LK430_RS04935	COG1530	ribonuclease E activity
LK430_RS04940	COG0617	tRNA 3'-terminal CCA addition
LK430_RS04945	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LK430_RS04950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LK430_RS04955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LK430_RS04960	COG1924	4 iron, 4 sulfur cluster binding
LK430_RS04965	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
LK430_RS04970	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
LK430_RS04980	COG0427	acetyl-CoA hydrolase
LK430_RS04985	COG0583	DNA-binding transcription factor activity
LK430_RS04990	COG1288	antiporter activity
LK430_RS05000	COG1328	CTP reductase activity
LK430_RS05010	COG1473	amidohydrolase
LK430_RS05020	COG1607	acyl-coa hydrolase
LK430_RS05030	COG0733	neurotransmitter:sodium symporter activity
LK430_RS05035	COG0733	neurotransmitter:sodium symporter activity
LK430_RS05045	COG0561	phosphatase activity
LK430_RS05060	COG1045	serine acetyltransferase
LK430_RS05075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LK430_RS05080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK430_RS05085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LK430_RS05090	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
LK430_RS05120	COG4139	cobalamin transport
LK430_RS05130	COG0574	Belongs to the PEP-utilizing enzyme family
LK430_RS05130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK430_RS05135	COG0517	IMP dehydrogenase activity
LK430_RS05140	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LK430_RS05145	COG0305	Participates in initiation and elongation during chromosome replication
LK430_RS05145	COG0358	DNA primase activity
LK430_RS05165	COG0752	glycyl-tRNA synthetase alpha subunit
LK430_RS05170	COG0751	glycine-tRNA ligase activity
LK430_RS05180	COG3210	domain, Protein
LK430_RS05185	COG3210	domain, Protein
LK430_RS05230	COG3210	domain, Protein
LK430_RS05255	COG0473	3-isopropylmalate dehydrogenase activity
LK430_RS05260	COG0626	cystathionine gamma-synthase activity
LK430_RS05265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LK430_RS05270	COG0154	amidase activity
LK430_RS05275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LK430_RS05285	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LK430_RS05300	COG0514	ATP-dependent DNA helicase (RecQ)
LK430_RS05320	COG1827	regulation of RNA biosynthetic process
LK430_RS05335	COG1288	antiporter activity
LK430_RS05340	COG2195	Cleaves the N-terminal amino acid of tripeptides
LK430_RS05345	COG0583	DNA-binding transcription factor activity
LK430_RS05350	COG2721	sulfolactate sulfo-lyase activity
LK430_RS05355	COG2721	sulfolactate sulfo-lyase activity
LK430_RS05360	COG1301	dicarboxylic acid transport
LK430_RS05380	COG1247	-acetyltransferase
LK430_RS05385	COG0300	oxidoreductase activity
LK430_RS05410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LK430_RS05415	COG1408	metallophosphoesterase
LK430_RS05430	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LK430_RS05435	COG0590	tRNA wobble adenosine to inosine editing
LK430_RS05445	COG0277	FAD linked oxidase domain protein
LK430_RS05460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LK430_RS05465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LK430_RS05470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LK430_RS05490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LK430_RS05495	COG0534	Mate efflux family protein
LK430_RS05510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK430_RS05515	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LK430_RS05525	COG0356	it plays a direct role in the translocation of protons across the membrane
LK430_RS05530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LK430_RS05535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LK430_RS05540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LK430_RS05545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LK430_RS05570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LK430_RS05575	COG1077	Cell shape determining protein MreB Mrl
LK430_RS05580	COG5434	Belongs to the glycosyl hydrolase 28 family
LK430_RS05580	COG4632	Exopolysaccharide biosynthesis protein
LK430_RS05590	COG0750	zinc metalloprotease
LK430_RS05595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LK430_RS05600	COG1127	ABC transporter
LK430_RS05620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LK430_RS05640	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LK430_RS05655	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LK430_RS05655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LK430_RS05660	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LK430_RS05665	COG3494	Protein of unknown function (DUF1009)
LK430_RS05670	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LK430_RS05675	COG1132	(ABC) transporter
LK430_RS05680	COG1663	tetraacyldisaccharide 4'-kinase activity
LK430_RS05690	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LK430_RS05700	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LK430_RS05720	COG1137	ATPase activity
LK430_RS05740	COG4372	Transposase
LK430_RS05750	COG0497	DNA recombination
LK430_RS05755	COG0497	DNA recombination
LK430_RS05760	COG0497	DNA recombination
LK430_RS05765	COG0497	DNA recombination
LK430_RS05785	COG1739	Uncharacterized protein family UPF0029
LK430_RS05805	COG2990	Protein conserved in bacteria
LK430_RS05820	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LK430_RS05825	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LK430_RS05825	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LK430_RS05830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LK430_RS05835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LK430_RS05880	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LK430_RS05895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LK430_RS05905	COG0602	queuosine metabolic process
LK430_RS05910	COG0419	ATPase involved in DNA repair
LK430_RS05915	COG0420	3'-5' exonuclease activity
LK430_RS05920	COG0501	Belongs to the peptidase M48B family
LK430_RS05940	COG4120	Belongs to the binding-protein-dependent transport system permease family
LK430_RS05960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LK430_RS05965	COG0736	holo-[acyl-carrier-protein] synthase activity
LK430_RS05970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LK430_RS05970	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LK430_RS05975	COG0860	N-Acetylmuramoyl-L-alanine amidase
LK430_RS05985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK430_RS05995	COG0018	arginyl-trna synthetase
LK430_RS06000	COG0504	CTP synthase activity
LK430_RS06005	COG1494	fructose-1,6-bisphosphatase
LK430_RS06010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LK430_RS06015	COG2244	polysaccharide biosynthetic process
LK430_RS06020	COG3956	TIGRFAM MazG family protein
LK430_RS06025	COG0776	regulation of translation
LK430_RS06035	COG0489	protein tyrosine kinase activity
LK430_RS06045	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LK430_RS06050	COG0287	Prephenate dehydrogenase
LK430_RS06055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LK430_RS06060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LK430_RS06065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LK430_RS06070	COG0077	Prephenate dehydratase
LK430_RS06070	COG1605	Chorismate mutase
LK430_RS06075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LK430_RS06080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LK430_RS06085	COG0668	transmembrane transport
LK430_RS06090	COG2379	hydroxypyruvate reductase
LK430_RS06110	COG2217	Heavy metal translocating P-type atpase
LK430_RS06115	COG1098	S1 RNA binding domain
LK430_RS06120	COG0037	tRNA processing
LK430_RS06125	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LK430_RS06130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK430_RS06140	COG1268	BioY protein
LK430_RS06145	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LK430_RS06150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LK430_RS06160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK430_RS06165	COG4948	Mandelate Racemase Muconate Lactonizing
LK430_RS06185	COG3584	3D domain protein
LK430_RS06185	COG1388	LysM domain
LK430_RS06195	COG1960	acyl-CoA dehydrogenase activity
LK430_RS06200	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LK430_RS06205	COG0802	atpase or kinase
LK430_RS06210	COG1214	PFAM Peptidase M22, glycoprotease
LK430_RS06230	COG0426	domain, Protein
LK430_RS06235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LK430_RS06245	COG0583	DNA-binding transcription factor activity
LK430_RS06265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LK430_RS06310	COG0024	Methionine aminopeptidase
LK430_RS06325	COG4536	flavin adenine dinucleotide binding
LK430_RS06330	COG1451	nucleotide metabolic process
LK430_RS06345	COG3279	Response regulator of the LytR AlgR family
LK430_RS06375	COG0798	PFAM Bile acid sodium symporter
LK430_RS06380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK430_RS06420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LK430_RS06425	COG1464	Belongs to the NlpA lipoprotein family
LK430_RS06445	COG1592	Rubrerythrin
LK430_RS06450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LK430_RS06465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LK430_RS06465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LK430_RS06480	COG0217	transcriptional regulatory protein
LK430_RS06485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LK430_RS06490	COG0632	four-way junction helicase activity
LK430_RS06495	COG2255	four-way junction helicase activity
LK430_RS06500	COG2247	cell wall binding repeat
LK430_RS06500	COG2385	sporulation resulting in formation of a cellular spore
LK430_RS06505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LK430_RS06515	COG1862	Preprotein translocase
LK430_RS06525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK430_RS06530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LK430_RS06545	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LK430_RS06545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LK430_RS06550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK430_RS06555	COG1490	D-aminoacyl-tRNA deacylase activity
LK430_RS06560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK430_RS06565	COG0628	permease
LK430_RS06570	COG0124	histidyl-tRNA synthetase
LK430_RS06575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LK430_RS06600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LK430_RS06605	COG0564	pseudouridine synthase activity
LK430_RS06610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LK430_RS06615	COG1196	nuclear chromosome segregation
LK430_RS06620	COG0552	protein localization to endoplasmic reticulum
LK430_RS06650	COG1304	FMN binding
LK430_RS06655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LK430_RS06660	COG0569	domain protein
LK430_RS06665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK430_RS06670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LK430_RS06675	COG1937	Protein conserved in bacteria
LK430_RS06700	COG0492	ferredoxin-NADP+ reductase activity
LK430_RS06715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LK430_RS06720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LK430_RS06730	COG2848	UPF0210 protein
LK430_RS06735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LK430_RS06750	COG0183	Belongs to the thiolase family
LK430_RS06760	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK430_RS06765	COG1024	Enoyl-CoA hydratase
LK430_RS06775	COG1362	aminopeptidase activity
LK430_RS06785	COG0280	phosphate acetyltransferase
LK430_RS06805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LK430_RS06820	COG1132	(ABC) transporter
LK430_RS06835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LK430_RS06840	COG1811	Na channel or pump
LK430_RS06850	COG0784	Response regulator, receiver
LK430_RS06850	COG3437	response regulator, receiver
LK430_RS06855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK430_RS06870	COG1555	photosystem II stabilization
LK430_RS06870	COG1596	polysaccharide export
LK430_RS06885	COG0786	glutamate:sodium symporter activity
LK430_RS06890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LK430_RS06895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LK430_RS06900	COG1802	Transcriptional regulator
LK430_RS06905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LK430_RS06910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LK430_RS06915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LK430_RS06920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LK430_RS06930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LK430_RS06940	COG3706	GGDEF domain
LK430_RS06955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK430_RS06955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK430_RS06960	COG0084	hydrolase, TatD family'
LK430_RS06965	COG3584	3D domain protein
LK430_RS06965	COG1388	LysM domain
LK430_RS06975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LK430_RS06985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LK430_RS06990	COG0459	protein refolding
LK430_RS06995	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LK430_RS07000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LK430_RS07015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK430_RS07015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK430_RS07025	COG0129	dihydroxy-acid dehydratase activity
LK430_RS07040	COG1561	YicC-like family, N-terminal region
LK430_RS07045	COG2052	Domain of unknown function (DUF370)
LK430_RS07050	COG0194	GDP metabolic process
LK430_RS07055	COG1758	RNA polymerase activity
LK430_RS07060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LK430_RS07080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LK430_RS07100	COG1473	amidohydrolase
LK430_RS07140	COG0742	ribosomal rna small subunit methyltransferase
LK430_RS07145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LK430_RS07155	COG1323	Belongs to the UPF0348 family
LK430_RS07160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LK430_RS07170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LK430_RS07175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LK430_RS07180	COG2030	dehydratase
LK430_RS07185	COG0416	fatty acid biosynthetic process
LK430_RS07190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK430_RS07195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LK430_RS07200	COG1028	Short-chain dehydrogenase reductase Sdr
LK430_RS07205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK430_RS07215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK430_RS07220	COG0571	ribonuclease III activity
LK430_RS07225	COG2199	diguanylate cyclase activity
LK430_RS07225	COG2203	Gaf domain
LK430_RS07235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LK430_RS07245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LK430_RS07250	COG0052	Belongs to the universal ribosomal protein uS2 family
LK430_RS07255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LK430_RS07260	COG0528	UMP kinase activity
LK430_RS07265	COG0233	cytoplasmic translational termination
LK430_RS07280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LK430_RS07285	COG0575	Belongs to the CDS family
LK430_RS07290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LK430_RS07295	COG0750	zinc metalloprotease
LK430_RS07300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LK430_RS07305	COG0442	prolyl-tRNA aminoacylation
LK430_RS07310	COG1285	pathogenesis
LK430_RS07320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK430_RS07325	COG1115	amino acid carrier protein
LK430_RS07340	COG2040	homocysteine
LK430_RS07350	COG1473	amidohydrolase
LK430_RS07360	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LK430_RS07365	COG0779	Required for maturation of 30S ribosomal subunits
LK430_RS07370	COG0195	Participates in both transcription termination and antitermination
LK430_RS07375	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LK430_RS07385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LK430_RS07385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LK430_RS07390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LK430_RS07395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LK430_RS07400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LK430_RS07405	COG0196	riboflavin kinase activity
LK430_RS07410	COG0268	Binds directly to 16S ribosomal RNA
LK430_RS07415	COG0481	GTPase activity
LK430_RS07425	COG1802	Transcriptional regulator
LK430_RS07430	COG0471	metal ion transport
LK430_RS07435	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LK430_RS07440	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LK430_RS07465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LK430_RS07480	COG1234	tRNA 3'-trailer cleavage
LK430_RS07485	COG0037	tRNA processing
LK430_RS07500	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LK430_RS07505	COG1074	ATP-dependent DNA helicase activity
LK430_RS07515	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LK430_RS07520	COG0402	S-adenosylhomocysteine deaminase activity
LK430_RS07530	COG0493	'glutamate synthase
LK430_RS07540	COG3047	cAMP biosynthetic process
LK430_RS07540	COG2885	chlorophyll binding
LK430_RS07565	COG1061	Type III restriction enzyme res subunit
LK430_RS07575	COG0540	Belongs to the ATCase OTCase family
LK430_RS07580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK430_RS07585	COG0505	Belongs to the CarA family
LK430_RS07590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LK430_RS07595	COG0543	2 iron, 2 sulfur cluster binding
LK430_RS07600	COG0167	dihydroorotate dehydrogenase activity
LK430_RS07605	COG0284	orotidine-5'-phosphate decarboxylase activity
LK430_RS07610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LK430_RS07620	COG2001	Belongs to the MraZ family
LK430_RS07625	COG0275	rRNA processing
LK430_RS07640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LK430_RS07645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK430_RS07655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LK430_RS07660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LK430_RS07665	COG1181	Belongs to the D-alanine--D-alanine ligase family
LK430_RS07680	COG3856	small basic protein
LK430_RS07685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LK430_RS07750	COG3706	GGDEF domain
LK430_RS07750	COG4251	negative regulation of phosphorylation
LK430_RS07750	COG5001	Diguanylate cyclase
LK430_RS07750	COG2203	Gaf domain
LK430_RS07755	COG0826	peptidase U32
LK430_RS07760	COG1193	negative regulation of DNA recombination
LK430_RS07770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LK430_RS07775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LK430_RS07780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LK430_RS07785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LK430_RS07790	COG0138	bifunctional purine biosynthesis protein purh
LK430_RS07795	COG0151	Belongs to the GarS family
LK430_RS07800	COG0517	IMP dehydrogenase activity
LK430_RS07800	COG0516	GMP reductase activity
LK430_RS07810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LK430_RS07820	COG2239	Acts as a magnesium transporter
LK430_RS07825	COG0385	Bile acid
LK430_RS07830	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LK430_RS07840	COG0534	Mate efflux family protein
LK430_RS07865	COG1360	Flagellar Motor Protein
LK430_RS07875	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK430_RS07900	COG1047	Peptidyl-prolyl cis-trans
LK430_RS07915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LK430_RS07920	COG0758	DNA mediated transformation
LK430_RS07925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LK430_RS07930	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LK430_RS07935	COG4974	Belongs to the 'phage' integrase family
LK430_RS07945	COG1994	Peptidase M50
LK430_RS07955	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LK430_RS07960	COG1187	pseudouridine synthase activity
LK430_RS07965	COG2081	HI0933 family
LK430_RS07970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LK430_RS07980	COG0539	negative regulation of cytoplasmic translation
LK430_RS07980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LK430_RS07985	COG1304	FMN binding
LK430_RS07995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LK430_RS08000	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LK430_RS08005	COG4492	Belongs to the UPF0735 family
LK430_RS08010	COG0460	homoserine dehydrogenase
LK430_RS08015	COG0083	homoserine kinase activity
LK430_RS08020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LK430_RS08025	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LK430_RS08035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LK430_RS08040	COG0720	synthase
LK430_RS08045	COG1469	GTP cyclohydrolase I activity
LK430_RS08050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LK430_RS08055	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LK430_RS08055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LK430_RS08090	COG1484	DNA-dependent DNA replication
LK430_RS08110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK430_RS08115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LK430_RS08120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LK430_RS08130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LK430_RS08135	COG1923	regulation of RNA biosynthetic process
LK430_RS08140	COG4974	Belongs to the 'phage' integrase family
LK430_RS08150	COG0786	glutamate:sodium symporter activity
LK430_RS08160	COG1328	CTP reductase activity
LK430_RS08160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LK430_RS08175	COG2033	superoxide reductase activity
LK430_RS08180	COG0352	thiamine-phosphate diphosphorylase activity
LK430_RS08190	COG0756	dUTP diphosphatase activity
LK430_RS08205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LK430_RS08210	COG0527	aspartate kinase activity
LK430_RS08215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK430_RS08235	COG4964	Belongs to the GSP D family
LK430_RS08240	COG0489	protein tyrosine kinase activity
LK430_RS08280	COG2011	ABC-type metal ion transport system permease component
LK430_RS08285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LK430_RS08290	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LK430_RS08295	COG1522	sequence-specific DNA binding
LK430_RS08305	COG0732	type I restriction modification DNA specificity domain
LK430_RS08315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LK430_RS08345	COG0640	Transcriptional regulator
LK430_RS08380	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
LK430_RS08440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LK430_RS08565	COG0860	N-Acetylmuramoyl-L-alanine amidase
LK430_RS08655	COG0494	nUDIX hydrolase
LK430_RS08680	COG2186	Transcriptional regulator
LK430_RS08700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LK430_RS08800	COG1475	DNA binding
LK430_RS08835	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
LK430_RS08850	COG2851	Citrate transporter
LK430_RS08865	COG2081	HI0933 family
LK430_RS08900	COG0484	heat shock protein binding
LK430_RS08935	COG2020	methyltransferase activity
LK430_RS08975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK430_RS08980	COG0583	DNA-binding transcription factor activity
LK430_RS08990	COG1132	(ABC) transporter
LK430_RS09010	COG3579	cysteine-type endopeptidase activity
LK430_RS09015	COG0531	amino acid
LK430_RS09020	COG1362	aminopeptidase activity
LK430_RS09025	COG0039	L-malate dehydrogenase activity
LK430_RS09030	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LK430_RS09035	COG3394	polysaccharide catabolic process
LK430_RS09040	COG1105	Belongs to the carbohydrate kinase PfkB family
LK430_RS09045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK430_RS09045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK430_RS09045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK430_RS09065	COG2814	Major facilitator Superfamily
LK430_RS09080	COG0613	PHP domain protein
LK430_RS09090	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LK430_RS09105	COG2358	TRAP transporter, solute receptor (TAXI family
LK430_RS09110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LK430_RS09115	COG1674	ftsk spoiiie
LK430_RS09120	COG1426	Protein conserved in bacteria
LK430_RS09125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK430_RS09130	COG1546	Belongs to the CinA family
LK430_RS09130	COG1058	Belongs to the CinA family
LK430_RS09135	COG0513	Belongs to the DEAD box helicase family
LK430_RS09140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LK430_RS09145	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LK430_RS09150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LK430_RS09155	COG1301	dicarboxylic acid transport
LK430_RS09160	COG0785	Cytochrome C biogenesis protein
LK430_RS09165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK430_RS09175	COG1122	ATPase activity
LK430_RS09185	COG0310	cobalt ion transport
LK430_RS09190	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
LK430_RS09195	COG1691	(AIR) carboxylase
LK430_RS09200	COG1606	tRNA processing
LK430_RS09205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LK430_RS09210	COG0564	pseudouridine synthase activity
LK430_RS09215	COG0191	fructose-bisphosphate aldolase activity
LK430_RS09220	COG1309	transcriptional regulator
LK430_RS09235	COG1773	rubredoxin
LK430_RS09235	COG1592	Rubrerythrin
LK430_RS09280	COG2176	DNA-directed DNA polymerase activity
LK430_RS09285	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
LK430_RS09290	COG2086	electron transfer activity
LK430_RS09310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LK430_RS09315	COG1799	cell septum assembly
LK430_RS09335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LK430_RS09345	COG0557	exoribonuclease II activity
LK430_RS09380	COG0583	DNA-binding transcription factor activity
LK430_RS09395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK430_RS09400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LK430_RS09405	COG1309	transcriptional regulator
LK430_RS09410	COG0242	peptide deformylase activity
LK430_RS09440	COG2814	Major facilitator Superfamily
LK430_RS09445	COG0583	DNA-binding transcription factor activity
LK430_RS09470	COG0242	peptide deformylase activity
LK430_RS09480	COG2814	Major facilitator Superfamily
LK430_RS09505	COG0673	inositol 2-dehydrogenase activity
LK430_RS09510	COG5002	protein histidine kinase activity
LK430_RS09515	COG0745	RESPONSE REGULATOR receiver
LK430_RS09520	COG2357	RelA SpoT domain protein
LK430_RS09525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LK430_RS09530	COG0148	phosphopyruvate hydratase activity
LK430_RS09540	COG0126	phosphoglycerate kinase activity
LK430_RS09540	COG0149	triose-phosphate isomerase activity
LK430_RS09560	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LK430_RS09565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LK430_RS09570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LK430_RS09575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK430_RS09580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LK430_RS09580	COG0140	phosphoribosyl-ATP diphosphatase activity
LK430_RS09585	COG0107	imidazoleglycerol-phosphate synthase activity
LK430_RS09590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LK430_RS09595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LK430_RS09600	COG0131	Imidazoleglycerol-phosphate dehydratase
LK430_RS09605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LK430_RS09620	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LK430_RS09625	COG4496	protein, YerC YecD
LK430_RS09635	COG0583	DNA-binding transcription factor activity
LK430_RS09640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LK430_RS09655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LK430_RS09665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LK430_RS09685	COG0406	alpha-ribazole phosphatase activity
LK430_RS09690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LK430_RS09695	COG0006	proline dipeptidase activity
LK430_RS09700	COG0826	peptidase U32
LK430_RS09705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LK430_RS09710	COG3906	Belongs to the UPF0473 family
LK430_RS09715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LK430_RS09720	COG4472	Bacterial protein of unknown function (DUF965)
LK430_RS09735	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LK430_RS09785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK430_RS09785	COG0072	phenylalanine-tRNA ligase activity
LK430_RS09790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LK430_RS09800	COG1132	(ABC) transporter
LK430_RS09805	COG1132	(ABC) transporter
LK430_RS09835	COG2217	Heavy metal translocating P-type atpase
LK430_RS09875	COG2199	diguanylate cyclase activity
LK430_RS09875	COG2202	Pas domain
LK430_RS09875	COG2200	EAL domain
LK430_RS09885	COG0534	Mate efflux family protein
LK430_RS09890	COG0371	Dehydrogenase
LK430_RS09920	COG1116	anion transmembrane transporter activity
LK430_RS09930	COG2359	stage V sporulation protein S
LK430_RS09935	COG0494	nUDIX hydrolase
LK430_RS09940	COG0497	DNA recombination
LK430_RS09950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LK430_RS09955	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LK430_RS09960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LK430_RS09970	COG1722	exodeoxyribonuclease VII activity
LK430_RS09975	COG1570	exodeoxyribonuclease VII activity
LK430_RS09985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LK430_RS10000	COG1302	Protein conserved in bacteria
LK430_RS10045	COG0737	Belongs to the 5'-nucleotidase family
LK430_RS10055	COG2197	response regulator
LK430_RS10060	COG3850	Histidine kinase
LK430_RS10070	COG0318	PFAM AMP-dependent synthetase and ligase
LK430_RS10075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LK430_RS10080	COG1970	mechanosensitive ion channel activity
LK430_RS10090	COG0697	spore germination
LK430_RS10100	COG3679	Belongs to the UPF0342 family
LK430_RS10110	COG5002	protein histidine kinase activity
LK430_RS10115	COG0745	RESPONSE REGULATOR receiver
LK430_RS10125	COG1388	LysM domain
LK430_RS10125	COG0791	NLP P60 protein
LK430_RS10125	COG3103	Sh3 type 3 domain protein
LK430_RS10130	COG0463	Glycosyl transferase, family 2
LK430_RS10145	COG3481	metal-dependent phosphohydrolase, HD sub domain
LK430_RS10150	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LK430_RS10155	COG2384	SAM-dependent methyltransferase
LK430_RS10160	COG0515	serine threonine protein kinase
LK430_RS10170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK430_RS10175	COG0640	Transcriptional regulator
LK430_RS10190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK430_RS10195	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LK430_RS10210	COG5001	Diguanylate cyclase
LK430_RS10210	COG2203	Gaf domain
LK430_RS10210	COG3706	GGDEF domain
LK430_RS10210	COG4251	negative regulation of phosphorylation
LK430_RS10260	COG0564	pseudouridine synthase activity
LK430_RS10265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK430_RS10270	COG1464	Belongs to the NlpA lipoprotein family
LK430_RS10280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LK430_RS10290	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK430_RS10295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LK430_RS10305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LK430_RS10325	COG0765	amino acid transport
LK430_RS10330	COG0765	amino acid transport
LK430_RS10335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LK430_RS10340	COG1126	abc transporter atp-binding protein
LK430_RS10345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LK430_RS10350	COG0385	Bile acid
LK430_RS10365	COG1215	transferase activity, transferring glycosyl groups
LK430_RS10375	COG0688	phosphatidylethanolamine metabolic process
LK430_RS10380	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LK430_RS10385	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LK430_RS10410	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
LK430_RS10415	COG1518	maintenance of DNA repeat elements
LK430_RS10485	COG1216	Glycosyl transferase, family 2
LK430_RS10485	COG1442	glycosyl transferase family 8
LK430_RS10490	COG1216	Glycosyl transferase, family 2
LK430_RS10495	COG1216	Glycosyl transferase, family 2
LK430_RS10495	COG1442	glycosyl transferase family 8
LK430_RS10500	COG1088	dTDP-glucose 4,6-dehydratase activity
LK430_RS10510	COG3475	LICD family
LK430_RS10575	COG0562	UDP-galactopyranose mutase
LK430_RS10645	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LK430_RS10650	COG0215	cysteine-tRNA ligase activity
LK430_RS10655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK430_RS10670	COG4956	integral membrane protein (PIN domain superfamily)
LK430_RS10685	COG0436	Aminotransferase
LK430_RS10690	COG1610	YqeY-like protein
LK430_RS10700	COG0537	adenosine 5'-monophosphoramidase activity
LK430_RS10705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LK430_RS10710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LK430_RS10715	COG2264	protein methyltransferase activity
LK430_RS10735	COG0484	heat shock protein binding
LK430_RS10740	COG0443	Heat shock 70 kDa protein
LK430_RS10745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LK430_RS10750	COG1420	regulation of RNA biosynthetic process
LK430_RS10755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LK430_RS10760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LK430_RS10765	COG0471	metal ion transport
LK430_RS10795	COG0281	malic enzyme
LK430_RS10805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LK430_RS10830	COG1959	2 iron, 2 sulfur cluster binding
LK430_RS10850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LK430_RS10860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LK430_RS10870	COG1473	amidohydrolase
LK430_RS10875	COG0534	Mate efflux family protein
LK430_RS10910	COG0519	Catalyzes the synthesis of GMP from XMP
LK430_RS10955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LK430_RS10960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LK430_RS10965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LK430_RS10975	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LK430_RS10980	COG0784	Response regulator, receiver
LK430_RS10980	COG2198	Histidine kinase
LK430_RS10980	COG2205	protein histidine kinase activity
LK430_RS10985	COG0793	Belongs to the peptidase S41A family
LK430_RS10995	COG2177	Part of the ABC transporter FtsEX involved in
LK430_RS11000	COG2884	Cell division ATP-binding protein ftsE
LK430_RS11040	COG1115	amino acid carrier protein
LK430_RS11050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LK430_RS11050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity