locus-tag	class	description
D1866_RS00030	COG0501	Belongs to the peptidase M48B family
D1866_RS00060	COG0477	Major facilitator Superfamily
D1866_RS00075	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D1866_RS00095	COG1592	Rubrerythrin
D1866_RS00125	COG0450	alkyl hydroperoxide reductase
D1866_RS00135	COG1215	transferase activity, transferring glycosyl groups
D1866_RS00145	COG0352	thiamine-phosphate diphosphorylase activity
D1866_RS00145	COG0351	phosphomethylpyrimidine kinase
D1866_RS00150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1866_RS00155	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1866_RS00175	COG1234	tRNA 3'-trailer cleavage
D1866_RS00200	COG0463	Glycosyl transferase, family 2
D1866_RS00205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D1866_RS00220	COG1063	alcohol dehydrogenase
D1866_RS00240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D1866_RS00240	COG0519	Catalyzes the synthesis of GMP from XMP
D1866_RS00245	COG0501	Belongs to the peptidase M48B family
D1866_RS00250	COG0516	GMP reductase activity
D1866_RS00250	COG0517	IMP dehydrogenase activity
D1866_RS00265	COG1830	Aldolase
D1866_RS00285	COG0405	Gamma-glutamyltransferase
D1866_RS00300	COG1444	tRNA N-acetyltransferase activity
D1866_RS00320	COG0589	response to stress
D1866_RS00335	COG0864	Transcriptional regulator
D1866_RS00345	COG0460	homoserine dehydrogenase
D1866_RS00350	COG0109	protoheme IX farnesyltransferase activity
D1866_RS00360	COG1024	Enoyl-CoA hydratase
D1866_RS00400	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1866_RS00410	COG0189	ligase activity
D1866_RS00415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1866_RS00425	COG0165	Argininosuccinate lyase
D1866_RS00430	COG0137	argininosuccinate synthase activity
D1866_RS00445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1866_RS00450	COG0151	Belongs to the GarS family
D1866_RS00455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1866_RS00460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1866_RS00465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1866_RS00470	COG0047	phosphoribosylformylglycinamidine synthase activity
D1866_RS00480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1866_RS00485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1866_RS00485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1866_RS00490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1866_RS00530	COG0284	orotidine-5'-phosphate decarboxylase activity
D1866_RS00535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1866_RS00540	COG0540	Belongs to the ATCase OTCase family
D1866_RS00545	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
D1866_RS00560	COG0167	dihydroorotate dehydrogenase activity
D1866_RS00575	COG2095	MarC family integral membrane protein
D1866_RS00580	COG1522	sequence-specific DNA binding
D1866_RS00595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1866_RS00600	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D1866_RS00605	COG2151	metal-sulfur cluster biosynthetic enzyme
D1866_RS00615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1866_RS00625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1866_RS00630	COG0107	imidazoleglycerol-phosphate synthase activity
D1866_RS00645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D1866_RS00650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1866_RS00660	COG0495	leucyl-tRNA aminoacylation
D1866_RS00665	COG2096	Adenosyltransferase
D1866_RS00670	COG0037	tRNA processing
D1866_RS00680	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D1866_RS00695	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1866_RS00705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D1866_RS00710	COG0546	phosphoglycolate phosphatase activity
D1866_RS00715	COG0028	Belongs to the TPP enzyme family
D1866_RS00740	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D1866_RS00745	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D1866_RS00755	COG0442	prolyl-tRNA aminoacylation
D1866_RS00780	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
D1866_RS00800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1866_RS00830	COG0417	DNA replication proofreading
D1866_RS00850	COG1260	myo-inositol-1-phosphate synthase
D1866_RS00860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1866_RS00865	COG0713	ATP synthesis coupled electron transport
D1866_RS00875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1866_RS00880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D1866_RS00885	COG0649	NAD binding
D1866_RS00890	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1866_RS00920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1866_RS00955	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D1866_RS00970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D1866_RS00975	COG0083	homoserine kinase activity
D1866_RS00985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D1866_RS00990	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D1866_RS00995	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D1866_RS01000	COG1605	Chorismate mutase
D1866_RS01000	COG0077	Prephenate dehydratase
D1866_RS01005	COG3958	Transketolase
D1866_RS01010	COG3959	Transketolase, thiamine diphosphate binding domain
D1866_RS01045	COG0539	negative regulation of cytoplasmic translation
D1866_RS01085	COG0067	glutamate synthase
D1866_RS01090	COG0069	glutamate synthase activity
D1866_RS01115	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D1866_RS01175	COG1185	polyribonucleotide nucleotidyltransferase activity
D1866_RS01215	COG0300	oxidoreductase activity
D1866_RS01250	COG0535	radical SAM domain protein
D1866_RS01255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D1866_RS01260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1866_RS01260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D1866_RS01270	COG0318	PFAM AMP-dependent synthetase and ligase
D1866_RS01295	COG0302	gtp cyclohydrolase
D1866_RS01305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1866_RS01320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1866_RS01385	COG0552	protein localization to endoplasmic reticulum
D1866_RS01400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D1866_RS01420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1866_RS01435	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D1866_RS01440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1866_RS01460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1866_RS01470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1866_RS01475	COG0126	phosphoglycerate kinase activity
D1866_RS01540	COG0396	ATPase activity
D1866_RS01560	COG0509	glycine decarboxylation via glycine cleavage system
D1866_RS01565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D1866_RS01570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1866_RS01575	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D1866_RS01610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1866_RS01615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1866_RS01630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1866_RS01670	COG0525	valine-tRNA ligase activity
D1866_RS01675	COG0436	Aminotransferase
D1866_RS01680	COG0134	indole-3-glycerol-phosphate synthase activity
D1866_RS01685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D1866_RS01685	COG0512	Glutamine amidotransferase of anthranilate synthase
D1866_RS01690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1866_RS01695	COG0135	phosphoribosylanthranilate isomerase activity
D1866_RS01705	COG0159	tryptophan synthase activity
D1866_RS01710	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
D1866_RS01715	COG1254	Belongs to the acylphosphatase family
D1866_RS01730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1866_RS01730	COG0574	Belongs to the PEP-utilizing enzyme family
D1866_RS01745	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1866_RS01755	COG0527	aspartate kinase activity
D1866_RS01760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1866_RS01775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D1866_RS01810	COG0459	protein refolding
D1866_RS01835	COG0018	arginyl-trna synthetase
D1866_RS01870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1866_RS01875	COG0252	asparaginase activity
D1866_RS01905	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
D1866_RS01955	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D1866_RS01955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D1866_RS01970	COG0154	amidase activity
D1866_RS01980	COG1324	tolerance protein
D1866_RS01990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1866_RS02015	COG1110	DNA topoisomerase II activity
D1866_RS02025	COG0514	ATP-dependent DNA helicase (RecQ)
D1866_RS02055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D1866_RS02060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1866_RS02070	COG2084	Dehydrogenase
D1866_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
D1866_RS02090	COG0528	UMP kinase activity
D1866_RS02100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1866_RS02220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1866_RS02220	COG0426	domain, Protein
D1866_RS02265	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1866_RS02270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1866_RS02280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1866_RS02285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D1866_RS02325	COG0004	ammonium transporteR
D1866_RS02360	COG0438	transferase activity, transferring glycosyl groups
D1866_RS02370	COG0589	response to stress
D1866_RS02395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D1866_RS02405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1866_RS02420	COG0045	succinate-CoA ligase (ADP-forming) activity
D1866_RS02440	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D1866_RS02445	COG1078	dGTPase activity
D1866_RS02480	COG1832	CoA-binding protein
D1866_RS02485	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1866_RS02505	COG0530	calcium, potassium:sodium antiporter activity
D1866_RS02515	COG3386	PFAM SMP-30 Gluconolaconase
D1866_RS02525	COG1695	Transcriptional regulator
D1866_RS02570	COG2814	Major facilitator Superfamily
D1866_RS02575	COG1335	isochorismatase
D1866_RS02600	COG1733	regulation of RNA biosynthetic process
D1866_RS02915	COG0813	purine-nucleoside phosphorylase activity
D1866_RS02920	COG0730	response to heat
D1866_RS02925	COG0531	amino acid
D1866_RS02950	COG0535	radical SAM domain protein
D1866_RS02955	COG0535	radical SAM domain protein
D1866_RS02975	COG0243	molybdopterin cofactor binding
D1866_RS03025	COG1373	ATPase (AAA superfamily
D1866_RS03035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1866_RS03155	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1866_RS03180	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D1866_RS03220	COG1914	H( )-stimulated, divalent metal cation uptake system
D1866_RS03225	COG2814	Major facilitator Superfamily
D1866_RS03230	COG0589	response to stress
D1866_RS03275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1866_RS03295	COG0477	Major facilitator Superfamily
D1866_RS03325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1866_RS03350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1866_RS03420	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1866_RS03440	COG0731	radical SAM domain protein
D1866_RS03445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1866_RS03465	COG0778	Nitroreductase
D1866_RS03485	COG0095	Lipoate-protein ligase
D1866_RS03495	COG0509	glycine decarboxylation via glycine cleavage system
D1866_RS03500	COG0095	Lipoate-protein ligase
D1866_RS03505	COG0509	glycine decarboxylation via glycine cleavage system
D1866_RS03530	COG2048	Heterodisulfide reductase, subunit B
D1866_RS03545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1866_RS03560	COG0425	Belongs to the sulfur carrier protein TusA family
D1866_RS03565	COG2210	Belongs to the sulfur carrier protein TusA family
D1866_RS03645	COG2271	Major facilitator Superfamily
D1866_RS03690	COG0531	amino acid
D1866_RS03695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1866_RS03720	COG1131	(ABC) transporter
D1866_RS03775	COG1401	restriction endodeoxyribonuclease activity
D1866_RS03885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D1866_RS03900	COG1175	transmembrane transport
D1866_RS03925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1866_RS03985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1866_RS04050	COG1720	tRNA m6t6A37 methyltransferase activity
D1866_RS04080	COG0708	Exodeoxyribonuclease III
D1866_RS04095	COG0602	queuosine metabolic process
D1866_RS04140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1866_RS04195	COG1968	undecaprenyl-diphosphatase activity
D1866_RS04240	COG1489	DNA binding
D1866_RS04250	COG0656	L-ascorbic acid biosynthetic process
D1866_RS04285	COG3842	ATPase activity
D1866_RS04375	COG0531	amino acid
D1866_RS04435	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D1866_RS04445	COG3387	PFAM Glycoside hydrolase 15-related
D1866_RS04620	COG2271	Major facilitator Superfamily
D1866_RS04695	COG0308	aminopeptidase N
D1866_RS04745	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1866_RS04750	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1866_RS04765	COG0531	amino acid
D1866_RS04770	COG2814	Major facilitator Superfamily
D1866_RS04775	COG0277	FAD linked oxidase domain protein
D1866_RS04875	COG1373	ATPase (AAA superfamily
D1866_RS04940	COG1131	(ABC) transporter
D1866_RS04960	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D1866_RS05025	COG4139	cobalamin transport
D1866_RS05030	COG1121	(ABC) transporter
D1866_RS05085	COG3383	formate dehydrogenase (NAD+) activity
D1866_RS05140	COG1131	(ABC) transporter
D1866_RS05155	COG0071	Belongs to the small heat shock protein (HSP20) family
D1866_RS05160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1866_RS05275	COG2860	membrane
D1866_RS05280	COG0697	spore germination
D1866_RS05335	COG1042	CoA-binding domain protein
D1866_RS05335	COG0045	succinate-CoA ligase (ADP-forming) activity
D1866_RS05335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1866_RS05340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1866_RS05345	COG0531	amino acid
D1866_RS05350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1866_RS05355	COG1063	alcohol dehydrogenase
D1866_RS05365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1866_RS05385	COG1129	ABC transporter
D1866_RS05400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D1866_RS05405	COG0066	3-isopropylmalate dehydratase activity
D1866_RS05410	COG0778	Nitroreductase
D1866_RS05450	COG0708	Exodeoxyribonuclease III
D1866_RS05465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1866_RS05490	COG0157	Belongs to the NadC ModD family
D1866_RS05495	COG0519	Catalyzes the synthesis of GMP from XMP
D1866_RS05505	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1866_RS05535	COG1515	deoxyribonuclease V activity
D1866_RS05540	COG1335	isochorismatase
D1866_RS05550	COG0450	alkyl hydroperoxide reductase
D1866_RS05565	COG0372	Belongs to the citrate synthase family
D1866_RS05585	COG4581	dead DEAH box helicase
D1866_RS05595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1866_RS05605	COG0439	Biotin carboxylase
D1866_RS05650	COG0601	transmembrane transport
D1866_RS05655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D1866_RS05665	COG0756	dUTP diphosphatase activity
D1866_RS05705	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1866_RS05710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D1866_RS05725	COG0569	domain protein
D1866_RS05725	COG0189	ligase activity
D1866_RS05730	COG1522	sequence-specific DNA binding
D1866_RS05745	COG1446	asparaginase
D1866_RS05780	COG0647	UMP catabolic process
D1866_RS05785	COG1053	succinate dehydrogenase
D1866_RS05795	COG2048	Heterodisulfide reductase, subunit B
D1866_RS05805	COG2304	oxidoreductase activity
D1866_RS05810	COG0714	Associated with various cellular activities
D1866_RS05825	COG0303	'Molybdopterin
D1866_RS05830	COG0083	homoserine kinase activity
D1866_RS05835	COG0626	cystathionine gamma-synthase activity
D1866_RS05875	COG0183	Belongs to the thiolase family
D1866_RS05880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1866_RS05900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D1866_RS05915	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D1866_RS05930	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D1866_RS05935	COG0351	phosphomethylpyrimidine kinase
D1866_RS05970	COG1131	(ABC) transporter
D1866_RS06000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1866_RS06030	COG0720	synthase
D1866_RS06045	COG0492	ferredoxin-NADP+ reductase activity
D1866_RS06055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1866_RS06070	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D1866_RS06075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1866_RS06075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1866_RS06080	COG0346	lactoylglutathione lyase activity
D1866_RS06085	COG0071	Belongs to the small heat shock protein (HSP20) family
D1866_RS06110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1866_RS06130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1866_RS06130	COG1648	precorrin-2 dehydrogenase activity
D1866_RS06165	COG0174	glutamine synthetase
D1866_RS06170	COG1063	alcohol dehydrogenase
D1866_RS06175	COG0430	RNA-3'-phosphate cyclase activity
D1866_RS06185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1866_RS06190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1866_RS06195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1866_RS06205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1866_RS06300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1866_RS06305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1866_RS06325	COG0456	acetyltransferase
D1866_RS06330	COG0469	pyruvate kinase activity
D1866_RS06340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1866_RS06360	COG0297	glycogen (starch) synthase activity
D1866_RS06390	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1866_RS06395	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1866_RS06410	COG1122	ATPase activity
D1866_RS06435	COG1122	ATPase activity
D1866_RS06520	COG1063	alcohol dehydrogenase
D1866_RS06540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1866_RS06545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1866_RS06545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D1866_RS06600	COG0735	belongs to the Fur family
D1866_RS06620	COG0517	IMP dehydrogenase activity
D1866_RS06620	COG0617	tRNA 3'-terminal CCA addition
D1866_RS06620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1866_RS06630	COG2062	phosphohistidine phosphatase, SixA
D1866_RS06645	COG3118	belongs to the thioredoxin family
D1866_RS06700	COG0492	ferredoxin-NADP+ reductase activity
D1866_RS06710	COG2814	Major facilitator Superfamily
D1866_RS06715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D1866_RS06735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1866_RS06745	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D1866_RS06765	COG0561	phosphatase activity
D1866_RS06775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1866_RS06780	COG0537	adenosine 5'-monophosphoramidase activity
D1866_RS06790	COG0494	nUDIX hydrolase
D1866_RS06795	COG3253	May function as heme-dependent peroxidase
D1866_RS06810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1866_RS06815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1866_RS06815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1866_RS06875	COG0538	isocitrate dehydrogenase activity
D1866_RS06890	COG2154	pterin-4-alpha-carbinolamine dehydratase
D1866_RS06915	COG0330	HflC and HflK could
D1866_RS06940	COG0308	aminopeptidase N
D1866_RS06975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1866_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
D1866_RS06985	COG1331	Highly conserved protein containing a thioredoxin domain
D1866_RS07025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D1866_RS07030	COG0438	transferase activity, transferring glycosyl groups
D1866_RS07050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1866_RS07055	COG1024	Enoyl-CoA hydratase
D1866_RS07100	COG1252	NADH dehydrogenase
D1866_RS07110	COG1192	Involved in chromosome partitioning
D1866_RS07125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1866_RS07130	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D1866_RS07140	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D1866_RS07190	COG1205	dead DEAH box helicase
D1866_RS07190	COG1111	helicase
D1866_RS07215	COG0438	transferase activity, transferring glycosyl groups
D1866_RS07245	COG0463	Glycosyl transferase, family 2
D1866_RS07245	COG1216	Glycosyl transferase, family 2
D1866_RS07290	COG2226	methyltransferase
D1866_RS07295	COG0477	Major facilitator Superfamily
D1866_RS07310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1866_RS07310	COG0301	tRNA thio-modification
D1866_RS07340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1866_RS07345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1866_RS07355	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1866_RS07360	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1866_RS07400	COG4555	ABC transporter
D1866_RS07450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D1866_RS07530	COG0823	Involved in the tonB-independent uptake of proteins
D1866_RS07530	COG4946	Tricorn protease homolog
D1866_RS07530	COG1506	peptidase
D1866_RS07540	COG1573	uracil-dna glycosylase
D1866_RS07580	COG0586	Pfam SNARE associated Golgi protein
D1866_RS07605	COG1028	Short-chain dehydrogenase reductase Sdr
D1866_RS07630	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D1866_RS07630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1866_RS07685	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D1866_RS07690	COG3387	PFAM Glycoside hydrolase 15-related
D1866_RS07700	COG4948	Mandelate Racemase Muconate Lactonizing
D1866_RS07705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1866_RS07770	COG0409	Hydrogenase expression formation protein
D1866_RS07805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1866_RS07830	COG2009	succinate dehydrogenase
D1866_RS07860	COG2226	methyltransferase
D1866_RS07875	COG0243	molybdopterin cofactor binding
D1866_RS07915	COG2239	Acts as a magnesium transporter
D1866_RS07970	COG0535	radical SAM domain protein
D1866_RS07980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1866_RS07985	COG1120	ATPase activity
D1866_RS07990	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D1866_RS08035	COG0719	Fe-S assembly protein
D1866_RS08045	COG1215	transferase activity, transferring glycosyl groups
D1866_RS08075	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D1866_RS08100	COG0375	protein maturation
D1866_RS08160	COG0298	carbon dioxide binding
D1866_RS08165	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D1866_RS08190	COG1702	phosphate starvation-inducible protein PhoH
D1866_RS08330	COG2814	Major facilitator Superfamily
D1866_RS08355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1866_RS08375	COG0495	leucyl-tRNA aminoacylation
D1866_RS08405	COG0477	Major facilitator Superfamily
D1866_RS08410	COG0651	ATP synthesis coupled electron transport
D1866_RS08435	COG4608	Belongs to the ABC transporter superfamily
D1866_RS08445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1866_RS08470	COG0095	Lipoate-protein ligase
D1866_RS08575	COG2814	Major facilitator Superfamily
D1866_RS08585	COG2226	methyltransferase
D1866_RS08590	COG0531	amino acid
D1866_RS08610	COG1012	belongs to the aldehyde dehydrogenase family
D1866_RS08660	COG2723	6-phospho-beta-galactosidase activity
D1866_RS08675	COG1175	transmembrane transport
D1866_RS08680	COG3833	ABC-type maltose transport systems, permease component
D1866_RS08685	COG3842	ATPase activity
D1866_RS08695	COG0459	protein refolding
D1866_RS08710	COG1305	Transglutaminase-like
D1866_RS08715	COG2308	Evidence 4 Homologs of previously reported genes of
D1866_RS08750	COG1013	pyruvate-flavodoxin oxidoreductase activity
D1866_RS08755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D1866_RS08755	COG0674	pyruvate-flavodoxin oxidoreductase activity
D1866_RS08770	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1866_RS08770	COG0517	IMP dehydrogenase activity
D1866_RS08775	COG0372	Belongs to the citrate synthase family
D1866_RS08790	COG0039	L-malate dehydrogenase activity
D1866_RS09070	COG3189	MarR family transcriptional regulator
D1866_RS09100	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D1866_RS09105	COG1140	nitrate reductase beta subunit
D1866_RS09110	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D1866_RS09115	COG2181	nitrate reductase activity
D1866_RS09225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1866_RS09230	COG2271	Major facilitator Superfamily
D1866_RS09235	COG1953	Uracil, thiamine, allantoin
D1866_RS09240	COG2814	Major facilitator Superfamily
D1866_RS09245	COG1228	amidohydrolase
D1866_RS09250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D1866_RS09280	COG0601	transmembrane transport
D1866_RS09285	COG0444	Belongs to the ABC transporter superfamily
D1866_RS09290	COG4608	Belongs to the ABC transporter superfamily
D1866_RS09320	COG2814	Major facilitator Superfamily
D1866_RS09340	COG0531	amino acid
D1866_RS09345	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D1866_RS09350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1866_RS09355	COG0243	molybdopterin cofactor binding
D1866_RS09360	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1866_RS09420	COG0402	S-adenosylhomocysteine deaminase activity
D1866_RS09435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1866_RS09440	COG0601	transmembrane transport
D1866_RS09445	COG4608	Belongs to the ABC transporter superfamily
D1866_RS09455	COG1132	(ABC) transporter
D1866_RS09495	COG2002	toxin-antitoxin pair type II binding
D1866_RS09525	COG1373	ATPase (AAA superfamily
D1866_RS09605	COG0519	Catalyzes the synthesis of GMP from XMP
D1866_RS09610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1866_RS09615	COG0531	amino acid
D1866_RS09620	COG1473	amidohydrolase
D1866_RS09625	COG0402	S-adenosylhomocysteine deaminase activity
D1866_RS09635	COG0813	purine-nucleoside phosphorylase activity
D1866_RS09640	COG0832	Belongs to the urease beta subunit family
D1866_RS09640	COG0831	urea catabolic process
D1866_RS09650	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D1866_RS09660	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D1866_RS09665	COG0829	nickel cation binding
D1866_RS09675	COG0477	Major facilitator Superfamily
D1866_RS09680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1866_RS09690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1866_RS09720	COG0402	S-adenosylhomocysteine deaminase activity
D1866_RS09740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D1866_RS09785	COG1953	Uracil, thiamine, allantoin
D1866_RS09795	COG0167	dihydroorotate dehydrogenase activity
D1866_RS09800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D1866_RS09800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1866_RS09830	COG1505	serine-type exopeptidase activity
D1866_RS09840	COG1522	sequence-specific DNA binding
D1866_RS09845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1866_RS09870	COG0671	phosphoesterase, PA-phosphatase related
D1866_RS09885	COG0531	amino acid
D1866_RS09915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1866_RS09930	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D1866_RS09940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1866_RS09945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1866_RS09955	COG2062	phosphohistidine phosphatase, SixA
D1866_RS09980	COG1473	amidohydrolase
D1866_RS10005	COG0477	Major facilitator Superfamily
D1866_RS10060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1866_RS10085	COG1960	acyl-CoA dehydrogenase activity
D1866_RS10090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D1866_RS10125	COG2222	sugar isomerase
D1866_RS10130	COG0215	cysteine-tRNA ligase activity
D1866_RS10135	COG1051	belongs to the nudix hydrolase family
D1866_RS10145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D1866_RS10155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D1866_RS10165	COG1573	uracil-dna glycosylase
D1866_RS10195	COG0475	glutathione-regulated potassium exporter activity
D1866_RS10200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1866_RS10220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D1866_RS10255	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D1866_RS10260	COG1881	PFAM PEBP family protein
D1866_RS10270	COG2255	four-way junction helicase activity
D1866_RS10275	COG0315	cyclic pyranopterin monophosphate synthase activity
D1866_RS10330	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D1866_RS10355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1866_RS10360	COG1444	tRNA N-acetyltransferase activity
D1866_RS10380	COG0589	response to stress
D1866_RS10385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1866_RS10390	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D1866_RS10390	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D1866_RS10395	COG0009	L-threonylcarbamoyladenylate synthase
D1866_RS10400	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D1866_RS10405	COG2379	hydroxypyruvate reductase
D1866_RS10415	COG1321	iron dependent repressor
D1866_RS10435	COG2226	methyltransferase
D1866_RS10450	COG0303	'Molybdopterin
D1866_RS10455	COG0746	molybdenum cofactor guanylyltransferase activity
D1866_RS10470	COG0402	S-adenosylhomocysteine deaminase activity
D1866_RS10500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D1866_RS10545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1866_RS10560	COG1201	RNA secondary structure unwinding
D1866_RS10570	COG0617	tRNA 3'-terminal CCA addition
D1866_RS10570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D1866_RS10570	COG3620	sequence-specific DNA binding
D1866_RS10595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1866_RS10600	COG1546	Belongs to the CinA family
D1866_RS10600	COG1058	Belongs to the CinA family
D1866_RS10620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D1866_RS10625	COG0024	Methionine aminopeptidase
D1866_RS10650	COG0561	phosphatase activity
D1866_RS10655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1866_RS10695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1866_RS10715	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D1866_RS10720	COG0504	CTP synthase activity
D1866_RS10735	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
D1866_RS10765	COG2078	PFAM AMMECR1 domain protein
D1866_RS10780	COG0717	Belongs to the dCTP deaminase family
D1866_RS10785	COG1793	dna ligase
D1866_RS10795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1866_RS10820	COG0181	hydroxymethylbilane synthase activity
D1866_RS10825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1866_RS10830	COG0113	porphobilinogen synthase activity
D1866_RS10835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D1866_RS10840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1866_RS10840	COG1648	precorrin-2 dehydrogenase activity
D1866_RS10845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1866_RS10855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1866_RS10875	COG0585	pseudouridine synthase activity
D1866_RS10880	COG0017	Asparaginyl-tRNA synthetase
D1866_RS10900	COG0028	Belongs to the TPP enzyme family
D1866_RS10910	COG1396	sequence-specific DNA binding
D1866_RS10910	COG1917	Cupin 2, conserved barrel domain protein
D1866_RS10925	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1866_RS10930	COG0371	Dehydrogenase
D1866_RS10935	COG1047	Peptidyl-prolyl cis-trans
D1866_RS10940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D1866_RS10980	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D1866_RS10985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1866_RS11005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1866_RS11010	COG0142	geranyltranstransferase activity
D1866_RS11015	COG1304	FMN binding
D1866_RS11020	COG0528	UMP kinase activity
D1866_RS11030	COG1355	regulation of microtubule-based process
D1866_RS11035	COG0052	Belongs to the universal ribosomal protein uS2 family
D1866_RS11045	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D1866_RS11050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D1866_RS11055	COG0200	Binds to the 23S rRNA
D1866_RS11065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1866_RS11070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D1866_RS11075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1866_RS11095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1866_RS11105	COG0417	DNA replication proofreading
D1866_RS11135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D1866_RS11140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D1866_RS11155	COG3276	selenocysteine insertion sequence binding
D1866_RS11180	COG0010	Belongs to the arginase family
D1866_RS11185	COG0423	glycine-tRNA ligase activity
D1866_RS11215	COG0163	prenyltransferase activity
D1866_RS11220	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
D1866_RS11235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1866_RS11240	COG0515	serine threonine protein kinase
D1866_RS11240	COG2815	serine threonine protein kinase
D1866_RS11245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1866_RS11250	COG0667	Aldo Keto reductase
D1866_RS11295	COG1110	DNA topoisomerase II activity
D1866_RS11300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1866_RS11305	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
D1866_RS11320	COG0557	exoribonuclease II activity
D1866_RS11355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1866_RS11370	COG1797	cobyrinic acid a,c-diamide synthase activity
D1866_RS11395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D1866_RS11425	COG1201	RNA secondary structure unwinding
D1866_RS11435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1866_RS11440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D1866_RS11445	COG2813	Specifically methylates the guanine in position
D1866_RS11495	COG0051	transcription antitermination factor activity, RNA binding
D1866_RS11505	COG0049	tRNA binding
D1866_RS11530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1866_RS11535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1866_RS11540	COG0085	RNA polymerase activity
D1866_RS11550	COG0281	malic enzyme
D1866_RS11560	COG0105	UTP biosynthetic process
D1866_RS11575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1866_RS11585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D1866_RS11590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D1866_RS11600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1866_RS11605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1866_RS11610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1866_RS11620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1866_RS11635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1866_RS11640	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D1866_RS11645	COG1522	sequence-specific DNA binding
D1866_RS11650	COG1605	Chorismate mutase
D1866_RS11650	COG0077	Prephenate dehydratase
D1866_RS11690	COG1051	belongs to the nudix hydrolase family
D1866_RS11690	COG1056	cytidyltransferase-related domain
D1866_RS11695	COG1607	acyl-coa hydrolase
D1866_RS11750	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D1866_RS11770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D1866_RS11785	COG1129	ABC transporter
D1866_RS11790	COG1980	fructose-bisphosphate aldolase activity
D1866_RS11815	COG0459	protein refolding
D1866_RS11830	COG0124	histidyl-tRNA synthetase
D1866_RS11850	COG0343	queuine tRNA-ribosyltransferase activity
D1866_RS11865	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1866_RS11875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1866_RS11920	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D1866_RS11955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D1866_RS11960	COG2264	protein methyltransferase activity
D1866_RS11965	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1866_RS11975	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D1866_RS11980	COG0012	GTP binding
D1866_RS12020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1866_RS12025	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1866_RS12055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1866_RS12060	COG0546	phosphoglycolate phosphatase activity
D1866_RS12075	COG0473	3-isopropylmalate dehydrogenase activity
D1866_RS12080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D1866_RS12090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1866_RS12105	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1866_RS12110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1866_RS12115	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D1866_RS12120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D1866_RS12125	COG0255	Belongs to the universal ribosomal protein uL29 family
D1866_RS12140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1866_RS12145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1866_RS12155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1866_RS12165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D1866_RS12170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1866_RS12190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D1866_RS12205	COG0201	protein transport
D1866_RS12220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1866_RS12285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1866_RS12300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1866_RS12305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D1866_RS12320	COG0189	ligase activity
D1866_RS12325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1866_RS12330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1866_RS12335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1866_RS12355	COG0114	fumarate hydratase activity
D1866_RS12370	COG0516	GMP reductase activity
D1866_RS12370	COG0517	IMP dehydrogenase activity
D1866_RS12400	COG0149	triose-phosphate isomerase activity
D1866_RS12415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1866_RS12420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D1866_RS12450	COG2815	serine threonine protein kinase
D1866_RS12450	COG0515	serine threonine protein kinase
D1866_RS12475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1866_RS12475	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D1866_RS12480	COG0517	IMP dehydrogenase activity
D1866_RS12490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1866_RS12495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D1866_RS12500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D1866_RS12525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D1866_RS12550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D1866_RS12580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1866_RS12580	COG0543	2 iron, 2 sulfur cluster binding
D1866_RS12595	COG3264	Mechanosensitive ion channel
D1866_RS12595	COG1196	nuclear chromosome segregation
D1866_RS12625	COG0312	modulator of DNA gyrase
D1866_RS12645	COG0037	tRNA processing
D1866_RS12720	COG2409	Drug exporters of the RND superfamily
D1866_RS12745	COG0489	protein tyrosine kinase activity
D1866_RS12785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D1866_RS12795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D1866_RS12830	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D1866_RS12835	COG3830	Belongs to the UPF0237 family
D1866_RS12840	COG2848	UPF0210 protein
D1866_RS12850	COG0438	transferase activity, transferring glycosyl groups
D1866_RS12895	COG1584	GPR1 FUN34 yaaH family protein
D1866_RS12900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1866_RS12905	COG2814	Major facilitator Superfamily
D1866_RS12915	COG2814	Major facilitator Superfamily
D1866_RS12945	COG0438	transferase activity, transferring glycosyl groups
D1866_RS12980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1866_RS12990	COG1131	(ABC) transporter
D1866_RS13000	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine