locus-tag	class	description
DFR85_RS00055	COG0028	Belongs to the TPP enzyme family
DFR85_RS00060	COG1592	Rubrerythrin
DFR85_RS00090	COG0489	protein tyrosine kinase activity
DFR85_RS00120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DFR85_RS00140	COG2814	Major facilitator Superfamily
DFR85_RS00150	COG3547	Transposase (IS116 IS110 IS902 family)
DFR85_RS00170	COG2814	Major facilitator Superfamily
DFR85_RS00200	COG0243	molybdopterin cofactor binding
DFR85_RS00215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS00255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS00285	COG0730	response to heat
DFR85_RS00290	COG0813	purine-nucleoside phosphorylase activity
DFR85_RS00300	COG4555	ABC transporter
DFR85_RS00310	COG2814	Major facilitator Superfamily
DFR85_RS00315	COG1846	Transcriptional regulator
DFR85_RS00345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DFR85_RS00415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DFR85_RS00430	COG1131	(ABC) transporter
DFR85_RS00465	COG0823	Involved in the tonB-independent uptake of proteins
DFR85_RS00465	COG1506	peptidase
DFR85_RS00465	COG4946	Tricorn protease homolog
DFR85_RS00510	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
DFR85_RS00540	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DFR85_RS00545	COG0778	Nitroreductase
DFR85_RS00550	COG3830	Belongs to the UPF0237 family
DFR85_RS00555	COG2848	UPF0210 protein
DFR85_RS00610	COG0183	Belongs to the thiolase family
DFR85_RS00615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR85_RS00635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DFR85_RS00660	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DFR85_RS00670	COG0351	phosphomethylpyrimidine kinase
DFR85_RS00710	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DFR85_RS00720	COG1131	(ABC) transporter
DFR85_RS00770	COG0720	synthase
DFR85_RS00785	COG0492	ferredoxin-NADP+ reductase activity
DFR85_RS00815	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR85_RS00815	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR85_RS00820	COG0346	lactoylglutathione lyase activity
DFR85_RS00825	COG0071	Belongs to the small heat shock protein (HSP20) family
DFR85_RS00870	COG1648	precorrin-2 dehydrogenase activity
DFR85_RS00870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DFR85_RS00910	COG1063	alcohol dehydrogenase
DFR85_RS00915	COG0430	RNA-3'-phosphate cyclase activity
DFR85_RS00930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DFR85_RS00935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS00945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DFR85_RS00960	COG0535	radical SAM domain protein
DFR85_RS01045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DFR85_RS01065	COG0805	protein transport
DFR85_RS01095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DFR85_RS01115	COG0297	glycogen (starch) synthase activity
DFR85_RS01125	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DFR85_RS01150	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR85_RS01155	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DFR85_RS01205	COG1063	alcohol dehydrogenase
DFR85_RS01220	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
DFR85_RS01225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR85_RS01230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DFR85_RS01230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DFR85_RS01290	COG0735	belongs to the Fur family
DFR85_RS01310	COG0516	GMP reductase activity
DFR85_RS01310	COG0517	IMP dehydrogenase activity
DFR85_RS01335	COG3118	belongs to the thioredoxin family
DFR85_RS01345	COG1252	NADH dehydrogenase
DFR85_RS01400	COG0492	ferredoxin-NADP+ reductase activity
DFR85_RS01415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DFR85_RS01430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DFR85_RS01435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DFR85_RS01445	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DFR85_RS01465	COG0561	phosphatase activity
DFR85_RS01480	COG0537	adenosine 5'-monophosphoramidase activity
DFR85_RS01485	COG1335	isochorismatase
DFR85_RS01500	COG0494	nUDIX hydrolase
DFR85_RS01515	COG1573	uracil-dna glycosylase
DFR85_RS01525	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DFR85_RS01530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DFR85_RS01530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DFR85_RS01585	COG0538	isocitrate dehydrogenase activity
DFR85_RS01600	COG2154	pterin-4-alpha-carbinolamine dehydratase
DFR85_RS01605	COG2105	PFAM AIG2 family protein
DFR85_RS01625	COG0330	HflC and HflK could
DFR85_RS01690	COG0525	valine-tRNA ligase activity
DFR85_RS01730	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS01735	COG1331	Highly conserved protein containing a thioredoxin domain
DFR85_RS01775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR85_RS01775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DFR85_RS01780	COG0438	transferase activity, transferring glycosyl groups
DFR85_RS01805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS01825	COG1131	(ABC) transporter
DFR85_RS01870	COG1192	Involved in chromosome partitioning
DFR85_RS01905	COG0123	including yeast histone deacetylase and acetoin utilization protein
DFR85_RS01910	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DFR85_RS01955	COG1201	RNA secondary structure unwinding
DFR85_RS01965	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DFR85_RS01975	COG0243	molybdopterin cofactor binding
DFR85_RS02015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DFR85_RS02015	COG0596	Alpha beta hydrolase
DFR85_RS02015	COG2226	methyltransferase
DFR85_RS02025	COG2271	Major facilitator Superfamily
DFR85_RS02040	COG0301	tRNA thio-modification
DFR85_RS02045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DFR85_RS02055	COG0651	ATP synthesis coupled electron transport
DFR85_RS02060	COG0649	NAD binding
DFR85_RS02065	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR85_RS02070	COG0651	ATP synthesis coupled electron transport
DFR85_RS02075	COG0650	Formate hydrogenlyase subunit 4
DFR85_RS02120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR85_RS02135	COG0477	Major facilitator Superfamily
DFR85_RS02155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS02160	COG1012	belongs to the aldehyde dehydrogenase family
DFR85_RS02165	COG0243	molybdopterin cofactor binding
DFR85_RS02175	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS02180	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS02180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DFR85_RS02205	COG0463	Glycosyl transferase, family 2
DFR85_RS02210	COG3386	PFAM SMP-30 Gluconolaconase
DFR85_RS02255	COG2226	methyltransferase
DFR85_RS02290	COG0601	transmembrane transport
DFR85_RS02295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR85_RS02300	COG0444	Belongs to the ABC transporter superfamily
DFR85_RS02340	COG2308	Evidence 4 Homologs of previously reported genes of
DFR85_RS02360	COG1473	amidohydrolase
DFR85_RS02375	COG0531	amino acid
DFR85_RS02430	COG0531	amino acid
DFR85_RS02435	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS02440	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS02455	COG0588	phosphoglycerate mutase activity
DFR85_RS02465	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR85_RS02470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR85_RS02515	COG0804	urea catabolic process
DFR85_RS02520	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DFR85_RS02525	COG0830	nickel cation binding
DFR85_RS02530	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DFR85_RS02540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR85_RS02570	COG1131	(ABC) transporter
DFR85_RS02575	COG0823	Involved in the tonB-independent uptake of proteins
DFR85_RS02575	COG1506	peptidase
DFR85_RS02575	COG4946	Tricorn protease homolog
DFR85_RS02580	COG4152	abc transporter atp-binding protein
DFR85_RS02640	COG0601	transmembrane transport
DFR85_RS02645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR85_RS02650	COG0444	Belongs to the ABC transporter superfamily
DFR85_RS02655	COG4608	Belongs to the ABC transporter superfamily
DFR85_RS02710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DFR85_RS02715	COG0531	amino acid
DFR85_RS02740	COG2002	toxin-antitoxin pair type II binding
DFR85_RS02750	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DFR85_RS02790	COG0402	S-adenosylhomocysteine deaminase activity
DFR85_RS02805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DFR85_RS02825	COG4638	Rieske (2fe-2S)
DFR85_RS02835	COG0477	Major facilitator Superfamily
DFR85_RS02840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DFR85_RS02845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DFR85_RS02860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DFR85_RS02860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DFR85_RS02865	COG0167	dihydroorotate dehydrogenase activity
DFR85_RS02875	COG1953	Uracil, thiamine, allantoin
DFR85_RS02895	COG1953	Uracil, thiamine, allantoin
DFR85_RS02905	COG0243	molybdopterin cofactor binding
DFR85_RS02970	COG1228	amidohydrolase
DFR85_RS02975	COG2814	Major facilitator Superfamily
DFR85_RS03005	COG0531	amino acid
DFR85_RS03010	COG0519	Catalyzes the synthesis of GMP from XMP
DFR85_RS03020	COG2723	6-phospho-beta-galactosidase activity
DFR85_RS03025	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DFR85_RS03055	COG0731	radical SAM domain protein
DFR85_RS03105	COG1741	Belongs to the pirin family
DFR85_RS03125	COG0308	aminopeptidase N
DFR85_RS03140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR85_RS03155	COG0501	Belongs to the peptidase M48B family
DFR85_RS03165	COG3842	ATPase activity
DFR85_RS03170	COG1175	transmembrane transport
DFR85_RS03200	COG3547	Transposase (IS116 IS110 IS902 family)
DFR85_RS03330	COG0644	oxidoreductase
DFR85_RS03430	COG0243	molybdopterin cofactor binding
DFR85_RS03475	COG0535	radical SAM domain protein
DFR85_RS03485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DFR85_RS03490	COG1120	ATPase activity
DFR85_RS03540	COG2226	methyltransferase
DFR85_RS03550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DFR85_RS03610	COG0516	GMP reductase activity
DFR85_RS03670	COG0719	Fe-S assembly protein
DFR85_RS03705	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DFR85_RS03760	COG1575	Belongs to the MenA family. Type 1 subfamily
DFR85_RS03800	COG0409	Hydrogenase expression formation protein
DFR85_RS03810	COG0309	Hydrogenase expression formation protein (HypE)
DFR85_RS03895	COG1131	(ABC) transporter
DFR85_RS03925	COG0375	protein maturation
DFR85_RS03980	COG1373	ATPase (AAA superfamily
DFR85_RS03985	COG0459	protein refolding
DFR85_RS03995	COG0673	inositol 2-dehydrogenase activity
DFR85_RS04005	COG0675	Transposase, IS605 OrfB family
DFR85_RS04055	COG0667	Aldo Keto reductase
DFR85_RS04085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DFR85_RS04135	COG0601	transmembrane transport
DFR85_RS04140	COG0444	Belongs to the ABC transporter superfamily
DFR85_RS04145	COG4608	Belongs to the ABC transporter superfamily
DFR85_RS04150	COG4608	Belongs to the ABC transporter superfamily
DFR85_RS04165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR85_RS04200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DFR85_RS04205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DFR85_RS04270	COG1215	transferase activity, transferring glycosyl groups
DFR85_RS04280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DFR85_RS04285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DFR85_RS04290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DFR85_RS04295	COG1215	transferase activity, transferring glycosyl groups
DFR85_RS04305	COG0438	transferase activity, transferring glycosyl groups
DFR85_RS04400	COG1215	transferase activity, transferring glycosyl groups
DFR85_RS04415	COG0297	glycogen (starch) synthase activity
DFR85_RS04475	COG0531	amino acid
DFR85_RS04530	COG2815	serine threonine protein kinase
DFR85_RS04530	COG0515	serine threonine protein kinase
DFR85_RS04605	COG0515	serine threonine protein kinase
DFR85_RS04605	COG2815	serine threonine protein kinase
DFR85_RS04810	COG1373	ATPase (AAA superfamily
DFR85_RS04960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DFR85_RS04965	COG1216	Glycosyl transferase, family 2
DFR85_RS04965	COG1442	glycosyl transferase family 8
DFR85_RS05000	COG1216	Glycosyl transferase, family 2
DFR85_RS05145	COG0438	transferase activity, transferring glycosyl groups
DFR85_RS05165	COG0438	transferase activity, transferring glycosyl groups
DFR85_RS05180	COG0864	Transcriptional regulator
DFR85_RS05185	COG2217	Heavy metal translocating P-type atpase
DFR85_RS05245	COG1968	undecaprenyl-diphosphatase activity
DFR85_RS05295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DFR85_RS05300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR85_RS05325	COG0037	tRNA processing
DFR85_RS05345	COG0513	Belongs to the DEAD box helicase family
DFR85_RS05380	COG0475	glutathione-regulated potassium exporter activity
DFR85_RS05415	COG4946	Tricorn protease homolog
DFR85_RS05415	COG0793	Belongs to the peptidase S41A family
DFR85_RS05440	COG0095	Lipoate-protein ligase
DFR85_RS05445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR85_RS05490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DFR85_RS05520	COG0477	Major facilitator Superfamily
DFR85_RS05540	COG3264	Mechanosensitive ion channel
DFR85_RS05540	COG1196	nuclear chromosome segregation
DFR85_RS05565	COG0671	phosphoesterase, PA-phosphatase related
DFR85_RS05585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DFR85_RS05590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DFR85_RS05645	COG0708	Exodeoxyribonuclease III
DFR85_RS05665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DFR85_RS05675	COG3387	PFAM Glycoside hydrolase 15-related
DFR85_RS05735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS05740	COG2271	Major facilitator Superfamily
DFR85_RS05760	COG1121	(ABC) transporter
DFR85_RS05765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DFR85_RS05795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DFR85_RS05800	COG0066	3-isopropylmalate dehydratase activity
DFR85_RS05805	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DFR85_RS05815	COG1515	deoxyribonuclease V activity
DFR85_RS05830	COG0450	alkyl hydroperoxide reductase
DFR85_RS05845	COG0372	Belongs to the citrate synthase family
DFR85_RS05875	COG4581	dead DEAH box helicase
DFR85_RS05880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DFR85_RS05890	COG0439	Biotin carboxylase
DFR85_RS05900	COG1116	anion transmembrane transporter activity
DFR85_RS05910	COG0513	Belongs to the DEAD box helicase family
DFR85_RS05930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DFR85_RS05940	COG0601	transmembrane transport
DFR85_RS05945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DFR85_RS05970	COG0756	dUTP diphosphatase activity
DFR85_RS06005	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DFR85_RS06010	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DFR85_RS06030	COG1522	sequence-specific DNA binding
DFR85_RS06035	COG0644	oxidoreductase
DFR85_RS06045	COG1446	asparaginase
DFR85_RS06060	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DFR85_RS06080	COG1053	succinate dehydrogenase
DFR85_RS06100	COG2304	oxidoreductase activity
DFR85_RS06105	COG0714	Associated with various cellular activities
DFR85_RS06120	COG0303	'Molybdopterin
DFR85_RS06130	COG0626	cystathionine gamma-synthase activity
DFR85_RS06185	COG0446	pyridine nucleotide-disulphide oxidoreductase
DFR85_RS06220	COG1584	GPR1 FUN34 yaaH family protein
DFR85_RS06225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS06260	COG1444	tRNA N-acetyltransferase activity
DFR85_RS06270	COG2814	Major facilitator Superfamily
DFR85_RS06275	COG0589	response to stress
DFR85_RS06280	COG1131	(ABC) transporter
DFR85_RS06310	COG1444	tRNA N-acetyltransferase activity
DFR85_RS06320	COG0405	Gamma-glutamyltransferase
DFR85_RS06335	COG1215	transferase activity, transferring glycosyl groups
DFR85_RS06345	COG0351	phosphomethylpyrimidine kinase
DFR85_RS06350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DFR85_RS06355	COG1234	tRNA 3'-trailer cleavage
DFR85_RS06395	COG0463	Glycosyl transferase, family 2
DFR85_RS06415	COG1063	alcohol dehydrogenase
DFR85_RS06420	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DFR85_RS06435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DFR85_RS06435	COG0519	Catalyzes the synthesis of GMP from XMP
DFR85_RS06440	COG0501	Belongs to the peptidase M48B family
DFR85_RS06445	COG0517	IMP dehydrogenase activity
DFR85_RS06445	COG0516	GMP reductase activity
DFR85_RS06465	COG1830	Aldolase
DFR85_RS06490	COG2860	membrane
DFR85_RS06525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DFR85_RS06545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DFR85_RS06550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR85_RS06555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DFR85_RS06560	COG0189	ligase activity
DFR85_RS06575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DFR85_RS06580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DFR85_RS06600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DFR85_RS06640	COG0028	Belongs to the TPP enzyme family
DFR85_RS06665	COG0017	Asparaginyl-tRNA synthetase
DFR85_RS06670	COG0585	pseudouridine synthase activity
DFR85_RS06690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS06700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DFR85_RS06700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DFR85_RS06705	COG1648	precorrin-2 dehydrogenase activity
DFR85_RS06705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DFR85_RS06710	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DFR85_RS06715	COG0113	porphobilinogen synthase activity
DFR85_RS06720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR85_RS06725	COG0181	hydroxymethylbilane synthase activity
DFR85_RS06750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DFR85_RS06760	COG1793	dna ligase
DFR85_RS06765	COG0717	Belongs to the dCTP deaminase family
DFR85_RS06810	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
DFR85_RS06825	COG0504	CTP synthase activity
DFR85_RS06850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DFR85_RS06860	COG0492	ferredoxin-NADP+ reductase activity
DFR85_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS06910	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DFR85_RS06915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DFR85_RS06970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DFR85_RS06995	COG0200	Binds to the 23S rRNA
DFR85_RS07005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DFR85_RS07030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DFR85_RS07040	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DFR85_RS07055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DFR85_RS07070	COG0255	Belongs to the universal ribosomal protein uL29 family
DFR85_RS07075	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DFR85_RS07080	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DFR85_RS07085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DFR85_RS07090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DFR85_RS07095	COG0089	rRNA binding
DFR85_RS07100	COG0088	Forms part of the polypeptide exit tunnel
DFR85_RS07105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DFR85_RS07120	COG0473	3-isopropylmalate dehydrogenase activity
DFR85_RS07135	COG0546	phosphoglycolate phosphatase activity
DFR85_RS07140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DFR85_RS07145	COG0322	excinuclease ABC activity
DFR85_RS07175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DFR85_RS07180	COG1185	polyribonucleotide nucleotidyltransferase activity
DFR85_RS07215	COG0012	GTP binding
DFR85_RS07220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DFR85_RS07230	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DFR85_RS07235	COG2264	protein methyltransferase activity
DFR85_RS07240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DFR85_RS07285	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DFR85_RS07310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DFR85_RS07315	COG0371	Dehydrogenase
DFR85_RS07320	COG1047	Peptidyl-prolyl cis-trans
DFR85_RS07330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DFR85_RS07335	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DFR85_RS07365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DFR85_RS07375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS07390	COG0343	queuine tRNA-ribosyltransferase activity
DFR85_RS07410	COG0124	histidyl-tRNA synthetase
DFR85_RS07450	COG1980	fructose-bisphosphate aldolase activity
DFR85_RS07455	COG1121	(ABC) transporter
DFR85_RS07535	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DFR85_RS07590	COG1056	cytidyltransferase-related domain
DFR85_RS07590	COG1051	belongs to the nudix hydrolase family
DFR85_RS07605	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DFR85_RS07605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR85_RS07630	COG0077	Prephenate dehydratase
DFR85_RS07630	COG1605	Chorismate mutase
DFR85_RS07640	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DFR85_RS07660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DFR85_RS07675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DFR85_RS07680	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DFR85_RS07690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DFR85_RS07695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFR85_RS07700	COG0295	cytidine deaminase activity
DFR85_RS07705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DFR85_RS07725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DFR85_RS07730	COG0281	malic enzyme
DFR85_RS07740	COG0085	RNA polymerase activity
DFR85_RS07745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DFR85_RS07750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DFR85_RS07755	COG1358	cellular component organization or biogenesis
DFR85_RS07775	COG0049	tRNA binding
DFR85_RS07785	COG0051	transcription antitermination factor activity, RNA binding
DFR85_RS07820	COG2813	Specifically methylates the guanine in position
DFR85_RS07825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DFR85_RS07830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DFR85_RS07840	COG1201	RNA secondary structure unwinding
DFR85_RS07845	COG0433	COG0433 Predicted ATPase
DFR85_RS07870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DFR85_RS07880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DFR85_RS07880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DFR85_RS07895	COG1797	cobyrinic acid a,c-diamide synthase activity
DFR85_RS07905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DFR85_RS07910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DFR85_RS07945	COG0557	exoribonuclease II activity
DFR85_RS07960	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DFR85_RS07965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS07970	COG1110	DNA topoisomerase II activity
DFR85_RS08015	COG0667	Aldo Keto reductase
DFR85_RS08020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DFR85_RS08030	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DFR85_RS08045	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
DFR85_RS08055	COG0163	prenyltransferase activity
DFR85_RS08085	COG0423	glycine-tRNA ligase activity
DFR85_RS08090	COG0010	Belongs to the arginase family
DFR85_RS08100	COG0023	Translation Initiation Factor
DFR85_RS08120	COG3276	selenocysteine insertion sequence binding
DFR85_RS08170	COG0489	protein tyrosine kinase activity
DFR85_RS08185	COG1280	lysine exporter protein (LysE YggA)
DFR85_RS08215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DFR85_RS08285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR85_RS08345	COG0315	cyclic pyranopterin monophosphate synthase activity
DFR85_RS08350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DFR85_RS08355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DFR85_RS08360	COG1881	PFAM PEBP family protein
DFR85_RS08365	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DFR85_RS08395	COG1703	isobutyryl-CoA mutase activity
DFR85_RS08400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR85_RS08420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DFR85_RS08425	COG0475	glutathione-regulated potassium exporter activity
DFR85_RS08455	COG1573	uracil-dna glycosylase
DFR85_RS08460	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS08475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DFR85_RS08490	COG0215	cysteine-tRNA ligase activity
DFR85_RS08495	COG2222	sugar isomerase
DFR85_RS08505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DFR85_RS08525	COG1607	acyl-coa hydrolase
DFR85_RS08540	COG1960	acyl-CoA dehydrogenase activity
DFR85_RS08545	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
DFR85_RS08580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFR85_RS08585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DFR85_RS08610	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DFR85_RS08615	COG1648	precorrin-2 dehydrogenase activity
DFR85_RS08615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DFR85_RS08640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DFR85_RS08655	COG1201	RNA secondary structure unwinding
DFR85_RS08665	COG0617	tRNA 3'-terminal CCA addition
DFR85_RS08665	COG3620	sequence-specific DNA binding
DFR85_RS08665	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DFR85_RS08690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DFR85_RS08695	COG1546	Belongs to the CinA family
DFR85_RS08695	COG1058	Belongs to the CinA family
DFR85_RS08700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DFR85_RS08715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DFR85_RS08720	COG0024	Methionine aminopeptidase
DFR85_RS08740	COG1078	dGTPase activity
DFR85_RS08745	COG0561	phosphatase activity
DFR85_RS08755	COG1358	cellular component organization or biogenesis
DFR85_RS08810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DFR85_RS08845	COG0417	DNA replication proofreading
DFR85_RS08865	COG0432	Pfam Uncharacterised protein family UPF0047
DFR85_RS08875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DFR85_RS08880	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DFR85_RS08885	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DFR85_RS08895	COG0200	Binds to the 23S rRNA
DFR85_RS08900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DFR85_RS08905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DFR85_RS08915	COG0052	Belongs to the universal ribosomal protein uS2 family
DFR85_RS08920	COG1355	regulation of microtubule-based process
DFR85_RS08935	COG1304	FMN binding
DFR85_RS08940	COG0142	geranyltranstransferase activity
DFR85_RS08945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DFR85_RS08970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS08985	COG0084	hydrolase, TatD family'
DFR85_RS09010	COG1216	Glycosyl transferase, family 2
DFR85_RS09010	COG0463	Glycosyl transferase, family 2
DFR85_RS09035	COG0402	S-adenosylhomocysteine deaminase activity
DFR85_RS09055	COG0303	'Molybdopterin
DFR85_RS09065	COG0516	GMP reductase activity
DFR85_RS09090	COG1321	iron dependent repressor
DFR85_RS09105	COG2379	hydroxypyruvate reductase
DFR85_RS09110	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR85_RS09115	COG0009	L-threonylcarbamoyladenylate synthase
DFR85_RS09120	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DFR85_RS09120	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DFR85_RS09125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR85_RS09130	COG0589	response to stress
DFR85_RS09145	COG0864	Transcriptional regulator
DFR85_RS09155	COG0460	homoserine dehydrogenase
DFR85_RS09160	COG0109	protoheme IX farnesyltransferase activity
DFR85_RS09170	COG1024	Enoyl-CoA hydratase
DFR85_RS09210	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR85_RS09220	COG0189	ligase activity
DFR85_RS09235	COG0165	Argininosuccinate lyase
DFR85_RS09240	COG0137	argininosuccinate synthase activity
DFR85_RS09255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DFR85_RS09260	COG0151	Belongs to the GarS family
DFR85_RS09270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DFR85_RS09275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DFR85_RS09280	COG0047	phosphoribosylformylglycinamidine synthase activity
DFR85_RS09300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DFR85_RS09305	COG0602	queuosine metabolic process
DFR85_RS09355	COG0540	Belongs to the ATCase OTCase family
DFR85_RS09360	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
DFR85_RS09370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DFR85_RS09375	COG0167	dihydroorotate dehydrogenase activity
DFR85_RS09390	COG2095	MarC family integral membrane protein
DFR85_RS09395	COG1522	sequence-specific DNA binding
DFR85_RS09410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR85_RS09415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DFR85_RS09425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DFR85_RS09435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DFR85_RS09440	COG0107	imidazoleglycerol-phosphate synthase activity
DFR85_RS09450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DFR85_RS09455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DFR85_RS09460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DFR85_RS09470	COG0495	leucyl-tRNA aminoacylation
DFR85_RS09480	COG0037	tRNA processing
DFR85_RS09495	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DFR85_RS09510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DFR85_RS09520	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DFR85_RS09525	COG0546	phosphoglycolate phosphatase activity
DFR85_RS09540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DFR85_RS09560	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DFR85_RS09570	COG0442	prolyl-tRNA aminoacylation
DFR85_RS09585	COG1394	ATPase activity, coupled to movement of substances
DFR85_RS09615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR85_RS09615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR85_RS09660	COG1260	myo-inositol-1-phosphate synthase
DFR85_RS09670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DFR85_RS09675	COG0713	ATP synthesis coupled electron transport
DFR85_RS09690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DFR85_RS09695	COG0649	NAD binding
DFR85_RS09700	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR85_RS09710	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DFR85_RS09730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DFR85_RS09790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DFR85_RS09795	COG0083	homoserine kinase activity
DFR85_RS09800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DFR85_RS09805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DFR85_RS09810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DFR85_RS09815	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DFR85_RS09825	COG3958	Transketolase
DFR85_RS09830	COG3959	Transketolase, thiamine diphosphate binding domain
DFR85_RS09835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DFR85_RS09865	COG1185	polyribonucleotide nucleotidyltransferase activity
DFR85_RS09890	COG0067	glutamate synthase
DFR85_RS09895	COG0069	glutamate synthase activity
DFR85_RS09955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DFR85_RS10025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DFR85_RS10030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR85_RS10040	COG0318	PFAM AMP-dependent synthetase and ligase
DFR85_RS10045	COG3118	belongs to the thioredoxin family
DFR85_RS10050	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DFR85_RS10055	COG0174	glutamine synthetase
DFR85_RS10065	COG0302	gtp cyclohydrolase
DFR85_RS10075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DFR85_RS10090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DFR85_RS10170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DFR85_RS10180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DFR85_RS10190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DFR85_RS10205	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DFR85_RS10210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DFR85_RS10235	COG0589	response to stress
DFR85_RS10245	COG0126	phosphoglycerate kinase activity
DFR85_RS10300	COG2814	Major facilitator Superfamily
DFR85_RS10380	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DFR85_RS10410	COG0396	ATPase activity
DFR85_RS10430	COG0509	glycine decarboxylation via glycine cleavage system
DFR85_RS10435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DFR85_RS10440	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DFR85_RS10445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DFR85_RS10465	COG0148	phosphopyruvate hydratase activity
DFR85_RS10485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS10490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DFR85_RS10505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DFR85_RS10510	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
DFR85_RS10540	COG0644	oxidoreductase
DFR85_RS10545	COG0525	valine-tRNA ligase activity
DFR85_RS10550	COG0436	Aminotransferase
DFR85_RS10555	COG0134	indole-3-glycerol-phosphate synthase activity
DFR85_RS10560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DFR85_RS10560	COG0512	Glutamine amidotransferase of anthranilate synthase
DFR85_RS10565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DFR85_RS10570	COG0135	phosphoribosylanthranilate isomerase activity
DFR85_RS10580	COG0159	tryptophan synthase activity
DFR85_RS10585	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DFR85_RS10590	COG1254	Belongs to the acylphosphatase family
DFR85_RS10595	COG1260	myo-inositol-1-phosphate synthase
DFR85_RS10605	COG0574	Belongs to the PEP-utilizing enzyme family
DFR85_RS10605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DFR85_RS10630	COG0527	aspartate kinase activity
DFR85_RS10650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DFR85_RS10685	COG0459	protein refolding
DFR85_RS10710	COG0018	arginyl-trna synthetase
DFR85_RS10735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFR85_RS10740	COG0252	asparaginase activity
DFR85_RS10770	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
DFR85_RS10820	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DFR85_RS10820	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DFR85_RS10835	COG0154	amidase activity
DFR85_RS10840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFR85_RS10845	COG1324	tolerance protein
DFR85_RS10880	COG1110	DNA topoisomerase II activity
DFR85_RS10910	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DFR85_RS10920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DFR85_RS10925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DFR85_RS10935	COG2084	Dehydrogenase
DFR85_RS10945	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS10955	COG0528	UMP kinase activity
DFR85_RS10965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFR85_RS11070	COG2271	Major facilitator Superfamily
DFR85_RS11085	COG0589	response to stress
DFR85_RS11095	COG3387	PFAM Glycoside hydrolase 15-related
DFR85_RS11100	COG0438	transferase activity, transferring glycosyl groups
DFR85_RS11135	COG0004	ammonium transporteR
DFR85_RS11155	COG1185	polyribonucleotide nucleotidyltransferase activity
DFR85_RS11190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DFR85_RS11200	COG1234	tRNA 3'-trailer cleavage
DFR85_RS11215	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DFR85_RS11250	COG0725	ABC transporter, periplasmic molybdate-binding protein
DFR85_RS11255	COG0300	oxidoreductase activity
DFR85_RS11275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DFR85_RS11275	COG1213	nucleotidyl transferase
DFR85_RS11280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DFR85_RS11285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DFR85_RS11300	COG0045	succinate-CoA ligase (ADP-forming) activity
DFR85_RS11315	COG0813	purine-nucleoside phosphorylase activity
DFR85_RS11320	COG1078	dGTPase activity
DFR85_RS11380	COG0123	including yeast histone deacetylase and acetoin utilization protein
DFR85_RS11415	COG2210	Belongs to the sulfur carrier protein TusA family
DFR85_RS11420	COG0425	Belongs to the sulfur carrier protein TusA family
DFR85_RS11435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR85_RS11450	COG2048	Heterodisulfide reductase, subunit B
DFR85_RS11455	COG2149	membrane
DFR85_RS11460	COG0530	calcium, potassium:sodium antiporter activity
DFR85_RS11475	COG0277	FAD linked oxidase domain protein
DFR85_RS11515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DFR85_RS11575	COG1335	isochorismatase
DFR85_RS11645	COG1063	alcohol dehydrogenase
DFR85_RS11665	COG0251	oxidation-reduction process
DFR85_RS11710	COG0149	triose-phosphate isomerase activity
DFR85_RS11725	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DFR85_RS11730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DFR85_RS11735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DFR85_RS11765	COG0531	amino acid
DFR85_RS11770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS11775	COG0114	fumarate hydratase activity
DFR85_RS11785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS11815	COG0509	glycine decarboxylation via glycine cleavage system
DFR85_RS11820	COG0095	Lipoate-protein ligase
DFR85_RS11845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DFR85_RS11860	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DFR85_RS11865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DFR85_RS11915	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DFR85_RS11930	COG1131	(ABC) transporter
DFR85_RS11955	COG0501	Belongs to the peptidase M48B family
DFR85_RS11995	COG1720	tRNA m6t6A37 methyltransferase activity
DFR85_RS12010	COG3511	phospholipase C
DFR85_RS12015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS12030	COG1139	Iron-sulfur cluster binding protein
DFR85_RS12045	COG1091	dTDP-4-dehydrorhamnose reductase activity
DFR85_RS12070	COG0667	Aldo Keto reductase
DFR85_RS12140	COG1518	maintenance of DNA repeat elements
DFR85_RS12175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DFR85_RS12245	COG2151	metal-sulfur cluster biosynthetic enzyme
DFR85_RS12260	COG0574	Belongs to the PEP-utilizing enzyme family
DFR85_RS12260	COG3848	Pyruvate phosphate dikinase
DFR85_RS12275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DFR85_RS12300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS12305	COG0535	radical SAM domain protein
DFR85_RS12310	COG0535	radical SAM domain protein
DFR85_RS12320	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DFR85_RS12320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DFR85_RS12330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DFR85_RS12490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR85_RS12500	COG0174	glutamine synthetase
DFR85_RS12510	COG1132	(ABC) transporter
DFR85_RS12520	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DFR85_RS12540	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS12545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DFR85_RS12545	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS12555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DFR85_RS12565	COG2814	Major facilitator Superfamily
DFR85_RS12605	COG4948	Mandelate Racemase Muconate Lactonizing
DFR85_RS12630	COG1802	Transcriptional regulator
DFR85_RS12640	COG2721	sulfolactate sulfo-lyase activity
DFR85_RS12645	COG2721	sulfolactate sulfo-lyase activity
DFR85_RS12650	COG2271	Major facilitator Superfamily
DFR85_RS12655	COG2814	Major facilitator Superfamily
DFR85_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS12665	COG1012	belongs to the aldehyde dehydrogenase family
DFR85_RS12670	COG4948	Mandelate Racemase Muconate Lactonizing
DFR85_RS12675	COG1312	Catalyzes the dehydration of D-mannonate
DFR85_RS12680	COG3386	PFAM SMP-30 Gluconolaconase
DFR85_RS12685	COG0395	ABC-type sugar transport system, permease component
DFR85_RS12690	COG1175	transmembrane transport
DFR85_RS12710	COG3842	ATPase activity
DFR85_RS12780	COG0509	glycine decarboxylation via glycine cleavage system
DFR85_RS12790	COG0095	Lipoate-protein ligase
DFR85_RS12795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DFR85_RS12800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DFR85_RS12835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DFR85_RS12840	COG0477	Major facilitator Superfamily
DFR85_RS12850	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DFR85_RS12915	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DFR85_RS12920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS12970	COG3383	formate dehydrogenase (NAD+) activity
DFR85_RS12985	COG0477	Major facilitator Superfamily
DFR85_RS13000	COG0517	IMP dehydrogenase activity
DFR85_RS13080	COG1078	dGTPase activity
DFR85_RS13125	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DFR85_RS13135	COG1518	maintenance of DNA repeat elements
DFR85_RS13210	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DFR85_RS13300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DFR85_RS13320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DFR85_RS13340	COG1201	RNA secondary structure unwinding
DFR85_RS13355	COG0515	serine threonine protein kinase
DFR85_RS13410	COG1489	DNA binding
DFR85_RS13415	COG1401	restriction endodeoxyribonuclease activity
DFR85_RS13450	COG2814	Major facilitator Superfamily
DFR85_RS13500	COG1337	RAMP superfamily
DFR85_RS13535	COG1051	belongs to the nudix hydrolase family
DFR85_RS13535	COG1056	cytidyltransferase-related domain
DFR85_RS13545	COG0450	alkyl hydroperoxide reductase
DFR85_RS13550	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DFR85_RS13670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DFR85_RS13685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS13825	COG1960	acyl-CoA dehydrogenase activity
DFR85_RS13835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DFR85_RS13865	COG0437	4 iron, 4 sulfur cluster binding
DFR85_RS13870	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DFR85_RS13875	COG1144	Oxidoreductase
DFR85_RS13880	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS13885	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS13905	COG1131	(ABC) transporter
DFR85_RS13935	COG1131	(ABC) transporter
DFR85_RS13965	COG3383	formate dehydrogenase (NAD+) activity
DFR85_RS13975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DFR85_RS14060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DFR85_RS14065	COG1960	acyl-CoA dehydrogenase activity
DFR85_RS14115	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DFR85_RS14125	COG1733	regulation of RNA biosynthetic process
DFR85_RS14145	COG0409	Hydrogenase expression formation protein
DFR85_RS14150	COG0298	carbon dioxide binding
DFR85_RS14180	COG0531	amino acid
DFR85_RS14250	COG0469	pyruvate kinase activity
DFR85_RS14260	COG0179	Fumarylacetoacetate (FAA) hydrolase
DFR85_RS14265	COG0598	Magnesium transport protein CorA
DFR85_RS14300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DFR85_RS14305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR85_RS14310	COG0477	Major facilitator Superfamily
DFR85_RS14315	COG1846	Transcriptional regulator
DFR85_RS14335	COG2151	metal-sulfur cluster biosynthetic enzyme
DFR85_RS14360	COG3350	monooxygenase activity
DFR85_RS14400	COG1012	belongs to the aldehyde dehydrogenase family
DFR85_RS14405	COG0028	Belongs to the TPP enzyme family
DFR85_RS14450	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS14455	COG0667	Aldo Keto reductase
DFR85_RS14465	COG0412	Dienelactone hydrolase
DFR85_RS14470	COG0500	methyltransferase
DFR85_RS14475	COG2814	Major facilitator Superfamily
DFR85_RS14485	COG1131	(ABC) transporter
DFR85_RS14520	COG2084	Dehydrogenase
DFR85_RS14550	COG0477	Major facilitator Superfamily
DFR85_RS14555	COG1846	Transcriptional regulator
DFR85_RS14580	COG1012	belongs to the aldehyde dehydrogenase family
DFR85_RS14595	COG4948	Mandelate Racemase Muconate Lactonizing
DFR85_RS14610	COG1024	Enoyl-CoA hydratase
DFR85_RS14615	COG1960	acyl-CoA dehydrogenase activity
DFR85_RS14620	COG0318	PFAM AMP-dependent synthetase and ligase
DFR85_RS14660	COG2086	electron transfer activity
DFR85_RS14670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS14740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DFR85_RS14745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DFR85_RS14750	COG1012	belongs to the aldehyde dehydrogenase family
DFR85_RS14760	COG0318	PFAM AMP-dependent synthetase and ligase
DFR85_RS14780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS14790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DFR85_RS14795	COG2124	cytochrome p450
DFR85_RS14805	COG0022	dehydrogenase e1 component
DFR85_RS14810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DFR85_RS14815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS14840	COG1051	belongs to the nudix hydrolase family
DFR85_RS14840	COG1056	cytidyltransferase-related domain
DFR85_RS14850	COG1832	CoA-binding protein
DFR85_RS14875	COG0277	FAD linked oxidase domain protein
DFR85_RS14910	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DFR85_RS14940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS14970	COG1024	Enoyl-CoA hydratase
DFR85_RS14975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS14990	COG4948	Mandelate Racemase Muconate Lactonizing
DFR85_RS14995	COG0318	PFAM AMP-dependent synthetase and ligase
DFR85_RS15000	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS15005	COG2271	Major facilitator Superfamily
DFR85_RS15015	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS15025	COG1131	(ABC) transporter
DFR85_RS15050	COG1233	COG1233 Phytoene dehydrogenase and related
DFR85_RS15060	COG0393	Putative heavy-metal-binding
DFR85_RS15085	COG0477	Major facilitator Superfamily
DFR85_RS15095	COG2814	Major facilitator Superfamily
DFR85_RS15100	COG2226	methyltransferase
DFR85_RS15170	COG0477	Major facilitator Superfamily
DFR85_RS15175	COG4948	Mandelate Racemase Muconate Lactonizing
DFR85_RS15200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DFR85_RS15210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DFR85_RS15220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DFR85_RS15270	COG4274	PFAM GYD family protein
DFR85_RS15300	COG0426	domain, Protein
DFR85_RS15310	COG0281	malic enzyme
DFR85_RS15335	COG0183	Belongs to the thiolase family
DFR85_RS15350	COG0318	PFAM AMP-dependent synthetase and ligase
DFR85_RS15380	COG1024	Enoyl-CoA hydratase
DFR85_RS15385	COG1024	Enoyl-CoA hydratase
DFR85_RS15405	COG0589	response to stress
DFR85_RS15415	COG0179	Fumarylacetoacetate (FAA) hydrolase
DFR85_RS15425	COG2368	4-hydroxyphenylacetate
DFR85_RS15460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DFR85_RS15465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS15480	COG3842	ATPase activity
DFR85_RS15495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS15520	COG2271	Major facilitator Superfamily
DFR85_RS15525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR85_RS15545	COG0425	Belongs to the sulfur carrier protein TusA family
DFR85_RS15555	COG0425	Belongs to the sulfur carrier protein TusA family
DFR85_RS15625	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DFR85_RS15625	COG0517	IMP dehydrogenase activity
DFR85_RS15640	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DFR85_RS15645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS15670	COG0657	acetylesterase activity
DFR85_RS15690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR85_RS15700	COG0604	alcohol dehydrogenase
DFR85_RS15710	COG0450	alkyl hydroperoxide reductase
DFR85_RS15720	COG1960	acyl-CoA dehydrogenase activity
DFR85_RS15765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS15820	COG0372	Belongs to the citrate synthase family
DFR85_RS15825	COG0516	GMP reductase activity
DFR85_RS15825	COG0517	IMP dehydrogenase activity
DFR85_RS15830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DFR85_RS15835	COG2079	MmgE PrpD family protein