locus-tag	class	description
DFR85_RS01990	COG0028	Belongs to the TPP enzyme family
DFR85_RS02215	COG1592	Rubrerythrin
DFR85_RS04025	COG0489	protein tyrosine kinase activity
DFR85_RS05095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DFR85_RS05920	COG2814	Major facilitator Superfamily
DFR85_RS06485	COG3547	Transposase (IS116 IS110 IS902 family)
DFR85_RS08260	COG2814	Major facilitator Superfamily
DFR85_RS11240	COG0243	molybdopterin cofactor binding
DFR85_RS12185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS13220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS13760	COG0730	response to heat
DFR85_RS13770	COG0813	purine-nucleoside phosphorylase activity
DFR85_RS14285	COG4555	ABC transporter
DFR85_RS14535	COG2814	Major facilitator Superfamily
DFR85_RS14560	COG1846	Transcriptional regulator
DFR85_RS16170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DFR85_RS16235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DFR85_RS16250	COG1131	(ABC) transporter
DFR85_RS16285	COG0823	Involved in the tonB-independent uptake of proteins
DFR85_RS16285	COG1506	peptidase
DFR85_RS16285	COG4946	Tricorn protease homolog
DFR85_RS16330	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
DFR85_RS16365	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DFR85_RS16370	COG0778	Nitroreductase
DFR85_RS16375	COG3830	Belongs to the UPF0237 family
DFR85_RS16380	COG2848	UPF0210 protein
DFR85_RS16435	COG0183	Belongs to the thiolase family
DFR85_RS16440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR85_RS16460	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DFR85_RS16485	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DFR85_RS16495	COG0351	phosphomethylpyrimidine kinase
DFR85_RS16525	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DFR85_RS16535	COG1131	(ABC) transporter
DFR85_RS16585	COG0720	synthase
DFR85_RS16600	COG0492	ferredoxin-NADP+ reductase activity
DFR85_RS16610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS16630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR85_RS16630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR85_RS16635	COG0346	lactoylglutathione lyase activity
DFR85_RS16640	COG0071	Belongs to the small heat shock protein (HSP20) family
DFR85_RS16685	COG1648	precorrin-2 dehydrogenase activity
DFR85_RS16685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DFR85_RS16725	COG1063	alcohol dehydrogenase
DFR85_RS16730	COG0430	RNA-3'-phosphate cyclase activity
DFR85_RS16745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DFR85_RS16750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS16760	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DFR85_RS16775	COG0535	radical SAM domain protein
DFR85_RS16860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DFR85_RS16880	COG0805	protein transport
DFR85_RS16910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DFR85_RS16930	COG0297	glycogen (starch) synthase activity
DFR85_RS16940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DFR85_RS16965	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR85_RS16970	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DFR85_RS17015	COG1063	alcohol dehydrogenase
DFR85_RS17030	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
DFR85_RS17035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR85_RS17040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DFR85_RS17040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DFR85_RS17100	COG0735	belongs to the Fur family
DFR85_RS17120	COG0517	IMP dehydrogenase activity
DFR85_RS17120	COG0516	GMP reductase activity
DFR85_RS17145	COG3118	belongs to the thioredoxin family
DFR85_RS17155	COG1252	NADH dehydrogenase
DFR85_RS17215	COG0492	ferredoxin-NADP+ reductase activity
DFR85_RS17230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DFR85_RS17245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DFR85_RS17250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DFR85_RS17260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DFR85_RS17280	COG0561	phosphatase activity
DFR85_RS17295	COG0537	adenosine 5'-monophosphoramidase activity
DFR85_RS17300	COG1335	isochorismatase
DFR85_RS17315	COG0494	nUDIX hydrolase
DFR85_RS17330	COG1573	uracil-dna glycosylase
DFR85_RS17340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DFR85_RS17345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DFR85_RS17345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DFR85_RS17395	COG0538	isocitrate dehydrogenase activity
DFR85_RS17410	COG2154	pterin-4-alpha-carbinolamine dehydratase
DFR85_RS17415	COG2105	PFAM AIG2 family protein
DFR85_RS17435	COG0330	HflC and HflK could
DFR85_RS17490	COG0525	valine-tRNA ligase activity
DFR85_RS17525	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DFR85_RS17530	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS17535	COG1331	Highly conserved protein containing a thioredoxin domain
DFR85_RS17575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DFR85_RS17575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR85_RS17580	COG0438	transferase activity, transferring glycosyl groups
DFR85_RS17605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS17625	COG1131	(ABC) transporter
DFR85_RS17670	COG1192	Involved in chromosome partitioning
DFR85_RS17705	COG0123	including yeast histone deacetylase and acetoin utilization protein
DFR85_RS17710	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DFR85_RS17755	COG1201	RNA secondary structure unwinding
DFR85_RS17765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DFR85_RS17775	COG0243	molybdopterin cofactor binding
DFR85_RS17810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DFR85_RS17810	COG2226	methyltransferase
DFR85_RS17810	COG0596	Alpha beta hydrolase
DFR85_RS17820	COG2271	Major facilitator Superfamily
DFR85_RS17835	COG0301	tRNA thio-modification
DFR85_RS17840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DFR85_RS17850	COG0651	ATP synthesis coupled electron transport
DFR85_RS17855	COG0649	NAD binding
DFR85_RS17860	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR85_RS17865	COG0651	ATP synthesis coupled electron transport
DFR85_RS17870	COG0650	Formate hydrogenlyase subunit 4
DFR85_RS17920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR85_RS17935	COG0477	Major facilitator Superfamily
DFR85_RS17955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS17960	COG1012	belongs to the aldehyde dehydrogenase family
DFR85_RS17965	COG0243	molybdopterin cofactor binding
DFR85_RS17975	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS17980	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS17980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DFR85_RS18005	COG0463	Glycosyl transferase, family 2
DFR85_RS18010	COG3386	PFAM SMP-30 Gluconolaconase
DFR85_RS18050	COG2226	methyltransferase
DFR85_RS18085	COG0601	transmembrane transport
DFR85_RS18090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR85_RS18095	COG0444	Belongs to the ABC transporter superfamily
DFR85_RS18135	COG2308	Evidence 4 Homologs of previously reported genes of
DFR85_RS18155	COG1473	amidohydrolase
DFR85_RS18170	COG0531	amino acid
DFR85_RS18230	COG0531	amino acid
DFR85_RS18235	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS18240	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS18255	COG0588	phosphoglycerate mutase activity
DFR85_RS18265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR85_RS18270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR85_RS18315	COG0804	urea catabolic process
DFR85_RS18320	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DFR85_RS18325	COG0830	nickel cation binding
DFR85_RS18330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DFR85_RS18340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR85_RS18370	COG1131	(ABC) transporter
DFR85_RS18375	COG4946	Tricorn protease homolog
DFR85_RS18375	COG0823	Involved in the tonB-independent uptake of proteins
DFR85_RS18375	COG1506	peptidase
DFR85_RS18380	COG4152	abc transporter atp-binding protein
DFR85_RS18440	COG0601	transmembrane transport
DFR85_RS18445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR85_RS18450	COG0444	Belongs to the ABC transporter superfamily
DFR85_RS18455	COG4608	Belongs to the ABC transporter superfamily
DFR85_RS18510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DFR85_RS18515	COG0531	amino acid
DFR85_RS18540	COG2002	toxin-antitoxin pair type II binding
DFR85_RS18550	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DFR85_RS18590	COG0402	S-adenosylhomocysteine deaminase activity
DFR85_RS18605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DFR85_RS18625	COG4638	Rieske (2fe-2S)
DFR85_RS18635	COG0477	Major facilitator Superfamily
DFR85_RS18640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DFR85_RS18645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DFR85_RS18660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DFR85_RS18660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DFR85_RS18665	COG0167	dihydroorotate dehydrogenase activity
DFR85_RS18675	COG1953	Uracil, thiamine, allantoin
DFR85_RS18705	COG1953	Uracil, thiamine, allantoin
DFR85_RS18720	COG0243	molybdopterin cofactor binding
DFR85_RS18790	COG1228	amidohydrolase
DFR85_RS18795	COG2814	Major facilitator Superfamily
DFR85_RS18830	COG0531	amino acid
DFR85_RS18835	COG0519	Catalyzes the synthesis of GMP from XMP
DFR85_RS18845	COG2723	6-phospho-beta-galactosidase activity
DFR85_RS18850	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DFR85_RS18875	COG0731	radical SAM domain protein
DFR85_RS18925	COG1741	Belongs to the pirin family
DFR85_RS18945	COG0308	aminopeptidase N
DFR85_RS18960	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR85_RS18975	COG0501	Belongs to the peptidase M48B family
DFR85_RS18985	COG3842	ATPase activity
DFR85_RS18990	COG1175	transmembrane transport
DFR85_RS19025	COG3547	Transposase (IS116 IS110 IS902 family)
DFR85_RS19170	COG0644	oxidoreductase
DFR85_RS19265	COG0243	molybdopterin cofactor binding
DFR85_RS19310	COG0535	radical SAM domain protein
DFR85_RS19320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DFR85_RS19325	COG1120	ATPase activity
DFR85_RS19380	COG2226	methyltransferase
DFR85_RS19390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DFR85_RS19450	COG0516	GMP reductase activity
DFR85_RS19515	COG0719	Fe-S assembly protein
DFR85_RS19555	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DFR85_RS19610	COG1575	Belongs to the MenA family. Type 1 subfamily
DFR85_RS19650	COG0409	Hydrogenase expression formation protein
DFR85_RS19660	COG0309	Hydrogenase expression formation protein (HypE)
DFR85_RS19750	COG1131	(ABC) transporter
DFR85_RS19780	COG0375	protein maturation
DFR85_RS19835	COG1373	ATPase (AAA superfamily
DFR85_RS19840	COG0459	protein refolding
DFR85_RS19850	COG0673	inositol 2-dehydrogenase activity
DFR85_RS19860	COG0675	Transposase, IS605 OrfB family
DFR85_RS19910	COG0667	Aldo Keto reductase
DFR85_RS19945	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DFR85_RS19960	COG2723	6-phospho-beta-galactosidase activity
DFR85_RS19990	COG0601	transmembrane transport
DFR85_RS19995	COG0444	Belongs to the ABC transporter superfamily
DFR85_RS20000	COG4608	Belongs to the ABC transporter superfamily
DFR85_RS20015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR85_RS20050	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DFR85_RS20055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DFR85_RS20115	COG1215	transferase activity, transferring glycosyl groups
DFR85_RS20125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DFR85_RS20130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DFR85_RS20135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DFR85_RS20140	COG1215	transferase activity, transferring glycosyl groups
DFR85_RS20150	COG0438	transferase activity, transferring glycosyl groups
DFR85_RS20245	COG1215	transferase activity, transferring glycosyl groups
DFR85_RS20260	COG0297	glycogen (starch) synthase activity
DFR85_RS20320	COG0531	amino acid
DFR85_RS20375	COG0515	serine threonine protein kinase
DFR85_RS20375	COG2815	serine threonine protein kinase
DFR85_RS20450	COG2815	serine threonine protein kinase
DFR85_RS20450	COG0515	serine threonine protein kinase
DFR85_RS20665	COG1373	ATPase (AAA superfamily
DFR85_RS20820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DFR85_RS20825	COG1216	Glycosyl transferase, family 2
DFR85_RS20825	COG1442	glycosyl transferase family 8
DFR85_RS20860	COG1216	Glycosyl transferase, family 2
DFR85_RS21010	COG0438	transferase activity, transferring glycosyl groups
DFR85_RS21025	COG0438	transferase activity, transferring glycosyl groups
DFR85_RS21045	COG2217	Heavy metal translocating P-type atpase
DFR85_RS21095	COG2271	Major facilitator Superfamily
DFR85_RS21100	COG1968	undecaprenyl-diphosphatase activity
DFR85_RS21145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DFR85_RS21145	COG0045	succinate-CoA ligase (ADP-forming) activity
DFR85_RS21145	COG1042	CoA-binding domain protein
DFR85_RS21150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DFR85_RS21155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR85_RS21180	COG0037	tRNA processing
DFR85_RS21200	COG0513	Belongs to the DEAD box helicase family
DFR85_RS21235	COG0475	glutathione-regulated potassium exporter activity
DFR85_RS21265	COG4946	Tricorn protease homolog
DFR85_RS21265	COG0793	Belongs to the peptidase S41A family
DFR85_RS21295	COG0095	Lipoate-protein ligase
DFR85_RS21300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR85_RS21345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DFR85_RS21375	COG0477	Major facilitator Superfamily
DFR85_RS21395	COG3264	Mechanosensitive ion channel
DFR85_RS21395	COG1196	nuclear chromosome segregation
DFR85_RS21415	COG0671	phosphoesterase, PA-phosphatase related
DFR85_RS21445	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DFR85_RS21455	COG0157	Belongs to the NadC ModD family
DFR85_RS21500	COG0708	Exodeoxyribonuclease III
DFR85_RS21520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DFR85_RS21530	COG3387	PFAM Glycoside hydrolase 15-related
DFR85_RS21585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS21590	COG2271	Major facilitator Superfamily
DFR85_RS21610	COG1121	(ABC) transporter
DFR85_RS21615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DFR85_RS21645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DFR85_RS21650	COG0066	3-isopropylmalate dehydratase activity
DFR85_RS21655	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
DFR85_RS21665	COG1515	deoxyribonuclease V activity
DFR85_RS21680	COG0450	alkyl hydroperoxide reductase
DFR85_RS21695	COG0372	Belongs to the citrate synthase family
DFR85_RS21720	COG4581	dead DEAH box helicase
DFR85_RS21730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DFR85_RS21740	COG0439	Biotin carboxylase
DFR85_RS21750	COG1116	anion transmembrane transporter activity
DFR85_RS21760	COG0513	Belongs to the DEAD box helicase family
DFR85_RS21775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DFR85_RS21785	COG0601	transmembrane transport
DFR85_RS21790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DFR85_RS21815	COG0756	dUTP diphosphatase activity
DFR85_RS21850	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DFR85_RS21855	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DFR85_RS21875	COG1522	sequence-specific DNA binding
DFR85_RS21880	COG0644	oxidoreductase
DFR85_RS21890	COG1446	asparaginase
DFR85_RS21905	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DFR85_RS21925	COG1053	succinate dehydrogenase
DFR85_RS21945	COG2304	oxidoreductase activity
DFR85_RS21950	COG0714	Associated with various cellular activities
DFR85_RS21965	COG0303	'Molybdopterin
DFR85_RS21975	COG0626	cystathionine gamma-synthase activity
DFR85_RS22040	COG0446	pyridine nucleotide-disulphide oxidoreductase
DFR85_RS22075	COG1584	GPR1 FUN34 yaaH family protein
DFR85_RS22080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS22110	COG1444	tRNA N-acetyltransferase activity
DFR85_RS22120	COG2814	Major facilitator Superfamily
DFR85_RS22125	COG0589	response to stress
DFR85_RS22130	COG1131	(ABC) transporter
DFR85_RS22165	COG1444	tRNA N-acetyltransferase activity
DFR85_RS22175	COG0405	Gamma-glutamyltransferase
DFR85_RS22190	COG1215	transferase activity, transferring glycosyl groups
DFR85_RS22200	COG0351	phosphomethylpyrimidine kinase
DFR85_RS22205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DFR85_RS22210	COG1234	tRNA 3'-trailer cleavage
DFR85_RS22250	COG0463	Glycosyl transferase, family 2
DFR85_RS22270	COG1063	alcohol dehydrogenase
DFR85_RS22275	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DFR85_RS22290	COG0519	Catalyzes the synthesis of GMP from XMP
DFR85_RS22290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DFR85_RS22295	COG0501	Belongs to the peptidase M48B family
DFR85_RS22300	COG0516	GMP reductase activity
DFR85_RS22300	COG0517	IMP dehydrogenase activity
DFR85_RS22325	COG1830	Aldolase
DFR85_RS22345	COG2860	membrane
DFR85_RS22380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DFR85_RS22400	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DFR85_RS22405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR85_RS22410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DFR85_RS22415	COG0189	ligase activity
DFR85_RS22430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DFR85_RS22435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DFR85_RS22460	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DFR85_RS22500	COG0028	Belongs to the TPP enzyme family
DFR85_RS22525	COG0017	Asparaginyl-tRNA synthetase
DFR85_RS22530	COG0585	pseudouridine synthase activity
DFR85_RS22550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS22560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DFR85_RS22560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DFR85_RS22565	COG1648	precorrin-2 dehydrogenase activity
DFR85_RS22565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DFR85_RS22570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DFR85_RS22575	COG0113	porphobilinogen synthase activity
DFR85_RS22580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR85_RS22585	COG0181	hydroxymethylbilane synthase activity
DFR85_RS22610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DFR85_RS22620	COG1793	dna ligase
DFR85_RS22625	COG0717	Belongs to the dCTP deaminase family
DFR85_RS22670	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
DFR85_RS22685	COG0504	CTP synthase activity
DFR85_RS22710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DFR85_RS22720	COG0492	ferredoxin-NADP+ reductase activity
DFR85_RS22735	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS22770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DFR85_RS22775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DFR85_RS22830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DFR85_RS22850	COG0200	Binds to the 23S rRNA
DFR85_RS22860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DFR85_RS22885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DFR85_RS22895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DFR85_RS22910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DFR85_RS22925	COG0255	Belongs to the universal ribosomal protein uL29 family
DFR85_RS22930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DFR85_RS22935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DFR85_RS22940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DFR85_RS22945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DFR85_RS22950	COG0089	rRNA binding
DFR85_RS22955	COG0088	Forms part of the polypeptide exit tunnel
DFR85_RS22960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DFR85_RS22975	COG0473	3-isopropylmalate dehydrogenase activity
DFR85_RS22990	COG0546	phosphoglycolate phosphatase activity
DFR85_RS22995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DFR85_RS23000	COG0322	excinuclease ABC activity
DFR85_RS23030	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DFR85_RS23035	COG1185	polyribonucleotide nucleotidyltransferase activity
DFR85_RS23070	COG0012	GTP binding
DFR85_RS23075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DFR85_RS23085	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DFR85_RS23090	COG2264	protein methyltransferase activity
DFR85_RS23095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DFR85_RS23135	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DFR85_RS23160	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DFR85_RS23165	COG0371	Dehydrogenase
DFR85_RS23170	COG1047	Peptidyl-prolyl cis-trans
DFR85_RS23180	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DFR85_RS23185	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DFR85_RS23215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DFR85_RS23225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS23240	COG0343	queuine tRNA-ribosyltransferase activity
DFR85_RS23260	COG0124	histidyl-tRNA synthetase
DFR85_RS23300	COG1980	fructose-bisphosphate aldolase activity
DFR85_RS23305	COG1121	(ABC) transporter
DFR85_RS23390	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DFR85_RS23445	COG1056	cytidyltransferase-related domain
DFR85_RS23445	COG1051	belongs to the nudix hydrolase family
DFR85_RS23460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR85_RS23460	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DFR85_RS23485	COG1605	Chorismate mutase
DFR85_RS23485	COG0077	Prephenate dehydratase
DFR85_RS23495	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DFR85_RS23515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DFR85_RS23530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DFR85_RS23535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DFR85_RS23545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DFR85_RS23550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFR85_RS23555	COG0295	cytidine deaminase activity
DFR85_RS23560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DFR85_RS23580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DFR85_RS23585	COG0281	malic enzyme
DFR85_RS23595	COG0085	RNA polymerase activity
DFR85_RS23600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DFR85_RS23605	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DFR85_RS23610	COG1358	cellular component organization or biogenesis
DFR85_RS23630	COG0049	tRNA binding
DFR85_RS23640	COG0051	transcription antitermination factor activity, RNA binding
DFR85_RS23675	COG2813	Specifically methylates the guanine in position
DFR85_RS23680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DFR85_RS23685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DFR85_RS23695	COG1201	RNA secondary structure unwinding
DFR85_RS23700	COG0433	COG0433 Predicted ATPase
DFR85_RS23725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DFR85_RS23735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DFR85_RS23735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DFR85_RS23750	COG1797	cobyrinic acid a,c-diamide synthase activity
DFR85_RS23760	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DFR85_RS23765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DFR85_RS23800	COG0557	exoribonuclease II activity
DFR85_RS23815	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DFR85_RS23820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS23825	COG1110	DNA topoisomerase II activity
DFR85_RS23870	COG0667	Aldo Keto reductase
DFR85_RS23875	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DFR85_RS23885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DFR85_RS23900	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
DFR85_RS23910	COG0163	prenyltransferase activity
DFR85_RS23940	COG0423	glycine-tRNA ligase activity
DFR85_RS23945	COG0010	Belongs to the arginase family
DFR85_RS23955	COG0023	Translation Initiation Factor
DFR85_RS23975	COG3276	selenocysteine insertion sequence binding
DFR85_RS24035	COG0489	protein tyrosine kinase activity
DFR85_RS24050	COG1280	lysine exporter protein (LysE YggA)
DFR85_RS24080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DFR85_RS24145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR85_RS24205	COG0315	cyclic pyranopterin monophosphate synthase activity
DFR85_RS24210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DFR85_RS24215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DFR85_RS24220	COG1881	PFAM PEBP family protein
DFR85_RS24225	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DFR85_RS24255	COG1703	isobutyryl-CoA mutase activity
DFR85_RS24260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR85_RS24280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DFR85_RS24285	COG0475	glutathione-regulated potassium exporter activity
DFR85_RS24315	COG1573	uracil-dna glycosylase
DFR85_RS24320	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS24335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DFR85_RS24350	COG0215	cysteine-tRNA ligase activity
DFR85_RS24355	COG2222	sugar isomerase
DFR85_RS24365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DFR85_RS24385	COG1607	acyl-coa hydrolase
DFR85_RS24400	COG1960	acyl-CoA dehydrogenase activity
DFR85_RS24405	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
DFR85_RS24440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFR85_RS24445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DFR85_RS24470	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DFR85_RS24475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DFR85_RS24475	COG1648	precorrin-2 dehydrogenase activity
DFR85_RS24500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DFR85_RS24515	COG1201	RNA secondary structure unwinding
DFR85_RS24520	COG0617	tRNA 3'-terminal CCA addition
DFR85_RS24520	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DFR85_RS24520	COG3620	sequence-specific DNA binding
DFR85_RS24545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DFR85_RS24550	COG1058	Belongs to the CinA family
DFR85_RS24550	COG1546	Belongs to the CinA family
DFR85_RS24555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DFR85_RS24570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DFR85_RS24575	COG0024	Methionine aminopeptidase
DFR85_RS24595	COG1078	dGTPase activity
DFR85_RS24600	COG0561	phosphatase activity
DFR85_RS24610	COG1358	cellular component organization or biogenesis
DFR85_RS24660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DFR85_RS24695	COG0417	DNA replication proofreading
DFR85_RS24715	COG0432	Pfam Uncharacterised protein family UPF0047
DFR85_RS24725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DFR85_RS24730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DFR85_RS24735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DFR85_RS24745	COG0200	Binds to the 23S rRNA
DFR85_RS24750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DFR85_RS24755	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DFR85_RS24765	COG0052	Belongs to the universal ribosomal protein uS2 family
DFR85_RS24770	COG1355	regulation of microtubule-based process
DFR85_RS24785	COG1304	FMN binding
DFR85_RS24790	COG0142	geranyltranstransferase activity
DFR85_RS24795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DFR85_RS24820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS24835	COG0084	hydrolase, TatD family'
DFR85_RS24860	COG1216	Glycosyl transferase, family 2
DFR85_RS24860	COG0463	Glycosyl transferase, family 2
DFR85_RS24880	COG0402	S-adenosylhomocysteine deaminase activity
DFR85_RS24900	COG0303	'Molybdopterin
DFR85_RS24910	COG0516	GMP reductase activity
DFR85_RS24935	COG1321	iron dependent repressor
DFR85_RS24950	COG2379	hydroxypyruvate reductase
DFR85_RS24955	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR85_RS24960	COG0009	L-threonylcarbamoyladenylate synthase
DFR85_RS24965	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DFR85_RS24965	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DFR85_RS24970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR85_RS24975	COG0589	response to stress
DFR85_RS24990	COG0864	Transcriptional regulator
DFR85_RS25000	COG0460	homoserine dehydrogenase
DFR85_RS25005	COG0109	protoheme IX farnesyltransferase activity
DFR85_RS25015	COG1024	Enoyl-CoA hydratase
DFR85_RS25055	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR85_RS25065	COG0189	ligase activity
DFR85_RS25080	COG0165	Argininosuccinate lyase
DFR85_RS25085	COG0137	argininosuccinate synthase activity
DFR85_RS25100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DFR85_RS25105	COG0151	Belongs to the GarS family
DFR85_RS25115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DFR85_RS25120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DFR85_RS25125	COG0047	phosphoribosylformylglycinamidine synthase activity
DFR85_RS25145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DFR85_RS25150	COG0602	queuosine metabolic process
DFR85_RS25200	COG0540	Belongs to the ATCase OTCase family
DFR85_RS25205	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
DFR85_RS25215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DFR85_RS25220	COG0167	dihydroorotate dehydrogenase activity
DFR85_RS25235	COG2095	MarC family integral membrane protein
DFR85_RS25240	COG1522	sequence-specific DNA binding
DFR85_RS25255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR85_RS25260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DFR85_RS25270	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DFR85_RS25280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DFR85_RS25285	COG0107	imidazoleglycerol-phosphate synthase activity
DFR85_RS25295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DFR85_RS25300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DFR85_RS25305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DFR85_RS25315	COG0495	leucyl-tRNA aminoacylation
DFR85_RS25325	COG0037	tRNA processing
DFR85_RS25345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DFR85_RS25360	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DFR85_RS25370	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DFR85_RS25375	COG0546	phosphoglycolate phosphatase activity
DFR85_RS25390	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DFR85_RS25410	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DFR85_RS25420	COG0442	prolyl-tRNA aminoacylation
DFR85_RS25435	COG1394	ATPase activity, coupled to movement of substances
DFR85_RS25465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR85_RS25465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR85_RS25495	COG0417	DNA replication proofreading
DFR85_RS25510	COG1260	myo-inositol-1-phosphate synthase
DFR85_RS25515	COG1007	ATP synthesis coupled electron transport
DFR85_RS25520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DFR85_RS25525	COG0713	ATP synthesis coupled electron transport
DFR85_RS25535	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR85_RS25540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DFR85_RS25545	COG0649	NAD binding
DFR85_RS25550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR85_RS25560	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DFR85_RS25580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DFR85_RS25630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DFR85_RS25640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DFR85_RS25645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DFR85_RS25650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DFR85_RS25655	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DFR85_RS25665	COG3958	Transketolase
DFR85_RS25670	COG3959	Transketolase, thiamine diphosphate binding domain
DFR85_RS25675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DFR85_RS25705	COG1185	polyribonucleotide nucleotidyltransferase activity
DFR85_RS25730	COG0067	glutamate synthase
DFR85_RS25735	COG0069	glutamate synthase activity
DFR85_RS25780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DFR85_RS25790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DFR85_RS25865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DFR85_RS25870	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR85_RS25880	COG0318	PFAM AMP-dependent synthetase and ligase
DFR85_RS25885	COG3118	belongs to the thioredoxin family
DFR85_RS25890	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DFR85_RS25895	COG0174	glutamine synthetase
DFR85_RS25905	COG0302	gtp cyclohydrolase
DFR85_RS25915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DFR85_RS25930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DFR85_RS26010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DFR85_RS26020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DFR85_RS26030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DFR85_RS26045	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DFR85_RS26050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DFR85_RS26075	COG0589	response to stress
DFR85_RS26085	COG0126	phosphoglycerate kinase activity
DFR85_RS26150	COG2814	Major facilitator Superfamily
DFR85_RS26230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DFR85_RS26260	COG0396	ATPase activity
DFR85_RS26280	COG0509	glycine decarboxylation via glycine cleavage system
DFR85_RS26285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DFR85_RS26290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DFR85_RS26295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DFR85_RS26310	COG0148	phosphopyruvate hydratase activity
DFR85_RS26330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR85_RS26335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DFR85_RS26350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DFR85_RS26355	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
DFR85_RS26385	COG0644	oxidoreductase
DFR85_RS26390	COG0525	valine-tRNA ligase activity
DFR85_RS26395	COG0436	Aminotransferase
DFR85_RS26400	COG0134	indole-3-glycerol-phosphate synthase activity
DFR85_RS26405	COG0512	Glutamine amidotransferase of anthranilate synthase
DFR85_RS26405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DFR85_RS26410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DFR85_RS26415	COG0135	phosphoribosylanthranilate isomerase activity
DFR85_RS26425	COG0159	tryptophan synthase activity
DFR85_RS26430	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DFR85_RS26435	COG1254	Belongs to the acylphosphatase family
DFR85_RS26440	COG1260	myo-inositol-1-phosphate synthase
DFR85_RS26450	COG0574	Belongs to the PEP-utilizing enzyme family
DFR85_RS26450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DFR85_RS26475	COG0527	aspartate kinase activity
DFR85_RS26495	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DFR85_RS26530	COG0459	protein refolding
DFR85_RS26555	COG0018	arginyl-trna synthetase
DFR85_RS26580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFR85_RS26585	COG0252	asparaginase activity
DFR85_RS26615	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
DFR85_RS26665	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DFR85_RS26665	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DFR85_RS26680	COG0154	amidase activity
DFR85_RS26685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFR85_RS26690	COG1324	tolerance protein
DFR85_RS26700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DFR85_RS26725	COG1110	DNA topoisomerase II activity
DFR85_RS26755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DFR85_RS26770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DFR85_RS26775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DFR85_RS26785	COG2084	Dehydrogenase
DFR85_RS26795	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS26805	COG0528	UMP kinase activity
DFR85_RS26815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFR85_RS26920	COG2271	Major facilitator Superfamily
DFR85_RS26935	COG0589	response to stress
DFR85_RS26945	COG3387	PFAM Glycoside hydrolase 15-related
DFR85_RS26950	COG0438	transferase activity, transferring glycosyl groups
DFR85_RS26985	COG0004	ammonium transporteR
DFR85_RS27005	COG1185	polyribonucleotide nucleotidyltransferase activity
DFR85_RS27040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DFR85_RS27050	COG1234	tRNA 3'-trailer cleavage
DFR85_RS27065	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DFR85_RS27090	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DFR85_RS27095	COG0725	ABC transporter, periplasmic molybdate-binding protein
DFR85_RS27100	COG0300	oxidoreductase activity
DFR85_RS27120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DFR85_RS27120	COG1213	nucleotidyl transferase
DFR85_RS27125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DFR85_RS27130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DFR85_RS27145	COG0045	succinate-CoA ligase (ADP-forming) activity
DFR85_RS27160	COG0813	purine-nucleoside phosphorylase activity
DFR85_RS27165	COG1078	dGTPase activity
DFR85_RS27195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DFR85_RS27225	COG0123	including yeast histone deacetylase and acetoin utilization protein
DFR85_RS27260	COG2210	Belongs to the sulfur carrier protein TusA family
DFR85_RS27265	COG0425	Belongs to the sulfur carrier protein TusA family
DFR85_RS27280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR85_RS27295	COG2048	Heterodisulfide reductase, subunit B
DFR85_RS27300	COG2149	membrane
DFR85_RS27305	COG0530	calcium, potassium:sodium antiporter activity
DFR85_RS27320	COG0277	FAD linked oxidase domain protein
DFR85_RS27365	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DFR85_RS27420	COG1335	isochorismatase
DFR85_RS27465	COG2814	Major facilitator Superfamily
DFR85_RS27490	COG1063	alcohol dehydrogenase
DFR85_RS27510	COG0251	oxidation-reduction process
DFR85_RS27555	COG0149	triose-phosphate isomerase activity
DFR85_RS27570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DFR85_RS27575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DFR85_RS27580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DFR85_RS27595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS27610	COG0531	amino acid
DFR85_RS27615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS27620	COG0114	fumarate hydratase activity
DFR85_RS27630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS27660	COG0509	glycine decarboxylation via glycine cleavage system
DFR85_RS27665	COG0095	Lipoate-protein ligase
DFR85_RS27705	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DFR85_RS27710	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DFR85_RS27760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DFR85_RS27775	COG1131	(ABC) transporter
DFR85_RS27800	COG0501	Belongs to the peptidase M48B family
DFR85_RS27840	COG1720	tRNA m6t6A37 methyltransferase activity
DFR85_RS27855	COG3511	phospholipase C
DFR85_RS27860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS27875	COG1139	Iron-sulfur cluster binding protein
DFR85_RS27890	COG1091	dTDP-4-dehydrorhamnose reductase activity
DFR85_RS27915	COG0667	Aldo Keto reductase
DFR85_RS27985	COG1518	maintenance of DNA repeat elements
DFR85_RS28025	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DFR85_RS28085	COG2151	metal-sulfur cluster biosynthetic enzyme
DFR85_RS28100	COG0574	Belongs to the PEP-utilizing enzyme family
DFR85_RS28100	COG3848	Pyruvate phosphate dikinase
DFR85_RS28115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DFR85_RS28140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS28145	COG0641	radical SAM
DFR85_RS28150	COG0535	radical SAM domain protein
DFR85_RS28160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DFR85_RS28160	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DFR85_RS28170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DFR85_RS28325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR85_RS28335	COG0174	glutamine synthetase
DFR85_RS28345	COG1132	(ABC) transporter
DFR85_RS28355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DFR85_RS28375	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS28380	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DFR85_RS28380	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS28390	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DFR85_RS28400	COG2814	Major facilitator Superfamily
DFR85_RS28435	COG4948	Mandelate Racemase Muconate Lactonizing
DFR85_RS28470	COG1802	Transcriptional regulator
DFR85_RS28480	COG2721	sulfolactate sulfo-lyase activity
DFR85_RS28485	COG2721	sulfolactate sulfo-lyase activity
DFR85_RS28490	COG2271	Major facilitator Superfamily
DFR85_RS28495	COG2814	Major facilitator Superfamily
DFR85_RS28500	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS28505	COG1012	belongs to the aldehyde dehydrogenase family
DFR85_RS28510	COG4948	Mandelate Racemase Muconate Lactonizing
DFR85_RS28515	COG1312	Catalyzes the dehydration of D-mannonate
DFR85_RS28520	COG3386	PFAM SMP-30 Gluconolaconase
DFR85_RS28525	COG0395	ABC-type sugar transport system, permease component
DFR85_RS28530	COG1175	transmembrane transport
DFR85_RS28550	COG3842	ATPase activity
DFR85_RS28620	COG0509	glycine decarboxylation via glycine cleavage system
DFR85_RS28630	COG0095	Lipoate-protein ligase
DFR85_RS28635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DFR85_RS28640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DFR85_RS28670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DFR85_RS28675	COG0477	Major facilitator Superfamily
DFR85_RS28685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DFR85_RS28750	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DFR85_RS28755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS28805	COG3383	formate dehydrogenase (NAD+) activity
DFR85_RS28820	COG0477	Major facilitator Superfamily
DFR85_RS28835	COG0517	IMP dehydrogenase activity
DFR85_RS28915	COG1078	dGTPase activity
DFR85_RS28970	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DFR85_RS28980	COG1518	maintenance of DNA repeat elements
DFR85_RS29050	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DFR85_RS29135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DFR85_RS29155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DFR85_RS29175	COG1201	RNA secondary structure unwinding
DFR85_RS29190	COG0515	serine threonine protein kinase
DFR85_RS29240	COG1489	DNA binding
DFR85_RS29245	COG1401	restriction endodeoxyribonuclease activity
DFR85_RS29280	COG2814	Major facilitator Superfamily
DFR85_RS29330	COG1337	RAMP superfamily
DFR85_RS29370	COG1056	cytidyltransferase-related domain
DFR85_RS29370	COG1051	belongs to the nudix hydrolase family
DFR85_RS29380	COG0450	alkyl hydroperoxide reductase
DFR85_RS29390	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DFR85_RS29500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DFR85_RS29510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS29655	COG1960	acyl-CoA dehydrogenase activity
DFR85_RS29665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DFR85_RS29695	COG0437	4 iron, 4 sulfur cluster binding
DFR85_RS29700	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DFR85_RS29705	COG1144	Oxidoreductase
DFR85_RS29710	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS29715	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR85_RS29735	COG1131	(ABC) transporter
DFR85_RS29765	COG1131	(ABC) transporter
DFR85_RS29800	COG3383	formate dehydrogenase (NAD+) activity
DFR85_RS29810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DFR85_RS29895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DFR85_RS29900	COG1960	acyl-CoA dehydrogenase activity
DFR85_RS29950	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DFR85_RS29960	COG1733	regulation of RNA biosynthetic process
DFR85_RS29980	COG0409	Hydrogenase expression formation protein
DFR85_RS29985	COG0298	carbon dioxide binding
DFR85_RS30015	COG0531	amino acid
DFR85_RS30085	COG0469	pyruvate kinase activity
DFR85_RS30095	COG0179	Fumarylacetoacetate (FAA) hydrolase
DFR85_RS30100	COG0598	Magnesium transport protein CorA
DFR85_RS30130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DFR85_RS30135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR85_RS30140	COG0477	Major facilitator Superfamily
DFR85_RS30145	COG1846	Transcriptional regulator
DFR85_RS30165	COG2151	metal-sulfur cluster biosynthetic enzyme
DFR85_RS30190	COG3350	monooxygenase activity
DFR85_RS30230	COG1012	belongs to the aldehyde dehydrogenase family
DFR85_RS30235	COG0028	Belongs to the TPP enzyme family
DFR85_RS30275	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS30280	COG0667	Aldo Keto reductase
DFR85_RS30290	COG0412	Dienelactone hydrolase
DFR85_RS30295	COG0500	methyltransferase
DFR85_RS30300	COG2814	Major facilitator Superfamily
DFR85_RS30310	COG1131	(ABC) transporter
DFR85_RS30345	COG2084	Dehydrogenase
DFR85_RS30370	COG0477	Major facilitator Superfamily
DFR85_RS30375	COG1846	Transcriptional regulator
DFR85_RS30395	COG1012	belongs to the aldehyde dehydrogenase family
DFR85_RS30410	COG4948	Mandelate Racemase Muconate Lactonizing
DFR85_RS30425	COG1024	Enoyl-CoA hydratase
DFR85_RS30430	COG1960	acyl-CoA dehydrogenase activity
DFR85_RS30435	COG0318	PFAM AMP-dependent synthetase and ligase
DFR85_RS30470	COG2086	electron transfer activity
DFR85_RS30480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS30545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DFR85_RS30550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DFR85_RS30555	COG1012	belongs to the aldehyde dehydrogenase family
DFR85_RS30565	COG0318	PFAM AMP-dependent synthetase and ligase
DFR85_RS30585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS30595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DFR85_RS30600	COG2124	cytochrome p450
DFR85_RS30610	COG0022	dehydrogenase e1 component
DFR85_RS30615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DFR85_RS30620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR85_RS30645	COG1051	belongs to the nudix hydrolase family
DFR85_RS30645	COG1056	cytidyltransferase-related domain
DFR85_RS30655	COG1832	CoA-binding protein
DFR85_RS30680	COG0277	FAD linked oxidase domain protein
DFR85_RS30720	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DFR85_RS30750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS30775	COG1024	Enoyl-CoA hydratase
DFR85_RS30780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS30795	COG4948	Mandelate Racemase Muconate Lactonizing
DFR85_RS30800	COG0318	PFAM AMP-dependent synthetase and ligase
DFR85_RS30805	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS30810	COG2271	Major facilitator Superfamily
DFR85_RS30820	COG1028	Short-chain dehydrogenase reductase Sdr
DFR85_RS30830	COG1131	(ABC) transporter
DFR85_RS30860	COG1233	COG1233 Phytoene dehydrogenase and related
DFR85_RS30870	COG0393	Putative heavy-metal-binding
DFR85_RS30900	COG0477	Major facilitator Superfamily
DFR85_RS30910	COG2814	Major facilitator Superfamily
DFR85_RS30915	COG2226	methyltransferase
DFR85_RS30985	COG0477	Major facilitator Superfamily
DFR85_RS30990	COG4948	Mandelate Racemase Muconate Lactonizing
DFR85_RS31015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DFR85_RS31025	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DFR85_RS31035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DFR85_RS31085	COG4274	PFAM GYD family protein
DFR85_RS31115	COG0426	domain, Protein
DFR85_RS31125	COG0281	malic enzyme
DFR85_RS31150	COG0183	Belongs to the thiolase family
DFR85_RS31175	COG0318	PFAM AMP-dependent synthetase and ligase
DFR85_RS31205	COG1024	Enoyl-CoA hydratase
DFR85_RS31210	COG1024	Enoyl-CoA hydratase
DFR85_RS31230	COG0589	response to stress
DFR85_RS31240	COG0179	Fumarylacetoacetate (FAA) hydrolase
DFR85_RS31250	COG2368	4-hydroxyphenylacetate
DFR85_RS31285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DFR85_RS31290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS31305	COG3842	ATPase activity
DFR85_RS31320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS31345	COG2271	Major facilitator Superfamily
DFR85_RS31350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR85_RS31370	COG0425	Belongs to the sulfur carrier protein TusA family
DFR85_RS31380	COG0425	Belongs to the sulfur carrier protein TusA family
DFR85_RS31450	COG0517	IMP dehydrogenase activity
DFR85_RS31450	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DFR85_RS31465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DFR85_RS31470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR85_RS31515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR85_RS31525	COG0604	alcohol dehydrogenase
DFR85_RS31535	COG0450	alkyl hydroperoxide reductase
DFR85_RS31545	COG1960	acyl-CoA dehydrogenase activity
DFR85_RS31590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR85_RS31650	COG0372	Belongs to the citrate synthase family
DFR85_RS31655	COG0516	GMP reductase activity
DFR85_RS31655	COG0517	IMP dehydrogenase activity
DFR85_RS31660	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DFR85_RS31665	COG2079	MmgE PrpD family protein