locus-tag	class	description
B6F84_RS00040	COG1337	RAMP superfamily
B6F84_RS00060	COG1203	CRISPR-associated helicase, Cas3
B6F84_RS00195	COG1111	helicase
B6F84_RS00195	COG1205	dead DEAH box helicase
B6F84_RS00205	COG1473	amidohydrolase
B6F84_RS00230	COG1725	Transcriptional regulator
B6F84_RS00245	COG0640	Transcriptional regulator
B6F84_RS00260	COG3842	ATPase activity
B6F84_RS00270	COG1175	transmembrane transport
B6F84_RS00315	COG1832	CoA-binding protein
B6F84_RS00350	COG0095	Lipoate-protein ligase
B6F84_RS00370	COG3511	phospholipase C
B6F84_RS00390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6F84_RS00395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B6F84_RS00420	COG1215	transferase activity, transferring glycosyl groups
B6F84_RS00445	COG0297	glycogen (starch) synthase activity
B6F84_RS00505	COG0022	dehydrogenase e1 component
B6F84_RS00510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B6F84_RS00525	COG0183	Belongs to the thiolase family
B6F84_RS00530	COG1024	Enoyl-CoA hydratase
B6F84_RS00535	COG1024	Enoyl-CoA hydratase
B6F84_RS00555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6F84_RS00595	COG2124	cytochrome p450
B6F84_RS00600	COG2814	Major facilitator Superfamily
B6F84_RS00620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6F84_RS00675	COG1129	ABC transporter
B6F84_RS00680	COG1172	Belongs to the binding-protein-dependent transport system permease family
B6F84_RS00690	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_RS00710	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6F84_RS00735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B6F84_RS00740	COG1960	acyl-CoA dehydrogenase activity
B6F84_RS00750	COG1960	acyl-CoA dehydrogenase activity
B6F84_RS00775	COG2151	metal-sulfur cluster biosynthetic enzyme
B6F84_RS00800	COG3350	monooxygenase activity
B6F84_RS00845	COG4106	trans-aconitate 2-methyltransferase activity
B6F84_RS00850	COG2050	protein possibly involved in aromatic compounds catabolism
B6F84_RS00870	COG2086	electron transfer activity
B6F84_RS00875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_RS00880	COG1960	acyl-CoA dehydrogenase activity
B6F84_RS00905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_RS00925	COG2301	Belongs to the HpcH HpaI aldolase family
B6F84_RS00935	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6F84_RS00940	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6F84_RS00945	COG1144	Oxidoreductase
B6F84_RS00970	COG0437	4 iron, 4 sulfur cluster binding
B6F84_RS00980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B6F84_RS00995	COG1177	transmembrane transport
B6F84_RS01020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_RS01025	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6F84_RS01055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B6F84_RS01125	COG0531	amino acid
B6F84_RS01135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_RS01145	COG1846	Transcriptional regulator
B6F84_RS01150	COG2814	Major facilitator Superfamily
B6F84_RS01180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6F84_RS01195	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B6F84_RS01200	COG1215	transferase activity, transferring glycosyl groups
B6F84_RS01235	COG0243	molybdopterin cofactor binding
B6F84_RS01240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_RS01250	COG2084	Dehydrogenase
B6F84_RS01270	COG1592	Rubrerythrin
B6F84_RS01275	COG0028	Belongs to the TPP enzyme family
B6F84_RS01280	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6F84_RS01295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_RS01335	COG2079	MmgE PrpD family protein
B6F84_RS01340	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B6F84_RS01345	COG0516	GMP reductase activity
B6F84_RS01345	COG0517	IMP dehydrogenase activity
B6F84_RS01350	COG0372	Belongs to the citrate synthase family
B6F84_RS01370	COG0604	alcohol dehydrogenase
B6F84_RS01400	COG0525	valine-tRNA ligase activity
B6F84_RS01430	COG2814	Major facilitator Superfamily
B6F84_RS01440	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_RS01460	COG2271	Major facilitator Superfamily
B6F84_RS01490	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B6F84_RS01525	COG0114	fumarate hydratase activity
B6F84_RS01580	COG2860	membrane
B6F84_RS01590	COG1131	(ABC) transporter
B6F84_RS01605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6F84_RS01605	COG0045	succinate-CoA ligase (ADP-forming) activity
B6F84_RS01605	COG1042	CoA-binding domain protein
B6F84_RS01615	COG0531	amino acid
B6F84_RS01620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_RS01655	COG1137	ATPase activity
B6F84_RS01670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B6F84_RS01675	COG0066	3-isopropylmalate dehydratase activity
B6F84_RS01680	COG0778	Nitroreductase
B6F84_RS01710	COG0708	Exodeoxyribonuclease III
B6F84_RS01725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B6F84_RS01730	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B6F84_RS01730	COG0352	thiamine-phosphate diphosphorylase activity
B6F84_RS01730	COG0351	phosphomethylpyrimidine kinase
B6F84_RS01745	COG0157	Belongs to the NadC ModD family
B6F84_RS01755	COG5599	Phosphatase
B6F84_RS01760	COG1515	deoxyribonuclease V activity
B6F84_RS01775	COG0450	alkyl hydroperoxide reductase
B6F84_RS01790	COG0372	Belongs to the citrate synthase family
B6F84_RS01820	COG4581	dead DEAH box helicase
B6F84_RS01825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6F84_RS01835	COG0439	Biotin carboxylase
B6F84_RS01845	COG1116	anion transmembrane transporter activity
B6F84_RS01855	COG0513	Belongs to the DEAD box helicase family
B6F84_RS01885	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6F84_RS01895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6F84_RS01905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_RS01940	COG2814	Major facilitator Superfamily
B6F84_RS01955	COG0671	phosphoesterase, PA-phosphatase related
B6F84_RS01970	COG0243	molybdopterin cofactor binding
B6F84_RS01995	COG1215	transferase activity, transferring glycosyl groups
B6F84_RS02000	COG1215	transferase activity, transferring glycosyl groups
B6F84_RS02015	COG1201	RNA secondary structure unwinding
B6F84_RS02060	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B6F84_RS02065	COG0123	including yeast histone deacetylase and acetoin utilization protein
B6F84_RS02070	COG0516	GMP reductase activity
B6F84_RS02070	COG0517	IMP dehydrogenase activity
B6F84_RS02075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6F84_RS02100	COG1192	Involved in chromosome partitioning
B6F84_RS02140	COG1131	(ABC) transporter
B6F84_RS02150	COG1024	Enoyl-CoA hydratase
B6F84_RS02155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_RS02175	COG0438	transferase activity, transferring glycosyl groups
B6F84_RS02180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6F84_RS02220	COG1331	Highly conserved protein containing a thioredoxin domain
B6F84_RS02230	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B6F84_RS02285	COG0330	HflC and HflK could
B6F84_RS02310	COG2154	pterin-4-alpha-carbinolamine dehydratase
B6F84_RS02325	COG0538	isocitrate dehydrogenase activity
B6F84_RS02365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B6F84_RS02380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6F84_RS02380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B6F84_RS02385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B6F84_RS02400	COG3253	May function as heme-dependent peroxidase
B6F84_RS02415	COG0537	adenosine 5'-monophosphoramidase activity
B6F84_RS02430	COG0154	amidase activity
B6F84_RS02435	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
B6F84_RS02440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B6F84_RS02445	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B6F84_RS02445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B6F84_RS02465	COG0497	DNA recombination
B6F84_RS02490	COG0517	IMP dehydrogenase activity
B6F84_RS02490	COG0516	GMP reductase activity
B6F84_RS02500	COG0735	belongs to the Fur family
B6F84_RS02505	COG1957	nucleoside hydrolase
B6F84_RS02605	COG0492	ferredoxin-NADP+ reductase activity
B6F84_RS02615	COG2814	Major facilitator Superfamily
B6F84_RS02620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B6F84_RS02640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B6F84_RS02650	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B6F84_RS02660	COG1011	Hydrolase
B6F84_RS02665	COG0561	phosphatase activity
B6F84_RS02715	COG0516	GMP reductase activity
B6F84_RS02720	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B6F84_RS02725	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6F84_RS02745	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B6F84_RS02755	COG0297	glycogen (starch) synthase activity
B6F84_RS02775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6F84_RS02785	COG0469	pyruvate kinase activity
B6F84_RS02805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6F84_RS02810	COG0546	phosphoglycolate phosphatase activity
B6F84_RS02820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B6F84_RS02890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B6F84_RS02895	COG1051	belongs to the nudix hydrolase family
B6F84_RS02900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_RS02905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6F84_RS02920	COG0430	RNA-3'-phosphate cyclase activity
B6F84_RS02985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6F84_RS03015	COG0346	lactoylglutathione lyase activity
B6F84_RS03020	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6F84_RS03020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6F84_RS03025	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B6F84_RS03040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_RS03045	COG0483	inositol monophosphate 1-phosphatase activity
B6F84_RS03050	COG0492	ferredoxin-NADP+ reductase activity
B6F84_RS03095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6F84_RS03100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B6F84_RS03125	COG4555	ABC transporter
B6F84_RS03135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B6F84_RS03165	COG0351	phosphomethylpyrimidine kinase
B6F84_RS03170	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
B6F84_RS03185	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B6F84_RS03220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6F84_RS03225	COG0183	Belongs to the thiolase family
B6F84_RS03265	COG0626	cystathionine gamma-synthase activity
B6F84_RS03270	COG0083	homoserine kinase activity
B6F84_RS03290	COG0714	Associated with various cellular activities
B6F84_RS03295	COG2304	oxidoreductase activity
B6F84_RS03320	COG0647	UMP catabolic process
B6F84_RS03350	COG1446	asparaginase
B6F84_RS03365	COG1522	sequence-specific DNA binding
B6F84_RS03370	COG0189	ligase activity
B6F84_RS03370	COG0569	domain protein
B6F84_RS03375	COG0142	geranyltranstransferase activity
B6F84_RS03385	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B6F84_RS03390	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B6F84_RS03420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B6F84_RS03455	COG4555	ABC transporter
B6F84_RS03480	COG2409	Drug exporters of the RND superfamily
B6F84_RS03495	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B6F84_RS03510	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B6F84_RS03560	COG2308	Evidence 4 Homologs of previously reported genes of
B6F84_RS03565	COG3387	PFAM Glycoside hydrolase 15-related
B6F84_RS03575	COG2723	6-phospho-beta-galactosidase activity
B6F84_RS03590	COG0477	Major facilitator Superfamily
B6F84_RS03595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6F84_RS03625	COG0531	amino acid
B6F84_RS03655	COG0477	Major facilitator Superfamily
B6F84_RS03685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B6F84_RS03690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6F84_RS03695	COG1121	(ABC) transporter
B6F84_RS03705	COG0519	Catalyzes the synthesis of GMP from XMP
B6F84_RS03715	COG2814	Major facilitator Superfamily
B6F84_RS03725	COG0673	inositol 2-dehydrogenase activity
B6F84_RS03735	COG0531	amino acid
B6F84_RS03765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B6F84_RS03835	COG0675	Transposase, IS605 OrfB family
B6F84_RS03840	COG0589	response to stress
B6F84_RS03870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6F84_RS03885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B6F84_RS03885	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6F84_RS03890	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6F84_RS03900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6F84_RS03910	COG1733	regulation of RNA biosynthetic process
B6F84_RS03930	COG1131	(ABC) transporter
B6F84_RS03935	COG1129	ABC transporter
B6F84_RS03945	COG0531	amino acid
B6F84_RS03955	COG3383	formate dehydrogenase (NAD+) activity
B6F84_RS03965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B6F84_RS03995	COG1012	belongs to the aldehyde dehydrogenase family
B6F84_RS04075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B6F84_RS04095	COG0309	Hydrogenase expression formation protein (HypE)
B6F84_RS04105	COG0409	Hydrogenase expression formation protein
B6F84_RS04120	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B6F84_RS04165	COG2226	methyltransferase
B6F84_RS04215	COG1215	transferase activity, transferring glycosyl groups
B6F84_RS04255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B6F84_RS04260	COG2226	methyltransferase
B6F84_RS04305	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B6F84_RS04385	COG0298	carbon dioxide binding
B6F84_RS04390	COG0409	Hydrogenase expression formation protein
B6F84_RS04410	COG1733	regulation of RNA biosynthetic process
B6F84_RS04445	COG0298	carbon dioxide binding
B6F84_RS04530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6F84_RS04530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B6F84_RS04535	COG0167	dihydroorotate dehydrogenase activity
B6F84_RS04555	COG1953	Uracil, thiamine, allantoin
B6F84_RS04580	COG2235	arginine
B6F84_RS04590	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
B6F84_RS04595	COG0402	S-adenosylhomocysteine deaminase activity
B6F84_RS04600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6F84_RS04605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6F84_RS04610	COG0477	Major facilitator Superfamily
B6F84_RS04620	COG4638	Rieske (2fe-2S)
B6F84_RS04630	COG0174	glutamine synthetase
B6F84_RS04660	COG0531	amino acid
B6F84_RS04665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6F84_RS04670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6F84_RS04695	COG0402	S-adenosylhomocysteine deaminase activity
B6F84_RS04700	COG0277	FAD linked oxidase domain protein
B6F84_RS04705	COG0277	FAD linked oxidase domain protein
B6F84_RS04715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6F84_RS04720	COG0243	molybdopterin cofactor binding
B6F84_RS04725	COG1017	nitric oxide dioxygenase activity
B6F84_RS04750	COG0402	S-adenosylhomocysteine deaminase activity
B6F84_RS04780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B6F84_RS04795	COG0832	Belongs to the urease beta subunit family
B6F84_RS04795	COG0831	urea catabolic process
B6F84_RS04815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6F84_RS04830	COG1953	Uracil, thiamine, allantoin
B6F84_RS04835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6F84_RS04840	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B6F84_RS04890	COG4608	Belongs to the ABC transporter superfamily
B6F84_RS04895	COG0444	Belongs to the ABC transporter superfamily
B6F84_RS04900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6F84_RS04905	COG0601	transmembrane transport
B6F84_RS04915	COG4948	Mandelate Racemase Muconate Lactonizing
B6F84_RS04920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6F84_RS04950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_RS04965	COG1132	(ABC) transporter
B6F84_RS04970	COG4948	Mandelate Racemase Muconate Lactonizing
B6F84_RS04975	COG1012	belongs to the aldehyde dehydrogenase family
B6F84_RS04980	COG3386	PFAM SMP-30 Gluconolaconase
B6F84_RS04985	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_RS04990	COG1802	Transcriptional regulator
B6F84_RS05000	COG2721	sulfolactate sulfo-lyase activity
B6F84_RS05005	COG2721	sulfolactate sulfo-lyase activity
B6F84_RS05010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6F84_RS05015	COG2814	Major facilitator Superfamily
B6F84_RS05025	COG4608	Belongs to the ABC transporter superfamily
B6F84_RS05035	COG0601	transmembrane transport
B6F84_RS05045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6F84_RS05090	COG2814	Major facilitator Superfamily
B6F84_RS05095	COG1228	amidohydrolase
B6F84_RS05100	COG2814	Major facilitator Superfamily
B6F84_RS05120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6F84_RS05145	COG0444	Belongs to the ABC transporter superfamily
B6F84_RS05160	COG2153	protein acetylation
B6F84_RS05165	COG0281	malic enzyme
B6F84_RS05170	COG0531	amino acid
B6F84_RS05180	COG0656	L-ascorbic acid biosynthetic process
B6F84_RS05190	COG3608	succinylglutamate desuccinylase aspartoacylase
B6F84_RS05190	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B6F84_RS05200	COG1454	alcohol dehydrogenase
B6F84_RS05205	COG0675	Transposase, IS605 OrfB family
B6F84_RS05225	COG2814	Major facilitator Superfamily
B6F84_RS05270	COG3848	Pyruvate phosphate dikinase
B6F84_RS05270	COG0574	Belongs to the PEP-utilizing enzyme family
B6F84_RS05280	COG0450	alkyl hydroperoxide reductase
B6F84_RS05290	COG0318	PFAM AMP-dependent synthetase and ligase
B6F84_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_RS05325	COG2046	Belongs to the sulfate adenylyltransferase family
B6F84_RS05335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6F84_RS05340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6F84_RS05350	COG1960	acyl-CoA dehydrogenase activity
B6F84_RS05355	COG0318	PFAM AMP-dependent synthetase and ligase
B6F84_RS05360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B6F84_RS05370	COG0667	Aldo Keto reductase
B6F84_RS05375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B6F84_RS05385	COG2368	4-hydroxyphenylacetate
B6F84_RS05395	COG0477	Major facilitator Superfamily
B6F84_RS05410	COG1056	cytidyltransferase-related domain
B6F84_RS05410	COG1051	belongs to the nudix hydrolase family
B6F84_RS05430	COG0318	PFAM AMP-dependent synthetase and ligase
B6F84_RS05440	COG1024	Enoyl-CoA hydratase
B6F84_RS05450	COG0183	Belongs to the thiolase family
B6F84_RS05455	COG1960	acyl-CoA dehydrogenase activity
B6F84_RS05460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6F84_RS05465	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B6F84_RS05470	COG1012	belongs to the aldehyde dehydrogenase family
B6F84_RS05485	COG0028	Belongs to the TPP enzyme family
B6F84_RS05490	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_RS05495	COG0318	PFAM AMP-dependent synthetase and ligase
B6F84_RS05535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_RS05540	COG0517	IMP dehydrogenase activity
B6F84_RS05540	COG0516	GMP reductase activity
B6F84_RS05560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_RS05565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_RS05625	COG0604	alcohol dehydrogenase
B6F84_RS05630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6F84_RS05640	COG0412	Dienelactone hydrolase
B6F84_RS05650	COG1312	Catalyzes the dehydration of D-mannonate
B6F84_RS05655	COG1139	Iron-sulfur cluster binding protein
B6F84_RS05665	COG2271	Major facilitator Superfamily
B6F84_RS05680	COG4948	Mandelate Racemase Muconate Lactonizing
B6F84_RS05685	COG2814	Major facilitator Superfamily
B6F84_RS05690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B6F84_RS05700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6F84_RS05720	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
B6F84_RS05740	COG1233	COG1233 Phytoene dehydrogenase and related
B6F84_RS05750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6F84_RS05755	COG0731	radical SAM domain protein
B6F84_RS05755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6F84_RS05765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6F84_RS05770	COG0516	GMP reductase activity
B6F84_RS05770	COG0517	IMP dehydrogenase activity
B6F84_RS05785	COG1505	serine-type exopeptidase activity
B6F84_RS05805	COG2814	Major facilitator Superfamily
B6F84_RS05810	COG0561	phosphatase activity
B6F84_RS05820	COG0277	FAD linked oxidase domain protein
B6F84_RS05825	COG2814	Major facilitator Superfamily
B6F84_RS05850	COG3387	PFAM Glycoside hydrolase 15-related
B6F84_RS05890	COG0415	Belongs to the DNA photolyase family
B6F84_RS05905	COG0477	Major facilitator Superfamily
B6F84_RS05910	COG1953	Uracil, thiamine, allantoin
B6F84_RS05915	COG1741	Belongs to the pirin family
B6F84_RS05935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B6F84_RS05950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6F84_RS05955	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6F84_RS05965	COG2062	phosphohistidine phosphatase, SixA
B6F84_RS05970	COG0028	Belongs to the TPP enzyme family
B6F84_RS05995	COG0477	Major facilitator Superfamily
B6F84_RS06000	COG1011	Hydrolase
B6F84_RS06010	COG0174	glutamine synthetase
B6F84_RS06020	COG2271	Major facilitator Superfamily
B6F84_RS06045	COG0109	protoheme IX farnesyltransferase activity
B6F84_RS06080	COG1960	acyl-CoA dehydrogenase activity
B6F84_RS06085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B6F84_RS06095	COG1607	acyl-coa hydrolase
B6F84_RS06115	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6F84_RS06125	COG2222	sugar isomerase
B6F84_RS06130	COG0215	cysteine-tRNA ligase activity
B6F84_RS06145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B6F84_RS06155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6F84_RS06160	COG1028	Short-chain dehydrogenase reductase Sdr
B6F84_RS06165	COG1573	uracil-dna glycosylase
B6F84_RS06195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6F84_RS06215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6F84_RS06220	COG1703	isobutyryl-CoA mutase activity
B6F84_RS06230	COG0596	Alpha beta hydrolase
B6F84_RS06250	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
B6F84_RS06255	COG1881	PFAM PEBP family protein
B6F84_RS06265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B6F84_RS06265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6F84_RS06270	COG0315	cyclic pyranopterin monophosphate synthase activity
B6F84_RS06325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6F84_RS06355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B6F84_RS06360	COG1444	tRNA N-acetyltransferase activity
B6F84_RS06380	COG0589	response to stress
B6F84_RS06385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6F84_RS06390	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B6F84_RS06390	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B6F84_RS06395	COG0009	L-threonylcarbamoyladenylate synthase
B6F84_RS06400	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6F84_RS06405	COG2379	hydroxypyruvate reductase
B6F84_RS06415	COG1321	iron dependent repressor
B6F84_RS06445	COG1763	Mo-molybdopterin cofactor biosynthetic process
B6F84_RS06450	COG0303	'Molybdopterin
B6F84_RS06455	COG0746	molybdenum cofactor guanylyltransferase activity
B6F84_RS06470	COG0402	S-adenosylhomocysteine deaminase activity
B6F84_RS06500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B6F84_RS06520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6F84_RS06545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B6F84_RS06555	COG1215	transferase activity, transferring glycosyl groups
B6F84_RS06560	COG1201	RNA secondary structure unwinding
B6F84_RS06570	COG0517	IMP dehydrogenase activity
B6F84_RS06570	COG0617	tRNA 3'-terminal CCA addition
B6F84_RS06570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B6F84_RS06595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6F84_RS06600	COG1058	Belongs to the CinA family
B6F84_RS06600	COG1546	Belongs to the CinA family
B6F84_RS06615	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B6F84_RS06620	COG0024	Methionine aminopeptidase
B6F84_RS06650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6F84_RS06655	COG1358	cellular component organization or biogenesis
B6F84_RS06670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6F84_RS06675	COG0142	geranyltranstransferase activity
B6F84_RS06680	COG1304	FMN binding
B6F84_RS06695	COG1355	regulation of microtubule-based process
B6F84_RS06700	COG0052	Belongs to the universal ribosomal protein uS2 family
B6F84_RS06710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B6F84_RS06715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B6F84_RS06735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B6F84_RS06740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B6F84_RS06750	COG0432	Pfam Uncharacterised protein family UPF0047
B6F84_RS06760	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B6F84_RS06770	COG0417	DNA replication proofreading
B6F84_RS06805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6F84_RS06825	COG3276	selenocysteine insertion sequence binding
B6F84_RS06840	COG0023	Translation Initiation Factor
B6F84_RS06850	COG0010	Belongs to the arginase family
B6F84_RS06855	COG0423	glycine-tRNA ligase activity
B6F84_RS06885	COG0163	prenyltransferase activity
B6F84_RS06895	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
B6F84_RS06910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6F84_RS06915	COG2815	serine threonine protein kinase
B6F84_RS06915	COG0515	serine threonine protein kinase
B6F84_RS06920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6F84_RS06925	COG0667	Aldo Keto reductase
B6F84_RS06970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_RS06975	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
B6F84_RS06990	COG0557	exoribonuclease II activity
B6F84_RS07025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B6F84_RS07040	COG1797	cobyrinic acid a,c-diamide synthase activity
B6F84_RS07055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6F84_RS07055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B6F84_RS07065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6F84_RS07095	COG1201	RNA secondary structure unwinding
B6F84_RS07110	COG2813	Specifically methylates the guanine in position
B6F84_RS07115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6F84_RS07120	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6F84_RS07135	COG0051	transcription antitermination factor activity, RNA binding
B6F84_RS07140	COG2895	sulfate adenylyltransferase (ATP) activity
B6F84_RS07145	COG0049	tRNA binding
B6F84_RS07170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6F84_RS07175	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6F84_RS07180	COG0085	RNA polymerase activity
B6F84_RS07190	COG0281	malic enzyme
B6F84_RS07195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B6F84_RS07215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B6F84_RS07225	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6F84_RS07240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6F84_RS07245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6F84_RS07260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B6F84_RS07275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B6F84_RS07280	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B6F84_RS07290	COG0077	Prephenate dehydratase
B6F84_RS07290	COG1605	Chorismate mutase
B6F84_RS07295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B6F84_RS07330	COG1051	belongs to the nudix hydrolase family
B6F84_RS07330	COG1056	cytidyltransferase-related domain
B6F84_RS07335	COG1607	acyl-coa hydrolase
B6F84_RS07385	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B6F84_RS07400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B6F84_RS07410	COG1121	(ABC) transporter
B6F84_RS07415	COG1980	fructose-bisphosphate aldolase activity
B6F84_RS07490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_RS07500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6F84_RS07540	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B6F84_RS07585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6F84_RS07590	COG2264	protein methyltransferase activity
B6F84_RS07595	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B6F84_RS07605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6F84_RS07610	COG0012	GTP binding
B6F84_RS07650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B6F84_RS07655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B6F84_RS07680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6F84_RS07685	COG1011	Hydrolase
B6F84_RS07700	COG0473	3-isopropylmalate dehydrogenase activity
B6F84_RS07705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B6F84_RS07715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B6F84_RS07730	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6F84_RS07735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B6F84_RS07740	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B6F84_RS07745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B6F84_RS07750	COG0255	Belongs to the universal ribosomal protein uL29 family
B6F84_RS07765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B6F84_RS07770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B6F84_RS07780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6F84_RS07790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B6F84_RS07795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B6F84_RS07815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B6F84_RS07825	COG0200	Binds to the 23S rRNA
B6F84_RS07920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B6F84_RS07940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6F84_RS07960	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B6F84_RS07965	COG0504	CTP synthase activity
B6F84_RS07980	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
B6F84_RS08010	COG2078	PFAM AMMECR1 domain protein
B6F84_RS08025	COG0717	Belongs to the dCTP deaminase family
B6F84_RS08030	COG1793	dna ligase
B6F84_RS08040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6F84_RS08065	COG0181	hydroxymethylbilane synthase activity
B6F84_RS08070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6F84_RS08075	COG0113	porphobilinogen synthase activity
B6F84_RS08080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B6F84_RS08090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6F84_RS08090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6F84_RS08100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_RS08125	COG0017	Asparaginyl-tRNA synthetase
B6F84_RS08150	COG0028	Belongs to the TPP enzyme family
B6F84_RS08165	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B6F84_RS08170	COG1047	Peptidyl-prolyl cis-trans
B6F84_RS08175	COG0371	Dehydrogenase
B6F84_RS08180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B6F84_RS08235	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B6F84_RS08250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B6F84_RS08255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B6F84_RS08270	COG0189	ligase activity
B6F84_RS08275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6F84_RS08280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6F84_RS08285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6F84_RS08305	COG0517	IMP dehydrogenase activity
B6F84_RS08305	COG0516	GMP reductase activity
B6F84_RS08350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B6F84_RS08355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B6F84_RS08385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6F84_RS08390	COG0515	serine threonine protein kinase
B6F84_RS08395	COG0251	oxidation-reduction process
B6F84_RS08415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B6F84_RS08415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B6F84_RS08420	COG2239	Acts as a magnesium transporter
B6F84_RS08435	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B6F84_RS08440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B6F84_RS08485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B6F84_RS08560	COG1720	tRNA m6t6A37 methyltransferase activity
B6F84_RS08580	COG0037	tRNA processing
B6F84_RS08595	COG0513	Belongs to the DEAD box helicase family
B6F84_RS08680	COG0489	protein tyrosine kinase activity
B6F84_RS08720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6F84_RS08730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6F84_RS08745	COG4974	Belongs to the 'phage' integrase family
B6F84_RS08845	COG0438	transferase activity, transferring glycosyl groups
B6F84_RS08875	COG0275	rRNA processing
B6F84_RS08950	COG0275	rRNA processing
B6F84_RS09110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_RS09165	COG0438	transferase activity, transferring glycosyl groups
B6F84_RS09180	COG2848	UPF0210 protein
B6F84_RS09185	COG3830	Belongs to the UPF0237 family
B6F84_RS09230	COG1063	alcohol dehydrogenase
B6F84_RS09240	COG1131	(ABC) transporter
B6F84_RS09250	COG1914	H( )-stimulated, divalent metal cation uptake system
B6F84_RS09270	COG0477	Major facilitator Superfamily
B6F84_RS09280	COG0501	Belongs to the peptidase M48B family
B6F84_RS09295	COG2814	Major facilitator Superfamily
B6F84_RS09300	COG1968	undecaprenyl-diphosphatase activity
B6F84_RS09345	COG1215	transferase activity, transferring glycosyl groups
B6F84_RS09355	COG0352	thiamine-phosphate diphosphorylase activity
B6F84_RS09355	COG0351	phosphomethylpyrimidine kinase
B6F84_RS09360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6F84_RS09365	COG1234	tRNA 3'-trailer cleavage
B6F84_RS09390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6F84_RS09420	COG0501	Belongs to the peptidase M48B family
B6F84_RS09430	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B6F84_RS09445	COG0519	Catalyzes the synthesis of GMP from XMP
B6F84_RS09445	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B6F84_RS09450	COG0501	Belongs to the peptidase M48B family
B6F84_RS09455	COG0516	GMP reductase activity
B6F84_RS09455	COG0517	IMP dehydrogenase activity
B6F84_RS09470	COG1830	Aldolase
B6F84_RS09490	COG0405	Gamma-glutamyltransferase
B6F84_RS09505	COG1444	tRNA N-acetyltransferase activity
B6F84_RS09525	COG0589	response to stress
B6F84_RS09540	COG0864	Transcriptional regulator
B6F84_RS09555	COG0109	protoheme IX farnesyltransferase activity
B6F84_RS09565	COG1024	Enoyl-CoA hydratase
B6F84_RS09605	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6F84_RS09615	COG0189	ligase activity
B6F84_RS09635	COG0137	argininosuccinate synthase activity
B6F84_RS09650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6F84_RS09655	COG0151	Belongs to the GarS family
B6F84_RS09660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B6F84_RS09665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B6F84_RS09670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6F84_RS09675	COG0047	phosphoribosylformylglycinamidine synthase activity
B6F84_RS09685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6F84_RS09695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6F84_RS09700	COG0602	queuosine metabolic process
B6F84_RS09715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6F84_RS09745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B6F84_RS09750	COG0540	Belongs to the ATCase OTCase family
B6F84_RS09755	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B6F84_RS09770	COG0167	dihydroorotate dehydrogenase activity
B6F84_RS09790	COG1522	sequence-specific DNA binding
B6F84_RS09805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6F84_RS09810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B6F84_RS09815	COG2151	metal-sulfur cluster biosynthetic enzyme
B6F84_RS09825	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B6F84_RS09835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B6F84_RS09840	COG0107	imidazoleglycerol-phosphate synthase activity
B6F84_RS09845	COG0131	Imidazoleglycerol-phosphate dehydratase
B6F84_RS09850	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B6F84_RS09855	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B6F84_RS09860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6F84_RS09870	COG0495	leucyl-tRNA aminoacylation
B6F84_RS09875	COG2096	Adenosyltransferase
B6F84_RS09880	COG0037	tRNA processing
B6F84_RS09890	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B6F84_RS09905	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B6F84_RS09915	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B6F84_RS09920	COG0546	phosphoglycolate phosphatase activity
B6F84_RS09925	COG0028	Belongs to the TPP enzyme family
B6F84_RS09950	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B6F84_RS09955	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B6F84_RS09965	COG0442	prolyl-tRNA aminoacylation
B6F84_RS09980	COG1394	ATPase activity, coupled to movement of substances
B6F84_RS09990	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
B6F84_RS10010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6F84_RS10010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6F84_RS10045	COG0417	DNA replication proofreading
B6F84_RS10060	COG1260	myo-inositol-1-phosphate synthase
B6F84_RS10065	COG1007	ATP synthesis coupled electron transport
B6F84_RS10070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6F84_RS10075	COG0713	ATP synthesis coupled electron transport
B6F84_RS10085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6F84_RS10090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B6F84_RS10095	COG0649	NAD binding
B6F84_RS10100	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6F84_RS10110	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B6F84_RS10130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6F84_RS10165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B6F84_RS10180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6F84_RS10190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6F84_RS10195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B6F84_RS10200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B6F84_RS10205	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B6F84_RS10210	COG0077	Prephenate dehydratase
B6F84_RS10210	COG1605	Chorismate mutase
B6F84_RS10215	COG3958	Transketolase
B6F84_RS10220	COG3959	Transketolase, thiamine diphosphate binding domain
B6F84_RS10225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B6F84_RS10285	COG0069	glutamate synthase activity
B6F84_RS10290	COG0067	glutamate synthase
B6F84_RS10495	COG1185	polyribonucleotide nucleotidyltransferase activity
B6F84_RS10530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6F84_RS10540	COG1234	tRNA 3'-trailer cleavage
B6F84_RS10555	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B6F84_RS10740	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B6F84_RS10750	COG0300	oxidoreductase activity
B6F84_RS10755	COG0084	hydrolase, TatD family'
B6F84_RS10765	COG2423	ornithine cyclodeaminase activity
B6F84_RS10785	COG0535	radical SAM domain protein
B6F84_RS10795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6F84_RS10795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6F84_RS10805	COG0318	PFAM AMP-dependent synthetase and ligase
B6F84_RS10810	COG3118	belongs to the thioredoxin family
B6F84_RS10815	COG3842	ATPase activity
B6F84_RS10820	COG0174	glutamine synthetase
B6F84_RS10830	COG0302	gtp cyclohydrolase
B6F84_RS10835	COG0006	proline dipeptidase activity
B6F84_RS10840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6F84_RS10855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6F84_RS10920	COG0552	protein localization to endoplasmic reticulum
B6F84_RS10935	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B6F84_RS10940	COG0081	regulation of translation
B6F84_RS10955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6F84_RS10975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6F84_RS10995	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6F84_RS11000	COG0589	response to stress
B6F84_RS11010	COG0126	phosphoglycerate kinase activity
B6F84_RS11070	COG0719	Fe-S assembly protein
B6F84_RS11075	COG0396	ATPase activity
B6F84_RS11095	COG0509	glycine decarboxylation via glycine cleavage system
B6F84_RS11100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6F84_RS11105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6F84_RS11110	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B6F84_RS11125	COG0148	phosphopyruvate hydratase activity
B6F84_RS11145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6F84_RS11150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6F84_RS11165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B6F84_RS11205	COG0525	valine-tRNA ligase activity
B6F84_RS11210	COG0436	Aminotransferase
B6F84_RS11215	COG0134	indole-3-glycerol-phosphate synthase activity
B6F84_RS11220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B6F84_RS11220	COG0512	Glutamine amidotransferase of anthranilate synthase
B6F84_RS11225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6F84_RS11230	COG0135	phosphoribosylanthranilate isomerase activity
B6F84_RS11240	COG0159	tryptophan synthase activity
B6F84_RS11245	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
B6F84_RS11250	COG1254	Belongs to the acylphosphatase family
B6F84_RS11255	COG1260	myo-inositol-1-phosphate synthase
B6F84_RS11265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6F84_RS11265	COG0574	Belongs to the PEP-utilizing enzyme family
B6F84_RS11290	COG0460	homoserine dehydrogenase
B6F84_RS11290	COG0527	aspartate kinase activity
B6F84_RS11295	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B6F84_RS11300	COG0613	PHP domain protein
B6F84_RS11310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B6F84_RS11345	COG0459	protein refolding
B6F84_RS11405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6F84_RS11410	COG0252	asparaginase activity
B6F84_RS11440	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
B6F84_RS11490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B6F84_RS11490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6F84_RS11505	COG0154	amidase activity
B6F84_RS11510	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6F84_RS11515	COG1324	tolerance protein
B6F84_RS11525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B6F84_RS11550	COG1110	DNA topoisomerase II activity
B6F84_RS11560	COG0514	ATP-dependent DNA helicase (RecQ)
B6F84_RS11590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6F84_RS11595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6F84_RS11605	COG2084	Dehydrogenase
B6F84_RS11610	COG0438	transferase activity, transferring glycosyl groups
B6F84_RS11625	COG0528	UMP kinase activity
B6F84_RS11635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6F84_RS11645	COG0535	radical SAM domain protein
B6F84_RS11685	COG1131	(ABC) transporter
B6F84_RS11760	COG1215	transferase activity, transferring glycosyl groups
B6F84_RS11765	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6F84_RS11770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6F84_RS11780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6F84_RS11810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B6F84_RS11815	COG0004	ammonium transporteR
B6F84_RS11845	COG2409	Drug exporters of the RND superfamily
B6F84_RS11860	COG0589	response to stress
B6F84_RS11880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6F84_RS11885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6F84_RS11890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6F84_RS11925	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B6F84_RS11960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B6F84_RS12000	COG2149	membrane
B6F84_RS12010	COG1522	sequence-specific DNA binding
B6F84_RS12015	COG3386	PFAM SMP-30 Gluconolaconase
B6F84_RS12070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B6F84_RS12080	COG2814	Major facilitator Superfamily
B6F84_RS12085	COG0477	Major facilitator Superfamily
B6F84_RS12140	COG1335	isochorismatase
B6F84_RS12150	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B6F84_RS12220	COG1573	uracil-dna glycosylase
B6F84_RS12230	COG0823	Involved in the tonB-independent uptake of proteins
B6F84_RS12230	COG4946	Tricorn protease homolog
B6F84_RS12230	COG1506	peptidase
B6F84_RS12260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6F84_RS12285	COG1012	belongs to the aldehyde dehydrogenase family
B6F84_RS12290	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
B6F84_RS12300	COG1506	peptidase
B6F84_RS12300	COG4946	Tricorn protease homolog
B6F84_RS12300	COG0823	Involved in the tonB-independent uptake of proteins
B6F84_RS12310	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6F84_RS12320	COG1122	ATPase activity
B6F84_RS12330	COG3511	phospholipase C
B6F84_RS12360	COG0651	ATP synthesis coupled electron transport
B6F84_RS12365	COG0649	NAD binding
B6F84_RS12380	COG0650	Formate hydrogenlyase subunit 4
B6F84_RS12400	COG3842	ATPase activity
B6F84_RS12415	COG0730	response to heat
B6F84_RS12420	COG0813	purine-nucleoside phosphorylase activity
B6F84_RS12500	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B6F84_RS12520	COG0667	Aldo Keto reductase
B6F84_RS12565	COG0123	including yeast histone deacetylase and acetoin utilization protein
B6F84_RS12580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6F84_RS12590	COG2210	Belongs to the sulfur carrier protein TusA family
B6F84_RS12595	COG0425	Belongs to the sulfur carrier protein TusA family
B6F84_RS12610	COG0492	ferredoxin-NADP+ reductase activity
B6F84_RS12625	COG2048	Heterodisulfide reductase, subunit B
B6F84_RS12635	COG0509	glycine decarboxylation via glycine cleavage system
B6F84_RS12645	COG2814	Major facilitator Superfamily
B6F84_RS12650	COG0477	Major facilitator Superfamily
B6F84_RS12655	COG0095	Lipoate-protein ligase
B6F84_RS12660	COG0095	Lipoate-protein ligase
B6F84_RS12670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B6F84_RS12680	COG0450	alkyl hydroperoxide reductase
B6F84_RS12700	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B6F84_RS12705	COG0509	glycine decarboxylation via glycine cleavage system
B6F84_RS12710	COG0095	Lipoate-protein ligase
B6F84_RS12745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B6F84_RS12755	COG0644	oxidoreductase
B6F84_RS12765	COG1131	(ABC) transporter
B6F84_RS12825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6F84_RS12835	COG0475	glutathione-regulated potassium exporter activity
B6F84_RS12860	COG2814	Major facilitator Superfamily
B6F84_RS12915	COG2814	Major facilitator Superfamily
B6F84_RS12940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B6F84_RS12985	COG1401	restriction endodeoxyribonuclease activity
B6F84_RS12995	COG0456	acetyltransferase
B6F84_RS13020	COG2814	Major facilitator Superfamily
B6F84_RS13040	COG1131	(ABC) transporter
B6F84_RS13070	COG2217	Heavy metal translocating P-type atpase
B6F84_RS13075	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B6F84_RS13075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6F84_RS13115	COG0425	Belongs to the sulfur carrier protein TusA family
B6F84_RS13125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B6F84_RS13125	COG0425	Belongs to the sulfur carrier protein TusA family
B6F84_RS13170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6F84_RS13180	COG0805	protein transport
B6F84_RS13210	COG0277	FAD linked oxidase domain protein
B6F84_RS13230	COG1013	pyruvate-flavodoxin oxidoreductase activity
B6F84_RS13235	COG0674	pyruvate-flavodoxin oxidoreductase activity
B6F84_RS13255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B6F84_RS13265	COG0535	radical SAM domain protein
B6F84_RS13270	COG0535	radical SAM domain protein
B6F84_RS13330	COG1271	oxidase subunit
B6F84_RS13370	COG1373	ATPase (AAA superfamily
B6F84_RS13400	COG0531	amino acid
B6F84_RS13470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6F84_RS13555	COG0145	ligase activity
B6F84_RS13650	COG1091	dTDP-4-dehydrorhamnose reductase activity
B6F84_RS13695	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B6F84_RS13700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA