locus-tag	class	description
HS5_RS00030	COG0426	domain, Protein
HS5_RS00030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HS5_RS00070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HS5_RS00075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HS5_RS00085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HS5_RS00090	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HS5_RS00130	COG0004	ammonium transporteR
HS5_RS00165	COG0438	transferase activity, transferring glycosyl groups
HS5_RS00175	COG0589	response to stress
HS5_RS00200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HS5_RS00205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HS5_RS00210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HS5_RS00225	COG0045	succinate-CoA ligase (ADP-forming) activity
HS5_RS00245	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HS5_RS00250	COG1078	dGTPase activity
HS5_RS00290	COG0179	Fumarylacetoacetate (FAA) hydrolase
HS5_RS00320	COG3386	PFAM SMP-30 Gluconolaconase
HS5_RS00330	COG1695	Transcriptional regulator
HS5_RS00375	COG2814	Major facilitator Superfamily
HS5_RS00380	COG1335	isochorismatase
HS5_RS00470	COG3511	phospholipase C
HS5_RS00480	COG1122	ATPase activity
HS5_RS00525	COG0813	purine-nucleoside phosphorylase activity
HS5_RS00530	COG0730	response to heat
HS5_RS00535	COG0531	amino acid
HS5_RS00560	COG0535	radical SAM domain protein
HS5_RS00565	COG0535	radical SAM domain protein
HS5_RS00585	COG0644	oxidoreductase
HS5_RS00595	COG2086	electron transfer activity
HS5_RS00600	COG1960	acyl-CoA dehydrogenase activity
HS5_RS00605	COG0243	molybdopterin cofactor binding
HS5_RS00625	COG1175	transmembrane transport
HS5_RS00630	COG1177	transmembrane transport
HS5_RS00645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HS5_RS00690	COG2210	Belongs to the sulfur carrier protein TusA family
HS5_RS00695	COG0425	Belongs to the sulfur carrier protein TusA family
HS5_RS00710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS5_RS00725	COG2048	Heterodisulfide reductase, subunit B
HS5_RS00750	COG0509	glycine decarboxylation via glycine cleavage system
HS5_RS00755	COG0095	Lipoate-protein ligase
HS5_RS00775	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HS5_RS00795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HS5_RS00845	COG0437	4 iron, 4 sulfur cluster binding
HS5_RS00850	COG0243	molybdopterin cofactor binding
HS5_RS00885	COG0805	protein transport
HS5_RS00895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HS5_RS00925	COG2329	Antibiotic biosynthesis monooxygenase
HS5_RS00945	COG0477	Major facilitator Superfamily
HS5_RS01005	COG0589	response to stress
HS5_RS01010	COG2814	Major facilitator Superfamily
HS5_RS01015	COG1914	H( )-stimulated, divalent metal cation uptake system
HS5_RS01135	COG0028	Belongs to the TPP enzyme family
HS5_RS01150	COG2814	Major facilitator Superfamily
HS5_RS01155	COG1846	Transcriptional regulator
HS5_RS01180	COG1373	ATPase (AAA superfamily
HS5_RS01215	COG2217	Heavy metal translocating P-type atpase
HS5_RS01410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HS5_RS01425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HS5_RS01430	COG1216	Glycosyl transferase, family 2
HS5_RS01430	COG0463	Glycosyl transferase, family 2
HS5_RS01470	COG1215	transferase activity, transferring glycosyl groups
HS5_RS01550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HS5_RS01770	COG1312	Catalyzes the dehydration of D-mannonate
HS5_RS01780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HS5_RS01785	COG2264	protein methyltransferase activity
HS5_RS01800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HS5_RS01885	COG1113	amino acid transport
HS5_RS02055	COG0477	Major facilitator Superfamily
HS5_RS02065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_RS02080	COG2226	methyltransferase
HS5_RS02145	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HS5_RS02155	COG3383	formate dehydrogenase (NAD+) activity
HS5_RS02160	COG0515	serine threonine protein kinase
HS5_RS02160	COG2815	serine threonine protein kinase
HS5_RS02205	COG0515	serine threonine protein kinase
HS5_RS02205	COG2815	serine threonine protein kinase
HS5_RS02305	COG3391	amine dehydrogenase activity
HS5_RS02370	COG2151	metal-sulfur cluster biosynthetic enzyme
HS5_RS02375	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HS5_RS02455	COG1013	pyruvate-flavodoxin oxidoreductase activity
HS5_RS02460	COG0674	pyruvate-flavodoxin oxidoreductase activity
HS5_RS02465	COG1144	Oxidoreductase
HS5_RS02470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HS5_RS02475	COG0437	4 iron, 4 sulfur cluster binding
HS5_RS02490	COG1960	acyl-CoA dehydrogenase activity
HS5_RS02495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HS5_RS02500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HS5_RS02510	COG1960	acyl-CoA dehydrogenase activity
HS5_RS02520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HS5_RS02555	COG1024	Enoyl-CoA hydratase
HS5_RS02560	COG1250	3-hydroxyacyl-CoA dehydrogenase
HS5_RS02565	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HS5_RS02570	COG0655	NAD(P)H dehydrogenase (quinone) activity
HS5_RS02580	COG2079	MmgE PrpD family protein
HS5_RS02585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HS5_RS02590	COG0372	Belongs to the citrate synthase family
HS5_RS02615	COG2271	Major facilitator Superfamily
HS5_RS02620	COG2721	sulfolactate sulfo-lyase activity
HS5_RS02625	COG2721	sulfolactate sulfo-lyase activity
HS5_RS02635	COG1802	Transcriptional regulator
HS5_RS02720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HS5_RS02740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HS5_RS02800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_RS02825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS5_RS02885	COG0708	Exodeoxyribonuclease III
HS5_RS02910	COG0602	queuosine metabolic process
HS5_RS02955	COG1968	undecaprenyl-diphosphatase activity
HS5_RS02980	COG1489	DNA binding
HS5_RS03015	COG0656	L-ascorbic acid biosynthetic process
HS5_RS03100	COG3842	ATPase activity
HS5_RS03245	COG0531	amino acid
HS5_RS03260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HS5_RS03370	COG0515	serine threonine protein kinase
HS5_RS03370	COG2815	serine threonine protein kinase
HS5_RS03390	COG3387	PFAM Glycoside hydrolase 15-related
HS5_RS03395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HS5_RS03535	COG2271	Major facilitator Superfamily
HS5_RS03560	COG2329	Antibiotic biosynthesis monooxygenase
HS5_RS03615	COG1373	ATPase (AAA superfamily
HS5_RS03620	COG1013	pyruvate-flavodoxin oxidoreductase activity
HS5_RS03640	COG0531	amino acid
HS5_RS03645	COG2814	Major facilitator Superfamily
HS5_RS03650	COG0277	FAD linked oxidase domain protein
HS5_RS03755	COG0409	Hydrogenase expression formation protein
HS5_RS03765	COG0309	Hydrogenase expression formation protein (HypE)
HS5_RS03965	COG1131	(ABC) transporter
HS5_RS03995	COG0393	Putative heavy-metal-binding
HS5_RS04000	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HS5_RS04035	COG4139	cobalamin transport
HS5_RS04040	COG1119	ATPase activity
HS5_RS04060	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HS5_RS04110	COG3383	formate dehydrogenase (NAD+) activity
HS5_RS04145	COG1131	(ABC) transporter
HS5_RS04165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HS5_RS04175	COG2271	Major facilitator Superfamily
HS5_RS04255	COG2860	membrane
HS5_RS04290	COG1139	Iron-sulfur cluster binding protein
HS5_RS04310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HS5_RS04310	COG1042	CoA-binding domain protein
HS5_RS04310	COG0045	succinate-CoA ligase (ADP-forming) activity
HS5_RS04325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HS5_RS04330	COG0531	amino acid
HS5_RS04335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HS5_RS04340	COG1063	alcohol dehydrogenase
HS5_RS04350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HS5_RS04370	COG1129	ABC transporter
HS5_RS04390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HS5_RS04395	COG0066	3-isopropylmalate dehydratase activity
HS5_RS04435	COG0708	Exodeoxyribonuclease III
HS5_RS04450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HS5_RS04470	COG0157	Belongs to the NadC ModD family
HS5_RS04475	COG0519	Catalyzes the synthesis of GMP from XMP
HS5_RS04485	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HS5_RS04515	COG1515	deoxyribonuclease V activity
HS5_RS04520	COG1335	isochorismatase
HS5_RS04530	COG0450	alkyl hydroperoxide reductase
HS5_RS04545	COG0372	Belongs to the citrate synthase family
HS5_RS04565	COG4581	dead DEAH box helicase
HS5_RS04575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HS5_RS04585	COG0439	Biotin carboxylase
HS5_RS04615	COG0444	Belongs to the ABC transporter superfamily
HS5_RS04630	COG0601	transmembrane transport
HS5_RS04635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HS5_RS04705	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HS5_RS04710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HS5_RS04725	COG0189	ligase activity
HS5_RS04725	COG0569	domain protein
HS5_RS04730	COG1522	sequence-specific DNA binding
HS5_RS04745	COG1446	asparaginase
HS5_RS04780	COG0647	UMP catabolic process
HS5_RS04785	COG1053	succinate dehydrogenase
HS5_RS04795	COG2048	Heterodisulfide reductase, subunit B
HS5_RS04805	COG2304	oxidoreductase activity
HS5_RS04810	COG0714	Associated with various cellular activities
HS5_RS04825	COG0303	'Molybdopterin
HS5_RS04830	COG0083	homoserine kinase activity
HS5_RS04835	COG0626	cystathionine gamma-synthase activity
HS5_RS04875	COG0183	Belongs to the thiolase family
HS5_RS04880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HS5_RS04900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HS5_RS04915	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HS5_RS04920	COG1215	transferase activity, transferring glycosyl groups
HS5_RS04930	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HS5_RS04935	COG0351	phosphomethylpyrimidine kinase
HS5_RS04970	COG1131	(ABC) transporter
HS5_RS04995	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HS5_RS05000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HS5_RS05030	COG0720	synthase
HS5_RS05045	COG0492	ferredoxin-NADP+ reductase activity
HS5_RS05055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_RS05070	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HS5_RS05075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HS5_RS05075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HS5_RS05080	COG0346	lactoylglutathione lyase activity
HS5_RS05085	COG0071	Belongs to the small heat shock protein (HSP20) family
HS5_RS05110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HS5_RS05130	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HS5_RS05130	COG1648	precorrin-2 dehydrogenase activity
HS5_RS05170	COG1063	alcohol dehydrogenase
HS5_RS05175	COG0430	RNA-3'-phosphate cyclase activity
HS5_RS05190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS5_RS05200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HS5_RS05280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HS5_RS05290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HS5_RS05315	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HS5_RS05315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HS5_RS05320	COG0469	pyruvate kinase activity
HS5_RS05330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HS5_RS05350	COG0297	glycogen (starch) synthase activity
HS5_RS05380	COG1250	3-hydroxyacyl-CoA dehydrogenase
HS5_RS05385	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HS5_RS05740	COG4133	protoheme IX ABC transporter activity
HS5_RS05765	COG0644	oxidoreductase
HS5_RS05770	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HS5_RS05785	COG2368	4-hydroxyphenylacetate
HS5_RS05790	COG2271	Major facilitator Superfamily
HS5_RS05795	COG0179	Fumarylacetoacetate (FAA) hydrolase
HS5_RS05805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HS5_RS05810	COG0667	Aldo Keto reductase
HS5_RS05820	COG1131	(ABC) transporter
HS5_RS05840	COG1063	alcohol dehydrogenase
HS5_RS05860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HS5_RS05865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HS5_RS05865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HS5_RS05885	COG0488	(ABC) transporter
HS5_RS05920	COG0735	belongs to the Fur family
HS5_RS05940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HS5_RS05940	COG0517	IMP dehydrogenase activity
HS5_RS05940	COG0617	tRNA 3'-terminal CCA addition
HS5_RS05950	COG2062	phosphohistidine phosphatase, SixA
HS5_RS05965	COG3118	belongs to the thioredoxin family
HS5_RS05975	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HS5_RS06025	COG0492	ferredoxin-NADP+ reductase activity
HS5_RS06035	COG2814	Major facilitator Superfamily
HS5_RS06040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HS5_RS06060	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HS5_RS06070	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HS5_RS06090	COG0561	phosphatase activity
HS5_RS06100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HS5_RS06105	COG0537	adenosine 5'-monophosphoramidase activity
HS5_RS06120	COG3253	May function as heme-dependent peroxidase
HS5_RS06135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HS5_RS06140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HS5_RS06140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HS5_RS06160	COG2890	protein-(glutamine-N5) methyltransferase activity
HS5_RS06165	COG1695	Transcriptional regulator
HS5_RS06200	COG0538	isocitrate dehydrogenase activity
HS5_RS06215	COG2154	pterin-4-alpha-carbinolamine dehydratase
HS5_RS06240	COG0330	HflC and HflK could
HS5_RS06300	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HS5_RS06305	COG1028	Short-chain dehydrogenase reductase Sdr
HS5_RS06310	COG1331	Highly conserved protein containing a thioredoxin domain
HS5_RS06350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HS5_RS06355	COG0438	transferase activity, transferring glycosyl groups
HS5_RS06375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HS5_RS06380	COG1024	Enoyl-CoA hydratase
HS5_RS06435	COG1192	Involved in chromosome partitioning
HS5_RS06450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HS5_RS06465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HS5_RS06510	COG0438	transferase activity, transferring glycosyl groups
HS5_RS06515	COG0513	Belongs to the DEAD box helicase family
HS5_RS06525	COG1215	transferase activity, transferring glycosyl groups
HS5_RS06530	COG1215	transferase activity, transferring glycosyl groups
HS5_RS06570	COG0243	molybdopterin cofactor binding
HS5_RS06605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HS5_RS06605	COG0301	tRNA thio-modification
HS5_RS06630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_RS06635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS5_RS06645	COG1013	pyruvate-flavodoxin oxidoreductase activity
HS5_RS06685	COG4555	ABC transporter
HS5_RS06720	COG1131	(ABC) transporter
HS5_RS06735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HS5_RS06765	COG0477	Major facilitator Superfamily
HS5_RS06825	COG4946	Tricorn protease homolog
HS5_RS06825	COG1506	peptidase
HS5_RS06825	COG0823	Involved in the tonB-independent uptake of proteins
HS5_RS06835	COG1573	uracil-dna glycosylase
HS5_RS06865	COG0586	Pfam SNARE associated Golgi protein
HS5_RS06880	COG1028	Short-chain dehydrogenase reductase Sdr
HS5_RS06905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HS5_RS06905	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HS5_RS06920	COG0561	phosphatase activity
HS5_RS06925	COG2271	Major facilitator Superfamily
HS5_RS07060	COG0393	Putative heavy-metal-binding
HS5_RS07115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HS5_RS07120	COG0531	amino acid
HS5_RS07150	COG0601	transmembrane transport
HS5_RS07160	COG0444	Belongs to the ABC transporter superfamily
HS5_RS07165	COG4608	Belongs to the ABC transporter superfamily
HS5_RS07180	COG0650	Formate hydrogenlyase subunit 4
HS5_RS07190	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS5_RS07195	COG0649	NAD binding
HS5_RS07200	COG0651	ATP synthesis coupled electron transport
HS5_RS07205	COG0477	Major facilitator Superfamily
HS5_RS07235	COG0495	leucyl-tRNA aminoacylation
HS5_RS07260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HS5_RS07275	COG2814	Major facilitator Superfamily
HS5_RS07400	COG1846	Transcriptional regulator
HS5_RS07405	COG0477	Major facilitator Superfamily
HS5_RS07430	COG0375	protein maturation
HS5_RS07470	COG2239	Acts as a magnesium transporter
HS5_RS07510	COG0243	molybdopterin cofactor binding
HS5_RS07525	COG2226	methyltransferase
HS5_RS07530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HS5_RS07545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HS5_RS07630	COG4948	Mandelate Racemase Muconate Lactonizing
HS5_RS07640	COG3387	PFAM Glycoside hydrolase 15-related
HS5_RS07645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HS5_RS07685	COG2226	methyltransferase
HS5_RS07690	COG0531	amino acid
HS5_RS07695	COG1012	belongs to the aldehyde dehydrogenase family
HS5_RS07770	COG1175	transmembrane transport
HS5_RS07775	COG3833	ABC-type maltose transport systems, permease component
HS5_RS07780	COG3842	ATPase activity
HS5_RS07790	COG0459	protein refolding
HS5_RS07835	COG1305	Transglutaminase-like
HS5_RS07840	COG2308	Evidence 4 Homologs of previously reported genes of
HS5_RS07845	COG0674	pyruvate-flavodoxin oxidoreductase activity
HS5_RS07845	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HS5_RS07850	COG1013	pyruvate-flavodoxin oxidoreductase activity
HS5_RS07860	COG0450	alkyl hydroperoxide reductase
HS5_RS07865	COG0693	protein deglycase activity
HS5_RS07875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HS5_RS07875	COG0517	IMP dehydrogenase activity
HS5_RS07880	COG0372	Belongs to the citrate synthase family
HS5_RS07885	COG1960	acyl-CoA dehydrogenase activity
HS5_RS07895	COG0039	L-malate dehydrogenase activity
HS5_RS07940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HS5_RS07945	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HS5_RS07965	COG1401	restriction endodeoxyribonuclease activity
HS5_RS08030	COG0277	FAD linked oxidase domain protein
HS5_RS08045	COG0513	Belongs to the DEAD box helicase family
HS5_RS08090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HS5_RS08155	COG1203	CRISPR-associated helicase, Cas3
HS5_RS08285	COG1131	(ABC) transporter
HS5_RS08325	COG1131	(ABC) transporter
HS5_RS08330	COG1131	(ABC) transporter
HS5_RS08385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HS5_RS08420	COG1024	Enoyl-CoA hydratase
HS5_RS08425	COG1960	acyl-CoA dehydrogenase activity
HS5_RS08430	COG0318	PFAM AMP-dependent synthetase and ligase
HS5_RS08460	COG2301	Belongs to the HpcH HpaI aldolase family
HS5_RS08470	COG1832	CoA-binding protein
HS5_RS08475	COG0813	purine-nucleoside phosphorylase activity
HS5_RS08485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HS5_RS08490	COG1584	GPR1 FUN34 yaaH family protein
HS5_RS08495	COG3608	succinylglutamate desuccinylase aspartoacylase
HS5_RS08495	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HS5_RS08500	COG0281	malic enzyme
HS5_RS08525	COG0318	PFAM AMP-dependent synthetase and ligase
HS5_RS08530	COG1028	Short-chain dehydrogenase reductase Sdr
HS5_RS08540	COG2814	Major facilitator Superfamily
HS5_RS08570	COG0531	amino acid
HS5_RS08580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HS5_RS08585	COG1132	(ABC) transporter
HS5_RS08685	COG0519	Catalyzes the synthesis of GMP from XMP
HS5_RS08690	COG1473	amidohydrolase
HS5_RS08695	COG0402	S-adenosylhomocysteine deaminase activity
HS5_RS08705	COG0813	purine-nucleoside phosphorylase activity
HS5_RS08710	COG0831	urea catabolic process
HS5_RS08710	COG0832	Belongs to the urease beta subunit family
HS5_RS08715	COG0804	urea catabolic process
HS5_RS08720	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HS5_RS08730	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HS5_RS08740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HS5_RS08750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HS5_RS08755	COG0174	glutamine synthetase
HS5_RS08775	COG0402	S-adenosylhomocysteine deaminase activity
HS5_RS08790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HS5_RS08855	COG1953	Uracil, thiamine, allantoin
HS5_RS08875	COG1505	serine-type exopeptidase activity
HS5_RS08890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HS5_RS08905	COG2814	Major facilitator Superfamily
HS5_RS08910	COG0671	phosphoesterase, PA-phosphatase related
HS5_RS08930	COG0531	amino acid
HS5_RS08980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HS5_RS09000	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HS5_RS09010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HS5_RS09015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HS5_RS09025	COG0588	phosphoglycerate mutase activity
HS5_RS09035	COG2271	Major facilitator Superfamily
HS5_RS09040	COG0535	radical SAM domain protein
HS5_RS09045	COG1473	amidohydrolase
HS5_RS09055	COG0174	glutamine synthetase
HS5_RS09065	COG1011	Hydrolase
HS5_RS09075	COG0477	Major facilitator Superfamily
HS5_RS09135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HS5_RS09160	COG1960	acyl-CoA dehydrogenase activity
HS5_RS09165	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HS5_RS09200	COG2222	sugar isomerase
HS5_RS09210	COG1051	belongs to the nudix hydrolase family
HS5_RS09220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HS5_RS09230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HS5_RS09235	COG1028	Short-chain dehydrogenase reductase Sdr
HS5_RS09240	COG1573	uracil-dna glycosylase
HS5_RS09270	COG0475	glutathione-regulated potassium exporter activity
HS5_RS09275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HS5_RS09295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HS5_RS09330	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HS5_RS09335	COG1881	PFAM PEBP family protein
HS5_RS09345	COG2255	four-way junction helicase activity
HS5_RS09350	COG0315	cyclic pyranopterin monophosphate synthase activity
HS5_RS09405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HS5_RS09430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HS5_RS09435	COG1444	tRNA N-acetyltransferase activity
HS5_RS09455	COG0589	response to stress
HS5_RS09460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HS5_RS09465	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HS5_RS09465	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HS5_RS09470	COG0009	L-threonylcarbamoyladenylate synthase
HS5_RS09475	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS5_RS09480	COG2379	hydroxypyruvate reductase
HS5_RS09490	COG1321	iron dependent repressor
HS5_RS09510	COG2226	methyltransferase
HS5_RS09525	COG0303	'Molybdopterin
HS5_RS09530	COG0746	molybdenum cofactor guanylyltransferase activity
HS5_RS09545	COG0402	S-adenosylhomocysteine deaminase activity
HS5_RS09575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HS5_RS09620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HS5_RS09635	COG1201	RNA secondary structure unwinding
HS5_RS09640	COG0617	tRNA 3'-terminal CCA addition
HS5_RS09640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HS5_RS09640	COG3620	sequence-specific DNA binding
HS5_RS09665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HS5_RS09670	COG1058	Belongs to the CinA family
HS5_RS09670	COG1546	Belongs to the CinA family
HS5_RS09690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HS5_RS09695	COG0024	Methionine aminopeptidase
HS5_RS09720	COG0561	phosphatase activity
HS5_RS09725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HS5_RS09745	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HS5_RS09750	COG1047	Peptidyl-prolyl cis-trans
HS5_RS09755	COG0371	Dehydrogenase
HS5_RS09760	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HS5_RS09775	COG0028	Belongs to the TPP enzyme family
HS5_RS09795	COG0017	Asparaginyl-tRNA synthetase
HS5_RS09800	COG0585	pseudouridine synthase activity
HS5_RS09820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_RS09830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HS5_RS09835	COG1648	precorrin-2 dehydrogenase activity
HS5_RS09835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HS5_RS09840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HS5_RS09845	COG0113	porphobilinogen synthase activity
HS5_RS09850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HS5_RS09855	COG0181	hydroxymethylbilane synthase activity
HS5_RS09880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HS5_RS09890	COG1793	dna ligase
HS5_RS09895	COG0717	Belongs to the dCTP deaminase family
HS5_RS09910	COG2078	PFAM AMMECR1 domain protein
HS5_RS09940	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
HS5_RS09955	COG0504	CTP synthase activity
HS5_RS09960	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HS5_RS09980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HS5_RS10005	COG0509	glycine decarboxylation via glycine cleavage system
HS5_RS10015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HS5_RS10020	COG0095	Lipoate-protein ligase
HS5_RS10065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HS5_RS10070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HS5_RS10095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HS5_RS10100	COG0142	geranyltranstransferase activity
HS5_RS10105	COG1304	FMN binding
HS5_RS10110	COG0528	UMP kinase activity
HS5_RS10120	COG1355	regulation of microtubule-based process
HS5_RS10125	COG0052	Belongs to the universal ribosomal protein uS2 family
HS5_RS10135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HS5_RS10140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HS5_RS10145	COG0200	Binds to the 23S rRNA
HS5_RS10155	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HS5_RS10160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HS5_RS10165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HS5_RS10185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HS5_RS10195	COG0417	DNA replication proofreading
HS5_RS10225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HS5_RS10230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HS5_RS10260	COG0023	Translation Initiation Factor
HS5_RS10275	COG0423	glycine-tRNA ligase activity
HS5_RS10305	COG0163	prenyltransferase activity
HS5_RS10310	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HS5_RS10325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HS5_RS10335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HS5_RS10340	COG0667	Aldo Keto reductase
HS5_RS10385	COG1110	DNA topoisomerase II activity
HS5_RS10390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_RS10395	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HS5_RS10410	COG0557	exoribonuclease II activity
HS5_RS10445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HS5_RS10460	COG1797	cobyrinic acid a,c-diamide synthase activity
HS5_RS10475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HS5_RS10475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HS5_RS10485	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HS5_RS10515	COG1201	RNA secondary structure unwinding
HS5_RS10525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HS5_RS10535	COG2813	Specifically methylates the guanine in position
HS5_RS10555	COG0051	transcription antitermination factor activity, RNA binding
HS5_RS10560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HS5_RS10565	COG0049	tRNA binding
HS5_RS10590	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HS5_RS10595	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HS5_RS10600	COG0085	RNA polymerase activity
HS5_RS10610	COG0281	malic enzyme
HS5_RS10615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HS5_RS10620	COG0105	UTP biosynthetic process
HS5_RS10635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HS5_RS10645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HS5_RS10650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HS5_RS10660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HS5_RS10665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HS5_RS10680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HS5_RS10695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HS5_RS10700	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HS5_RS10705	COG1522	sequence-specific DNA binding
HS5_RS10710	COG0077	Prephenate dehydratase
HS5_RS10710	COG1605	Chorismate mutase
HS5_RS10715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HS5_RS10735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HS5_RS10735	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HS5_RS10750	COG1051	belongs to the nudix hydrolase family
HS5_RS10750	COG1056	cytidyltransferase-related domain
HS5_RS10755	COG1607	acyl-coa hydrolase
HS5_RS10805	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HS5_RS10825	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HS5_RS10840	COG1121	(ABC) transporter
HS5_RS10845	COG1980	fructose-bisphosphate aldolase activity
HS5_RS10880	COG0124	histidyl-tRNA synthetase
HS5_RS10900	COG0343	queuine tRNA-ribosyltransferase activity
HS5_RS10915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_RS10925	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HS5_RS10965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HS5_RS11000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HS5_RS11005	COG2264	protein methyltransferase activity
HS5_RS11010	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HS5_RS11025	COG0012	GTP binding
HS5_RS11065	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HS5_RS11070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HS5_RS11090	COG0322	excinuclease ABC activity
HS5_RS11095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HS5_RS11100	COG0546	phosphoglycolate phosphatase activity
HS5_RS11115	COG0473	3-isopropylmalate dehydrogenase activity
HS5_RS11120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HS5_RS11130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HS5_RS11145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HS5_RS11150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HS5_RS11155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HS5_RS11160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HS5_RS11165	COG0255	Belongs to the universal ribosomal protein uL29 family
HS5_RS11180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HS5_RS11185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HS5_RS11195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HS5_RS11205	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HS5_RS11210	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HS5_RS11230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HS5_RS11240	COG0200	Binds to the 23S rRNA
HS5_RS11245	COG0201	protein transport
HS5_RS11260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HS5_RS11325	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HS5_RS11340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HS5_RS11345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HS5_RS11360	COG0189	ligase activity
HS5_RS11365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HS5_RS11370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HS5_RS11375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HS5_RS11395	COG0114	fumarate hydratase activity
HS5_RS11410	COG0517	IMP dehydrogenase activity
HS5_RS11410	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HS5_RS11440	COG0149	triose-phosphate isomerase activity
HS5_RS11455	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HS5_RS11460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HS5_RS11490	COG0515	serine threonine protein kinase
HS5_RS11490	COG2815	serine threonine protein kinase
HS5_RS11500	COG0251	oxidation-reduction process
HS5_RS11515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HS5_RS11515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HS5_RS11530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HS5_RS11540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HS5_RS11565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HS5_RS11590	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HS5_RS11620	COG0543	2 iron, 2 sulfur cluster binding
HS5_RS11620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HS5_RS11635	COG0668	transmembrane transport
HS5_RS11665	COG1720	tRNA m6t6A37 methyltransferase activity
HS5_RS11690	COG0037	tRNA processing
HS5_RS11745	COG0823	Involved in the tonB-independent uptake of proteins
HS5_RS11745	COG1506	peptidase
HS5_RS11745	COG4946	Tricorn protease homolog
HS5_RS11765	COG2409	Drug exporters of the RND superfamily
HS5_RS11800	COG0489	protein tyrosine kinase activity
HS5_RS11850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HS5_RS11915	COG1024	Enoyl-CoA hydratase
HS5_RS11920	COG0183	Belongs to the thiolase family
HS5_RS11970	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HS5_RS11975	COG3830	Belongs to the UPF0237 family
HS5_RS11980	COG2848	UPF0210 protein
HS5_RS11990	COG0438	transferase activity, transferring glycosyl groups
HS5_RS12035	COG1584	GPR1 FUN34 yaaH family protein
HS5_RS12040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HS5_RS12055	COG2814	Major facilitator Superfamily
HS5_RS12135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HS5_RS12145	COG1131	(ABC) transporter
HS5_RS12155	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HS5_RS12190	COG0501	Belongs to the peptidase M48B family
HS5_RS12215	COG0477	Major facilitator Superfamily
HS5_RS12250	COG1592	Rubrerythrin
HS5_RS12270	COG0450	alkyl hydroperoxide reductase
HS5_RS12280	COG1215	transferase activity, transferring glycosyl groups
HS5_RS12290	COG0352	thiamine-phosphate diphosphorylase activity
HS5_RS12290	COG0351	phosphomethylpyrimidine kinase
HS5_RS12295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HS5_RS12300	COG0123	including yeast histone deacetylase and acetoin utilization protein
HS5_RS12320	COG1234	tRNA 3'-trailer cleavage
HS5_RS12325	COG0006	proline dipeptidase activity
HS5_RS12350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HS5_RS12360	COG0501	Belongs to the peptidase M48B family
HS5_RS12365	COG1063	alcohol dehydrogenase
HS5_RS12385	COG0519	Catalyzes the synthesis of GMP from XMP
HS5_RS12390	COG0501	Belongs to the peptidase M48B family
HS5_RS12410	COG1830	Aldolase
HS5_RS12430	COG0405	Gamma-glutamyltransferase
HS5_RS12445	COG1444	tRNA N-acetyltransferase activity
HS5_RS12465	COG0589	response to stress
HS5_RS12480	COG0864	Transcriptional regulator
HS5_RS12490	COG0460	homoserine dehydrogenase
HS5_RS12495	COG1612	heme a metabolic process
HS5_RS12495	COG0109	protoheme IX farnesyltransferase activity
HS5_RS12505	COG1024	Enoyl-CoA hydratase
HS5_RS12545	COG1250	3-hydroxyacyl-CoA dehydrogenase
HS5_RS12555	COG0189	ligase activity
HS5_RS12560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HS5_RS12570	COG0165	Argininosuccinate lyase
HS5_RS12575	COG0137	argininosuccinate synthase activity
HS5_RS12590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HS5_RS12595	COG0151	Belongs to the GarS family
HS5_RS12600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HS5_RS12605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HS5_RS12610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HS5_RS12615	COG0047	phosphoribosylformylglycinamidine synthase activity
HS5_RS12625	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HS5_RS12630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HS5_RS12630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HS5_RS12635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HS5_RS12680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HS5_RS12685	COG0540	Belongs to the ATCase OTCase family
HS5_RS12690	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HS5_RS12705	COG0167	dihydroorotate dehydrogenase activity
HS5_RS12720	COG2095	MarC family integral membrane protein
HS5_RS12725	COG1522	sequence-specific DNA binding
HS5_RS12740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HS5_RS12745	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HS5_RS12750	COG2151	metal-sulfur cluster biosynthetic enzyme
HS5_RS12760	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HS5_RS12770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HS5_RS12775	COG0107	imidazoleglycerol-phosphate synthase activity
HS5_RS12780	COG0131	Imidazoleglycerol-phosphate dehydratase
HS5_RS12785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HS5_RS12790	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HS5_RS12795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HS5_RS12805	COG0495	leucyl-tRNA aminoacylation
HS5_RS12810	COG2096	Adenosyltransferase
HS5_RS12815	COG0037	tRNA processing
HS5_RS12825	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HS5_RS12840	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HS5_RS12850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HS5_RS12855	COG0546	phosphoglycolate phosphatase activity
HS5_RS12860	COG0028	Belongs to the TPP enzyme family
HS5_RS12885	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HS5_RS12890	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HS5_RS12900	COG0442	prolyl-tRNA aminoacylation
HS5_RS12925	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HS5_RS12945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HS5_RS12965	COG2264	protein methyltransferase activity
HS5_RS12975	COG0417	DNA replication proofreading
HS5_RS12990	COG1260	myo-inositol-1-phosphate synthase
HS5_RS12995	COG1007	ATP synthesis coupled electron transport
HS5_RS13000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HS5_RS13005	COG0713	ATP synthesis coupled electron transport
HS5_RS13015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS5_RS13020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HS5_RS13025	COG0649	NAD binding
HS5_RS13030	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HS5_RS13040	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HS5_RS13060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HS5_RS13115	COG0083	homoserine kinase activity
HS5_RS13120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HS5_RS13125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HS5_RS13130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HS5_RS13135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HS5_RS13140	COG0077	Prephenate dehydratase
HS5_RS13140	COG1605	Chorismate mutase
HS5_RS13145	COG3958	Transketolase
HS5_RS13150	COG3959	Transketolase, thiamine diphosphate binding domain
HS5_RS13210	COG0067	glutamate synthase
HS5_RS13215	COG0069	glutamate synthase activity
HS5_RS13240	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HS5_RS13300	COG1185	polyribonucleotide nucleotidyltransferase activity
HS5_RS13320	COG0477	Major facilitator Superfamily
HS5_RS13365	COG0725	ABC transporter, periplasmic molybdate-binding protein
HS5_RS13370	COG0300	oxidoreductase activity
HS5_RS13375	COG0084	hydrolase, TatD family'
HS5_RS13405	COG0535	radical SAM domain protein
HS5_RS13410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HS5_RS13415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HS5_RS13415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HS5_RS13425	COG0318	PFAM AMP-dependent synthetase and ligase
HS5_RS13430	COG3118	belongs to the thioredoxin family
HS5_RS13435	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HS5_RS13440	COG0174	glutamine synthetase
HS5_RS13450	COG0302	gtp cyclohydrolase
HS5_RS13460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HS5_RS13540	COG0552	protein localization to endoplasmic reticulum
HS5_RS13555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HS5_RS13575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HS5_RS13590	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HS5_RS13595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HS5_RS13615	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HS5_RS13630	COG0126	phosphoglycerate kinase activity
HS5_RS13660	COG0477	Major facilitator Superfamily
HS5_RS13660	COG2814	Major facilitator Superfamily
HS5_RS13760	COG0396	ATPase activity
HS5_RS13780	COG0509	glycine decarboxylation via glycine cleavage system
HS5_RS13785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HS5_RS13790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HS5_RS13795	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HS5_RS13830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HS5_RS13835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HS5_RS13850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HS5_RS13890	COG0525	valine-tRNA ligase activity
HS5_RS13895	COG0436	Aminotransferase
HS5_RS13900	COG0134	indole-3-glycerol-phosphate synthase activity
HS5_RS13905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HS5_RS13905	COG0512	Glutamine amidotransferase of anthranilate synthase
HS5_RS13910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HS5_RS13915	COG0135	phosphoribosylanthranilate isomerase activity
HS5_RS13925	COG0159	tryptophan synthase activity
HS5_RS13930	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HS5_RS13935	COG1254	Belongs to the acylphosphatase family
HS5_RS13945	COG0574	Belongs to the PEP-utilizing enzyme family
HS5_RS13945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HS5_RS13960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HS5_RS13970	COG0527	aspartate kinase activity
HS5_RS13975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HS5_RS13990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HS5_RS14025	COG0459	protein refolding
HS5_RS14050	COG0018	arginyl-trna synthetase
HS5_RS14075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HS5_RS14090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HS5_RS14095	COG0252	asparaginase activity
HS5_RS14125	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
HS5_RS14175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HS5_RS14175	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HS5_RS14190	COG0154	amidase activity
HS5_RS14200	COG1324	tolerance protein
HS5_RS14210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HS5_RS14235	COG1110	DNA topoisomerase II activity
HS5_RS14245	COG0514	ATP-dependent DNA helicase (RecQ)
HS5_RS14280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HS5_RS14285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HS5_RS14295	COG2084	Dehydrogenase
HS5_RS14315	COG0528	UMP kinase activity
HS5_RS14325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HS5_RS14435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HS5_RS14460	COG1312	Catalyzes the dehydration of D-mannonate
HS5_RS14505	COG0656	L-ascorbic acid biosynthetic process