locus-tag	class	description
DFR86_RS00005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DFR86_RS00090	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DFR86_RS00210	COG0584	glycerophosphoryl diester phosphodiesterase
DFR86_RS00220	COG1373	ATPase (AAA superfamily
DFR86_RS00225	COG4555	ABC transporter
DFR86_RS00245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DFR86_RS00320	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DFR86_RS00325	COG0437	4 iron, 4 sulfur cluster binding
DFR86_RS00360	COG1175	transmembrane transport
DFR86_RS00365	COG3833	ABC-type maltose transport systems, permease component
DFR86_RS00370	COG3842	ATPase activity
DFR86_RS00395	COG0515	serine threonine protein kinase
DFR86_RS00395	COG2815	serine threonine protein kinase
DFR86_RS00410	COG1201	RNA secondary structure unwinding
DFR86_RS00430	COG0433	COG0433 Predicted ATPase
DFR86_RS00465	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DFR86_RS00500	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS00505	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS00510	COG1144	Oxidoreductase
DFR86_RS00520	COG1960	acyl-CoA dehydrogenase activity
DFR86_RS00535	COG0437	4 iron, 4 sulfur cluster binding
DFR86_RS00565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS00570	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR86_RS00585	COG0183	Belongs to the thiolase family
DFR86_RS00590	COG1024	Enoyl-CoA hydratase
DFR86_RS00610	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR86_RS00670	COG1215	transferase activity, transferring glycosyl groups
DFR86_RS00725	COG1373	ATPase (AAA superfamily
DFR86_RS00760	COG1177	transmembrane transport
DFR86_RS00770	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DFR86_RS00795	COG1373	ATPase (AAA superfamily
DFR86_RS00880	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DFR86_RS00885	COG1091	dTDP-4-dehydrorhamnose reductase activity
DFR86_RS00895	COG2192	nodulation
DFR86_RS00900	COG1215	transferase activity, transferring glycosyl groups
DFR86_RS00925	COG1216	Glycosyl transferase, family 2
DFR86_RS00930	COG1216	Glycosyl transferase, family 2
DFR86_RS00930	COG1442	glycosyl transferase family 8
DFR86_RS00935	COG1216	Glycosyl transferase, family 2
DFR86_RS00975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DFR86_RS01005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DFR86_RS01030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS01055	COG1960	acyl-CoA dehydrogenase activity
DFR86_RS01060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS01070	COG0601	transmembrane transport
DFR86_RS01075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR86_RS01080	COG0444	Belongs to the ABC transporter superfamily
DFR86_RS01085	COG4608	Belongs to the ABC transporter superfamily
DFR86_RS01100	COG0519	Catalyzes the synthesis of GMP from XMP
DFR86_RS01105	COG1832	CoA-binding protein
DFR86_RS01145	COG1473	amidohydrolase
DFR86_RS01165	COG0531	amino acid
DFR86_RS01170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS01225	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DFR86_RS01240	COG2814	Major facilitator Superfamily
DFR86_RS01245	COG0243	molybdopterin cofactor binding
DFR86_RS01250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS01255	COG2084	Dehydrogenase
DFR86_RS01265	COG0247	lactate metabolic process
DFR86_RS01270	COG1592	Rubrerythrin
DFR86_RS01275	COG0028	Belongs to the TPP enzyme family
DFR86_RS01280	COG0446	pyridine nucleotide-disulphide oxidoreductase
DFR86_RS01290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DFR86_RS01295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS01330	COG0039	L-malate dehydrogenase activity
DFR86_RS01335	COG2079	MmgE PrpD family protein
DFR86_RS01340	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DFR86_RS01345	COG0517	IMP dehydrogenase activity
DFR86_RS01345	COG0516	GMP reductase activity
DFR86_RS01350	COG0372	Belongs to the citrate synthase family
DFR86_RS01400	COG0525	valine-tRNA ligase activity
DFR86_RS01430	COG1028	Short-chain dehydrogenase reductase Sdr
DFR86_RS01450	COG2271	Major facilitator Superfamily
DFR86_RS01480	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DFR86_RS01485	COG0114	fumarate hydratase activity
DFR86_RS01490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR86_RS01580	COG2860	membrane
DFR86_RS01590	COG1131	(ABC) transporter
DFR86_RS01605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DFR86_RS01605	COG0045	succinate-CoA ligase (ADP-forming) activity
DFR86_RS01605	COG1042	CoA-binding domain protein
DFR86_RS01615	COG0531	amino acid
DFR86_RS01620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS01625	COG1063	alcohol dehydrogenase
DFR86_RS01665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DFR86_RS01670	COG0066	3-isopropylmalate dehydratase activity
DFR86_RS01675	COG0778	Nitroreductase
DFR86_RS01705	COG0157	Belongs to the NadC ModD family
DFR86_RS01710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DFR86_RS01710	COG0519	Catalyzes the synthesis of GMP from XMP
DFR86_RS01720	COG0351	phosphomethylpyrimidine kinase
DFR86_RS01720	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DFR86_RS01720	COG0352	thiamine-phosphate diphosphorylase activity
DFR86_RS01725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DFR86_RS01745	COG0708	Exodeoxyribonuclease III
DFR86_RS01755	COG5599	Phosphatase
DFR86_RS01760	COG1515	deoxyribonuclease V activity
DFR86_RS01775	COG0450	alkyl hydroperoxide reductase
DFR86_RS01790	COG0372	Belongs to the citrate synthase family
DFR86_RS01810	COG4581	dead DEAH box helicase
DFR86_RS01815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DFR86_RS01825	COG0439	Biotin carboxylase
DFR86_RS01835	COG1116	anion transmembrane transporter activity
DFR86_RS01845	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DFR86_RS01875	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS01885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR86_RS01895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS01915	COG0301	tRNA thio-modification
DFR86_RS01915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DFR86_RS01930	COG0477	Major facilitator Superfamily
DFR86_RS01945	COG0671	phosphoesterase, PA-phosphatase related
DFR86_RS01950	COG2226	methyltransferase
DFR86_RS01960	COG0243	molybdopterin cofactor binding
DFR86_RS02000	COG0513	Belongs to the DEAD box helicase family
DFR86_RS02045	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DFR86_RS02050	COG0123	including yeast histone deacetylase and acetoin utilization protein
DFR86_RS02060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DFR86_RS02080	COG1192	Involved in chromosome partitioning
DFR86_RS02095	COG1695	Transcriptional regulator
DFR86_RS02115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DFR86_RS02125	COG1131	(ABC) transporter
DFR86_RS02135	COG1024	Enoyl-CoA hydratase
DFR86_RS02140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS02160	COG0438	transferase activity, transferring glycosyl groups
DFR86_RS02165	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR86_RS02205	COG1331	Highly conserved protein containing a thioredoxin domain
DFR86_RS02210	COG1028	Short-chain dehydrogenase reductase Sdr
DFR86_RS02215	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DFR86_RS02275	COG0330	HflC and HflK could
DFR86_RS02300	COG2154	pterin-4-alpha-carbinolamine dehydratase
DFR86_RS02315	COG0538	isocitrate dehydrogenase activity
DFR86_RS02370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DFR86_RS02370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DFR86_RS02375	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DFR86_RS02405	COG3253	May function as heme-dependent peroxidase
DFR86_RS02420	COG0537	adenosine 5'-monophosphoramidase activity
DFR86_RS02425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DFR86_RS02435	COG0154	amidase activity
DFR86_RS02445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR86_RS02450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DFR86_RS02450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DFR86_RS02470	COG0497	DNA recombination
DFR86_RS02505	COG0735	belongs to the Fur family
DFR86_RS02525	COG0516	GMP reductase activity
DFR86_RS02525	COG0517	IMP dehydrogenase activity
DFR86_RS02560	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DFR86_RS02615	COG0492	ferredoxin-NADP+ reductase activity
DFR86_RS02625	COG2814	Major facilitator Superfamily
DFR86_RS02630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DFR86_RS02650	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DFR86_RS02660	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DFR86_RS02675	COG0561	phosphatase activity
DFR86_RS02720	COG0517	IMP dehydrogenase activity
DFR86_RS02720	COG0516	GMP reductase activity
DFR86_RS02725	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DFR86_RS02730	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR86_RS02750	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DFR86_RS02760	COG0297	glycogen (starch) synthase activity
DFR86_RS02810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR86_RS02815	COG0546	phosphoglycolate phosphatase activity
DFR86_RS02825	COG1061	Type III restriction enzyme res subunit
DFR86_RS02895	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DFR86_RS02900	COG1051	belongs to the nudix hydrolase family
DFR86_RS02905	COG2255	four-way junction helicase activity
DFR86_RS02910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DFR86_RS02915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DFR86_RS02925	COG0430	RNA-3'-phosphate cyclase activity
DFR86_RS02935	COG0174	glutamine synthetase
DFR86_RS02970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DFR86_RS02970	COG1648	precorrin-2 dehydrogenase activity
DFR86_RS02990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DFR86_RS03015	COG0071	Belongs to the small heat shock protein (HSP20) family
DFR86_RS03020	COG0346	lactoylglutathione lyase activity
DFR86_RS03025	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR86_RS03025	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR86_RS03030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DFR86_RS03045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS03055	COG0492	ferredoxin-NADP+ reductase activity
DFR86_RS03070	COG0720	synthase
DFR86_RS03100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFR86_RS03105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DFR86_RS03130	COG4555	ABC transporter
DFR86_RS03140	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DFR86_RS03170	COG0351	phosphomethylpyrimidine kinase
DFR86_RS03175	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DFR86_RS03225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR86_RS03230	COG0183	Belongs to the thiolase family
DFR86_RS03270	COG0626	cystathionine gamma-synthase activity
DFR86_RS03275	COG0083	homoserine kinase activity
DFR86_RS03295	COG0714	Associated with various cellular activities
DFR86_RS03300	COG2304	oxidoreductase activity
DFR86_RS03325	COG0647	UMP catabolic process
DFR86_RS03340	COG0644	oxidoreductase
DFR86_RS03355	COG1446	asparaginase
DFR86_RS03370	COG1522	sequence-specific DNA binding
DFR86_RS03375	COG0569	domain protein
DFR86_RS03375	COG0189	ligase activity
DFR86_RS03380	COG0142	geranyltranstransferase activity
DFR86_RS03390	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DFR86_RS03395	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DFR86_RS03425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DFR86_RS03460	COG4555	ABC transporter
DFR86_RS03515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DFR86_RS03555	COG0477	Major facilitator Superfamily
DFR86_RS03560	COG2814	Major facilitator Superfamily
DFR86_RS03565	COG0750	zinc metalloprotease
DFR86_RS03600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR86_RS03605	COG0477	Major facilitator Superfamily
DFR86_RS03615	COG2723	6-phospho-beta-galactosidase activity
DFR86_RS03620	COG3387	PFAM Glycoside hydrolase 15-related
DFR86_RS03625	COG2308	Evidence 4 Homologs of previously reported genes of
DFR86_RS03640	COG0640	Transcriptional regulator
DFR86_RS03650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR86_RS03660	COG4139	cobalamin transport
DFR86_RS03665	COG1121	(ABC) transporter
DFR86_RS03685	COG2814	Major facilitator Superfamily
DFR86_RS03695	COG0730	response to heat
DFR86_RS03705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DFR86_RS03740	COG1131	(ABC) transporter
DFR86_RS03765	COG0589	response to stress
DFR86_RS03780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DFR86_RS03790	COG0657	acetylesterase activity
DFR86_RS03795	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS03795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DFR86_RS03800	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS03810	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DFR86_RS03815	COG1733	regulation of RNA biosynthetic process
DFR86_RS03830	COG1131	(ABC) transporter
DFR86_RS03845	COG0531	amino acid
DFR86_RS03860	COG3383	formate dehydrogenase (NAD+) activity
DFR86_RS03870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DFR86_RS03940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS03960	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DFR86_RS03965	COG0375	protein maturation
DFR86_RS03995	COG0309	Hydrogenase expression formation protein (HypE)
DFR86_RS04005	COG0409	Hydrogenase expression formation protein
DFR86_RS04045	COG2226	methyltransferase
DFR86_RS04070	COG0243	molybdopterin cofactor binding
DFR86_RS04150	COG1522	sequence-specific DNA binding
DFR86_RS04160	COG0477	Major facilitator Superfamily
DFR86_RS04165	COG0277	FAD linked oxidase domain protein
DFR86_RS04200	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DFR86_RS04210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR86_RS04215	COG0402	S-adenosylhomocysteine deaminase activity
DFR86_RS04225	COG1953	Uracil, thiamine, allantoin
DFR86_RS04265	COG2080	2 iron, 2 sulfur cluster binding
DFR86_RS04265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DFR86_RS04270	COG0402	S-adenosylhomocysteine deaminase activity
DFR86_RS04275	COG2235	arginine
DFR86_RS04285	COG0531	amino acid
DFR86_RS04290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR86_RS04320	COG0402	S-adenosylhomocysteine deaminase activity
DFR86_RS04330	COG0832	Belongs to the urease beta subunit family
DFR86_RS04330	COG0831	urea catabolic process
DFR86_RS04345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DFR86_RS04375	COG4948	Mandelate Racemase Muconate Lactonizing
DFR86_RS04390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS04420	COG4948	Mandelate Racemase Muconate Lactonizing
DFR86_RS04430	COG1132	(ABC) transporter
DFR86_RS04445	COG4608	Belongs to the ABC transporter superfamily
DFR86_RS04450	COG0444	Belongs to the ABC transporter superfamily
DFR86_RS04455	COG0601	transmembrane transport
DFR86_RS04465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR86_RS04485	COG0477	Major facilitator Superfamily
DFR86_RS04515	COG0601	transmembrane transport
DFR86_RS04520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR86_RS04530	COG4608	Belongs to the ABC transporter superfamily
DFR86_RS04545	COG0281	malic enzyme
DFR86_RS04560	COG0531	amino acid
DFR86_RS04565	COG0469	pyruvate kinase activity
DFR86_RS04570	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DFR86_RS04570	COG3608	succinylglutamate desuccinylase aspartoacylase
DFR86_RS04590	COG2814	Major facilitator Superfamily
DFR86_RS04635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DFR86_RS04635	COG0574	Belongs to the PEP-utilizing enzyme family
DFR86_RS04640	COG1584	GPR1 FUN34 yaaH family protein
DFR86_RS04645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR86_RS04660	COG2368	4-hydroxyphenylacetate
DFR86_RS04670	COG0477	Major facilitator Superfamily
DFR86_RS04680	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DFR86_RS04685	COG0179	Fumarylacetoacetate (FAA) hydrolase
DFR86_RS04690	COG3384	dioxygenase
DFR86_RS04695	COG2226	methyltransferase
DFR86_RS04710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS04715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS04775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR86_RS04785	COG1139	Iron-sulfur cluster binding protein
DFR86_RS04795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DFR86_RS04810	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DFR86_RS04820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DFR86_RS04825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DFR86_RS04825	COG0731	radical SAM domain protein
DFR86_RS04835	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR86_RS04850	COG1505	serine-type exopeptidase activity
DFR86_RS04860	COG0277	FAD linked oxidase domain protein
DFR86_RS04870	COG2814	Major facilitator Superfamily
DFR86_RS04895	COG3387	PFAM Glycoside hydrolase 15-related
DFR86_RS04950	COG1741	Belongs to the pirin family
DFR86_RS04970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DFR86_RS04985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR86_RS04990	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR86_RS05000	COG2062	phosphohistidine phosphatase, SixA
DFR86_RS05035	COG0477	Major facilitator Superfamily
DFR86_RS05055	COG2271	Major facilitator Superfamily
DFR86_RS05110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFR86_RS05120	COG0109	protoheme IX farnesyltransferase activity
DFR86_RS05135	COG1960	acyl-CoA dehydrogenase activity
DFR86_RS05140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DFR86_RS05150	COG1607	acyl-coa hydrolase
DFR86_RS05170	COG0446	pyridine nucleotide-disulphide oxidoreductase
DFR86_RS05180	COG2222	sugar isomerase
DFR86_RS05200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DFR86_RS05210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DFR86_RS05215	COG1028	Short-chain dehydrogenase reductase Sdr
DFR86_RS05220	COG1573	uracil-dna glycosylase
DFR86_RS05250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DFR86_RS05270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR86_RS05275	COG1703	isobutyryl-CoA mutase activity
DFR86_RS05285	COG0596	Alpha beta hydrolase
DFR86_RS05305	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DFR86_RS05310	COG1881	PFAM PEBP family protein
DFR86_RS05320	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DFR86_RS05320	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DFR86_RS05325	COG0315	cyclic pyranopterin monophosphate synthase activity
DFR86_RS05385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR86_RS05410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DFR86_RS05415	COG1444	tRNA N-acetyltransferase activity
DFR86_RS05435	COG0589	response to stress
DFR86_RS05440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR86_RS05445	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DFR86_RS05445	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DFR86_RS05450	COG0009	L-threonylcarbamoyladenylate synthase
DFR86_RS05455	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR86_RS05460	COG2379	hydroxypyruvate reductase
DFR86_RS05470	COG1321	iron dependent repressor
DFR86_RS05500	COG1763	Mo-molybdopterin cofactor biosynthetic process
DFR86_RS05505	COG0303	'Molybdopterin
DFR86_RS05510	COG0746	molybdenum cofactor guanylyltransferase activity
DFR86_RS05555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS05575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR86_RS05600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DFR86_RS05615	COG1201	RNA secondary structure unwinding
DFR86_RS05625	COG0517	IMP dehydrogenase activity
DFR86_RS05625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DFR86_RS05625	COG0617	tRNA 3'-terminal CCA addition
DFR86_RS05650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DFR86_RS05655	COG1058	Belongs to the CinA family
DFR86_RS05655	COG1546	Belongs to the CinA family
DFR86_RS05660	COG2267	carboxylic ester hydrolase activity
DFR86_RS05675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DFR86_RS05710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DFR86_RS05715	COG1358	cellular component organization or biogenesis
DFR86_RS05730	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DFR86_RS05735	COG0142	geranyltranstransferase activity
DFR86_RS05740	COG1304	FMN binding
DFR86_RS05745	COG0528	UMP kinase activity
DFR86_RS05755	COG1355	regulation of microtubule-based process
DFR86_RS05770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DFR86_RS05775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DFR86_RS05790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DFR86_RS05795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DFR86_RS05800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DFR86_RS05820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DFR86_RS05830	COG0417	DNA replication proofreading
DFR86_RS05865	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DFR86_RS05885	COG3276	selenocysteine insertion sequence binding
DFR86_RS05900	COG0023	Translation Initiation Factor
DFR86_RS05910	COG0010	Belongs to the arginase family
DFR86_RS05915	COG0423	glycine-tRNA ligase activity
DFR86_RS05945	COG0163	prenyltransferase activity
DFR86_RS05955	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
DFR86_RS05970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DFR86_RS05975	COG0515	serine threonine protein kinase
DFR86_RS05975	COG2815	serine threonine protein kinase
DFR86_RS05980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DFR86_RS05985	COG0667	Aldo Keto reductase
DFR86_RS06030	COG1110	DNA topoisomerase II activity
DFR86_RS06035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS06040	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DFR86_RS06055	COG0557	exoribonuclease II activity
DFR86_RS06090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DFR86_RS06105	COG1797	cobyrinic acid a,c-diamide synthase activity
DFR86_RS06120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DFR86_RS06120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DFR86_RS06130	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DFR86_RS06160	COG1201	RNA secondary structure unwinding
DFR86_RS06175	COG2813	Specifically methylates the guanine in position
DFR86_RS06180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DFR86_RS06185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DFR86_RS06200	COG0051	transcription antitermination factor activity, RNA binding
DFR86_RS06210	COG0049	tRNA binding
DFR86_RS06235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DFR86_RS06240	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DFR86_RS06245	COG0085	RNA polymerase activity
DFR86_RS06255	COG0281	malic enzyme
DFR86_RS06260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DFR86_RS06280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DFR86_RS06290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFR86_RS06305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DFR86_RS06310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DFR86_RS06325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DFR86_RS06345	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DFR86_RS06355	COG1605	Chorismate mutase
DFR86_RS06355	COG0077	Prephenate dehydratase
DFR86_RS06360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DFR86_RS06380	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DFR86_RS06380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR86_RS06395	COG1051	belongs to the nudix hydrolase family
DFR86_RS06395	COG1056	cytidyltransferase-related domain
DFR86_RS06400	COG1607	acyl-coa hydrolase
DFR86_RS06445	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DFR86_RS06470	COG1121	(ABC) transporter
DFR86_RS06475	COG1980	fructose-bisphosphate aldolase activity
DFR86_RS06515	COG0124	histidyl-tRNA synthetase
DFR86_RS06535	COG0343	queuine tRNA-ribosyltransferase activity
DFR86_RS06550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS06560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DFR86_RS06595	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DFR86_RS06640	COG2264	protein methyltransferase activity
DFR86_RS06645	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DFR86_RS06655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DFR86_RS06660	COG0012	GTP binding
DFR86_RS06700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DFR86_RS06705	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DFR86_RS06735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DFR86_RS06740	COG1011	Hydrolase
DFR86_RS06755	COG0473	3-isopropylmalate dehydrogenase activity
DFR86_RS06760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DFR86_RS06775	COG0088	Forms part of the polypeptide exit tunnel
DFR86_RS06785	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DFR86_RS06790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DFR86_RS06795	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DFR86_RS06805	COG0255	Belongs to the universal ribosomal protein uL29 family
DFR86_RS06815	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DFR86_RS06825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DFR86_RS06835	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DFR86_RS06845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DFR86_RS06850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DFR86_RS06870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DFR86_RS06880	COG0200	Binds to the 23S rRNA
DFR86_RS06905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DFR86_RS06970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DFR86_RS06990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DFR86_RS07010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DFR86_RS07015	COG0504	CTP synthase activity
DFR86_RS07030	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
DFR86_RS07060	COG2078	PFAM AMMECR1 domain protein
DFR86_RS07075	COG0717	Belongs to the dCTP deaminase family
DFR86_RS07080	COG1793	dna ligase
DFR86_RS07090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DFR86_RS07115	COG0181	hydroxymethylbilane synthase activity
DFR86_RS07120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR86_RS07125	COG0113	porphobilinogen synthase activity
DFR86_RS07130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DFR86_RS07135	COG1648	precorrin-2 dehydrogenase activity
DFR86_RS07135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DFR86_RS07140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DFR86_RS07150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS07175	COG0017	Asparaginyl-tRNA synthetase
DFR86_RS07200	COG0028	Belongs to the TPP enzyme family
DFR86_RS07210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DFR86_RS07215	COG1047	Peptidyl-prolyl cis-trans
DFR86_RS07220	COG0371	Dehydrogenase
DFR86_RS07225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DFR86_RS07265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DFR86_RS07280	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DFR86_RS07285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DFR86_RS07300	COG0189	ligase activity
DFR86_RS07305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DFR86_RS07315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DFR86_RS07335	COG0516	GMP reductase activity
DFR86_RS07335	COG0517	IMP dehydrogenase activity
DFR86_RS07375	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DFR86_RS07380	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DFR86_RS07390	COG1957	nucleoside hydrolase
DFR86_RS07410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR86_RS07415	COG0515	serine threonine protein kinase
DFR86_RS07420	COG0251	oxidation-reduction process
DFR86_RS07440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DFR86_RS07440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DFR86_RS07445	COG2239	Acts as a magnesium transporter
DFR86_RS07455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS07465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DFR86_RS07510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DFR86_RS07550	COG3264	Mechanosensitive ion channel
DFR86_RS07550	COG1196	nuclear chromosome segregation
DFR86_RS07585	COG1720	tRNA m6t6A37 methyltransferase activity
DFR86_RS07590	COG0312	modulator of DNA gyrase
DFR86_RS07605	COG0037	tRNA processing
DFR86_RS07620	COG0513	Belongs to the DEAD box helicase family
DFR86_RS07705	COG0489	protein tyrosine kinase activity
DFR86_RS07720	COG1280	lysine exporter protein (LysE YggA)
DFR86_RS07745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DFR86_RS07755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DFR86_RS07785	COG0477	Major facilitator Superfamily
DFR86_RS07800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS07820	COG0425	Belongs to the sulfur carrier protein TusA family
DFR86_RS07855	COG0438	transferase activity, transferring glycosyl groups
DFR86_RS07870	COG2848	UPF0210 protein
DFR86_RS07875	COG3830	Belongs to the UPF0237 family
DFR86_RS07915	COG1063	alcohol dehydrogenase
DFR86_RS07925	COG1131	(ABC) transporter
DFR86_RS07935	COG1914	H( )-stimulated, divalent metal cation uptake system
DFR86_RS07955	COG0477	Major facilitator Superfamily
DFR86_RS07965	COG0501	Belongs to the peptidase M48B family
DFR86_RS07970	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DFR86_RS08010	COG1215	transferase activity, transferring glycosyl groups
DFR86_RS08020	COG0351	phosphomethylpyrimidine kinase
DFR86_RS08020	COG0352	thiamine-phosphate diphosphorylase activity
DFR86_RS08025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DFR86_RS08030	COG1234	tRNA 3'-trailer cleavage
DFR86_RS08070	COG0463	Glycosyl transferase, family 2
DFR86_RS08085	COG0501	Belongs to the peptidase M48B family
DFR86_RS08090	COG1063	alcohol dehydrogenase
DFR86_RS08110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DFR86_RS08110	COG0519	Catalyzes the synthesis of GMP from XMP
DFR86_RS08115	COG0501	Belongs to the peptidase M48B family
DFR86_RS08120	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DFR86_RS08125	COG1830	Aldolase
DFR86_RS08140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DFR86_RS08140	COG0517	IMP dehydrogenase activity
DFR86_RS08150	COG2971	BadF BadG BcrA BcrD
DFR86_RS08155	COG0405	Gamma-glutamyltransferase
DFR86_RS08170	COG1444	tRNA N-acetyltransferase activity
DFR86_RS08190	COG0589	response to stress
DFR86_RS08205	COG0864	Transcriptional regulator
DFR86_RS08215	COG0460	homoserine dehydrogenase
DFR86_RS08220	COG0109	protoheme IX farnesyltransferase activity
DFR86_RS08230	COG1024	Enoyl-CoA hydratase
DFR86_RS08270	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR86_RS08280	COG0189	ligase activity
DFR86_RS08295	COG0165	Argininosuccinate lyase
DFR86_RS08300	COG0137	argininosuccinate synthase activity
DFR86_RS08315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DFR86_RS08320	COG0151	Belongs to the GarS family
DFR86_RS08325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DFR86_RS08330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DFR86_RS08335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DFR86_RS08340	COG0047	phosphoribosylformylglycinamidine synthase activity
DFR86_RS08350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DFR86_RS08355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR86_RS08355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR86_RS08360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DFR86_RS08365	COG0602	queuosine metabolic process
DFR86_RS08395	COG0704	Plays a role in the regulation of phosphate uptake
DFR86_RS08405	COG0284	orotidine-5'-phosphate decarboxylase activity
DFR86_RS08410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DFR86_RS08415	COG0540	Belongs to the ATCase OTCase family
DFR86_RS08420	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
DFR86_RS08435	COG0167	dihydroorotate dehydrogenase activity
DFR86_RS08455	COG1522	sequence-specific DNA binding
DFR86_RS08470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR86_RS08475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DFR86_RS08480	COG2151	metal-sulfur cluster biosynthetic enzyme
DFR86_RS08490	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DFR86_RS08500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DFR86_RS08505	COG0107	imidazoleglycerol-phosphate synthase activity
DFR86_RS08510	COG0131	Imidazoleglycerol-phosphate dehydratase
DFR86_RS08515	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DFR86_RS08520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DFR86_RS08535	COG0495	leucyl-tRNA aminoacylation
DFR86_RS08540	COG2096	Adenosyltransferase
DFR86_RS08545	COG0037	tRNA processing
DFR86_RS08555	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DFR86_RS08570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DFR86_RS08580	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DFR86_RS08585	COG0546	phosphoglycolate phosphatase activity
DFR86_RS08590	COG0028	Belongs to the TPP enzyme family
DFR86_RS08615	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DFR86_RS08620	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DFR86_RS08630	COG0442	prolyl-tRNA aminoacylation
DFR86_RS08645	COG1394	ATPase activity, coupled to movement of substances
DFR86_RS08655	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
DFR86_RS08675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR86_RS08675	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR86_RS08705	COG0417	DNA replication proofreading
DFR86_RS08715	COG1260	myo-inositol-1-phosphate synthase
DFR86_RS08720	COG1007	ATP synthesis coupled electron transport
DFR86_RS08725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DFR86_RS08730	COG0713	ATP synthesis coupled electron transport
DFR86_RS08740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR86_RS08745	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DFR86_RS08750	COG0649	NAD binding
DFR86_RS08755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR86_RS08765	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DFR86_RS08785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DFR86_RS08820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DFR86_RS08835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DFR86_RS08845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DFR86_RS08850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DFR86_RS08855	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DFR86_RS08860	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DFR86_RS08865	COG0077	Prephenate dehydratase
DFR86_RS08865	COG1605	Chorismate mutase
DFR86_RS08870	COG3958	Transketolase
DFR86_RS08875	COG3959	Transketolase, thiamine diphosphate binding domain
DFR86_RS08880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DFR86_RS08910	COG1185	polyribonucleotide nucleotidyltransferase activity
DFR86_RS08935	COG0067	glutamate synthase
DFR86_RS08940	COG0069	glutamate synthase activity
DFR86_RS08965	COG1185	polyribonucleotide nucleotidyltransferase activity
DFR86_RS09000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DFR86_RS09010	COG1234	tRNA 3'-trailer cleavage
DFR86_RS09025	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DFR86_RS09055	COG1176	ABC-type spermidine putrescine transport system, permease component I
DFR86_RS09065	COG4221	oxidoreductase activity
DFR86_RS09080	COG2423	ornithine cyclodeaminase activity
DFR86_RS09100	COG0535	radical SAM domain protein
DFR86_RS09110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DFR86_RS09110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR86_RS09120	COG0318	PFAM AMP-dependent synthetase and ligase
DFR86_RS09125	COG3118	belongs to the thioredoxin family
DFR86_RS09130	COG3842	ATPase activity
DFR86_RS09145	COG0302	gtp cyclohydrolase
DFR86_RS09170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DFR86_RS09235	COG0552	protein localization to endoplasmic reticulum
DFR86_RS09250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DFR86_RS09255	COG0081	regulation of translation
DFR86_RS09260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DFR86_RS09290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DFR86_RS09310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DFR86_RS09315	COG0589	response to stress
DFR86_RS09325	COG0126	phosphoglycerate kinase activity
DFR86_RS09370	COG0396	ATPase activity
DFR86_RS09390	COG0509	glycine decarboxylation via glycine cleavage system
DFR86_RS09400	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DFR86_RS09405	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DFR86_RS09445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS09450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DFR86_RS09465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DFR86_RS09505	COG0525	valine-tRNA ligase activity
DFR86_RS09510	COG0436	Aminotransferase
DFR86_RS09515	COG0134	indole-3-glycerol-phosphate synthase activity
DFR86_RS09520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DFR86_RS09520	COG0512	Glutamine amidotransferase of anthranilate synthase
DFR86_RS09525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DFR86_RS09530	COG0135	phosphoribosylanthranilate isomerase activity
DFR86_RS09540	COG0159	tryptophan synthase activity
DFR86_RS09545	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DFR86_RS09550	COG1254	Belongs to the acylphosphatase family
DFR86_RS09565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DFR86_RS09565	COG0574	Belongs to the PEP-utilizing enzyme family
DFR86_RS09580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DFR86_RS09585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DFR86_RS09590	COG0527	aspartate kinase activity
DFR86_RS09590	COG0460	homoserine dehydrogenase
DFR86_RS09600	COG0613	PHP domain protein
DFR86_RS09610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DFR86_RS09640	COG0459	protein refolding
DFR86_RS09665	COG0018	arginyl-trna synthetase
DFR86_RS09695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFR86_RS09700	COG0252	asparaginase activity
DFR86_RS09780	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DFR86_RS09780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DFR86_RS09805	COG1324	tolerance protein
DFR86_RS09815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DFR86_RS09840	COG1110	DNA topoisomerase II activity
DFR86_RS09880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DFR86_RS09885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DFR86_RS09895	COG2084	Dehydrogenase
DFR86_RS09915	COG0528	UMP kinase activity
DFR86_RS09925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFR86_RS09935	COG0535	radical SAM domain protein
DFR86_RS09990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DFR86_RS09995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DFR86_RS10005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DFR86_RS10045	COG2235	arginine
DFR86_RS10055	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DFR86_RS10060	COG0004	ammonium transporteR
DFR86_RS10070	COG0438	transferase activity, transferring glycosyl groups
DFR86_RS10080	COG0589	response to stress
DFR86_RS10105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DFR86_RS10110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DFR86_RS10115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DFR86_RS10120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DFR86_RS10185	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DFR86_RS10230	COG0530	calcium, potassium:sodium antiporter activity
DFR86_RS10235	COG1522	sequence-specific DNA binding
DFR86_RS10240	COG3386	PFAM SMP-30 Gluconolaconase
DFR86_RS10300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DFR86_RS10310	COG0477	Major facilitator Superfamily
DFR86_RS10315	COG2814	Major facilitator Superfamily
DFR86_RS10340	COG1335	isochorismatase
DFR86_RS10350	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DFR86_RS10400	COG1573	uracil-dna glycosylase
DFR86_RS10410	COG0823	Involved in the tonB-independent uptake of proteins
DFR86_RS10410	COG4946	Tricorn protease homolog
DFR86_RS10410	COG1506	peptidase
DFR86_RS10435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS10450	COG2226	methyltransferase
DFR86_RS10455	COG1012	belongs to the aldehyde dehydrogenase family
DFR86_RS10465	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DFR86_RS10475	COG4946	Tricorn protease homolog
DFR86_RS10475	COG1506	peptidase
DFR86_RS10475	COG0823	Involved in the tonB-independent uptake of proteins
DFR86_RS10485	COG0446	pyridine nucleotide-disulphide oxidoreductase
DFR86_RS10495	COG1122	ATPase activity
DFR86_RS10530	COG0651	ATP synthesis coupled electron transport
DFR86_RS10540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR86_RS10545	COG0651	ATP synthesis coupled electron transport
DFR86_RS10550	COG0650	Formate hydrogenlyase subunit 4
DFR86_RS10570	COG3842	ATPase activity
DFR86_RS10585	COG0730	response to heat
DFR86_RS10590	COG0813	purine-nucleoside phosphorylase activity
DFR86_RS10660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DFR86_RS10680	COG0667	Aldo Keto reductase
DFR86_RS10725	COG0123	including yeast histone deacetylase and acetoin utilization protein
DFR86_RS10750	COG2210	Belongs to the sulfur carrier protein TusA family
DFR86_RS10755	COG0425	Belongs to the sulfur carrier protein TusA family
DFR86_RS10770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR86_RS10785	COG2048	Heterodisulfide reductase, subunit B
DFR86_RS10800	COG0509	glycine decarboxylation via glycine cleavage system
DFR86_RS10820	COG2814	Major facilitator Superfamily
DFR86_RS10825	COG0095	Lipoate-protein ligase
DFR86_RS10835	COG0095	Lipoate-protein ligase
DFR86_RS10845	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DFR86_RS10855	COG0450	alkyl hydroperoxide reductase
DFR86_RS10880	COG0509	glycine decarboxylation via glycine cleavage system
DFR86_RS10885	COG0095	Lipoate-protein ligase
DFR86_RS10905	COG0644	oxidoreductase
DFR86_RS10960	COG0475	glutathione-regulated potassium exporter activity
DFR86_RS10980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DFR86_RS10985	COG1305	Transglutaminase-like
DFR86_RS11005	COG0456	acetyltransferase
DFR86_RS11015	COG2217	Heavy metal translocating P-type atpase
DFR86_RS11020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DFR86_RS11020	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DFR86_RS11055	COG0425	Belongs to the sulfur carrier protein TusA family
DFR86_RS11070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DFR86_RS11070	COG0425	Belongs to the sulfur carrier protein TusA family
DFR86_RS11135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DFR86_RS11145	COG0805	protein transport
DFR86_RS11165	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR86_RS11175	COG0277	FAD linked oxidase domain protein
DFR86_RS11190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR86_RS11210	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS11215	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS11225	COG0535	radical SAM domain protein
DFR86_RS11230	COG0535	radical SAM domain protein
DFR86_RS11270	COG1271	oxidase subunit
DFR86_RS11290	COG0531	amino acid
DFR86_RS11300	COG1960	acyl-CoA dehydrogenase activity
DFR86_RS11310	COG1960	acyl-CoA dehydrogenase activity
DFR86_RS11315	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DFR86_RS11365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DFR86_RS11375	COG2878	Part of a membrane complex involved in electron transport
DFR86_RS11525	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DFR86_RS11620	COG1337	RAMP superfamily