locus-tag	class	description
DFR86_RS00060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DFR86_RS11955	COG0584	glycerophosphoryl diester phosphodiesterase
DFR86_RS11970	COG1373	ATPase (AAA superfamily
DFR86_RS11975	COG1131	(ABC) transporter
DFR86_RS11995	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DFR86_RS12070	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DFR86_RS12075	COG0437	4 iron, 4 sulfur cluster binding
DFR86_RS12110	COG1175	transmembrane transport
DFR86_RS12115	COG3833	ABC-type maltose transport systems, permease component
DFR86_RS12120	COG3842	ATPase activity
DFR86_RS12145	COG0515	serine threonine protein kinase
DFR86_RS12145	COG2815	serine threonine protein kinase
DFR86_RS12160	COG1201	RNA secondary structure unwinding
DFR86_RS12180	COG0433	COG0433 Predicted ATPase
DFR86_RS12215	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DFR86_RS12250	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS12255	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS12260	COG1144	Oxidoreductase
DFR86_RS12270	COG1960	acyl-CoA dehydrogenase activity
DFR86_RS12285	COG0437	4 iron, 4 sulfur cluster binding
DFR86_RS12315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS12320	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR86_RS12335	COG0183	Belongs to the thiolase family
DFR86_RS12340	COG1024	Enoyl-CoA hydratase
DFR86_RS12360	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR86_RS12420	COG1215	transferase activity, transferring glycosyl groups
DFR86_RS12480	COG1373	ATPase (AAA superfamily
DFR86_RS12515	COG1177	transmembrane transport
DFR86_RS12525	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DFR86_RS12545	COG1373	ATPase (AAA superfamily
DFR86_RS12630	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DFR86_RS12635	COG1091	dTDP-4-dehydrorhamnose reductase activity
DFR86_RS12645	COG2192	nodulation
DFR86_RS12650	COG1215	transferase activity, transferring glycosyl groups
DFR86_RS12675	COG1216	Glycosyl transferase, family 2
DFR86_RS12680	COG1442	glycosyl transferase family 8
DFR86_RS12680	COG1216	Glycosyl transferase, family 2
DFR86_RS12685	COG1216	Glycosyl transferase, family 2
DFR86_RS12735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DFR86_RS12765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DFR86_RS12790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS12815	COG1960	acyl-CoA dehydrogenase activity
DFR86_RS12820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS12830	COG0601	transmembrane transport
DFR86_RS12835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR86_RS12840	COG0444	Belongs to the ABC transporter superfamily
DFR86_RS12845	COG4608	Belongs to the ABC transporter superfamily
DFR86_RS12860	COG0519	Catalyzes the synthesis of GMP from XMP
DFR86_RS12905	COG1473	amidohydrolase
DFR86_RS12925	COG0531	amino acid
DFR86_RS12930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS12985	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DFR86_RS13000	COG2814	Major facilitator Superfamily
DFR86_RS13005	COG0243	molybdopterin cofactor binding
DFR86_RS13010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS13015	COG2084	Dehydrogenase
DFR86_RS13025	COG0247	lactate metabolic process
DFR86_RS13030	COG1592	Rubrerythrin
DFR86_RS13035	COG0028	Belongs to the TPP enzyme family
DFR86_RS13040	COG0446	pyridine nucleotide-disulphide oxidoreductase
DFR86_RS13050	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DFR86_RS13055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS13095	COG0039	L-malate dehydrogenase activity
DFR86_RS13100	COG2079	MmgE PrpD family protein
DFR86_RS13105	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DFR86_RS13110	COG0517	IMP dehydrogenase activity
DFR86_RS13110	COG0516	GMP reductase activity
DFR86_RS13115	COG0372	Belongs to the citrate synthase family
DFR86_RS13165	COG0525	valine-tRNA ligase activity
DFR86_RS13195	COG1028	Short-chain dehydrogenase reductase Sdr
DFR86_RS13215	COG2271	Major facilitator Superfamily
DFR86_RS13245	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DFR86_RS13250	COG0114	fumarate hydratase activity
DFR86_RS13255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR86_RS13345	COG2860	membrane
DFR86_RS13355	COG1131	(ABC) transporter
DFR86_RS13370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DFR86_RS13370	COG1042	CoA-binding domain protein
DFR86_RS13370	COG0045	succinate-CoA ligase (ADP-forming) activity
DFR86_RS13380	COG0531	amino acid
DFR86_RS13385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS13390	COG1063	alcohol dehydrogenase
DFR86_RS13430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DFR86_RS13435	COG0066	3-isopropylmalate dehydratase activity
DFR86_RS13440	COG0778	Nitroreductase
DFR86_RS13470	COG0157	Belongs to the NadC ModD family
DFR86_RS13475	COG0519	Catalyzes the synthesis of GMP from XMP
DFR86_RS13475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DFR86_RS13485	COG0351	phosphomethylpyrimidine kinase
DFR86_RS13485	COG0352	thiamine-phosphate diphosphorylase activity
DFR86_RS13485	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DFR86_RS13490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DFR86_RS13510	COG0708	Exodeoxyribonuclease III
DFR86_RS13520	COG5599	Phosphatase
DFR86_RS13525	COG1515	deoxyribonuclease V activity
DFR86_RS13540	COG0450	alkyl hydroperoxide reductase
DFR86_RS13555	COG0372	Belongs to the citrate synthase family
DFR86_RS13575	COG4581	dead DEAH box helicase
DFR86_RS13580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DFR86_RS13590	COG0439	Biotin carboxylase
DFR86_RS13600	COG1116	anion transmembrane transporter activity
DFR86_RS13610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DFR86_RS13640	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS13650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR86_RS13660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS13680	COG0301	tRNA thio-modification
DFR86_RS13680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DFR86_RS13695	COG0477	Major facilitator Superfamily
DFR86_RS13710	COG0671	phosphoesterase, PA-phosphatase related
DFR86_RS13715	COG2226	methyltransferase
DFR86_RS13725	COG0243	molybdopterin cofactor binding
DFR86_RS13765	COG0513	Belongs to the DEAD box helicase family
DFR86_RS13810	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DFR86_RS13815	COG0123	including yeast histone deacetylase and acetoin utilization protein
DFR86_RS13825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DFR86_RS13845	COG1192	Involved in chromosome partitioning
DFR86_RS13860	COG1695	Transcriptional regulator
DFR86_RS13880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DFR86_RS13890	COG1131	(ABC) transporter
DFR86_RS13900	COG1024	Enoyl-CoA hydratase
DFR86_RS13905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS13925	COG0438	transferase activity, transferring glycosyl groups
DFR86_RS13930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR86_RS13970	COG1331	Highly conserved protein containing a thioredoxin domain
DFR86_RS13980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DFR86_RS14040	COG0330	HflC and HflK could
DFR86_RS14065	COG2154	pterin-4-alpha-carbinolamine dehydratase
DFR86_RS14080	COG0538	isocitrate dehydrogenase activity
DFR86_RS14135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DFR86_RS14135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DFR86_RS14140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DFR86_RS14180	COG0537	adenosine 5'-monophosphoramidase activity
DFR86_RS14185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DFR86_RS14195	COG0154	amidase activity
DFR86_RS14205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR86_RS14210	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DFR86_RS14210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DFR86_RS14230	COG0497	DNA recombination
DFR86_RS14265	COG0735	belongs to the Fur family
DFR86_RS14285	COG0516	GMP reductase activity
DFR86_RS14285	COG0517	IMP dehydrogenase activity
DFR86_RS14320	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DFR86_RS14375	COG0492	ferredoxin-NADP+ reductase activity
DFR86_RS14385	COG2814	Major facilitator Superfamily
DFR86_RS14390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DFR86_RS14410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DFR86_RS14420	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DFR86_RS14435	COG0561	phosphatase activity
DFR86_RS14480	COG0517	IMP dehydrogenase activity
DFR86_RS14480	COG0516	GMP reductase activity
DFR86_RS14485	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DFR86_RS14490	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR86_RS14510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DFR86_RS14520	COG0297	glycogen (starch) synthase activity
DFR86_RS14570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR86_RS14575	COG0546	phosphoglycolate phosphatase activity
DFR86_RS14585	COG1061	Type III restriction enzyme res subunit
DFR86_RS14655	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DFR86_RS14660	COG1051	belongs to the nudix hydrolase family
DFR86_RS14665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS14670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DFR86_RS14675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DFR86_RS14685	COG0430	RNA-3'-phosphate cyclase activity
DFR86_RS14695	COG0174	glutamine synthetase
DFR86_RS14730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DFR86_RS14730	COG1648	precorrin-2 dehydrogenase activity
DFR86_RS14750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DFR86_RS14775	COG0071	Belongs to the small heat shock protein (HSP20) family
DFR86_RS14780	COG0346	lactoylglutathione lyase activity
DFR86_RS14785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR86_RS14785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR86_RS14790	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DFR86_RS14805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS14815	COG0492	ferredoxin-NADP+ reductase activity
DFR86_RS14830	COG0720	synthase
DFR86_RS14860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFR86_RS14865	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DFR86_RS14890	COG4555	ABC transporter
DFR86_RS14900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DFR86_RS14930	COG0351	phosphomethylpyrimidine kinase
DFR86_RS14985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR86_RS14990	COG0183	Belongs to the thiolase family
DFR86_RS15030	COG0626	cystathionine gamma-synthase activity
DFR86_RS15035	COG0083	homoserine kinase activity
DFR86_RS15055	COG0714	Associated with various cellular activities
DFR86_RS15060	COG2304	oxidoreductase activity
DFR86_RS15085	COG0647	UMP catabolic process
DFR86_RS15100	COG0644	oxidoreductase
DFR86_RS15115	COG1446	asparaginase
DFR86_RS15130	COG1522	sequence-specific DNA binding
DFR86_RS15135	COG0569	domain protein
DFR86_RS15135	COG0189	ligase activity
DFR86_RS15140	COG0142	geranyltranstransferase activity
DFR86_RS15150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DFR86_RS15155	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DFR86_RS15185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DFR86_RS15220	COG4555	ABC transporter
DFR86_RS15275	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DFR86_RS15315	COG0477	Major facilitator Superfamily
DFR86_RS15320	COG2814	Major facilitator Superfamily
DFR86_RS15325	COG0750	zinc metalloprotease
DFR86_RS15360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR86_RS15365	COG0477	Major facilitator Superfamily
DFR86_RS15375	COG2723	6-phospho-beta-galactosidase activity
DFR86_RS15380	COG3387	PFAM Glycoside hydrolase 15-related
DFR86_RS15385	COG2308	Evidence 4 Homologs of previously reported genes of
DFR86_RS15400	COG0640	Transcriptional regulator
DFR86_RS15410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR86_RS15420	COG4139	cobalamin transport
DFR86_RS15425	COG1121	(ABC) transporter
DFR86_RS15445	COG2814	Major facilitator Superfamily
DFR86_RS15455	COG0730	response to heat
DFR86_RS15465	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DFR86_RS15505	COG1131	(ABC) transporter
DFR86_RS15530	COG0589	response to stress
DFR86_RS15545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DFR86_RS15560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DFR86_RS15560	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS15565	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS15575	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DFR86_RS15580	COG1733	regulation of RNA biosynthetic process
DFR86_RS15595	COG1131	(ABC) transporter
DFR86_RS15610	COG0531	amino acid
DFR86_RS15625	COG3383	formate dehydrogenase (NAD+) activity
DFR86_RS15635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DFR86_RS15710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS15730	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DFR86_RS15735	COG0375	protein maturation
DFR86_RS15765	COG0309	Hydrogenase expression formation protein (HypE)
DFR86_RS15775	COG0409	Hydrogenase expression formation protein
DFR86_RS15815	COG2226	methyltransferase
DFR86_RS15840	COG0243	molybdopterin cofactor binding
DFR86_RS15920	COG1522	sequence-specific DNA binding
DFR86_RS15930	COG0477	Major facilitator Superfamily
DFR86_RS15935	COG0277	FAD linked oxidase domain protein
DFR86_RS15970	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DFR86_RS15980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR86_RS15985	COG0402	S-adenosylhomocysteine deaminase activity
DFR86_RS15995	COG1953	Uracil, thiamine, allantoin
DFR86_RS16035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DFR86_RS16035	COG2080	2 iron, 2 sulfur cluster binding
DFR86_RS16040	COG0402	S-adenosylhomocysteine deaminase activity
DFR86_RS16045	COG2235	arginine
DFR86_RS16055	COG0531	amino acid
DFR86_RS16060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR86_RS16090	COG0402	S-adenosylhomocysteine deaminase activity
DFR86_RS16100	COG0831	urea catabolic process
DFR86_RS16100	COG0832	Belongs to the urease beta subunit family
DFR86_RS16115	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DFR86_RS16145	COG4948	Mandelate Racemase Muconate Lactonizing
DFR86_RS16160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS16190	COG4948	Mandelate Racemase Muconate Lactonizing
DFR86_RS16200	COG1132	(ABC) transporter
DFR86_RS16215	COG4608	Belongs to the ABC transporter superfamily
DFR86_RS16220	COG0444	Belongs to the ABC transporter superfamily
DFR86_RS16225	COG0601	transmembrane transport
DFR86_RS16235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR86_RS16255	COG0477	Major facilitator Superfamily
DFR86_RS16285	COG0601	transmembrane transport
DFR86_RS16290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DFR86_RS16300	COG4608	Belongs to the ABC transporter superfamily
DFR86_RS16315	COG0281	malic enzyme
DFR86_RS16330	COG0531	amino acid
DFR86_RS16335	COG0469	pyruvate kinase activity
DFR86_RS16340	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DFR86_RS16340	COG3608	succinylglutamate desuccinylase aspartoacylase
DFR86_RS16360	COG2814	Major facilitator Superfamily
DFR86_RS16405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DFR86_RS16405	COG0574	Belongs to the PEP-utilizing enzyme family
DFR86_RS16410	COG1584	GPR1 FUN34 yaaH family protein
DFR86_RS16415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR86_RS16430	COG2368	4-hydroxyphenylacetate
DFR86_RS16440	COG0477	Major facilitator Superfamily
DFR86_RS16450	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DFR86_RS16455	COG0179	Fumarylacetoacetate (FAA) hydrolase
DFR86_RS16460	COG3384	dioxygenase
DFR86_RS16465	COG2226	methyltransferase
DFR86_RS16480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS16485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS16550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR86_RS16560	COG1139	Iron-sulfur cluster binding protein
DFR86_RS16570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DFR86_RS16585	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DFR86_RS16595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DFR86_RS16600	COG0731	radical SAM domain protein
DFR86_RS16600	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DFR86_RS16610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR86_RS16625	COG1505	serine-type exopeptidase activity
DFR86_RS16635	COG0277	FAD linked oxidase domain protein
DFR86_RS16645	COG2814	Major facilitator Superfamily
DFR86_RS16670	COG3387	PFAM Glycoside hydrolase 15-related
DFR86_RS16725	COG1741	Belongs to the pirin family
DFR86_RS16745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DFR86_RS16760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR86_RS16765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR86_RS16775	COG2062	phosphohistidine phosphatase, SixA
DFR86_RS16810	COG0477	Major facilitator Superfamily
DFR86_RS16830	COG2271	Major facilitator Superfamily
DFR86_RS16885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFR86_RS16895	COG0109	protoheme IX farnesyltransferase activity
DFR86_RS16910	COG1960	acyl-CoA dehydrogenase activity
DFR86_RS16915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DFR86_RS16925	COG1607	acyl-coa hydrolase
DFR86_RS16945	COG0446	pyridine nucleotide-disulphide oxidoreductase
DFR86_RS16955	COG2222	sugar isomerase
DFR86_RS16975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DFR86_RS16985	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DFR86_RS16990	COG1028	Short-chain dehydrogenase reductase Sdr
DFR86_RS16995	COG1573	uracil-dna glycosylase
DFR86_RS17025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DFR86_RS17045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DFR86_RS17050	COG1703	isobutyryl-CoA mutase activity
DFR86_RS17060	COG0596	Alpha beta hydrolase
DFR86_RS17080	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DFR86_RS17085	COG1881	PFAM PEBP family protein
DFR86_RS17095	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DFR86_RS17095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DFR86_RS17100	COG0315	cyclic pyranopterin monophosphate synthase activity
DFR86_RS17155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DFR86_RS17180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DFR86_RS17185	COG1444	tRNA N-acetyltransferase activity
DFR86_RS17205	COG0589	response to stress
DFR86_RS17210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR86_RS17215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DFR86_RS17215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DFR86_RS17220	COG0009	L-threonylcarbamoyladenylate synthase
DFR86_RS17225	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR86_RS17230	COG2379	hydroxypyruvate reductase
DFR86_RS17240	COG1321	iron dependent repressor
DFR86_RS17270	COG1763	Mo-molybdopterin cofactor biosynthetic process
DFR86_RS17275	COG0303	'Molybdopterin
DFR86_RS17280	COG0746	molybdenum cofactor guanylyltransferase activity
DFR86_RS17325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DFR86_RS17350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR86_RS17375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DFR86_RS17390	COG1201	RNA secondary structure unwinding
DFR86_RS17395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DFR86_RS17395	COG0617	tRNA 3'-terminal CCA addition
DFR86_RS17395	COG3620	sequence-specific DNA binding
DFR86_RS17420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DFR86_RS17425	COG1546	Belongs to the CinA family
DFR86_RS17425	COG1058	Belongs to the CinA family
DFR86_RS17430	COG2267	carboxylic ester hydrolase activity
DFR86_RS17445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DFR86_RS17480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DFR86_RS17485	COG1358	cellular component organization or biogenesis
DFR86_RS17500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DFR86_RS17505	COG0142	geranyltranstransferase activity
DFR86_RS17510	COG1304	FMN binding
DFR86_RS17515	COG0528	UMP kinase activity
DFR86_RS17525	COG1355	regulation of microtubule-based process
DFR86_RS17540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DFR86_RS17545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DFR86_RS17560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DFR86_RS17565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DFR86_RS17570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DFR86_RS17590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DFR86_RS17600	COG0417	DNA replication proofreading
DFR86_RS17635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DFR86_RS17655	COG3276	selenocysteine insertion sequence binding
DFR86_RS17670	COG0023	Translation Initiation Factor
DFR86_RS17680	COG0010	Belongs to the arginase family
DFR86_RS17685	COG0423	glycine-tRNA ligase activity
DFR86_RS17715	COG0163	prenyltransferase activity
DFR86_RS17725	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
DFR86_RS17740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DFR86_RS17745	COG2815	serine threonine protein kinase
DFR86_RS17745	COG0515	serine threonine protein kinase
DFR86_RS17750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DFR86_RS17755	COG0667	Aldo Keto reductase
DFR86_RS17800	COG1110	DNA topoisomerase II activity
DFR86_RS17805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS17810	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
DFR86_RS17825	COG0557	exoribonuclease II activity
DFR86_RS17860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DFR86_RS17875	COG1797	cobyrinic acid a,c-diamide synthase activity
DFR86_RS17890	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DFR86_RS17890	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DFR86_RS17900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DFR86_RS17930	COG1201	RNA secondary structure unwinding
DFR86_RS17945	COG2813	Specifically methylates the guanine in position
DFR86_RS17950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DFR86_RS17955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DFR86_RS17970	COG0051	transcription antitermination factor activity, RNA binding
DFR86_RS17980	COG0049	tRNA binding
DFR86_RS18005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DFR86_RS18010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DFR86_RS18015	COG0085	RNA polymerase activity
DFR86_RS18025	COG0281	malic enzyme
DFR86_RS18030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DFR86_RS18050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DFR86_RS18060	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFR86_RS18075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DFR86_RS18080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DFR86_RS18095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DFR86_RS18115	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DFR86_RS18125	COG1605	Chorismate mutase
DFR86_RS18125	COG0077	Prephenate dehydratase
DFR86_RS18130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DFR86_RS18150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR86_RS18150	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
DFR86_RS18165	COG1051	belongs to the nudix hydrolase family
DFR86_RS18165	COG1056	cytidyltransferase-related domain
DFR86_RS18170	COG1607	acyl-coa hydrolase
DFR86_RS18215	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DFR86_RS18245	COG1121	(ABC) transporter
DFR86_RS18250	COG1980	fructose-bisphosphate aldolase activity
DFR86_RS18290	COG0124	histidyl-tRNA synthetase
DFR86_RS18310	COG0343	queuine tRNA-ribosyltransferase activity
DFR86_RS18325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS18335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DFR86_RS18370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DFR86_RS18415	COG2264	protein methyltransferase activity
DFR86_RS18420	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DFR86_RS18430	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DFR86_RS18435	COG0012	GTP binding
DFR86_RS18475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DFR86_RS18480	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DFR86_RS18510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DFR86_RS18515	COG1011	Hydrolase
DFR86_RS18530	COG0473	3-isopropylmalate dehydrogenase activity
DFR86_RS18535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DFR86_RS18550	COG0088	Forms part of the polypeptide exit tunnel
DFR86_RS18560	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DFR86_RS18565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DFR86_RS18570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DFR86_RS18580	COG0255	Belongs to the universal ribosomal protein uL29 family
DFR86_RS18590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DFR86_RS18600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DFR86_RS18610	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DFR86_RS18620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DFR86_RS18625	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DFR86_RS18645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DFR86_RS18655	COG0200	Binds to the 23S rRNA
DFR86_RS18675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DFR86_RS18740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DFR86_RS18760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DFR86_RS18780	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DFR86_RS18785	COG0504	CTP synthase activity
DFR86_RS18800	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
DFR86_RS18830	COG2078	PFAM AMMECR1 domain protein
DFR86_RS18845	COG0717	Belongs to the dCTP deaminase family
DFR86_RS18850	COG1793	dna ligase
DFR86_RS18860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DFR86_RS18885	COG0181	hydroxymethylbilane synthase activity
DFR86_RS18890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DFR86_RS18895	COG0113	porphobilinogen synthase activity
DFR86_RS18900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DFR86_RS18905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DFR86_RS18905	COG1648	precorrin-2 dehydrogenase activity
DFR86_RS18910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DFR86_RS18920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS18945	COG0017	Asparaginyl-tRNA synthetase
DFR86_RS18970	COG0028	Belongs to the TPP enzyme family
DFR86_RS18980	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DFR86_RS18985	COG1047	Peptidyl-prolyl cis-trans
DFR86_RS18990	COG0371	Dehydrogenase
DFR86_RS18995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DFR86_RS19035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DFR86_RS19050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DFR86_RS19055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DFR86_RS19070	COG0189	ligase activity
DFR86_RS19075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DFR86_RS19085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DFR86_RS19105	COG0517	IMP dehydrogenase activity
DFR86_RS19105	COG0516	GMP reductase activity
DFR86_RS19150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DFR86_RS19155	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DFR86_RS19165	COG1957	nucleoside hydrolase
DFR86_RS19185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DFR86_RS19190	COG0515	serine threonine protein kinase
DFR86_RS19195	COG0251	oxidation-reduction process
DFR86_RS19215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DFR86_RS19215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DFR86_RS19220	COG2239	Acts as a magnesium transporter
DFR86_RS19230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS19240	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DFR86_RS19285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DFR86_RS19325	COG3264	Mechanosensitive ion channel
DFR86_RS19325	COG1196	nuclear chromosome segregation
DFR86_RS19360	COG1720	tRNA m6t6A37 methyltransferase activity
DFR86_RS19365	COG0312	modulator of DNA gyrase
DFR86_RS19380	COG0037	tRNA processing
DFR86_RS19395	COG0513	Belongs to the DEAD box helicase family
DFR86_RS19490	COG0489	protein tyrosine kinase activity
DFR86_RS19505	COG1280	lysine exporter protein (LysE YggA)
DFR86_RS19530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DFR86_RS19540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DFR86_RS19570	COG0477	Major facilitator Superfamily
DFR86_RS19585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS19605	COG0425	Belongs to the sulfur carrier protein TusA family
DFR86_RS19640	COG0438	transferase activity, transferring glycosyl groups
DFR86_RS19655	COG2848	UPF0210 protein
DFR86_RS19660	COG3830	Belongs to the UPF0237 family
DFR86_RS19700	COG1063	alcohol dehydrogenase
DFR86_RS19710	COG1131	(ABC) transporter
DFR86_RS19720	COG1914	H( )-stimulated, divalent metal cation uptake system
DFR86_RS19740	COG0477	Major facilitator Superfamily
DFR86_RS19750	COG0501	Belongs to the peptidase M48B family
DFR86_RS19755	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DFR86_RS19795	COG1215	transferase activity, transferring glycosyl groups
DFR86_RS19805	COG0351	phosphomethylpyrimidine kinase
DFR86_RS19805	COG0352	thiamine-phosphate diphosphorylase activity
DFR86_RS19810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DFR86_RS19815	COG1234	tRNA 3'-trailer cleavage
DFR86_RS19855	COG0463	Glycosyl transferase, family 2
DFR86_RS19870	COG0501	Belongs to the peptidase M48B family
DFR86_RS19875	COG1063	alcohol dehydrogenase
DFR86_RS19895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DFR86_RS19895	COG0519	Catalyzes the synthesis of GMP from XMP
DFR86_RS19900	COG0501	Belongs to the peptidase M48B family
DFR86_RS19905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DFR86_RS19910	COG1830	Aldolase
DFR86_RS19925	COG0517	IMP dehydrogenase activity
DFR86_RS19925	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DFR86_RS19935	COG2971	BadF BadG BcrA BcrD
DFR86_RS19940	COG0405	Gamma-glutamyltransferase
DFR86_RS19955	COG1444	tRNA N-acetyltransferase activity
DFR86_RS19975	COG0589	response to stress
DFR86_RS19990	COG0864	Transcriptional regulator
DFR86_RS20000	COG0460	homoserine dehydrogenase
DFR86_RS20005	COG0109	protoheme IX farnesyltransferase activity
DFR86_RS20015	COG1024	Enoyl-CoA hydratase
DFR86_RS20055	COG1250	3-hydroxyacyl-CoA dehydrogenase
DFR86_RS20065	COG0189	ligase activity
DFR86_RS20080	COG0165	Argininosuccinate lyase
DFR86_RS20085	COG0137	argininosuccinate synthase activity
DFR86_RS20100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DFR86_RS20105	COG0151	Belongs to the GarS family
DFR86_RS20110	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DFR86_RS20115	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DFR86_RS20120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DFR86_RS20125	COG0047	phosphoribosylformylglycinamidine synthase activity
DFR86_RS20135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DFR86_RS20140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR86_RS20140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR86_RS20145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DFR86_RS20150	COG0602	queuosine metabolic process
DFR86_RS20180	COG0704	Plays a role in the regulation of phosphate uptake
DFR86_RS20190	COG0284	orotidine-5'-phosphate decarboxylase activity
DFR86_RS20195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DFR86_RS20200	COG0540	Belongs to the ATCase OTCase family
DFR86_RS20205	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
DFR86_RS20220	COG0167	dihydroorotate dehydrogenase activity
DFR86_RS20240	COG1522	sequence-specific DNA binding
DFR86_RS20255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DFR86_RS20260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DFR86_RS20265	COG2151	metal-sulfur cluster biosynthetic enzyme
DFR86_RS20275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DFR86_RS20285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DFR86_RS20290	COG0107	imidazoleglycerol-phosphate synthase activity
DFR86_RS20295	COG0131	Imidazoleglycerol-phosphate dehydratase
DFR86_RS20300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DFR86_RS20305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DFR86_RS20320	COG0495	leucyl-tRNA aminoacylation
DFR86_RS20325	COG2096	Adenosyltransferase
DFR86_RS20330	COG0037	tRNA processing
DFR86_RS20340	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DFR86_RS20355	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DFR86_RS20365	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DFR86_RS20370	COG0546	phosphoglycolate phosphatase activity
DFR86_RS20375	COG0028	Belongs to the TPP enzyme family
DFR86_RS20400	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DFR86_RS20405	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DFR86_RS20415	COG0442	prolyl-tRNA aminoacylation
DFR86_RS20430	COG1394	ATPase activity, coupled to movement of substances
DFR86_RS20440	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
DFR86_RS20460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR86_RS20460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DFR86_RS20490	COG0417	DNA replication proofreading
DFR86_RS20500	COG1260	myo-inositol-1-phosphate synthase
DFR86_RS20505	COG1007	ATP synthesis coupled electron transport
DFR86_RS20510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DFR86_RS20515	COG0713	ATP synthesis coupled electron transport
DFR86_RS20525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR86_RS20530	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DFR86_RS20535	COG0649	NAD binding
DFR86_RS20540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR86_RS20550	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DFR86_RS20570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DFR86_RS20605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DFR86_RS20620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DFR86_RS20630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DFR86_RS20635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DFR86_RS20640	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DFR86_RS20645	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DFR86_RS20650	COG1605	Chorismate mutase
DFR86_RS20650	COG0077	Prephenate dehydratase
DFR86_RS20655	COG3958	Transketolase
DFR86_RS20660	COG3959	Transketolase, thiamine diphosphate binding domain
DFR86_RS20665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DFR86_RS20695	COG1185	polyribonucleotide nucleotidyltransferase activity
DFR86_RS20720	COG0067	glutamate synthase
DFR86_RS20725	COG0069	glutamate synthase activity
DFR86_RS20750	COG1185	polyribonucleotide nucleotidyltransferase activity
DFR86_RS20785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DFR86_RS20795	COG1234	tRNA 3'-trailer cleavage
DFR86_RS20810	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DFR86_RS20835	COG1176	ABC-type spermidine putrescine transport system, permease component I
DFR86_RS20845	COG4221	oxidoreductase activity
DFR86_RS20860	COG2423	ornithine cyclodeaminase activity
DFR86_RS20880	COG0535	radical SAM domain protein
DFR86_RS20890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DFR86_RS20890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DFR86_RS20900	COG0318	PFAM AMP-dependent synthetase and ligase
DFR86_RS20905	COG3118	belongs to the thioredoxin family
DFR86_RS20910	COG3842	ATPase activity
DFR86_RS20925	COG0302	gtp cyclohydrolase
DFR86_RS20950	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DFR86_RS21015	COG0552	protein localization to endoplasmic reticulum
DFR86_RS21030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DFR86_RS21035	COG0081	regulation of translation
DFR86_RS21040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DFR86_RS21050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DFR86_RS21070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DFR86_RS21090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DFR86_RS21095	COG0589	response to stress
DFR86_RS21105	COG0126	phosphoglycerate kinase activity
DFR86_RS21150	COG0396	ATPase activity
DFR86_RS21170	COG0509	glycine decarboxylation via glycine cleavage system
DFR86_RS21180	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DFR86_RS21185	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DFR86_RS21225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DFR86_RS21230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DFR86_RS21245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DFR86_RS21285	COG0525	valine-tRNA ligase activity
DFR86_RS21290	COG0436	Aminotransferase
DFR86_RS21295	COG0134	indole-3-glycerol-phosphate synthase activity
DFR86_RS21300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DFR86_RS21300	COG0512	Glutamine amidotransferase of anthranilate synthase
DFR86_RS21305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DFR86_RS21310	COG0135	phosphoribosylanthranilate isomerase activity
DFR86_RS21320	COG0159	tryptophan synthase activity
DFR86_RS21325	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
DFR86_RS21330	COG1254	Belongs to the acylphosphatase family
DFR86_RS21340	COG0574	Belongs to the PEP-utilizing enzyme family
DFR86_RS21340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DFR86_RS21355	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DFR86_RS21360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DFR86_RS21365	COG0527	aspartate kinase activity
DFR86_RS21365	COG0460	homoserine dehydrogenase
DFR86_RS21375	COG0613	PHP domain protein
DFR86_RS21385	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DFR86_RS21420	COG0459	protein refolding
DFR86_RS21445	COG0018	arginyl-trna synthetase
DFR86_RS21475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DFR86_RS21480	COG0252	asparaginase activity
DFR86_RS21510	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
DFR86_RS21560	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DFR86_RS21560	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DFR86_RS21575	COG0154	amidase activity
DFR86_RS21585	COG1324	tolerance protein
DFR86_RS21595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DFR86_RS21620	COG1110	DNA topoisomerase II activity
DFR86_RS21665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DFR86_RS21670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DFR86_RS21680	COG2084	Dehydrogenase
DFR86_RS21700	COG0528	UMP kinase activity
DFR86_RS21710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DFR86_RS21720	COG0535	radical SAM domain protein
DFR86_RS21775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DFR86_RS21780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DFR86_RS21790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DFR86_RS21830	COG2235	arginine
DFR86_RS21840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DFR86_RS21845	COG0004	ammonium transporteR
DFR86_RS21855	COG0438	transferase activity, transferring glycosyl groups
DFR86_RS21865	COG0589	response to stress
DFR86_RS21890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DFR86_RS21895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DFR86_RS21900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DFR86_RS21905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DFR86_RS21970	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DFR86_RS22015	COG0530	calcium, potassium:sodium antiporter activity
DFR86_RS22020	COG1522	sequence-specific DNA binding
DFR86_RS22025	COG3386	PFAM SMP-30 Gluconolaconase
DFR86_RS22080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DFR86_RS22090	COG0477	Major facilitator Superfamily
DFR86_RS22095	COG2814	Major facilitator Superfamily
DFR86_RS22115	COG1335	isochorismatase
DFR86_RS22125	COG1234	tRNA 3'-trailer cleavage
DFR86_RS22170	COG1573	uracil-dna glycosylase
DFR86_RS22180	COG1506	peptidase
DFR86_RS22180	COG4946	Tricorn protease homolog
DFR86_RS22180	COG0823	Involved in the tonB-independent uptake of proteins
DFR86_RS22205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DFR86_RS22220	COG2226	methyltransferase
DFR86_RS22225	COG1012	belongs to the aldehyde dehydrogenase family
DFR86_RS22235	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DFR86_RS22245	COG0823	Involved in the tonB-independent uptake of proteins
DFR86_RS22245	COG1506	peptidase
DFR86_RS22245	COG4946	Tricorn protease homolog
DFR86_RS22255	COG0446	pyridine nucleotide-disulphide oxidoreductase
DFR86_RS22265	COG1122	ATPase activity
DFR86_RS22300	COG0651	ATP synthesis coupled electron transport
DFR86_RS22305	COG0649	NAD binding
DFR86_RS22310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DFR86_RS22315	COG0651	ATP synthesis coupled electron transport
DFR86_RS22320	COG0650	Formate hydrogenlyase subunit 4
DFR86_RS22340	COG3842	ATPase activity
DFR86_RS22355	COG0730	response to heat
DFR86_RS22360	COG0813	purine-nucleoside phosphorylase activity
DFR86_RS22430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DFR86_RS22450	COG0667	Aldo Keto reductase
DFR86_RS22495	COG0123	including yeast histone deacetylase and acetoin utilization protein
DFR86_RS22520	COG2210	Belongs to the sulfur carrier protein TusA family
DFR86_RS22525	COG0425	Belongs to the sulfur carrier protein TusA family
DFR86_RS22540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DFR86_RS22555	COG2048	Heterodisulfide reductase, subunit B
DFR86_RS22570	COG0509	glycine decarboxylation via glycine cleavage system
DFR86_RS22590	COG2814	Major facilitator Superfamily
DFR86_RS22595	COG0095	Lipoate-protein ligase
DFR86_RS22605	COG0095	Lipoate-protein ligase
DFR86_RS22615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DFR86_RS22625	COG0450	alkyl hydroperoxide reductase
DFR86_RS22650	COG0509	glycine decarboxylation via glycine cleavage system
DFR86_RS22655	COG0095	Lipoate-protein ligase
DFR86_RS22675	COG0644	oxidoreductase
DFR86_RS22730	COG0475	glutathione-regulated potassium exporter activity
DFR86_RS22750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DFR86_RS22755	COG1305	Transglutaminase-like
DFR86_RS22775	COG0456	acetyltransferase
DFR86_RS22785	COG2217	Heavy metal translocating P-type atpase
DFR86_RS22790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DFR86_RS22790	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DFR86_RS22830	COG0425	Belongs to the sulfur carrier protein TusA family
DFR86_RS22845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DFR86_RS22845	COG0425	Belongs to the sulfur carrier protein TusA family
DFR86_RS22905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DFR86_RS22915	COG0805	protein transport
DFR86_RS22935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DFR86_RS22945	COG0277	FAD linked oxidase domain protein
DFR86_RS22960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DFR86_RS22980	COG0674	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS22985	COG1013	pyruvate-flavodoxin oxidoreductase activity
DFR86_RS22995	COG0535	radical SAM domain protein
DFR86_RS23040	COG1271	oxidase subunit
DFR86_RS23060	COG0531	amino acid
DFR86_RS23070	COG1960	acyl-CoA dehydrogenase activity
DFR86_RS23080	COG1960	acyl-CoA dehydrogenase activity
DFR86_RS23085	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DFR86_RS23130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DFR86_RS23140	COG2878	Part of a membrane complex involved in electron transport
DFR86_RS23290	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DFR86_RS23395	COG1337	RAMP superfamily