locus-tag	class	description
C4901_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C4901_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C4901_RS00035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C4901_RS00040	COG2022	thiamine diphosphate biosynthetic process
C4901_RS00110	COG1194	a g-specific adenine glycosylase
C4901_RS00115	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4901_RS00120	COG0412	Dienelactone hydrolase
C4901_RS00165	COG3008	intermembrane lipid transfer
C4901_RS00170	COG2995	paraquat-inducible protein a
C4901_RS00175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4901_RS00180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4901_RS00185	COG1845	cytochrome c oxidase, subunit III
C4901_RS00205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4901_RS00215	COG1011	Hydrolase
C4901_RS00245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C4901_RS00250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4901_RS00265	COG1519	Transferase
C4901_RS00270	COG0859	PFAM glycosyl transferase family 9
C4901_RS00330	COG0438	transferase activity, transferring glycosyl groups
C4901_RS00335	COG0859	PFAM glycosyl transferase family 9
C4901_RS00390	COG0572	uridine kinase
C4901_RS00395	COG0859	PFAM glycosyl transferase family 9
C4901_RS00415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C4901_RS00430	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C4901_RS00435	COG1850	ribulose-bisphosphate carboxylase activity
C4901_RS00440	COG0235	Class ii aldolase
C4901_RS00495	COG0408	coproporphyrinogen oxidase activity
C4901_RS00500	COG0151	Belongs to the GarS family
C4901_RS00505	COG0138	bifunctional purine biosynthesis protein purh
C4901_RS00510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C4901_RS00525	COG2264	protein methyltransferase activity
C4901_RS00530	COG0439	Biotin carboxylase
C4901_RS00535	COG0511	ligase activity, forming carbon-carbon bonds
C4901_RS00540	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C4901_RS00545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4901_RS00550	COG4232	protein-disulfide reductase activity
C4901_RS00555	COG1324	tolerance protein
C4901_RS00565	COG3030	protein affecting phage T7 exclusion by the F plasmid
C4901_RS00570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C4901_RS00575	COG0459	protein refolding
C4901_RS00585	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C4901_RS00585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C4901_RS00590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4901_RS00600	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_RS00660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C4901_RS00670	COG0352	thiamine-phosphate diphosphorylase activity
C4901_RS00675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C4901_RS00705	COG2967	ApaG domain
C4901_RS00710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4901_RS00720	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C4901_RS00725	COG1217	gtp-binding protein TYPA
C4901_RS00760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C4901_RS00765	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C4901_RS00770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C4901_RS00775	COG0037	tRNA processing
C4901_RS00780	COG1560	Kdo2-lipid A biosynthetic process
C4901_RS00790	COG1560	Kdo2-lipid A biosynthetic process
C4901_RS00805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C4901_RS00810	COG0242	peptide deformylase activity
C4901_RS00820	COG2922	Belongs to the Smg family
C4901_RS00830	COG4232	protein-disulfide reductase activity
C4901_RS00840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4901_RS00845	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C4901_RS00855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4901_RS00865	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C4901_RS00870	COG4942	peptidase
C4901_RS00875	COG0793	Belongs to the peptidase S41A family
C4901_RS00890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C4901_RS00905	COG2226	methyltransferase
C4901_RS00915	COG0745	RESPONSE REGULATOR receiver
C4901_RS00940	COG2188	Transcriptional regulator
C4901_RS00950	COG2188	Transcriptional regulator
C4901_RS00975	COG0493	'glutamate synthase
C4901_RS00975	COG0543	2 iron, 2 sulfur cluster binding
C4901_RS00990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4901_RS01005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C4901_RS01010	COG0704	Plays a role in the regulation of phosphate uptake
C4901_RS01020	COG0563	adenylate kinase activity
C4901_RS01030	COG0205	6-phosphofructokinase activity
C4901_RS01040	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C4901_RS01060	COG2076	Multidrug Resistance protein
C4901_RS01065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4901_RS01085	COG0726	polysaccharide deacetylase
C4901_RS01090	COG1643	Atp-dependent helicase
C4901_RS01095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C4901_RS01120	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C4901_RS01130	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C4901_RS01135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4901_RS01140	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C4901_RS01145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C4901_RS01160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4901_RS01180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C4901_RS01185	COG0482	sulfurtransferase activity
C4901_RS01200	COG0174	glutamine synthetase
C4901_RS01210	COG2706	6-phosphogluconolactonase activity
C4901_RS01275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4901_RS01275	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4901_RS01285	COG1242	4 iron, 4 sulfur cluster binding
C4901_RS01290	COG0826	peptidase U32
C4901_RS01295	COG0826	peptidase U32
C4901_RS01340	COG2070	2-Nitropropane dioxygenase
C4901_RS01350	COG1272	protein, Hemolysin III
C4901_RS01375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C4901_RS01380	COG0321	lipoyl(octanoyl) transferase activity
C4901_RS01405	COG2921	Belongs to the UPF0250 family
C4901_RS01420	COG0772	Belongs to the SEDS family
C4901_RS01425	COG0768	penicillin binding
C4901_RS01430	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C4901_RS01435	COG1792	Involved in formation and maintenance of cell shape
C4901_RS01440	COG1077	Cell shape determining protein MreB Mrl
C4901_RS01445	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4901_RS01450	COG0154	amidase activity
C4901_RS01455	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C4901_RS01500	COG2226	methyltransferase
C4901_RS01540	COG1233	COG1233 Phytoene dehydrogenase and related
C4901_RS01555	COG2048	Heterodisulfide reductase, subunit B
C4901_RS01580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C4901_RS01595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C4901_RS01600	COG1914	H( )-stimulated, divalent metal cation uptake system
C4901_RS01605	COG3852	Histidine kinase
C4901_RS01610	COG2204	response regulator
C4901_RS01625	COG1127	ABC transporter
C4901_RS01630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4901_RS01635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4901_RS01640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C4901_RS01645	COG0006	proline dipeptidase activity
C4901_RS01665	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C4901_RS01670	COG1692	metallophosphoesterase
C4901_RS01690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C4901_RS01710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C4901_RS01715	COG0604	alcohol dehydrogenase
C4901_RS01755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4901_RS01760	COG1459	type II secretion system
C4901_RS01785	COG3267	Type II secretory pathway component ExeA
C4901_RS01785	COG3409	Peptidoglycan-binding domain 1 protein
C4901_RS01800	COG0156	8-amino-7-oxononanoate synthase activity
C4901_RS01810	COG2226	methyltransferase
C4901_RS01865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4901_RS01885	COG2177	Part of the ABC transporter FtsEX involved in
C4901_RS01890	COG2884	Cell division ATP-binding protein ftsE
C4901_RS01895	COG0552	protein localization to endoplasmic reticulum
C4901_RS01900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4901_RS01905	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C4901_RS01910	COG0742	ribosomal rna small subunit methyltransferase
C4901_RS01925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C4901_RS01945	COG1131	(ABC) transporter
C4901_RS01950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C4901_RS01950	COG0543	2 iron, 2 sulfur cluster binding
C4901_RS02075	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
C4901_RS02080	COG1518	maintenance of DNA repeat elements
C4901_RS02155	COG3071	HemY protein
C4901_RS02170	COG0181	hydroxymethylbilane synthase activity
C4901_RS02190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C4901_RS02200	COG0477	Major facilitator Superfamily
C4901_RS02205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4901_RS02210	COG0730	response to heat
C4901_RS02220	COG0165	Argininosuccinate lyase
C4901_RS02225	COG3275	phosphorelay sensor kinase activity
C4901_RS02245	COG1335	isochorismatase
C4901_RS02255	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C4901_RS02280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4901_RS02290	COG1965	Belongs to the frataxin family
C4901_RS02305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C4901_RS02315	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C4901_RS02330	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C4901_RS02335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4901_RS02350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4901_RS02360	COG1309	transcriptional regulator
C4901_RS02380	COG2890	protein-(glutamine-N5) methyltransferase activity
C4901_RS02385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C4901_RS02390	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C4901_RS02405	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C4901_RS02410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C4901_RS02420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C4901_RS02425	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C4901_RS02430	COG0193	aminoacyl-tRNA hydrolase activity
C4901_RS02435	COG0012	GTP binding
C4901_RS02480	COG3093	addiction module antidote protein HigA
C4901_RS02515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4901_RS02550	COG2308	Evidence 4 Homologs of previously reported genes of
C4901_RS02575	COG1993	acr, cog1993
C4901_RS02580	COG0651	ATP synthesis coupled electron transport
C4901_RS02585	COG3260	NADH ubiquinone oxidoreductase 20
C4901_RS02590	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4901_RS02590	COG0649	NAD binding
C4901_RS02595	COG0651	ATP synthesis coupled electron transport
C4901_RS02605	COG0650	Formate hydrogenlyase subunit 4
C4901_RS02625	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C4901_RS02650	COG3118	belongs to the thioredoxin family
C4901_RS02655	COG1295	ribonuclease BN
C4901_RS02660	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C4901_RS02680	COG0545	Peptidyl-prolyl cis-trans isomerase
C4901_RS02685	COG1278	Cold shock
C4901_RS02695	COG0277	FAD linked oxidase domain protein
C4901_RS02700	COG0277	FAD linked oxidase domain protein
C4901_RS02705	COG0247	lactate metabolic process
C4901_RS02720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4901_RS02725	COG1702	phosphate starvation-inducible protein PhoH
C4901_RS02730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C4901_RS02735	COG4535	Mg2 and Co2 transporter CorC
C4901_RS02740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C4901_RS02815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4901_RS02835	COG0495	leucyl-tRNA aminoacylation
C4901_RS02840	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
C4901_RS02850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C4901_RS02855	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C4901_RS02865	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C4901_RS02870	COG0424	maF-like protein
C4901_RS02885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4901_RS02890	COG0312	modulator of DNA gyrase
C4901_RS02895	COG0312	modulator of DNA gyrase
C4901_RS02905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4901_RS02965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4901_RS02970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C4901_RS02980	COG1660	Displays ATPase and GTPase activities
C4901_RS02985	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C4901_RS03000	COG1137	ATPase activity
C4901_RS03015	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C4901_RS03030	COG1131	(ABC) transporter
C4901_RS03090	COG1127	ABC transporter
C4901_RS03095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C4901_RS03100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C4901_RS03115	COG1131	(ABC) transporter
C4901_RS03120	COG0842	Transport permease protein
C4901_RS03125	COG0271	Belongs to the BolA IbaG family
C4901_RS03130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C4901_RS03135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C4901_RS03140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C4901_RS03145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C4901_RS03150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4901_RS03155	COG0131	Imidazoleglycerol-phosphate dehydratase
C4901_RS03160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4901_RS03165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C4901_RS03170	COG0107	imidazoleglycerol-phosphate synthase activity
C4901_RS03180	COG0140	phosphoribosyl-ATP diphosphatase activity
C4901_RS03190	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4901_RS03195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C4901_RS03205	COG0477	Major facilitator Superfamily
C4901_RS03210	COG0438	transferase activity, transferring glycosyl groups
C4901_RS03220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4901_RS03225	COG0625	glutathione transferase activity
C4901_RS03260	COG0277	FAD linked oxidase domain protein
C4901_RS03265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4901_RS03275	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C4901_RS03300	COG2863	cytochrome
C4901_RS03305	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_RS03315	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4901_RS03320	COG2857	Cytochrome c1
C4901_RS03325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4901_RS03330	COG0148	phosphopyruvate hydratase activity
C4901_RS03355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C4901_RS03365	COG2001	Belongs to the MraZ family
C4901_RS03370	COG0275	rRNA processing
C4901_RS03385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C4901_RS03390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C4901_RS03395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4901_RS03400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C4901_RS03405	COG0772	Belongs to the SEDS family
C4901_RS03410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C4901_RS03415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4901_RS03420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4901_RS03425	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4901_RS03430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C4901_RS03440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C4901_RS03445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C4901_RS03455	COG0739	heme binding
C4901_RS03460	COG0653	protein targeting
C4901_RS03465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C4901_RS03470	COG0494	nUDIX hydrolase
C4901_RS03555	COG2204	response regulator
C4901_RS03585	COG0039	L-malate dehydrogenase activity
C4901_RS03595	COG0237	dephospho-CoA kinase activity
C4901_RS03600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C4901_RS03610	COG1592	Rubrerythrin
C4901_RS03660	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4901_RS03665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4901_RS03675	COG3547	Transposase (IS116 IS110 IS902 family)
C4901_RS03730	COG4584	PFAM Integrase catalytic
C4901_RS03735	COG2885	chlorophyll binding
C4901_RS03735	COG3047	cAMP biosynthetic process
C4901_RS03740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C4901_RS03745	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C4901_RS03750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C4901_RS03755	COG0784	Response regulator, receiver
C4901_RS03755	COG2198	Histidine kinase
C4901_RS03755	COG2205	protein histidine kinase activity
C4901_RS03760	COG3852	Histidine kinase
C4901_RS03775	COG2201	protein-glutamate methylesterase activity
C4901_RS03780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C4901_RS03785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C4901_RS03785	COG0047	phosphoribosylformylglycinamidine synthase activity
C4901_RS03800	COG0509	glycine decarboxylation via glycine cleavage system
C4901_RS03830	COG5265	(ABC) transporter
C4901_RS03835	COG0488	(ABC) transporter
C4901_RS03845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C4901_RS03850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C4901_RS03855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4901_RS03860	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C4901_RS03865	COG0022	dehydrogenase e1 component
C4901_RS03865	COG0508	dehydrogenase complex catalyzes the overall conversion of
C4901_RS03870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4901_RS03875	COG0137	argininosuccinate synthase activity
C4901_RS03880	COG3852	Histidine kinase
C4901_RS03905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C4901_RS03920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4901_RS03965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4901_RS03965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4901_RS03985	COG0717	Belongs to the dCTP deaminase family
C4901_RS04025	COG0756	dUTP diphosphatase activity
C4901_RS04030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C4901_RS04035	COG2003	Belongs to the UPF0758 family
C4901_RS04045	COG3383	formate dehydrogenase (NAD+) activity
C4901_RS04050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C4901_RS04055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C4901_RS04090	COG1595	DNA-templated transcription, initiation
C4901_RS04095	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C4901_RS04100	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C4901_RS04105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C4901_RS04110	COG0628	permease
C4901_RS04125	COG1027	Aspartate ammonia-lyase
C4901_RS04135	COG0500	methyltransferase
C4901_RS04165	COG2201	protein-glutamate methylesterase activity
C4901_RS04175	COG0477	Major facilitator Superfamily
C4901_RS04185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4901_RS04185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4901_RS04190	COG1902	pentaerythritol trinitrate reductase activity
C4901_RS04195	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C4901_RS04200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C4901_RS04205	COG1509	lysine 2,3-aminomutase activity
C4901_RS04215	COG0450	alkyl hydroperoxide reductase
C4901_RS04220	COG1254	Belongs to the acylphosphatase family
C4901_RS04235	COG0442	prolyl-tRNA aminoacylation
C4901_RS04250	COG2433	Pfam Transposase IS66
C4901_RS04285	COG1940	carbohydrate kinase activity
C4901_RS04290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C4901_RS04295	COG2814	Major facilitator Superfamily
C4901_RS04305	COG1566	PFAM secretion protein HlyD family protein
C4901_RS04315	COG1469	GTP cyclohydrolase I activity
C4901_RS04320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C4901_RS04325	COG0142	geranyltranstransferase activity
C4901_RS04330	COG1722	exodeoxyribonuclease VII activity
C4901_RS04340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C4901_RS04385	COG1487	ribonuclease activity
C4901_RS04405	COG0656	L-ascorbic acid biosynthetic process
C4901_RS04410	COG0667	Aldo Keto reductase
C4901_RS04425	COG1064	alcohol dehydrogenase
C4901_RS04440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C4901_RS04450	COG2867	negative regulation of translational initiation
C4901_RS04460	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4901_RS04470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C4901_RS04470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C4901_RS04475	COG0497	DNA recombination
C4901_RS04480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C4901_RS04485	COG1420	regulation of RNA biosynthetic process
C4901_RS04490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C4901_RS04495	COG0443	Heat shock 70 kDa protein
C4901_RS04500	COG0484	heat shock protein binding
C4901_RS04510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C4901_RS04515	COG0505	Belongs to the CarA family
C4901_RS04520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C4901_RS04525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C4901_RS04535	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C4901_RS04545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C4901_RS04550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C4901_RS04555	COG0149	triose-phosphate isomerase activity
C4901_RS04570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4901_RS04575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4901_RS04580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4901_RS04585	COG0649	NAD binding
C4901_RS04590	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C4901_RS04600	COG1034	ATP synthesis coupled electron transport
C4901_RS04600	COG1034	ATP synthesis coupled electron transport
C4901_RS04605	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C4901_RS04610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C4901_RS04620	COG0713	ATP synthesis coupled electron transport
C4901_RS04635	COG1007	ATP synthesis coupled electron transport
C4901_RS04670	COG0779	Required for maturation of 30S ribosomal subunits
C4901_RS04675	COG0195	Participates in both transcription termination and antitermination
C4901_RS04675	COG2251	uridine kinase activity
C4901_RS04680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C4901_RS04685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C4901_RS04695	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C4901_RS04700	COG1185	polyribonucleotide nucleotidyltransferase activity
C4901_RS04715	COG0429	hydrolase of the alpha beta-hydrolase fold
C4901_RS04720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C4901_RS04725	COG0586	Pfam SNARE associated Golgi protein
C4901_RS04730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C4901_RS04735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C4901_RS04740	COG0720	synthase
C4901_RS04745	COG0546	phosphoglycolate phosphatase activity
C4901_RS04750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4901_RS04755	COG0402	S-adenosylhomocysteine deaminase activity
C4901_RS04765	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C4901_RS04770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4901_RS04775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4901_RS04780	COG1845	cytochrome c oxidase, subunit III
C4901_RS04800	COG0730	response to heat
C4901_RS04810	COG3387	PFAM Glycoside hydrolase 15-related
C4901_RS04865	COG3852	Histidine kinase
C4901_RS04925	COG2944	sequence-specific DNA binding
C4901_RS04930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C4901_RS04940	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C4901_RS04950	COG1064	alcohol dehydrogenase
C4901_RS04990	COG2165	general secretion pathway protein
C4901_RS05040	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C4901_RS05045	COG0543	2 iron, 2 sulfur cluster binding
C4901_RS05045	COG0493	'glutamate synthase
C4901_RS05130	COG0142	geranyltranstransferase activity
C4901_RS05135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C4901_RS05140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C4901_RS05145	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C4901_RS05150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C4901_RS05155	COG0268	Binds directly to 16S ribosomal RNA
C4901_RS05170	COG0196	riboflavin kinase activity
C4901_RS05175	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C4901_RS05185	COG1047	Peptidyl-prolyl cis-trans
C4901_RS05190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4901_RS05265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C4901_RS05285	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C4901_RS05300	COG0330	HflC and HflK could
C4901_RS05335	COG3547	Transposase (IS116 IS110 IS902 family)
C4901_RS05350	COG1902	pentaerythritol trinitrate reductase activity
C4901_RS05355	COG0386	Belongs to the glutathione peroxidase family
C4901_RS05370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C4901_RS05375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4901_RS05380	COG1215	transferase activity, transferring glycosyl groups
C4901_RS05390	COG2853	Lipoprotein
C4901_RS05395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4901_RS05410	COG3394	polysaccharide catabolic process
C4901_RS05430	COG1657	PFAM Prenyltransferase squalene oxidase
C4901_RS05480	COG0625	glutathione transferase activity
C4901_RS05490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4901_RS05495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C4901_RS05500	COG1845	cytochrome c oxidase, subunit III
C4901_RS05515	COG2192	nodulation
C4901_RS05555	COG0436	Aminotransferase
C4901_RS05580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C4901_RS05585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C4901_RS05590	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C4901_RS05595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C4901_RS05600	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C4901_RS05605	COG0072	phenylalanine-tRNA ligase activity
C4901_RS05605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C4901_RS05610	COG0776	regulation of translation
C4901_RS05625	COG0625	glutathione transferase activity
C4901_RS05635	COG0004	ammonium transporteR
C4901_RS05640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C4901_RS05710	COG2200	EAL domain
C4901_RS05710	COG2199	diguanylate cyclase activity
C4901_RS05755	COG0859	PFAM glycosyl transferase family 9
C4901_RS05780	COG0326	Molecular chaperone. Has ATPase activity
C4901_RS05785	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C4901_RS05795	COG0544	peptidyl-prolyl cis-trans isomerase activity
C4901_RS05800	COG0740	serine-type endopeptidase activity
C4901_RS05810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4901_RS05825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C4901_RS05835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4901_RS05845	COG0741	lytic transglycosylase activity
C4901_RS05845	COG1388	LysM domain
C4901_RS05850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C4901_RS05855	COG2226	methyltransferase
C4901_RS05860	COG0328	RNA-DNA hybrid ribonuclease activity
C4901_RS05865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C4901_RS05890	COG1648	precorrin-2 dehydrogenase activity
C4901_RS05890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4901_RS05895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4901_RS05900	COG2146	nitrite reductase [NAD(P)H] activity
C4901_RS05905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4901_RS05910	COG0670	Belongs to the BI1 family
C4901_RS05920	COG0297	glycogen (starch) synthase activity
C4901_RS05935	COG0837	glucose binding
C4901_RS05940	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C4901_RS05945	COG0166	Belongs to the GPI family
C4901_RS05950	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C4901_RS05990	COG2204	response regulator
C4901_RS05995	COG0058	SHG alpha-glucan phosphorylase activity
C4901_RS06000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4901_RS06030	COG3284	Transcriptional regulator
C4901_RS06035	COG2204	response regulator
C4901_RS06055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4901_RS06060	COG0366	Alpha amylase catalytic
C4901_RS06080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C4901_RS06115	COG1104	cysteine desulfurase activity
C4901_RS06140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4901_RS06150	COG1845	cytochrome c oxidase, subunit III
C4901_RS06165	COG0109	protoheme IX farnesyltransferase activity
C4901_RS06175	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4901_RS06185	COG2084	Dehydrogenase
C4901_RS06190	COG3158	transport of potassium into the cell
C4901_RS06210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4901_RS06210	COG0574	Belongs to the PEP-utilizing enzyme family
C4901_RS06225	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4901_RS06240	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C4901_RS06250	COG0784	Response regulator, receiver
C4901_RS06250	COG5002	protein histidine kinase activity
C4901_RS06250	COG2198	Histidine kinase
C4901_RS06325	COG3546	catalase activity
C4901_RS06330	COG1914	H( )-stimulated, divalent metal cation uptake system
C4901_RS06370	COG0778	Nitroreductase
C4901_RS06385	COG1733	regulation of RNA biosynthetic process
C4901_RS06425	COG3012	SEC-C Motif Domain Protein
C4901_RS06430	COG0515	serine threonine protein kinase
C4901_RS06435	COG0531	amino acid
C4901_RS06440	COG0069	glutamate synthase activity
C4901_RS06450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C4901_RS06455	COG0174	glutamine synthetase
C4901_RS06465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4901_RS06465	COG0446	pyridine nucleotide-disulphide oxidoreductase
C4901_RS06555	COG3609	addiction module antidote protein, CC2985 family
C4901_RS06590	COG0438	transferase activity, transferring glycosyl groups
C4901_RS06590	COG1216	Glycosyl transferase, family 2
C4901_RS06595	COG3550	peptidyl-serine autophosphorylation
C4901_RS06610	COG1396	sequence-specific DNA binding
C4901_RS06695	COG0438	transferase activity, transferring glycosyl groups
C4901_RS06700	COG0438	transferase activity, transferring glycosyl groups
C4901_RS06710	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C4901_RS06720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C4901_RS06725	COG0438	transferase activity, transferring glycosyl groups
C4901_RS06790	COG2221	Nitrite and sulphite reductase 4Fe-4S
C4901_RS06795	COG2221	Nitrite and sulphite reductase 4Fe-4S
C4901_RS06800	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C4901_RS06805	COG2923	Belongs to the DsrF TusC family
C4901_RS06815	COG2920	part of a sulfur-relay system
C4901_RS06850	COG1797	cobyrinic acid a,c-diamide synthase activity
C4901_RS06855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C4901_RS06865	COG2197	response regulator
C4901_RS06870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C4901_RS06890	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C4901_RS06905	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C4901_RS06930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C4901_RS06930	COG1648	precorrin-2 dehydrogenase activity
C4901_RS06940	COG2003	Belongs to the UPF0758 family
C4901_RS06990	COG4942	peptidase
C4901_RS07010	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4901_RS07015	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4901_RS07030	COG1403	HNH endonuclease
C4901_RS07035	COG1278	Cold shock
C4901_RS07040	COG3416	Protein conserved in bacteria
C4901_RS07040	COG2943	transferase activity, transferring hexosyl groups
C4901_RS07045	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
C4901_RS07065	COG0513	Belongs to the DEAD box helicase family
C4901_RS07075	COG3344	reverse transcriptase
C4901_RS07090	COG1968	undecaprenyl-diphosphatase activity
C4901_RS07095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C4901_RS07115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4901_RS07120	COG0481	GTPase activity
C4901_RS07135	COG0571	ribonuclease III activity
C4901_RS07140	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C4901_RS07145	COG1381	Involved in DNA repair and RecF pathway recombination
C4901_RS07165	COG3609	addiction module antidote protein, CC2985 family
C4901_RS07170	COG0736	holo-[acyl-carrier-protein] synthase activity
C4901_RS07185	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C4901_RS07190	COG0316	Belongs to the HesB IscA family
C4901_RS07195	COG1181	Belongs to the D-alanine--D-alanine ligase family
C4901_RS07220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C4901_RS07255	COG0488	(ABC) transporter
C4901_RS07260	COG0625	glutathione transferase activity
C4901_RS07275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4901_RS07300	COG0475	glutathione-regulated potassium exporter activity
C4901_RS07450	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4901_RS07500	COG1484	DNA-dependent DNA replication
C4901_RS07525	COG2801	Transposase and inactivated derivatives
C4901_RS07565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C4901_RS07565	COG0574	Belongs to the PEP-utilizing enzyme family
C4901_RS07570	COG1131	(ABC) transporter
C4901_RS07640	COG1047	Peptidyl-prolyl cis-trans
C4901_RS07680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4901_RS07715	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C4901_RS07720	COG3226	Transcriptional regulator
C4901_RS07725	COG1741	Belongs to the pirin family
C4901_RS07730	COG0655	NAD(P)H dehydrogenase (quinone) activity
C4901_RS07735	COG1733	regulation of RNA biosynthetic process
C4901_RS07740	COG1322	Protein conserved in bacteria
C4901_RS07745	COG0488	(ABC) transporter
C4901_RS07750	COG0726	polysaccharide deacetylase
C4901_RS07785	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4901_RS07800	COG1064	alcohol dehydrogenase
C4901_RS07805	COG2197	response regulator
C4901_RS07830	COG2346	COG2346, Truncated hemoglobins
C4901_RS07835	COG1959	2 iron, 2 sulfur cluster binding
C4901_RS07865	COG0277	FAD linked oxidase domain protein
C4901_RS07870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C4901_RS07875	COG2733	membrane
C4901_RS07885	COG1280	lysine exporter protein (LysE YggA)
C4901_RS07895	COG3023	N-Acetylmuramoyl-L-alanine amidase
C4901_RS07900	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C4901_RS07910	COG0494	nUDIX hydrolase
C4901_RS07930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4901_RS07935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4901_RS07940	COG1538	Outer membrane efflux protein
C4901_RS07945	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C4901_RS07950	COG0589	response to stress
C4901_RS07970	COG1070	Carbohydrate kinase
C4901_RS07975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C4901_RS07980	COG1196	nuclear chromosome segregation
C4901_RS07985	COG3115	cell septum assembly
C4901_RS07990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C4901_RS07995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C4901_RS08005	COG2350	Protein conserved in bacteria
C4901_RS08015	COG0613	PHP domain protein
C4901_RS08020	COG0009	L-threonylcarbamoyladenylate synthase
C4901_RS08025	COG1994	Peptidase M50
C4901_RS08030	COG0180	Tryptophanyl-tRNA synthetase
C4901_RS08035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C4901_RS08050	COG1187	pseudouridine synthase activity
C4901_RS08065	COG0228	four-way junction DNA binding
C4901_RS08070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C4901_RS08075	COG0336	Belongs to the RNA methyltransferase TrmD family
C4901_RS08080	COG0335	large ribosomal subunit rRNA binding
C4901_RS08100	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C4901_RS08115	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C4901_RS08120	COG0668	transmembrane transport
C4901_RS08130	COG2027	D-alanyl-D-alanine carboxypeptidase
C4901_RS08135	COG0372	Belongs to the citrate synthase family
C4901_RS08140	COG1605	Chorismate mutase
C4901_RS08140	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C4901_RS08150	COG0586	Pfam SNARE associated Golgi protein
C4901_RS08180	COG0675	Transposase, IS605 OrfB family
C4901_RS08190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C4901_RS08190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4901_RS08195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4901_RS08200	COG2957	Belongs to the agmatine deiminase family
C4901_RS08235	COG0167	dihydroorotate dehydrogenase activity
C4901_RS08240	COG1187	pseudouridine synthase activity
C4901_RS08245	COG0129	dihydroxy-acid dehydratase activity
C4901_RS08255	COG3568	Endonuclease Exonuclease Phosphatase
C4901_RS08260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C4901_RS08270	COG0789	Transcriptional regulator
C4901_RS08290	COG0482	sulfurtransferase activity
C4901_RS08325	COG1278	Cold shock
C4901_RS08330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C4901_RS08335	COG0542	response to heat
C4901_RS08345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C4901_RS08350	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C4901_RS08355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C4901_RS08375	COG0045	succinate-CoA ligase (ADP-forming) activity
C4901_RS08380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C4901_RS08385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C4901_RS08390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C4901_RS08390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4901_RS08410	COG0693	protein deglycase activity
C4901_RS08420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C4901_RS08440	COG2095	MarC family integral membrane protein
C4901_RS08445	COG0542	response to heat
C4901_RS08460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C4901_RS08465	COG2814	Major facilitator Superfamily
C4901_RS08475	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C4901_RS08480	COG0066	3-isopropylmalate dehydratase activity
C4901_RS08485	COG0473	3-isopropylmalate dehydrogenase activity
C4901_RS08490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C4901_RS08505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C4901_RS08520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C4901_RS08610	COG0768	penicillin binding
C4901_RS08620	COG0583	DNA-binding transcription factor activity
C4901_RS08630	COG3706	GGDEF domain
C4901_RS08630	COG2203	Gaf domain
C4901_RS08630	COG5001	Diguanylate cyclase
C4901_RS08630	COG4251	negative regulation of phosphorylation
C4901_RS08635	COG3260	NADH ubiquinone oxidoreductase 20
C4901_RS08640	COG0649	NAD binding
C4901_RS08645	COG0651	ATP synthesis coupled electron transport
C4901_RS08655	COG0650	Formate hydrogenlyase subunit 4
C4901_RS08700	COG0330	HflC and HflK could
C4901_RS08710	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C4901_RS08715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C4901_RS08725	COG0557	exoribonuclease II activity
C4901_RS08730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C4901_RS08735	COG0360	Binds together with S18 to 16S ribosomal RNA
C4901_RS08740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C4901_RS08750	COG0305	Participates in initiation and elongation during chromosome replication
C4901_RS08755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C4901_RS08765	COG5001	Diguanylate cyclase
C4901_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_RS08795	COG2855	membrane
C4901_RS08800	COG2116	formate transmembrane transporter activity
C4901_RS08810	COG0028	Belongs to the TPP enzyme family
C4901_RS08820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C4901_RS08825	COG0424	maF-like protein
C4901_RS08830	COG5016	pyruvate
C4901_RS08830	COG0511	ligase activity, forming carbon-carbon bonds
C4901_RS08835	COG0439	Biotin carboxylase
C4901_RS08850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C4901_RS08855	COG0416	fatty acid biosynthetic process
C4901_RS08860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C4901_RS08865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C4901_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_RS08875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4901_RS08880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C4901_RS08885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4901_RS08890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C4901_RS08895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C4901_RS08900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C4901_RS08915	COG0084	hydrolase, TatD family'
C4901_RS08965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4901_RS08995	COG2192	nodulation
C4901_RS09000	COG0859	PFAM glycosyl transferase family 9
C4901_RS09005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C4901_RS09010	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_RS09015	COG0438	transferase activity, transferring glycosyl groups
C4901_RS09020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C4901_RS09035	COG2890	protein-(glutamine-N5) methyltransferase activity
C4901_RS09045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4901_RS09250	COG0732	type I restriction modification DNA specificity domain
C4901_RS09295	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4901_RS09390	COG1432	Conserved Protein
C4901_RS09445	COG0322	excinuclease ABC activity
C4901_RS09450	COG1573	uracil-dna glycosylase
C4901_RS09455	COG1472	Belongs to the glycosyl hydrolase 3 family
C4901_RS09460	COG1376	ErfK ybiS ycfS ynhG family protein
C4901_RS09465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C4901_RS09480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C4901_RS09485	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
C4901_RS09490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C4901_RS09500	COG0436	Aminotransferase
C4901_RS09520	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C4901_RS09525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C4901_RS09530	COG0616	signal peptide processing
C4901_RS09540	COG0546	phosphoglycolate phosphatase activity
C4901_RS09560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4901_RS09565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C4901_RS09575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C4901_RS09580	COG2835	tetraacyldisaccharide 4'-kinase activity
C4901_RS09585	COG1663	tetraacyldisaccharide 4'-kinase activity
C4901_RS09595	COG1132	(ABC) transporter
C4901_RS09605	COG0811	peptide transport
C4901_RS09610	COG1136	(ABC) transporter
C4901_RS09615	COG4591	ABC-type transport system involved in lipoprotein release permease component
C4901_RS09625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C4901_RS09640	COG2171	N-acyltransferase activity
C4901_RS09645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C4901_RS09650	COG1716	ATPase activity
C4901_RS09680	COG1218	3'(2'),5'-bisphosphate nucleotidase
C4901_RS09700	COG0675	Transposase, IS605 OrfB family
C4901_RS09705	COG2226	methyltransferase
C4901_RS09710	COG0179	Fumarylacetoacetate (FAA) hydrolase
C4901_RS09715	COG0243	molybdopterin cofactor binding
C4901_RS09720	COG0437	4 iron, 4 sulfur cluster binding
C4901_RS09725	COG3302	dmso reductase anchor subunit
C4901_RS09730	COG0315	cyclic pyranopterin monophosphate synthase activity
C4901_RS09740	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C4901_RS09745	COG0314	molybdopterin synthase activity
C4901_RS09750	COG0488	(ABC) transporter
C4901_RS09765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C4901_RS09800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C4901_RS09855	COG2378	regulation of single-species biofilm formation
C4901_RS09865	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_RS09880	COG1252	NADH dehydrogenase
C4901_RS09910	COG1566	PFAM secretion protein HlyD family protein
C4901_RS09935	COG2217	Heavy metal translocating P-type atpase
C4901_RS09940	COG2217	Heavy metal translocating P-type atpase
C4901_RS09970	COG0678	peroxiredoxin activity
C4901_RS09970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C4901_RS09980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4901_RS09985	COG2719	SpoVR family
C4901_RS09990	COG2718	Belongs to the UPF0229 family
C4901_RS09995	COG2766	serine protein kinase
C4901_RS10005	COG2223	nitrite transmembrane transporter activity
C4901_RS10030	COG0697	spore germination
C4901_RS10055	COG1741	Belongs to the pirin family
C4901_RS10065	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C4901_RS10080	COG3002	Belongs to the UPF0753 family
C4901_RS10090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4901_RS10115	COG2193	ferroxidase activity
C4901_RS10120	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C4901_RS10125	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C4901_RS10130	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C4901_RS10160	COG1850	ribulose-bisphosphate carboxylase activity
C4901_RS10170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C4901_RS10190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C4901_RS10195	COG1923	regulation of RNA biosynthetic process
C4901_RS10200	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C4901_RS10205	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C4901_RS10245	COG2814	Major facilitator Superfamily
C4901_RS10320	COG2814	Major facilitator Superfamily
C4901_RS10345	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C4901_RS10350	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C4901_RS10355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C4901_RS10360	COG1053	succinate dehydrogenase
C4901_RS10385	COG0148	phosphopyruvate hydratase activity
C4901_RS10390	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C4901_RS10395	COG0504	CTP synthase activity
C4901_RS10400	COG0037	tRNA processing
C4901_RS10405	COG0825	malonyl-CoA metabolic process
C4901_RS10410	COG0587	DNA-directed DNA polymerase activity
C4901_RS10415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C4901_RS10420	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4901_RS10430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C4901_RS10450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C4901_RS10455	COG0575	Belongs to the CDS family
C4901_RS10460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C4901_RS10470	COG0528	UMP kinase activity
C4901_RS10475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C4901_RS10480	COG0052	Belongs to the universal ribosomal protein uS2 family
C4901_RS10555	COG0531	amino acid
C4901_RS10560	COG0860	N-Acetylmuramoyl-L-alanine amidase
C4901_RS10565	COG0802	atpase or kinase
C4901_RS10570	COG0802	atpase or kinase
C4901_RS10575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C4901_RS10575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C4901_RS10580	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C4901_RS10585	COG2154	pterin-4-alpha-carbinolamine dehydratase
C4901_RS10590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C4901_RS10595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C4901_RS10630	COG3237	CsbD-like
C4901_RS10655	COG4566	intracellular signal transduction
C4901_RS10685	COG2205	protein histidine kinase activity
C4901_RS10695	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C4901_RS10735	COG4454	pyrroloquinoline quinone binding
C4901_RS10740	COG0109	protoheme IX farnesyltransferase activity
C4901_RS10760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C4901_RS10785	COG0653	protein targeting
C4901_RS10800	COG0517	IMP dehydrogenase activity
C4901_RS10805	COG4974	Belongs to the 'phage' integrase family
C4901_RS10810	COG0519	Catalyzes the synthesis of GMP from XMP
C4901_RS10810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C4901_RS10825	COG1570	exodeoxyribonuclease VII activity
C4901_RS10825	COG1570	exodeoxyribonuclease VII activity
C4901_RS10830	COG1160	GTP binding
C4901_RS10845	COG0124	histidyl-tRNA synthetase
C4901_RS10850	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C4901_RS10865	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C4901_RS10870	COG0105	UTP biosynthetic process
C4901_RS10885	COG0443	Heat shock 70 kDa protein
C4901_RS10890	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C4901_RS10895	COG0316	Belongs to the HesB IscA family
C4901_RS10900	COG0822	iron-sulfur transferase activity
C4901_RS10905	COG1104	cysteine desulfurase activity
C4901_RS10920	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C4901_RS10925	COG0483	inositol monophosphate 1-phosphatase activity
C4901_RS10945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C4901_RS10950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C4901_RS10955	COG4536	flavin adenine dinucleotide binding
C4901_RS10960	COG1193	negative regulation of DNA recombination
C4901_RS10965	COG1214	PFAM Peptidase M22, glycoprotease
C4901_RS10975	COG0667	Aldo Keto reductase
C4901_RS11010	COG1002	Type II restriction enzyme, methylase subunits
C4901_RS11015	COG1061	Type III restriction enzyme res subunit
C4901_RS11020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4901_RS11095	COG2944	sequence-specific DNA binding
C4901_RS11145	COG4372	Transposase
C4901_RS11170	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C4901_RS11250	COG3609	addiction module antidote protein, CC2985 family
C4901_RS11285	COG3158	transport of potassium into the cell
C4901_RS11320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C4901_RS11325	COG0527	aspartate kinase activity
C4901_RS11330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C4901_RS11335	COG2137	regulation of response to DNA damage stimulus
C4901_RS11340	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C4901_RS11350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C4901_RS11355	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C4901_RS11360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C4901_RS11375	COG2815	serine threonine protein kinase
C4901_RS11375	COG0515	serine threonine protein kinase
C4901_RS11390	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4901_RS11390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C4901_RS11395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4901_RS11400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C4901_RS11405	COG2703	oxygen carrier activity
C4901_RS11420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C4901_RS11425	COG1862	Preprotein translocase
C4901_RS11430	COG0343	queuine tRNA-ribosyltransferase activity
C4901_RS11440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C4901_RS11500	COG1061	Type III restriction enzyme res subunit
C4901_RS11505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C4901_RS11680	COG5001	Diguanylate cyclase
C4901_RS11755	COG2814	Major facilitator Superfamily
C4901_RS11760	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C4901_RS11765	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C4901_RS11770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C4901_RS11780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C4901_RS11785	COG0617	tRNA 3'-terminal CCA addition
C4901_RS11795	COG3118	belongs to the thioredoxin family
C4901_RS11825	COG0438	transferase activity, transferring glycosyl groups
C4901_RS11835	COG0463	Glycosyl transferase, family 2
C4901_RS11840	COG0297	glycogen (starch) synthase activity
C4901_RS11840	COG0438	transferase activity, transferring glycosyl groups
C4901_RS11845	COG0110	maltose O-acetyltransferase activity
C4901_RS11860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4901_RS11865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C4901_RS11870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C4901_RS11875	COG0318	PFAM AMP-dependent synthetase and ligase
C4901_RS11880	COG0367	asparagine synthase
C4901_RS11885	COG3267	Type II secretory pathway component ExeA
C4901_RS11885	COG3409	Peptidoglycan-binding domain 1 protein
C4901_RS11910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C4901_RS11920	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C4901_RS11925	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C4901_RS11930	COG1674	ftsk spoiiie
C4901_RS11935	COG0686	Belongs to the AlaDH PNT family
C4901_RS11940	COG0492	ferredoxin-NADP+ reductase activity
C4901_RS11950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C4901_RS11955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C4901_RS11965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C4901_RS11975	COG0242	peptide deformylase activity
C4901_RS11990	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C4901_RS12000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C4901_RS12010	COG4221	oxidoreductase activity
C4901_RS12025	COG1850	ribulose-bisphosphate carboxylase activity
C4901_RS12045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C4901_RS12060	COG1132	(ABC) transporter
C4901_RS12070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C4901_RS12075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4901_RS12075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4901_RS12080	COG0284	orotidine-5'-phosphate decarboxylase activity
C4901_RS12085	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C4901_RS12095	COG0776	regulation of translation
C4901_RS12100	COG0539	negative regulation of cytoplasmic translation
C4901_RS12105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C4901_RS12110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C4901_RS12115	COG0287	Prephenate dehydrogenase
C4901_RS12120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C4901_RS12130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C4901_RS12135	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C4901_RS12180	COG3436	PFAM IS66 Orf2 family protein
C4901_RS12245	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
C4901_RS12250	COG2204	response regulator
C4901_RS12270	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C4901_RS12280	COG0375	protein maturation
C4901_RS12300	COG0298	carbon dioxide binding
C4901_RS12360	COG2271	Major facilitator Superfamily
C4901_RS12370	COG5001	Diguanylate cyclase
C4901_RS12380	COG0418	dihydroorotase activity
C4901_RS12385	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C4901_RS12390	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C4901_RS12440	COG3384	dioxygenase
C4901_RS12445	COG1252	NADH dehydrogenase
C4901_RS12460	COG4451	ribulose bisphosphate carboxylase, small
C4901_RS12470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C4901_RS12475	COG0028	Belongs to the TPP enzyme family
C4901_RS12515	COG0746	molybdenum cofactor guanylyltransferase activity
C4901_RS12535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4901_RS12540	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C4901_RS12560	COG4133	protoheme IX ABC transporter activity
C4901_RS12570	COG3088	subunit of a heme lyase
C4901_RS12575	COG1138	Cytochrome C-type biogenesis protein
C4901_RS12590	COG0795	lipopolysaccharide-transporting ATPase activity
C4901_RS12595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C4901_RS12615	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4901_RS12625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C4901_RS12630	COG0456	acetyltransferase
C4901_RS12635	COG1573	uracil-dna glycosylase
C4901_RS12695	COG2920	part of a sulfur-relay system
C4901_RS12700	COG2827	Endonuclease containing a URI domain
C4901_RS12710	COG0587	DNA-directed DNA polymerase activity
C4901_RS12730	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_RS12730	COG0604	alcohol dehydrogenase
C4901_RS12730	COG3321	synthase
C4901_RS12750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4901_RS12765	COG1183	phosphatidylcholine synthase activity
C4901_RS12770	COG0688	phosphatidylethanolamine metabolic process
C4901_RS12775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C4901_RS12780	COG0440	acetolactate synthase activity
C4901_RS12785	COG0028	Belongs to the TPP enzyme family
C4901_RS12810	COG0215	cysteine-tRNA ligase activity
C4901_RS12815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C4901_RS12820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C4901_RS12825	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C4901_RS12855	COG0285	dihydrofolate synthase activity
C4901_RS12860	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C4901_RS12865	COG0159	tryptophan synthase activity
C4901_RS12870	COG0133	tryptophan synthase activity
C4901_RS12875	COG0135	phosphoribosylanthranilate isomerase activity
C4901_RS12890	COG0583	DNA-binding transcription factor activity
C4901_RS12940	COG0123	including yeast histone deacetylase and acetoin utilization protein
C4901_RS12985	COG0644	oxidoreductase
C4901_RS12990	COG0095	Lipoate-protein ligase
C4901_RS13000	COG0509	glycine decarboxylation via glycine cleavage system
C4901_RS13010	COG0509	glycine decarboxylation via glycine cleavage system
C4901_RS13015	COG2048	Heterodisulfide reductase, subunit B
C4901_RS13045	COG2210	Belongs to the sulfur carrier protein TusA family
C4901_RS13050	COG0425	Belongs to the sulfur carrier protein TusA family
C4901_RS13055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4901_RS13095	COG3258	Cytochrome c
C4901_RS13130	COG2095	MarC family integral membrane protein
C4901_RS13135	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C4901_RS13145	COG2204	response regulator
C4901_RS13155	COG2205	protein histidine kinase activity
C4901_RS13160	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4901_RS13165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C4901_RS13195	COG3547	Transposase (IS116 IS110 IS902 family)
C4901_RS13200	COG1450	Type ii and iii secretion system protein
C4901_RS13210	COG3547	Transposase (IS116 IS110 IS902 family)
C4901_RS13215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4901_RS13230	COG3436	PFAM IS66 Orf2 family protein
C4901_RS13240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C4901_RS13245	COG1459	type II secretion system
C4901_RS13275	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C4901_RS13285	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C4901_RS13305	COG2205	protein histidine kinase activity
C4901_RS13305	COG2202	Pas domain
C4901_RS13310	COG1408	metallophosphoesterase
C4901_RS13340	COG3706	GGDEF domain
C4901_RS13375	COG0811	peptide transport
C4901_RS13390	COG3608	succinylglutamate desuccinylase aspartoacylase
C4901_RS13390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C4901_RS13425	COG1335	isochorismatase
C4901_RS13430	COG0402	S-adenosylhomocysteine deaminase activity
C4901_RS13475	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C4901_RS13480	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C4901_RS13485	COG0295	cytidine deaminase activity
C4901_RS13510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C4901_RS13515	COG1309	transcriptional regulator
C4901_RS13520	COG2814	Major facilitator Superfamily
C4901_RS13540	COG0784	Response regulator, receiver
C4901_RS13550	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C4901_RS13565	COG1215	transferase activity, transferring glycosyl groups
C4901_RS13575	COG3436	PFAM IS66 Orf2 family protein
C4901_RS13650	COG3547	Transposase (IS116 IS110 IS902 family)
C4901_RS13680	COG3436	PFAM IS66 Orf2 family protein
C4901_RS13735	COG3436	PFAM IS66 Orf2 family protein
C4901_RS13825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C4901_RS13830	COG0602	queuosine metabolic process
C4901_RS13865	COG0824	Thioesterase
C4901_RS13870	COG2255	four-way junction helicase activity
C4901_RS13880	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C4901_RS13885	COG0217	transcriptional regulatory protein
C4901_RS13900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C4901_RS13925	COG3001	Fructosamine kinase
C4901_RS13930	COG0516	GMP reductase activity
C4901_RS13930	COG0517	IMP dehydrogenase activity
C4901_RS13950	COG1929	Belongs to the glycerate kinase type-1 family
C4901_RS13965	COG1960	acyl-CoA dehydrogenase activity
C4901_RS13970	COG3258	Cytochrome c
C4901_RS13985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C4901_RS14030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C4901_RS14045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C4901_RS14045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C4901_RS14050	COG0859	PFAM glycosyl transferase family 9
C4901_RS14060	COG0202	RNA polymerase activity
C4901_RS14065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C4901_RS14070	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C4901_RS14075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C4901_RS14080	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C4901_RS14085	COG0201	protein transport
C4901_RS14090	COG0200	Binds to the 23S rRNA
C4901_RS14095	COG1841	ribosomal large subunit assembly
C4901_RS14100	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C4901_RS14105	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C4901_RS14110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C4901_RS14115	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C4901_RS14125	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C4901_RS14130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C4901_RS14135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C4901_RS14140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C4901_RS14145	COG0255	Belongs to the universal ribosomal protein uL29 family
C4901_RS14150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C4901_RS14155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C4901_RS14160	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C4901_RS14165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C4901_RS14170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C4901_RS14175	COG0089	rRNA binding
C4901_RS14180	COG0088	Forms part of the polypeptide exit tunnel
C4901_RS14185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C4901_RS14190	COG0051	transcription antitermination factor activity, RNA binding
C4901_RS14195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4901_RS14200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C4901_RS14205	COG0049	tRNA binding
C4901_RS14210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C4901_RS14215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C4901_RS14220	COG0085	RNA polymerase activity
C4901_RS14225	COG0222	ribosome binding
C4901_RS14230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C4901_RS14235	COG0081	regulation of translation
C4901_RS14240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C4901_RS14245	COG0250	Participates in transcription elongation, termination and antitermination
C4901_RS14250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C4901_RS14265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4901_RS14270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C4901_RS14310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C4901_RS14315	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C4901_RS14315	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C4901_RS14355	COG0316	Belongs to the HesB IscA family
C4901_RS14370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C4901_RS14405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C4901_RS14415	COG3411	Ferredoxin
C4901_RS14420	COG0247	lactate metabolic process
C4901_RS14425	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C4901_RS14435	COG1765	OsmC-like protein
C4901_RS14440	COG0134	indole-3-glycerol-phosphate synthase activity
C4901_RS14445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C4901_RS14455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C4901_RS14460	COG0546	phosphoglycolate phosphatase activity
C4901_RS14470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C4901_RS14475	COG0363	glucosamine-6-phosphate deaminase activity
C4901_RS14485	COG0848	biopolymer transport protein
C4901_RS14490	COG0811	peptide transport
C4901_RS14500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C4901_RS14525	COG0469	pyruvate kinase activity
C4901_RS14530	COG0126	phosphoglycerate kinase activity
C4901_RS14535	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C4901_RS14540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C4901_RS14545	COG0572	uridine kinase
C4901_RS14550	COG0483	inositol monophosphate 1-phosphatase activity
C4901_RS14575	COG0643	Histidine kinase
C4901_RS14575	COG2198	Histidine kinase
C4901_RS14575	COG0784	Response regulator, receiver
C4901_RS14575	COG0784	Response regulator, receiver
C4901_RS14575	COG2198	Histidine kinase
C4901_RS14575	COG0643	Histidine kinase
C4901_RS14580	COG0840	transmembrane signaling receptor activity
C4901_RS14605	COG0189	ligase activity
C4901_RS14615	COG1678	Uncharacterized ACR, COG1678
C4901_RS14620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C4901_RS14625	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C4901_RS14630	COG0540	Belongs to the ATCase OTCase family
C4901_RS14650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C4901_RS14675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4901_RS14685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C4901_RS14690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4901_RS14695	COG2813	Specifically methylates the guanine in position
C4901_RS14695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C4901_RS14700	COG2807	transmembrane transport
C4901_RS14705	COG0708	Exodeoxyribonuclease III
C4901_RS14715	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C4901_RS14730	COG2046	Belongs to the sulfate adenylyltransferase family
C4901_RS14750	COG3300	MHYT domain
C4901_RS14750	COG5001	Diguanylate cyclase
C4901_RS14765	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
C4901_RS14785	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C4901_RS14790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C4901_RS14800	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C4901_RS14805	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
C4901_RS14810	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
C4901_RS14825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C4901_RS14835	COG5554	nitrogen fixation
C4901_RS14845	COG5554	nitrogen fixation
C4901_RS14855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C4901_RS14870	COG0316	Belongs to the HesB IscA family
C4901_RS14875	COG5001	Diguanylate cyclase
C4901_RS14875	COG3300	MHYT domain
C4901_RS14915	COG0822	iron-sulfur transferase activity
C4901_RS14995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C4901_RS15000	COG0009	L-threonylcarbamoyladenylate synthase
C4901_RS15005	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C4901_RS15010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C4901_RS15015	COG0129	dihydroxy-acid dehydratase activity
C4901_RS15020	COG0418	dihydroorotase activity
C4901_RS15030	COG3002	Belongs to the UPF0753 family
C4901_RS15035	COG0191	fructose-bisphosphate aldolase activity
C4901_RS15040	COG0583	DNA-binding transcription factor activity
C4901_RS15070	COG3300	MHYT domain
C4901_RS15070	COG5001	Diguanylate cyclase
C4901_RS15090	COG3002	Belongs to the UPF0753 family
C4901_RS15095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C4901_RS15125	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C4901_RS15135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C4901_RS15180	COG3311	Transcriptional regulator
C4901_RS15185	COG1569	PIN domain
C4901_RS15315	COG3609	addiction module antidote protein, CC2985 family
C4901_RS15345	COG4227	nucleotidyltransferase activity
C4901_RS15365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C4901_RS15550	COG5001	Diguanylate cyclase
C4901_RS15565	COG0450	alkyl hydroperoxide reductase
C4901_RS15570	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C4901_RS15575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C4901_RS15595	COG0175	sulfate reduction
C4901_RS15600	COG0583	DNA-binding transcription factor activity
C4901_RS15625	COG2857	Cytochrome c1
C4901_RS15635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C4901_RS15660	COG2863	cytochrome
C4901_RS15675	COG3300	MHYT domain
C4901_RS15675	COG5001	Diguanylate cyclase
C4901_RS15705	COG0601	transmembrane transport
C4901_RS15715	COG0444	Belongs to the ABC transporter superfamily
C4901_RS15720	COG4608	Belongs to the ABC transporter superfamily
C4901_RS15725	COG0210	DNA helicase
C4901_RS15735	COG0477	Major facilitator Superfamily
C4901_RS15740	COG0640	Transcriptional regulator
C4901_RS15820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C4901_RS15835	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C4901_RS15845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C4901_RS15850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C4901_RS15885	COG1028	Short-chain dehydrogenase reductase Sdr
C4901_RS15905	COG0617	tRNA 3'-terminal CCA addition
C4901_RS15930	COG1012	belongs to the aldehyde dehydrogenase family
C4901_RS15945	COG1331	Highly conserved protein containing a thioredoxin domain
C4901_RS15950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C4901_RS15965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C4901_RS15970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4901_RS15980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C4901_RS15990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C4901_RS16015	COG1215	transferase activity, transferring glycosyl groups
C4901_RS16030	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C4901_RS16055	COG0708	Exodeoxyribonuclease III
C4901_RS16065	COG0339	signal peptide processing
C4901_RS16070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C4901_RS16080	COG0625	glutathione transferase activity
C4901_RS16085	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C4901_RS16100	COG1196	nuclear chromosome segregation
C4901_RS16125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C4901_RS16135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C4901_RS16145	COG0194	GDP metabolic process
C4901_RS16150	COG2815	serine threonine protein kinase
C4901_RS16150	COG0515	serine threonine protein kinase
C4901_RS16155	COG0631	protein serine/threonine phosphatase activity
C4901_RS16160	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C4901_RS16170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C4901_RS16175	COG1981	membrane
C4901_RS16245	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C4901_RS16250	COG0830	nickel cation binding
C4901_RS16255	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C4901_RS16260	COG0804	urea catabolic process
C4901_RS16265	COG0832	Belongs to the urease beta subunit family
C4901_RS16270	COG0831	urea catabolic process
C4901_RS16275	COG0829	nickel cation binding
C4901_RS16285	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4901_RS16315	COG0003	Pfam Anion-transporting ATPase
C4901_RS16325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C4901_RS16330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C4901_RS16335	COG0493	'glutamate synthase
C4901_RS16340	COG0069	glutamate synthase activity
C4901_RS16340	COG0067	glutamate synthase
C4901_RS16340	COG0070	glutamate synthase
C4901_RS16345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C4901_RS16350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C4901_RS16410	COG0018	arginyl-trna synthetase
C4901_RS16420	COG2897	thiosulfate sulfurtransferase activity
C4901_RS16425	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C4901_RS16430	COG1116	anion transmembrane transporter activity
C4901_RS16435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C4901_RS16440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C4901_RS16440	COG1116	anion transmembrane transporter activity
C4901_RS16460	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C4901_RS16470	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C4901_RS16475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4901_RS16475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C4901_RS16490	COG1487	ribonuclease activity
C4901_RS16510	COG0330	HflC and HflK could
C4901_RS16535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C4901_RS16550	COG1846	Transcriptional regulator
C4901_RS16565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C4901_RS16570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C4901_RS16580	COG0625	glutathione transferase activity
C4901_RS16595	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C4901_RS16595	COG1618	nucleotide phosphatase activity, acting on free nucleotides
C4901_RS16600	COG0521	Mo-molybdopterin cofactor biosynthetic process
C4901_RS16605	COG0303	'Molybdopterin
C4901_RS16610	COG0746	molybdenum cofactor guanylyltransferase activity
C4901_RS16615	COG1432	Conserved Protein
C4901_RS16620	COG0243	molybdopterin cofactor binding
C4901_RS16630	COG2223	nitrite transmembrane transporter activity
C4901_RS16655	COG0004	ammonium transporteR
C4901_RS16660	COG0347	Belongs to the P(II) protein family
C4901_RS16665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C4901_RS16670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C4901_RS16700	COG3657	addiction module killer protein
C4901_RS16760	COG1074	ATP-dependent DNA helicase activity
C4901_RS16785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C4901_RS16820	COG3387	PFAM Glycoside hydrolase 15-related
C4901_RS16825	COG0254	rRNA binding
C4901_RS16830	COG0281	malic enzyme
C4901_RS16835	COG2890	protein-(glutamine-N5) methyltransferase activity
C4901_RS16855	COG1022	Amp-dependent synthetase and ligase
C4901_RS16865	COG0183	Belongs to the thiolase family
C4901_RS16870	COG1960	acyl-CoA dehydrogenase activity
C4901_RS16890	COG0135	phosphoribosylanthranilate isomerase activity
C4901_RS16935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C4901_RS16945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C4901_RS16950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C4901_RS16970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4901_RS16970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C4901_RS16975	COG1611	Belongs to the LOG family
C4901_RS16980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C4901_RS16995	COG0210	DNA helicase
C4901_RS17015	COG1842	Phage shock protein A
C4901_RS17035	COG1192	Involved in chromosome partitioning
C4901_RS17040	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C4901_RS17045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C4901_RS17050	COG1047	Peptidyl-prolyl cis-trans
C4901_RS17055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C4901_RS17060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C4901_RS17065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C4901_RS17070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C4901_RS17075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4901_RS17080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C4901_RS17085	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C4901_RS17090	COG0356	it plays a direct role in the translocation of protons across the membrane
C4901_RS17105	COG1475	DNA binding
C4901_RS17110	COG1192	Involved in chromosome partitioning
C4901_RS17120	COG0445	tRNA wobble uridine modification
C4901_RS17155	COG0714	Associated with various cellular activities
C4901_RS17170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C4901_RS17175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C4901_RS17180	COG0706	membrane insertase activity
C4901_RS17185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C4901_RS17190	COG0594	ribonuclease P activity