locus-tag	class	description
ASAC_RS00025	COG1518	maintenance of DNA repeat elements
ASAC_RS00025	COG1468	defense response to virus
ASAC_RS00090	COG1131	(ABC) transporter
ASAC_RS00100	COG1201	RNA secondary structure unwinding
ASAC_RS00120	COG0183	Belongs to the thiolase family
ASAC_RS00130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ASAC_RS00135	COG1830	Aldolase
ASAC_RS00140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASAC_RS00145	COG0163	prenyltransferase activity
ASAC_RS00175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ASAC_RS00195	COG0667	Aldo Keto reductase
ASAC_RS00210	COG1139	Iron-sulfur cluster binding protein
ASAC_RS00230	COG0494	nUDIX hydrolase
ASAC_RS00235	COG0823	Involved in the tonB-independent uptake of proteins
ASAC_RS00235	COG1506	peptidase
ASAC_RS00235	COG4946	Tricorn protease homolog
ASAC_RS00255	COG2046	Belongs to the sulfate adenylyltransferase family
ASAC_RS00265	COG0529	Catalyzes the synthesis of activated sulfate
ASAC_RS00285	COG0673	inositol 2-dehydrogenase activity
ASAC_RS00295	COG0601	transmembrane transport
ASAC_RS00310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ASAC_RS00330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASAC_RS00350	COG1489	DNA binding
ASAC_RS00380	COG0585	pseudouridine synthase activity
ASAC_RS00385	COG1216	Glycosyl transferase, family 2
ASAC_RS00395	COG0463	Glycosyl transferase, family 2
ASAC_RS00405	COG0714	Associated with various cellular activities
ASAC_RS00425	COG3842	ATPase activity
ASAC_RS00430	COG3833	ABC-type maltose transport systems, permease component
ASAC_RS00435	COG1175	transmembrane transport
ASAC_RS00450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASAC_RS00455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ASAC_RS00460	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASAC_RS00470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASAC_RS00475	COG1144	Oxidoreductase
ASAC_RS00480	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASAC_RS00485	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASAC_RS00490	COG0531	amino acid
ASAC_RS00500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASAC_RS00510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ASAC_RS00515	COG0113	porphobilinogen synthase activity
ASAC_RS00525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASAC_RS00530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASAC_RS00535	COG1881	PFAM PEBP family protein
ASAC_RS00550	COG0535	radical SAM domain protein
ASAC_RS00555	COG1522	sequence-specific DNA binding
ASAC_RS00560	COG0535	radical SAM domain protein
ASAC_RS00580	COG2235	arginine
ASAC_RS00595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASAC_RS00600	COG2181	nitrate reductase activity
ASAC_RS00600	COG0247	lactate metabolic process
ASAC_RS00645	COG0501	Belongs to the peptidase M48B family
ASAC_RS00650	COG0417	DNA replication proofreading
ASAC_RS00685	COG0423	glycine-tRNA ligase activity
ASAC_RS00690	COG0010	Belongs to the arginase family
ASAC_RS00700	COG0023	Translation Initiation Factor
ASAC_RS00705	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ASAC_RS00720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASAC_RS00730	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ASAC_RS00780	COG1960	acyl-CoA dehydrogenase activity
ASAC_RS00800	COG2095	MarC family integral membrane protein
ASAC_RS00815	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ASAC_RS00890	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ASAC_RS00895	COG1024	Enoyl-CoA hydratase
ASAC_RS00920	COG0314	molybdopterin synthase activity
ASAC_RS00930	COG1201	RNA secondary structure unwinding
ASAC_RS00950	COG1047	Peptidyl-prolyl cis-trans
ASAC_RS00960	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ASAC_RS00960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ASAC_RS00965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ASAC_RS00985	COG1234	tRNA 3'-trailer cleavage
ASAC_RS01005	COG0463	Glycosyl transferase, family 2
ASAC_RS01045	COG1185	polyribonucleotide nucleotidyltransferase activity
ASAC_RS01100	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
ASAC_RS01120	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ASAC_RS01130	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ASAC_RS01150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ASAC_RS01160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASAC_RS01175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASAC_RS01195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASAC_RS01200	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASAC_RS01205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASAC_RS01215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASAC_RS01240	COG0215	cysteine-tRNA ligase activity
ASAC_RS01255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ASAC_RS01325	COG0492	ferredoxin-NADP+ reductase activity
ASAC_RS01330	COG1802	Transcriptional regulator
ASAC_RS01355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ASAC_RS01360	COG2086	electron transfer activity
ASAC_RS01370	COG0644	oxidoreductase
ASAC_RS01385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ASAC_RS01390	COG1668	transmembrane transport
ASAC_RS01395	COG1131	(ABC) transporter
ASAC_RS01415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ASAC_RS01420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ASAC_RS01450	COG1994	Peptidase M50
ASAC_RS01470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASAC_RS01485	COG0039	L-malate dehydrogenase activity
ASAC_RS01500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ASAC_RS01520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASAC_RS01540	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
ASAC_RS01570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ASAC_RS01585	COG0343	queuine tRNA-ribosyltransferase activity
ASAC_RS01600	COG0549	Belongs to the carbamate kinase family
ASAC_RS01605	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ASAC_RS01620	COG0371	Dehydrogenase
ASAC_RS01625	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASAC_RS01630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ASAC_RS01650	COG0183	Belongs to the thiolase family
ASAC_RS01655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ASAC_RS01660	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ASAC_RS01680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASAC_RS01700	COG1304	FMN binding
ASAC_RS01715	COG3281	Trehalose synthase
ASAC_RS01730	COG0072	phenylalanine-tRNA ligase activity
ASAC_RS01745	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ASAC_RS01770	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ASAC_RS01780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASAC_RS01785	COG0037	tRNA processing
ASAC_RS01805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASAC_RS01810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASAC_RS01845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ASAC_RS01865	COG0297	glycogen (starch) synthase activity
ASAC_RS01875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASAC_RS01885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASAC_RS01890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASAC_RS01940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ASAC_RS01945	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASAC_RS01965	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ASAC_RS01970	COG0649	NAD binding
ASAC_RS01975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASAC_RS01980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASAC_RS02000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASAC_RS02005	COG0142	geranyltranstransferase activity
ASAC_RS02015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASAC_RS02025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASAC_RS02030	COG0442	prolyl-tRNA aminoacylation
ASAC_RS02040	COG0717	Belongs to the dCTP deaminase family
ASAC_RS02050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASAC_RS02055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASAC_RS02065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASAC_RS02075	COG0504	CTP synthase activity
ASAC_RS02095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASAC_RS02110	COG0017	Asparaginyl-tRNA synthetase
ASAC_RS02145	COG1269	ATP hydrolysis coupled proton transport
ASAC_RS02160	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
ASAC_RS02165	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
ASAC_RS02200	COG0551	DNA topoisomerase type I activity
ASAC_RS02200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASAC_RS02210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASAC_RS02230	COG0247	lactate metabolic process
ASAC_RS02250	COG1201	RNA secondary structure unwinding
ASAC_RS02255	COG0459	protein refolding
ASAC_RS02275	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ASAC_RS02280	COG1129	ABC transporter
ASAC_RS02285	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ASAC_RS02290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASAC_RS02310	COG2890	protein-(glutamine-N5) methyltransferase activity
ASAC_RS02315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ASAC_RS02350	COG0017	Asparaginyl-tRNA synthetase
ASAC_RS02365	COG2017	converts alpha-aldose to the beta-anomer
ASAC_RS02375	COG2860	membrane
ASAC_RS02390	COG0154	amidase activity
ASAC_RS02395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASAC_RS02440	COG3842	ATPase activity
ASAC_RS02455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASAC_RS02460	COG2151	metal-sulfur cluster biosynthetic enzyme
ASAC_RS02470	COG1058	Belongs to the CinA family
ASAC_RS02470	COG1546	Belongs to the CinA family
ASAC_RS02480	COG1394	ATPase activity, coupled to movement of substances
ASAC_RS02490	COG0483	inositol monophosphate 1-phosphatase activity
ASAC_RS02505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ASAC_RS02530	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ASAC_RS02560	COG1120	ATPase activity
ASAC_RS02565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASAC_RS02570	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ASAC_RS02575	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ASAC_RS02620	COG0318	PFAM AMP-dependent synthetase and ligase
ASAC_RS02645	COG0864	Transcriptional regulator
ASAC_RS02670	COG0537	adenosine 5'-monophosphoramidase activity
ASAC_RS02675	COG0587	DNA-directed DNA polymerase activity
ASAC_RS02685	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ASAC_RS02720	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ASAC_RS02725	COG0426	domain, Protein
ASAC_RS02735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASAC_RS02750	COG0114	fumarate hydratase activity
ASAC_RS02760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASAC_RS02770	COG0730	response to heat
ASAC_RS02785	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ASAC_RS02795	COG4670	ketone body catabolic process
ASAC_RS02805	COG0095	Lipoate-protein ligase
ASAC_RS02810	COG0517	IMP dehydrogenase activity
ASAC_RS02810	COG0516	GMP reductase activity
ASAC_RS02820	COG0514	ATP-dependent DNA helicase (RecQ)
ASAC_RS02835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASAC_RS02850	COG2814	Major facilitator Superfamily
ASAC_RS02865	COG0726	polysaccharide deacetylase
ASAC_RS02880	COG1028	Short-chain dehydrogenase reductase Sdr
ASAC_RS02900	COG0179	Fumarylacetoacetate (FAA) hydrolase
ASAC_RS02905	COG0667	Aldo Keto reductase
ASAC_RS02910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ASAC_RS02925	COG2986	histidine ammonia-lyase
ASAC_RS02930	COG0010	Belongs to the arginase family
ASAC_RS02945	COG2409	Drug exporters of the RND superfamily
ASAC_RS02960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASAC_RS02970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ASAC_RS02975	COG1960	acyl-CoA dehydrogenase activity
ASAC_RS02985	COG0450	alkyl hydroperoxide reductase
ASAC_RS03005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASAC_RS03015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASAC_RS03050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASAC_RS03055	COG1584	GPR1 FUN34 yaaH family protein
ASAC_RS03075	COG0477	Major facilitator Superfamily
ASAC_RS03095	COG0395	ABC-type sugar transport system, permease component
ASAC_RS03140	COG0436	Aminotransferase
ASAC_RS03150	COG0301	tRNA thio-modification
ASAC_RS03175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASAC_RS03210	COG0604	alcohol dehydrogenase
ASAC_RS03220	COG1575	Belongs to the MenA family. Type 1 subfamily
ASAC_RS03230	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
ASAC_RS03245	COG1215	transferase activity, transferring glycosyl groups
ASAC_RS03320	COG2264	protein methyltransferase activity
ASAC_RS03350	COG1215	transferase activity, transferring glycosyl groups
ASAC_RS03375	COG1215	transferase activity, transferring glycosyl groups
ASAC_RS03430	COG0438	transferase activity, transferring glycosyl groups
ASAC_RS03435	COG1215	transferase activity, transferring glycosyl groups
ASAC_RS03440	COG0297	glycogen (starch) synthase activity
ASAC_RS03450	COG1215	transferase activity, transferring glycosyl groups
ASAC_RS03515	COG2414	aldehyde ferredoxin oxidoreductase
ASAC_RS03525	COG1454	alcohol dehydrogenase
ASAC_RS03530	COG0393	Putative heavy-metal-binding
ASAC_RS03545	COG1228	amidohydrolase
ASAC_RS03550	COG1132	(ABC) transporter
ASAC_RS03565	COG2210	Belongs to the sulfur carrier protein TusA family
ASAC_RS03590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASAC_RS03655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ASAC_RS03710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASAC_RS03710	COG0574	Belongs to the PEP-utilizing enzyme family
ASAC_RS03725	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ASAC_RS03730	COG1012	belongs to the aldehyde dehydrogenase family
ASAC_RS03750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASAC_RS03780	COG0009	L-threonylcarbamoyladenylate synthase
ASAC_RS03815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASAC_RS03835	COG2414	aldehyde ferredoxin oxidoreductase
ASAC_RS03840	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASAC_RS03845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ASAC_RS03880	COG1501	Belongs to the glycosyl hydrolase 31 family
ASAC_RS03885	COG0531	amino acid
ASAC_RS03890	COG1215	transferase activity, transferring glycosyl groups
ASAC_RS03910	COG2096	Adenosyltransferase
ASAC_RS03915	COG1012	belongs to the aldehyde dehydrogenase family
ASAC_RS03925	COG0109	protoheme IX farnesyltransferase activity
ASAC_RS03925	COG1612	heme a metabolic process
ASAC_RS03930	COG0730	response to heat
ASAC_RS03945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASAC_RS03955	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASAC_RS03960	COG1085	galactose-1-phosphate uridylyltransferase
ASAC_RS03965	COG1254	Belongs to the acylphosphatase family
ASAC_RS03970	COG0709	Synthesizes selenophosphate from selenide and ATP
ASAC_RS03980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ASAC_RS03985	COG0463	Glycosyl transferase, family 2
ASAC_RS03995	COG0154	amidase activity
ASAC_RS04025	COG1446	asparaginase
ASAC_RS04035	COG0601	transmembrane transport
ASAC_RS04040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASAC_RS04045	COG0444	Belongs to the ABC transporter superfamily
ASAC_RS04050	COG4608	Belongs to the ABC transporter superfamily
ASAC_RS04070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ASAC_RS04090	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ASAC_RS04095	COG0538	isocitrate dehydrogenase activity
ASAC_RS04125	COG0430	RNA-3'-phosphate cyclase activity
ASAC_RS04140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASAC_RS04145	COG0436	Aminotransferase
ASAC_RS04155	COG1324	tolerance protein
ASAC_RS04165	COG0148	phosphopyruvate hydratase activity
ASAC_RS04170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ASAC_RS04205	COG1028	Short-chain dehydrogenase reductase Sdr
ASAC_RS04220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ASAC_RS04220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ASAC_RS04240	COG1335	isochorismatase
ASAC_RS04255	COG1575	Belongs to the MenA family. Type 1 subfamily
ASAC_RS04295	COG0517	IMP dehydrogenase activity
ASAC_RS04295	COG0516	GMP reductase activity
ASAC_RS04300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASAC_RS04300	COG0519	Catalyzes the synthesis of GMP from XMP
ASAC_RS04305	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ASAC_RS04365	COG0372	Belongs to the citrate synthase family
ASAC_RS04380	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASAC_RS04385	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASAC_RS04385	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASAC_RS04405	COG1940	carbohydrate kinase activity
ASAC_RS04450	COG1573	uracil-dna glycosylase
ASAC_RS04480	COG0126	phosphoglycerate kinase activity
ASAC_RS04505	COG1573	uracil-dna glycosylase
ASAC_RS04535	COG2814	Major facilitator Superfamily
ASAC_RS04540	COG1355	regulation of microtubule-based process
ASAC_RS04550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASAC_RS04560	COG1061	Type III restriction enzyme res subunit
ASAC_RS04580	COG0330	HflC and HflK could
ASAC_RS04615	COG0037	tRNA processing
ASAC_RS04640	COG4581	dead DEAH box helicase
ASAC_RS04665	COG0318	PFAM AMP-dependent synthetase and ligase
ASAC_RS04670	COG4948	Mandelate Racemase Muconate Lactonizing
ASAC_RS04695	COG0450	alkyl hydroperoxide reductase
ASAC_RS04700	COG0489	protein tyrosine kinase activity
ASAC_RS04705	COG0089	rRNA binding
ASAC_RS04715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASAC_RS04720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASAC_RS04730	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ASAC_RS04735	COG1116	anion transmembrane transporter activity
ASAC_RS04745	COG0604	alcohol dehydrogenase
ASAC_RS04765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ASAC_RS04765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ASAC_RS04780	COG2078	PFAM AMMECR1 domain protein
ASAC_RS04805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASAC_RS04810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASAC_RS04825	COG0419	ATPase involved in DNA repair
ASAC_RS04825	COG0419	ATPase involved in DNA repair
ASAC_RS04835	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ASAC_RS04860	COG0517	IMP dehydrogenase activity
ASAC_RS04860	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ASAC_RS04875	COG0167	dihydroorotate dehydrogenase activity
ASAC_RS04880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASAC_RS04885	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ASAC_RS04890	COG0540	Belongs to the ATCase OTCase family
ASAC_RS04895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASAC_RS04900	COG0284	orotidine-5'-phosphate decarboxylase activity
ASAC_RS04910	COG4948	Mandelate Racemase Muconate Lactonizing
ASAC_RS04950	COG1175	transmembrane transport
ASAC_RS04955	COG0395	ABC-type sugar transport system, permease component
ASAC_RS04960	COG3842	ATPase activity
ASAC_RS04965	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ASAC_RS04985	COG3118	belongs to the thioredoxin family
ASAC_RS04990	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ASAC_RS05010	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ASAC_RS05015	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASAC_RS05025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASAC_RS05045	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ASAC_RS05055	COG0052	Belongs to the universal ribosomal protein uS2 family
ASAC_RS05065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ASAC_RS05070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ASAC_RS05075	COG0200	Binds to the 23S rRNA
ASAC_RS05085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASAC_RS05090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ASAC_RS05095	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASAC_RS05105	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ASAC_RS05115	COG0667	Aldo Keto reductase
ASAC_RS05140	COG0109	protoheme IX farnesyltransferase activity
ASAC_RS05145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASAC_RS05155	COG2379	hydroxypyruvate reductase
ASAC_RS05160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ASAC_RS05160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASAC_RS05190	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASAC_RS05210	COG1250	3-hydroxyacyl-CoA dehydrogenase
ASAC_RS05235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASAC_RS05270	COG1960	acyl-CoA dehydrogenase activity
ASAC_RS05290	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ASAC_RS05310	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ASAC_RS05325	COG0714	Associated with various cellular activities
ASAC_RS05330	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASAC_RS05335	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASAC_RS05340	COG1144	Oxidoreductase
ASAC_RS05365	COG1201	RNA secondary structure unwinding
ASAC_RS05370	COG2814	Major facilitator Superfamily
ASAC_RS05375	COG0295	cytidine deaminase activity
ASAC_RS05380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASAC_RS05400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ASAC_RS05405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ASAC_RS05415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASAC_RS05415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASAC_RS05425	COG1061	Type III restriction enzyme res subunit
ASAC_RS05430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ASAC_RS05435	COG0045	succinate-CoA ligase (ADP-forming) activity
ASAC_RS05440	COG0366	Alpha amylase catalytic
ASAC_RS05455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASAC_RS05455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASAC_RS05460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASAC_RS05460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ASAC_RS05485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASAC_RS05520	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASAC_RS05530	COG0105	UTP biosynthetic process
ASAC_RS05535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASAC_RS05565	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
ASAC_RS05580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ASAC_RS05640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ASAC_RS05645	COG0517	IMP dehydrogenase activity
ASAC_RS05645	COG0516	GMP reductase activity
ASAC_RS05655	COG0517	IMP dehydrogenase activity
ASAC_RS05655	COG0516	GMP reductase activity
ASAC_RS05765	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ASAC_RS05770	COG1185	polyribonucleotide nucleotidyltransferase activity
ASAC_RS05785	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASAC_RS05815	COG0495	leucyl-tRNA aminoacylation
ASAC_RS05840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ASAC_RS05855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASAC_RS05875	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ASAC_RS05880	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
ASAC_RS05905	COG2814	Major facilitator Superfamily
ASAC_RS05920	COG1252	NADH dehydrogenase
ASAC_RS05955	COG0085	RNA polymerase activity
ASAC_RS05965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASAC_RS05990	COG0049	tRNA binding
ASAC_RS05995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASAC_RS06000	COG0051	transcription antitermination factor activity, RNA binding
ASAC_RS06010	COG1793	dna ligase
ASAC_RS06020	COG1028	Short-chain dehydrogenase reductase Sdr
ASAC_RS06030	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ASAC_RS06100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASAC_RS06105	COG0181	hydroxymethylbilane synthase activity
ASAC_RS06110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASAC_RS06120	COG1078	dGTPase activity
ASAC_RS06125	COG2222	sugar isomerase
ASAC_RS06140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ASAC_RS06230	COG1980	fructose-bisphosphate aldolase activity
ASAC_RS06235	COG2022	thiamine diphosphate biosynthetic process
ASAC_RS06245	COG1960	acyl-CoA dehydrogenase activity
ASAC_RS06250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ASAC_RS06260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASAC_RS06265	COG0444	Belongs to the ABC transporter superfamily
ASAC_RS06270	COG4608	Belongs to the ABC transporter superfamily
ASAC_RS06300	COG1110	DNA topoisomerase II activity
ASAC_RS06305	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ASAC_RS06310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASAC_RS06320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASAC_RS06330	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ASAC_RS06355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ASAC_RS06365	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ASAC_RS06390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASAC_RS06415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASAC_RS06420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ASAC_RS06435	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ASAC_RS06460	COG0351	phosphomethylpyrimidine kinase
ASAC_RS06465	COG0309	Hydrogenase expression formation protein (HypE)
ASAC_RS06480	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ASAC_RS06485	COG0719	Fe-S assembly protein
ASAC_RS06490	COG0719	Fe-S assembly protein
ASAC_RS06495	COG0396	ATPase activity
ASAC_RS06505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASAC_RS06535	COG2086	electron transfer activity
ASAC_RS06540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ASAC_RS06545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASAC_RS06545	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASAC_RS06550	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASAC_RS06565	COG2414	aldehyde ferredoxin oxidoreductase
ASAC_RS06570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ASAC_RS06585	COG0535	radical SAM domain protein
ASAC_RS06595	COG1051	belongs to the nudix hydrolase family
ASAC_RS06610	COG2391	methyltransferase activity
ASAC_RS06615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ASAC_RS06620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASAC_RS06630	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ASAC_RS06645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASAC_RS06650	COG0252	asparaginase activity
ASAC_RS06675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ASAC_RS06685	COG1522	sequence-specific DNA binding
ASAC_RS06745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ASAC_RS06755	COG2267	carboxylic ester hydrolase activity
ASAC_RS06780	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ASAC_RS06785	COG0277	FAD linked oxidase domain protein
ASAC_RS06790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASAC_RS06795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ASAC_RS06860	COG0417	DNA replication proofreading
ASAC_RS06870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASAC_RS06890	COG2084	Dehydrogenase
ASAC_RS06915	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASAC_RS06945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASAC_RS06950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASAC_RS06955	COG0792	nuclease activity
ASAC_RS06960	COG4555	ABC transporter
ASAC_RS06985	COG1472	Belongs to the glycosyl hydrolase 3 family
ASAC_RS06995	COG4608	Belongs to the ABC transporter superfamily
ASAC_RS07000	COG4608	Belongs to the ABC transporter superfamily
ASAC_RS07010	COG0601	transmembrane transport
ASAC_RS07025	COG0126	phosphoglycerate kinase activity
ASAC_RS07030	COG0589	response to stress
ASAC_RS07035	COG2814	Major facilitator Superfamily
ASAC_RS07040	COG2723	6-phospho-beta-galactosidase activity
ASAC_RS07045	COG1575	Belongs to the MenA family. Type 1 subfamily
ASAC_RS07050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ASAC_RS07075	COG3383	formate dehydrogenase (NAD+) activity
ASAC_RS07080	COG0746	molybdenum cofactor guanylyltransferase activity
ASAC_RS07105	COG0006	proline dipeptidase activity
ASAC_RS07150	COG1131	(ABC) transporter
ASAC_RS07230	COG0493	'glutamate synthase
ASAC_RS07240	COG2226	methyltransferase
ASAC_RS07255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ASAC_RS07260	COG1024	Enoyl-CoA hydratase
ASAC_RS07270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ASAC_RS07280	COG0477	Major facilitator Superfamily
ASAC_RS07295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASAC_RS07305	COG2009	succinate dehydrogenase
ASAC_RS07315	COG0509	glycine decarboxylation via glycine cleavage system
ASAC_RS07320	COG0312	modulator of DNA gyrase
ASAC_RS07335	COG3273	potassium ion transport
ASAC_RS07335	COG0471	metal ion transport
ASAC_RS07345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ASAC_RS07350	COG4935	Belongs to the peptidase S8 family
ASAC_RS07350	COG2234	aminopeptidase activity
ASAC_RS07380	COG1444	tRNA N-acetyltransferase activity
ASAC_RS07430	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ASAC_RS07475	COG1131	(ABC) transporter
ASAC_RS07480	COG1028	Short-chain dehydrogenase reductase Sdr
ASAC_RS07510	COG0124	histidyl-tRNA synthetase
ASAC_RS07540	COG0442	prolyl-tRNA aminoacylation
ASAC_RS07560	COG0588	phosphoglycerate mutase activity
ASAC_RS07575	COG0531	amino acid
ASAC_RS07615	COG3842	ATPase activity
ASAC_RS07635	COG0444	Belongs to the ABC transporter superfamily
ASAC_RS07685	COG2255	four-way junction helicase activity