locus-tag	class	description
SE86_RS00015	COG0315	cyclic pyranopterin monophosphate synthase activity
SE86_RS00035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SE86_RS00065	COG0277	FAD linked oxidase domain protein
SE86_RS00080	COG2267	carboxylic ester hydrolase activity
SE86_RS00105	COG0640	Transcriptional regulator
SE86_RS00125	COG0417	DNA replication proofreading
SE86_RS00135	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SE86_RS00155	COG2084	Dehydrogenase
SE86_RS00185	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SE86_RS00190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SE86_RS00220	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SE86_RS00250	COG1584	GPR1 FUN34 yaaH family protein
SE86_RS00255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SE86_RS00265	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SE86_RS00270	COG1193	negative regulation of DNA recombination
SE86_RS00300	COG0477	Major facilitator Superfamily
SE86_RS00310	COG1592	Rubrerythrin
SE86_RS00340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SE86_RS00350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SE86_RS00380	COG0393	Putative heavy-metal-binding
SE86_RS00445	COG1960	acyl-CoA dehydrogenase activity
SE86_RS00450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SE86_RS00470	COG0438	transferase activity, transferring glycosyl groups
SE86_RS00535	COG1215	transferase activity, transferring glycosyl groups
SE86_RS00540	COG1215	transferase activity, transferring glycosyl groups
SE86_RS00570	COG0604	alcohol dehydrogenase
SE86_RS00615	COG1454	alcohol dehydrogenase
SE86_RS00625	COG2414	aldehyde ferredoxin oxidoreductase
SE86_RS00635	COG0301	tRNA thio-modification
SE86_RS00635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SE86_RS00655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SE86_RS00690	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SE86_RS00695	COG0010	Belongs to the arginase family
SE86_RS00700	COG2986	histidine ammonia-lyase
SE86_RS00705	COG1228	amidohydrolase
SE86_RS00715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SE86_RS00720	COG0667	Aldo Keto reductase
SE86_RS00725	COG0179	Fumarylacetoacetate (FAA) hydrolase
SE86_RS00740	COG0730	response to heat
SE86_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
SE86_RS00755	COG0438	transferase activity, transferring glycosyl groups
SE86_RS00775	COG2814	Major facilitator Superfamily
SE86_RS00790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SE86_RS00805	COG0514	ATP-dependent DNA helicase (RecQ)
SE86_RS00830	COG4670	ketone body catabolic process
SE86_RS00870	COG1131	(ABC) transporter
SE86_RS00880	COG1201	RNA secondary structure unwinding
SE86_RS00900	COG0183	Belongs to the thiolase family
SE86_RS00910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SE86_RS00930	COG1830	Aldolase
SE86_RS00935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SE86_RS00940	COG0163	prenyltransferase activity
SE86_RS00970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SE86_RS00985	COG0667	Aldo Keto reductase
SE86_RS01010	COG1139	Iron-sulfur cluster binding protein
SE86_RS01030	COG0494	nUDIX hydrolase
SE86_RS01035	COG1506	peptidase
SE86_RS01035	COG0823	Involved in the tonB-independent uptake of proteins
SE86_RS01035	COG4946	Tricorn protease homolog
SE86_RS01065	COG0529	Catalyzes the synthesis of activated sulfate
SE86_RS01110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SE86_RS01130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SE86_RS01145	COG1489	DNA binding
SE86_RS01175	COG0585	pseudouridine synthase activity
SE86_RS01195	COG3842	ATPase activity
SE86_RS01205	COG1175	transmembrane transport
SE86_RS01220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SE86_RS01225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SE86_RS01230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SE86_RS01240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SE86_RS01245	COG1144	Oxidoreductase
SE86_RS01250	COG0674	pyruvate-flavodoxin oxidoreductase activity
SE86_RS01255	COG1013	pyruvate-flavodoxin oxidoreductase activity
SE86_RS01260	COG0531	amino acid
SE86_RS01270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SE86_RS01285	COG0113	porphobilinogen synthase activity
SE86_RS01290	COG1213	nucleotidyl transferase
SE86_RS01295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SE86_RS01300	COG1881	PFAM PEBP family protein
SE86_RS01315	COG0535	radical SAM domain protein
SE86_RS01325	COG0535	radical SAM domain protein
SE86_RS01330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SE86_RS01330	COG1648	precorrin-2 dehydrogenase activity
SE86_RS01365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SE86_RS01370	COG2181	nitrate reductase activity
SE86_RS01370	COG0247	lactate metabolic process
SE86_RS01390	COG0174	glutamine synthetase
SE86_RS01405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SE86_RS01415	COG0501	Belongs to the peptidase M48B family
SE86_RS01425	COG0417	DNA replication proofreading
SE86_RS01460	COG0423	glycine-tRNA ligase activity
SE86_RS01475	COG0023	Translation Initiation Factor
SE86_RS01480	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SE86_RS01495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SE86_RS01505	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SE86_RS01530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SE86_RS01550	COG1960	acyl-CoA dehydrogenase activity
SE86_RS01565	COG2095	MarC family integral membrane protein
SE86_RS01580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SE86_RS01660	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SE86_RS01665	COG1024	Enoyl-CoA hydratase
SE86_RS01685	COG0314	molybdopterin synthase activity
SE86_RS01695	COG1201	RNA secondary structure unwinding
SE86_RS01715	COG1047	Peptidyl-prolyl cis-trans
SE86_RS01725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SE86_RS01725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SE86_RS01730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SE86_RS01750	COG1234	tRNA 3'-trailer cleavage
SE86_RS01755	COG0116	Belongs to the methyltransferase superfamily
SE86_RS01765	COG0463	Glycosyl transferase, family 2
SE86_RS01815	COG0539	negative regulation of cytoplasmic translation
SE86_RS01860	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
SE86_RS01880	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
SE86_RS01885	COG1618	nucleotide phosphatase activity, acting on free nucleotides
SE86_RS01900	COG1899	peptidyl-lysine modification to peptidyl-hypusine
SE86_RS01920	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SE86_RS01945	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SE86_RS01955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SE86_RS02005	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SE86_RS02015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SE86_RS02025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SE86_RS02040	COG0215	cysteine-tRNA ligase activity
SE86_RS02065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SE86_RS02075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SE86_RS02085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SE86_RS02090	COG0255	Belongs to the universal ribosomal protein uL29 family
SE86_RS02110	COG0644	oxidoreductase
SE86_RS02120	COG2086	electron transfer activity
SE86_RS02125	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SE86_RS02155	COG1802	Transcriptional regulator
SE86_RS02160	COG0492	ferredoxin-NADP+ reductase activity
SE86_RS02200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SE86_RS02225	COG1994	Peptidase M50
SE86_RS02245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SE86_RS02255	COG0525	valine-tRNA ligase activity
SE86_RS02260	COG0039	L-malate dehydrogenase activity
SE86_RS02275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SE86_RS02295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SE86_RS02315	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
SE86_RS02345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SE86_RS02390	COG0459	protein refolding
SE86_RS02395	COG0371	Dehydrogenase
SE86_RS02400	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SE86_RS02405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SE86_RS02425	COG0183	Belongs to the thiolase family
SE86_RS02430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SE86_RS02435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SE86_RS02440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SE86_RS02460	COG2226	methyltransferase
SE86_RS02480	COG1304	FMN binding
SE86_RS02505	COG1469	GTP cyclohydrolase I activity
SE86_RS02510	COG0072	phenylalanine-tRNA ligase activity
SE86_RS02525	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SE86_RS02550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SE86_RS02560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SE86_RS02565	COG0037	tRNA processing
SE86_RS02595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SE86_RS02600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SE86_RS02640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SE86_RS02660	COG0297	glycogen (starch) synthase activity
SE86_RS02680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SE86_RS02690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SE86_RS02715	COG3842	ATPase activity
SE86_RS02745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SE86_RS02750	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SE86_RS02770	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SE86_RS02775	COG0649	NAD binding
SE86_RS02780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SE86_RS02785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SE86_RS02805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SE86_RS02820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SE86_RS02830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SE86_RS02835	COG0442	prolyl-tRNA aminoacylation
SE86_RS02890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SE86_RS02900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SE86_RS02910	COG0504	CTP synthase activity
SE86_RS02930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SE86_RS02950	COG0017	Asparaginyl-tRNA synthetase
SE86_RS02985	COG1269	ATP hydrolysis coupled proton transport
SE86_RS03000	COG0247	lactate metabolic process
SE86_RS03025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SE86_RS03035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SE86_RS03035	COG0551	DNA topoisomerase type I activity
SE86_RS03070	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SE86_RS03075	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SE86_RS03095	COG1201	RNA secondary structure unwinding
SE86_RS03100	COG0459	protein refolding
SE86_RS03120	COG0024	Methionine aminopeptidase
SE86_RS03125	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SE86_RS03130	COG0488	(ABC) transporter
SE86_RS03135	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
SE86_RS03140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SE86_RS03160	COG2890	protein-(glutamine-N5) methyltransferase activity
SE86_RS03165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SE86_RS03200	COG0017	Asparaginyl-tRNA synthetase
SE86_RS03245	COG0154	amidase activity
SE86_RS03250	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SE86_RS03290	COG3842	ATPase activity
SE86_RS03305	COG2151	metal-sulfur cluster biosynthetic enzyme
SE86_RS03310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SE86_RS03315	COG1058	Belongs to the CinA family
SE86_RS03315	COG1546	Belongs to the CinA family
SE86_RS03325	COG1394	ATPase activity, coupled to movement of substances
SE86_RS03335	COG0483	inositol monophosphate 1-phosphatase activity
SE86_RS03370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SE86_RS03400	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SE86_RS03405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SE86_RS03415	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SE86_RS03470	COG0318	PFAM AMP-dependent synthetase and ligase
SE86_RS03475	COG0281	malic enzyme
SE86_RS03495	COG0864	Transcriptional regulator
SE86_RS03505	COG1522	sequence-specific DNA binding
SE86_RS03520	COG0537	adenosine 5'-monophosphoramidase activity
SE86_RS03525	COG0587	DNA-directed DNA polymerase activity
SE86_RS03555	COG1113	amino acid transport
SE86_RS03560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SE86_RS03585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SE86_RS03650	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SE86_RS03660	COG2723	6-phospho-beta-galactosidase activity
SE86_RS03675	COG1472	Belongs to the glycosyl hydrolase 3 family
SE86_RS03705	COG0444	Belongs to the ABC transporter superfamily
SE86_RS03710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SE86_RS03715	COG0601	transmembrane transport
SE86_RS03720	COG0746	molybdenum cofactor guanylyltransferase activity
SE86_RS03740	COG0436	Aminotransferase
SE86_RS03815	COG0124	histidyl-tRNA synthetase
SE86_RS03855	COG1131	(ABC) transporter
SE86_RS03875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SE86_RS03880	COG2848	UPF0210 protein
SE86_RS03925	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SE86_RS03935	COG1444	tRNA N-acetyltransferase activity
SE86_RS03955	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
SE86_RS03970	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SE86_RS03975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SE86_RS03995	COG2009	succinate dehydrogenase
SE86_RS04005	COG0509	glycine decarboxylation via glycine cleavage system
SE86_RS04010	COG0312	modulator of DNA gyrase
SE86_RS04025	COG3273	potassium ion transport
SE86_RS04025	COG0471	metal ion transport
SE86_RS04035	COG0531	amino acid
SE86_RS04040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SE86_RS04055	COG1024	Enoyl-CoA hydratase
SE86_RS04060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SE86_RS04090	COG0493	'glutamate synthase
SE86_RS04145	COG0531	amino acid
SE86_RS04150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SE86_RS04190	COG3383	formate dehydrogenase (NAD+) activity
SE86_RS04195	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SE86_RS04245	COG0006	proline dipeptidase activity
SE86_RS04250	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SE86_RS04270	COG0126	phosphoglycerate kinase activity
SE86_RS04300	COG4555	ABC transporter
SE86_RS04325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SE86_RS04335	COG0426	domain, Protein
SE86_RS04350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SE86_RS04360	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SE86_RS04410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SE86_RS04410	COG0574	Belongs to the PEP-utilizing enzyme family
SE86_RS04420	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SE86_RS04430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SE86_RS04465	COG0009	L-threonylcarbamoyladenylate synthase
SE86_RS04490	COG0667	Aldo Keto reductase
SE86_RS04500	COG4948	Mandelate Racemase Muconate Lactonizing
SE86_RS04520	COG0284	orotidine-5'-phosphate decarboxylase activity
SE86_RS04525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SE86_RS04530	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SE86_RS04535	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
SE86_RS04545	COG0517	IMP dehydrogenase activity
SE86_RS04545	COG1125	glycine betaine transport
SE86_RS04565	COG0167	dihydroorotate dehydrogenase activity
SE86_RS04570	COG0114	fumarate hydratase activity
SE86_RS04620	COG0393	Putative heavy-metal-binding
SE86_RS04640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SE86_RS04680	COG2409	Drug exporters of the RND superfamily
SE86_RS04700	COG0535	radical SAM domain protein
SE86_RS04715	COG1309	transcriptional regulator
SE86_RS04730	COG0531	amino acid
SE86_RS04740	COG0535	radical SAM domain protein
SE86_RS04805	COG1401	restriction endodeoxyribonuclease activity
SE86_RS04845	COG0559	Belongs to the binding-protein-dependent transport system permease family
SE86_RS04855	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SE86_RS04860	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SE86_RS04880	COG0588	phosphoglycerate mutase activity
SE86_RS04905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SE86_RS04930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SE86_RS04955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SE86_RS04965	COG1454	alcohol dehydrogenase
SE86_RS04990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SE86_RS05005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SE86_RS05020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SE86_RS05030	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SE86_RS05035	COG0420	3'-5' exonuclease activity
SE86_RS05040	COG0419	ATPase involved in DNA repair
SE86_RS05040	COG0419	ATPase involved in DNA repair
SE86_RS05060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SE86_RS05085	COG2078	PFAM AMMECR1 domain protein
SE86_RS05100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SE86_RS05100	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SE86_RS05105	COG0251	oxidation-reduction process
SE86_RS05130	COG1116	anion transmembrane transporter activity
SE86_RS05135	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SE86_RS05165	COG1573	uracil-dna glycosylase
SE86_RS05195	COG0126	phosphoglycerate kinase activity
SE86_RS05220	COG1573	uracil-dna glycosylase
SE86_RS05255	COG2814	Major facilitator Superfamily
SE86_RS05260	COG1355	regulation of microtubule-based process
SE86_RS05280	COG1061	Type III restriction enzyme res subunit
SE86_RS05300	COG0330	HflC and HflK could
SE86_RS05315	COG4581	dead DEAH box helicase
SE86_RS05340	COG0037	tRNA processing
SE86_RS05365	COG0740	serine-type endopeptidase activity
SE86_RS05380	COG0318	PFAM AMP-dependent synthetase and ligase
SE86_RS05385	COG4948	Mandelate Racemase Muconate Lactonizing
SE86_RS05410	COG0489	protein tyrosine kinase activity
SE86_RS05420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SE86_RS05425	COG0089	rRNA binding
SE86_RS05455	COG1940	carbohydrate kinase activity
SE86_RS05480	COG1013	pyruvate-flavodoxin oxidoreductase activity
SE86_RS05490	COG0372	Belongs to the citrate synthase family
SE86_RS05505	COG2814	Major facilitator Superfamily
SE86_RS05550	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SE86_RS05555	COG0519	Catalyzes the synthesis of GMP from XMP
SE86_RS05555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SE86_RS05560	COG0517	IMP dehydrogenase activity
SE86_RS05560	COG0516	GMP reductase activity
SE86_RS05575	COG1175	transmembrane transport
SE86_RS05625	COG1575	Belongs to the MenA family. Type 1 subfamily
SE86_RS05640	COG1335	isochorismatase
SE86_RS05660	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SE86_RS05660	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SE86_RS05705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SE86_RS05710	COG0148	phosphopyruvate hydratase activity
SE86_RS05720	COG1324	tolerance protein
SE86_RS05725	COG0072	phenylalanine-tRNA ligase activity
SE86_RS05725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SE86_RS05730	COG0436	Aminotransferase
SE86_RS05735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SE86_RS05750	COG0430	RNA-3'-phosphate cyclase activity
SE86_RS05780	COG0538	isocitrate dehydrogenase activity
SE86_RS05785	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SE86_RS05805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SE86_RS05830	COG0444	Belongs to the ABC transporter superfamily
SE86_RS05835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SE86_RS05850	COG1446	asparaginase
SE86_RS05855	COG0154	amidase activity
SE86_RS05860	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SE86_RS05865	COG0463	Glycosyl transferase, family 2
SE86_RS05870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SE86_RS05885	COG1254	Belongs to the acylphosphatase family
SE86_RS05895	COG1085	galactose-1-phosphate uridylyltransferase
SE86_RS05900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SE86_RS05910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SE86_RS05925	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SE86_RS05955	COG0463	Glycosyl transferase, family 2
SE86_RS05960	COG0531	amino acid
SE86_RS05965	COG1501	Belongs to the glycosyl hydrolase 31 family
SE86_RS05975	COG0717	Belongs to the dCTP deaminase family
SE86_RS06010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SE86_RS06030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SE86_RS06060	COG0281	malic enzyme
SE86_RS06065	COG1953	Uracil, thiamine, allantoin
SE86_RS06080	COG1175	transmembrane transport
SE86_RS06085	COG0395	ABC-type sugar transport system, permease component
SE86_RS06090	COG3842	ATPase activity
SE86_RS06100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SE86_RS06105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SE86_RS06110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SE86_RS06120	COG0200	Binds to the 23S rRNA
SE86_RS06125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SE86_RS06130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SE86_RS06140	COG0052	Belongs to the universal ribosomal protein uS2 family
SE86_RS06150	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SE86_RS06175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SE86_RS06190	COG0521	Mo-molybdopterin cofactor biosynthetic process
SE86_RS06195	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SE86_RS06210	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SE86_RS06215	COG3118	belongs to the thioredoxin family
SE86_RS06235	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SE86_RS06240	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SE86_RS06275	COG0109	protoheme IX farnesyltransferase activity
SE86_RS06280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SE86_RS06290	COG2379	hydroxypyruvate reductase
SE86_RS06295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SE86_RS06295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SE86_RS06330	COG0446	pyridine nucleotide-disulphide oxidoreductase
SE86_RS06350	COG1250	3-hydroxyacyl-CoA dehydrogenase
SE86_RS06370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SE86_RS06405	COG1960	acyl-CoA dehydrogenase activity
SE86_RS06410	COG1979	alcohol dehydrogenase
SE86_RS06425	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SE86_RS06445	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SE86_RS06470	COG1013	pyruvate-flavodoxin oxidoreductase activity
SE86_RS06475	COG0674	pyruvate-flavodoxin oxidoreductase activity
SE86_RS06480	COG1144	Oxidoreductase
SE86_RS06505	COG1201	RNA secondary structure unwinding
SE86_RS06510	COG2814	Major facilitator Superfamily
SE86_RS06515	COG0295	cytidine deaminase activity
SE86_RS06540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SE86_RS06545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SE86_RS06555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SE86_RS06555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SE86_RS06565	COG1061	Type III restriction enzyme res subunit
SE86_RS06570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SE86_RS06575	COG0045	succinate-CoA ligase (ADP-forming) activity
SE86_RS06595	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SE86_RS06595	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SE86_RS06625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SE86_RS06665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SE86_RS06670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SE86_RS06675	COG0105	UTP biosynthetic process
SE86_RS06710	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
SE86_RS06725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SE86_RS06785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SE86_RS06800	COG2239	Acts as a magnesium transporter
SE86_RS06915	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SE86_RS06920	COG1185	polyribonucleotide nucleotidyltransferase activity
SE86_RS06935	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SE86_RS06970	COG0495	leucyl-tRNA aminoacylation
SE86_RS06975	COG1418	mRNA catabolic process
SE86_RS06995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SE86_RS07010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SE86_RS07030	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SE86_RS07035	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SE86_RS07060	COG0477	Major facilitator Superfamily
SE86_RS07070	COG1252	NADH dehydrogenase
SE86_RS07110	COG0085	RNA polymerase activity
SE86_RS07120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SE86_RS07145	COG0049	tRNA binding
SE86_RS07150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SE86_RS07155	COG0051	transcription antitermination factor activity, RNA binding
SE86_RS07165	COG1793	dna ligase
SE86_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
SE86_RS07190	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SE86_RS07250	COG0303	'Molybdopterin
SE86_RS07260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SE86_RS07265	COG0181	hydroxymethylbilane synthase activity
SE86_RS07270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SE86_RS07280	COG1078	dGTPase activity
SE86_RS07285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SE86_RS07300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SE86_RS07345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SE86_RS07390	COG1980	fructose-bisphosphate aldolase activity
SE86_RS07395	COG2022	thiamine diphosphate biosynthetic process
SE86_RS07405	COG1960	acyl-CoA dehydrogenase activity
SE86_RS07410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SE86_RS07420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SE86_RS07425	COG0444	Belongs to the ABC transporter superfamily
SE86_RS07430	COG4608	Belongs to the ABC transporter superfamily
SE86_RS07460	COG1110	DNA topoisomerase II activity
SE86_RS07465	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SE86_RS07470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SE86_RS07480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SE86_RS07515	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SE86_RS07525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
SE86_RS07540	COG0351	phosphomethylpyrimidine kinase
SE86_RS07540	COG0352	thiamine-phosphate diphosphorylase activity
SE86_RS07545	COG0309	Hydrogenase expression formation protein (HypE)
SE86_RS07550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SE86_RS07575	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SE86_RS07580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SE86_RS07595	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SE86_RS07615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SE86_RS07625	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SE86_RS07630	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SE86_RS07640	COG0719	Fe-S assembly protein
SE86_RS07645	COG0396	ATPase activity
SE86_RS07670	COG1113	amino acid transport
SE86_RS07675	COG0235	Class ii aldolase
SE86_RS07705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SE86_RS07705	COG0674	pyruvate-flavodoxin oxidoreductase activity
SE86_RS07710	COG1013	pyruvate-flavodoxin oxidoreductase activity
SE86_RS07725	COG2414	aldehyde ferredoxin oxidoreductase
SE86_RS07730	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SE86_RS07740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SE86_RS07765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SE86_RS07770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SE86_RS07780	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
SE86_RS07795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SE86_RS07800	COG0252	asparaginase activity
SE86_RS07825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SE86_RS07835	COG1522	sequence-specific DNA binding