locus-tag	class	description
AFER_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AFER_RS00010	COG0592	DNA-directed DNA polymerase activity
AFER_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AFER_RS00025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AFER_RS00035	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
AFER_RS00100	COG3469	chitinase activity
AFER_RS00110	COG0617	tRNA 3'-terminal CCA addition
AFER_RS00115	COG0123	including yeast histone deacetylase and acetoin utilization protein
AFER_RS00135	COG1307	EDD domain protein, DegV family
AFER_RS00145	COG0492	ferredoxin-NADP+ reductase activity
AFER_RS00175	COG2267	carboxylic ester hydrolase activity
AFER_RS00185	COG1260	myo-inositol-1-phosphate synthase
AFER_RS00205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AFER_RS00215	COG0359	binds to the 23S rRNA
AFER_RS00220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AFER_RS00260	COG0247	lactate metabolic process
AFER_RS00260	COG2181	nitrate reductase activity
AFER_RS00265	COG0717	Belongs to the dCTP deaminase family
AFER_RS00320	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AFER_RS00375	COG0076	glutamate decarboxylase activity
AFER_RS00380	COG0537	adenosine 5'-monophosphoramidase activity
AFER_RS00390	COG1832	CoA-binding protein
AFER_RS00395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AFER_RS00405	COG0124	histidyl-tRNA synthetase
AFER_RS00415	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AFER_RS00420	COG0183	Belongs to the thiolase family
AFER_RS00425	COG0512	Glutamine amidotransferase of anthranilate synthase
AFER_RS00425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFER_RS00430	COG0515	serine threonine protein kinase
AFER_RS00435	COG0515	serine threonine protein kinase
AFER_RS00435	COG2815	serine threonine protein kinase
AFER_RS00470	COG1012	belongs to the aldehyde dehydrogenase family
AFER_RS00470	COG2030	dehydratase
AFER_RS00495	COG0077	Prephenate dehydratase
AFER_RS00500	COG1691	(AIR) carboxylase
AFER_RS00505	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AFER_RS00510	COG0657	acetylesterase activity
AFER_RS00530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AFER_RS00545	COG0183	Belongs to the thiolase family
AFER_RS00550	COG0297	glycogen (starch) synthase activity
AFER_RS00585	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AFER_RS00610	COG1850	ribulose-bisphosphate carboxylase activity
AFER_RS00635	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AFER_RS00640	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AFER_RS00645	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
AFER_RS00660	COG1192	Involved in chromosome partitioning
AFER_RS00680	COG3002	Belongs to the UPF0753 family
AFER_RS00700	COG1766	The M ring may be actively involved in energy transduction
AFER_RS00715	COG1157	protein secretion by the type III secretion system
AFER_RS00725	COG0739	heme binding
AFER_RS00725	COG0741	lytic transglycosylase activity
AFER_RS00725	COG1196	nuclear chromosome segregation
AFER_RS00740	COG1749	Flagellar hook protein flgE
AFER_RS00750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AFER_RS00755	COG1360	Flagellar Motor Protein
AFER_RS00785	COG2963	transposase activity
AFER_RS00790	COG2801	Transposase and inactivated derivatives
AFER_RS00810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFER_RS00815	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AFER_RS00830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AFER_RS00835	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFER_RS00840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AFER_RS00845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AFER_RS00855	COG0572	uridine kinase
AFER_RS00860	COG1285	pathogenesis
AFER_RS00875	COG4166	transmembrane transport
AFER_RS00885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFER_RS00900	COG0583	DNA-binding transcription factor activity
AFER_RS00905	COG3588	fructose-bisphosphate aldolase
AFER_RS00920	COG2197	response regulator
AFER_RS00960	COG2009	succinate dehydrogenase
AFER_RS00965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AFER_RS01010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFER_RS01020	COG0745	RESPONSE REGULATOR receiver
AFER_RS01025	COG5002	protein histidine kinase activity
AFER_RS01075	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AFER_RS01085	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AFER_RS01090	COG2198	Histidine kinase
AFER_RS01090	COG0643	Histidine kinase
AFER_RS01095	COG0835	chemotaxis
AFER_RS01100	COG2201	protein-glutamate methylesterase activity
AFER_RS01115	COG0745	RESPONSE REGULATOR receiver
AFER_RS01140	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFER_RS01145	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFER_RS01145	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFER_RS01155	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AFER_RS01185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFER_RS01245	COG0316	Belongs to the HesB IscA family
AFER_RS01250	COG0745	RESPONSE REGULATOR receiver
AFER_RS01255	COG0174	glutamine synthetase
AFER_RS01275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AFER_RS01275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AFER_RS01290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AFER_RS01295	COG0181	hydroxymethylbilane synthase activity
AFER_RS01310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFER_RS01315	COG0038	chloride channel
AFER_RS01330	COG1028	Short-chain dehydrogenase reductase Sdr
AFER_RS01375	COG0667	Aldo Keto reductase
AFER_RS01390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AFER_RS01395	COG1132	(ABC) transporter
AFER_RS01400	COG0778	Nitroreductase
AFER_RS01475	COG1289	transmembrane transporter activity
AFER_RS01480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AFER_RS01485	COG0513	Belongs to the DEAD box helicase family
AFER_RS01500	COG1024	Enoyl-CoA hydratase
AFER_RS01530	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AFER_RS01535	COG0393	Putative heavy-metal-binding
AFER_RS01540	COG2814	Major facilitator Superfamily
AFER_RS01560	COG2801	Transposase and inactivated derivatives
AFER_RS01565	COG2963	transposase activity
AFER_RS01575	COG1960	acyl-CoA dehydrogenase activity
AFER_RS01580	COG0215	cysteine-tRNA ligase activity
AFER_RS01585	COG0525	valine-tRNA ligase activity
AFER_RS01590	COG1914	H( )-stimulated, divalent metal cation uptake system
AFER_RS01595	COG0640	Transcriptional regulator
AFER_RS01605	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AFER_RS01610	COG1053	succinate dehydrogenase
AFER_RS01615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AFER_RS01640	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFER_RS01645	COG0045	succinate-CoA ligase (ADP-forming) activity
AFER_RS01650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AFER_RS01660	COG0138	bifunctional purine biosynthesis protein purh
AFER_RS01665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AFER_RS01670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AFER_RS01675	COG2814	Major facilitator Superfamily
AFER_RS01715	COG1131	(ABC) transporter
AFER_RS01725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AFER_RS01730	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AFER_RS01735	COG1138	Cytochrome C-type biogenesis protein
AFER_RS01740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFER_RS01750	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AFER_RS01755	COG0477	Major facilitator Superfamily
AFER_RS01760	COG2197	response regulator
AFER_RS01775	COG1131	(ABC) transporter
AFER_RS01790	COG0489	protein tyrosine kinase activity
AFER_RS01790	COG2151	metal-sulfur cluster biosynthetic enzyme
AFER_RS01820	COG2086	electron transfer activity
AFER_RS01825	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AFER_RS01835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AFER_RS01840	COG0297	glycogen (starch) synthase activity
AFER_RS01855	COG0438	transferase activity, transferring glycosyl groups
AFER_RS01860	COG0644	oxidoreductase
AFER_RS01865	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFER_RS01870	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFER_RS01875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFER_RS01880	COG0649	NAD binding
AFER_RS01895	COG1034	ATP synthesis coupled electron transport
AFER_RS01900	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AFER_RS01905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AFER_RS01910	COG0839	Belongs to the complex I subunit 6 family
AFER_RS01915	COG0713	ATP synthesis coupled electron transport
AFER_RS01920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AFER_RS01930	COG1007	ATP synthesis coupled electron transport
AFER_RS01940	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AFER_RS01940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFER_RS01945	COG1666	GTP binding
AFER_RS01965	COG1247	-acetyltransferase
AFER_RS01980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AFER_RS02000	COG0250	Participates in transcription elongation, termination and antitermination
AFER_RS02005	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AFER_RS02010	COG0081	regulation of translation
AFER_RS02015	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AFER_RS02020	COG0222	ribosome binding
AFER_RS02025	COG0085	RNA polymerase activity
AFER_RS02030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AFER_RS02035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AFER_RS02040	COG0049	tRNA binding
AFER_RS02045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AFER_RS02050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AFER_RS02055	COG0051	transcription antitermination factor activity, RNA binding
AFER_RS02060	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AFER_RS02070	COG0089	rRNA binding
AFER_RS02075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AFER_RS02080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AFER_RS02085	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AFER_RS02095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AFER_RS02100	COG0255	Belongs to the universal ribosomal protein uL29 family
AFER_RS02105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AFER_RS02110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AFER_RS02115	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AFER_RS02120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AFER_RS02125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AFER_RS02130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AFER_RS02135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AFER_RS02140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AFER_RS02145	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AFER_RS02150	COG1841	ribosomal large subunit assembly
AFER_RS02155	COG0200	Binds to the 23S rRNA
AFER_RS02165	COG0563	adenylate kinase activity
AFER_RS02175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AFER_RS02180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AFER_RS02185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AFER_RS02190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AFER_RS02200	COG0203	ribosomal protein L17
AFER_RS02210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AFER_RS02215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AFER_RS02220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFER_RS02225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AFER_RS02235	COG0583	DNA-binding transcription factor activity
AFER_RS02240	COG0736	holo-[acyl-carrier-protein] synthase activity
AFER_RS02245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AFER_RS02245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AFER_RS02250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AFER_RS02255	COG1573	uracil-dna glycosylase
AFER_RS02270	COG0456	acetyltransferase
AFER_RS02275	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AFER_RS02280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AFER_RS02285	COG0459	protein refolding
AFER_RS02340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AFER_RS02360	COG0516	GMP reductase activity
AFER_RS02365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AFER_RS02365	COG0519	Catalyzes the synthesis of GMP from XMP
AFER_RS02425	COG0312	modulator of DNA gyrase
AFER_RS02435	COG2239	Acts as a magnesium transporter
AFER_RS02440	COG1914	H( )-stimulated, divalent metal cation uptake system
AFER_RS02495	COG0303	'Molybdopterin
AFER_RS02500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AFER_RS02510	COG0438	transferase activity, transferring glycosyl groups
AFER_RS02515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AFER_RS02535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFER_RS02545	COG3387	PFAM Glycoside hydrolase 15-related
AFER_RS02555	COG1940	carbohydrate kinase activity
AFER_RS02560	COG2814	Major facilitator Superfamily
AFER_RS02585	COG0410	ABC transporter
AFER_RS02605	COG4565	transcriptional regulatory protein
AFER_RS02620	COG3290	protein histidine kinase activity
AFER_RS02630	COG2801	Transposase and inactivated derivatives
AFER_RS02650	COG2801	Transposase and inactivated derivatives
AFER_RS02665	COG1132	(ABC) transporter
AFER_RS02670	COG4988	ABC transporter
AFER_RS02675	COG1294	oxidase, subunit
AFER_RS02680	COG1271	oxidase subunit
AFER_RS02685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AFER_RS02690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFER_RS02695	COG0084	hydrolase, TatD family'
AFER_RS02700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AFER_RS02705	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AFER_RS02715	COG0012	GTP binding
AFER_RS02725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AFER_RS02740	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AFER_RS02755	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AFER_RS02770	COG0719	Fe-S assembly protein
AFER_RS02800	COG2963	transposase activity
AFER_RS02820	COG2801	Transposase and inactivated derivatives
AFER_RS02840	COG2205	protein histidine kinase activity
AFER_RS02845	COG0745	RESPONSE REGULATOR receiver
AFER_RS02850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFER_RS02855	COG1024	Enoyl-CoA hydratase
AFER_RS02865	COG2146	nitrite reductase [NAD(P)H] activity
AFER_RS02870	COG0396	ATPase activity
AFER_RS02885	COG0396	ATPase activity
AFER_RS02890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AFER_RS02895	COG0822	iron-sulfur transferase activity
AFER_RS02920	COG1929	Belongs to the glycerate kinase type-1 family
AFER_RS02925	COG1012	belongs to the aldehyde dehydrogenase family
AFER_RS02935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFER_RS02950	COG1217	gtp-binding protein TYPA
AFER_RS02975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFER_RS02995	COG2409	Drug exporters of the RND superfamily
AFER_RS03000	COG1024	Enoyl-CoA hydratase
AFER_RS03005	COG0318	PFAM AMP-dependent synthetase and ligase
AFER_RS03020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AFER_RS03055	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AFER_RS03060	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFER_RS03085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AFER_RS03095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AFER_RS03110	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AFER_RS03115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AFER_RS03185	COG0697	spore germination
AFER_RS03200	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AFER_RS03205	COG1191	sigma factor activity
AFER_RS03215	COG0052	Belongs to the universal ribosomal protein uS2 family
AFER_RS03220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AFER_RS03225	COG0528	UMP kinase activity
AFER_RS03230	COG0233	cytoplasmic translational termination
AFER_RS03240	COG4589	Belongs to the CDS family
AFER_RS03245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AFER_RS03250	COG0750	zinc metalloprotease
AFER_RS03255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AFER_RS03260	COG0442	prolyl-tRNA aminoacylation
AFER_RS03265	COG0779	Required for maturation of 30S ribosomal subunits
AFER_RS03270	COG0195	Participates in both transcription termination and antitermination
AFER_RS03280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AFER_RS03285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AFER_RS03290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AFER_RS03300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AFER_RS03305	COG1185	polyribonucleotide nucleotidyltransferase activity
AFER_RS03320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AFER_RS03325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AFER_RS03330	COG1674	ftsk spoiiie
AFER_RS03335	COG1686	Belongs to the peptidase S11 family
AFER_RS03340	COG0083	homoserine kinase activity
AFER_RS03345	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFER_RS03350	COG1546	Belongs to the CinA family
AFER_RS03350	COG1058	Belongs to the CinA family
AFER_RS03355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AFER_RS03375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AFER_RS03380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AFER_RS03385	COG0436	Aminotransferase
AFER_RS03390	COG2171	N-acyltransferase activity
AFER_RS03430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AFER_RS03445	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AFER_RS03500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFER_RS03535	COG5522	Integral membrane protein (intg_mem_TP0381)
AFER_RS03540	COG2801	Transposase and inactivated derivatives
AFER_RS03565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AFER_RS03570	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AFER_RS03595	COG0686	Belongs to the AlaDH PNT family
AFER_RS03600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFER_RS03605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AFER_RS03620	COG0745	RESPONSE REGULATOR receiver
AFER_RS03630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFER_RS03650	COG0189	ligase activity
AFER_RS03660	COG0352	thiamine-phosphate diphosphorylase activity
AFER_RS03670	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AFER_RS03675	COG0328	RNA-DNA hybrid ribonuclease activity
AFER_RS03690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AFER_RS03695	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFER_RS03700	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AFER_RS03710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AFER_RS03720	COG0646	methionine synthase
AFER_RS03720	COG1410	methionine synthase
AFER_RS03725	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AFER_RS03735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFER_RS03735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFER_RS03740	COG2154	pterin-4-alpha-carbinolamine dehydratase
AFER_RS03745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AFER_RS03755	COG4770	biotin carboxylase activity
AFER_RS03765	COG1960	acyl-CoA dehydrogenase activity
AFER_RS03780	COG1091	dTDP-4-dehydrorhamnose reductase activity
AFER_RS03795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AFER_RS03800	COG0778	Nitroreductase
AFER_RS03800	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AFER_RS03805	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AFER_RS03875	COG0494	nUDIX hydrolase
AFER_RS03875	COG0406	alpha-ribazole phosphatase activity
AFER_RS03895	COG0586	Pfam SNARE associated Golgi protein
AFER_RS03920	COG0740	serine-type endopeptidase activity
AFER_RS03925	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AFER_RS03935	COG0105	UTP biosynthetic process
AFER_RS03940	COG1077	Cell shape determining protein MreB Mrl
AFER_RS03965	COG1530	ribonuclease E activity
AFER_RS03970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AFER_RS03975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AFER_RS03980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AFER_RS03985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AFER_RS03995	COG2318	DinB family
AFER_RS04015	COG0559	Belongs to the binding-protein-dependent transport system permease family
AFER_RS04025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AFER_RS04070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AFER_RS04080	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AFER_RS04110	COG2986	histidine ammonia-lyase
AFER_RS04120	COG0318	PFAM AMP-dependent synthetase and ligase
AFER_RS04145	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AFER_RS04150	COG1797	cobyrinic acid a,c-diamide synthase activity
AFER_RS04160	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AFER_RS04185	COG3590	peptidase
AFER_RS04200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AFER_RS04205	COG1492	cobalamin metabolic process
AFER_RS04220	COG1573	uracil-dna glycosylase
AFER_RS04230	COG5001	Diguanylate cyclase
AFER_RS04230	COG3300	MHYT domain
AFER_RS04240	COG3383	formate dehydrogenase (NAD+) activity
AFER_RS04255	COG0022	dehydrogenase e1 component
AFER_RS04270	COG0427	acetyl-CoA hydrolase
AFER_RS04295	COG0596	Alpha beta hydrolase
AFER_RS04305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AFER_RS04335	COG2326	polyphosphate kinase activity
AFER_RS04345	COG2226	methyltransferase
AFER_RS04365	COG2226	methyltransferase
AFER_RS04370	COG1660	Displays ATPase and GTPase activities
AFER_RS04375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AFER_RS04380	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AFER_RS04385	COG0126	phosphoglycerate kinase activity
AFER_RS04390	COG0149	triose-phosphate isomerase activity
AFER_RS04395	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AFER_RS04415	COG2095	MarC family integral membrane protein
AFER_RS04435	COG0450	alkyl hydroperoxide reductase
AFER_RS04440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AFER_RS04455	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AFER_RS04460	COG0463	Glycosyl transferase, family 2
AFER_RS04465	COG0756	dUTP diphosphatase activity
AFER_RS04490	COG0515	serine threonine protein kinase
AFER_RS04510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFER_RS04520	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFER_RS04525	COG2376	Dihydroxyacetone kinase
AFER_RS04530	COG1461	Dihydroxyacetone kinase
AFER_RS04540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AFER_RS04555	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AFER_RS04565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFER_RS04580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AFER_RS04610	COG0647	UMP catabolic process
AFER_RS04615	COG1830	Aldolase
AFER_RS04635	COG1611	Belongs to the LOG family
AFER_RS04640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AFER_RS04670	COG1141	Ferredoxin
AFER_RS04675	COG1222	aaa ATPase
AFER_RS04680	COG4122	O-methyltransferase activity
AFER_RS04690	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFER_RS04695	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFER_RS04700	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
AFER_RS04715	COG0180	Tryptophanyl-tRNA synthetase
AFER_RS04720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFER_RS04725	COG0805	protein transport
AFER_RS04750	COG1051	belongs to the nudix hydrolase family
AFER_RS04815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AFER_RS04835	COG0436	Aminotransferase
AFER_RS04855	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AFER_RS04860	COG0343	queuine tRNA-ribosyltransferase activity
AFER_RS04870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AFER_RS04875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AFER_RS04880	COG0531	amino acid
AFER_RS04895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AFER_RS04900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AFER_RS04910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AFER_RS04920	COG0772	Belongs to the SEDS family
AFER_RS04935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AFER_RS04940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AFER_RS04950	COG0425	Belongs to the sulfur carrier protein TusA family
AFER_RS04980	COG0247	lactate metabolic process
AFER_RS04980	COG2181	nitrate reductase activity
AFER_RS04985	COG2086	electron transfer activity
AFER_RS04995	COG0247	lactate metabolic process
AFER_RS04995	COG2181	nitrate reductase activity
AFER_RS05005	COG0509	glycine decarboxylation via glycine cleavage system
AFER_RS05010	COG0509	glycine decarboxylation via glycine cleavage system
AFER_RS05015	COG2210	Belongs to the sulfur carrier protein TusA family
AFER_RS05025	COG2801	Transposase and inactivated derivatives
AFER_RS05030	COG2801	Transposase and inactivated derivatives
AFER_RS05040	COG2963	transposase activity
AFER_RS05045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AFER_RS05050	COG1518	maintenance of DNA repeat elements
AFER_RS05065	COG1857	crispr-associated protein
AFER_RS05095	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFER_RS05105	COG1609	Transcriptional regulator
AFER_RS05110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AFER_RS05115	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AFER_RS05135	COG0095	Lipoate-protein ligase
AFER_RS05145	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AFER_RS05155	COG0248	Ppx GppA phosphatase
AFER_RS05170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AFER_RS05175	COG0604	alcohol dehydrogenase
AFER_RS05190	COG0556	nucleotide-excision repair
AFER_RS05195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFER_RS05215	COG1088	dTDP-glucose 4,6-dehydratase activity
AFER_RS05255	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AFER_RS05260	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFER_RS05265	COG0318	PFAM AMP-dependent synthetase and ligase
AFER_RS05270	COG1309	transcriptional regulator
AFER_RS05275	COG1960	acyl-CoA dehydrogenase activity
AFER_RS05285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFER_RS05300	COG1024	Enoyl-CoA hydratase
AFER_RS05305	COG0531	amino acid
AFER_RS05350	COG1131	(ABC) transporter
AFER_RS05380	COG0095	Lipoate-protein ligase
AFER_RS05410	COG1136	(ABC) transporter
AFER_RS05415	COG1126	abc transporter atp-binding protein
AFER_RS05470	COG1446	asparaginase
AFER_RS05510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AFER_RS05515	COG1119	ATPase activity
AFER_RS05545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFER_RS05565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AFER_RS05570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AFER_RS05580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFER_RS05585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AFER_RS05600	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AFER_RS05605	COG0159	tryptophan synthase activity
AFER_RS05610	COG0133	tryptophan synthase activity
AFER_RS05615	COG0135	phosphoribosylanthranilate isomerase activity
AFER_RS05620	COG0134	indole-3-glycerol-phosphate synthase activity
AFER_RS05625	COG2814	Major facilitator Superfamily
AFER_RS05630	COG0745	RESPONSE REGULATOR receiver
AFER_RS05635	COG5002	protein histidine kinase activity
AFER_RS05640	COG3300	MHYT domain
AFER_RS05640	COG5001	Diguanylate cyclase
AFER_RS05655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AFER_RS05665	COG0107	imidazoleglycerol-phosphate synthase activity
AFER_RS05670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AFER_RS05675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AFER_RS05680	COG0131	Imidazoleglycerol-phosphate dehydratase
AFER_RS05685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AFER_RS05690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AFER_RS05725	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFER_RS05730	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AFER_RS05735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AFER_RS05750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AFER_RS05755	COG0509	glycine decarboxylation via glycine cleavage system
AFER_RS05760	COG1716	ATPase activity
AFER_RS05780	COG0785	Cytochrome C biogenesis protein
AFER_RS05795	COG1994	Peptidase M50
AFER_RS05800	COG4974	Belongs to the 'phage' integrase family
AFER_RS05810	COG0504	CTP synthase activity
AFER_RS05815	COG0497	DNA recombination
AFER_RS05820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AFER_RS05845	COG0601	transmembrane transport
AFER_RS05860	COG1316	TRANSCRIPTIONal
AFER_RS05865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFER_RS05880	COG0535	radical SAM domain protein
AFER_RS05885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFER_RS05895	COG0318	PFAM AMP-dependent synthetase and ligase
AFER_RS05900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AFER_RS05900	COG2022	thiamine diphosphate biosynthetic process
AFER_RS05915	COG0351	phosphomethylpyrimidine kinase
AFER_RS05920	COG3300	MHYT domain
AFER_RS05920	COG5001	Diguanylate cyclase
AFER_RS06040	COG2205	protein histidine kinase activity
AFER_RS06050	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AFER_RS06060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AFER_RS06080	COG3971	2-oxopent-4-enoate hydratase activity
AFER_RS06110	COG1570	exodeoxyribonuclease VII activity
AFER_RS06120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AFER_RS06140	COG0154	amidase activity
AFER_RS06150	COG0698	ribose 5-phosphate isomerase
AFER_RS06170	COG1959	2 iron, 2 sulfur cluster binding
AFER_RS06180	COG0386	Belongs to the glutathione peroxidase family
AFER_RS06215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AFER_RS06225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AFER_RS06235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AFER_RS06240	COG0531	amino acid
AFER_RS06250	COG2255	four-way junction helicase activity
AFER_RS06255	COG0632	four-way junction helicase activity
AFER_RS06260	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AFER_RS06265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AFER_RS06270	COG0217	transcriptional regulatory protein
AFER_RS06275	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AFER_RS06280	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AFER_RS06290	COG0438	transferase activity, transferring glycosyl groups
AFER_RS06300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AFER_RS06330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AFER_RS06335	COG0215	cysteine-tRNA ligase activity
AFER_RS06360	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AFER_RS06370	COG0762	integral membrane protein
AFER_RS06390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AFER_RS06400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AFER_RS06405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AFER_RS06415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AFER_RS06420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFER_RS06425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFER_RS06430	COG0768	penicillin binding
AFER_RS06440	COG0275	rRNA processing
AFER_RS06445	COG2001	Belongs to the MraZ family
AFER_RS06485	COG0671	phosphoesterase, PA-phosphatase related
AFER_RS06495	COG0358	DNA primase activity
AFER_RS06500	COG0574	Belongs to the PEP-utilizing enzyme family
AFER_RS06500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AFER_RS06505	COG0423	glycine-tRNA ligase activity
AFER_RS06520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AFER_RS06525	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AFER_RS06530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AFER_RS06540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AFER_RS06620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFER_RS06625	COG1584	GPR1 FUN34 yaaH family protein
AFER_RS06655	COG0484	heat shock protein binding
AFER_RS06660	COG1420	regulation of RNA biosynthetic process
AFER_RS06665	COG0268	Binds directly to 16S ribosomal RNA
AFER_RS06670	COG0481	GTPase activity
AFER_RS06700	COG0415	Belongs to the DNA photolyase family
AFER_RS06710	COG3118	belongs to the thioredoxin family
AFER_RS06715	COG0667	Aldo Keto reductase
AFER_RS06720	COG0596	Alpha beta hydrolase
AFER_RS06725	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AFER_RS06735	COG0577	efflux transmembrane transporter activity
AFER_RS06735	COG1136	(ABC) transporter
AFER_RS06760	COG2963	transposase activity
AFER_RS06765	COG2801	Transposase and inactivated derivatives
AFER_RS06775	COG2801	Transposase and inactivated derivatives
AFER_RS06780	COG2963	transposase activity
AFER_RS06785	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AFER_RS06795	COG0495	leucyl-tRNA aminoacylation
AFER_RS06830	COG0366	Alpha amylase catalytic
AFER_RS06870	COG1045	serine acetyltransferase
AFER_RS06880	COG1194	a g-specific adenine glycosylase
AFER_RS06935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AFER_RS06940	COG1160	GTP binding
AFER_RS06950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AFER_RS06965	COG0501	Belongs to the peptidase M48B family
AFER_RS06975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AFER_RS06990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AFER_RS07005	COG0247	lactate metabolic process
AFER_RS07015	COG0277	FAD linked oxidase domain protein
AFER_RS07020	COG4221	oxidoreductase activity
AFER_RS07025	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AFER_RS07040	COG0318	PFAM AMP-dependent synthetase and ligase
AFER_RS07045	COG0393	Putative heavy-metal-binding
AFER_RS07055	COG0183	Belongs to the thiolase family
AFER_RS07060	COG2050	protein possibly involved in aromatic compounds catabolism
AFER_RS07070	COG1024	Enoyl-CoA hydratase
AFER_RS07075	COG1024	Enoyl-CoA hydratase
AFER_RS07080	COG1250	3-hydroxyacyl-CoA dehydrogenase
AFER_RS07095	COG0506	proline dehydrogenase activity
AFER_RS07095	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AFER_RS07095	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AFER_RS07120	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AFER_RS07210	COG2826	transposase and inactivated derivatives, IS30 family
AFER_RS07275	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AFER_RS07290	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AFER_RS07300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AFER_RS07310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AFER_RS07315	COG1228	amidohydrolase
AFER_RS07385	COG3875	lactate racemase activity
AFER_RS07390	COG1063	alcohol dehydrogenase
AFER_RS07405	COG2271	Major facilitator Superfamily
AFER_RS07420	COG0477	Major facilitator Superfamily
AFER_RS07430	COG0640	Transcriptional regulator
AFER_RS07435	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AFER_RS07445	COG1492	cobalamin metabolic process
AFER_RS07450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AFER_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
AFER_RS07475	COG0589	response to stress
AFER_RS07480	COG2814	Major facilitator Superfamily
AFER_RS07490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AFER_RS07490	COG0493	'glutamate synthase
AFER_RS07525	COG0667	Aldo Keto reductase
AFER_RS07540	COG0154	amidase activity
AFER_RS07550	COG0513	Belongs to the DEAD box helicase family
AFER_RS07555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AFER_RS07560	COG0456	acetyltransferase
AFER_RS07565	COG1104	cysteine desulfurase activity
AFER_RS07595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AFER_RS07610	COG1960	acyl-CoA dehydrogenase activity
AFER_RS07615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AFER_RS07710	COG2814	Major facilitator Superfamily
AFER_RS07715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AFER_RS07735	COG0626	cystathionine gamma-synthase activity
AFER_RS07745	COG0335	large ribosomal subunit rRNA binding
AFER_RS07750	COG0336	Belongs to the RNA methyltransferase TrmD family
AFER_RS07755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AFER_RS07760	COG1837	Belongs to the UPF0109 family
AFER_RS07765	COG0228	four-way junction DNA binding
AFER_RS07800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AFER_RS07805	COG0571	ribonuclease III activity
AFER_RS07810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AFER_RS07830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AFER_RS07835	COG0742	ribosomal rna small subunit methyltransferase
AFER_RS07840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AFER_RS07845	COG1461	Dihydroxyacetone kinase
AFER_RS07850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AFER_RS07855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AFER_RS07870	COG2017	converts alpha-aldose to the beta-anomer
AFER_RS07895	COG1960	acyl-CoA dehydrogenase activity
AFER_RS07905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AFER_RS07915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFER_RS07925	COG0436	Aminotransferase
AFER_RS07930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AFER_RS07935	COG0066	3-isopropylmalate dehydratase activity
AFER_RS07940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AFER_RS07945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AFER_RS07950	COG0473	3-isopropylmalate dehydrogenase activity
AFER_RS07960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AFER_RS07995	COG1252	NADH dehydrogenase
AFER_RS08010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AFER_RS08025	COG0129	dihydroxy-acid dehydratase activity
AFER_RS08030	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFER_RS08035	COG0154	amidase activity
AFER_RS08040	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AFER_RS08050	COG0515	serine threonine protein kinase
AFER_RS08050	COG2815	serine threonine protein kinase
AFER_RS08055	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AFER_RS08060	COG0482	sulfurtransferase activity
AFER_RS08075	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AFER_RS08090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AFER_RS08115	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AFER_RS08115	COG3608	succinylglutamate desuccinylase aspartoacylase
AFER_RS08160	COG1172	Belongs to the binding-protein-dependent transport system permease family
AFER_RS08170	COG4213	ABC transporter substrate-binding protein
AFER_RS08190	COG1074	ATP-dependent DNA helicase activity
AFER_RS08240	COG0148	phosphopyruvate hydratase activity
AFER_RS08245	COG3956	TIGRFAM MazG family protein
AFER_RS08265	COG0193	aminoacyl-tRNA hydrolase activity
AFER_RS08270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AFER_RS08275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AFER_RS08290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AFER_RS08300	COG0028	Belongs to the TPP enzyme family
AFER_RS08310	COG2030	dehydratase
AFER_RS08325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFER_RS08340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFER_RS08350	COG0587	DNA-directed DNA polymerase activity
AFER_RS08365	COG2188	Transcriptional regulator
AFER_RS08410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AFER_RS08415	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AFER_RS08430	COG0318	PFAM AMP-dependent synthetase and ligase
AFER_RS08440	COG1028	Short-chain dehydrogenase reductase Sdr
AFER_RS08465	COG3328	transposase activity
AFER_RS08470	COG3311	Transcriptional regulator
AFER_RS08475	COG1569	PIN domain
AFER_RS08500	COG0076	glutamate decarboxylase activity
AFER_RS08505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AFER_RS08530	COG0697	spore germination
AFER_RS08585	COG2094	Belongs to the DNA glycosylase MPG family
AFER_RS08590	COG0165	Argininosuccinate lyase
AFER_RS08595	COG0137	argininosuccinate synthase activity
AFER_RS08605	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AFER_RS08610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AFER_RS08620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AFER_RS08625	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AFER_RS08650	COG1305	Transglutaminase-like
AFER_RS08665	COG0730	response to heat
AFER_RS08670	COG0072	phenylalanine-tRNA ligase activity
AFER_RS08675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AFER_RS08680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AFER_RS08685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AFER_RS08690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AFER_RS08695	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AFER_RS08710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AFER_RS08720	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFER_RS08720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AFER_RS08725	COG0307	riboflavin synthase, alpha
AFER_RS08740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AFER_RS08745	COG0242	peptide deformylase activity
AFER_RS08765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AFER_RS08775	COG1758	RNA polymerase activity
AFER_RS08780	COG0194	GDP metabolic process
AFER_RS08795	COG0167	dihydroorotate dehydrogenase activity
AFER_RS08800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AFER_RS08805	COG0505	Belongs to the CarA family
AFER_RS08810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AFER_RS08815	COG0540	Belongs to the ATCase OTCase family
AFER_RS08820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AFER_RS08835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AFER_RS08855	COG0109	protoheme IX farnesyltransferase activity
AFER_RS08860	COG0006	proline dipeptidase activity
AFER_RS08865	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AFER_RS08880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AFER_RS08890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AFER_RS08905	COG1846	Transcriptional regulator
AFER_RS08920	COG1181	Belongs to the D-alanine--D-alanine ligase family
AFER_RS08930	COG0210	DNA helicase
AFER_RS08935	COG0708	Exodeoxyribonuclease III
AFER_RS08940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AFER_RS08950	COG0567	Dehydrogenase, E1 component
AFER_RS08950	COG0508	dehydrogenase complex catalyzes the overall conversion of
AFER_RS08960	COG1597	lipid kinase activity
AFER_RS08975	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AFER_RS08985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AFER_RS08990	COG0277	FAD linked oxidase domain protein
AFER_RS09000	COG2385	sporulation resulting in formation of a cellular spore
AFER_RS09035	COG0740	serine-type endopeptidase activity
AFER_RS09045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AFER_RS09050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AFER_RS09055	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AFER_RS09065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AFER_RS09090	COG2177	Part of the ABC transporter FtsEX involved in
AFER_RS09095	COG2884	Cell division ATP-binding protein ftsE
AFER_RS09100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AFER_RS09105	COG0653	protein targeting
AFER_RS09115	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AFER_RS09120	COG2222	sugar isomerase
AFER_RS09130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AFER_RS09165	COG2801	Transposase and inactivated derivatives
AFER_RS09180	COG0366	Alpha amylase catalytic
AFER_RS09185	COG1024	Enoyl-CoA hydratase
AFER_RS09190	COG1703	isobutyryl-CoA mutase activity
AFER_RS09195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AFER_RS09225	COG0114	fumarate hydratase activity
AFER_RS09230	COG3321	synthase
AFER_RS09230	COG1028	Short-chain dehydrogenase reductase Sdr
AFER_RS09230	COG0604	alcohol dehydrogenase
AFER_RS09245	COG2267	carboxylic ester hydrolase activity
AFER_RS09250	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFER_RS09250	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AFER_RS09265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AFER_RS09270	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AFER_RS09280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AFER_RS09285	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AFER_RS09290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AFER_RS09300	COG0356	it plays a direct role in the translocation of protons across the membrane
AFER_RS09315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AFER_RS09320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AFER_RS09330	COG2890	protein-(glutamine-N5) methyltransferase activity
AFER_RS09335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AFER_RS09345	COG0254	rRNA binding
AFER_RS09355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AFER_RS09360	COG0460	homoserine dehydrogenase
AFER_RS09365	COG0019	diaminopimelate decarboxylase activity
AFER_RS09370	COG0018	arginyl-trna synthetase
AFER_RS09380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AFER_RS09385	COG1215	transferase activity, transferring glycosyl groups
AFER_RS09390	COG0586	Pfam SNARE associated Golgi protein
AFER_RS09395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AFER_RS09400	COG0604	alcohol dehydrogenase
AFER_RS09420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AFER_RS09430	COG0723	plastoquinol--plastocyanin reductase activity
AFER_RS09450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AFER_RS09460	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AFER_RS09470	COG1946	Acyl-CoA thioesterase
AFER_RS09475	COG0372	Belongs to the citrate synthase family
AFER_RS09490	COG1051	belongs to the nudix hydrolase family
AFER_RS09520	COG3253	May function as heme-dependent peroxidase
AFER_RS09525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AFER_RS09535	COG0459	protein refolding
AFER_RS09540	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AFER_RS09550	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AFER_RS09570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AFER_RS09575	COG0315	cyclic pyranopterin monophosphate synthase activity
AFER_RS09595	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AFER_RS09600	COG0446	pyridine nucleotide-disulphide oxidoreductase
AFER_RS09605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AFER_RS09675	COG1615	UPF0182 protein
AFER_RS09685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AFER_RS09690	COG0235	Class ii aldolase
AFER_RS09700	COG1846	Transcriptional regulator
AFER_RS09725	COG0538	isocitrate dehydrogenase activity
AFER_RS09740	COG0314	molybdopterin synthase activity
AFER_RS09750	COG1077	Cell shape determining protein MreB Mrl
AFER_RS09770	COG2801	Transposase and inactivated derivatives
AFER_RS09785	COG3328	transposase activity
AFER_RS09805	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AFER_RS09820	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AFER_RS09820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AFER_RS09825	COG1329	Transcriptional regulator
AFER_RS09830	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AFER_RS09850	COG0142	geranyltranstransferase activity
AFER_RS09855	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AFER_RS09860	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AFER_RS09870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AFER_RS09880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AFER_RS09885	COG0302	gtp cyclohydrolase
AFER_RS09890	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AFER_RS09910	COG1595	DNA-templated transcription, initiation
AFER_RS09925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AFER_RS09930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AFER_RS09930	COG1754	DNA topoisomerase type I activity
AFER_RS09935	COG0531	amino acid
AFER_RS09940	COG0569	domain protein
AFER_RS09970	COG3384	dioxygenase
AFER_RS10065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AFER_RS10070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AFER_RS10110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AFER_RS10115	COG0047	phosphoribosylformylglycinamidine synthase activity
AFER_RS10130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AFER_RS10135	COG0151	Belongs to the GarS family
AFER_RS10140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AFER_RS10145	COG0588	phosphoglycerate mutase activity
AFER_RS10150	COG0443	Heat shock 70 kDa protein
AFER_RS10160	COG0484	heat shock protein binding
AFER_RS10165	COG0789	Transcriptional regulator
AFER_RS10170	COG0542	response to heat
AFER_RS10185	COG0174	glutamine synthetase
AFER_RS10245	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AFER_RS10250	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AFER_RS10265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AFER_RS10270	COG0473	3-isopropylmalate dehydrogenase activity
AFER_RS10290	COG0067	glutamate synthase
AFER_RS10290	COG0069	glutamate synthase activity
AFER_RS10290	COG0070	glutamate synthase
AFER_RS10305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AFER_RS10310	COG1473	amidohydrolase
AFER_RS10325	COG0004	ammonium transporteR
AFER_RS10370	COG0277	FAD linked oxidase domain protein
AFER_RS10425	COG3046	protein related to deoxyribodipyrimidine photolyase
AFER_RS10435	COG2963	transposase activity
AFER_RS10440	COG1487	ribonuclease activity
AFER_RS10455	COG0590	tRNA wobble adenosine to inosine editing
AFER_RS10475	COG3384	dioxygenase
AFER_RS10490	COG1414	Transcriptional regulator
AFER_RS10495	COG0402	S-adenosylhomocysteine deaminase activity
AFER_RS10525	COG1192	Involved in chromosome partitioning
AFER_RS10560	COG0594	ribonuclease P activity
AFER_RS10565	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AFER_RS10605	COG3409	Peptidoglycan-binding domain 1 protein
AFER_RS10605	COG0860	N-Acetylmuramoyl-L-alanine amidase
AFER_RS10630	COG3328	transposase activity
AFER_RS10650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AFER_RS10665	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AFER_RS10690	COG1652	LysM domain
AFER_RS10695	COG4786	Flagellar basal body rod
AFER_RS10715	COG2902	Dehydrogenase
AFER_RS10735	COG1309	transcriptional regulator
AFER_RS10740	COG3088	subunit of a heme lyase
AFER_RS10750	COG0101	tRNA pseudouridine synthase activity
AFER_RS10760	COG0494	nUDIX hydrolase
AFER_RS10770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFER_RS10775	COG2135	peptidase activity
AFER_RS10795	COG0719	Fe-S assembly protein
AFER_RS10810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AFER_RS10820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AFER_RS10865	COG0840	transmembrane signaling receptor activity
AFER_RS10870	COG1937	Protein conserved in bacteria
AFER_RS10895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFER_RS10900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AFER_RS10905	COG1169	isochorismate synthase
AFER_RS10915	COG0463	Glycosyl transferase, family 2
AFER_RS10925	COG0363	glucosamine-6-phosphate deaminase activity
AFER_RS10940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AFER_RS11050	COG1799	cell septum assembly
AFER_RS11055	COG1496	oxidoreductase activity
AFER_RS11060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AFER_RS11065	COG0772	Belongs to the SEDS family
AFER_RS11105	COG0277	FAD linked oxidase domain protein
AFER_RS11135	COG2826	transposase and inactivated derivatives, IS30 family
AFER_RS11145	COG2200	EAL domain
AFER_RS11150	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AFER_RS11165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AFER_RS11180	COG5002	protein histidine kinase activity
AFER_RS11180	COG5001	Diguanylate cyclase
AFER_RS11195	COG1196	nuclear chromosome segregation
AFER_RS11215	COG1129	ABC transporter
AFER_RS11265	COG3328	transposase activity
AFER_RS11285	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AFER_RS11290	COG2199	diguanylate cyclase activity
AFER_RS11290	COG2200	EAL domain
AFER_RS11290	COG2202	Pas domain
AFER_RS11295	COG2267	carboxylic ester hydrolase activity
AFER_RS11330	COG0037	tRNA processing
AFER_RS11340	COG0215	cysteine-tRNA ligase activity
AFER_RS11350	COG1216	Glycosyl transferase, family 2
AFER_RS11350	COG0438	transferase activity, transferring glycosyl groups
AFER_RS11370	COG3979	chitinase
AFER_RS11375	COG0357	Ribosomal RNA small subunit methyltransferase G
AFER_RS11380	COG1847	R3H domain protein