locus-tag	class	description
PACID_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PACID_RS00010	COG0577	efflux transmembrane transporter activity
PACID_RS00010	COG1136	(ABC) transporter
PACID_RS00015	COG1136	(ABC) transporter
PACID_RS00015	COG0577	efflux transmembrane transporter activity
PACID_RS00020	COG0592	DNA-directed DNA polymerase activity
PACID_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PACID_RS00035	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
PACID_RS00045	COG0187	DNA topoisomerase II activity
PACID_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PACID_RS00055	COG3266	domain, Protein
PACID_RS00060	COG0673	inositol 2-dehydrogenase activity
PACID_RS00065	COG1609	Transcriptional regulator
PACID_RS00070	COG1129	ABC transporter
PACID_RS00075	COG1172	Belongs to the binding-protein-dependent transport system permease family
PACID_RS00085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PACID_RS00090	COG1869	D-ribose catabolic process
PACID_RS00130	COG1396	sequence-specific DNA binding
PACID_RS00170	COG0039	L-malate dehydrogenase activity
PACID_RS00185	COG0281	malic enzyme
PACID_RS00190	COG0039	L-malate dehydrogenase activity
PACID_RS00195	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PACID_RS00220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PACID_RS00280	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
PACID_RS00290	COG0714	Associated with various cellular activities
PACID_RS00345	COG3328	transposase activity
PACID_RS00365	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
PACID_RS00380	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PACID_RS00385	COG4139	cobalamin transport
PACID_RS00405	COG0726	polysaccharide deacetylase
PACID_RS00425	COG1063	alcohol dehydrogenase
PACID_RS00430	COG3414	Phosphotransferase system galactitol-specific IIB component
PACID_RS00435	COG3775	system Galactitol-specific IIC component
PACID_RS00460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PACID_RS00465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PACID_RS00485	COG1131	(ABC) transporter
PACID_RS00495	COG0095	Lipoate-protein ligase
PACID_RS00505	COG0765	amino acid transport
PACID_RS00510	COG1126	abc transporter atp-binding protein
PACID_RS00515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PACID_RS00525	COG1653	transport
PACID_RS00530	COG1175	transmembrane transport
PACID_RS00535	COG0395	ABC-type sugar transport system, permease component
PACID_RS00540	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
PACID_RS00560	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PACID_RS00625	COG1012	belongs to the aldehyde dehydrogenase family
PACID_RS00640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PACID_RS00670	COG2759	Belongs to the formate--tetrahydrofolate ligase family
PACID_RS00695	COG1136	(ABC) transporter
PACID_RS00700	COG2197	response regulator
PACID_RS00710	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PACID_RS00715	COG3657	addiction module killer protein
PACID_RS00720	COG1690	Belongs to the RtcB family
PACID_RS00725	COG0477	Major facilitator Superfamily
PACID_RS00730	COG1132	(ABC) transporter
PACID_RS00750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PACID_RS00760	COG2205	protein histidine kinase activity
PACID_RS00765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PACID_RS00770	COG4585	Histidine kinase
PACID_RS00780	COG5002	protein histidine kinase activity
PACID_RS00785	COG0745	RESPONSE REGULATOR receiver
PACID_RS00795	COG2132	Multicopper oxidase
PACID_RS00825	COG0175	sulfate reduction
PACID_RS00840	COG0730	response to heat
PACID_RS00855	COG1473	amidohydrolase
PACID_RS00865	COG0656	L-ascorbic acid biosynthetic process
PACID_RS00900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PACID_RS00905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PACID_RS00905	COG0596	Alpha beta hydrolase
PACID_RS00915	COG2022	thiamine diphosphate biosynthetic process
PACID_RS00930	COG1472	Belongs to the glycosyl hydrolase 3 family
PACID_RS00935	COG1309	transcriptional regulator
PACID_RS00940	COG2409	Drug exporters of the RND superfamily
PACID_RS00950	COG0438	transferase activity, transferring glycosyl groups
PACID_RS00960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PACID_RS00965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PACID_RS00975	COG2814	Major facilitator Superfamily
PACID_RS00985	COG0477	Major facilitator Superfamily
PACID_RS00990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PACID_RS00995	COG1914	H( )-stimulated, divalent metal cation uptake system
PACID_RS01000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PACID_RS01000	COG1321	iron dependent repressor
PACID_RS01015	COG0281	malic enzyme
PACID_RS01035	COG1254	Belongs to the acylphosphatase family
PACID_RS01045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PACID_RS01065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PACID_RS01075	COG1136	(ABC) transporter
PACID_RS01100	COG0205	6-phosphofructokinase activity
PACID_RS01140	COG3189	MarR family transcriptional regulator
PACID_RS01150	COG2217	Heavy metal translocating P-type atpase
PACID_RS01160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PACID_RS01165	COG0783	Belongs to the Dps family
PACID_RS01220	COG0435	Glutathione S-transferase
PACID_RS01235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PACID_RS01240	COG0601	transmembrane transport
PACID_RS01270	COG2337	Toxic component of a toxin-antitoxin (TA) module
PACID_RS01280	COG1151	hydroxylamine reductase activity
PACID_RS01285	COG0633	Ferredoxin
PACID_RS01285	COG0543	2 iron, 2 sulfur cluster binding
PACID_RS01290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PACID_RS01305	COG2801	Transposase and inactivated derivatives
PACID_RS01320	COG1140	nitrate reductase beta subunit
PACID_RS01340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PACID_RS01350	COG0314	molybdopterin synthase activity
PACID_RS01360	COG0315	cyclic pyranopterin monophosphate synthase activity
PACID_RS01365	COG0315	cyclic pyranopterin monophosphate synthase activity
PACID_RS01365	COG0521	Mo-molybdopterin cofactor biosynthetic process
PACID_RS01375	COG0352	thiamine-phosphate diphosphorylase activity
PACID_RS01375	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PACID_RS01375	COG0351	phosphomethylpyrimidine kinase
PACID_RS01380	COG0352	thiamine-phosphate diphosphorylase activity
PACID_RS01385	COG3386	PFAM SMP-30 Gluconolaconase
PACID_RS01400	COG1172	Belongs to the binding-protein-dependent transport system permease family
PACID_RS01405	COG1172	Belongs to the binding-protein-dependent transport system permease family
PACID_RS01410	COG1129	ABC transporter
PACID_RS01420	COG1609	Transcriptional regulator
PACID_RS01425	COG3942	CHAP domain
PACID_RS01450	COG1012	belongs to the aldehyde dehydrogenase family
PACID_RS01460	COG1609	Transcriptional regulator
PACID_RS01465	COG1904	glucuronate isomerase
PACID_RS01470	COG0246	Mannitol dehydrogenase
PACID_RS01475	COG1312	Catalyzes the dehydration of D-mannonate
PACID_RS01485	COG0656	L-ascorbic acid biosynthetic process
PACID_RS01495	COG4948	Mandelate Racemase Muconate Lactonizing
PACID_RS01515	COG1285	pathogenesis
PACID_RS01525	COG1609	Transcriptional regulator
PACID_RS01530	COG0584	glycerophosphoryl diester phosphodiesterase
PACID_RS01575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PACID_RS01585	COG1201	RNA secondary structure unwinding
PACID_RS01610	COG3415	Transposase
PACID_RS01610	COG2801	Transposase and inactivated derivatives
PACID_RS01615	COG3328	transposase activity
PACID_RS01640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PACID_RS01640	COG0519	Catalyzes the synthesis of GMP from XMP
PACID_RS01690	COG1070	Carbohydrate kinase
PACID_RS01725	COG1136	(ABC) transporter
PACID_RS01730	COG0577	efflux transmembrane transporter activity
PACID_RS01730	COG1136	(ABC) transporter
PACID_RS01745	COG0641	radical SAM
PACID_RS01750	COG3119	arylsulfatase activity
PACID_RS01785	COG1482	cell wall glycoprotein biosynthetic process
PACID_RS01790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PACID_RS01795	COG0800	Aldolase
PACID_RS01800	COG1414	Transcriptional regulator
PACID_RS01805	COG1609	Transcriptional regulator
PACID_RS01815	COG2721	sulfolactate sulfo-lyase activity
PACID_RS01820	COG1904	glucuronate isomerase
PACID_RS01855	COG1904	glucuronate isomerase
PACID_RS01860	COG0246	Mannitol dehydrogenase
PACID_RS01885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PACID_RS01890	COG2826	transposase and inactivated derivatives, IS30 family
PACID_RS01915	COG3328	transposase activity
PACID_RS01930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PACID_RS01980	COG2211	Major facilitator Superfamily
PACID_RS02010	COG5564	TIM-barrel signal transduction protein
PACID_RS02020	COG2186	Transcriptional regulator
PACID_RS02040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PACID_RS02055	COG1119	ATPase activity
PACID_RS02065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PACID_RS02075	COG0586	Pfam SNARE associated Golgi protein
PACID_RS02080	COG1063	alcohol dehydrogenase
PACID_RS02095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PACID_RS02130	COG1253	flavin adenine dinucleotide binding
PACID_RS02165	COG2072	flavoprotein involved in K transport
PACID_RS02190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PACID_RS02230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PACID_RS02250	COG0463	Glycosyl transferase, family 2
PACID_RS02265	COG0438	transferase activity, transferring glycosyl groups
PACID_RS02270	COG0438	transferase activity, transferring glycosyl groups
PACID_RS02275	COG0438	transferase activity, transferring glycosyl groups
PACID_RS02310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PACID_RS02340	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
PACID_RS02340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PACID_RS02340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PACID_RS02345	COG1105	Belongs to the carbohydrate kinase PfkB family
PACID_RS02355	COG0765	amino acid transport
PACID_RS02360	COG0765	amino acid transport
PACID_RS02365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PACID_RS02370	COG1126	abc transporter atp-binding protein
PACID_RS02375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PACID_RS02445	COG1643	Atp-dependent helicase
PACID_RS02460	COG2094	Belongs to the DNA glycosylase MPG family
PACID_RS02480	COG1846	Transcriptional regulator
PACID_RS02485	COG0386	Belongs to the glutathione peroxidase family
PACID_RS02490	COG0492	ferredoxin-NADP+ reductase activity
PACID_RS02495	COG3118	belongs to the thioredoxin family
PACID_RS02500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PACID_RS02500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PACID_RS02505	COG0305	Participates in initiation and elongation during chromosome replication
PACID_RS02510	COG1937	Protein conserved in bacteria
PACID_RS02525	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PACID_RS02535	COG0167	dihydroorotate dehydrogenase activity
PACID_RS02540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
PACID_RS02540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PACID_RS02540	COG1013	pyruvate-flavodoxin oxidoreductase activity
PACID_RS02540	COG0674	pyruvate-flavodoxin oxidoreductase activity
PACID_RS02555	COG2186	Transcriptional regulator
PACID_RS02560	COG1620	l-lactate permease
PACID_RS02565	COG0247	lactate metabolic process
PACID_RS02570	COG1139	Iron-sulfur cluster binding protein
PACID_RS02575	COG1556	Lactate utilization protein
PACID_RS02580	COG1132	(ABC) transporter
PACID_RS02585	COG4988	ABC transporter
PACID_RS02590	COG1294	oxidase, subunit
PACID_RS02595	COG1271	oxidase subunit
PACID_RS02605	COG2197	response regulator
PACID_RS02640	COG1454	alcohol dehydrogenase
PACID_RS02655	COG0395	ABC-type sugar transport system, permease component
PACID_RS02665	COG2801	Transposase and inactivated derivatives
PACID_RS02670	COG1609	Transcriptional regulator
PACID_RS02690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PACID_RS02715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PACID_RS02720	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PACID_RS02725	COG2186	Transcriptional regulator
PACID_RS02745	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PACID_RS02750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PACID_RS02755	COG1301	dicarboxylic acid transport
PACID_RS02760	COG1953	Uracil, thiamine, allantoin
PACID_RS02770	COG0393	Putative heavy-metal-binding
PACID_RS02775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PACID_RS02795	COG0515	serine threonine protein kinase
PACID_RS02800	COG0768	penicillin binding
PACID_RS02815	COG1716	ATPase activity
PACID_RS02820	COG1716	ATPase activity
PACID_RS02830	COG1088	dTDP-glucose 4,6-dehydratase activity
PACID_RS02835	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PACID_RS02845	COG3408	Glycogen debranching enzyme
PACID_RS02850	COG0604	alcohol dehydrogenase
PACID_RS02870	COG1316	TRANSCRIPTIONal
PACID_RS02895	COG0477	Major facilitator Superfamily
PACID_RS02900	COG1695	Transcriptional regulator
PACID_RS02905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PACID_RS02915	COG1113	amino acid transport
PACID_RS02920	COG1309	transcriptional regulator
PACID_RS02925	COG1131	(ABC) transporter
PACID_RS02965	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PACID_RS02970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PACID_RS02995	COG1136	(ABC) transporter
PACID_RS02995	COG0577	efflux transmembrane transporter activity
PACID_RS03010	COG0561	phosphatase activity
PACID_RS03015	COG0561	phosphatase activity
PACID_RS03020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PACID_RS03050	COG2801	Transposase and inactivated derivatives
PACID_RS03065	COG2814	Major facilitator Superfamily
PACID_RS03070	COG0583	DNA-binding transcription factor activity
PACID_RS03090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PACID_RS03095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PACID_RS03110	COG0667	Aldo Keto reductase
PACID_RS03130	COG1881	PFAM PEBP family protein
PACID_RS03140	COG4581	dead DEAH box helicase
PACID_RS03150	COG0166	Belongs to the GPI family
PACID_RS03165	COG2814	Major facilitator Superfamily
PACID_RS03170	COG0656	L-ascorbic acid biosynthetic process
PACID_RS03175	COG0018	arginyl-trna synthetase
PACID_RS03195	COG2814	Major facilitator Superfamily
PACID_RS03210	COG1012	belongs to the aldehyde dehydrogenase family
PACID_RS03220	COG1070	Carbohydrate kinase
PACID_RS03225	COG4952	isomerase
PACID_RS03230	COG2814	Major facilitator Superfamily
PACID_RS03240	COG1609	Transcriptional regulator
PACID_RS03280	COG1609	Transcriptional regulator
PACID_RS03290	COG0601	transmembrane transport
PACID_RS03305	COG1027	Aspartate ammonia-lyase
PACID_RS03335	COG0477	Major facilitator Superfamily
PACID_RS03340	COG1309	transcriptional regulator
PACID_RS03350	COG0154	amidase activity
PACID_RS03355	COG4608	Belongs to the ABC transporter superfamily
PACID_RS03370	COG1131	(ABC) transporter
PACID_RS03375	COG1309	transcriptional regulator
PACID_RS03390	COG1653	transport
PACID_RS03400	COG0395	ABC-type sugar transport system, permease component
PACID_RS03415	COG0676	glucose-6-phosphate 1-epimerase activity
PACID_RS03420	COG3830	Belongs to the UPF0237 family
PACID_RS03420	COG0560	Phosphoserine phosphatase
PACID_RS03425	COG2813	Specifically methylates the guanine in position
PACID_RS03430	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PACID_RS03435	COG0574	Belongs to the PEP-utilizing enzyme family
PACID_RS03435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PACID_RS03450	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PACID_RS03455	COG2205	protein histidine kinase activity
PACID_RS03460	COG0745	RESPONSE REGULATOR receiver
PACID_RS03480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PACID_RS03485	COG0484	heat shock protein binding
PACID_RS03490	COG0789	Transcriptional regulator
PACID_RS03495	COG1063	alcohol dehydrogenase
PACID_RS03500	COG3527	Alpha-acetolactate decarboxylase
PACID_RS03505	COG2985	domain, Protein
PACID_RS03505	COG0569	domain protein
PACID_RS03510	COG1113	amino acid transport
PACID_RS03525	COG4591	ABC-type transport system involved in lipoprotein release permease component
PACID_RS03525	COG1136	(ABC) transporter
PACID_RS03535	COG2197	response regulator
PACID_RS03540	COG4585	Histidine kinase
PACID_RS03555	COG3588	fructose-bisphosphate aldolase
PACID_RS03560	COG1609	Transcriptional regulator
PACID_RS03570	COG2211	Major facilitator Superfamily
PACID_RS03570	COG2190	(PTS) system
PACID_RS03585	COG0395	ABC-type sugar transport system, permease component
PACID_RS03595	COG0542	response to heat
PACID_RS03600	COG0395	ABC-type sugar transport system, permease component
PACID_RS03605	COG1175	transmembrane transport
PACID_RS03615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PACID_RS03625	COG1486	melibiose metabolic process
PACID_RS03640	COG1511	domain protein
PACID_RS03655	COG0702	epimerase
PACID_RS03670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PACID_RS03680	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PACID_RS03715	COG3012	SEC-C Motif Domain Protein
PACID_RS03720	COG4175	Glycine betaine
PACID_RS03720	COG0517	IMP dehydrogenase activity
PACID_RS03725	COG4176	ABC-type proline glycine betaine transport system permease component
PACID_RS03740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PACID_RS03745	COG1131	(ABC) transporter
PACID_RS03760	COG1174	glycine betaine transport
PACID_RS03770	COG1174	glycine betaine transport
PACID_RS03780	COG1012	belongs to the aldehyde dehydrogenase family
PACID_RS03785	COG0436	Aminotransferase
PACID_RS03805	COG1704	LemA family
PACID_RS03810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PACID_RS03810	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PACID_RS03830	COG0438	transferase activity, transferring glycosyl groups
PACID_RS03840	COG0438	transferase activity, transferring glycosyl groups
PACID_RS03850	COG2244	polysaccharide biosynthetic process
PACID_RS03855	COG0489	protein tyrosine kinase activity
PACID_RS03875	COG0586	Pfam SNARE associated Golgi protein
PACID_RS03890	COG0191	fructose-bisphosphate aldolase activity
PACID_RS03920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PACID_RS03925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PACID_RS03930	COG0588	phosphoglycerate mutase activity
PACID_RS03935	COG0704	Plays a role in the regulation of phosphate uptake
PACID_RS03940	COG5002	protein histidine kinase activity
PACID_RS03955	COG2801	Transposase and inactivated derivatives
PACID_RS03960	COG1329	Transcriptional regulator
PACID_RS03965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PACID_RS03975	COG3775	system Galactitol-specific IIC component
PACID_RS03985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PACID_RS04000	COG3732	PTS system glucitol sorbitol-specific
PACID_RS04020	COG1063	alcohol dehydrogenase
PACID_RS04025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PACID_RS04050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PACID_RS04055	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PACID_RS04075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PACID_RS04085	COG2814	Major facilitator Superfamily
PACID_RS04095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PACID_RS04100	COG0215	cysteine-tRNA ligase activity
PACID_RS04115	COG0626	cystathionine gamma-synthase activity
PACID_RS04170	COG3842	ATPase activity
PACID_RS04200	COG1760	l-serine dehydratase
PACID_RS04205	COG1940	carbohydrate kinase activity
PACID_RS04210	COG1653	transport
PACID_RS04215	COG1175	transmembrane transport
PACID_RS04220	COG0395	ABC-type sugar transport system, permease component
PACID_RS04225	COG1063	alcohol dehydrogenase
PACID_RS04230	COG0156	8-amino-7-oxononanoate synthase activity
PACID_RS04240	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PACID_RS04245	COG1131	(ABC) transporter
PACID_RS04255	COG4585	Histidine kinase
PACID_RS04260	COG2197	response regulator
PACID_RS04270	COG0406	alpha-ribazole phosphatase activity
PACID_RS04290	COG4585	Histidine kinase
PACID_RS04300	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PACID_RS04305	COG1492	cobalamin metabolic process
PACID_RS04325	COG1648	precorrin-2 dehydrogenase activity
PACID_RS04325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PACID_RS04340	COG0310	cobalt ion transport
PACID_RS04365	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
PACID_RS04370	COG1797	cobyrinic acid a,c-diamide synthase activity
PACID_RS04375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PACID_RS04375	COG1648	precorrin-2 dehydrogenase activity
PACID_RS04385	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PACID_RS04415	COG1854	S-ribosylhomocysteine lyase activity
PACID_RS04420	COG1482	cell wall glycoprotein biosynthetic process
PACID_RS04475	COG0363	glucosamine-6-phosphate deaminase activity
PACID_RS04480	COG1278	Cold shock
PACID_RS04495	COG2252	PERMEase
PACID_RS04520	COG1321	iron dependent repressor
PACID_RS04530	COG3118	belongs to the thioredoxin family
PACID_RS04535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PACID_RS04540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PACID_RS04550	COG3718	enzyme involved in inositol metabolism
PACID_RS04555	COG3962	Belongs to the TPP enzyme family
PACID_RS04570	COG0673	inositol 2-dehydrogenase activity
PACID_RS04575	COG2814	Major facilitator Superfamily
PACID_RS04580	COG0673	inositol 2-dehydrogenase activity
PACID_RS04600	COG1970	mechanosensitive ion channel activity
PACID_RS04615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PACID_RS04660	COG0436	Aminotransferase
PACID_RS04675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PACID_RS04700	COG1053	succinate dehydrogenase
PACID_RS04705	COG1309	transcriptional regulator
PACID_RS04730	COG0789	Transcriptional regulator
PACID_RS04740	COG0693	protein deglycase activity
PACID_RS04770	COG0657	acetylesterase activity
PACID_RS04795	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PACID_RS04800	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PACID_RS04810	COG2233	PERMEase
PACID_RS04825	COG0084	hydrolase, TatD family'
PACID_RS04830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PACID_RS04835	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PACID_RS04840	COG1846	Transcriptional regulator
PACID_RS04845	COG1309	transcriptional regulator
PACID_RS04855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PACID_RS04860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PACID_RS04865	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PACID_RS04870	COG0193	aminoacyl-tRNA hydrolase activity
PACID_RS04890	COG0148	phosphopyruvate hydratase activity
PACID_RS04920	COG2837	iron assimilation
PACID_RS04925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PACID_RS04975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PACID_RS04980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PACID_RS04985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PACID_RS04990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PACID_RS05000	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PACID_RS05005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PACID_RS05005	COG0072	phenylalanine-tRNA ligase activity
PACID_RS05010	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PACID_RS05025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PACID_RS05060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PACID_RS05065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PACID_RS05080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PACID_RS05095	COG1331	Highly conserved protein containing a thioredoxin domain
PACID_RS05100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PACID_RS05110	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PACID_RS05120	COG1722	exodeoxyribonuclease VII activity
PACID_RS05125	COG1570	exodeoxyribonuclease VII activity
PACID_RS05130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PACID_RS05135	COG1322	Protein conserved in bacteria
PACID_RS05140	COG1362	aminopeptidase activity
PACID_RS05145	COG1136	(ABC) transporter
PACID_RS05145	COG0577	efflux transmembrane transporter activity
PACID_RS05160	COG0012	GTP binding
PACID_RS05165	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PACID_RS05175	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PACID_RS05240	COG3549	Plasmid maintenance system killer
PACID_RS05265	COG3559	Exporter of polyketide antibiotics
PACID_RS05270	COG1131	(ABC) transporter
PACID_RS05280	COG3549	Plasmid maintenance system killer
PACID_RS05335	COG3328	transposase activity
PACID_RS05355	COG1397	ADP-ribosylglycohydrolase
PACID_RS05370	COG1132	(ABC) transporter
PACID_RS05375	COG0406	alpha-ribazole phosphatase activity
PACID_RS05395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PACID_RS05400	COG1335	isochorismatase
PACID_RS05430	COG0477	Major facilitator Superfamily
PACID_RS05435	COG0477	Major facilitator Superfamily
PACID_RS05460	COG2716	regulation of RNA biosynthetic process
PACID_RS05465	COG2133	pyrroloquinoline quinone binding
PACID_RS05480	COG0833	amino acid
PACID_RS05515	COG2501	S4 domain
PACID_RS05535	COG0765	amino acid transport
PACID_RS05565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PACID_RS05570	COG1121	(ABC) transporter
PACID_RS05590	COG1012	belongs to the aldehyde dehydrogenase family
PACID_RS05595	COG1063	alcohol dehydrogenase
PACID_RS05600	COG2376	Dihydroxyacetone kinase
PACID_RS05605	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
PACID_RS05610	COG1349	DNA-binding transcription factor activity
PACID_RS05615	COG0698	ribose 5-phosphate isomerase
PACID_RS05625	COG0647	UMP catabolic process
PACID_RS05635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PACID_RS05675	COG2814	Major facilitator Superfamily
PACID_RS05680	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
PACID_RS05685	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
PACID_RS05690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PACID_RS05695	COG2720	vancomycin resistance protein
PACID_RS05720	COG2171	N-acyltransferase activity
PACID_RS05730	COG1611	Belongs to the LOG family
PACID_RS05740	COG0297	glycogen (starch) synthase activity
PACID_RS05745	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PACID_RS05775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PACID_RS05780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PACID_RS05815	COG0006	proline dipeptidase activity
PACID_RS05830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PACID_RS05835	COG0531	amino acid
PACID_RS05850	COG0598	Magnesium transport protein CorA
PACID_RS05875	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PACID_RS05885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PACID_RS05900	COG3093	addiction module antidote protein HigA
PACID_RS05910	COG0174	glutamine synthetase
PACID_RS05930	COG0586	Pfam SNARE associated Golgi protein
PACID_RS05935	COG2239	Acts as a magnesium transporter
PACID_RS05940	COG0488	(ABC) transporter
PACID_RS05950	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PACID_RS05965	COG0321	lipoyl(octanoyl) transferase activity
PACID_RS05970	COG0508	dehydrogenase complex catalyzes the overall conversion of
PACID_RS06010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PACID_RS06035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PACID_RS06040	COG0723	plastoquinol--plastocyanin reductase activity
PACID_RS06045	COG2010	Cytochrome c
PACID_RS06050	COG1845	cytochrome c oxidase, subunit III
PACID_RS06060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PACID_RS06100	COG2801	Transposase and inactivated derivatives
PACID_RS06110	COG1940	carbohydrate kinase activity
PACID_RS06130	COG2197	response regulator
PACID_RS06135	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PACID_RS06160	COG0352	thiamine-phosphate diphosphorylase activity
PACID_RS06165	COG0142	geranyltranstransferase activity
PACID_RS06170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PACID_RS06175	COG0210	DNA helicase
PACID_RS06195	COG1116	anion transmembrane transporter activity
PACID_RS06195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PACID_RS06200	COG0596	Alpha beta hydrolase
PACID_RS06210	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PACID_RS06220	COG3265	gluconokinase activity
PACID_RS06240	COG1131	(ABC) transporter
PACID_RS06245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PACID_RS06245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PACID_RS06250	COG0509	glycine decarboxylation via glycine cleavage system
PACID_RS06255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PACID_RS06275	COG0714	Associated with various cellular activities
PACID_RS06280	COG2001	Belongs to the MraZ family
PACID_RS06285	COG0275	rRNA processing
PACID_RS06295	COG0768	penicillin binding
PACID_RS06305	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PACID_RS06310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PACID_RS06315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PACID_RS06320	COG0772	Belongs to the SEDS family
PACID_RS06325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PACID_RS06330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PACID_RS06335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PACID_RS06340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PACID_RS06350	COG1799	cell septum assembly
PACID_RS06380	COG0469	pyruvate kinase activity
PACID_RS06395	COG2050	protein possibly involved in aromatic compounds catabolism
PACID_RS06420	COG0539	negative regulation of cytoplasmic translation
PACID_RS06425	COG0237	dephospho-CoA kinase activity
PACID_RS06440	COG0556	nucleotide-excision repair
PACID_RS06455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PACID_RS06475	COG0322	excinuclease ABC activity
PACID_RS06480	COG1660	Displays ATPase and GTPase activities
PACID_RS06490	COG1481	regulation of sporulation
PACID_RS06495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PACID_RS06500	COG0126	phosphoglycerate kinase activity
PACID_RS06505	COG0149	triose-phosphate isomerase activity
PACID_RS06510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PACID_RS06520	COG0285	dihydrofolate synthase activity
PACID_RS06530	COG0105	UTP biosynthetic process
PACID_RS06540	COG1472	Belongs to the glycosyl hydrolase 3 family
PACID_RS06550	COG1530	ribonuclease E activity
PACID_RS06555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PACID_RS06560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PACID_RS06570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PACID_RS06575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PACID_RS06580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PACID_RS06585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PACID_RS06625	COG1280	lysine exporter protein (LysE YggA)
PACID_RS06665	COG0488	(ABC) transporter
PACID_RS06740	COG0590	tRNA wobble adenosine to inosine editing
PACID_RS06750	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PACID_RS06765	COG0495	leucyl-tRNA aminoacylation
PACID_RS06775	COG2333	competence protein COMEC
PACID_RS06775	COG0658	competence protein
PACID_RS06780	COG1061	Type III restriction enzyme res subunit
PACID_RS06790	COG0268	Binds directly to 16S ribosomal RNA
PACID_RS06800	COG0481	GTPase activity
PACID_RS06820	COG4948	Mandelate Racemase Muconate Lactonizing
PACID_RS06825	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PACID_RS06830	COG1169	isochorismate synthase
PACID_RS06840	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PACID_RS06850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PACID_RS06855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PACID_RS06865	COG1131	(ABC) transporter
PACID_RS06870	COG1309	transcriptional regulator
PACID_RS06875	COG0477	Major facilitator Superfamily
PACID_RS06885	COG0395	ABC-type sugar transport system, permease component
PACID_RS06890	COG1175	transmembrane transport
PACID_RS06910	COG0483	inositol monophosphate 1-phosphatase activity
PACID_RS06930	COG1420	regulation of RNA biosynthetic process
PACID_RS06935	COG0484	heat shock protein binding
PACID_RS06945	COG1063	alcohol dehydrogenase
PACID_RS06950	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PACID_RS06950	COG2213	PTS system mannitol-specific
PACID_RS06965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PACID_RS06970	COG5006	permease, DMT superfamily
PACID_RS06975	COG0343	queuine tRNA-ribosyltransferase activity
PACID_RS06985	COG2197	response regulator
PACID_RS06990	COG4152	abc transporter atp-binding protein
PACID_RS07030	COG2226	methyltransferase
PACID_RS07050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PACID_RS07060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PACID_RS07070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PACID_RS07075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PACID_RS07080	COG0765	amino acid transport
PACID_RS07085	COG0765	amino acid transport
PACID_RS07100	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PACID_RS07115	COG1381	Involved in DNA repair and RecF pathway recombination
PACID_RS07125	COG4716	Myosin-crossreactive antigen
PACID_RS07155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PACID_RS07300	COG2801	Transposase and inactivated derivatives
PACID_RS07320	COG0714	Associated with various cellular activities
PACID_RS07330	COG2304	oxidoreductase activity
PACID_RS07355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PACID_RS07360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PACID_RS07370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PACID_RS07385	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PACID_RS07395	COG0667	Aldo Keto reductase
PACID_RS07410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PACID_RS07415	COG0505	Belongs to the CarA family
PACID_RS07420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PACID_RS07425	COG0543	2 iron, 2 sulfur cluster binding
PACID_RS07430	COG0167	dihydroorotate dehydrogenase activity
PACID_RS07435	COG0284	orotidine-5'-phosphate decarboxylase activity
PACID_RS07440	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PACID_RS07470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PACID_RS07480	COG1058	Belongs to the CinA family
PACID_RS07480	COG1546	Belongs to the CinA family
PACID_RS07490	COG1349	DNA-binding transcription factor activity
PACID_RS07505	COG2137	regulation of response to DNA damage stimulus
PACID_RS07510	COG1418	mRNA catabolic process
PACID_RS07515	COG2017	converts alpha-aldose to the beta-anomer
PACID_RS07520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PACID_RS07765	COG3328	transposase activity
PACID_RS07845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PACID_RS07850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PACID_RS07855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PACID_RS07870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PACID_RS07875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PACID_RS07880	COG0717	Belongs to the dCTP deaminase family
PACID_RS07900	COG1643	Atp-dependent helicase
PACID_RS07910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PACID_RS07925	COG0187	DNA topoisomerase II activity
PACID_RS07945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PACID_RS07960	COG1297	OPT oligopeptide transporter protein
PACID_RS07995	COG0756	dUTP diphosphatase activity
PACID_RS08015	COG0569	domain protein
PACID_RS08020	COG0531	amino acid
PACID_RS08025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PACID_RS08030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PACID_RS08035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PACID_RS08050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PACID_RS08055	COG2326	polyphosphate kinase activity
PACID_RS08115	COG1064	alcohol dehydrogenase
PACID_RS08120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PACID_RS08130	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PACID_RS08135	COG1560	Kdo2-lipid A biosynthetic process
PACID_RS08140	COG0438	transferase activity, transferring glycosyl groups
PACID_RS08170	COG1716	ATPase activity
PACID_RS08190	COG1295	ribonuclease BN
PACID_RS08195	COG0205	6-phosphofructokinase activity
PACID_RS08205	COG0009	L-threonylcarbamoyladenylate synthase
PACID_RS08225	COG1739	Uncharacterized protein family UPF0029
PACID_RS08240	COG0443	Heat shock 70 kDa protein
PACID_RS08275	COG0531	amino acid
PACID_RS08295	COG1966	Carbon starvation protein
PACID_RS08305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PACID_RS08310	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PACID_RS08325	COG1216	Glycosyl transferase, family 2
PACID_RS08330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PACID_RS08335	COG1522	sequence-specific DNA binding
PACID_RS08340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PACID_RS08340	COG2813	Specifically methylates the guanine in position
PACID_RS08345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
PACID_RS08350	COG0427	acetyl-CoA hydrolase
PACID_RS08380	COG2801	Transposase and inactivated derivatives
PACID_RS08405	COG3550	peptidyl-serine autophosphorylation
PACID_RS08480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PACID_RS08500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PACID_RS08510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PACID_RS08540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PACID_RS08550	COG3328	transposase activity
PACID_RS08570	COG1764	response to oxidative stress
PACID_RS08580	COG1160	GTP binding
PACID_RS08585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PACID_RS08595	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PACID_RS08600	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PACID_RS08615	COG0646	methionine synthase
PACID_RS08615	COG1410	methionine synthase
PACID_RS08625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PACID_RS08635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PACID_RS08665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PACID_RS08670	COG1201	RNA secondary structure unwinding
PACID_RS08675	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PACID_RS08685	COG1758	RNA polymerase activity
PACID_RS08690	COG0194	GDP metabolic process
PACID_RS08700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PACID_RS08705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PACID_RS08715	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PACID_RS08720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PACID_RS08725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PACID_RS08730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PACID_RS08735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PACID_RS08740	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PACID_RS08745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PACID_RS08780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PACID_RS08795	COG1309	transcriptional regulator
PACID_RS08805	COG0124	histidyl-tRNA synthetase
PACID_RS08810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PACID_RS08815	COG1196	nuclear chromosome segregation
PACID_RS08820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PACID_RS08825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PACID_RS08835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PACID_RS08840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PACID_RS08845	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PACID_RS08855	COG2255	four-way junction helicase activity
PACID_RS08860	COG0632	four-way junction helicase activity
PACID_RS08865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PACID_RS08870	COG0217	transcriptional regulatory protein
PACID_RS08875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PACID_RS08880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PACID_RS08885	COG0131	Imidazoleglycerol-phosphate dehydratase
PACID_RS08890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PACID_RS08895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PACID_RS08930	COG0395	ABC-type sugar transport system, permease component
PACID_RS08950	COG0069	glutamate synthase activity
PACID_RS08950	COG0067	glutamate synthase
PACID_RS08950	COG0070	glutamate synthase
PACID_RS08955	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PACID_RS08960	COG0159	tryptophan synthase activity
PACID_RS08970	COG0134	indole-3-glycerol-phosphate synthase activity
PACID_RS08985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PACID_RS08990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PACID_RS09000	COG0735	belongs to the Fur family
PACID_RS09010	COG0423	glycine-tRNA ligase activity
PACID_RS09020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PACID_RS09025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PACID_RS09035	COG0076	glutamate decarboxylase activity
PACID_RS09045	COG1053	succinate dehydrogenase
PACID_RS09085	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PACID_RS09090	COG0358	DNA primase activity
PACID_RS09095	COG1191	sigma factor activity
PACID_RS09110	COG0488	(ABC) transporter
PACID_RS09115	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
PACID_RS09135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PACID_RS09145	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
PACID_RS09155	COG0583	DNA-binding transcription factor activity
PACID_RS09175	COG0477	Major facilitator Superfamily
PACID_RS09190	COG4974	Belongs to the 'phage' integrase family
PACID_RS09205	COG1192	Involved in chromosome partitioning
PACID_RS09255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PACID_RS09325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PACID_RS09330	COG0154	amidase activity
PACID_RS09335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PACID_RS09350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PACID_RS09360	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
PACID_RS09375	COG0482	sulfurtransferase activity
PACID_RS09400	COG0366	Alpha amylase catalytic
PACID_RS09405	COG3281	Trehalose synthase
PACID_RS09410	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PACID_RS09425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PACID_RS09435	COG0033	Phosphoglucomutase
PACID_RS09485	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PACID_RS09490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PACID_RS09495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PACID_RS09500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PACID_RS09505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PACID_RS09510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PACID_RS09515	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PACID_RS09520	COG0356	it plays a direct role in the translocation of protons across the membrane
PACID_RS09535	COG1045	serine acetyltransferase
PACID_RS09545	COG0367	asparagine synthase
PACID_RS09550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PACID_RS09560	COG0318	PFAM AMP-dependent synthetase and ligase
PACID_RS09645	COG2890	protein-(glutamine-N5) methyltransferase activity
PACID_RS09650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PACID_RS09655	COG0254	rRNA binding
PACID_RS09665	COG0083	homoserine kinase activity
PACID_RS09670	COG0460	homoserine dehydrogenase
PACID_RS09675	COG0019	diaminopimelate decarboxylase activity
PACID_RS09685	COG1611	Belongs to the LOG family
PACID_RS09695	COG0508	dehydrogenase complex catalyzes the overall conversion of
PACID_RS09695	COG0567	Dehydrogenase, E1 component
PACID_RS09720	COG1595	DNA-templated transcription, initiation
PACID_RS09730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PACID_RS09735	COG1162	GTPase activity
PACID_RS09745	COG0483	inositol monophosphate 1-phosphatase activity
PACID_RS09750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PACID_RS09765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PACID_RS09775	COG0747	negative chemotaxis
PACID_RS09795	COG1472	Belongs to the glycosyl hydrolase 3 family
PACID_RS09805	COG1615	UPF0182 protein
PACID_RS09815	COG3480	Lon protease (S16) C-terminal proteolytic domain
PACID_RS09840	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PACID_RS09845	COG1074	ATP-dependent DNA helicase activity
PACID_RS09850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PACID_RS09865	COG1278	Cold shock
PACID_RS09890	COG0180	Tryptophanyl-tRNA synthetase
PACID_RS09900	COG0613	PHP domain protein
PACID_RS09920	COG0653	protein targeting
PACID_RS09930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PACID_RS09945	COG5002	protein histidine kinase activity
PACID_RS09950	COG0745	RESPONSE REGULATOR receiver
PACID_RS09955	COG1678	Uncharacterized ACR, COG1678
PACID_RS09970	COG0165	Argininosuccinate lyase
PACID_RS09975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PACID_RS09980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PACID_RS09985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PACID_RS09995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PACID_RS10000	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PACID_RS10005	COG2177	Part of the ABC transporter FtsEX involved in
PACID_RS10010	COG2884	Cell division ATP-binding protein ftsE
PACID_RS10015	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PACID_RS10040	COG1674	ftsk spoiiie
PACID_RS10055	COG1181	Belongs to the D-alanine--D-alanine ligase family
PACID_RS10065	COG0066	3-isopropylmalate dehydratase activity
PACID_RS10070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PACID_RS10075	COG1414	Transcriptional regulator
PACID_RS10095	COG0179	Fumarylacetoacetate (FAA) hydrolase
PACID_RS10105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PACID_RS10110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PACID_RS10115	COG0473	3-isopropylmalate dehydrogenase activity
PACID_RS10135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PACID_RS10140	COG0440	acetolactate synthase activity
PACID_RS10150	COG0537	adenosine 5'-monophosphoramidase activity
PACID_RS10155	COG0107	imidazoleglycerol-phosphate synthase activity
PACID_RS10175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PACID_RS10195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PACID_RS10230	COG0504	CTP synthase activity
PACID_RS10235	COG0497	DNA recombination
PACID_RS10240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PACID_RS10255	COG1122	ATPase activity
PACID_RS10260	COG1268	BioY protein
PACID_RS10265	COG0647	UMP catabolic process
PACID_RS10300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PACID_RS10305	COG0140	phosphoribosyl-ATP diphosphatase activity
PACID_RS10310	COG3201	nicotinamide mononucleotide transporter
PACID_RS10320	COG0667	Aldo Keto reductase
PACID_RS10330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PACID_RS10335	COG2801	Transposase and inactivated derivatives
PACID_RS10360	COG1609	Transcriptional regulator
PACID_RS10365	COG2160	L-arabinose isomerase activity
PACID_RS10395	COG0395	ABC-type sugar transport system, permease component
PACID_RS10405	COG1609	Transcriptional regulator
PACID_RS10410	COG0395	ABC-type sugar transport system, permease component
PACID_RS10415	COG1175	transmembrane transport
PACID_RS10445	COG0792	nuclease activity
PACID_RS10455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PACID_RS10460	COG0681	Belongs to the peptidase S26 family
PACID_RS10465	COG0335	large ribosomal subunit rRNA binding
PACID_RS10470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PACID_RS10475	COG1053	succinate dehydrogenase
PACID_RS10485	COG0336	Belongs to the RNA methyltransferase TrmD family
PACID_RS10490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PACID_RS10495	COG1837	Belongs to the UPF0109 family
PACID_RS10500	COG0228	four-way junction DNA binding
PACID_RS10575	COG0656	L-ascorbic acid biosynthetic process
PACID_RS10580	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PACID_RS10585	COG0571	ribonuclease III activity
PACID_RS10590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PACID_RS10600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PACID_RS10605	COG0742	ribosomal rna small subunit methyltransferase
PACID_RS10625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PACID_RS10630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PACID_RS10640	COG0028	Belongs to the TPP enzyme family
PACID_RS10650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PACID_RS10655	COG1185	polyribonucleotide nucleotidyltransferase activity
PACID_RS10660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PACID_RS10680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PACID_RS10700	COG3732	PTS system glucitol sorbitol-specific
PACID_RS10715	COG0371	Dehydrogenase
PACID_RS10720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PACID_RS10730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PACID_RS10745	COG0779	Required for maturation of 30S ribosomal subunits
PACID_RS10765	COG0442	prolyl-tRNA aminoacylation
PACID_RS10775	COG1305	Transglutaminase-like
PACID_RS10805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PACID_RS10810	COG0750	zinc metalloprotease
PACID_RS10820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PACID_RS10825	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PACID_RS10830	COG0575	Belongs to the CDS family
PACID_RS10835	COG0233	cytoplasmic translational termination
PACID_RS10840	COG0528	UMP kinase activity
PACID_RS10845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PACID_RS10850	COG0052	Belongs to the universal ribosomal protein uS2 family
PACID_RS10855	COG2801	Transposase and inactivated derivatives
PACID_RS10865	COG0714	Associated with various cellular activities
PACID_RS10870	COG2425	protein containing a von Willebrand factor type A (vWA) domain
PACID_RS10875	COG3552	Protein containing von Willebrand factor type A (VWA) domain
PACID_RS10895	COG4974	Belongs to the 'phage' integrase family
PACID_RS10905	COG0242	peptide deformylase activity
PACID_RS10945	COG1119	ATPase activity
PACID_RS10950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PACID_RS10975	COG1028	Short-chain dehydrogenase reductase Sdr
PACID_RS11005	COG0488	(ABC) transporter
PACID_RS11055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PACID_RS11060	COG0396	ATPase activity
PACID_RS11085	COG2801	Transposase and inactivated derivatives
PACID_RS11095	COG1175	transmembrane transport
PACID_RS11100	COG3833	ABC-type maltose transport systems, permease component
PACID_RS11110	COG3328	transposase activity
PACID_RS11115	COG1609	Transcriptional regulator
PACID_RS11120	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
PACID_RS11125	COG1131	(ABC) transporter
PACID_RS11135	COG1612	heme a metabolic process
PACID_RS11140	COG0109	protoheme IX farnesyltransferase activity
PACID_RS11155	COG0363	glucosamine-6-phosphate deaminase activity
PACID_RS11165	COG0525	valine-tRNA ligase activity
PACID_RS11180	COG0793	Belongs to the peptidase S41A family
PACID_RS11180	COG4946	Tricorn protease homolog
PACID_RS11190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PACID_RS11195	COG0740	serine-type endopeptidase activity
PACID_RS11200	COG0740	serine-type endopeptidase activity
PACID_RS11210	COG0544	peptidyl-prolyl cis-trans isomerase activity
PACID_RS11265	COG3328	transposase activity
PACID_RS11305	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PACID_RS11305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PACID_RS11325	COG0698	ribose 5-phosphate isomerase
PACID_RS11340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PACID_RS11345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PACID_RS11360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PACID_RS11370	COG2814	Major facilitator Superfamily
PACID_RS11385	COG1022	Amp-dependent synthetase and ligase
PACID_RS11400	COG0277	FAD linked oxidase domain protein
PACID_RS11400	COG0247	lactate metabolic process
PACID_RS11435	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PACID_RS11455	COG0519	Catalyzes the synthesis of GMP from XMP
PACID_RS11460	COG1794	racemase activity, acting on amino acids and derivatives
PACID_RS11480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PACID_RS11520	COG1794	racemase activity, acting on amino acids and derivatives
PACID_RS11525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PACID_RS11530	COG0384	phenazine biosynthesis protein PhzF
PACID_RS11535	COG2226	methyltransferase
PACID_RS11550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PACID_RS11555	COG2197	response regulator
PACID_RS11560	COG4585	Histidine kinase
PACID_RS11570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PACID_RS11580	COG1113	amino acid transport
PACID_RS11595	COG1131	(ABC) transporter
PACID_RS11615	COG2855	membrane
PACID_RS11620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PACID_RS11625	COG0531	amino acid
PACID_RS11635	COG0587	DNA-directed DNA polymerase activity
PACID_RS11655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PACID_RS11675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PACID_RS11700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PACID_RS11710	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PACID_RS11715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PACID_RS11720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PACID_RS11725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PACID_RS11735	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PACID_RS11735	COG1918	ferrous iron import across plasma membrane
PACID_RS11750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PACID_RS11780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PACID_RS11830	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
PACID_RS11830	COG0662	Cupin 2, conserved barrel domain protein
PACID_RS11845	COG1316	TRANSCRIPTIONal
PACID_RS11865	COG3340	Belongs to the peptidase S51 family
PACID_RS11875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PACID_RS11885	COG0424	maF-like protein
PACID_RS11895	COG4221	oxidoreductase activity
PACID_RS11905	COG0351	phosphomethylpyrimidine kinase
PACID_RS11915	COG4770	biotin carboxylase activity
PACID_RS11935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PACID_RS11950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PACID_RS11955	COG4656	Part of a membrane complex involved in electron transport
PACID_RS11960	COG0252	asparaginase activity
PACID_RS11960	COG5275	peptidyl-tyrosine sulfation
PACID_RS11970	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
PACID_RS11990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PACID_RS11995	COG0328	RNA-DNA hybrid ribonuclease activity
PACID_RS12005	COG1079	Belongs to the binding-protein-dependent transport system permease family
PACID_RS12010	COG4603	Belongs to the binding-protein-dependent transport system permease family
PACID_RS12015	COG3845	ABC transporter
PACID_RS12030	COG1253	flavin adenine dinucleotide binding
PACID_RS12050	COG0039	L-malate dehydrogenase activity
PACID_RS12065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PACID_RS12075	COG0138	bifunctional purine biosynthesis protein purh
PACID_RS12085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PACID_RS12090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PACID_RS12090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PACID_RS12120	COG0045	succinate-CoA ligase (ADP-forming) activity
PACID_RS12140	COG1464	Belongs to the NlpA lipoprotein family
PACID_RS12145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PACID_RS12150	COG2011	ABC-type metal ion transport system permease component
PACID_RS12160	COG2261	transglycosylase associated protein
PACID_RS12165	COG2197	response regulator
PACID_RS12190	COG0519	Catalyzes the synthesis of GMP from XMP
PACID_RS12190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PACID_RS12195	COG1045	serine acetyltransferase
PACID_RS12200	COG0287	Prephenate dehydrogenase
PACID_RS12200	COG1605	Chorismate mutase
PACID_RS12220	COG0459	protein refolding
PACID_RS12225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PACID_RS12245	COG1355	regulation of microtubule-based process
PACID_RS12265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PACID_RS12275	COG1214	PFAM Peptidase M22, glycoprotease
PACID_RS12275	COG0456	acetyltransferase
PACID_RS12285	COG0513	Belongs to the DEAD box helicase family
PACID_RS12300	COG0736	holo-[acyl-carrier-protein] synthase activity
PACID_RS12305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PACID_RS12315	COG1072	(Pantothenic acid kinase))
PACID_RS12325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PACID_RS12335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PACID_RS12340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PACID_RS12360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PACID_RS12365	COG0101	tRNA pseudouridine synthase activity
PACID_RS12380	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PACID_RS12385	COG3845	ABC transporter
PACID_RS12400	COG0519	Catalyzes the synthesis of GMP from XMP
PACID_RS12400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PACID_RS12410	COG0438	transferase activity, transferring glycosyl groups
PACID_RS12415	COG0203	ribosomal protein L17
PACID_RS12420	COG0202	RNA polymerase activity
PACID_RS12425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PACID_RS12430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PACID_RS12435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PACID_RS12440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PACID_RS12445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PACID_RS12465	COG0563	adenylate kinase activity
PACID_RS12500	COG0200	Binds to the 23S rRNA
PACID_RS12505	COG1841	ribosomal large subunit assembly
PACID_RS12510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PACID_RS12515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PACID_RS12520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PACID_RS12525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PACID_RS12530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PACID_RS12535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PACID_RS12540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PACID_RS12545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PACID_RS12550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PACID_RS12555	COG0395	ABC-type sugar transport system, permease component
PACID_RS12560	COG1175	transmembrane transport
PACID_RS12580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PACID_RS12585	COG0255	Belongs to the universal ribosomal protein uL29 family
PACID_RS12590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PACID_RS12595	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PACID_RS12600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PACID_RS12605	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PACID_RS12610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PACID_RS12615	COG0089	rRNA binding
PACID_RS12620	COG0088	Forms part of the polypeptide exit tunnel
PACID_RS12625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PACID_RS12630	COG0051	transcription antitermination factor activity, RNA binding
PACID_RS12635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PACID_RS12640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PACID_RS12655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PACID_RS12660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PACID_RS12665	COG0049	tRNA binding
PACID_RS12670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PACID_RS12675	COG0673	inositol 2-dehydrogenase activity
PACID_RS12690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PACID_RS12695	COG0085	RNA polymerase activity
PACID_RS12700	COG0222	ribosome binding
PACID_RS12710	COG0081	regulation of translation
PACID_RS12715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PACID_RS12720	COG0250	Participates in transcription elongation, termination and antitermination
PACID_RS12735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PACID_RS12740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PACID_RS12750	COG2030	dehydratase
PACID_RS12755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PACID_RS12795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PACID_RS12800	COG0649	NAD binding
PACID_RS12800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PACID_RS12805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PACID_RS12810	COG0674	pyruvate-flavodoxin oxidoreductase activity
PACID_RS12810	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PACID_RS12815	COG1013	pyruvate-flavodoxin oxidoreductase activity
PACID_RS12820	COG3590	peptidase
PACID_RS12870	COG0142	geranyltranstransferase activity
PACID_RS12875	COG1007	ATP synthesis coupled electron transport
PACID_RS12890	COG0713	ATP synthesis coupled electron transport
PACID_RS12900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PACID_RS12905	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PACID_RS12910	COG1034	ATP synthesis coupled electron transport
PACID_RS12915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
PACID_RS12925	COG0649	NAD binding
PACID_RS12930	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PACID_RS12935	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PACID_RS12945	COG0644	oxidoreductase
PACID_RS12970	COG1131	(ABC) transporter
PACID_RS12975	COG2226	methyltransferase
PACID_RS12985	COG1132	(ABC) transporter
PACID_RS13005	COG2376	Dihydroxyacetone kinase
PACID_RS13010	COG1461	Dihydroxyacetone kinase
PACID_RS13015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PACID_RS13015	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
PACID_RS13015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PACID_RS13030	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PACID_RS13035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PACID_RS13055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PACID_RS13090	COG3328	transposase activity
PACID_RS13115	COG0574	Belongs to the PEP-utilizing enzyme family
PACID_RS13115	COG3848	Pyruvate phosphate dikinase
PACID_RS13130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PACID_RS13250	COG0395	ABC-type sugar transport system, permease component
PACID_RS13255	COG1175	transmembrane transport
PACID_RS13275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PACID_RS13315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PACID_RS13330	COG0252	asparaginase activity
PACID_RS13335	COG1113	amino acid transport
PACID_RS13345	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PACID_RS13350	COG0047	phosphoribosylformylglycinamidine synthase activity
PACID_RS13355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PACID_RS13365	COG3634	alkyl hydroperoxide reductase activity
PACID_RS13375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PACID_RS13380	COG0151	Belongs to the GarS family
PACID_RS13385	COG4423	Transcription factor
PACID_RS13390	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
PACID_RS13395	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PACID_RS13410	COG1937	Protein conserved in bacteria
PACID_RS13415	COG0446	pyridine nucleotide-disulphide oxidoreductase
PACID_RS13430	COG2337	Toxic component of a toxin-antitoxin (TA) module
PACID_RS13435	COG1217	gtp-binding protein TYPA
PACID_RS13445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PACID_RS13455	COG3485	protocatechuate 3,4-dioxygenase
PACID_RS13465	COG1490	D-aminoacyl-tRNA deacylase activity
PACID_RS13495	COG0745	RESPONSE REGULATOR receiver
PACID_RS13500	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PACID_RS13505	COG0406	alpha-ribazole phosphatase activity
PACID_RS13505	COG0494	nUDIX hydrolase
PACID_RS13525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PACID_RS13530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PACID_RS13535	COG3328	transposase activity
PACID_RS13545	COG0254	rRNA binding
PACID_RS13550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PACID_RS13560	COG0523	cobalamin synthesis protein
PACID_RS13575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PACID_RS13580	COG1121	(ABC) transporter
PACID_RS13590	COG0803	Belongs to the bacterial solute-binding protein 9 family
PACID_RS13595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PACID_RS13600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PACID_RS13605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PACID_RS13610	COG1120	ATPase activity
PACID_RS13630	COG0129	dihydroxy-acid dehydratase activity
PACID_RS13635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PACID_RS13645	COG2409	Drug exporters of the RND superfamily
PACID_RS13650	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PACID_RS13670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PACID_RS13680	COG0785	Cytochrome C biogenesis protein
PACID_RS13685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PACID_RS13690	COG0406	alpha-ribazole phosphatase activity
PACID_RS13700	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
PACID_RS13710	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PACID_RS13730	COG0506	proline dehydrogenase activity
PACID_RS13735	COG1082	Xylose isomerase domain protein TIM barrel
PACID_RS13745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PACID_RS13750	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PACID_RS13755	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PACID_RS13765	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PACID_RS13765	COG3253	May function as heme-dependent peroxidase
PACID_RS13770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PACID_RS13775	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PACID_RS13785	COG0181	hydroxymethylbilane synthase activity
PACID_RS13795	COG0113	porphobilinogen synthase activity
PACID_RS13800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PACID_RS13805	COG1194	a g-specific adenine glycosylase
PACID_RS13815	COG3842	ATPase activity
PACID_RS13825	COG4143	(ABC) transporter
PACID_RS13830	COG0572	uridine kinase
PACID_RS13835	COG0705	Rhomboid family
PACID_RS13900	COG0649	NAD binding
PACID_RS13915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PACID_RS13920	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PACID_RS13925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PACID_RS13930	COG0302	gtp cyclohydrolase
PACID_RS13945	COG0037	tRNA processing
PACID_RS13955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PACID_RS13965	COG3458	cephalosporin-C deacetylase activity
PACID_RS13970	COG2062	phosphohistidine phosphatase, SixA
PACID_RS14015	COG1522	sequence-specific DNA binding
PACID_RS14020	COG1619	proteins homologs of microcin C7 resistance protein MccF
PACID_RS14030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PACID_RS14035	COG0601	transmembrane transport
PACID_RS14065	COG0431	NADPH-dependent FMN reductase
PACID_RS14070	COG1231	oxidoreductase activity
PACID_RS14110	COG1774	PSP1 C-terminal conserved region
PACID_RS14120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PACID_RS14125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PACID_RS14135	COG1754	DNA topoisomerase type I activity
PACID_RS14135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PACID_RS14145	COG2890	protein-(glutamine-N5) methyltransferase activity
PACID_RS14150	COG1205	dead DEAH box helicase
PACID_RS14150	COG1111	helicase
PACID_RS14165	COG2026	Addiction module toxin, RelE StbE family
PACID_RS14235	COG0494	nUDIX hydrolase
PACID_RS14265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PACID_RS14270	COG1408	metallophosphoesterase
PACID_RS14290	COG0833	amino acid
PACID_RS14295	COG2040	homocysteine
PACID_RS14300	COG1846	Transcriptional regulator
PACID_RS14330	COG0601	transmembrane transport
PACID_RS14335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PACID_RS14340	COG0444	Belongs to the ABC transporter superfamily
PACID_RS14345	COG4608	Belongs to the ABC transporter superfamily
PACID_RS14360	COG3022	response to hydroperoxide
PACID_RS14370	COG0657	acetylesterase activity
PACID_RS14375	COG1069	ribulokinase activity
PACID_RS14380	COG1072	(Pantothenic acid kinase))
PACID_RS14395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PACID_RS14405	COG0534	Mate efflux family protein
PACID_RS14445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PACID_RS14445	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PACID_RS14455	COG2197	response regulator
PACID_RS14460	COG0753	catalase activity
PACID_RS14480	COG3285	dna ligase
PACID_RS14480	COG1793	dna ligase
PACID_RS14485	COG2124	cytochrome p450
PACID_RS14490	COG1028	Short-chain dehydrogenase reductase Sdr
PACID_RS14500	COG0783	Belongs to the Dps family
PACID_RS14505	COG1028	Short-chain dehydrogenase reductase Sdr
PACID_RS14520	COG1295	ribonuclease BN
PACID_RS14540	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PACID_RS14560	COG4572	Cation transport regulator
PACID_RS14565	COG0667	Aldo Keto reductase
PACID_RS14580	COG3158	transport of potassium into the cell
PACID_RS14620	COG1857	crispr-associated protein
PACID_RS14625	COG1518	maintenance of DNA repeat elements
PACID_RS14630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PACID_RS14635	COG3328	transposase activity
PACID_RS14655	COG0477	Major facilitator Superfamily
PACID_RS14660	COG0445	tRNA wobble uridine modification
PACID_RS14665	COG1414	Transcriptional regulator
PACID_RS14670	COG0586	Pfam SNARE associated Golgi protein
PACID_RS14680	COG0438	transferase activity, transferring glycosyl groups
PACID_RS14690	COG0745	RESPONSE REGULATOR receiver
PACID_RS14695	COG1968	undecaprenyl-diphosphatase activity
PACID_RS14705	COG0390	transport system, permease component
PACID_RS14715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PACID_RS14725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PACID_RS14730	COG3328	transposase activity
PACID_RS14735	COG4221	oxidoreductase activity
PACID_RS14760	COG1653	transport
PACID_RS14765	COG1175	transmembrane transport
PACID_RS14770	COG0395	ABC-type sugar transport system, permease component
PACID_RS14780	COG1609	Transcriptional regulator
PACID_RS14785	COG1069	ribulokinase activity
PACID_RS14790	COG1064	alcohol dehydrogenase
PACID_RS14800	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PACID_RS14805	COG1063	alcohol dehydrogenase
PACID_RS14815	COG1946	Acyl-CoA thioesterase
PACID_RS14825	COG0673	inositol 2-dehydrogenase activity
PACID_RS14830	COG1942	4-Oxalocrotonate Tautomerase
PACID_RS14870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PACID_RS14890	COG0433	COG0433 Predicted ATPase
PACID_RS14905	COG3263	regulation of cellular component size
PACID_RS14910	COG1125	glycine betaine transport
PACID_RS14910	COG0517	IMP dehydrogenase activity
PACID_RS14920	COG1174	glycine betaine transport
PACID_RS14930	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PACID_RS14950	COG3321	synthase
PACID_RS14950	COG1028	Short-chain dehydrogenase reductase Sdr
PACID_RS14950	COG0604	alcohol dehydrogenase
PACID_RS14980	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PACID_RS15005	COG2130	NADP-dependent
PACID_RS15010	COG0823	Involved in the tonB-independent uptake of proteins
PACID_RS15010	COG1506	peptidase
PACID_RS15010	COG4946	Tricorn protease homolog
PACID_RS15015	COG0584	glycerophosphoryl diester phosphodiesterase
PACID_RS15040	COG1316	TRANSCRIPTIONal
PACID_RS15045	COG1609	Transcriptional regulator
PACID_RS15050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PACID_RS15075	COG2801	Transposase and inactivated derivatives
PACID_RS15080	COG1028	Short-chain dehydrogenase reductase Sdr
PACID_RS15080	COG0604	alcohol dehydrogenase
PACID_RS15080	COG3321	synthase
PACID_RS15085	COG0137	argininosuccinate synthase activity
PACID_RS15105	COG0561	phosphatase activity
PACID_RS15115	COG2801	Transposase and inactivated derivatives
PACID_RS15130	COG0395	ABC-type sugar transport system, permease component
PACID_RS15145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PACID_RS15165	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PACID_RS15175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PACID_RS15185	COG0508	dehydrogenase complex catalyzes the overall conversion of
PACID_RS15190	COG0022	dehydrogenase e1 component
PACID_RS15205	COG0535	radical SAM domain protein
PACID_RS15235	COG0477	Major facilitator Superfamily
PACID_RS15245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PACID_RS15250	COG0006	proline dipeptidase activity
PACID_RS15260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PACID_RS15290	COG0154	amidase activity
PACID_RS15295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PACID_RS15310	COG1126	abc transporter atp-binding protein
PACID_RS15315	COG0765	amino acid transport
PACID_RS15320	COG0765	amino acid transport
PACID_RS15365	COG1715	Restriction endonuclease
PACID_RS15395	COG5002	protein histidine kinase activity
PACID_RS15410	COG1621	beta-fructofuranosidase activity
PACID_RS15415	COG2390	Transcriptional regulator
PACID_RS15435	COG0235	Class ii aldolase
PACID_RS15440	COG0656	L-ascorbic acid biosynthetic process
PACID_RS15450	COG1063	alcohol dehydrogenase
PACID_RS15460	COG0477	Major facilitator Superfamily
PACID_RS15515	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
PACID_RS15525	COG0366	Alpha amylase catalytic
PACID_RS15555	COG0366	Alpha amylase catalytic
PACID_RS15570	COG0395	ABC-type sugar transport system, permease component
PACID_RS15575	COG1175	transmembrane transport
PACID_RS15580	COG1285	pathogenesis
PACID_RS15600	COG1940	carbohydrate kinase activity
PACID_RS15610	COG1175	transmembrane transport
PACID_RS15615	COG0395	ABC-type sugar transport system, permease component
PACID_RS15620	COG0366	Alpha amylase catalytic
PACID_RS15635	COG1132	(ABC) transporter
PACID_RS15640	COG1132	(ABC) transporter
PACID_RS15655	COG2423	ornithine cyclodeaminase activity
PACID_RS15675	COG0395	ABC-type sugar transport system, permease component
PACID_RS15680	COG1175	transmembrane transport
PACID_RS15690	COG1609	Transcriptional regulator
PACID_RS15705	COG2205	protein histidine kinase activity
PACID_RS15715	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
PACID_RS15740	COG1902	pentaerythritol trinitrate reductase activity
PACID_RS15745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PACID_RS15755	COG1968	undecaprenyl-diphosphatase activity
PACID_RS15770	COG0359	binds to the 23S rRNA
PACID_RS15775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PACID_RS15785	COG0360	Binds together with S18 to 16S ribosomal RNA
PACID_RS15790	COG2837	iron assimilation
PACID_RS15795	COG2822	iron ion transport
PACID_RS15800	COG0672	)-iron permease
PACID_RS15810	COG1022	Amp-dependent synthetase and ligase
PACID_RS15825	COG0300	oxidoreductase activity
PACID_RS15870	COG0277	FAD linked oxidase domain protein
PACID_RS15880	COG2197	response regulator
PACID_RS15885	COG1051	belongs to the nudix hydrolase family
PACID_RS15890	COG1131	(ABC) transporter
PACID_RS15920	COG1136	(ABC) transporter
PACID_RS15920	COG0577	efflux transmembrane transporter activity
PACID_RS15925	COG4585	Histidine kinase
PACID_RS15930	COG0247	lactate metabolic process
PACID_RS15935	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
PACID_RS15940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PACID_RS15945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PACID_RS15960	COG1113	amino acid transport
PACID_RS15995	COG0534	Mate efflux family protein
PACID_RS16010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PACID_RS16020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PACID_RS16030	COG1175	transmembrane transport
PACID_RS16040	COG1609	Transcriptional regulator
PACID_RS16055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PACID_RS16085	COG2337	Toxic component of a toxin-antitoxin (TA) module
PACID_RS16090	COG3609	addiction module antidote protein, CC2985 family
PACID_RS16095	COG2002	toxin-antitoxin pair type II binding
PACID_RS16110	COG2146	nitrite reductase [NAD(P)H] activity
PACID_RS16120	COG1716	ATPase activity
PACID_RS16120	COG1131	(ABC) transporter
PACID_RS16120	COG0842	Transport permease protein
PACID_RS16135	COG0205	6-phosphofructokinase activity
PACID_RS16140	COG0686	Belongs to the AlaDH PNT family
PACID_RS16145	COG2267	carboxylic ester hydrolase activity
PACID_RS16190	COG1376	ErfK ybiS ycfS ynhG family protein
PACID_RS16195	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PACID_RS16205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PACID_RS16250	COG0038	chloride channel
PACID_RS16260	COG2848	UPF0210 protein
PACID_RS16265	COG3830	Belongs to the UPF0237 family
PACID_RS16275	COG0114	fumarate hydratase activity
PACID_RS16280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PACID_RS16315	COG2814	Major facilitator Superfamily
PACID_RS16325	COG1349	DNA-binding transcription factor activity
PACID_RS16330	COG0540	Belongs to the ATCase OTCase family
PACID_RS16345	COG0668	transmembrane transport
PACID_RS16355	COG1929	Belongs to the glycerate kinase type-1 family
PACID_RS16365	COG0617	tRNA 3'-terminal CCA addition
PACID_RS16370	COG1012	belongs to the aldehyde dehydrogenase family
PACID_RS16375	COG0385	Bile acid
PACID_RS16415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PACID_RS16420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PACID_RS16425	COG2390	Transcriptional regulator
PACID_RS16435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PACID_RS16450	COG0395	ABC-type sugar transport system, permease component
PACID_RS16460	COG1653	transport
PACID_RS16470	COG1609	Transcriptional regulator
PACID_RS16480	COG1733	regulation of RNA biosynthetic process
PACID_RS16490	COG0564	pseudouridine synthase activity
PACID_RS16510	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
PACID_RS16510	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
PACID_RS16515	COG4585	Histidine kinase
PACID_RS16525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PACID_RS16535	COG1082	Xylose isomerase domain protein TIM barrel
PACID_RS16540	COG0673	inositol 2-dehydrogenase activity
PACID_RS16545	COG1609	Transcriptional regulator
PACID_RS16555	COG2855	membrane
PACID_RS16560	COG1082	Xylose isomerase domain protein TIM barrel
PACID_RS16575	COG0673	inositol 2-dehydrogenase activity
PACID_RS16585	COG1609	Transcriptional regulator
PACID_RS16590	COG2814	Major facilitator Superfamily
PACID_RS16600	COG1082	Xylose isomerase domain protein TIM barrel
PACID_RS16605	COG0673	inositol 2-dehydrogenase activity
PACID_RS16610	COG1082	Xylose isomerase domain protein TIM barrel
PACID_RS16630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PACID_RS16635	COG1181	Belongs to the D-alanine--D-alanine ligase family
PACID_RS16665	COG3328	transposase activity
PACID_RS16670	COG0357	Ribosomal RNA small subunit methyltransferase G
PACID_RS16685	COG0706	membrane insertase activity
PACID_RS16690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PACID_RS16695	COG0594	ribonuclease P activity
PACID_RS16720	COG0456	acetyltransferase
PACID_RS16740	COG0464	growth
PACID_RS16830	COG1309	transcriptional regulator
PACID_RS16890	COG2801	Transposase and inactivated derivatives
PACID_RS16895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PACID_RS16905	COG2226	methyltransferase
PACID_RS16965	COG3942	CHAP domain
PACID_RS16965	COG1388	LysM domain
PACID_RS17015	COG0726	polysaccharide deacetylase
PACID_RS17025	COG1472	Belongs to the glycosyl hydrolase 3 family
PACID_RS17075	COG0515	serine threonine protein kinase
PACID_RS17080	COG1309	transcriptional regulator
PACID_RS17085	COG2233	PERMEase
PACID_RS17090	COG2233	PERMEase
PACID_RS17120	COG3152	Membrane
PACID_RS17150	COG3831	ATPase activity
PACID_RS17165	COG0629	single-stranded DNA binding
PACID_RS17265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PACID_RS17295	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PACID_RS17345	COG0515	serine threonine protein kinase
PACID_RS17360	COG2815	serine threonine protein kinase
PACID_RS17360	COG0515	serine threonine protein kinase
PACID_RS17410	COG2815	serine threonine protein kinase
PACID_RS17410	COG0515	serine threonine protein kinase
PACID_RS17435	COG0802	atpase or kinase