locus-tag	class	description
ASQ49_RS00070	COG1196	nuclear chromosome segregation
ASQ49_RS00070	COG0741	lytic transglycosylase activity
ASQ49_RS00070	COG0739	heme binding
ASQ49_RS00170	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ASQ49_RS00185	COG1970	mechanosensitive ion channel activity
ASQ49_RS00205	COG0673	inositol 2-dehydrogenase activity
ASQ49_RS00210	COG2814	Major facilitator Superfamily
ASQ49_RS00215	COG0673	inositol 2-dehydrogenase activity
ASQ49_RS00230	COG3962	Belongs to the TPP enzyme family
ASQ49_RS00235	COG3718	enzyme involved in inositol metabolism
ASQ49_RS00245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASQ49_RS00250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ASQ49_RS00255	COG3118	belongs to the thioredoxin family
ASQ49_RS00260	COG2226	methyltransferase
ASQ49_RS00265	COG1321	iron dependent repressor
ASQ49_RS00290	COG2252	PERMEase
ASQ49_RS00305	COG1278	Cold shock
ASQ49_RS00310	COG0363	glucosamine-6-phosphate deaminase activity
ASQ49_RS00365	COG1482	cell wall glycoprotein biosynthetic process
ASQ49_RS00370	COG1854	S-ribosylhomocysteine lyase activity
ASQ49_RS00400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ASQ49_RS00410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASQ49_RS00410	COG1648	precorrin-2 dehydrogenase activity
ASQ49_RS00415	COG1797	cobyrinic acid a,c-diamide synthase activity
ASQ49_RS00420	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
ASQ49_RS00445	COG0310	cobalt ion transport
ASQ49_RS00460	COG1648	precorrin-2 dehydrogenase activity
ASQ49_RS00460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ASQ49_RS00480	COG1492	cobalamin metabolic process
ASQ49_RS00495	COG4585	Histidine kinase
ASQ49_RS00515	COG0406	alpha-ribazole phosphatase activity
ASQ49_RS00525	COG2197	response regulator
ASQ49_RS00530	COG4585	Histidine kinase
ASQ49_RS00540	COG1131	(ABC) transporter
ASQ49_RS00545	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ASQ49_RS00555	COG0156	8-amino-7-oxononanoate synthase activity
ASQ49_RS00560	COG1063	alcohol dehydrogenase
ASQ49_RS00565	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS00570	COG1175	transmembrane transport
ASQ49_RS00575	COG1653	transport
ASQ49_RS00580	COG1940	carbohydrate kinase activity
ASQ49_RS00585	COG1760	l-serine dehydratase
ASQ49_RS00595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASQ49_RS00610	COG3842	ATPase activity
ASQ49_RS00665	COG0626	cystathionine gamma-synthase activity
ASQ49_RS00680	COG0215	cysteine-tRNA ligase activity
ASQ49_RS00685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASQ49_RS00695	COG2814	Major facilitator Superfamily
ASQ49_RS00700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ASQ49_RS00720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ASQ49_RS00725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ASQ49_RS00740	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ASQ49_RS00750	COG3775	system Galactitol-specific IIC component
ASQ49_RS00760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASQ49_RS00765	COG1329	Transcriptional regulator
ASQ49_RS00780	COG5002	protein histidine kinase activity
ASQ49_RS00785	COG0704	Plays a role in the regulation of phosphate uptake
ASQ49_RS00790	COG0588	phosphoglycerate mutase activity
ASQ49_RS00795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASQ49_RS00800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASQ49_RS00830	COG0191	fructose-bisphosphate aldolase activity
ASQ49_RS00845	COG0586	Pfam SNARE associated Golgi protein
ASQ49_RS00865	COG0489	protein tyrosine kinase activity
ASQ49_RS00870	COG2244	polysaccharide biosynthetic process
ASQ49_RS00880	COG0438	transferase activity, transferring glycosyl groups
ASQ49_RS00890	COG0438	transferase activity, transferring glycosyl groups
ASQ49_RS00910	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ASQ49_RS00910	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ASQ49_RS00915	COG1704	LemA family
ASQ49_RS00935	COG0436	Aminotransferase
ASQ49_RS00940	COG1012	belongs to the aldehyde dehydrogenase family
ASQ49_RS00950	COG1174	glycine betaine transport
ASQ49_RS00960	COG1174	glycine betaine transport
ASQ49_RS00975	COG1131	(ABC) transporter
ASQ49_RS00980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_RS00995	COG4176	ABC-type proline glycine betaine transport system permease component
ASQ49_RS01000	COG0517	IMP dehydrogenase activity
ASQ49_RS01000	COG4175	Glycine betaine
ASQ49_RS01005	COG3012	SEC-C Motif Domain Protein
ASQ49_RS01025	COG3328	transposase activity
ASQ49_RS01045	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ASQ49_RS01055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ASQ49_RS01065	COG0702	epimerase
ASQ49_RS01080	COG1511	domain protein
ASQ49_RS01095	COG1486	melibiose metabolic process
ASQ49_RS01105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASQ49_RS01115	COG1175	transmembrane transport
ASQ49_RS01120	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS01125	COG0542	response to heat
ASQ49_RS01135	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS01150	COG3588	fructose-bisphosphate aldolase
ASQ49_RS01175	COG4585	Histidine kinase
ASQ49_RS01180	COG2197	response regulator
ASQ49_RS01190	COG0577	efflux transmembrane transporter activity
ASQ49_RS01190	COG1136	(ABC) transporter
ASQ49_RS01195	COG0577	efflux transmembrane transporter activity
ASQ49_RS01195	COG1136	(ABC) transporter
ASQ49_RS01205	COG1113	amino acid transport
ASQ49_RS01210	COG0569	domain protein
ASQ49_RS01210	COG2985	domain, Protein
ASQ49_RS01215	COG3527	Alpha-acetolactate decarboxylase
ASQ49_RS01220	COG1063	alcohol dehydrogenase
ASQ49_RS01225	COG0789	Transcriptional regulator
ASQ49_RS01230	COG0484	heat shock protein binding
ASQ49_RS01235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ASQ49_RS01255	COG0745	RESPONSE REGULATOR receiver
ASQ49_RS01260	COG2205	protein histidine kinase activity
ASQ49_RS01265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ASQ49_RS01280	COG0574	Belongs to the PEP-utilizing enzyme family
ASQ49_RS01280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASQ49_RS01285	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ASQ49_RS01290	COG2813	Specifically methylates the guanine in position
ASQ49_RS01295	COG3830	Belongs to the UPF0237 family
ASQ49_RS01295	COG0560	Phosphoserine phosphatase
ASQ49_RS01315	COG1309	transcriptional regulator
ASQ49_RS01320	COG1131	(ABC) transporter
ASQ49_RS01335	COG2814	Major facilitator Superfamily
ASQ49_RS01340	COG4608	Belongs to the ABC transporter superfamily
ASQ49_RS01345	COG0154	amidase activity
ASQ49_RS01355	COG1309	transcriptional regulator
ASQ49_RS01360	COG0477	Major facilitator Superfamily
ASQ49_RS01400	COG1027	Aspartate ammonia-lyase
ASQ49_RS01415	COG0601	transmembrane transport
ASQ49_RS01425	COG1609	Transcriptional regulator
ASQ49_RS01465	COG1609	Transcriptional regulator
ASQ49_RS01470	COG3254	rhamnose metabolic process
ASQ49_RS01480	COG4952	isomerase
ASQ49_RS01485	COG1070	Carbohydrate kinase
ASQ49_RS01495	COG1012	belongs to the aldehyde dehydrogenase family
ASQ49_RS01510	COG2814	Major facilitator Superfamily
ASQ49_RS01530	COG0018	arginyl-trna synthetase
ASQ49_RS01535	COG0656	L-ascorbic acid biosynthetic process
ASQ49_RS01540	COG2814	Major facilitator Superfamily
ASQ49_RS01555	COG0166	Belongs to the GPI family
ASQ49_RS01565	COG4581	dead DEAH box helicase
ASQ49_RS01575	COG1881	PFAM PEBP family protein
ASQ49_RS01595	COG0667	Aldo Keto reductase
ASQ49_RS01605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASQ49_RS01610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ASQ49_RS01630	COG0583	DNA-binding transcription factor activity
ASQ49_RS01635	COG2814	Major facilitator Superfamily
ASQ49_RS01650	COG2801	Transposase and inactivated derivatives
ASQ49_RS01680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ASQ49_RS01685	COG0561	phosphatase activity
ASQ49_RS01690	COG0561	phosphatase activity
ASQ49_RS01715	COG1136	(ABC) transporter
ASQ49_RS01715	COG0577	efflux transmembrane transporter activity
ASQ49_RS01740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ASQ49_RS01745	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ASQ49_RS01795	COG1131	(ABC) transporter
ASQ49_RS01800	COG1309	transcriptional regulator
ASQ49_RS01805	COG1113	amino acid transport
ASQ49_RS01815	COG3328	transposase activity
ASQ49_RS01820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASQ49_RS01825	COG1695	Transcriptional regulator
ASQ49_RS01830	COG0477	Major facilitator Superfamily
ASQ49_RS01895	COG0438	transferase activity, transferring glycosyl groups
ASQ49_RS01910	COG0489	protein tyrosine kinase activity
ASQ49_RS01920	COG1316	TRANSCRIPTIONal
ASQ49_RS01940	COG0604	alcohol dehydrogenase
ASQ49_RS01945	COG3408	Glycogen debranching enzyme
ASQ49_RS01955	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ASQ49_RS01960	COG1088	dTDP-glucose 4,6-dehydratase activity
ASQ49_RS01970	COG1716	ATPase activity
ASQ49_RS01975	COG1716	ATPase activity
ASQ49_RS01990	COG0768	penicillin binding
ASQ49_RS01995	COG0515	serine threonine protein kinase
ASQ49_RS02015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASQ49_RS02020	COG0393	Putative heavy-metal-binding
ASQ49_RS02030	COG1953	Uracil, thiamine, allantoin
ASQ49_RS02035	COG1301	dicarboxylic acid transport
ASQ49_RS02040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASQ49_RS02045	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ASQ49_RS02065	COG2186	Transcriptional regulator
ASQ49_RS02070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ASQ49_RS02075	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ASQ49_RS02100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASQ49_RS02105	COG1309	transcriptional regulator
ASQ49_RS02120	COG1609	Transcriptional regulator
ASQ49_RS02130	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS02145	COG1454	alcohol dehydrogenase
ASQ49_RS02150	COG0477	Major facilitator Superfamily
ASQ49_RS02175	COG2197	response regulator
ASQ49_RS02185	COG1271	oxidase subunit
ASQ49_RS02190	COG1294	oxidase, subunit
ASQ49_RS02195	COG4988	ABC transporter
ASQ49_RS02200	COG1132	(ABC) transporter
ASQ49_RS02205	COG1556	Lactate utilization protein
ASQ49_RS02210	COG1139	Iron-sulfur cluster binding protein
ASQ49_RS02215	COG0247	lactate metabolic process
ASQ49_RS02220	COG1620	l-lactate permease
ASQ49_RS02225	COG2186	Transcriptional regulator
ASQ49_RS02240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ASQ49_RS02240	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASQ49_RS02240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASQ49_RS02240	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASQ49_RS02245	COG0167	dihydroorotate dehydrogenase activity
ASQ49_RS02255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASQ49_RS02270	COG1937	Protein conserved in bacteria
ASQ49_RS02275	COG0305	Participates in initiation and elongation during chromosome replication
ASQ49_RS02280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASQ49_RS02280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASQ49_RS02285	COG3118	belongs to the thioredoxin family
ASQ49_RS02290	COG0492	ferredoxin-NADP+ reductase activity
ASQ49_RS02295	COG0386	Belongs to the glutathione peroxidase family
ASQ49_RS02300	COG1846	Transcriptional regulator
ASQ49_RS02320	COG2094	Belongs to the DNA glycosylase MPG family
ASQ49_RS02335	COG1643	Atp-dependent helicase
ASQ49_RS02350	COG2897	thiosulfate sulfurtransferase activity
ASQ49_RS02395	COG0463	Glycosyl transferase, family 2
ASQ49_RS02410	COG0438	transferase activity, transferring glycosyl groups
ASQ49_RS02425	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ASQ49_RS02430	COG1126	abc transporter atp-binding protein
ASQ49_RS02435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASQ49_RS02440	COG0765	amino acid transport
ASQ49_RS02445	COG0765	amino acid transport
ASQ49_RS02455	COG1105	Belongs to the carbohydrate kinase PfkB family
ASQ49_RS02460	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ASQ49_RS02460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASQ49_RS02460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ASQ49_RS02490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASQ49_RS02530	COG0438	transferase activity, transferring glycosyl groups
ASQ49_RS02550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASQ49_RS02615	COG2801	Transposase and inactivated derivatives
ASQ49_RS02730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ASQ49_RS02750	COG3620	sequence-specific DNA binding
ASQ49_RS02815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ASQ49_RS02840	COG2072	flavoprotein involved in K transport
ASQ49_RS02875	COG1253	flavin adenine dinucleotide binding
ASQ49_RS02910	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASQ49_RS02925	COG1063	alcohol dehydrogenase
ASQ49_RS02930	COG0586	Pfam SNARE associated Golgi protein
ASQ49_RS02940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASQ49_RS02950	COG1119	ATPase activity
ASQ49_RS02965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ASQ49_RS02970	COG1414	Transcriptional regulator
ASQ49_RS02975	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ASQ49_RS02980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASQ49_RS02985	COG0402	S-adenosylhomocysteine deaminase activity
ASQ49_RS02990	COG1228	amidohydrolase
ASQ49_RS03010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ASQ49_RS03015	COG1609	Transcriptional regulator
ASQ49_RS03020	COG0673	inositol 2-dehydrogenase activity
ASQ49_RS03030	COG2186	Transcriptional regulator
ASQ49_RS03040	COG5564	TIM-barrel signal transduction protein
ASQ49_RS03070	COG2211	Major facilitator Superfamily
ASQ49_RS03115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ASQ49_RS03130	COG3328	transposase activity
ASQ49_RS03155	COG2826	transposase and inactivated derivatives, IS30 family
ASQ49_RS03160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ASQ49_RS03165	COG2801	Transposase and inactivated derivatives
ASQ49_RS03195	COG1904	glucuronate isomerase
ASQ49_RS03200	COG2721	sulfolactate sulfo-lyase activity
ASQ49_RS03210	COG1609	Transcriptional regulator
ASQ49_RS03215	COG1414	Transcriptional regulator
ASQ49_RS03220	COG0800	Aldolase
ASQ49_RS03225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASQ49_RS03230	COG1482	cell wall glycoprotein biosynthetic process
ASQ49_RS03240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASQ49_RS03260	COG3119	arylsulfatase activity
ASQ49_RS03265	COG1940	carbohydrate kinase activity
ASQ49_RS03270	COG0477	Major facilitator Superfamily
ASQ49_RS03275	COG3119	arylsulfatase activity
ASQ49_RS03280	COG2149	membrane
ASQ49_RS03290	COG0641	radical SAM
ASQ49_RS03305	COG1070	Carbohydrate kinase
ASQ49_RS03320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ASQ49_RS03320	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ASQ49_RS03365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASQ49_RS03365	COG0519	Catalyzes the synthesis of GMP from XMP
ASQ49_RS03395	COG3328	transposase activity
ASQ49_RS03400	COG0210	DNA helicase
ASQ49_RS03450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ASQ49_RS03505	COG1175	transmembrane transport
ASQ49_RS03510	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS03515	COG1653	transport
ASQ49_RS03520	COG0584	glycerophosphoryl diester phosphodiesterase
ASQ49_RS03525	COG1609	Transcriptional regulator
ASQ49_RS03535	COG1285	pathogenesis
ASQ49_RS03555	COG4948	Mandelate Racemase Muconate Lactonizing
ASQ49_RS03565	COG0656	L-ascorbic acid biosynthetic process
ASQ49_RS03575	COG1312	Catalyzes the dehydration of D-mannonate
ASQ49_RS03580	COG0246	Mannitol dehydrogenase
ASQ49_RS03585	COG1904	glucuronate isomerase
ASQ49_RS03590	COG1609	Transcriptional regulator
ASQ49_RS03600	COG1012	belongs to the aldehyde dehydrogenase family
ASQ49_RS03625	COG3942	CHAP domain
ASQ49_RS03630	COG1609	Transcriptional regulator
ASQ49_RS03640	COG1129	ABC transporter
ASQ49_RS03645	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASQ49_RS03650	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASQ49_RS03655	COG3250	beta-galactosidase activity
ASQ49_RS03665	COG3386	PFAM SMP-30 Gluconolaconase
ASQ49_RS03670	COG0352	thiamine-phosphate diphosphorylase activity
ASQ49_RS03675	COG0351	phosphomethylpyrimidine kinase
ASQ49_RS03675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ASQ49_RS03675	COG0352	thiamine-phosphate diphosphorylase activity
ASQ49_RS03685	COG0315	cyclic pyranopterin monophosphate synthase activity
ASQ49_RS03685	COG0521	Mo-molybdopterin cofactor biosynthetic process
ASQ49_RS03690	COG0315	cyclic pyranopterin monophosphate synthase activity
ASQ49_RS03700	COG0314	molybdopterin synthase activity
ASQ49_RS03710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ASQ49_RS03730	COG1140	nitrate reductase beta subunit
ASQ49_RS03750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ASQ49_RS03755	COG0633	Ferredoxin
ASQ49_RS03755	COG0543	2 iron, 2 sulfur cluster binding
ASQ49_RS03760	COG1151	hydroxylamine reductase activity
ASQ49_RS03770	COG2337	Toxic component of a toxin-antitoxin (TA) module
ASQ49_RS03800	COG0601	transmembrane transport
ASQ49_RS03805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASQ49_RS03815	COG4166	transmembrane transport
ASQ49_RS03820	COG0435	Glutathione S-transferase
ASQ49_RS03835	COG0456	acetyltransferase
ASQ49_RS03870	COG0783	Belongs to the Dps family
ASQ49_RS03875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ASQ49_RS03885	COG2217	Heavy metal translocating P-type atpase
ASQ49_RS03895	COG3189	MarR family transcriptional regulator
ASQ49_RS03935	COG0205	6-phosphofructokinase activity
ASQ49_RS03960	COG0577	efflux transmembrane transporter activity
ASQ49_RS03960	COG1136	(ABC) transporter
ASQ49_RS03970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASQ49_RS03980	COG0511	ligase activity, forming carbon-carbon bonds
ASQ49_RS03980	COG5016	pyruvate
ASQ49_RS03990	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASQ49_RS04000	COG1254	Belongs to the acylphosphatase family
ASQ49_RS04020	COG0281	malic enzyme
ASQ49_RS04035	COG1321	iron dependent repressor
ASQ49_RS04035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASQ49_RS04040	COG1914	H( )-stimulated, divalent metal cation uptake system
ASQ49_RS04045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASQ49_RS04050	COG0477	Major facilitator Superfamily
ASQ49_RS04060	COG2814	Major facilitator Superfamily
ASQ49_RS04070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASQ49_RS04075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASQ49_RS04085	COG0438	transferase activity, transferring glycosyl groups
ASQ49_RS04095	COG2801	Transposase and inactivated derivatives
ASQ49_RS04105	COG2409	Drug exporters of the RND superfamily
ASQ49_RS04110	COG1309	transcriptional regulator
ASQ49_RS04130	COG2022	thiamine diphosphate biosynthetic process
ASQ49_RS04140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ASQ49_RS04140	COG0596	Alpha beta hydrolase
ASQ49_RS04145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASQ49_RS04180	COG0656	L-ascorbic acid biosynthetic process
ASQ49_RS04190	COG1473	amidohydrolase
ASQ49_RS04205	COG0730	response to heat
ASQ49_RS04220	COG0175	sulfate reduction
ASQ49_RS04250	COG2132	Multicopper oxidase
ASQ49_RS04260	COG0745	RESPONSE REGULATOR receiver
ASQ49_RS04265	COG5002	protein histidine kinase activity
ASQ49_RS04275	COG4585	Histidine kinase
ASQ49_RS04280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ASQ49_RS04285	COG2205	protein histidine kinase activity
ASQ49_RS04295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ASQ49_RS04325	COG1132	(ABC) transporter
ASQ49_RS04330	COG0477	Major facilitator Superfamily
ASQ49_RS04335	COG1690	Belongs to the RtcB family
ASQ49_RS04340	COG3657	addiction module killer protein
ASQ49_RS04345	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ASQ49_RS04355	COG2197	response regulator
ASQ49_RS04360	COG1136	(ABC) transporter
ASQ49_RS04385	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ASQ49_RS04415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASQ49_RS04425	COG1012	belongs to the aldehyde dehydrogenase family
ASQ49_RS04495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ASQ49_RS04515	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ASQ49_RS04520	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS04525	COG1175	transmembrane transport
ASQ49_RS04530	COG1653	transport
ASQ49_RS04540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASQ49_RS04545	COG1126	abc transporter atp-binding protein
ASQ49_RS04550	COG0765	amino acid transport
ASQ49_RS04560	COG0095	Lipoate-protein ligase
ASQ49_RS04570	COG1131	(ABC) transporter
ASQ49_RS04590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ASQ49_RS04595	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ASQ49_RS04605	COG3775	system Galactitol-specific IIC component
ASQ49_RS04610	COG3414	Phosphotransferase system galactitol-specific IIB component
ASQ49_RS04615	COG1063	alcohol dehydrogenase
ASQ49_RS04635	COG0726	polysaccharide deacetylase
ASQ49_RS04655	COG4139	cobalamin transport
ASQ49_RS04660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ASQ49_RS04675	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
ASQ49_RS04695	COG3328	transposase activity
ASQ49_RS04755	COG0714	Associated with various cellular activities
ASQ49_RS04765	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
ASQ49_RS04825	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ASQ49_RS04850	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ASQ49_RS04855	COG0039	L-malate dehydrogenase activity
ASQ49_RS04860	COG0281	malic enzyme
ASQ49_RS04875	COG0039	L-malate dehydrogenase activity
ASQ49_RS04940	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
ASQ49_RS04945	COG1396	sequence-specific DNA binding
ASQ49_RS04985	COG1869	D-ribose catabolic process
ASQ49_RS04990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASQ49_RS05000	COG1172	Belongs to the binding-protein-dependent transport system permease family
ASQ49_RS05005	COG1129	ABC transporter
ASQ49_RS05010	COG1609	Transcriptional regulator
ASQ49_RS05020	COG3266	domain, Protein
ASQ49_RS05025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASQ49_RS05030	COG0187	DNA topoisomerase II activity
ASQ49_RS05040	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
ASQ49_RS05045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ASQ49_RS05055	COG0592	DNA-directed DNA polymerase activity
ASQ49_RS05060	COG0577	efflux transmembrane transporter activity
ASQ49_RS05060	COG1136	(ABC) transporter
ASQ49_RS05065	COG0577	efflux transmembrane transporter activity
ASQ49_RS05065	COG1136	(ABC) transporter
ASQ49_RS05070	COG3328	transposase activity
ASQ49_RS05085	COG0706	membrane insertase activity
ASQ49_RS05090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ASQ49_RS05095	COG0594	ribonuclease P activity
ASQ49_RS05100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ASQ49_RS05105	COG3328	transposase activity
ASQ49_RS05110	COG0357	Ribosomal RNA small subunit methyltransferase G
ASQ49_RS05115	COG3328	transposase activity
ASQ49_RS05135	COG1793	dna ligase
ASQ49_RS05135	COG3285	dna ligase
ASQ49_RS05150	COG1181	Belongs to the D-alanine--D-alanine ligase family
ASQ49_RS05155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_RS05175	COG1082	Xylose isomerase domain protein TIM barrel
ASQ49_RS05180	COG0673	inositol 2-dehydrogenase activity
ASQ49_RS05185	COG1082	Xylose isomerase domain protein TIM barrel
ASQ49_RS05195	COG2814	Major facilitator Superfamily
ASQ49_RS05200	COG1609	Transcriptional regulator
ASQ49_RS05205	COG2814	Major facilitator Superfamily
ASQ49_RS05210	COG0673	inositol 2-dehydrogenase activity
ASQ49_RS05220	COG0673	inositol 2-dehydrogenase activity
ASQ49_RS05230	COG2855	membrane
ASQ49_RS05240	COG1609	Transcriptional regulator
ASQ49_RS05250	COG1082	Xylose isomerase domain protein TIM barrel
ASQ49_RS05260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ASQ49_RS05275	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ASQ49_RS05275	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ASQ49_RS05295	COG0564	pseudouridine synthase activity
ASQ49_RS05305	COG1733	regulation of RNA biosynthetic process
ASQ49_RS05315	COG1609	Transcriptional regulator
ASQ49_RS05325	COG1653	transport
ASQ49_RS05335	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS05350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ASQ49_RS05360	COG2390	Transcriptional regulator
ASQ49_RS05365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ASQ49_RS05370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ASQ49_RS05385	COG2815	serine threonine protein kinase
ASQ49_RS05385	COG0515	serine threonine protein kinase
ASQ49_RS05405	COG0385	Bile acid
ASQ49_RS05410	COG1012	belongs to the aldehyde dehydrogenase family
ASQ49_RS05415	COG0617	tRNA 3'-terminal CCA addition
ASQ49_RS05425	COG1929	Belongs to the glycerate kinase type-1 family
ASQ49_RS05435	COG0668	transmembrane transport
ASQ49_RS05450	COG0540	Belongs to the ATCase OTCase family
ASQ49_RS05455	COG1349	DNA-binding transcription factor activity
ASQ49_RS05480	COG1131	(ABC) transporter
ASQ49_RS05505	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ASQ49_RS05510	COG0114	fumarate hydratase activity
ASQ49_RS05520	COG3830	Belongs to the UPF0237 family
ASQ49_RS05525	COG2848	UPF0210 protein
ASQ49_RS05535	COG0038	chloride channel
ASQ49_RS05575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ASQ49_RS05585	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASQ49_RS05590	COG1376	ErfK ybiS ycfS ynhG family protein
ASQ49_RS05630	COG2267	carboxylic ester hydrolase activity
ASQ49_RS05635	COG0686	Belongs to the AlaDH PNT family
ASQ49_RS05640	COG0205	6-phosphofructokinase activity
ASQ49_RS05650	COG0515	serine threonine protein kinase
ASQ49_RS05655	COG0842	Transport permease protein
ASQ49_RS05655	COG1131	(ABC) transporter
ASQ49_RS05655	COG1716	ATPase activity
ASQ49_RS05665	COG2146	nitrite reductase [NAD(P)H] activity
ASQ49_RS05680	COG3609	addiction module antidote protein, CC2985 family
ASQ49_RS05685	COG2337	Toxic component of a toxin-antitoxin (TA) module
ASQ49_RS05715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ASQ49_RS05730	COG1609	Transcriptional regulator
ASQ49_RS05740	COG1175	transmembrane transport
ASQ49_RS05750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ASQ49_RS05760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ASQ49_RS05775	COG0534	Mate efflux family protein
ASQ49_RS05840	COG1113	amino acid transport
ASQ49_RS05855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASQ49_RS05860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ASQ49_RS05865	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
ASQ49_RS05870	COG0247	lactate metabolic process
ASQ49_RS05875	COG4585	Histidine kinase
ASQ49_RS05885	COG0577	efflux transmembrane transporter activity
ASQ49_RS05885	COG1136	(ABC) transporter
ASQ49_RS05910	COG1131	(ABC) transporter
ASQ49_RS05915	COG1051	belongs to the nudix hydrolase family
ASQ49_RS05920	COG2197	response regulator
ASQ49_RS05930	COG0277	FAD linked oxidase domain protein
ASQ49_RS05975	COG0300	oxidoreductase activity
ASQ49_RS05990	COG1022	Amp-dependent synthetase and ligase
ASQ49_RS06000	COG0672	)-iron permease
ASQ49_RS06005	COG2822	iron ion transport
ASQ49_RS06010	COG2837	iron assimilation
ASQ49_RS06015	COG0360	Binds together with S18 to 16S ribosomal RNA
ASQ49_RS06025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ASQ49_RS06030	COG0359	binds to the 23S rRNA
ASQ49_RS06045	COG1968	undecaprenyl-diphosphatase activity
ASQ49_RS06055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ASQ49_RS06060	COG1902	pentaerythritol trinitrate reductase activity
ASQ49_RS06085	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ASQ49_RS06095	COG2205	protein histidine kinase activity
ASQ49_RS06110	COG1609	Transcriptional regulator
ASQ49_RS06120	COG1175	transmembrane transport
ASQ49_RS06125	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS06145	COG2423	ornithine cyclodeaminase activity
ASQ49_RS06160	COG1132	(ABC) transporter
ASQ49_RS06165	COG1132	(ABC) transporter
ASQ49_RS06180	COG0366	Alpha amylase catalytic
ASQ49_RS06185	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS06190	COG1175	transmembrane transport
ASQ49_RS06220	COG1285	pathogenesis
ASQ49_RS06225	COG1175	transmembrane transport
ASQ49_RS06230	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS06245	COG0366	Alpha amylase catalytic
ASQ49_RS06250	COG1472	Belongs to the glycosyl hydrolase 3 family
ASQ49_RS06280	COG0366	Alpha amylase catalytic
ASQ49_RS06295	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ASQ49_RS06350	COG0477	Major facilitator Superfamily
ASQ49_RS06360	COG1063	alcohol dehydrogenase
ASQ49_RS06370	COG0656	L-ascorbic acid biosynthetic process
ASQ49_RS06375	COG0235	Class ii aldolase
ASQ49_RS06395	COG2390	Transcriptional regulator
ASQ49_RS06400	COG1621	beta-fructofuranosidase activity
ASQ49_RS06415	COG5002	protein histidine kinase activity
ASQ49_RS06445	COG1715	Restriction endonuclease
ASQ49_RS06490	COG0765	amino acid transport
ASQ49_RS06495	COG0765	amino acid transport
ASQ49_RS06500	COG1126	abc transporter atp-binding protein
ASQ49_RS06515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ASQ49_RS06520	COG0154	amidase activity
ASQ49_RS06560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ASQ49_RS06570	COG0006	proline dipeptidase activity
ASQ49_RS06575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_RS06585	COG0477	Major facilitator Superfamily
ASQ49_RS06620	COG0535	radical SAM domain protein
ASQ49_RS06635	COG0022	dehydrogenase e1 component
ASQ49_RS06640	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASQ49_RS06650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ASQ49_RS06660	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ASQ49_RS06680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ASQ49_RS06700	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS06720	COG0561	phosphatase activity
ASQ49_RS06740	COG0137	argininosuccinate synthase activity
ASQ49_RS06745	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_RS06745	COG0604	alcohol dehydrogenase
ASQ49_RS06745	COG3321	synthase
ASQ49_RS06770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASQ49_RS06775	COG1609	Transcriptional regulator
ASQ49_RS06780	COG1316	TRANSCRIPTIONal
ASQ49_RS06805	COG0584	glycerophosphoryl diester phosphodiesterase
ASQ49_RS06810	COG0823	Involved in the tonB-independent uptake of proteins
ASQ49_RS06810	COG4946	Tricorn protease homolog
ASQ49_RS06810	COG1506	peptidase
ASQ49_RS06815	COG2130	NADP-dependent
ASQ49_RS06840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ASQ49_RS06870	COG0604	alcohol dehydrogenase
ASQ49_RS06870	COG3321	synthase
ASQ49_RS06870	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_RS06895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ASQ49_RS06905	COG1174	glycine betaine transport
ASQ49_RS06915	COG1125	glycine betaine transport
ASQ49_RS06915	COG0517	IMP dehydrogenase activity
ASQ49_RS06920	COG3263	regulation of cellular component size
ASQ49_RS06935	COG0433	COG0433 Predicted ATPase
ASQ49_RS06955	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ASQ49_RS06965	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ASQ49_RS06985	COG1942	4-Oxalocrotonate Tautomerase
ASQ49_RS06990	COG0673	inositol 2-dehydrogenase activity
ASQ49_RS07000	COG1946	Acyl-CoA thioesterase
ASQ49_RS07010	COG1063	alcohol dehydrogenase
ASQ49_RS07015	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ASQ49_RS07025	COG1064	alcohol dehydrogenase
ASQ49_RS07030	COG1069	ribulokinase activity
ASQ49_RS07035	COG1609	Transcriptional regulator
ASQ49_RS07045	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS07050	COG1175	transmembrane transport
ASQ49_RS07055	COG1653	transport
ASQ49_RS07080	COG4221	oxidoreductase activity
ASQ49_RS07085	COG3328	transposase activity
ASQ49_RS07090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ASQ49_RS07100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_RS07110	COG0390	transport system, permease component
ASQ49_RS07120	COG1968	undecaprenyl-diphosphatase activity
ASQ49_RS07125	COG0745	RESPONSE REGULATOR receiver
ASQ49_RS07135	COG0438	transferase activity, transferring glycosyl groups
ASQ49_RS07145	COG0586	Pfam SNARE associated Golgi protein
ASQ49_RS07150	COG1414	Transcriptional regulator
ASQ49_RS07155	COG0445	tRNA wobble uridine modification
ASQ49_RS07160	COG0477	Major facilitator Superfamily
ASQ49_RS07170	COG3328	transposase activity
ASQ49_RS07195	COG3158	transport of potassium into the cell
ASQ49_RS07215	COG0667	Aldo Keto reductase
ASQ49_RS07220	COG4572	Cation transport regulator
ASQ49_RS07240	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ASQ49_RS07260	COG1295	ribonuclease BN
ASQ49_RS07270	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_RS07275	COG0783	Belongs to the Dps family
ASQ49_RS07285	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_RS07290	COG2124	cytochrome p450
ASQ49_RS07295	COG3285	dna ligase
ASQ49_RS07295	COG1793	dna ligase
ASQ49_RS07315	COG0753	catalase activity
ASQ49_RS07320	COG2197	response regulator
ASQ49_RS07330	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
ASQ49_RS07330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ASQ49_RS07375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASQ49_RS07380	COG0534	Mate efflux family protein
ASQ49_RS07390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ASQ49_RS07405	COG1072	(Pantothenic acid kinase))
ASQ49_RS07410	COG1069	ribulokinase activity
ASQ49_RS07415	COG0657	acetylesterase activity
ASQ49_RS07425	COG3022	response to hydroperoxide
ASQ49_RS07440	COG4608	Belongs to the ABC transporter superfamily
ASQ49_RS07445	COG0444	Belongs to the ABC transporter superfamily
ASQ49_RS07450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASQ49_RS07455	COG0601	transmembrane transport
ASQ49_RS07485	COG1846	Transcriptional regulator
ASQ49_RS07490	COG2040	homocysteine
ASQ49_RS07495	COG0833	amino acid
ASQ49_RS07515	COG1408	metallophosphoesterase
ASQ49_RS07520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ASQ49_RS07550	COG0494	nUDIX hydrolase
ASQ49_RS07620	COG2026	Addiction module toxin, RelE StbE family
ASQ49_RS07635	COG1205	dead DEAH box helicase
ASQ49_RS07635	COG1111	helicase
ASQ49_RS07640	COG2890	protein-(glutamine-N5) methyltransferase activity
ASQ49_RS07650	COG1754	DNA topoisomerase type I activity
ASQ49_RS07650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ASQ49_RS07660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ASQ49_RS07665	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ASQ49_RS07675	COG1774	PSP1 C-terminal conserved region
ASQ49_RS07715	COG1231	oxidoreductase activity
ASQ49_RS07720	COG0431	NADPH-dependent FMN reductase
ASQ49_RS07750	COG0601	transmembrane transport
ASQ49_RS07755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASQ49_RS07765	COG1619	proteins homologs of microcin C7 resistance protein MccF
ASQ49_RS07770	COG1522	sequence-specific DNA binding
ASQ49_RS07815	COG2062	phosphohistidine phosphatase, SixA
ASQ49_RS07820	COG3458	cephalosporin-C deacetylase activity
ASQ49_RS07830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ASQ49_RS07840	COG0037	tRNA processing
ASQ49_RS07855	COG0302	gtp cyclohydrolase
ASQ49_RS07860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ASQ49_RS07865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ASQ49_RS07870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ASQ49_RS07885	COG0649	NAD binding
ASQ49_RS07890	COG2801	Transposase and inactivated derivatives
ASQ49_RS07955	COG0457	Tetratricopeptide repeat
ASQ49_RS07955	COG0705	Rhomboid family
ASQ49_RS07960	COG0572	uridine kinase
ASQ49_RS07965	COG4143	(ABC) transporter
ASQ49_RS07975	COG3842	ATPase activity
ASQ49_RS07985	COG1194	a g-specific adenine glycosylase
ASQ49_RS07990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ASQ49_RS07995	COG0113	porphobilinogen synthase activity
ASQ49_RS08005	COG0181	hydroxymethylbilane synthase activity
ASQ49_RS08015	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ASQ49_RS08020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ASQ49_RS08025	COG3253	May function as heme-dependent peroxidase
ASQ49_RS08025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ASQ49_RS08040	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ASQ49_RS08045	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ASQ49_RS08050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ASQ49_RS08060	COG1082	Xylose isomerase domain protein TIM barrel
ASQ49_RS08065	COG0506	proline dehydrogenase activity
ASQ49_RS08080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ASQ49_RS08090	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ASQ49_RS08100	COG0406	alpha-ribazole phosphatase activity
ASQ49_RS08105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ASQ49_RS08110	COG0785	Cytochrome C biogenesis protein
ASQ49_RS08120	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ASQ49_RS08140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ASQ49_RS08145	COG2409	Drug exporters of the RND superfamily
ASQ49_RS08155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ASQ49_RS08160	COG0129	dihydroxy-acid dehydratase activity
ASQ49_RS08180	COG1120	ATPase activity
ASQ49_RS08185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASQ49_RS08190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ASQ49_RS08195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ASQ49_RS08200	COG0803	Belongs to the bacterial solute-binding protein 9 family
ASQ49_RS08210	COG1121	(ABC) transporter
ASQ49_RS08215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASQ49_RS08225	COG0523	cobalamin synthesis protein
ASQ49_RS08235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASQ49_RS08240	COG0254	rRNA binding
ASQ49_RS08255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ASQ49_RS08260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ASQ49_RS08280	COG0406	alpha-ribazole phosphatase activity
ASQ49_RS08280	COG0494	nUDIX hydrolase
ASQ49_RS08285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ASQ49_RS08290	COG0745	RESPONSE REGULATOR receiver
ASQ49_RS08320	COG1490	D-aminoacyl-tRNA deacylase activity
ASQ49_RS08325	COG3485	protocatechuate 3,4-dioxygenase
ASQ49_RS08335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ASQ49_RS08345	COG1217	gtp-binding protein TYPA
ASQ49_RS08350	COG2337	Toxic component of a toxin-antitoxin (TA) module
ASQ49_RS08365	COG0446	pyridine nucleotide-disulphide oxidoreductase
ASQ49_RS08370	COG1937	Protein conserved in bacteria
ASQ49_RS08385	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ASQ49_RS08390	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
ASQ49_RS08395	COG4423	Transcription factor
ASQ49_RS08400	COG0151	Belongs to the GarS family
ASQ49_RS08405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ASQ49_RS08415	COG3634	alkyl hydroperoxide reductase activity
ASQ49_RS08425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ASQ49_RS08430	COG0047	phosphoribosylformylglycinamidine synthase activity
ASQ49_RS08435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ASQ49_RS08445	COG1113	amino acid transport
ASQ49_RS08450	COG0252	asparaginase activity
ASQ49_RS08465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ASQ49_RS08505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ASQ49_RS08525	COG1175	transmembrane transport
ASQ49_RS08530	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS08650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASQ49_RS08665	COG0574	Belongs to the PEP-utilizing enzyme family
ASQ49_RS08665	COG3848	Pyruvate phosphate dikinase
ASQ49_RS08710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASQ49_RS08720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ASQ49_RS08740	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ASQ49_RS08745	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ASQ49_RS08760	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
ASQ49_RS08760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASQ49_RS08760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ASQ49_RS08765	COG1461	Dihydroxyacetone kinase
ASQ49_RS08770	COG2376	Dihydroxyacetone kinase
ASQ49_RS08790	COG1132	(ABC) transporter
ASQ49_RS08800	COG2226	methyltransferase
ASQ49_RS08805	COG1131	(ABC) transporter
ASQ49_RS08830	COG0644	oxidoreductase
ASQ49_RS08840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_RS08845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_RS08850	COG0649	NAD binding
ASQ49_RS08860	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ASQ49_RS08865	COG1034	ATP synthesis coupled electron transport
ASQ49_RS08870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ASQ49_RS08875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_RS08885	COG0713	ATP synthesis coupled electron transport
ASQ49_RS08900	COG1007	ATP synthesis coupled electron transport
ASQ49_RS08905	COG0142	geranyltranstransferase activity
ASQ49_RS08955	COG3590	peptidase
ASQ49_RS08960	COG1013	pyruvate-flavodoxin oxidoreductase activity
ASQ49_RS08965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ASQ49_RS08965	COG0674	pyruvate-flavodoxin oxidoreductase activity
ASQ49_RS08970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_RS08975	COG0649	NAD binding
ASQ49_RS08975	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_RS08980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ASQ49_RS09020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ASQ49_RS09025	COG2030	dehydratase
ASQ49_RS09035	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ASQ49_RS09040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_RS09055	COG0250	Participates in transcription elongation, termination and antitermination
ASQ49_RS09060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ASQ49_RS09065	COG0081	regulation of translation
ASQ49_RS09075	COG0222	ribosome binding
ASQ49_RS09080	COG0085	RNA polymerase activity
ASQ49_RS09085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ASQ49_RS09105	COG0673	inositol 2-dehydrogenase activity
ASQ49_RS09110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ASQ49_RS09115	COG0049	tRNA binding
ASQ49_RS09120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ASQ49_RS09125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ASQ49_RS09140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASQ49_RS09145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASQ49_RS09150	COG0051	transcription antitermination factor activity, RNA binding
ASQ49_RS09155	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ASQ49_RS09160	COG0088	Forms part of the polypeptide exit tunnel
ASQ49_RS09165	COG0089	rRNA binding
ASQ49_RS09170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ASQ49_RS09175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ASQ49_RS09180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ASQ49_RS09185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ASQ49_RS09190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ASQ49_RS09195	COG0255	Belongs to the universal ribosomal protein uL29 family
ASQ49_RS09200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ASQ49_RS09220	COG1175	transmembrane transport
ASQ49_RS09225	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS09230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASQ49_RS09235	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ASQ49_RS09240	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ASQ49_RS09245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ASQ49_RS09250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ASQ49_RS09255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ASQ49_RS09260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ASQ49_RS09265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ASQ49_RS09270	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ASQ49_RS09275	COG1841	ribosomal large subunit assembly
ASQ49_RS09280	COG0200	Binds to the 23S rRNA
ASQ49_RS09315	COG0563	adenylate kinase activity
ASQ49_RS09335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ASQ49_RS09340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ASQ49_RS09345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ASQ49_RS09350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ASQ49_RS09355	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ASQ49_RS09360	COG0202	RNA polymerase activity
ASQ49_RS09365	COG0203	ribosomal protein L17
ASQ49_RS09370	COG0438	transferase activity, transferring glycosyl groups
ASQ49_RS09380	COG0519	Catalyzes the synthesis of GMP from XMP
ASQ49_RS09380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASQ49_RS09395	COG3845	ABC transporter
ASQ49_RS09400	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ASQ49_RS09415	COG0101	tRNA pseudouridine synthase activity
ASQ49_RS09420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ASQ49_RS09440	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ASQ49_RS09445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ASQ49_RS09455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASQ49_RS09465	COG1072	(Pantothenic acid kinase))
ASQ49_RS09475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ASQ49_RS09480	COG0736	holo-[acyl-carrier-protein] synthase activity
ASQ49_RS09495	COG0513	Belongs to the DEAD box helicase family
ASQ49_RS09500	COG0802	atpase or kinase
ASQ49_RS09505	COG1214	PFAM Peptidase M22, glycoprotease
ASQ49_RS09505	COG0456	acetyltransferase
ASQ49_RS09515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ASQ49_RS09535	COG1355	regulation of microtubule-based process
ASQ49_RS09555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ASQ49_RS09560	COG0459	protein refolding
ASQ49_RS09580	COG1605	Chorismate mutase
ASQ49_RS09580	COG0287	Prephenate dehydrogenase
ASQ49_RS09585	COG1045	serine acetyltransferase
ASQ49_RS09590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ASQ49_RS09590	COG0519	Catalyzes the synthesis of GMP from XMP
ASQ49_RS09615	COG2197	response regulator
ASQ49_RS09620	COG2261	transglycosylase associated protein
ASQ49_RS09630	COG2011	ABC-type metal ion transport system permease component
ASQ49_RS09635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ASQ49_RS09640	COG1464	Belongs to the NlpA lipoprotein family
ASQ49_RS09650	COG2801	Transposase and inactivated derivatives
ASQ49_RS09665	COG0045	succinate-CoA ligase (ADP-forming) activity
ASQ49_RS09695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASQ49_RS09695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ASQ49_RS09700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ASQ49_RS09710	COG0138	bifunctional purine biosynthesis protein purh
ASQ49_RS09720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ASQ49_RS09735	COG0039	L-malate dehydrogenase activity
ASQ49_RS09755	COG1253	flavin adenine dinucleotide binding
ASQ49_RS09770	COG3845	ABC transporter
ASQ49_RS09775	COG4603	Belongs to the binding-protein-dependent transport system permease family
ASQ49_RS09780	COG1079	Belongs to the binding-protein-dependent transport system permease family
ASQ49_RS09790	COG0328	RNA-DNA hybrid ribonuclease activity
ASQ49_RS09795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASQ49_RS09815	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ASQ49_RS09830	COG4656	Part of a membrane complex involved in electron transport
ASQ49_RS09835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASQ49_RS09850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ASQ49_RS09870	COG4770	biotin carboxylase activity
ASQ49_RS09880	COG0351	phosphomethylpyrimidine kinase
ASQ49_RS09890	COG4221	oxidoreductase activity
ASQ49_RS09905	COG0424	maF-like protein
ASQ49_RS09915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ASQ49_RS09925	COG3340	Belongs to the peptidase S51 family
ASQ49_RS09945	COG1316	TRANSCRIPTIONal
ASQ49_RS09960	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ASQ49_RS09960	COG0662	Cupin 2, conserved barrel domain protein
ASQ49_RS10010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ASQ49_RS10050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ASQ49_RS10065	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ASQ49_RS10065	COG1918	ferrous iron import across plasma membrane
ASQ49_RS10075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ASQ49_RS10080	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ASQ49_RS10085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ASQ49_RS10090	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ASQ49_RS10095	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ASQ49_RS10100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ASQ49_RS10125	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ASQ49_RS10150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASQ49_RS10165	COG0587	DNA-directed DNA polymerase activity
ASQ49_RS10175	COG0531	amino acid
ASQ49_RS10180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASQ49_RS10185	COG2855	membrane
ASQ49_RS10205	COG1131	(ABC) transporter
ASQ49_RS10220	COG1113	amino acid transport
ASQ49_RS10230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ASQ49_RS10240	COG4585	Histidine kinase
ASQ49_RS10245	COG2197	response regulator
ASQ49_RS10250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ASQ49_RS10265	COG2226	methyltransferase
ASQ49_RS10270	COG0384	phenazine biosynthesis protein PhzF
ASQ49_RS10275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ASQ49_RS10280	COG1794	racemase activity, acting on amino acids and derivatives
ASQ49_RS10320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ASQ49_RS10340	COG1794	racemase activity, acting on amino acids and derivatives
ASQ49_RS10345	COG0519	Catalyzes the synthesis of GMP from XMP
ASQ49_RS10355	COG4106	trans-aconitate 2-methyltransferase activity
ASQ49_RS10365	COG2801	Transposase and inactivated derivatives
ASQ49_RS10370	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ASQ49_RS10385	COG0629	single-stranded DNA binding
ASQ49_RS10400	COG0277	FAD linked oxidase domain protein
ASQ49_RS10400	COG0247	lactate metabolic process
ASQ49_RS10415	COG1022	Amp-dependent synthetase and ligase
ASQ49_RS10430	COG2814	Major facilitator Superfamily
ASQ49_RS10440	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ASQ49_RS10455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ASQ49_RS10460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ASQ49_RS10475	COG0698	ribose 5-phosphate isomerase
ASQ49_RS10495	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ASQ49_RS10495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ASQ49_RS10515	COG0544	peptidyl-prolyl cis-trans isomerase activity
ASQ49_RS10525	COG0740	serine-type endopeptidase activity
ASQ49_RS10530	COG0740	serine-type endopeptidase activity
ASQ49_RS10535	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ASQ49_RS10545	COG4946	Tricorn protease homolog
ASQ49_RS10545	COG0793	Belongs to the peptidase S41A family
ASQ49_RS10560	COG0525	valine-tRNA ligase activity
ASQ49_RS10570	COG0363	glucosamine-6-phosphate deaminase activity
ASQ49_RS10585	COG0109	protoheme IX farnesyltransferase activity
ASQ49_RS10590	COG1612	heme a metabolic process
ASQ49_RS10600	COG1131	(ABC) transporter
ASQ49_RS10605	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ASQ49_RS10610	COG1609	Transcriptional regulator
ASQ49_RS10615	COG3833	ABC-type maltose transport systems, permease component
ASQ49_RS10620	COG1175	transmembrane transport
ASQ49_RS10650	COG0396	ATPase activity
ASQ49_RS10655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ASQ49_RS10705	COG0488	(ABC) transporter
ASQ49_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_RS10760	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ASQ49_RS10765	COG1119	ATPase activity
ASQ49_RS10805	COG0242	peptide deformylase activity
ASQ49_RS10815	COG4974	Belongs to the 'phage' integrase family
ASQ49_RS10830	COG3552	Protein containing von Willebrand factor type A (VWA) domain
ASQ49_RS10835	COG2425	protein containing a von Willebrand factor type A (vWA) domain
ASQ49_RS10840	COG0714	Associated with various cellular activities
ASQ49_RS10845	COG3831	ATPase activity
ASQ49_RS10855	COG0052	Belongs to the universal ribosomal protein uS2 family
ASQ49_RS10860	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ASQ49_RS10865	COG0528	UMP kinase activity
ASQ49_RS10870	COG0233	cytoplasmic translational termination
ASQ49_RS10875	COG0575	Belongs to the CDS family
ASQ49_RS10880	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ASQ49_RS10885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ASQ49_RS10895	COG0750	zinc metalloprotease
ASQ49_RS10900	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ASQ49_RS10930	COG1305	Transglutaminase-like
ASQ49_RS10940	COG0442	prolyl-tRNA aminoacylation
ASQ49_RS10960	COG0779	Required for maturation of 30S ribosomal subunits
ASQ49_RS10975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ASQ49_RS10980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ASQ49_RS10985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ASQ49_RS10990	COG0371	Dehydrogenase
ASQ49_RS11005	COG3732	PTS system glucitol sorbitol-specific
ASQ49_RS11025	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ASQ49_RS11045	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ASQ49_RS11050	COG1185	polyribonucleotide nucleotidyltransferase activity
ASQ49_RS11055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ASQ49_RS11065	COG0028	Belongs to the TPP enzyme family
ASQ49_RS11075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ASQ49_RS11080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ASQ49_RS11100	COG0742	ribosomal rna small subunit methyltransferase
ASQ49_RS11105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ASQ49_RS11115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ASQ49_RS11120	COG0571	ribonuclease III activity
ASQ49_RS11125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASQ49_RS11130	COG0656	L-ascorbic acid biosynthetic process
ASQ49_RS11205	COG0228	four-way junction DNA binding
ASQ49_RS11210	COG1837	Belongs to the UPF0109 family
ASQ49_RS11215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ASQ49_RS11220	COG0336	Belongs to the RNA methyltransferase TrmD family
ASQ49_RS11230	COG1053	succinate dehydrogenase
ASQ49_RS11235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ASQ49_RS11240	COG0335	large ribosomal subunit rRNA binding
ASQ49_RS11245	COG0681	Belongs to the peptidase S26 family
ASQ49_RS11250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ASQ49_RS11260	COG0792	nuclease activity
ASQ49_RS11295	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS11300	COG1609	Transcriptional regulator
ASQ49_RS11310	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS11340	COG2160	L-arabinose isomerase activity
ASQ49_RS11345	COG1609	Transcriptional regulator
ASQ49_RS11355	COG3415	Transposase
ASQ49_RS11355	COG2801	Transposase and inactivated derivatives
ASQ49_RS11380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ASQ49_RS11390	COG0667	Aldo Keto reductase
ASQ49_RS11400	COG3201	nicotinamide mononucleotide transporter
ASQ49_RS11405	COG0140	phosphoribosyl-ATP diphosphatase activity
ASQ49_RS11410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ASQ49_RS11445	COG0647	UMP catabolic process
ASQ49_RS11450	COG1268	BioY protein
ASQ49_RS11455	COG1122	ATPase activity
ASQ49_RS11470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ASQ49_RS11475	COG0497	DNA recombination
ASQ49_RS11480	COG0504	CTP synthase activity
ASQ49_RS11515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ASQ49_RS11535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASQ49_RS11555	COG0107	imidazoleglycerol-phosphate synthase activity
ASQ49_RS11560	COG0537	adenosine 5'-monophosphoramidase activity
ASQ49_RS11570	COG0440	acetolactate synthase activity
ASQ49_RS11575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ASQ49_RS11595	COG0473	3-isopropylmalate dehydrogenase activity
ASQ49_RS11600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ASQ49_RS11605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASQ49_RS11615	COG0179	Fumarylacetoacetate (FAA) hydrolase
ASQ49_RS11635	COG1414	Transcriptional regulator
ASQ49_RS11640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ASQ49_RS11645	COG0066	3-isopropylmalate dehydratase activity
ASQ49_RS11655	COG1181	Belongs to the D-alanine--D-alanine ligase family
ASQ49_RS11665	COG2801	Transposase and inactivated derivatives
ASQ49_RS11675	COG1674	ftsk spoiiie
ASQ49_RS11685	COG3152	Membrane
ASQ49_RS11700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ASQ49_RS11705	COG2884	Cell division ATP-binding protein ftsE
ASQ49_RS11710	COG2177	Part of the ABC transporter FtsEX involved in
ASQ49_RS11715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ASQ49_RS11720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ASQ49_RS11730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ASQ49_RS11740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ASQ49_RS11745	COG0165	Argininosuccinate lyase
ASQ49_RS11760	COG1678	Uncharacterized ACR, COG1678
ASQ49_RS11765	COG0745	RESPONSE REGULATOR receiver
ASQ49_RS11770	COG5002	protein histidine kinase activity
ASQ49_RS11775	COG5401	PFAM Sporulation and spore germination
ASQ49_RS11785	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ASQ49_RS11795	COG0653	protein targeting
ASQ49_RS11815	COG0613	PHP domain protein
ASQ49_RS11825	COG0180	Tryptophanyl-tRNA synthetase
ASQ49_RS11850	COG1278	Cold shock
ASQ49_RS11875	COG1074	ATP-dependent DNA helicase activity
ASQ49_RS11880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ASQ49_RS11905	COG3480	Lon protease (S16) C-terminal proteolytic domain
ASQ49_RS11915	COG1615	UPF0182 protein
ASQ49_RS11925	COG1472	Belongs to the glycosyl hydrolase 3 family
ASQ49_RS11945	COG0747	negative chemotaxis
ASQ49_RS11955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ASQ49_RS11970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ASQ49_RS11975	COG0483	inositol monophosphate 1-phosphatase activity
ASQ49_RS11985	COG1162	GTPase activity
ASQ49_RS11990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ASQ49_RS12000	COG1595	DNA-templated transcription, initiation
ASQ49_RS12025	COG0567	Dehydrogenase, E1 component
ASQ49_RS12025	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASQ49_RS12035	COG1611	Belongs to the LOG family
ASQ49_RS12045	COG0019	diaminopimelate decarboxylase activity
ASQ49_RS12050	COG0460	homoserine dehydrogenase
ASQ49_RS12055	COG0083	homoserine kinase activity
ASQ49_RS12065	COG0254	rRNA binding
ASQ49_RS12070	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ASQ49_RS12075	COG2890	protein-(glutamine-N5) methyltransferase activity
ASQ49_RS12155	COG0318	PFAM AMP-dependent synthetase and ligase
ASQ49_RS12165	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ASQ49_RS12170	COG0367	asparagine synthase
ASQ49_RS12180	COG1045	serine acetyltransferase
ASQ49_RS12195	COG0356	it plays a direct role in the translocation of protons across the membrane
ASQ49_RS12200	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASQ49_RS12205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ASQ49_RS12210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ASQ49_RS12215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ASQ49_RS12220	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ASQ49_RS12225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ASQ49_RS12230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ASQ49_RS12285	COG0033	Phosphoglucomutase
ASQ49_RS12295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ASQ49_RS12310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ASQ49_RS12315	COG3281	Trehalose synthase
ASQ49_RS12320	COG0366	Alpha amylase catalytic
ASQ49_RS12345	COG0482	sulfurtransferase activity
ASQ49_RS12360	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
ASQ49_RS12385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASQ49_RS12390	COG0154	amidase activity
ASQ49_RS12395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ASQ49_RS12400	COG2233	PERMEase
ASQ49_RS12405	COG2233	PERMEase
ASQ49_RS12420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ASQ49_RS12425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ASQ49_RS12440	COG0134	indole-3-glycerol-phosphate synthase activity
ASQ49_RS12450	COG0159	tryptophan synthase activity
ASQ49_RS12455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ASQ49_RS12460	COG0070	glutamate synthase
ASQ49_RS12460	COG0067	glutamate synthase
ASQ49_RS12460	COG0069	glutamate synthase activity
ASQ49_RS12480	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS12515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ASQ49_RS12520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ASQ49_RS12525	COG0131	Imidazoleglycerol-phosphate dehydratase
ASQ49_RS12530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ASQ49_RS12535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ASQ49_RS12540	COG0217	transcriptional regulatory protein
ASQ49_RS12545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ASQ49_RS12550	COG0632	four-way junction helicase activity
ASQ49_RS12555	COG2255	four-way junction helicase activity
ASQ49_RS12565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASQ49_RS12570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ASQ49_RS12575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ASQ49_RS12585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ASQ49_RS12590	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ASQ49_RS12595	COG1196	nuclear chromosome segregation
ASQ49_RS12600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ASQ49_RS12605	COG0124	histidyl-tRNA synthetase
ASQ49_RS12615	COG1309	transcriptional regulator
ASQ49_RS12630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ASQ49_RS12665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ASQ49_RS12670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ASQ49_RS12675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ASQ49_RS12680	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ASQ49_RS12685	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ASQ49_RS12690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ASQ49_RS12695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ASQ49_RS12705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ASQ49_RS12710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ASQ49_RS12720	COG0194	GDP metabolic process
ASQ49_RS12725	COG1758	RNA polymerase activity
ASQ49_RS12735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ASQ49_RS12740	COG1201	RNA secondary structure unwinding
ASQ49_RS12745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ASQ49_RS12775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ASQ49_RS12785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ASQ49_RS12795	COG0646	methionine synthase
ASQ49_RS12795	COG1410	methionine synthase
ASQ49_RS12810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASQ49_RS12815	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ASQ49_RS12825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ASQ49_RS12830	COG1160	GTP binding
ASQ49_RS12840	COG1764	response to oxidative stress
ASQ49_RS12870	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ASQ49_RS12900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ASQ49_RS12910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_RS12930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ASQ49_RS12940	COG0277	FAD linked oxidase domain protein
ASQ49_RS13000	COG3550	peptidyl-serine autophosphorylation
ASQ49_RS13030	COG2807	transmembrane transport
ASQ49_RS13055	COG0427	acetyl-CoA hydrolase
ASQ49_RS13060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ASQ49_RS13065	COG2813	Specifically methylates the guanine in position
ASQ49_RS13065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ASQ49_RS13070	COG1522	sequence-specific DNA binding
ASQ49_RS13075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ASQ49_RS13080	COG1216	Glycosyl transferase, family 2
ASQ49_RS13095	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
ASQ49_RS13100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ASQ49_RS13110	COG1966	Carbon starvation protein
ASQ49_RS13125	COG0531	amino acid
ASQ49_RS13175	COG1739	Uncharacterized protein family UPF0029
ASQ49_RS13180	COG1472	Belongs to the glycosyl hydrolase 3 family
ASQ49_RS13195	COG0009	L-threonylcarbamoyladenylate synthase
ASQ49_RS13205	COG0205	6-phosphofructokinase activity
ASQ49_RS13210	COG1295	ribonuclease BN
ASQ49_RS13230	COG1716	ATPase activity
ASQ49_RS13260	COG0438	transferase activity, transferring glycosyl groups
ASQ49_RS13265	COG1560	Kdo2-lipid A biosynthetic process
ASQ49_RS13270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ASQ49_RS13280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ASQ49_RS13285	COG1064	alcohol dehydrogenase
ASQ49_RS13315	COG0726	polysaccharide deacetylase
ASQ49_RS13345	COG2326	polyphosphate kinase activity
ASQ49_RS13350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASQ49_RS13365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ASQ49_RS13370	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ASQ49_RS13375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ASQ49_RS13380	COG0531	amino acid
ASQ49_RS13385	COG0569	domain protein
ASQ49_RS13405	COG0756	dUTP diphosphatase activity
ASQ49_RS13440	COG1297	OPT oligopeptide transporter protein
ASQ49_RS13450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ASQ49_RS13470	COG0187	DNA topoisomerase II activity
ASQ49_RS13485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ASQ49_RS13495	COG1643	Atp-dependent helicase
ASQ49_RS13515	COG0717	Belongs to the dCTP deaminase family
ASQ49_RS13520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ASQ49_RS13525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ASQ49_RS13540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ASQ49_RS13545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ASQ49_RS13550	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ASQ49_RS13560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASQ49_RS13570	COG1418	mRNA catabolic process
ASQ49_RS13575	COG2137	regulation of response to DNA damage stimulus
ASQ49_RS13590	COG1349	DNA-binding transcription factor activity
ASQ49_RS13600	COG1058	Belongs to the CinA family
ASQ49_RS13600	COG1546	Belongs to the CinA family
ASQ49_RS13610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ASQ49_RS13640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ASQ49_RS13645	COG0284	orotidine-5'-phosphate decarboxylase activity
ASQ49_RS13650	COG0167	dihydroorotate dehydrogenase activity
ASQ49_RS13655	COG0543	2 iron, 2 sulfur cluster binding
ASQ49_RS13660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ASQ49_RS13665	COG0505	Belongs to the CarA family
ASQ49_RS13670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ASQ49_RS13685	COG0667	Aldo Keto reductase
ASQ49_RS13695	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ASQ49_RS13710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ASQ49_RS13720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ASQ49_RS13725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ASQ49_RS13750	COG2304	oxidoreductase activity
ASQ49_RS13760	COG0714	Associated with various cellular activities
ASQ49_RS13790	COG0477	Major facilitator Superfamily
ASQ49_RS13795	COG1309	transcriptional regulator
ASQ49_RS13800	COG0515	serine threonine protein kinase
ASQ49_RS13810	COG0583	DNA-binding transcription factor activity
ASQ49_RS13820	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ASQ49_RS13830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ASQ49_RS13850	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ASQ49_RS13855	COG0488	(ABC) transporter
ASQ49_RS13875	COG1191	sigma factor activity
ASQ49_RS13880	COG0358	DNA primase activity
ASQ49_RS13885	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ASQ49_RS13915	COG1053	succinate dehydrogenase
ASQ49_RS13925	COG0076	glutamate decarboxylase activity
ASQ49_RS13935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ASQ49_RS13940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ASQ49_RS13950	COG0423	glycine-tRNA ligase activity
ASQ49_RS13960	COG0735	belongs to the Fur family
ASQ49_RS13985	COG4716	Myosin-crossreactive antigen
ASQ49_RS13990	COG1063	alcohol dehydrogenase
ASQ49_RS13995	COG1381	Involved in DNA repair and RecF pathway recombination
ASQ49_RS14010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASQ49_RS14020	COG0765	amino acid transport
ASQ49_RS14025	COG0765	amino acid transport
ASQ49_RS14030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASQ49_RS14035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ASQ49_RS14045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ASQ49_RS14055	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ASQ49_RS14075	COG2226	methyltransferase
ASQ49_RS14115	COG4152	abc transporter atp-binding protein
ASQ49_RS14120	COG2197	response regulator
ASQ49_RS14130	COG0343	queuine tRNA-ribosyltransferase activity
ASQ49_RS14135	COG5006	permease, DMT superfamily
ASQ49_RS14140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASQ49_RS14155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ASQ49_RS14155	COG2213	PTS system mannitol-specific
ASQ49_RS14160	COG1063	alcohol dehydrogenase
ASQ49_RS14170	COG0484	heat shock protein binding
ASQ49_RS14175	COG1420	regulation of RNA biosynthetic process
ASQ49_RS14185	COG0483	inositol monophosphate 1-phosphatase activity
ASQ49_RS14205	COG1175	transmembrane transport
ASQ49_RS14210	COG0395	ABC-type sugar transport system, permease component
ASQ49_RS14220	COG0477	Major facilitator Superfamily
ASQ49_RS14225	COG1309	transcriptional regulator
ASQ49_RS14230	COG1131	(ABC) transporter
ASQ49_RS14245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASQ49_RS14250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ASQ49_RS14260	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ASQ49_RS14270	COG1169	isochorismate synthase
ASQ49_RS14275	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ASQ49_RS14280	COG4948	Mandelate Racemase Muconate Lactonizing
ASQ49_RS14300	COG0481	GTPase activity
ASQ49_RS14310	COG0268	Binds directly to 16S ribosomal RNA
ASQ49_RS14320	COG1061	Type III restriction enzyme res subunit
ASQ49_RS14325	COG0658	competence protein
ASQ49_RS14325	COG2333	competence protein COMEC
ASQ49_RS14335	COG0495	leucyl-tRNA aminoacylation
ASQ49_RS14350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ASQ49_RS14360	COG0590	tRNA wobble adenosine to inosine editing
ASQ49_RS14435	COG0488	(ABC) transporter
ASQ49_RS14515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ASQ49_RS14520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ASQ49_RS14525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ASQ49_RS14530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ASQ49_RS14540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ASQ49_RS14545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ASQ49_RS14550	COG1530	ribonuclease E activity
ASQ49_RS14560	COG1472	Belongs to the glycosyl hydrolase 3 family
ASQ49_RS14570	COG0105	UTP biosynthetic process
ASQ49_RS14580	COG0285	dihydrofolate synthase activity
ASQ49_RS14590	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ASQ49_RS14595	COG0149	triose-phosphate isomerase activity
ASQ49_RS14600	COG0126	phosphoglycerate kinase activity
ASQ49_RS14605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASQ49_RS14610	COG1481	regulation of sporulation
ASQ49_RS14620	COG1660	Displays ATPase and GTPase activities
ASQ49_RS14625	COG0322	excinuclease ABC activity
ASQ49_RS14645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ASQ49_RS14660	COG0556	nucleotide-excision repair
ASQ49_RS14675	COG0237	dephospho-CoA kinase activity
ASQ49_RS14680	COG0539	negative regulation of cytoplasmic translation
ASQ49_RS14705	COG2050	protein possibly involved in aromatic compounds catabolism
ASQ49_RS14720	COG0469	pyruvate kinase activity
ASQ49_RS14750	COG1799	cell septum assembly
ASQ49_RS14760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ASQ49_RS14770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ASQ49_RS14775	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ASQ49_RS14780	COG0772	Belongs to the SEDS family
ASQ49_RS14785	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ASQ49_RS14790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ASQ49_RS14795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ASQ49_RS14805	COG0768	penicillin binding
ASQ49_RS14815	COG0275	rRNA processing
ASQ49_RS14820	COG2001	Belongs to the MraZ family
ASQ49_RS14825	COG0714	Associated with various cellular activities
ASQ49_RS14845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ASQ49_RS14850	COG0509	glycine decarboxylation via glycine cleavage system
ASQ49_RS14855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASQ49_RS14855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ASQ49_RS14860	COG1131	(ABC) transporter
ASQ49_RS14880	COG3265	gluconokinase activity
ASQ49_RS14890	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ASQ49_RS14900	COG0596	Alpha beta hydrolase
ASQ49_RS14905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ASQ49_RS14905	COG1116	anion transmembrane transporter activity
ASQ49_RS14925	COG0210	DNA helicase
ASQ49_RS14930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ASQ49_RS14935	COG0142	geranyltranstransferase activity
ASQ49_RS14940	COG0352	thiamine-phosphate diphosphorylase activity
ASQ49_RS14950	COG0515	serine threonine protein kinase
ASQ49_RS14950	COG2815	serine threonine protein kinase
ASQ49_RS14965	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ASQ49_RS14970	COG2197	response regulator
ASQ49_RS14990	COG1940	carbohydrate kinase activity
ASQ49_RS15035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ASQ49_RS15045	COG1845	cytochrome c oxidase, subunit III
ASQ49_RS15050	COG2010	Cytochrome c
ASQ49_RS15055	COG0723	plastoquinol--plastocyanin reductase activity
ASQ49_RS15060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ASQ49_RS15080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ASQ49_RS15085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ASQ49_RS15125	COG0508	dehydrogenase complex catalyzes the overall conversion of
ASQ49_RS15130	COG0321	lipoyl(octanoyl) transferase activity
ASQ49_RS15145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ASQ49_RS15155	COG0488	(ABC) transporter
ASQ49_RS15160	COG2239	Acts as a magnesium transporter
ASQ49_RS15165	COG0586	Pfam SNARE associated Golgi protein
ASQ49_RS15185	COG0174	glutamine synthetase
ASQ49_RS15195	COG3093	addiction module antidote protein HigA
ASQ49_RS15210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ASQ49_RS15220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ASQ49_RS15245	COG0598	Magnesium transport protein CorA
ASQ49_RS15265	COG0531	amino acid
ASQ49_RS15270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ASQ49_RS15285	COG0006	proline dipeptidase activity
ASQ49_RS15320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ASQ49_RS15325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ASQ49_RS15355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ASQ49_RS15360	COG0297	glycogen (starch) synthase activity
ASQ49_RS15370	COG1611	Belongs to the LOG family
ASQ49_RS15380	COG2171	N-acyltransferase activity
ASQ49_RS15405	COG2720	vancomycin resistance protein
ASQ49_RS15410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ASQ49_RS15415	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ASQ49_RS15420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ASQ49_RS15425	COG2814	Major facilitator Superfamily
ASQ49_RS15475	COG0647	UMP catabolic process
ASQ49_RS15485	COG0698	ribose 5-phosphate isomerase
ASQ49_RS15490	COG1349	DNA-binding transcription factor activity
ASQ49_RS15495	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
ASQ49_RS15500	COG2376	Dihydroxyacetone kinase
ASQ49_RS15505	COG1063	alcohol dehydrogenase
ASQ49_RS15510	COG1012	belongs to the aldehyde dehydrogenase family
ASQ49_RS15530	COG1121	(ABC) transporter
ASQ49_RS15535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ASQ49_RS15555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ASQ49_RS15565	COG0765	amino acid transport
ASQ49_RS15585	COG2501	S4 domain
ASQ49_RS15620	COG0833	amino acid
ASQ49_RS15635	COG2133	pyrroloquinoline quinone binding
ASQ49_RS15640	COG2716	regulation of RNA biosynthetic process
ASQ49_RS15665	COG0477	Major facilitator Superfamily
ASQ49_RS15670	COG0477	Major facilitator Superfamily
ASQ49_RS15675	COG1028	Short-chain dehydrogenase reductase Sdr
ASQ49_RS15675	COG3321	synthase
ASQ49_RS15675	COG0604	alcohol dehydrogenase
ASQ49_RS15700	COG1335	isochorismatase
ASQ49_RS15705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ASQ49_RS15725	COG0406	alpha-ribazole phosphatase activity
ASQ49_RS15730	COG1132	(ABC) transporter
ASQ49_RS15745	COG1397	ADP-ribosylglycohydrolase
ASQ49_RS15765	COG3328	transposase activity
ASQ49_RS15820	COG3549	Plasmid maintenance system killer
ASQ49_RS15830	COG1131	(ABC) transporter
ASQ49_RS15835	COG3559	Exporter of polyketide antibiotics
ASQ49_RS15855	COG3549	Plasmid maintenance system killer
ASQ49_RS15925	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ASQ49_RS15935	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ASQ49_RS15940	COG0012	GTP binding
ASQ49_RS15965	COG1362	aminopeptidase activity
ASQ49_RS15970	COG1322	Protein conserved in bacteria
ASQ49_RS15975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ASQ49_RS15980	COG1570	exodeoxyribonuclease VII activity
ASQ49_RS15985	COG1722	exodeoxyribonuclease VII activity
ASQ49_RS15995	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ASQ49_RS16005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ASQ49_RS16010	COG1331	Highly conserved protein containing a thioredoxin domain
ASQ49_RS16025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ASQ49_RS16040	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ASQ49_RS16045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ASQ49_RS16080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ASQ49_RS16095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ASQ49_RS16100	COG0072	phenylalanine-tRNA ligase activity
ASQ49_RS16100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ASQ49_RS16105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ASQ49_RS16120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ASQ49_RS16125	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ASQ49_RS16130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ASQ49_RS16135	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ASQ49_RS16175	COG1834	amidinotransferase
ASQ49_RS16195	COG2837	iron assimilation
ASQ49_RS16225	COG0148	phosphopyruvate hydratase activity
ASQ49_RS16245	COG0193	aminoacyl-tRNA hydrolase activity
ASQ49_RS16250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ASQ49_RS16255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ASQ49_RS16260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ASQ49_RS16270	COG1309	transcriptional regulator
ASQ49_RS16275	COG1846	Transcriptional regulator
ASQ49_RS16280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ASQ49_RS16285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ASQ49_RS16290	COG0084	hydrolase, TatD family'
ASQ49_RS16305	COG2233	PERMEase
ASQ49_RS16315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ASQ49_RS16345	COG0657	acetylesterase activity
ASQ49_RS16360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ASQ49_RS16375	COG0693	protein deglycase activity
ASQ49_RS16385	COG0789	Transcriptional regulator
ASQ49_RS16415	COG1053	succinate dehydrogenase
ASQ49_RS16440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ASQ49_RS16455	COG0436	Aminotransferase
ASQ49_RS16505	COG2801	Transposase and inactivated derivatives
ASQ49_RS16515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD