locus-tag	class	description
DUY81_RS00065	COG3328	transposase activity
DUY81_RS00075	COG1904	glucuronate isomerase
DUY81_RS00080	COG2721	sulfolactate sulfo-lyase activity
DUY81_RS00090	COG1609	Transcriptional regulator
DUY81_RS00095	COG1414	Transcriptional regulator
DUY81_RS00100	COG0800	Aldolase
DUY81_RS00105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DUY81_RS00110	COG1482	cell wall glycoprotein biosynthetic process
DUY81_RS00120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DUY81_RS00170	COG0395	ABC-type sugar transport system, permease component
DUY81_RS00175	COG1653	transport
DUY81_RS00180	COG0584	glycerophosphoryl diester phosphodiesterase
DUY81_RS00185	COG1609	Transcriptional regulator
DUY81_RS00195	COG1285	pathogenesis
DUY81_RS00215	COG4948	Mandelate Racemase Muconate Lactonizing
DUY81_RS00225	COG0656	L-ascorbic acid biosynthetic process
DUY81_RS00235	COG1312	Catalyzes the dehydration of D-mannonate
DUY81_RS00240	COG0246	Mannitol dehydrogenase
DUY81_RS00245	COG1904	glucuronate isomerase
DUY81_RS00250	COG1609	Transcriptional regulator
DUY81_RS00260	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_RS00285	COG3942	CHAP domain
DUY81_RS00300	COG1129	ABC transporter
DUY81_RS00320	COG3386	PFAM SMP-30 Gluconolaconase
DUY81_RS00325	COG0352	thiamine-phosphate diphosphorylase activity
DUY81_RS00330	COG0352	thiamine-phosphate diphosphorylase activity
DUY81_RS00330	COG0351	phosphomethylpyrimidine kinase
DUY81_RS00330	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DUY81_RS00335	COG2364	Membrane
DUY81_RS00340	COG0315	cyclic pyranopterin monophosphate synthase activity
DUY81_RS00340	COG0521	Mo-molybdopterin cofactor biosynthetic process
DUY81_RS00345	COG0315	cyclic pyranopterin monophosphate synthase activity
DUY81_RS00355	COG0314	molybdopterin synthase activity
DUY81_RS00365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DUY81_RS00385	COG1140	nitrate reductase beta subunit
DUY81_RS00410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DUY81_RS00415	COG0633	Ferredoxin
DUY81_RS00415	COG0543	2 iron, 2 sulfur cluster binding
DUY81_RS00420	COG1151	hydroxylamine reductase activity
DUY81_RS00430	COG2337	Toxic component of a toxin-antitoxin (TA) module
DUY81_RS00460	COG0601	transmembrane transport
DUY81_RS00465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DUY81_RS00475	COG4166	transmembrane transport
DUY81_RS00485	COG0456	acetyltransferase
DUY81_RS00510	COG1484	DNA-dependent DNA replication
DUY81_RS00550	COG1484	DNA-dependent DNA replication
DUY81_RS00620	COG0783	Belongs to the Dps family
DUY81_RS00625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DUY81_RS00635	COG2217	Heavy metal translocating P-type atpase
DUY81_RS00645	COG3189	MarR family transcriptional regulator
DUY81_RS00685	COG0205	6-phosphofructokinase activity
DUY81_RS00710	COG0577	efflux transmembrane transporter activity
DUY81_RS00710	COG1136	(ABC) transporter
DUY81_RS00720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DUY81_RS00730	COG0511	ligase activity, forming carbon-carbon bonds
DUY81_RS00740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DUY81_RS00745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DUY81_RS00745	COG1042	CoA-binding domain protein
DUY81_RS00745	COG0045	succinate-CoA ligase (ADP-forming) activity
DUY81_RS00750	COG1254	Belongs to the acylphosphatase family
DUY81_RS00770	COG0281	malic enzyme
DUY81_RS00785	COG1321	iron dependent repressor
DUY81_RS00785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DUY81_RS00790	COG1914	H( )-stimulated, divalent metal cation uptake system
DUY81_RS00795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DUY81_RS00800	COG0477	Major facilitator Superfamily
DUY81_RS00810	COG2814	Major facilitator Superfamily
DUY81_RS00820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DUY81_RS00825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DUY81_RS00835	COG0438	transferase activity, transferring glycosyl groups
DUY81_RS00845	COG2409	Drug exporters of the RND superfamily
DUY81_RS00850	COG1309	transcriptional regulator
DUY81_RS00870	COG2022	thiamine diphosphate biosynthetic process
DUY81_RS00880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DUY81_RS00880	COG0596	Alpha beta hydrolase
DUY81_RS00885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DUY81_RS00920	COG0656	L-ascorbic acid biosynthetic process
DUY81_RS00945	COG0730	response to heat
DUY81_RS00960	COG0175	sulfate reduction
DUY81_RS00985	COG2132	Multicopper oxidase
DUY81_RS00995	COG0745	RESPONSE REGULATOR receiver
DUY81_RS01000	COG5002	protein histidine kinase activity
DUY81_RS01010	COG4585	Histidine kinase
DUY81_RS01015	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DUY81_RS01020	COG2205	protein histidine kinase activity
DUY81_RS01055	COG1132	(ABC) transporter
DUY81_RS01060	COG0477	Major facilitator Superfamily
DUY81_RS01065	COG1690	Belongs to the RtcB family
DUY81_RS01070	COG3657	addiction module killer protein
DUY81_RS01075	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DUY81_RS01090	COG2197	response regulator
DUY81_RS01095	COG1136	(ABC) transporter
DUY81_RS01120	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DUY81_RS01145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DUY81_RS01155	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_RS01220	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DUY81_RS01240	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DUY81_RS01245	COG0395	ABC-type sugar transport system, permease component
DUY81_RS01250	COG1175	transmembrane transport
DUY81_RS01255	COG1653	transport
DUY81_RS01265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DUY81_RS01270	COG1126	abc transporter atp-binding protein
DUY81_RS01275	COG0765	amino acid transport
DUY81_RS01280	COG0148	phosphopyruvate hydratase activity
DUY81_RS01285	COG0095	Lipoate-protein ligase
DUY81_RS01295	COG1131	(ABC) transporter
DUY81_RS01315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DUY81_RS01320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DUY81_RS01330	COG3775	system Galactitol-specific IIC component
DUY81_RS01335	COG3414	Phosphotransferase system galactitol-specific IIB component
DUY81_RS01340	COG1063	alcohol dehydrogenase
DUY81_RS01375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DUY81_RS01380	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_RS01390	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DUY81_RS01395	COG0039	L-malate dehydrogenase activity
DUY81_RS01400	COG0281	malic enzyme
DUY81_RS01415	COG0039	L-malate dehydrogenase activity
DUY81_RS01460	COG1396	sequence-specific DNA binding
DUY81_RS01465	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
DUY81_RS01500	COG1869	D-ribose catabolic process
DUY81_RS01505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DUY81_RS01515	COG1172	Belongs to the binding-protein-dependent transport system permease family
DUY81_RS01520	COG1129	ABC transporter
DUY81_RS01525	COG1609	Transcriptional regulator
DUY81_RS01535	COG3266	domain, Protein
DUY81_RS01540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DUY81_RS01545	COG0187	DNA topoisomerase II activity
DUY81_RS01555	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DUY81_RS01560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DUY81_RS01570	COG0592	DNA-directed DNA polymerase activity
DUY81_RS01575	COG0577	efflux transmembrane transporter activity
DUY81_RS01580	COG0577	efflux transmembrane transporter activity
DUY81_RS01580	COG1136	(ABC) transporter
DUY81_RS01585	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DUY81_RS01595	COG0594	ribonuclease P activity
DUY81_RS01605	COG0706	membrane insertase activity
DUY81_RS01620	COG0357	Ribosomal RNA small subunit methyltransferase G
DUY81_RS01625	COG3328	transposase activity
DUY81_RS01640	COG1793	dna ligase
DUY81_RS01640	COG3285	dna ligase
DUY81_RS01655	COG1181	Belongs to the D-alanine--D-alanine ligase family
DUY81_RS01660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DUY81_RS01680	COG1082	Xylose isomerase domain protein TIM barrel
DUY81_RS01685	COG0673	inositol 2-dehydrogenase activity
DUY81_RS01690	COG1082	Xylose isomerase domain protein TIM barrel
DUY81_RS01700	COG2814	Major facilitator Superfamily
DUY81_RS01710	COG2814	Major facilitator Superfamily
DUY81_RS01715	COG0673	inositol 2-dehydrogenase activity
DUY81_RS01725	COG0673	inositol 2-dehydrogenase activity
DUY81_RS01730	COG1082	Xylose isomerase domain protein TIM barrel
DUY81_RS01735	COG2855	membrane
DUY81_RS01745	COG1609	Transcriptional regulator
DUY81_RS01750	COG0673	inositol 2-dehydrogenase activity
DUY81_RS01755	COG1082	Xylose isomerase domain protein TIM barrel
DUY81_RS01765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DUY81_RS01780	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DUY81_RS01780	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
DUY81_RS01795	COG1660	Displays ATPase and GTPase activities
DUY81_RS01805	COG0626	cystathionine gamma-synthase activity
DUY81_RS01815	COG2124	cytochrome p450
DUY81_RS01830	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DUY81_RS01840	COG0142	geranyltranstransferase activity
DUY81_RS01855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DUY81_RS01875	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DUY81_RS01900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DUY81_RS01920	COG3328	transposase activity
DUY81_RS01950	COG0564	pseudouridine synthase activity
DUY81_RS01960	COG1733	regulation of RNA biosynthetic process
DUY81_RS01970	COG1609	Transcriptional regulator
DUY81_RS01990	COG0395	ABC-type sugar transport system, permease component
DUY81_RS02005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DUY81_RS02015	COG2390	Transcriptional regulator
DUY81_RS02020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DUY81_RS02025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DUY81_RS02035	COG1595	DNA-templated transcription, initiation
DUY81_RS02040	COG2815	serine threonine protein kinase
DUY81_RS02040	COG0515	serine threonine protein kinase
DUY81_RS02060	COG0385	Bile acid
DUY81_RS02065	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_RS02080	COG1929	Belongs to the glycerate kinase type-1 family
DUY81_RS02085	COG0668	transmembrane transport
DUY81_RS02100	COG0540	Belongs to the ATCase OTCase family
DUY81_RS02105	COG1349	DNA-binding transcription factor activity
DUY81_RS02110	COG2814	Major facilitator Superfamily
DUY81_RS02145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DUY81_RS02150	COG0114	fumarate hydratase activity
DUY81_RS02160	COG3830	Belongs to the UPF0237 family
DUY81_RS02165	COG2848	UPF0210 protein
DUY81_RS02175	COG0038	chloride channel
DUY81_RS02215	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DUY81_RS02225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DUY81_RS02230	COG1376	ErfK ybiS ycfS ynhG family protein
DUY81_RS02270	COG2267	carboxylic ester hydrolase activity
DUY81_RS02275	COG0686	Belongs to the AlaDH PNT family
DUY81_RS02280	COG0205	6-phosphofructokinase activity
DUY81_RS02290	COG0515	serine threonine protein kinase
DUY81_RS02295	COG0842	Transport permease protein
DUY81_RS02295	COG1131	(ABC) transporter
DUY81_RS02295	COG1716	ATPase activity
DUY81_RS02300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DUY81_RS02305	COG2146	nitrite reductase [NAD(P)H] activity
DUY81_RS02315	COG3609	addiction module antidote protein, CC2985 family
DUY81_RS02320	COG2337	Toxic component of a toxin-antitoxin (TA) module
DUY81_RS02350	COG1733	regulation of RNA biosynthetic process
DUY81_RS02355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DUY81_RS02370	COG1609	Transcriptional regulator
DUY81_RS02380	COG1175	transmembrane transport
DUY81_RS02390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DUY81_RS02400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DUY81_RS02540	COG1113	amino acid transport
DUY81_RS02555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DUY81_RS02560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DUY81_RS02565	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
DUY81_RS02570	COG0247	lactate metabolic process
DUY81_RS02575	COG4585	Histidine kinase
DUY81_RS02580	COG0277	FAD linked oxidase domain protein
DUY81_RS02625	COG0300	oxidoreductase activity
DUY81_RS02640	COG1022	Amp-dependent synthetase and ligase
DUY81_RS02650	COG0672	)-iron permease
DUY81_RS02655	COG2822	iron ion transport
DUY81_RS02660	COG2837	iron assimilation
DUY81_RS02665	COG0360	Binds together with S18 to 16S ribosomal RNA
DUY81_RS02675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DUY81_RS02680	COG0359	binds to the 23S rRNA
DUY81_RS02690	COG1968	undecaprenyl-diphosphatase activity
DUY81_RS02725	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DUY81_RS02735	COG2205	protein histidine kinase activity
DUY81_RS02750	COG1609	Transcriptional regulator
DUY81_RS02760	COG1175	transmembrane transport
DUY81_RS02765	COG0395	ABC-type sugar transport system, permease component
DUY81_RS02785	COG2423	ornithine cyclodeaminase activity
DUY81_RS02800	COG1132	(ABC) transporter
DUY81_RS02820	COG0366	Alpha amylase catalytic
DUY81_RS02825	COG0395	ABC-type sugar transport system, permease component
DUY81_RS02830	COG1175	transmembrane transport
DUY81_RS02840	COG1940	carbohydrate kinase activity
DUY81_RS02860	COG1285	pathogenesis
DUY81_RS02865	COG1175	transmembrane transport
DUY81_RS02870	COG0395	ABC-type sugar transport system, permease component
DUY81_RS02885	COG1472	Belongs to the glycosyl hydrolase 3 family
DUY81_RS02910	COG0366	Alpha amylase catalytic
DUY81_RS02920	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DUY81_RS02975	COG0477	Major facilitator Superfamily
DUY81_RS02980	COG1621	beta-fructofuranosidase activity
DUY81_RS02995	COG5002	protein histidine kinase activity
DUY81_RS03005	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DUY81_RS03005	COG3976	FMN-binding domain protein
DUY81_RS03025	COG1715	Restriction endonuclease
DUY81_RS03070	COG0765	amino acid transport
DUY81_RS03075	COG0765	amino acid transport
DUY81_RS03080	COG1126	abc transporter atp-binding protein
DUY81_RS03100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DUY81_RS03105	COG0154	amidase activity
DUY81_RS03135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DUY81_RS03145	COG0006	proline dipeptidase activity
DUY81_RS03150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DUY81_RS03160	COG0477	Major facilitator Superfamily
DUY81_RS03180	COG0535	radical SAM domain protein
DUY81_RS03185	COG1233	COG1233 Phytoene dehydrogenase and related
DUY81_RS03195	COG0022	dehydrogenase e1 component
DUY81_RS03200	COG0508	dehydrogenase complex catalyzes the overall conversion of
DUY81_RS03210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DUY81_RS03220	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DUY81_RS03240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DUY81_RS03260	COG0395	ABC-type sugar transport system, permease component
DUY81_RS03275	COG1609	Transcriptional regulator
DUY81_RS03280	COG0561	phosphatase activity
DUY81_RS03300	COG0137	argininosuccinate synthase activity
DUY81_RS03305	COG1028	Short-chain dehydrogenase reductase Sdr
DUY81_RS03305	COG3321	synthase
DUY81_RS03305	COG0604	alcohol dehydrogenase
DUY81_RS03330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DUY81_RS03335	COG1609	Transcriptional regulator
DUY81_RS03340	COG1316	TRANSCRIPTIONal
DUY81_RS03365	COG0584	glycerophosphoryl diester phosphodiesterase
DUY81_RS03370	COG1506	peptidase
DUY81_RS03370	COG0823	Involved in the tonB-independent uptake of proteins
DUY81_RS03370	COG4946	Tricorn protease homolog
DUY81_RS03375	COG2130	NADP-dependent
DUY81_RS03400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DUY81_RS03445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DUY81_RS03455	COG1174	glycine betaine transport
DUY81_RS03465	COG1125	glycine betaine transport
DUY81_RS03465	COG0517	IMP dehydrogenase activity
DUY81_RS03470	COG3263	regulation of cellular component size
DUY81_RS03485	COG0433	COG0433 Predicted ATPase
DUY81_RS03505	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DUY81_RS03515	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DUY81_RS03535	COG1942	4-Oxalocrotonate Tautomerase
DUY81_RS03540	COG0673	inositol 2-dehydrogenase activity
DUY81_RS03550	COG1946	Acyl-CoA thioesterase
DUY81_RS03555	COG2376	Dihydroxyacetone kinase
DUY81_RS03560	COG1063	alcohol dehydrogenase
DUY81_RS03565	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DUY81_RS03575	COG1064	alcohol dehydrogenase
DUY81_RS03585	COG0390	transport system, permease component
DUY81_RS03595	COG1968	undecaprenyl-diphosphatase activity
DUY81_RS03600	COG0745	RESPONSE REGULATOR receiver
DUY81_RS03610	COG0438	transferase activity, transferring glycosyl groups
DUY81_RS03620	COG0586	Pfam SNARE associated Golgi protein
DUY81_RS03635	COG0183	Belongs to the thiolase family
DUY81_RS03645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DUY81_RS03655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DUY81_RS03670	COG0402	S-adenosylhomocysteine deaminase activity
DUY81_RS03705	COG0395	ABC-type sugar transport system, permease component
DUY81_RS03710	COG1175	transmembrane transport
DUY81_RS03715	COG1653	transport
DUY81_RS03740	COG1609	Transcriptional regulator
DUY81_RS03765	COG1468	defense response to virus
DUY81_RS03765	COG1518	maintenance of DNA repeat elements
DUY81_RS03815	COG3158	transport of potassium into the cell
DUY81_RS03835	COG4572	Cation transport regulator
DUY81_RS03855	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DUY81_RS03880	COG1295	ribonuclease BN
DUY81_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
DUY81_RS03895	COG0783	Belongs to the Dps family
DUY81_RS03905	COG1028	Short-chain dehydrogenase reductase Sdr
DUY81_RS03910	COG2124	cytochrome p450
DUY81_RS03915	COG3285	dna ligase
DUY81_RS03915	COG1793	dna ligase
DUY81_RS03930	COG0753	catalase activity
DUY81_RS03935	COG2197	response regulator
DUY81_RS03945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DUY81_RS03945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DUY81_RS03980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DUY81_RS03985	COG0534	Mate efflux family protein
DUY81_RS03995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DUY81_RS04015	COG1072	(Pantothenic acid kinase))
DUY81_RS04020	COG1069	ribulokinase activity
DUY81_RS04025	COG0657	acetylesterase activity
DUY81_RS04035	COG3022	response to hydroperoxide
DUY81_RS04050	COG4608	Belongs to the ABC transporter superfamily
DUY81_RS04055	COG0444	Belongs to the ABC transporter superfamily
DUY81_RS04060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DUY81_RS04065	COG0601	transmembrane transport
DUY81_RS04100	COG2040	homocysteine
DUY81_RS04125	COG1408	metallophosphoesterase
DUY81_RS04130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DUY81_RS04165	COG0494	nUDIX hydrolase
DUY81_RS04240	COG2026	Addiction module toxin, RelE StbE family
DUY81_RS04255	COG1111	helicase
DUY81_RS04255	COG1205	dead DEAH box helicase
DUY81_RS04260	COG2890	protein-(glutamine-N5) methyltransferase activity
DUY81_RS04270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DUY81_RS04270	COG1754	DNA topoisomerase type I activity
DUY81_RS04280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DUY81_RS04285	COG0470	DNA polymerase III
DUY81_RS04295	COG1774	PSP1 C-terminal conserved region
DUY81_RS04335	COG1231	oxidoreductase activity
DUY81_RS04340	COG0431	NADPH-dependent FMN reductase
DUY81_RS04370	COG0601	transmembrane transport
DUY81_RS04375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DUY81_RS04380	COG4172	Belongs to the ABC transporter superfamily
DUY81_RS04385	COG1619	proteins homologs of microcin C7 resistance protein MccF
DUY81_RS04390	COG1522	sequence-specific DNA binding
DUY81_RS04435	COG2062	phosphohistidine phosphatase, SixA
DUY81_RS04440	COG3458	cephalosporin-C deacetylase activity
DUY81_RS04450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DUY81_RS04460	COG0037	tRNA processing
DUY81_RS04475	COG0302	gtp cyclohydrolase
DUY81_RS04480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DUY81_RS04485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DUY81_RS04490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DUY81_RS04505	COG0649	NAD binding
DUY81_RS04575	COG0705	Rhomboid family
DUY81_RS04575	COG0457	Tetratricopeptide repeat
DUY81_RS04585	COG4143	(ABC) transporter
DUY81_RS04595	COG3842	ATPase activity
DUY81_RS04610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DUY81_RS04615	COG0113	porphobilinogen synthase activity
DUY81_RS04625	COG0181	hydroxymethylbilane synthase activity
DUY81_RS04635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DUY81_RS04640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DUY81_RS04645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DUY81_RS04645	COG3253	May function as heme-dependent peroxidase
DUY81_RS04655	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DUY81_RS04660	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DUY81_RS04675	COG1082	Xylose isomerase domain protein TIM barrel
DUY81_RS04680	COG0506	proline dehydrogenase activity
DUY81_RS04710	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DUY81_RS04720	COG0406	alpha-ribazole phosphatase activity
DUY81_RS04725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DUY81_RS04730	COG0785	Cytochrome C biogenesis protein
DUY81_RS04740	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DUY81_RS04760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DUY81_RS04775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DUY81_RS04780	COG0129	dihydroxy-acid dehydratase activity
DUY81_RS04800	COG1120	ATPase activity
DUY81_RS04805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DUY81_RS04810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DUY81_RS04815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DUY81_RS04820	COG0803	Belongs to the bacterial solute-binding protein 9 family
DUY81_RS04830	COG1121	(ABC) transporter
DUY81_RS04835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DUY81_RS04850	COG0523	cobalamin synthesis protein
DUY81_RS04855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DUY81_RS04860	COG0254	rRNA binding
DUY81_RS04865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DUY81_RS04875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DUY81_RS04880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DUY81_RS04900	COG0406	alpha-ribazole phosphatase activity
DUY81_RS04900	COG0494	nUDIX hydrolase
DUY81_RS04905	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DUY81_RS04910	COG0745	RESPONSE REGULATOR receiver
DUY81_RS04940	COG1490	D-aminoacyl-tRNA deacylase activity
DUY81_RS04945	COG3485	protocatechuate 3,4-dioxygenase
DUY81_RS04955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DUY81_RS04965	COG1217	gtp-binding protein TYPA
DUY81_RS04970	COG2337	Toxic component of a toxin-antitoxin (TA) module
DUY81_RS04985	COG0446	pyridine nucleotide-disulphide oxidoreductase
DUY81_RS04990	COG1937	Protein conserved in bacteria
DUY81_RS05005	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DUY81_RS05010	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
DUY81_RS05015	COG4423	Transcription factor
DUY81_RS05020	COG0151	Belongs to the GarS family
DUY81_RS05025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DUY81_RS05035	COG3634	alkyl hydroperoxide reductase activity
DUY81_RS05045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DUY81_RS05050	COG0047	phosphoribosylformylglycinamidine synthase activity
DUY81_RS05055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DUY81_RS05065	COG1113	amino acid transport
DUY81_RS05070	COG0252	asparaginase activity
DUY81_RS05085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DUY81_RS05125	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DUY81_RS05145	COG1175	transmembrane transport
DUY81_RS05150	COG0395	ABC-type sugar transport system, permease component
DUY81_RS05270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DUY81_RS05285	COG0574	Belongs to the PEP-utilizing enzyme family
DUY81_RS05285	COG3848	Pyruvate phosphate dikinase
DUY81_RS05330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DUY81_RS05340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DUY81_RS05360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DUY81_RS05380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DUY81_RS05380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DUY81_RS05380	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DUY81_RS05385	COG1461	Dihydroxyacetone kinase
DUY81_RS05390	COG2376	Dihydroxyacetone kinase
DUY81_RS05410	COG1132	(ABC) transporter
DUY81_RS05420	COG2226	methyltransferase
DUY81_RS05425	COG1131	(ABC) transporter
DUY81_RS05455	COG0644	oxidoreductase
DUY81_RS05465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_RS05470	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_RS05475	COG0649	NAD binding
DUY81_RS05485	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DUY81_RS05490	COG1034	ATP synthesis coupled electron transport
DUY81_RS05495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DUY81_RS05500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_RS05510	COG0713	ATP synthesis coupled electron transport
DUY81_RS05525	COG1007	ATP synthesis coupled electron transport
DUY81_RS05530	COG0142	geranyltranstransferase activity
DUY81_RS05580	COG3590	peptidase
DUY81_RS05585	COG1013	pyruvate-flavodoxin oxidoreductase activity
DUY81_RS05590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DUY81_RS05590	COG0674	pyruvate-flavodoxin oxidoreductase activity
DUY81_RS05595	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_RS05600	COG0649	NAD binding
DUY81_RS05600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_RS05605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DUY81_RS05645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DUY81_RS05650	COG2030	dehydratase
DUY81_RS05660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DUY81_RS05665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DUY81_RS05680	COG0250	Participates in transcription elongation, termination and antitermination
DUY81_RS05685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DUY81_RS05690	COG0081	regulation of translation
DUY81_RS05695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DUY81_RS05700	COG0222	ribosome binding
DUY81_RS05705	COG0085	RNA polymerase activity
DUY81_RS05710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DUY81_RS05725	COG0673	inositol 2-dehydrogenase activity
DUY81_RS05730	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DUY81_RS05735	COG0049	tRNA binding
DUY81_RS05740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DUY81_RS05745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DUY81_RS05760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DUY81_RS05765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DUY81_RS05770	COG0051	transcription antitermination factor activity, RNA binding
DUY81_RS05775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DUY81_RS05780	COG0088	Forms part of the polypeptide exit tunnel
DUY81_RS05785	COG0089	rRNA binding
DUY81_RS05790	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DUY81_RS05795	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DUY81_RS05800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DUY81_RS05805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DUY81_RS05810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DUY81_RS05815	COG0255	Belongs to the universal ribosomal protein uL29 family
DUY81_RS05820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DUY81_RS05840	COG1175	transmembrane transport
DUY81_RS05845	COG0395	ABC-type sugar transport system, permease component
DUY81_RS05850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DUY81_RS05855	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DUY81_RS05860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DUY81_RS05865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DUY81_RS05870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DUY81_RS05875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DUY81_RS05880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DUY81_RS05885	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DUY81_RS05890	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DUY81_RS05895	COG1841	ribosomal large subunit assembly
DUY81_RS05900	COG0200	Binds to the 23S rRNA
DUY81_RS05935	COG0563	adenylate kinase activity
DUY81_RS05955	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DUY81_RS05960	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DUY81_RS05970	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DUY81_RS05975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DUY81_RS05980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DUY81_RS05985	COG0202	RNA polymerase activity
DUY81_RS05990	COG0203	ribosomal protein L17
DUY81_RS05995	COG0438	transferase activity, transferring glycosyl groups
DUY81_RS06005	COG0519	Catalyzes the synthesis of GMP from XMP
DUY81_RS06005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DUY81_RS06020	COG3845	ABC transporter
DUY81_RS06025	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DUY81_RS06040	COG0101	tRNA pseudouridine synthase activity
DUY81_RS06045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DUY81_RS06055	COG2814	Major facilitator Superfamily
DUY81_RS06065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DUY81_RS06070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DUY81_RS06080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DUY81_RS06090	COG1072	(Pantothenic acid kinase))
DUY81_RS06100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DUY81_RS06105	COG0736	holo-[acyl-carrier-protein] synthase activity
DUY81_RS06120	COG0513	Belongs to the DEAD box helicase family
DUY81_RS06125	COG0802	atpase or kinase
DUY81_RS06130	COG1214	PFAM Peptidase M22, glycoprotease
DUY81_RS06130	COG0456	acetyltransferase
DUY81_RS06140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DUY81_RS06160	COG1355	regulation of microtubule-based process
DUY81_RS06180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DUY81_RS06185	COG0459	protein refolding
DUY81_RS06205	COG1605	Chorismate mutase
DUY81_RS06205	COG0287	Prephenate dehydrogenase
DUY81_RS06210	COG1045	serine acetyltransferase
DUY81_RS06215	COG0519	Catalyzes the synthesis of GMP from XMP
DUY81_RS06215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DUY81_RS06240	COG2197	response regulator
DUY81_RS06245	COG2261	transglycosylase associated protein
DUY81_RS06255	COG2011	ABC-type metal ion transport system permease component
DUY81_RS06260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DUY81_RS06265	COG1464	Belongs to the NlpA lipoprotein family
DUY81_RS06280	COG0045	succinate-CoA ligase (ADP-forming) activity
DUY81_RS06310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DUY81_RS06310	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DUY81_RS06315	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DUY81_RS06325	COG0138	bifunctional purine biosynthesis protein purh
DUY81_RS06335	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DUY81_RS06350	COG0039	L-malate dehydrogenase activity
DUY81_RS06370	COG1253	flavin adenine dinucleotide binding
DUY81_RS06390	COG3845	ABC transporter
DUY81_RS06395	COG4603	Belongs to the binding-protein-dependent transport system permease family
DUY81_RS06400	COG1079	Belongs to the binding-protein-dependent transport system permease family
DUY81_RS06410	COG0328	RNA-DNA hybrid ribonuclease activity
DUY81_RS06415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DUY81_RS06435	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DUY81_RS06445	COG5275	peptidyl-tyrosine sulfation
DUY81_RS06445	COG0252	asparaginase activity
DUY81_RS06450	COG4656	Part of a membrane complex involved in electron transport
DUY81_RS06455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DUY81_RS06470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DUY81_RS06490	COG4770	biotin carboxylase activity
DUY81_RS06500	COG0351	phosphomethylpyrimidine kinase
DUY81_RS06510	COG4221	oxidoreductase activity
DUY81_RS06525	COG0424	maF-like protein
DUY81_RS06535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DUY81_RS06545	COG3340	Belongs to the peptidase S51 family
DUY81_RS06565	COG1316	TRANSCRIPTIONal
DUY81_RS06580	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DUY81_RS06580	COG0662	Cupin 2, conserved barrel domain protein
DUY81_RS06630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DUY81_RS06660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DUY81_RS06675	COG1918	ferrous iron import across plasma membrane
DUY81_RS06675	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DUY81_RS06685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DUY81_RS06690	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DUY81_RS06695	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DUY81_RS06700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DUY81_RS06710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DUY81_RS06735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DUY81_RS06760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DUY81_RS06775	COG0587	DNA-directed DNA polymerase activity
DUY81_RS06785	COG0531	amino acid
DUY81_RS06790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DUY81_RS06810	COG1131	(ABC) transporter
DUY81_RS06825	COG1113	amino acid transport
DUY81_RS06835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DUY81_RS06845	COG4585	Histidine kinase
DUY81_RS06850	COG2197	response regulator
DUY81_RS06855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DUY81_RS06865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DUY81_RS06890	COG1794	racemase activity, acting on amino acids and derivatives
DUY81_RS06895	COG0519	Catalyzes the synthesis of GMP from XMP
DUY81_RS06905	COG4106	trans-aconitate 2-methyltransferase activity
DUY81_RS06915	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DUY81_RS06930	COG0629	single-stranded DNA binding
DUY81_RS06940	COG0247	lactate metabolic process
DUY81_RS06940	COG0277	FAD linked oxidase domain protein
DUY81_RS06955	COG1022	Amp-dependent synthetase and ligase
DUY81_RS06970	COG2814	Major facilitator Superfamily
DUY81_RS06980	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DUY81_RS06995	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DUY81_RS07000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DUY81_RS07015	COG0698	ribose 5-phosphate isomerase
DUY81_RS07035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DUY81_RS07035	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DUY81_RS07055	COG0544	peptidyl-prolyl cis-trans isomerase activity
DUY81_RS07065	COG0740	serine-type endopeptidase activity
DUY81_RS07070	COG0740	serine-type endopeptidase activity
DUY81_RS07075	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DUY81_RS07085	COG0793	Belongs to the peptidase S41A family
DUY81_RS07085	COG4946	Tricorn protease homolog
DUY81_RS07100	COG0525	valine-tRNA ligase activity
DUY81_RS07110	COG0363	glucosamine-6-phosphate deaminase activity
DUY81_RS07125	COG0109	protoheme IX farnesyltransferase activity
DUY81_RS07130	COG1612	heme a metabolic process
DUY81_RS07140	COG1131	(ABC) transporter
DUY81_RS07145	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DUY81_RS07150	COG1609	Transcriptional regulator
DUY81_RS07155	COG3833	ABC-type maltose transport systems, permease component
DUY81_RS07160	COG1175	transmembrane transport
DUY81_RS07190	COG0396	ATPase activity
DUY81_RS07195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DUY81_RS07230	COG0110	maltose O-acetyltransferase activity
DUY81_RS07245	COG0488	(ABC) transporter
DUY81_RS07275	COG1028	Short-chain dehydrogenase reductase Sdr
DUY81_RS07300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DUY81_RS07305	COG1119	ATPase activity
DUY81_RS07345	COG0242	peptide deformylase activity
DUY81_RS07355	COG4974	Belongs to the 'phage' integrase family
DUY81_RS07370	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DUY81_RS07385	COG3831	ATPase activity
DUY81_RS07390	COG0052	Belongs to the universal ribosomal protein uS2 family
DUY81_RS07395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DUY81_RS07400	COG0528	UMP kinase activity
DUY81_RS07405	COG0233	cytoplasmic translational termination
DUY81_RS07410	COG0575	Belongs to the CDS family
DUY81_RS07415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DUY81_RS07420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DUY81_RS07430	COG0750	zinc metalloprotease
DUY81_RS07435	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DUY81_RS07465	COG1305	Transglutaminase-like
DUY81_RS07475	COG0442	prolyl-tRNA aminoacylation
DUY81_RS07495	COG0779	Required for maturation of 30S ribosomal subunits
DUY81_RS07500	COG0195	Participates in both transcription termination and antitermination
DUY81_RS07510	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DUY81_RS07520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DUY81_RS07525	COG0371	Dehydrogenase
DUY81_RS07540	COG3732	PTS system glucitol sorbitol-specific
DUY81_RS07560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DUY81_RS07580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DUY81_RS07585	COG1185	polyribonucleotide nucleotidyltransferase activity
DUY81_RS07590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DUY81_RS07600	COG0028	Belongs to the TPP enzyme family
DUY81_RS07610	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DUY81_RS07615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DUY81_RS07635	COG0742	ribosomal rna small subunit methyltransferase
DUY81_RS07640	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DUY81_RS07650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DUY81_RS07655	COG0571	ribonuclease III activity
DUY81_RS07660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DUY81_RS07665	COG0656	L-ascorbic acid biosynthetic process
DUY81_RS07740	COG0228	four-way junction DNA binding
DUY81_RS07745	COG1837	Belongs to the UPF0109 family
DUY81_RS07750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DUY81_RS07755	COG0336	Belongs to the RNA methyltransferase TrmD family
DUY81_RS07765	COG1053	succinate dehydrogenase
DUY81_RS07770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DUY81_RS07775	COG0335	large ribosomal subunit rRNA binding
DUY81_RS07780	COG0681	Belongs to the peptidase S26 family
DUY81_RS07785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DUY81_RS07795	COG0792	nuclease activity
DUY81_RS07825	COG1175	transmembrane transport
DUY81_RS07830	COG0395	ABC-type sugar transport system, permease component
DUY81_RS07835	COG1609	Transcriptional regulator
DUY81_RS07845	COG0395	ABC-type sugar transport system, permease component
DUY81_RS07875	COG2160	L-arabinose isomerase activity
DUY81_RS07880	COG1609	Transcriptional regulator
DUY81_RS07890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DUY81_RS07900	COG0667	Aldo Keto reductase
DUY81_RS07910	COG3201	nicotinamide mononucleotide transporter
DUY81_RS07915	COG0140	phosphoribosyl-ATP diphosphatase activity
DUY81_RS07920	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DUY81_RS07960	COG0735	belongs to the Fur family
DUY81_RS07970	COG0423	glycine-tRNA ligase activity
DUY81_RS07980	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DUY81_RS07995	COG0076	glutamate decarboxylase activity
DUY81_RS08005	COG1053	succinate dehydrogenase
DUY81_RS08010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DUY81_RS08035	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DUY81_RS08040	COG0358	DNA primase activity
DUY81_RS08045	COG1191	sigma factor activity
DUY81_RS08065	COG0488	(ABC) transporter
DUY81_RS08070	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DUY81_RS08090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DUY81_RS08100	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DUY81_RS08110	COG0583	DNA-binding transcription factor activity
DUY81_RS08120	COG0515	serine threonine protein kinase
DUY81_RS08130	COG0477	Major facilitator Superfamily
DUY81_RS08160	COG0714	Associated with various cellular activities
DUY81_RS08170	COG2304	oxidoreductase activity
DUY81_RS08195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DUY81_RS08200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DUY81_RS08210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DUY81_RS08225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DUY81_RS08235	COG0667	Aldo Keto reductase
DUY81_RS08250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DUY81_RS08255	COG0505	Belongs to the CarA family
DUY81_RS08260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DUY81_RS08265	COG0543	2 iron, 2 sulfur cluster binding
DUY81_RS08270	COG0167	dihydroorotate dehydrogenase activity
DUY81_RS08275	COG0284	orotidine-5'-phosphate decarboxylase activity
DUY81_RS08280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DUY81_RS08310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DUY81_RS08320	COG1546	Belongs to the CinA family
DUY81_RS08320	COG1058	Belongs to the CinA family
DUY81_RS08330	COG1349	DNA-binding transcription factor activity
DUY81_RS08345	COG2137	regulation of response to DNA damage stimulus
DUY81_RS08350	COG1418	mRNA catabolic process
DUY81_RS08355	COG2017	converts alpha-aldose to the beta-anomer
DUY81_RS08360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DUY81_RS08685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DUY81_RS08690	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DUY81_RS08695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DUY81_RS08710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DUY81_RS08715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DUY81_RS08720	COG0717	Belongs to the dCTP deaminase family
DUY81_RS08740	COG1643	Atp-dependent helicase
DUY81_RS08750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DUY81_RS08765	COG0187	DNA topoisomerase II activity
DUY81_RS08785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DUY81_RS08795	COG1297	OPT oligopeptide transporter protein
DUY81_RS08830	COG0756	dUTP diphosphatase activity
DUY81_RS08850	COG0569	domain protein
DUY81_RS08855	COG0531	amino acid
DUY81_RS08860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DUY81_RS08870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DUY81_RS08875	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DUY81_RS08890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DUY81_RS08895	COG2326	polyphosphate kinase activity
DUY81_RS08925	COG0726	polysaccharide deacetylase
DUY81_RS08950	COG1064	alcohol dehydrogenase
DUY81_RS08955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DUY81_RS08965	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DUY81_RS08970	COG1560	Kdo2-lipid A biosynthetic process
DUY81_RS08975	COG0438	transferase activity, transferring glycosyl groups
DUY81_RS09005	COG1716	ATPase activity
DUY81_RS09030	COG0205	6-phosphofructokinase activity
DUY81_RS09040	COG0009	L-threonylcarbamoyladenylate synthase
DUY81_RS09045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DUY81_RS09050	COG1597	lipid kinase activity
DUY81_RS09055	COG1472	Belongs to the glycosyl hydrolase 3 family
DUY81_RS09060	COG1739	Uncharacterized protein family UPF0029
DUY81_RS09075	COG0443	Heat shock 70 kDa protein
DUY81_RS09110	COG0531	amino acid
DUY81_RS09125	COG1966	Carbon starvation protein
DUY81_RS09135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DUY81_RS09140	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DUY81_RS09155	COG1216	Glycosyl transferase, family 2
DUY81_RS09160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DUY81_RS09165	COG1522	sequence-specific DNA binding
DUY81_RS09170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DUY81_RS09170	COG2813	Specifically methylates the guanine in position
DUY81_RS09175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DUY81_RS09180	COG0427	acetyl-CoA hydrolase
DUY81_RS09200	COG2807	transmembrane transport
DUY81_RS09230	COG3550	peptidyl-serine autophosphorylation
DUY81_RS09275	COG3226	Transcriptional regulator
DUY81_RS09290	COG0277	FAD linked oxidase domain protein
DUY81_RS09300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DUY81_RS09320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DUY81_RS09330	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DUY81_RS09355	COG3328	transposase activity
DUY81_RS09430	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DUY81_RS09455	COG1764	response to oxidative stress
DUY81_RS09465	COG1160	GTP binding
DUY81_RS09470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DUY81_RS09480	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DUY81_RS09485	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DUY81_RS09500	COG0646	methionine synthase
DUY81_RS09500	COG1410	methionine synthase
DUY81_RS09510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DUY81_RS09520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DUY81_RS09530	COG2801	Transposase and inactivated derivatives
DUY81_RS09555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DUY81_RS09560	COG1201	RNA secondary structure unwinding
DUY81_RS09565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DUY81_RS09575	COG1758	RNA polymerase activity
DUY81_RS09580	COG0194	GDP metabolic process
DUY81_RS09590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DUY81_RS09595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DUY81_RS09605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DUY81_RS09610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DUY81_RS09615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DUY81_RS09620	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DUY81_RS09625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DUY81_RS09630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DUY81_RS09635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DUY81_RS09670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DUY81_RS09685	COG1309	transcriptional regulator
DUY81_RS09695	COG0124	histidyl-tRNA synthetase
DUY81_RS09700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DUY81_RS09705	COG1196	nuclear chromosome segregation
DUY81_RS09710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DUY81_RS09715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DUY81_RS09725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DUY81_RS09730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DUY81_RS09735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DUY81_RS09745	COG2255	four-way junction helicase activity
DUY81_RS09750	COG0632	four-way junction helicase activity
DUY81_RS09755	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DUY81_RS09760	COG0217	transcriptional regulatory protein
DUY81_RS09765	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DUY81_RS09770	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DUY81_RS09775	COG0131	Imidazoleglycerol-phosphate dehydratase
DUY81_RS09780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DUY81_RS09785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DUY81_RS09820	COG0395	ABC-type sugar transport system, permease component
DUY81_RS09840	COG0069	glutamate synthase activity
DUY81_RS09840	COG0067	glutamate synthase
DUY81_RS09840	COG0070	glutamate synthase
DUY81_RS09845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DUY81_RS09850	COG0159	tryptophan synthase activity
DUY81_RS09860	COG0134	indole-3-glycerol-phosphate synthase activity
DUY81_RS09875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DUY81_RS09880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DUY81_RS09895	COG2233	PERMEase
DUY81_RS09900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DUY81_RS09905	COG0154	amidase activity
DUY81_RS09910	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DUY81_RS09925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DUY81_RS09935	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DUY81_RS09950	COG0482	sulfurtransferase activity
DUY81_RS09970	COG0366	Alpha amylase catalytic
DUY81_RS09975	COG3281	Trehalose synthase
DUY81_RS09980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DUY81_RS09995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DUY81_RS10005	COG0033	Phosphoglucomutase
DUY81_RS10060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DUY81_RS10065	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DUY81_RS10070	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DUY81_RS10075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DUY81_RS10080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DUY81_RS10085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DUY81_RS10090	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DUY81_RS10095	COG0356	it plays a direct role in the translocation of protons across the membrane
DUY81_RS10110	COG1045	serine acetyltransferase
DUY81_RS10120	COG0367	asparagine synthase
DUY81_RS10125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DUY81_RS10135	COG0318	PFAM AMP-dependent synthetase and ligase
DUY81_RS10205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DUY81_RS10215	COG2890	protein-(glutamine-N5) methyltransferase activity
DUY81_RS10220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DUY81_RS10225	COG0254	rRNA binding
DUY81_RS10235	COG0083	homoserine kinase activity
DUY81_RS10240	COG0460	homoserine dehydrogenase
DUY81_RS10245	COG0019	diaminopimelate decarboxylase activity
DUY81_RS10255	COG1611	Belongs to the LOG family
DUY81_RS10265	COG0508	dehydrogenase complex catalyzes the overall conversion of
DUY81_RS10265	COG0567	Dehydrogenase, E1 component
DUY81_RS10290	COG1595	DNA-templated transcription, initiation
DUY81_RS10300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DUY81_RS10305	COG1162	GTPase activity
DUY81_RS10315	COG0483	inositol monophosphate 1-phosphatase activity
DUY81_RS10320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DUY81_RS10335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DUY81_RS10345	COG0747	negative chemotaxis
DUY81_RS10365	COG1472	Belongs to the glycosyl hydrolase 3 family
DUY81_RS10375	COG1615	UPF0182 protein
DUY81_RS10385	COG3480	Lon protease (S16) C-terminal proteolytic domain
DUY81_RS10410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DUY81_RS10415	COG1074	ATP-dependent DNA helicase activity
DUY81_RS10420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DUY81_RS10440	COG1278	Cold shock
DUY81_RS10465	COG0180	Tryptophanyl-tRNA synthetase
DUY81_RS10475	COG0613	PHP domain protein
DUY81_RS10495	COG0653	protein targeting
DUY81_RS10505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DUY81_RS10515	COG5401	PFAM Sporulation and spore germination
DUY81_RS10520	COG5002	protein histidine kinase activity
DUY81_RS10525	COG0745	RESPONSE REGULATOR receiver
DUY81_RS10530	COG1678	Uncharacterized ACR, COG1678
DUY81_RS10545	COG0165	Argininosuccinate lyase
DUY81_RS10550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DUY81_RS10560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DUY81_RS10570	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DUY81_RS10575	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DUY81_RS10580	COG2177	Part of the ABC transporter FtsEX involved in
DUY81_RS10585	COG2884	Cell division ATP-binding protein ftsE
DUY81_RS10590	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DUY81_RS10605	COG3152	Membrane
DUY81_RS10620	COG1674	ftsk spoiiie
DUY81_RS10640	COG1181	Belongs to the D-alanine--D-alanine ligase family
DUY81_RS10650	COG0066	3-isopropylmalate dehydratase activity
DUY81_RS10655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DUY81_RS10660	COG1414	Transcriptional regulator
DUY81_RS10680	COG0179	Fumarylacetoacetate (FAA) hydrolase
DUY81_RS10690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DUY81_RS10695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DUY81_RS10700	COG0473	3-isopropylmalate dehydrogenase activity
DUY81_RS10720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DUY81_RS10725	COG0440	acetolactate synthase activity
DUY81_RS10735	COG0537	adenosine 5'-monophosphoramidase activity
DUY81_RS10740	COG0107	imidazoleglycerol-phosphate synthase activity
DUY81_RS10760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DUY81_RS10780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DUY81_RS10815	COG0504	CTP synthase activity
DUY81_RS10820	COG0497	DNA recombination
DUY81_RS10825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DUY81_RS10840	COG1122	ATPase activity
DUY81_RS10845	COG1268	BioY protein
DUY81_RS10850	COG0647	UMP catabolic process
DUY81_RS10880	COG0667	Aldo Keto reductase
DUY81_RS10885	COG4716	Myosin-crossreactive antigen
DUY81_RS10895	COG1381	Involved in DNA repair and RecF pathway recombination
DUY81_RS10910	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DUY81_RS10920	COG0765	amino acid transport
DUY81_RS10925	COG0765	amino acid transport
DUY81_RS10930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DUY81_RS10935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DUY81_RS10945	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DUY81_RS10955	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DUY81_RS10975	COG2226	methyltransferase
DUY81_RS10990	COG0596	Alpha beta hydrolase
DUY81_RS11015	COG4152	abc transporter atp-binding protein
DUY81_RS11020	COG2197	response regulator
DUY81_RS11030	COG0343	queuine tRNA-ribosyltransferase activity
DUY81_RS11035	COG5006	permease, DMT superfamily
DUY81_RS11040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DUY81_RS11055	COG2213	PTS system mannitol-specific
DUY81_RS11055	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DUY81_RS11060	COG1063	alcohol dehydrogenase
DUY81_RS11070	COG0484	heat shock protein binding
DUY81_RS11075	COG1420	regulation of RNA biosynthetic process
DUY81_RS11095	COG0483	inositol monophosphate 1-phosphatase activity
DUY81_RS11115	COG1175	transmembrane transport
DUY81_RS11120	COG0395	ABC-type sugar transport system, permease component
DUY81_RS11130	COG0477	Major facilitator Superfamily
DUY81_RS11135	COG1309	transcriptional regulator
DUY81_RS11140	COG1131	(ABC) transporter
DUY81_RS11150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DUY81_RS11155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DUY81_RS11165	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DUY81_RS11175	COG1169	isochorismate synthase
DUY81_RS11180	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DUY81_RS11185	COG4948	Mandelate Racemase Muconate Lactonizing
DUY81_RS11205	COG0481	GTPase activity
DUY81_RS11220	COG0268	Binds directly to 16S ribosomal RNA
DUY81_RS11230	COG1061	Type III restriction enzyme res subunit
DUY81_RS11235	COG0658	competence protein
DUY81_RS11235	COG2333	competence protein COMEC
DUY81_RS11245	COG0495	leucyl-tRNA aminoacylation
DUY81_RS11260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DUY81_RS11265	COG1063	alcohol dehydrogenase
DUY81_RS11270	COG0590	tRNA wobble adenosine to inosine editing
DUY81_RS11340	COG0488	(ABC) transporter
DUY81_RS11375	COG1522	sequence-specific DNA binding
DUY81_RS11380	COG1280	lysine exporter protein (LysE YggA)
DUY81_RS11435	COG2801	Transposase and inactivated derivatives
DUY81_RS11440	COG2130	NADP-dependent
DUY81_RS11450	COG1309	transcriptional regulator
DUY81_RS11515	COG4974	Belongs to the 'phage' integrase family
DUY81_RS11540	COG0732	type I restriction modification DNA specificity domain
DUY81_RS11605	COG0741	lytic transglycosylase activity
DUY81_RS11605	COG0739	heme binding
DUY81_RS11605	COG1196	nuclear chromosome segregation
DUY81_RS11730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DUY81_RS11735	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DUY81_RS11740	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DUY81_RS11745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DUY81_RS11760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DUY81_RS11765	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DUY81_RS11770	COG1530	ribonuclease E activity
DUY81_RS11780	COG1472	Belongs to the glycosyl hydrolase 3 family
DUY81_RS11790	COG0105	UTP biosynthetic process
DUY81_RS11800	COG0285	dihydrofolate synthase activity
DUY81_RS11810	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DUY81_RS11815	COG0149	triose-phosphate isomerase activity
DUY81_RS11820	COG0126	phosphoglycerate kinase activity
DUY81_RS11825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DUY81_RS11830	COG1481	regulation of sporulation
DUY81_RS11840	COG1660	Displays ATPase and GTPase activities
DUY81_RS11845	COG0322	excinuclease ABC activity
DUY81_RS11865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DUY81_RS11880	COG0556	nucleotide-excision repair
DUY81_RS11890	COG0237	dephospho-CoA kinase activity
DUY81_RS11895	COG0539	negative regulation of cytoplasmic translation
DUY81_RS11920	COG2050	protein possibly involved in aromatic compounds catabolism
DUY81_RS11935	COG0469	pyruvate kinase activity
DUY81_RS11965	COG1799	cell septum assembly
DUY81_RS11975	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DUY81_RS11985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DUY81_RS11990	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DUY81_RS11995	COG0772	Belongs to the SEDS family
DUY81_RS12000	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DUY81_RS12005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DUY81_RS12010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DUY81_RS12020	COG0768	penicillin binding
DUY81_RS12030	COG0275	rRNA processing
DUY81_RS12035	COG2001	Belongs to the MraZ family
DUY81_RS12040	COG0714	Associated with various cellular activities
DUY81_RS12060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DUY81_RS12065	COG0509	glycine decarboxylation via glycine cleavage system
DUY81_RS12070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DUY81_RS12070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DUY81_RS12075	COG1131	(ABC) transporter
DUY81_RS12095	COG3265	gluconokinase activity
DUY81_RS12105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DUY81_RS12115	COG0596	Alpha beta hydrolase
DUY81_RS12120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DUY81_RS12120	COG1116	anion transmembrane transporter activity
DUY81_RS12140	COG0210	DNA helicase
DUY81_RS12145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DUY81_RS12150	COG0142	geranyltranstransferase activity
DUY81_RS12155	COG0352	thiamine-phosphate diphosphorylase activity
DUY81_RS12165	COG2815	serine threonine protein kinase
DUY81_RS12165	COG0515	serine threonine protein kinase
DUY81_RS12180	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DUY81_RS12185	COG2197	response regulator
DUY81_RS12205	COG1940	carbohydrate kinase activity
DUY81_RS12250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DUY81_RS12260	COG1845	cytochrome c oxidase, subunit III
DUY81_RS12265	COG2010	Cytochrome c
DUY81_RS12270	COG0723	plastoquinol--plastocyanin reductase activity
DUY81_RS12275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DUY81_RS12295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DUY81_RS12300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DUY81_RS12340	COG0508	dehydrogenase complex catalyzes the overall conversion of
DUY81_RS12345	COG0321	lipoyl(octanoyl) transferase activity
DUY81_RS12360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DUY81_RS12370	COG0488	(ABC) transporter
DUY81_RS12375	COG2239	Acts as a magnesium transporter
DUY81_RS12380	COG0586	Pfam SNARE associated Golgi protein
DUY81_RS12400	COG0174	glutamine synthetase
DUY81_RS12410	COG3093	addiction module antidote protein HigA
DUY81_RS12425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DUY81_RS12435	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DUY81_RS12460	COG0598	Magnesium transport protein CorA
DUY81_RS12480	COG0531	amino acid
DUY81_RS12485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DUY81_RS12500	COG0006	proline dipeptidase activity
DUY81_RS12535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DUY81_RS12540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DUY81_RS12565	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DUY81_RS12570	COG0297	glycogen (starch) synthase activity
DUY81_RS12585	COG1611	Belongs to the LOG family
DUY81_RS12595	COG2171	N-acyltransferase activity
DUY81_RS12620	COG2720	vancomycin resistance protein
DUY81_RS12625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DUY81_RS12630	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DUY81_RS12635	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DUY81_RS12640	COG2814	Major facilitator Superfamily
DUY81_RS12675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DUY81_RS12685	COG0647	UMP catabolic process
DUY81_RS12695	COG0698	ribose 5-phosphate isomerase
DUY81_RS12700	COG1349	DNA-binding transcription factor activity
DUY81_RS12705	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DUY81_RS12710	COG2376	Dihydroxyacetone kinase
DUY81_RS12715	COG1063	alcohol dehydrogenase
DUY81_RS12720	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_RS12740	COG1121	(ABC) transporter
DUY81_RS12745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DUY81_RS12775	COG0765	amino acid transport
DUY81_RS12780	COG1126	abc transporter atp-binding protein
DUY81_RS12795	COG2501	S4 domain
DUY81_RS12830	COG0833	amino acid
DUY81_RS12845	COG2133	pyrroloquinoline quinone binding
DUY81_RS12850	COG2716	regulation of RNA biosynthetic process
DUY81_RS12875	COG0477	Major facilitator Superfamily
DUY81_RS12880	COG0477	Major facilitator Superfamily
DUY81_RS12885	COG1028	Short-chain dehydrogenase reductase Sdr
DUY81_RS12885	COG3321	synthase
DUY81_RS12885	COG0604	alcohol dehydrogenase
DUY81_RS12910	COG1335	isochorismatase
DUY81_RS12915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DUY81_RS12935	COG0406	alpha-ribazole phosphatase activity
DUY81_RS12940	COG1132	(ABC) transporter
DUY81_RS12955	COG1397	ADP-ribosylglycohydrolase
DUY81_RS13020	COG3328	transposase activity
DUY81_RS13045	COG0012	GTP binding
DUY81_RS13065	COG1362	aminopeptidase activity
DUY81_RS13070	COG1322	Protein conserved in bacteria
DUY81_RS13075	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DUY81_RS13080	COG1570	exodeoxyribonuclease VII activity
DUY81_RS13085	COG1722	exodeoxyribonuclease VII activity
DUY81_RS13095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DUY81_RS13105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DUY81_RS13110	COG1331	Highly conserved protein containing a thioredoxin domain
DUY81_RS13125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DUY81_RS13140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DUY81_RS13145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DUY81_RS13200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DUY81_RS13205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DUY81_RS13205	COG0072	phenylalanine-tRNA ligase activity
DUY81_RS13210	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DUY81_RS13220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DUY81_RS13225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DUY81_RS13230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DUY81_RS13235	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DUY81_RS13290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DUY81_RS13295	COG2837	iron assimilation
DUY81_RS13325	COG0148	phosphopyruvate hydratase activity
DUY81_RS13345	COG0193	aminoacyl-tRNA hydrolase activity
DUY81_RS13350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DUY81_RS13355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DUY81_RS13360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DUY81_RS13370	COG1309	transcriptional regulator
DUY81_RS13375	COG1846	Transcriptional regulator
DUY81_RS13380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DUY81_RS13385	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DUY81_RS13390	COG0084	hydrolase, TatD family'
DUY81_RS13405	COG2233	PERMEase
DUY81_RS13415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DUY81_RS13420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DUY81_RS13445	COG0657	acetylesterase activity
DUY81_RS13475	COG0693	protein deglycase activity
DUY81_RS13485	COG0789	Transcriptional regulator
DUY81_RS13515	COG1053	succinate dehydrogenase
DUY81_RS13540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DUY81_RS13555	COG0436	Aminotransferase
DUY81_RS13610	COG2409	Drug exporters of the RND superfamily
DUY81_RS13660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DUY81_RS13675	COG1970	mechanosensitive ion channel activity
DUY81_RS13695	COG0673	inositol 2-dehydrogenase activity
DUY81_RS13700	COG2814	Major facilitator Superfamily
DUY81_RS13705	COG0673	inositol 2-dehydrogenase activity
DUY81_RS13720	COG3962	Belongs to the TPP enzyme family
DUY81_RS13725	COG3718	enzyme involved in inositol metabolism
DUY81_RS13735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DUY81_RS13740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DUY81_RS13745	COG3118	belongs to the thioredoxin family
DUY81_RS13750	COG2226	methyltransferase
DUY81_RS13755	COG1321	iron dependent repressor
DUY81_RS13780	COG2252	PERMEase
DUY81_RS13795	COG1278	Cold shock
DUY81_RS13800	COG0363	glucosamine-6-phosphate deaminase activity
DUY81_RS14040	COG0740	serine-type endopeptidase activity
DUY81_RS14160	COG1482	cell wall glycoprotein biosynthetic process
DUY81_RS14165	COG1854	S-ribosylhomocysteine lyase activity
DUY81_RS14195	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DUY81_RS14205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DUY81_RS14205	COG1648	precorrin-2 dehydrogenase activity
DUY81_RS14210	COG1797	cobyrinic acid a,c-diamide synthase activity
DUY81_RS14215	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DUY81_RS14240	COG0310	cobalt ion transport
DUY81_RS14255	COG1648	precorrin-2 dehydrogenase activity
DUY81_RS14255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DUY81_RS14275	COG1492	cobalamin metabolic process
DUY81_RS14280	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DUY81_RS14290	COG4585	Histidine kinase
DUY81_RS14310	COG0406	alpha-ribazole phosphatase activity
DUY81_RS14320	COG2197	response regulator
DUY81_RS14325	COG4585	Histidine kinase
DUY81_RS14335	COG1131	(ABC) transporter
DUY81_RS14340	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DUY81_RS14350	COG0156	8-amino-7-oxononanoate synthase activity
DUY81_RS14355	COG1063	alcohol dehydrogenase
DUY81_RS14360	COG0395	ABC-type sugar transport system, permease component
DUY81_RS14370	COG1653	transport
DUY81_RS14375	COG1940	carbohydrate kinase activity
DUY81_RS14380	COG1760	l-serine dehydratase
DUY81_RS14390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DUY81_RS14405	COG3842	ATPase activity
DUY81_RS14415	COG1484	DNA-dependent DNA replication
DUY81_RS14460	COG0626	cystathionine gamma-synthase activity
DUY81_RS14475	COG0215	cysteine-tRNA ligase activity
DUY81_RS14480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DUY81_RS14490	COG2814	Major facilitator Superfamily
DUY81_RS14495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DUY81_RS14515	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DUY81_RS14520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DUY81_RS14535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DUY81_RS14545	COG3775	system Galactitol-specific IIC component
DUY81_RS14555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DUY81_RS14560	COG1329	Transcriptional regulator
DUY81_RS14575	COG5002	protein histidine kinase activity
DUY81_RS14580	COG0704	Plays a role in the regulation of phosphate uptake
DUY81_RS14585	COG0588	phosphoglycerate mutase activity
DUY81_RS14590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DUY81_RS14595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DUY81_RS14625	COG0191	fructose-bisphosphate aldolase activity
DUY81_RS14640	COG0586	Pfam SNARE associated Golgi protein
DUY81_RS14660	COG0489	protein tyrosine kinase activity
DUY81_RS14665	COG2244	polysaccharide biosynthetic process
DUY81_RS14695	COG0438	transferase activity, transferring glycosyl groups
DUY81_RS14715	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DUY81_RS14715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DUY81_RS14720	COG1704	LemA family
DUY81_RS14740	COG0436	Aminotransferase
DUY81_RS14745	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_RS14755	COG1174	glycine betaine transport
DUY81_RS14765	COG1174	glycine betaine transport
DUY81_RS14785	COG4176	ABC-type proline glycine betaine transport system permease component
DUY81_RS14790	COG4175	Glycine betaine
DUY81_RS14790	COG0517	IMP dehydrogenase activity
DUY81_RS14820	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DUY81_RS14830	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DUY81_RS14835	COG1609	Transcriptional regulator
DUY81_RS14840	COG2182	Extracellular solute-binding protein
DUY81_RS14845	COG1175	transmembrane transport
DUY81_RS14850	COG0395	ABC-type sugar transport system, permease component
DUY81_RS14865	COG0702	epimerase
DUY81_RS14870	COG1309	transcriptional regulator
DUY81_RS14880	COG1511	domain protein
DUY81_RS14895	COG1486	melibiose metabolic process
DUY81_RS14905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DUY81_RS14915	COG1175	transmembrane transport
DUY81_RS14920	COG0395	ABC-type sugar transport system, permease component
DUY81_RS14925	COG0542	response to heat
DUY81_RS14935	COG0395	ABC-type sugar transport system, permease component
DUY81_RS14950	COG2211	Major facilitator Superfamily
DUY81_RS14950	COG2190	(PTS) system
DUY81_RS14960	COG1609	Transcriptional regulator
DUY81_RS14965	COG3588	fructose-bisphosphate aldolase
DUY81_RS14980	COG4585	Histidine kinase
DUY81_RS14985	COG2197	response regulator
DUY81_RS14995	COG1136	(ABC) transporter
DUY81_RS14995	COG4591	ABC-type transport system involved in lipoprotein release permease component
DUY81_RS15000	COG0577	efflux transmembrane transporter activity
DUY81_RS15000	COG1136	(ABC) transporter
DUY81_RS15010	COG1113	amino acid transport
DUY81_RS15015	COG2985	domain, Protein
DUY81_RS15015	COG0569	domain protein
DUY81_RS15020	COG3527	Alpha-acetolactate decarboxylase
DUY81_RS15025	COG1063	alcohol dehydrogenase
DUY81_RS15030	COG0789	Transcriptional regulator
DUY81_RS15035	COG0484	heat shock protein binding
DUY81_RS15040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DUY81_RS15060	COG0745	RESPONSE REGULATOR receiver
DUY81_RS15065	COG2205	protein histidine kinase activity
DUY81_RS15070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DUY81_RS15085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DUY81_RS15085	COG0574	Belongs to the PEP-utilizing enzyme family
DUY81_RS15090	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DUY81_RS15095	COG2813	Specifically methylates the guanine in position
DUY81_RS15100	COG3830	Belongs to the UPF0237 family
DUY81_RS15100	COG0560	Phosphoserine phosphatase
DUY81_RS15105	COG0676	glucose-6-phosphate 1-epimerase activity
DUY81_RS15120	COG1309	transcriptional regulator
DUY81_RS15125	COG1131	(ABC) transporter
DUY81_RS15140	COG2814	Major facilitator Superfamily
DUY81_RS15145	COG4608	Belongs to the ABC transporter superfamily
DUY81_RS15150	COG0154	amidase activity
DUY81_RS15195	COG1027	Aspartate ammonia-lyase
DUY81_RS15210	COG0601	transmembrane transport
DUY81_RS15225	COG0673	inositol 2-dehydrogenase activity
DUY81_RS15235	COG1609	Transcriptional regulator
DUY81_RS15240	COG1609	Transcriptional regulator
DUY81_RS15280	COG1609	Transcriptional regulator
DUY81_RS15285	COG3254	rhamnose metabolic process
DUY81_RS15290	COG2814	Major facilitator Superfamily
DUY81_RS15295	COG4952	isomerase
DUY81_RS15300	COG1070	Carbohydrate kinase
DUY81_RS15310	COG1012	belongs to the aldehyde dehydrogenase family
DUY81_RS15325	COG2814	Major facilitator Superfamily
DUY81_RS15345	COG0018	arginyl-trna synthetase
DUY81_RS15350	COG0656	L-ascorbic acid biosynthetic process
DUY81_RS15355	COG2814	Major facilitator Superfamily
DUY81_RS15370	COG0166	Belongs to the GPI family
DUY81_RS15380	COG4581	dead DEAH box helicase
DUY81_RS15390	COG1881	PFAM PEBP family protein
DUY81_RS15410	COG0667	Aldo Keto reductase
DUY81_RS15420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DUY81_RS15425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DUY81_RS15445	COG0583	DNA-binding transcription factor activity
DUY81_RS15450	COG2814	Major facilitator Superfamily
DUY81_RS15490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DUY81_RS15495	COG0561	phosphatase activity
DUY81_RS15500	COG0561	phosphatase activity
DUY81_RS15515	COG0577	efflux transmembrane transporter activity
DUY81_RS15515	COG1136	(ABC) transporter
DUY81_RS15540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DUY81_RS15545	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DUY81_RS15590	COG1131	(ABC) transporter
DUY81_RS15595	COG1309	transcriptional regulator
DUY81_RS15600	COG1113	amino acid transport
DUY81_RS15610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DUY81_RS15615	COG1695	Transcriptional regulator
DUY81_RS15620	COG0477	Major facilitator Superfamily
DUY81_RS15670	COG1484	DNA-dependent DNA replication
DUY81_RS15695	COG0438	transferase activity, transferring glycosyl groups
DUY81_RS15705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DUY81_RS15710	COG0489	protein tyrosine kinase activity
DUY81_RS15720	COG1316	TRANSCRIPTIONal
DUY81_RS15740	COG0604	alcohol dehydrogenase
DUY81_RS15745	COG3408	Glycogen debranching enzyme
DUY81_RS15755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DUY81_RS15760	COG1088	dTDP-glucose 4,6-dehydratase activity
DUY81_RS15770	COG1716	ATPase activity
DUY81_RS15775	COG1716	ATPase activity
DUY81_RS15790	COG0768	penicillin binding
DUY81_RS15795	COG0515	serine threonine protein kinase
DUY81_RS15815	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DUY81_RS15820	COG0393	Putative heavy-metal-binding
DUY81_RS15830	COG1953	Uracil, thiamine, allantoin
DUY81_RS15835	COG1301	dicarboxylic acid transport
DUY81_RS15840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DUY81_RS15845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DUY81_RS15865	COG2186	Transcriptional regulator
DUY81_RS15870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DUY81_RS15875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DUY81_RS15900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DUY81_RS15905	COG1309	transcriptional regulator
DUY81_RS15920	COG1609	Transcriptional regulator
DUY81_RS15930	COG0395	ABC-type sugar transport system, permease component
DUY81_RS15935	COG1653	transport
DUY81_RS15945	COG1454	alcohol dehydrogenase
DUY81_RS15950	COG2814	Major facilitator Superfamily
DUY81_RS15980	COG1271	oxidase subunit
DUY81_RS15985	COG1294	oxidase, subunit
DUY81_RS15990	COG4988	ABC transporter
DUY81_RS15995	COG1132	(ABC) transporter
DUY81_RS16005	COG1556	Lactate utilization protein
DUY81_RS16010	COG1139	Iron-sulfur cluster binding protein
DUY81_RS16015	COG0247	lactate metabolic process
DUY81_RS16020	COG1620	l-lactate permease
DUY81_RS16025	COG2186	Transcriptional regulator
DUY81_RS16040	COG0674	pyruvate-flavodoxin oxidoreductase activity
DUY81_RS16040	COG1013	pyruvate-flavodoxin oxidoreductase activity
DUY81_RS16040	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DUY81_RS16040	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DUY81_RS16045	COG0167	dihydroorotate dehydrogenase activity
DUY81_RS16055	COG1083	cytidylyl-transferase
DUY81_RS16060	COG2089	acid synthase
DUY81_RS16090	COG0438	transferase activity, transferring glycosyl groups
DUY81_RS16115	COG0489	protein tyrosine kinase activity
DUY81_RS16165	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DUY81_RS16180	COG1937	Protein conserved in bacteria
DUY81_RS16185	COG0305	Participates in initiation and elongation during chromosome replication
DUY81_RS16190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DUY81_RS16190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DUY81_RS16195	COG3118	belongs to the thioredoxin family
DUY81_RS16200	COG0492	ferredoxin-NADP+ reductase activity
DUY81_RS16205	COG0386	Belongs to the glutathione peroxidase family
DUY81_RS16210	COG1846	Transcriptional regulator
DUY81_RS16230	COG2094	Belongs to the DNA glycosylase MPG family
DUY81_RS16245	COG1643	Atp-dependent helicase
DUY81_RS16260	COG2897	thiosulfate sulfurtransferase activity
DUY81_RS16300	COG0297	glycogen (starch) synthase activity
DUY81_RS16310	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DUY81_RS16315	COG1126	abc transporter atp-binding protein
DUY81_RS16320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DUY81_RS16325	COG0765	amino acid transport
DUY81_RS16330	COG0765	amino acid transport
DUY81_RS16340	COG1105	Belongs to the carbohydrate kinase PfkB family
DUY81_RS16345	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DUY81_RS16345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DUY81_RS16345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DUY81_RS16375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DUY81_RS16410	COG0438	transferase activity, transferring glycosyl groups
DUY81_RS16415	COG0438	transferase activity, transferring glycosyl groups
DUY81_RS16475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DUY81_RS16500	COG2072	flavoprotein involved in K transport
DUY81_RS16525	COG1253	flavin adenine dinucleotide binding
DUY81_RS16555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DUY81_RS16570	COG1063	alcohol dehydrogenase
DUY81_RS16575	COG0586	Pfam SNARE associated Golgi protein
DUY81_RS16585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DUY81_RS16595	COG1119	ATPase activity
DUY81_RS16615	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DUY81_RS16620	COG1609	Transcriptional regulator
DUY81_RS16625	COG0673	inositol 2-dehydrogenase activity
DUY81_RS16635	COG2186	Transcriptional regulator
DUY81_RS16645	COG5564	TIM-barrel signal transduction protein
DUY81_RS16675	COG2211	Major facilitator Superfamily