locus-tag	class	description
FEZ32_RS00020	COG1280	lysine exporter protein (LysE YggA)
FEZ32_RS00035	COG2050	protein possibly involved in aromatic compounds catabolism
FEZ32_RS00050	COG0469	pyruvate kinase activity
FEZ32_RS00080	COG1799	cell septum assembly
FEZ32_RS00085	COG1496	oxidoreductase activity
FEZ32_RS00090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FEZ32_RS00100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FEZ32_RS00105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FEZ32_RS00115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FEZ32_RS00120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FEZ32_RS00125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FEZ32_RS00135	COG0768	penicillin binding
FEZ32_RS00145	COG0275	rRNA processing
FEZ32_RS00150	COG2001	Belongs to the MraZ family
FEZ32_RS00155	COG0714	Associated with various cellular activities
FEZ32_RS00180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FEZ32_RS00185	COG0509	glycine decarboxylation via glycine cleavage system
FEZ32_RS00190	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FEZ32_RS00190	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FEZ32_RS00200	COG1131	(ABC) transporter
FEZ32_RS00215	COG3265	gluconokinase activity
FEZ32_RS00230	COG1116	anion transmembrane transporter activity
FEZ32_RS00250	COG0210	DNA helicase
FEZ32_RS00265	COG0142	geranyltranstransferase activity
FEZ32_RS00275	COG0515	serine threonine protein kinase
FEZ32_RS00275	COG2815	serine threonine protein kinase
FEZ32_RS00290	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FEZ32_RS00295	COG2197	response regulator
FEZ32_RS00320	COG1940	carbohydrate kinase activity
FEZ32_RS00325	COG0791	NLP P60 protein
FEZ32_RS00325	COG3883	PFAM NLP P60 protein
FEZ32_RS00365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FEZ32_RS00375	COG1845	cytochrome c oxidase, subunit III
FEZ32_RS00380	COG2010	Cytochrome c
FEZ32_RS00385	COG0723	plastoquinol--plastocyanin reductase activity
FEZ32_RS00390	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FEZ32_RS00415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FEZ32_RS00420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FEZ32_RS00460	COG0508	dehydrogenase complex catalyzes the overall conversion of
FEZ32_RS00465	COG0321	lipoyl(octanoyl) transferase activity
FEZ32_RS00480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FEZ32_RS00490	COG0488	(ABC) transporter
FEZ32_RS00500	COG0438	transferase activity, transferring glycosyl groups
FEZ32_RS00515	COG0174	glutamine synthetase
FEZ32_RS00575	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FEZ32_RS00575	COG3323	Protein of unknown function (DUF1653)
FEZ32_RS00580	COG2966	Psort location CytoplasmicMembrane, score
FEZ32_RS00585	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FEZ32_RS00595	COG0174	glutamine synthetase
FEZ32_RS00605	COG0577	efflux transmembrane transporter activity
FEZ32_RS00605	COG1136	(ABC) transporter
FEZ32_RS00610	COG0577	efflux transmembrane transporter activity
FEZ32_RS00610	COG1136	(ABC) transporter
FEZ32_RS00655	COG3328	transposase activity
FEZ32_RS00695	COG0598	Magnesium transport protein CorA
FEZ32_RS00715	COG0531	amino acid
FEZ32_RS00720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FEZ32_RS00730	COG0006	proline dipeptidase activity
FEZ32_RS00760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FEZ32_RS00765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FEZ32_RS00780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FEZ32_RS00785	COG0297	glycogen (starch) synthase activity
FEZ32_RS00800	COG1611	Belongs to the LOG family
FEZ32_RS00805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEZ32_RS00840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FEZ32_RS00845	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FEZ32_RS00850	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FEZ32_RS00855	COG2814	Major facilitator Superfamily
FEZ32_RS00885	COG0371	Dehydrogenase
FEZ32_RS00895	COG0647	UMP catabolic process
FEZ32_RS00905	COG0698	ribose 5-phosphate isomerase
FEZ32_RS00910	COG1349	DNA-binding transcription factor activity
FEZ32_RS00920	COG2376	Dihydroxyacetone kinase
FEZ32_RS00925	COG1063	alcohol dehydrogenase
FEZ32_RS00930	COG1012	belongs to the aldehyde dehydrogenase family
FEZ32_RS00950	COG1121	(ABC) transporter
FEZ32_RS00955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FEZ32_RS00980	COG0765	amino acid transport
FEZ32_RS00990	COG2501	S4 domain
FEZ32_RS01025	COG0667	Aldo Keto reductase
FEZ32_RS01030	COG2133	pyrroloquinoline quinone binding
FEZ32_RS01065	COG0477	Major facilitator Superfamily
FEZ32_RS01085	COG1335	isochorismatase
FEZ32_RS01090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FEZ32_RS01100	COG1132	(ABC) transporter
FEZ32_RS01115	COG4115	mRNA cleavage
FEZ32_RS01120	COG2161	toxin-antitoxin pair type II binding
FEZ32_RS01130	COG0012	GTP binding
FEZ32_RS01140	COG1362	aminopeptidase activity
FEZ32_RS01145	COG1322	Protein conserved in bacteria
FEZ32_RS01150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FEZ32_RS01155	COG1570	exodeoxyribonuclease VII activity
FEZ32_RS01160	COG1722	exodeoxyribonuclease VII activity
FEZ32_RS01170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FEZ32_RS01180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FEZ32_RS01185	COG1331	Highly conserved protein containing a thioredoxin domain
FEZ32_RS01200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FEZ32_RS01215	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FEZ32_RS01220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FEZ32_RS01255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FEZ32_RS01260	COG1438	arginine binding
FEZ32_RS01270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FEZ32_RS01275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEZ32_RS01275	COG0072	phenylalanine-tRNA ligase activity
FEZ32_RS01280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FEZ32_RS01290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FEZ32_RS01295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FEZ32_RS01300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FEZ32_RS01305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FEZ32_RS01330	COG0494	nUDIX hydrolase
FEZ32_RS01375	COG0148	phosphopyruvate hydratase activity
FEZ32_RS01395	COG0193	aminoacyl-tRNA hydrolase activity
FEZ32_RS01400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FEZ32_RS01405	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FEZ32_RS01410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FEZ32_RS01425	COG1846	Transcriptional regulator
FEZ32_RS01430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FEZ32_RS01435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FEZ32_RS01440	COG0084	hydrolase, TatD family'
FEZ32_RS01455	COG2233	PERMEase
FEZ32_RS01460	COG0515	serine threonine protein kinase
FEZ32_RS01465	COG1984	allophanate hydrolase subunit 2
FEZ32_RS01470	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FEZ32_RS01490	COG0657	acetylesterase activity
FEZ32_RS01500	COG0477	Major facilitator Superfamily
FEZ32_RS01545	COG0673	inositol 2-dehydrogenase activity
FEZ32_RS01560	COG0640	Transcriptional regulator
FEZ32_RS01575	COG0628	permease
FEZ32_RS01615	COG1970	mechanosensitive ion channel activity
FEZ32_RS01635	COG0673	inositol 2-dehydrogenase activity
FEZ32_RS01640	COG2814	Major facilitator Superfamily
FEZ32_RS01660	COG3962	Belongs to the TPP enzyme family
FEZ32_RS01665	COG3718	enzyme involved in inositol metabolism
FEZ32_RS01675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FEZ32_RS01680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FEZ32_RS01685	COG3118	belongs to the thioredoxin family
FEZ32_RS01690	COG2226	methyltransferase
FEZ32_RS01695	COG1321	iron dependent repressor
FEZ32_RS01705	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FEZ32_RS01720	COG2252	PERMEase
FEZ32_RS01735	COG1278	Cold shock
FEZ32_RS01740	COG0390	transport system, permease component
FEZ32_RS01745	COG0363	glucosamine-6-phosphate deaminase activity
FEZ32_RS01775	COG1609	Transcriptional regulator
FEZ32_RS01795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FEZ32_RS01795	COG1648	precorrin-2 dehydrogenase activity
FEZ32_RS01815	COG1492	cobalamin metabolic process
FEZ32_RS01820	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FEZ32_RS01845	COG3189	MarR family transcriptional regulator
FEZ32_RS01850	COG0156	8-amino-7-oxononanoate synthase activity
FEZ32_RS01855	COG1063	alcohol dehydrogenase
FEZ32_RS01860	COG0395	ABC-type sugar transport system, permease component
FEZ32_RS01865	COG1175	transmembrane transport
FEZ32_RS01870	COG1653	transport
FEZ32_RS01875	COG1940	carbohydrate kinase activity
FEZ32_RS01880	COG1760	l-serine dehydratase
FEZ32_RS01885	COG3415	Transposase
FEZ32_RS01885	COG2801	Transposase and inactivated derivatives
FEZ32_RS01895	COG3842	ATPase activity
FEZ32_RS01905	COG0626	cystathionine gamma-synthase activity
FEZ32_RS01920	COG0215	cysteine-tRNA ligase activity
FEZ32_RS01925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FEZ32_RS01930	COG2814	Major facilitator Superfamily
FEZ32_RS01935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FEZ32_RS01950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEZ32_RS01965	COG4948	Mandelate Racemase Muconate Lactonizing
FEZ32_RS01975	COG0534	Mate efflux family protein
FEZ32_RS01980	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FEZ32_RS01985	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FEZ32_RS01995	COG2390	Transcriptional regulator
FEZ32_RS02000	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FEZ32_RS02010	COG3775	system Galactitol-specific IIC component
FEZ32_RS02025	COG1329	Transcriptional regulator
FEZ32_RS02040	COG5002	protein histidine kinase activity
FEZ32_RS02050	COG0588	phosphoglycerate mutase activity
FEZ32_RS02055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEZ32_RS02060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FEZ32_RS02090	COG3739	integral membrane protein
FEZ32_RS02095	COG0191	fructose-bisphosphate aldolase activity
FEZ32_RS02110	COG0586	Pfam SNARE associated Golgi protein
FEZ32_RS02115	COG1704	LemA family
FEZ32_RS02135	COG4176	ABC-type proline glycine betaine transport system permease component
FEZ32_RS02140	COG0517	IMP dehydrogenase activity
FEZ32_RS02140	COG4175	Glycine betaine
FEZ32_RS02145	COG3012	SEC-C Motif Domain Protein
FEZ32_RS02160	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FEZ32_RS02170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FEZ32_RS02180	COG0076	glutamate decarboxylase activity
FEZ32_RS02185	COG3012	SEC-C Motif Domain Protein
FEZ32_RS02195	COG0542	response to heat
FEZ32_RS02205	COG0395	ABC-type sugar transport system, permease component
FEZ32_RS02220	COG3588	fructose-bisphosphate aldolase
FEZ32_RS02235	COG2197	response regulator
FEZ32_RS02245	COG4591	ABC-type transport system involved in lipoprotein release permease component
FEZ32_RS02245	COG1136	(ABC) transporter
FEZ32_RS02250	COG1136	(ABC) transporter
FEZ32_RS02250	COG0577	efflux transmembrane transporter activity
FEZ32_RS02255	COG1113	amino acid transport
FEZ32_RS02260	COG0569	domain protein
FEZ32_RS02260	COG2985	domain, Protein
FEZ32_RS02265	COG3527	Alpha-acetolactate decarboxylase
FEZ32_RS02275	COG0789	Transcriptional regulator
FEZ32_RS02280	COG0484	heat shock protein binding
FEZ32_RS02285	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FEZ32_RS02310	COG0745	RESPONSE REGULATOR receiver
FEZ32_RS02315	COG2205	protein histidine kinase activity
FEZ32_RS02320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FEZ32_RS02320	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FEZ32_RS02330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FEZ32_RS02340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FEZ32_RS02355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FEZ32_RS02355	COG0574	Belongs to the PEP-utilizing enzyme family
FEZ32_RS02360	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FEZ32_RS02365	COG2813	Specifically methylates the guanine in position
FEZ32_RS02370	COG3830	Belongs to the UPF0237 family
FEZ32_RS02370	COG0560	Phosphoserine phosphatase
FEZ32_RS02375	COG0676	glucose-6-phosphate 1-epimerase activity
FEZ32_RS02410	COG4608	Belongs to the ABC transporter superfamily
FEZ32_RS02415	COG0154	amidase activity
FEZ32_RS02435	COG1609	Transcriptional regulator
FEZ32_RS02445	COG2188	Transcriptional regulator
FEZ32_RS02470	COG3959	Transketolase, thiamine diphosphate binding domain
FEZ32_RS02475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FEZ32_RS02490	COG0281	malic enzyme
FEZ32_RS02495	COG0673	inositol 2-dehydrogenase activity
FEZ32_RS02505	COG2814	Major facilitator Superfamily
FEZ32_RS02510	COG1082	Xylose isomerase domain protein TIM barrel
FEZ32_RS02515	COG0673	inositol 2-dehydrogenase activity
FEZ32_RS02520	COG3718	enzyme involved in inositol metabolism
FEZ32_RS02530	COG1414	Transcriptional regulator
FEZ32_RS02540	COG3428	Bacterial PH domain
FEZ32_RS02550	COG0018	arginyl-trna synthetase
FEZ32_RS02555	COG0656	L-ascorbic acid biosynthetic process
FEZ32_RS02560	COG2814	Major facilitator Superfamily
FEZ32_RS02565	COG2949	membrane
FEZ32_RS02570	COG0747	negative chemotaxis
FEZ32_RS02580	COG0601	transmembrane transport
FEZ32_RS02585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FEZ32_RS02590	COG0444	Belongs to the ABC transporter superfamily
FEZ32_RS02600	COG0166	Belongs to the GPI family
FEZ32_RS02615	COG4581	dead DEAH box helicase
FEZ32_RS02640	COG0667	Aldo Keto reductase
FEZ32_RS02645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FEZ32_RS02650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FEZ32_RS02665	COG2814	Major facilitator Superfamily
FEZ32_RS02695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FEZ32_RS02700	COG0561	phosphatase activity
FEZ32_RS02705	COG0561	phosphatase activity
FEZ32_RS02725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FEZ32_RS02730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FEZ32_RS02770	COG0477	Major facilitator Superfamily
FEZ32_RS02805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FEZ32_RS02815	COG0489	protein tyrosine kinase activity
FEZ32_RS02850	COG2244	polysaccharide biosynthetic process
FEZ32_RS02895	COG2801	Transposase and inactivated derivatives
FEZ32_RS02910	COG3328	transposase activity
FEZ32_RS02920	COG1045	serine acetyltransferase
FEZ32_RS02945	COG1316	TRANSCRIPTIONal
FEZ32_RS02995	COG0456	acetyltransferase
FEZ32_RS03030	COG0783	Belongs to the Dps family
FEZ32_RS03035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FEZ32_RS03045	COG2217	Heavy metal translocating P-type atpase
FEZ32_RS03055	COG3189	MarR family transcriptional regulator
FEZ32_RS03110	COG3408	Glycogen debranching enzyme
FEZ32_RS03130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FEZ32_RS03135	COG1088	dTDP-glucose 4,6-dehydratase activity
FEZ32_RS03145	COG1716	ATPase activity
FEZ32_RS03150	COG1716	ATPase activity
FEZ32_RS03165	COG0768	penicillin binding
FEZ32_RS03170	COG0515	serine threonine protein kinase
FEZ32_RS03195	COG3328	transposase activity
FEZ32_RS03205	COG3328	transposase activity
FEZ32_RS03215	COG1953	Uracil, thiamine, allantoin
FEZ32_RS03220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FEZ32_RS03225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FEZ32_RS03250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FEZ32_RS03255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FEZ32_RS03270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEZ32_RS03290	COG1454	alcohol dehydrogenase
FEZ32_RS03325	COG1271	oxidase subunit
FEZ32_RS03330	COG1294	oxidase, subunit
FEZ32_RS03335	COG4988	ABC transporter
FEZ32_RS03340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FEZ32_RS03345	COG1556	Lactate utilization protein
FEZ32_RS03350	COG1139	Iron-sulfur cluster binding protein
FEZ32_RS03355	COG0247	lactate metabolic process
FEZ32_RS03360	COG1620	l-lactate permease
FEZ32_RS03365	COG2186	Transcriptional regulator
FEZ32_RS03370	COG0493	'glutamate synthase
FEZ32_RS03370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FEZ32_RS03375	COG0674	pyruvate-flavodoxin oxidoreductase activity
FEZ32_RS03375	COG1013	pyruvate-flavodoxin oxidoreductase activity
FEZ32_RS03375	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FEZ32_RS03375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FEZ32_RS03380	COG0167	dihydroorotate dehydrogenase activity
FEZ32_RS03385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FEZ32_RS03395	COG2608	mercury ion transmembrane transporter activity
FEZ32_RS03400	COG1937	Protein conserved in bacteria
FEZ32_RS03405	COG0305	Participates in initiation and elongation during chromosome replication
FEZ32_RS03410	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FEZ32_RS03410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FEZ32_RS03430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FEZ32_RS03440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FEZ32_RS03455	COG3118	belongs to the thioredoxin family
FEZ32_RS03460	COG0492	ferredoxin-NADP+ reductase activity
FEZ32_RS03480	COG2094	Belongs to the DNA glycosylase MPG family
FEZ32_RS03490	COG1643	Atp-dependent helicase
FEZ32_RS03505	COG2897	thiosulfate sulfurtransferase activity
FEZ32_RS03535	COG0438	transferase activity, transferring glycosyl groups
FEZ32_RS03545	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FEZ32_RS03550	COG1126	abc transporter atp-binding protein
FEZ32_RS03555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FEZ32_RS03560	COG0765	amino acid transport
FEZ32_RS03565	COG0765	amino acid transport
FEZ32_RS03570	COG1105	Belongs to the carbohydrate kinase PfkB family
FEZ32_RS03600	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FEZ32_RS03630	COG3328	transposase activity
FEZ32_RS03645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FEZ32_RS03680	COG1660	Displays ATPase and GTPase activities
FEZ32_RS03690	COG0626	cystathionine gamma-synthase activity
FEZ32_RS03695	COG0387	Pfam Sodium calcium exchanger
FEZ32_RS03700	COG2124	cytochrome p450
FEZ32_RS03715	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FEZ32_RS03725	COG0142	geranyltranstransferase activity
FEZ32_RS03740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FEZ32_RS03760	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FEZ32_RS03765	COG2176	DNA-directed DNA polymerase activity
FEZ32_RS03765	COG5002	protein histidine kinase activity
FEZ32_RS03785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FEZ32_RS03795	COG2217	Heavy metal translocating P-type atpase
FEZ32_RS03805	COG2132	Multicopper oxidase
FEZ32_RS03810	COG2205	protein histidine kinase activity
FEZ32_RS03815	COG0745	RESPONSE REGULATOR receiver
FEZ32_RS03845	COG0686	Belongs to the AlaDH PNT family
FEZ32_RS03850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FEZ32_RS03860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FEZ32_RS03890	COG1201	RNA secondary structure unwinding
FEZ32_RS03900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FEZ32_RS03915	COG1401	restriction endodeoxyribonuclease activity
FEZ32_RS03925	COG1401	restriction endodeoxyribonuclease activity
FEZ32_RS03935	COG1268	BioY protein
FEZ32_RS03945	COG0183	Belongs to the thiolase family
FEZ32_RS03950	COG1486	melibiose metabolic process
FEZ32_RS03955	COG2326	polyphosphate kinase activity
FEZ32_RS03975	COG3386	PFAM SMP-30 Gluconolaconase
FEZ32_RS03985	COG0693	protein deglycase activity
FEZ32_RS03985	COG0753	catalase activity
FEZ32_RS04005	COG1028	Short-chain dehydrogenase reductase Sdr
FEZ32_RS04020	COG3328	transposase activity
FEZ32_RS04045	COG2261	transglycosylase associated protein
FEZ32_RS04050	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FEZ32_RS04055	COG0477	Major facilitator Superfamily
FEZ32_RS04075	COG2261	transglycosylase associated protein
FEZ32_RS04080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FEZ32_RS04085	COG0352	thiamine-phosphate diphosphorylase activity
FEZ32_RS04090	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FEZ32_RS04095	COG0477	Major facilitator Superfamily
FEZ32_RS04100	COG0352	thiamine-phosphate diphosphorylase activity
FEZ32_RS04100	COG0351	phosphomethylpyrimidine kinase
FEZ32_RS04100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FEZ32_RS04105	COG1968	undecaprenyl-diphosphatase activity
FEZ32_RS04110	COG0359	binds to the 23S rRNA
FEZ32_RS04115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FEZ32_RS04120	COG0629	single-stranded DNA binding
FEZ32_RS04125	COG0360	Binds together with S18 to 16S ribosomal RNA
FEZ32_RS04130	COG2837	iron assimilation
FEZ32_RS04135	COG2822	iron ion transport
FEZ32_RS04140	COG0672	)-iron permease
FEZ32_RS04160	COG0300	oxidoreductase activity
FEZ32_RS04200	COG0277	FAD linked oxidase domain protein
FEZ32_RS04210	COG2197	response regulator
FEZ32_RS04220	COG1131	(ABC) transporter
FEZ32_RS04230	COG4585	Histidine kinase
FEZ32_RS04235	COG0247	lactate metabolic process
FEZ32_RS04240	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
FEZ32_RS04245	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FEZ32_RS04250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FEZ32_RS04280	COG2801	Transposase and inactivated derivatives
FEZ32_RS04305	COG0534	Mate efflux family protein
FEZ32_RS04315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FEZ32_RS04335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FEZ32_RS04360	COG2391	methyltransferase activity
FEZ32_RS04365	COG0425	Belongs to the sulfur carrier protein TusA family
FEZ32_RS04370	COG0842	Transport permease protein
FEZ32_RS04370	COG1131	(ABC) transporter
FEZ32_RS04370	COG1716	ATPase activity
FEZ32_RS04375	COG0515	serine threonine protein kinase
FEZ32_RS04385	COG0205	6-phosphofructokinase activity
FEZ32_RS04390	COG2267	carboxylic ester hydrolase activity
FEZ32_RS04415	COG3842	ATPase activity
FEZ32_RS04420	COG2271	Major facilitator Superfamily
FEZ32_RS04435	COG1376	ErfK ybiS ycfS ynhG family protein
FEZ32_RS04440	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FEZ32_RS04470	COG2848	UPF0210 protein
FEZ32_RS04475	COG3830	Belongs to the UPF0237 family
FEZ32_RS04485	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FEZ32_RS04500	COG0668	transmembrane transport
FEZ32_RS04505	COG1929	Belongs to the glycerate kinase type-1 family
FEZ32_RS04510	COG0617	tRNA 3'-terminal CCA addition
FEZ32_RS04525	COG0515	serine threonine protein kinase
FEZ32_RS04525	COG2815	serine threonine protein kinase
FEZ32_RS04530	COG1595	DNA-templated transcription, initiation
FEZ32_RS04540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FEZ32_RS04545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FEZ32_RS04550	COG2390	Transcriptional regulator
FEZ32_RS04555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FEZ32_RS04570	COG0564	pseudouridine synthase activity
FEZ32_RS04600	COG2066	Belongs to the glutaminase family
FEZ32_RS04620	COG4585	Histidine kinase
FEZ32_RS04635	COG1082	Xylose isomerase domain protein TIM barrel
FEZ32_RS04640	COG2188	Transcriptional regulator
FEZ32_RS04650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEZ32_RS04655	COG1181	Belongs to the D-alanine--D-alanine ligase family
FEZ32_RS04665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FEZ32_RS04665	COG0519	Catalyzes the synthesis of GMP from XMP
FEZ32_RS04675	COG1475	DNA binding
FEZ32_RS04680	COG1192	Involved in chromosome partitioning
FEZ32_RS04685	COG0357	Ribosomal RNA small subunit methyltransferase G
FEZ32_RS04695	COG0706	membrane insertase activity
FEZ32_RS04705	COG0594	ribonuclease P activity
FEZ32_RS04710	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FEZ32_RS04715	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FEZ32_RS04720	COG1136	(ABC) transporter
FEZ32_RS04720	COG0577	efflux transmembrane transporter activity
FEZ32_RS04725	COG0577	efflux transmembrane transporter activity
FEZ32_RS04730	COG0592	DNA-directed DNA polymerase activity
FEZ32_RS04740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FEZ32_RS04745	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FEZ32_RS04750	COG1482	cell wall glycoprotein biosynthetic process
FEZ32_RS04765	COG0187	DNA topoisomerase II activity
FEZ32_RS04770	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FEZ32_RS04775	COG3266	domain, Protein
FEZ32_RS04780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEZ32_RS04780	COG3711	transcriptional antiterminator
FEZ32_RS04790	COG2213	PTS system mannitol-specific
FEZ32_RS04795	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEZ32_RS04800	COG0246	Mannitol dehydrogenase
FEZ32_RS04805	COG0673	inositol 2-dehydrogenase activity
FEZ32_RS04810	COG0039	L-malate dehydrogenase activity
FEZ32_RS04830	COG0039	L-malate dehydrogenase activity
FEZ32_RS04845	COG0039	L-malate dehydrogenase activity
FEZ32_RS04855	COG0640	Transcriptional regulator
FEZ32_RS04870	COG2814	Major facilitator Superfamily
FEZ32_RS04880	COG2801	Transposase and inactivated derivatives
FEZ32_RS04920	COG2272	Belongs to the type-B carboxylesterase lipase family
FEZ32_RS04925	COG0436	Aminotransferase
FEZ32_RS04930	COG1942	4-Oxalocrotonate Tautomerase
FEZ32_RS04935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FEZ32_RS04945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEZ32_RS04955	COG3715	PTS system
FEZ32_RS04960	COG3716	PTS system mannose fructose sorbose family IID component
FEZ32_RS04985	COG1131	(ABC) transporter
FEZ32_RS04995	COG0095	Lipoate-protein ligase
FEZ32_RS05000	COG0765	amino acid transport
FEZ32_RS05005	COG1126	abc transporter atp-binding protein
FEZ32_RS05010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FEZ32_RS05045	COG0395	ABC-type sugar transport system, permease component
FEZ32_RS05055	COG0310	cobalt ion transport
FEZ32_RS05060	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
FEZ32_RS05065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FEZ32_RS05080	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FEZ32_RS05085	COG1797	cobyrinic acid a,c-diamide synthase activity
FEZ32_RS05090	COG1648	precorrin-2 dehydrogenase activity
FEZ32_RS05090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FEZ32_RS05100	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FEZ32_RS05130	COG1854	S-ribosylhomocysteine lyase activity
FEZ32_RS05170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FEZ32_RS05190	COG0540	Belongs to the ATCase OTCase family
FEZ32_RS05205	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FEZ32_RS05210	COG0114	fumarate hydratase activity
FEZ32_RS05275	COG1012	belongs to the aldehyde dehydrogenase family
FEZ32_RS05280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FEZ32_RS05290	COG3588	fructose-bisphosphate aldolase
FEZ32_RS05295	COG2197	response regulator
FEZ32_RS05300	COG4585	Histidine kinase
FEZ32_RS05310	COG1131	(ABC) transporter
FEZ32_RS05315	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FEZ32_RS05340	COG1136	(ABC) transporter
FEZ32_RS05340	COG0577	efflux transmembrane transporter activity
FEZ32_RS05345	COG2197	response regulator
FEZ32_RS05350	COG4585	Histidine kinase
FEZ32_RS05360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEZ32_RS05365	COG1309	transcriptional regulator
FEZ32_RS05370	COG2409	Drug exporters of the RND superfamily
FEZ32_RS05380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FEZ32_RS05385	COG0281	malic enzyme
FEZ32_RS05415	COG1254	Belongs to the acylphosphatase family
FEZ32_RS05425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FEZ32_RS05425	COG1042	CoA-binding domain protein
FEZ32_RS05425	COG0045	succinate-CoA ligase (ADP-forming) activity
FEZ32_RS05430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FEZ32_RS05440	COG1136	(ABC) transporter
FEZ32_RS05450	COG0205	6-phosphofructokinase activity
FEZ32_RS05480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FEZ32_RS05505	COG4948	Mandelate Racemase Muconate Lactonizing
FEZ32_RS05520	COG0435	Glutathione S-transferase
FEZ32_RS05530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FEZ32_RS05545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FEZ32_RS05550	COG0601	transmembrane transport
FEZ32_RS05575	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FEZ32_RS05585	COG2205	protein histidine kinase activity
FEZ32_RS05605	COG1132	(ABC) transporter
FEZ32_RS05610	COG1132	(ABC) transporter
FEZ32_RS05625	COG1175	transmembrane transport
FEZ32_RS05630	COG0395	ABC-type sugar transport system, permease component
FEZ32_RS05635	COG0366	Alpha amylase catalytic
FEZ32_RS05645	COG1285	pathogenesis
FEZ32_RS05650	COG1501	Belongs to the glycosyl hydrolase 31 family
FEZ32_RS05655	COG1737	Transcriptional regulator
FEZ32_RS05680	COG2318	DinB family
FEZ32_RS05715	COG0535	radical SAM domain protein
FEZ32_RS05725	COG0022	dehydrogenase e1 component
FEZ32_RS05730	COG0508	dehydrogenase complex catalyzes the overall conversion of
FEZ32_RS05740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FEZ32_RS05750	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FEZ32_RS05755	COG0077	Prephenate dehydratase
FEZ32_RS05760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FEZ32_RS05785	COG0561	phosphatase activity
FEZ32_RS05825	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FEZ32_RS05830	COG1609	Transcriptional regulator
FEZ32_RS05855	COG0584	glycerophosphoryl diester phosphodiesterase
FEZ32_RS05860	COG0823	Involved in the tonB-independent uptake of proteins
FEZ32_RS05860	COG1506	peptidase
FEZ32_RS05860	COG4946	Tricorn protease homolog
FEZ32_RS05875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FEZ32_RS05885	COG0590	tRNA wobble adenosine to inosine editing
FEZ32_RS05930	COG1174	glycine betaine transport
FEZ32_RS05945	COG3263	regulation of cellular component size
FEZ32_RS05970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FEZ32_RS05975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEZ32_RS05980	COG1609	Transcriptional regulator
FEZ32_RS05985	COG1129	ABC transporter
FEZ32_RS05990	COG1172	Belongs to the binding-protein-dependent transport system permease family
FEZ32_RS06000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FEZ32_RS06005	COG1869	D-ribose catabolic process
FEZ32_RS06030	COG4821	SIS domain
FEZ32_RS06040	COG4572	Cation transport regulator
FEZ32_RS06045	COG1295	ribonuclease BN
FEZ32_RS06065	COG1028	Short-chain dehydrogenase reductase Sdr
FEZ32_RS06075	COG3285	dna ligase
FEZ32_RS06075	COG1793	dna ligase
FEZ32_RS06105	COG3328	transposase activity
FEZ32_RS06115	COG2807	transmembrane transport
FEZ32_RS06160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FEZ32_RS06165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FEZ32_RS06170	COG1072	(Pantothenic acid kinase))
FEZ32_RS06175	COG0519	Catalyzes the synthesis of GMP from XMP
FEZ32_RS06185	COG3328	transposase activity
FEZ32_RS06195	COG3022	response to hydroperoxide
FEZ32_RS06205	COG4608	Belongs to the ABC transporter superfamily
FEZ32_RS06210	COG0444	Belongs to the ABC transporter superfamily
FEZ32_RS06215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FEZ32_RS06220	COG0601	transmembrane transport
FEZ32_RS06240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FEZ32_RS06300	COG1408	metallophosphoesterase
FEZ32_RS06305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FEZ32_RS06325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FEZ32_RS06335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FEZ32_RS06390	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FEZ32_RS06395	COG1205	dead DEAH box helicase
FEZ32_RS06395	COG1111	helicase
FEZ32_RS06400	COG2890	protein-(glutamine-N5) methyltransferase activity
FEZ32_RS06410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FEZ32_RS06410	COG1754	DNA topoisomerase type I activity
FEZ32_RS06420	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FEZ32_RS06425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FEZ32_RS06435	COG1774	PSP1 C-terminal conserved region
FEZ32_RS06485	COG1063	alcohol dehydrogenase
FEZ32_RS06495	COG1231	oxidoreductase activity
FEZ32_RS06510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FEZ32_RS06510	COG0519	Catalyzes the synthesis of GMP from XMP
FEZ32_RS06530	COG0601	transmembrane transport
FEZ32_RS06535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FEZ32_RS06595	COG3458	cephalosporin-C deacetylase activity
FEZ32_RS06605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FEZ32_RS06615	COG0037	tRNA processing
FEZ32_RS06630	COG0302	gtp cyclohydrolase
FEZ32_RS06640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FEZ32_RS06695	COG2409	Drug exporters of the RND superfamily
FEZ32_RS06725	COG3842	ATPase activity
FEZ32_RS06735	COG2271	Major facilitator Superfamily
FEZ32_RS06740	COG0445	tRNA wobble uridine modification
FEZ32_RS06745	COG1609	Transcriptional regulator
FEZ32_RS06760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FEZ32_RS06765	COG0113	porphobilinogen synthase activity
FEZ32_RS06775	COG0181	hydroxymethylbilane synthase activity
FEZ32_RS06785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FEZ32_RS06790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FEZ32_RS06795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FEZ32_RS06795	COG3253	May function as heme-dependent peroxidase
FEZ32_RS06810	COG3655	Transcriptional regulator
FEZ32_RS06820	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
FEZ32_RS06825	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FEZ32_RS06835	COG1082	Xylose isomerase domain protein TIM barrel
FEZ32_RS06840	COG0506	proline dehydrogenase activity
FEZ32_RS06855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FEZ32_RS06870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FEZ32_RS06875	COG0406	alpha-ribazole phosphatase activity
FEZ32_RS06880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FEZ32_RS06885	COG0785	Cytochrome C biogenesis protein
FEZ32_RS06895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FEZ32_RS06905	COG4221	oxidoreductase activity
FEZ32_RS06915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FEZ32_RS06935	COG1132	(ABC) transporter
FEZ32_RS06935	COG2375	cellular response to nickel ion
FEZ32_RS06940	COG1120	ATPase activity
FEZ32_RS06945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FEZ32_RS06950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FEZ32_RS06955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FEZ32_RS06960	COG1132	(ABC) transporter
FEZ32_RS06965	COG1132	(ABC) transporter
FEZ32_RS06975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FEZ32_RS06980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FEZ32_RS06985	COG0254	rRNA binding
FEZ32_RS06990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FEZ32_RS06995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FEZ32_RS07010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FEZ32_RS07020	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FEZ32_RS07025	COG0745	RESPONSE REGULATOR receiver
FEZ32_RS07045	COG1490	D-aminoacyl-tRNA deacylase activity
FEZ32_RS07055	COG3485	protocatechuate 3,4-dioxygenase
FEZ32_RS07065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FEZ32_RS07080	COG4991	sh3 domain protein
FEZ32_RS07080	COG3103	Sh3 type 3 domain protein
FEZ32_RS07080	COG0860	N-Acetylmuramoyl-L-alanine amidase
FEZ32_RS07085	COG1217	gtp-binding protein TYPA
FEZ32_RS07090	COG2814	Major facilitator Superfamily
FEZ32_RS07125	COG1737	Transcriptional regulator
FEZ32_RS07135	COG2801	Transposase and inactivated derivatives
FEZ32_RS07150	COG1737	Transcriptional regulator
FEZ32_RS07185	COG2801	Transposase and inactivated derivatives
FEZ32_RS07205	COG2337	Toxic component of a toxin-antitoxin (TA) module
FEZ32_RS07215	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEZ32_RS07220	COG1937	Protein conserved in bacteria
FEZ32_RS07235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FEZ32_RS07240	COG0697	spore germination
FEZ32_RS07250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FEZ32_RS07255	COG0583	DNA-binding transcription factor activity
FEZ32_RS07270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FEZ32_RS07275	COG0047	phosphoribosylformylglycinamidine synthase activity
FEZ32_RS07280	COG1113	amino acid transport
FEZ32_RS07285	COG0252	asparaginase activity
FEZ32_RS07305	COG3415	Transposase
FEZ32_RS07305	COG2801	Transposase and inactivated derivatives
FEZ32_RS07310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FEZ32_RS07330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEZ32_RS07340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FEZ32_RS07345	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FEZ32_RS07365	COG1175	transmembrane transport
FEZ32_RS07370	COG0395	ABC-type sugar transport system, permease component
FEZ32_RS07480	COG4974	Belongs to the 'phage' integrase family
FEZ32_RS07510	COG4133	protoheme IX ABC transporter activity
FEZ32_RS07540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FEZ32_RS07545	COG1834	amidinotransferase
FEZ32_RS07550	COG0531	amino acid
FEZ32_RS07590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FEZ32_RS07590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEZ32_RS07590	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FEZ32_RS07595	COG1461	Dihydroxyacetone kinase
FEZ32_RS07600	COG2376	Dihydroxyacetone kinase
FEZ32_RS07605	COG2814	Major facilitator Superfamily
FEZ32_RS07615	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FEZ32_RS07620	COG1132	(ABC) transporter
FEZ32_RS07630	COG2226	methyltransferase
FEZ32_RS07660	COG0644	oxidoreductase
FEZ32_RS07670	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FEZ32_RS07675	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FEZ32_RS07680	COG0649	NAD binding
FEZ32_RS07690	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FEZ32_RS07695	COG1034	ATP synthesis coupled electron transport
FEZ32_RS07700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FEZ32_RS07705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FEZ32_RS07715	COG0713	ATP synthesis coupled electron transport
FEZ32_RS07730	COG1007	ATP synthesis coupled electron transport
FEZ32_RS07735	COG0142	geranyltranstransferase activity
FEZ32_RS07750	COG2301	Belongs to the HpcH HpaI aldolase family
FEZ32_RS07755	COG3590	peptidase
FEZ32_RS07765	COG1013	pyruvate-flavodoxin oxidoreductase activity
FEZ32_RS07770	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FEZ32_RS07770	COG0674	pyruvate-flavodoxin oxidoreductase activity
FEZ32_RS07780	COG1024	Enoyl-CoA hydratase
FEZ32_RS07785	COG0708	Exodeoxyribonuclease III
FEZ32_RS07795	COG1666	GTP binding
FEZ32_RS07815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FEZ32_RS07820	COG2030	dehydratase
FEZ32_RS07830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FEZ32_RS07835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEZ32_RS07850	COG0250	Participates in transcription elongation, termination and antitermination
FEZ32_RS07855	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FEZ32_RS07860	COG0081	regulation of translation
FEZ32_RS07865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FEZ32_RS07870	COG0222	ribosome binding
FEZ32_RS07875	COG0085	RNA polymerase activity
FEZ32_RS07880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FEZ32_RS07885	COG0673	inositol 2-dehydrogenase activity
FEZ32_RS07890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FEZ32_RS07895	COG0049	tRNA binding
FEZ32_RS07900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FEZ32_RS07905	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FEZ32_RS07920	COG0737	Belongs to the 5'-nucleotidase family
FEZ32_RS07925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FEZ32_RS07930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FEZ32_RS07935	COG0051	transcription antitermination factor activity, RNA binding
FEZ32_RS07940	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FEZ32_RS07945	COG0088	Forms part of the polypeptide exit tunnel
FEZ32_RS07950	COG0089	rRNA binding
FEZ32_RS07955	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FEZ32_RS07960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FEZ32_RS07965	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FEZ32_RS07970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FEZ32_RS07975	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FEZ32_RS07980	COG0255	Belongs to the universal ribosomal protein uL29 family
FEZ32_RS07985	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FEZ32_RS08000	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FEZ32_RS08005	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FEZ32_RS08010	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FEZ32_RS08015	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FEZ32_RS08020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FEZ32_RS08025	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FEZ32_RS08030	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FEZ32_RS08035	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FEZ32_RS08040	COG1841	ribosomal large subunit assembly
FEZ32_RS08045	COG0200	Binds to the 23S rRNA
FEZ32_RS08080	COG0563	adenylate kinase activity
FEZ32_RS08100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FEZ32_RS08105	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FEZ32_RS08115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FEZ32_RS08120	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FEZ32_RS08125	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FEZ32_RS08130	COG0202	RNA polymerase activity
FEZ32_RS08135	COG0203	ribosomal protein L17
FEZ32_RS08140	COG0438	transferase activity, transferring glycosyl groups
FEZ32_RS08165	COG3845	ABC transporter
FEZ32_RS08180	COG0101	tRNA pseudouridine synthase activity
FEZ32_RS08185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FEZ32_RS08190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FEZ32_RS08195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FEZ32_RS08200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FEZ32_RS08210	COG1072	(Pantothenic acid kinase))
FEZ32_RS08215	COG2264	protein methyltransferase activity
FEZ32_RS08220	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FEZ32_RS08225	COG0736	holo-[acyl-carrier-protein] synthase activity
FEZ32_RS08230	COG1940	carbohydrate kinase activity
FEZ32_RS08230	COG1846	Transcriptional regulator
FEZ32_RS08245	COG1175	transmembrane transport
FEZ32_RS08255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FEZ32_RS08255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FEZ32_RS08265	COG0513	Belongs to the DEAD box helicase family
FEZ32_RS08270	COG0802	atpase or kinase
FEZ32_RS08275	COG0456	acetyltransferase
FEZ32_RS08275	COG1214	PFAM Peptidase M22, glycoprotease
FEZ32_RS08280	COG0456	acetyltransferase
FEZ32_RS08285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FEZ32_RS08330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FEZ32_RS08335	COG0459	protein refolding
FEZ32_RS08350	COG0516	GMP reductase activity
FEZ32_RS08360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FEZ32_RS08365	COG1605	Chorismate mutase
FEZ32_RS08365	COG0287	Prephenate dehydrogenase
FEZ32_RS08370	COG1045	serine acetyltransferase
FEZ32_RS08375	COG0519	Catalyzes the synthesis of GMP from XMP
FEZ32_RS08375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FEZ32_RS08400	COG2197	response regulator
FEZ32_RS08405	COG2261	transglycosylase associated protein
FEZ32_RS08410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FEZ32_RS08415	COG2011	ABC-type metal ion transport system permease component
FEZ32_RS08420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FEZ32_RS08425	COG1464	Belongs to the NlpA lipoprotein family
FEZ32_RS08440	COG0045	succinate-CoA ligase (ADP-forming) activity
FEZ32_RS08470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FEZ32_RS08470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FEZ32_RS08475	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FEZ32_RS08485	COG0138	bifunctional purine biosynthesis protein purh
FEZ32_RS08500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FEZ32_RS08510	COG0039	L-malate dehydrogenase activity
FEZ32_RS08525	COG1253	flavin adenine dinucleotide binding
FEZ32_RS08535	COG1744	ABC transporter substrate-binding protein PnrA-like
FEZ32_RS08540	COG3845	ABC transporter
FEZ32_RS08545	COG4603	Belongs to the binding-protein-dependent transport system permease family
FEZ32_RS08550	COG1079	Belongs to the binding-protein-dependent transport system permease family
FEZ32_RS08560	COG0328	RNA-DNA hybrid ribonuclease activity
FEZ32_RS08565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEZ32_RS08580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FEZ32_RS08595	COG4770	biotin carboxylase activity
FEZ32_RS08605	COG0351	phosphomethylpyrimidine kinase
FEZ32_RS08610	COG4221	oxidoreductase activity
FEZ32_RS08615	COG2235	arginine
FEZ32_RS08625	COG0424	maF-like protein
FEZ32_RS08635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FEZ32_RS08640	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FEZ32_RS08640	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FEZ32_RS08645	COG3340	Belongs to the peptidase S51 family
FEZ32_RS08665	COG1316	TRANSCRIPTIONal
FEZ32_RS08725	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FEZ32_RS08730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FEZ32_RS08760	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FEZ32_RS08775	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FEZ32_RS08775	COG1918	ferrous iron import across plasma membrane
FEZ32_RS08785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FEZ32_RS08790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FEZ32_RS08795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FEZ32_RS08800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FEZ32_RS08805	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FEZ32_RS08810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FEZ32_RS08895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FEZ32_RS08930	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FEZ32_RS08945	COG0587	DNA-directed DNA polymerase activity
FEZ32_RS08955	COG2801	Transposase and inactivated derivatives
FEZ32_RS08970	COG0531	amino acid
FEZ32_RS08975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FEZ32_RS08990	COG1113	amino acid transport
FEZ32_RS08995	COG1321	iron dependent repressor
FEZ32_RS08995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FEZ32_RS09000	COG1914	H( )-stimulated, divalent metal cation uptake system
FEZ32_RS09010	COG0604	alcohol dehydrogenase
FEZ32_RS09050	COG1305	Transglutaminase-like
FEZ32_RS09100	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FEZ32_RS09115	COG0629	single-stranded DNA binding
FEZ32_RS09130	COG1757	Na H antiporter
FEZ32_RS09135	COG2235	arginine
FEZ32_RS09160	COG3328	transposase activity
FEZ32_RS09170	COG0277	FAD linked oxidase domain protein
FEZ32_RS09170	COG0247	lactate metabolic process
FEZ32_RS09185	COG1022	Amp-dependent synthetase and ligase
FEZ32_RS09200	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FEZ32_RS09215	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FEZ32_RS09220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FEZ32_RS09235	COG0698	ribose 5-phosphate isomerase
FEZ32_RS09255	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FEZ32_RS09255	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FEZ32_RS09275	COG0544	peptidyl-prolyl cis-trans isomerase activity
FEZ32_RS09285	COG0740	serine-type endopeptidase activity
FEZ32_RS09290	COG0740	serine-type endopeptidase activity
FEZ32_RS09295	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FEZ32_RS09300	COG4946	Tricorn protease homolog
FEZ32_RS09300	COG0793	Belongs to the peptidase S41A family
FEZ32_RS09310	COG0525	valine-tRNA ligase activity
FEZ32_RS09320	COG0363	glucosamine-6-phosphate deaminase activity
FEZ32_RS09335	COG0109	protoheme IX farnesyltransferase activity
FEZ32_RS09345	COG1612	heme a metabolic process
FEZ32_RS09355	COG1131	(ABC) transporter
FEZ32_RS09360	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FEZ32_RS09365	COG1609	Transcriptional regulator
FEZ32_RS09370	COG3833	ABC-type maltose transport systems, permease component
FEZ32_RS09375	COG1175	transmembrane transport
FEZ32_RS09405	COG0396	ATPase activity
FEZ32_RS09410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FEZ32_RS09450	COG0488	(ABC) transporter
FEZ32_RS09460	COG2226	methyltransferase
FEZ32_RS09495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FEZ32_RS09500	COG1119	ATPase activity
FEZ32_RS09535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FEZ32_RS09545	COG4608	Belongs to the ABC transporter superfamily
FEZ32_RS09555	COG0242	peptide deformylase activity
FEZ32_RS09565	COG4974	Belongs to the 'phage' integrase family
FEZ32_RS09570	COG0739	heme binding
FEZ32_RS09570	COG0741	lytic transglycosylase activity
FEZ32_RS09570	COG1196	nuclear chromosome segregation
FEZ32_RS09575	COG0052	Belongs to the universal ribosomal protein uS2 family
FEZ32_RS09580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FEZ32_RS09585	COG0528	UMP kinase activity
FEZ32_RS09590	COG0233	cytoplasmic translational termination
FEZ32_RS09595	COG0575	Belongs to the CDS family
FEZ32_RS09600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FEZ32_RS09605	COG0387	Pfam Sodium calcium exchanger
FEZ32_RS09610	COG0750	zinc metalloprotease
FEZ32_RS09615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FEZ32_RS09635	COG1305	Transglutaminase-like
FEZ32_RS09640	COG0442	prolyl-tRNA aminoacylation
FEZ32_RS09655	COG0779	Required for maturation of 30S ribosomal subunits
FEZ32_RS09670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FEZ32_RS09675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FEZ32_RS09680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FEZ32_RS09685	COG0196	riboflavin kinase activity
FEZ32_RS09690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FEZ32_RS09710	COG1185	polyribonucleotide nucleotidyltransferase activity
FEZ32_RS09730	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FEZ32_RS09740	COG0028	Belongs to the TPP enzyme family
FEZ32_RS09750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FEZ32_RS09755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FEZ32_RS09760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FEZ32_RS09770	COG0742	ribosomal rna small subunit methyltransferase
FEZ32_RS09775	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FEZ32_RS09785	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FEZ32_RS09790	COG0571	ribonuclease III activity
FEZ32_RS09795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FEZ32_RS09850	COG0228	four-way junction DNA binding
FEZ32_RS09855	COG1837	Belongs to the UPF0109 family
FEZ32_RS09860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FEZ32_RS09865	COG0336	Belongs to the RNA methyltransferase TrmD family
FEZ32_RS09875	COG1053	succinate dehydrogenase
FEZ32_RS09880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FEZ32_RS09890	COG0335	large ribosomal subunit rRNA binding
FEZ32_RS09895	COG0681	Belongs to the peptidase S26 family
FEZ32_RS09900	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FEZ32_RS09910	COG0792	nuclease activity
FEZ32_RS09965	COG2801	Transposase and inactivated derivatives
FEZ32_RS09990	COG0745	RESPONSE REGULATOR receiver
FEZ32_RS09995	COG1968	undecaprenyl-diphosphatase activity
FEZ32_RS10000	COG0671	phosphoesterase, PA-phosphatase related
FEZ32_RS10005	COG0390	transport system, permease component
FEZ32_RS10045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEZ32_RS10055	COG0667	Aldo Keto reductase
FEZ32_RS10065	COG3201	nicotinamide mononucleotide transporter
FEZ32_RS10070	COG0140	phosphoribosyl-ATP diphosphatase activity
FEZ32_RS10075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FEZ32_RS10110	COG0647	UMP catabolic process
FEZ32_RS10115	COG1268	BioY protein
FEZ32_RS10120	COG1122	ATPase activity
FEZ32_RS10130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FEZ32_RS10135	COG0497	DNA recombination
FEZ32_RS10140	COG0504	CTP synthase activity
FEZ32_RS10145	COG0494	nUDIX hydrolase
FEZ32_RS10150	COG4974	Belongs to the 'phage' integrase family
FEZ32_RS10175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FEZ32_RS10185	COG2378	regulation of single-species biofilm formation
FEZ32_RS10210	COG4581	dead DEAH box helicase
FEZ32_RS10215	COG0107	imidazoleglycerol-phosphate synthase activity
FEZ32_RS10220	COG0537	adenosine 5'-monophosphoramidase activity
FEZ32_RS10230	COG0440	acetolactate synthase activity
FEZ32_RS10235	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FEZ32_RS10245	COG0473	3-isopropylmalate dehydrogenase activity
FEZ32_RS10250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FEZ32_RS10255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FEZ32_RS10265	COG0179	Fumarylacetoacetate (FAA) hydrolase
FEZ32_RS10270	COG1266	CAAX protease self-immunity
FEZ32_RS10285	COG1414	Transcriptional regulator
FEZ32_RS10290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FEZ32_RS10295	COG0066	3-isopropylmalate dehydratase activity
FEZ32_RS10305	COG1181	Belongs to the D-alanine--D-alanine ligase family
FEZ32_RS10325	COG1674	ftsk spoiiie
FEZ32_RS10345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FEZ32_RS10350	COG2884	Cell division ATP-binding protein ftsE
FEZ32_RS10360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FEZ32_RS10365	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FEZ32_RS10370	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FEZ32_RS10375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FEZ32_RS10380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FEZ32_RS10390	COG0165	Argininosuccinate lyase
FEZ32_RS10420	COG1678	Uncharacterized ACR, COG1678
FEZ32_RS10425	COG0745	RESPONSE REGULATOR receiver
FEZ32_RS10430	COG5002	protein histidine kinase activity
FEZ32_RS10430	COG5000	phosphorelay sensor kinase activity
FEZ32_RS10435	COG5401	PFAM Sporulation and spore germination
FEZ32_RS10445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FEZ32_RS10455	COG0653	protein targeting
FEZ32_RS10475	COG2902	Dehydrogenase
FEZ32_RS10485	COG0180	Tryptophanyl-tRNA synthetase
FEZ32_RS10515	COG1278	Cold shock
FEZ32_RS10520	COG1074	ATP-dependent DNA helicase activity
FEZ32_RS10545	COG1074	ATP-dependent DNA helicase activity
FEZ32_RS10575	COG3480	Lon protease (S16) C-terminal proteolytic domain
FEZ32_RS10585	COG1615	UPF0182 protein
FEZ32_RS10590	COG1472	Belongs to the glycosyl hydrolase 3 family
FEZ32_RS10620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FEZ32_RS10630	COG4608	Belongs to the ABC transporter superfamily
FEZ32_RS10635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FEZ32_RS10640	COG0483	inositol monophosphate 1-phosphatase activity
FEZ32_RS10655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FEZ32_RS10665	COG1595	DNA-templated transcription, initiation
FEZ32_RS10690	COG0567	Dehydrogenase, E1 component
FEZ32_RS10690	COG0508	dehydrogenase complex catalyzes the overall conversion of
FEZ32_RS10700	COG1611	Belongs to the LOG family
FEZ32_RS10715	COG0460	homoserine dehydrogenase
FEZ32_RS10720	COG0083	homoserine kinase activity
FEZ32_RS10730	COG0254	rRNA binding
FEZ32_RS10735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FEZ32_RS10740	COG2890	protein-(glutamine-N5) methyltransferase activity
FEZ32_RS10750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FEZ32_RS10760	COG2244	polysaccharide biosynthetic process
FEZ32_RS10830	COG0736	holo-[acyl-carrier-protein] synthase activity
FEZ32_RS10835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FEZ32_RS10840	COG0367	asparagine synthase
FEZ32_RS10845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FEZ32_RS10865	COG0356	it plays a direct role in the translocation of protons across the membrane
FEZ32_RS10875	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FEZ32_RS10880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FEZ32_RS10885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FEZ32_RS10890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FEZ32_RS10895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FEZ32_RS10900	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FEZ32_RS10915	COG0596	Alpha beta hydrolase
FEZ32_RS10965	COG3328	transposase activity
FEZ32_RS10970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FEZ32_RS10980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FEZ32_RS10985	COG1560	Kdo2-lipid A biosynthetic process
FEZ32_RS10990	COG0438	transferase activity, transferring glycosyl groups
FEZ32_RS11010	COG0509	glycine decarboxylation via glycine cleavage system
FEZ32_RS11015	COG1716	ATPase activity
FEZ32_RS11035	COG1295	ribonuclease BN
FEZ32_RS11040	COG0205	6-phosphofructokinase activity
FEZ32_RS11050	COG0009	L-threonylcarbamoyladenylate synthase
FEZ32_RS11055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FEZ32_RS11060	COG1597	lipid kinase activity
FEZ32_RS11065	COG1472	Belongs to the glycosyl hydrolase 3 family
FEZ32_RS11070	COG1739	Uncharacterized protein family UPF0029
FEZ32_RS11080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FEZ32_RS11115	COG0531	amino acid
FEZ32_RS11130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FEZ32_RS11135	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FEZ32_RS11140	COG0584	glycerophosphoryl diester phosphodiesterase
FEZ32_RS11150	COG1216	Glycosyl transferase, family 2
FEZ32_RS11155	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FEZ32_RS11160	COG1522	sequence-specific DNA binding
FEZ32_RS11165	COG2813	Specifically methylates the guanine in position
FEZ32_RS11165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FEZ32_RS11170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FEZ32_RS11175	COG0427	acetyl-CoA hydrolase
FEZ32_RS11185	COG0561	phosphatase activity
FEZ32_RS11285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FEZ32_RS11305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FEZ32_RS11315	COG0028	Belongs to the TPP enzyme family
FEZ32_RS11345	COG0604	alcohol dehydrogenase
FEZ32_RS11345	COG3321	synthase
FEZ32_RS11350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FEZ32_RS11355	COG0384	phenazine biosynthesis protein PhzF
FEZ32_RS11460	COG1764	response to oxidative stress
FEZ32_RS11475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FEZ32_RS11485	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FEZ32_RS11490	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FEZ32_RS11505	COG1410	methionine synthase
FEZ32_RS11505	COG0646	methionine synthase
FEZ32_RS11515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FEZ32_RS11525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FEZ32_RS11545	COG1201	RNA secondary structure unwinding
FEZ32_RS11550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FEZ32_RS11560	COG1758	RNA polymerase activity
FEZ32_RS11565	COG0194	GDP metabolic process
FEZ32_RS11575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FEZ32_RS11580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FEZ32_RS11590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FEZ32_RS11600	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FEZ32_RS11605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FEZ32_RS11610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FEZ32_RS11615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FEZ32_RS11620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FEZ32_RS11650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FEZ32_RS11660	COG1309	transcriptional regulator
FEZ32_RS11680	COG0124	histidyl-tRNA synthetase
FEZ32_RS11690	COG1196	nuclear chromosome segregation
FEZ32_RS11695	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FEZ32_RS11700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FEZ32_RS11710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FEZ32_RS11715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FEZ32_RS11720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FEZ32_RS11730	COG2255	four-way junction helicase activity
FEZ32_RS11735	COG0632	four-way junction helicase activity
FEZ32_RS11740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FEZ32_RS11745	COG0217	transcriptional regulatory protein
FEZ32_RS11750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FEZ32_RS11755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FEZ32_RS11760	COG0131	Imidazoleglycerol-phosphate dehydratase
FEZ32_RS11765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FEZ32_RS11770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FEZ32_RS11800	COG0070	glutamate synthase
FEZ32_RS11800	COG0067	glutamate synthase
FEZ32_RS11800	COG0069	glutamate synthase activity
FEZ32_RS11805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FEZ32_RS11810	COG0159	tryptophan synthase activity
FEZ32_RS11815	COG0133	tryptophan synthase activity
FEZ32_RS11820	COG0134	indole-3-glycerol-phosphate synthase activity
FEZ32_RS11835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FEZ32_RS11840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FEZ32_RS11855	COG2233	PERMEase
FEZ32_RS11860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FEZ32_RS11865	COG0154	amidase activity
FEZ32_RS11870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FEZ32_RS11885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FEZ32_RS11895	COG1116	anion transmembrane transporter activity
FEZ32_RS11910	COG0482	sulfurtransferase activity
FEZ32_RS11930	COG0366	Alpha amylase catalytic
FEZ32_RS11935	COG3281	Trehalose synthase
FEZ32_RS11940	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FEZ32_RS11965	COG0033	Phosphoglucomutase
FEZ32_RS12000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FEZ32_RS12015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FEZ32_RS12020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FEZ32_RS12025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FEZ32_RS12030	COG0531	amino acid
FEZ32_RS12035	COG0569	domain protein
FEZ32_RS12055	COG0756	dUTP diphosphatase activity
FEZ32_RS12090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FEZ32_RS12110	COG0187	DNA topoisomerase II activity
FEZ32_RS12130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FEZ32_RS12140	COG1946	Acyl-CoA thioesterase
FEZ32_RS12145	COG5426	von Willebrand factor, type A
FEZ32_RS12150	COG1643	Atp-dependent helicase
FEZ32_RS12170	COG0717	Belongs to the dCTP deaminase family
FEZ32_RS12175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FEZ32_RS12180	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FEZ32_RS12195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FEZ32_RS12200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FEZ32_RS12205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FEZ32_RS12215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FEZ32_RS12220	COG2017	converts alpha-aldose to the beta-anomer
FEZ32_RS12225	COG1418	mRNA catabolic process
FEZ32_RS12230	COG2137	regulation of response to DNA damage stimulus
FEZ32_RS12245	COG1349	DNA-binding transcription factor activity
FEZ32_RS12255	COG1546	Belongs to the CinA family
FEZ32_RS12255	COG1058	Belongs to the CinA family
FEZ32_RS12265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FEZ32_RS12275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FEZ32_RS12280	COG0284	orotidine-5'-phosphate decarboxylase activity
FEZ32_RS12285	COG0167	dihydroorotate dehydrogenase activity
FEZ32_RS12290	COG0543	2 iron, 2 sulfur cluster binding
FEZ32_RS12295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FEZ32_RS12310	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FEZ32_RS12330	COG0667	Aldo Keto reductase
FEZ32_RS12340	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FEZ32_RS12355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FEZ32_RS12365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FEZ32_RS12370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FEZ32_RS12385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FEZ32_RS12395	COG2304	oxidoreductase activity
FEZ32_RS12405	COG0714	Associated with various cellular activities
FEZ32_RS12435	COG0515	serine threonine protein kinase
FEZ32_RS12445	COG2818	Glycosylase
FEZ32_RS12450	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FEZ32_RS12455	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FEZ32_RS12460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEZ32_RS12475	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FEZ32_RS12480	COG0488	(ABC) transporter
FEZ32_RS12485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FEZ32_RS12505	COG0358	DNA primase activity
FEZ32_RS12510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FEZ32_RS12530	COG1053	succinate dehydrogenase
FEZ32_RS12545	COG1051	belongs to the nudix hydrolase family
FEZ32_RS12550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FEZ32_RS12555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FEZ32_RS12565	COG0423	glycine-tRNA ligase activity
FEZ32_RS12570	COG0735	belongs to the Fur family
FEZ32_RS12590	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEZ32_RS12625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FEZ32_RS12645	COG2801	Transposase and inactivated derivatives
FEZ32_RS12645	COG3415	Transposase
FEZ32_RS12710	COG1381	Involved in DNA repair and RecF pathway recombination
FEZ32_RS12715	COG1404	Belongs to the peptidase S8 family
FEZ32_RS12720	COG0475	glutathione-regulated potassium exporter activity
FEZ32_RS12720	COG0569	domain protein
FEZ32_RS12725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FEZ32_RS12735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FEZ32_RS12745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FEZ32_RS12755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FEZ32_RS12770	COG2226	methyltransferase
FEZ32_RS12795	COG1668	transmembrane transport
FEZ32_RS12800	COG4152	abc transporter atp-binding protein
FEZ32_RS12805	COG2197	response regulator
FEZ32_RS12810	COG4585	Histidine kinase
FEZ32_RS12815	COG0343	queuine tRNA-ribosyltransferase activity
FEZ32_RS12825	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FEZ32_RS12835	COG2259	Doxx family
FEZ32_RS12845	COG0484	heat shock protein binding
FEZ32_RS12850	COG1420	regulation of RNA biosynthetic process
FEZ32_RS12870	COG0483	inositol monophosphate 1-phosphatase activity
FEZ32_RS12890	COG1175	transmembrane transport
FEZ32_RS12895	COG0395	ABC-type sugar transport system, permease component
FEZ32_RS12905	COG1309	transcriptional regulator
FEZ32_RS12910	COG1131	(ABC) transporter
FEZ32_RS12920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FEZ32_RS12930	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FEZ32_RS12945	COG1169	isochorismate synthase
FEZ32_RS12950	COG0488	(ABC) transporter
FEZ32_RS12955	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FEZ32_RS12960	COG4948	Mandelate Racemase Muconate Lactonizing
FEZ32_RS12965	COG0481	GTPase activity
FEZ32_RS12970	COG0268	Binds directly to 16S ribosomal RNA
FEZ32_RS12980	COG1061	Type III restriction enzyme res subunit
FEZ32_RS12995	COG0495	leucyl-tRNA aminoacylation
FEZ32_RS13010	COG0366	Alpha amylase catalytic
FEZ32_RS13015	COG2217	Heavy metal translocating P-type atpase
FEZ32_RS13025	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FEZ32_RS13030	COG0352	thiamine-phosphate diphosphorylase activity
FEZ32_RS13080	COG1396	sequence-specific DNA binding
FEZ32_RS13110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FEZ32_RS13125	COG2801	Transposase and inactivated derivatives
FEZ32_RS13140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FEZ32_RS13190	COG3328	transposase activity
FEZ32_RS13245	COG0406	alpha-ribazole phosphatase activity
FEZ32_RS13255	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FEZ32_RS13260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FEZ32_RS13265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FEZ32_RS13270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FEZ32_RS13280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FEZ32_RS13285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FEZ32_RS13290	COG1530	ribonuclease E activity
FEZ32_RS13295	COG1472	Belongs to the glycosyl hydrolase 3 family
FEZ32_RS13300	COG0105	UTP biosynthetic process
FEZ32_RS13310	COG0285	dihydrofolate synthase activity
FEZ32_RS13320	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FEZ32_RS13325	COG0149	triose-phosphate isomerase activity
FEZ32_RS13330	COG0126	phosphoglycerate kinase activity
FEZ32_RS13335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FEZ32_RS13340	COG1481	regulation of sporulation
FEZ32_RS13350	COG1660	Displays ATPase and GTPase activities
FEZ32_RS13355	COG0322	excinuclease ABC activity
FEZ32_RS13400	COG0556	nucleotide-excision repair
FEZ32_RS13405	COG0237	dephospho-CoA kinase activity
FEZ32_RS13410	COG0539	negative regulation of cytoplasmic translation