locus-tag	class	description
C0Z11_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C0Z11_RS00010	COG0577	efflux transmembrane transporter activity
C0Z11_RS00010	COG1136	(ABC) transporter
C0Z11_RS00015	COG0577	efflux transmembrane transporter activity
C0Z11_RS00020	COG0592	DNA-directed DNA polymerase activity
C0Z11_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0Z11_RS00035	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C0Z11_RS00040	COG1482	cell wall glycoprotein biosynthetic process
C0Z11_RS00045	COG3250	beta-galactosidase activity
C0Z11_RS00055	COG0187	DNA topoisomerase II activity
C0Z11_RS00060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C0Z11_RS00065	COG3266	domain, Protein
C0Z11_RS00070	COG3711	transcriptional antiterminator
C0Z11_RS00070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z11_RS00080	COG2213	PTS system mannitol-specific
C0Z11_RS00085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z11_RS00090	COG0246	Mannitol dehydrogenase
C0Z11_RS00095	COG0673	inositol 2-dehydrogenase activity
C0Z11_RS00100	COG0039	L-malate dehydrogenase activity
C0Z11_RS00140	COG1737	Transcriptional regulator
C0Z11_RS00140	COG0837	glucose binding
C0Z11_RS00165	COG1609	Transcriptional regulator
C0Z11_RS00170	COG2271	Major facilitator Superfamily
C0Z11_RS00200	COG2814	Major facilitator Superfamily
C0Z11_RS00220	COG2272	Belongs to the type-B carboxylesterase lipase family
C0Z11_RS00225	COG0436	Aminotransferase
C0Z11_RS00230	COG1942	4-Oxalocrotonate Tautomerase
C0Z11_RS00235	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z11_RS00240	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z11_RS00240	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0Z11_RS00245	COG3715	PTS system
C0Z11_RS00250	COG3716	PTS system mannose fructose sorbose family IID component
C0Z11_RS00275	COG1131	(ABC) transporter
C0Z11_RS00285	COG0095	Lipoate-protein ligase
C0Z11_RS00290	COG0765	amino acid transport
C0Z11_RS00295	COG1126	abc transporter atp-binding protein
C0Z11_RS00300	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0Z11_RS00310	COG1653	transport
C0Z11_RS00315	COG1175	transmembrane transport
C0Z11_RS00320	COG0395	ABC-type sugar transport system, permease component
C0Z11_RS00330	COG0310	cobalt ion transport
C0Z11_RS00340	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C0Z11_RS00355	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C0Z11_RS00360	COG1797	cobyrinic acid a,c-diamide synthase activity
C0Z11_RS00365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0Z11_RS00365	COG1648	precorrin-2 dehydrogenase activity
C0Z11_RS00375	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C0Z11_RS00400	COG1854	S-ribosylhomocysteine lyase activity
C0Z11_RS00440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0Z11_RS00460	COG0540	Belongs to the ATCase OTCase family
C0Z11_RS00475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0Z11_RS00480	COG0114	fumarate hydratase activity
C0Z11_RS00545	COG1012	belongs to the aldehyde dehydrogenase family
C0Z11_RS00550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C0Z11_RS00560	COG3588	fructose-bisphosphate aldolase
C0Z11_RS00565	COG2197	response regulator
C0Z11_RS00570	COG4585	Histidine kinase
C0Z11_RS00580	COG1131	(ABC) transporter
C0Z11_RS00585	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C0Z11_RS00610	COG1136	(ABC) transporter
C0Z11_RS00610	COG0577	efflux transmembrane transporter activity
C0Z11_RS00615	COG2197	response regulator
C0Z11_RS00620	COG4585	Histidine kinase
C0Z11_RS00630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0Z11_RS00635	COG1309	transcriptional regulator
C0Z11_RS00640	COG2409	Drug exporters of the RND superfamily
C0Z11_RS00650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0Z11_RS00655	COG0281	malic enzyme
C0Z11_RS00680	COG1254	Belongs to the acylphosphatase family
C0Z11_RS00690	COG1042	CoA-binding domain protein
C0Z11_RS00690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0Z11_RS00690	COG0045	succinate-CoA ligase (ADP-forming) activity
C0Z11_RS00695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0Z11_RS00705	COG1136	(ABC) transporter
C0Z11_RS00720	COG0205	6-phosphofructokinase activity
C0Z11_RS00750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0Z11_RS00790	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C0Z11_RS00800	COG2205	protein histidine kinase activity
C0Z11_RS00820	COG1132	(ABC) transporter
C0Z11_RS00825	COG1132	(ABC) transporter
C0Z11_RS00830	COG0366	Alpha amylase catalytic
C0Z11_RS00840	COG1285	pathogenesis
C0Z11_RS00845	COG1501	Belongs to the glycosyl hydrolase 31 family
C0Z11_RS00870	COG2318	DinB family
C0Z11_RS00895	COG0530	calcium, potassium:sodium antiporter activity
C0Z11_RS00905	COG0535	radical SAM domain protein
C0Z11_RS00915	COG0022	dehydrogenase e1 component
C0Z11_RS00920	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0Z11_RS00930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0Z11_RS00940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C0Z11_RS00945	COG0077	Prephenate dehydratase
C0Z11_RS00950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0Z11_RS00965	COG0561	phosphatase activity
C0Z11_RS00990	COG0604	alcohol dehydrogenase
C0Z11_RS00995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C0Z11_RS01000	COG1609	Transcriptional regulator
C0Z11_RS01025	COG0584	glycerophosphoryl diester phosphodiesterase
C0Z11_RS01030	COG4946	Tricorn protease homolog
C0Z11_RS01030	COG1506	peptidase
C0Z11_RS01030	COG0823	Involved in the tonB-independent uptake of proteins
C0Z11_RS01050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C0Z11_RS01105	COG1174	glycine betaine transport
C0Z11_RS01120	COG3263	regulation of cellular component size
C0Z11_RS01145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C0Z11_RS01150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0Z11_RS01155	COG1609	Transcriptional regulator
C0Z11_RS01160	COG1129	ABC transporter
C0Z11_RS01165	COG1172	Belongs to the binding-protein-dependent transport system permease family
C0Z11_RS01175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0Z11_RS01180	COG1869	D-ribose catabolic process
C0Z11_RS01185	COG0673	inositol 2-dehydrogenase activity
C0Z11_RS01195	COG4821	SIS domain
C0Z11_RS01205	COG4572	Cation transport regulator
C0Z11_RS01215	COG1295	ribonuclease BN
C0Z11_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
C0Z11_RS01245	COG3285	dna ligase
C0Z11_RS01245	COG1793	dna ligase
C0Z11_RS01270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0Z11_RS01275	COG1518	maintenance of DNA repeat elements
C0Z11_RS01320	COG1715	Restriction endonuclease
C0Z11_RS01325	COG2807	transmembrane transport
C0Z11_RS01370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C0Z11_RS01375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0Z11_RS01380	COG1072	(Pantothenic acid kinase))
C0Z11_RS01385	COG0519	Catalyzes the synthesis of GMP from XMP
C0Z11_RS01400	COG3022	response to hydroperoxide
C0Z11_RS01410	COG4608	Belongs to the ABC transporter superfamily
C0Z11_RS01415	COG0444	Belongs to the ABC transporter superfamily
C0Z11_RS01420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0Z11_RS01425	COG0601	transmembrane transport
C0Z11_RS01450	COG1408	metallophosphoesterase
C0Z11_RS01455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0Z11_RS01475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0Z11_RS01540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C0Z11_RS01545	COG1205	dead DEAH box helicase
C0Z11_RS01545	COG1111	helicase
C0Z11_RS01550	COG2890	protein-(glutamine-N5) methyltransferase activity
C0Z11_RS01560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C0Z11_RS01560	COG1754	DNA topoisomerase type I activity
C0Z11_RS01570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C0Z11_RS01575	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C0Z11_RS01585	COG1774	PSP1 C-terminal conserved region
C0Z11_RS01635	COG1063	alcohol dehydrogenase
C0Z11_RS01645	COG1231	oxidoreductase activity
C0Z11_RS01650	COG0431	NADPH-dependent FMN reductase
C0Z11_RS01680	COG0601	transmembrane transport
C0Z11_RS01685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0Z11_RS01745	COG3458	cephalosporin-C deacetylase activity
C0Z11_RS01755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C0Z11_RS01765	COG0037	tRNA processing
C0Z11_RS01780	COG0302	gtp cyclohydrolase
C0Z11_RS01790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C0Z11_RS01820	COG0270	DNA (cytosine-5-)-methyltransferase activity
C0Z11_RS01875	COG2409	Drug exporters of the RND superfamily
C0Z11_RS01885	COG0705	Rhomboid family
C0Z11_RS01905	COG3842	ATPase activity
C0Z11_RS01915	COG2271	Major facilitator Superfamily
C0Z11_RS01920	COG0445	tRNA wobble uridine modification
C0Z11_RS01925	COG1609	Transcriptional regulator
C0Z11_RS01940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0Z11_RS01955	COG0181	hydroxymethylbilane synthase activity
C0Z11_RS01965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C0Z11_RS01970	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C0Z11_RS01975	COG3253	May function as heme-dependent peroxidase
C0Z11_RS01975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C0Z11_RS01985	COG3655	Transcriptional regulator
C0Z11_RS01995	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C0Z11_RS02000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C0Z11_RS02010	COG1082	Xylose isomerase domain protein TIM barrel
C0Z11_RS02015	COG0506	proline dehydrogenase activity
C0Z11_RS02030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0Z11_RS02045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0Z11_RS02050	COG0406	alpha-ribazole phosphatase activity
C0Z11_RS02055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0Z11_RS02060	COG0785	Cytochrome C biogenesis protein
C0Z11_RS02075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0Z11_RS02090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C0Z11_RS02100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0Z11_RS02120	COG2375	cellular response to nickel ion
C0Z11_RS02120	COG1132	(ABC) transporter
C0Z11_RS02125	COG1120	ATPase activity
C0Z11_RS02130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0Z11_RS02135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0Z11_RS02140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0Z11_RS02145	COG1132	(ABC) transporter
C0Z11_RS02150	COG1132	(ABC) transporter
C0Z11_RS02165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0Z11_RS02170	COG0254	rRNA binding
C0Z11_RS02175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C0Z11_RS02180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C0Z11_RS02195	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C0Z11_RS02205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C0Z11_RS02210	COG0745	RESPONSE REGULATOR receiver
C0Z11_RS02230	COG1490	D-aminoacyl-tRNA deacylase activity
C0Z11_RS02240	COG3485	protocatechuate 3,4-dioxygenase
C0Z11_RS02250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0Z11_RS02265	COG3103	Sh3 type 3 domain protein
C0Z11_RS02265	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0Z11_RS02265	COG4991	sh3 domain protein
C0Z11_RS02270	COG1217	gtp-binding protein TYPA
C0Z11_RS02275	COG2814	Major facilitator Superfamily
C0Z11_RS02310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0Z11_RS02310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0Z11_RS02315	COG0305	Participates in initiation and elongation during chromosome replication
C0Z11_RS02320	COG1937	Protein conserved in bacteria
C0Z11_RS02325	COG2608	mercury ion transmembrane transporter activity
C0Z11_RS02335	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C0Z11_RS02340	COG0167	dihydroorotate dehydrogenase activity
C0Z11_RS02345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C0Z11_RS02345	COG1013	pyruvate-flavodoxin oxidoreductase activity
C0Z11_RS02345	COG0674	pyruvate-flavodoxin oxidoreductase activity
C0Z11_RS02345	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C0Z11_RS02350	COG0493	'glutamate synthase
C0Z11_RS02350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0Z11_RS02355	COG2186	Transcriptional regulator
C0Z11_RS02360	COG1620	l-lactate permease
C0Z11_RS02365	COG0247	lactate metabolic process
C0Z11_RS02370	COG1139	Iron-sulfur cluster binding protein
C0Z11_RS02375	COG1556	Lactate utilization protein
C0Z11_RS02380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C0Z11_RS02385	COG4988	ABC transporter
C0Z11_RS02390	COG1294	oxidase, subunit
C0Z11_RS02395	COG1271	oxidase subunit
C0Z11_RS02430	COG1454	alcohol dehydrogenase
C0Z11_RS02450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0Z11_RS02465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0Z11_RS02470	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0Z11_RS02495	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C0Z11_RS02500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0Z11_RS02505	COG1953	Uracil, thiamine, allantoin
C0Z11_RS02520	COG0393	Putative heavy-metal-binding
C0Z11_RS02545	COG0515	serine threonine protein kinase
C0Z11_RS02550	COG0768	penicillin binding
C0Z11_RS02565	COG1716	ATPase activity
C0Z11_RS02570	COG1716	ATPase activity
C0Z11_RS02580	COG1088	dTDP-glucose 4,6-dehydratase activity
C0Z11_RS02585	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C0Z11_RS02600	COG3250	beta-galactosidase activity
C0Z11_RS02660	COG2801	Transposase and inactivated derivatives
C0Z11_RS02660	COG3415	Transposase
C0Z11_RS02675	COG1316	TRANSCRIPTIONal
C0Z11_RS02745	COG0489	protein tyrosine kinase activity
C0Z11_RS02755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0Z11_RS02780	COG0477	Major facilitator Superfamily
C0Z11_RS02785	COG1695	Transcriptional regulator
C0Z11_RS02790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0Z11_RS02840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C0Z11_RS02845	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0Z11_RS02865	COG0561	phosphatase activity
C0Z11_RS02870	COG0561	phosphatase activity
C0Z11_RS02875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0Z11_RS02920	COG2814	Major facilitator Superfamily
C0Z11_RS02935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C0Z11_RS02940	COG0148	phosphopyruvate hydratase activity
C0Z11_RS02950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0Z11_RS02955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0Z11_RS02960	COG0667	Aldo Keto reductase
C0Z11_RS02985	COG4581	dead DEAH box helicase
C0Z11_RS03000	COG0166	Belongs to the GPI family
C0Z11_RS03010	COG0444	Belongs to the ABC transporter superfamily
C0Z11_RS03015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0Z11_RS03020	COG0601	transmembrane transport
C0Z11_RS03025	COG0747	negative chemotaxis
C0Z11_RS03030	COG2949	membrane
C0Z11_RS03035	COG2814	Major facilitator Superfamily
C0Z11_RS03040	COG0656	L-ascorbic acid biosynthetic process
C0Z11_RS03045	COG0018	arginyl-trna synthetase
C0Z11_RS03055	COG3428	Bacterial PH domain
C0Z11_RS03065	COG1414	Transcriptional regulator
C0Z11_RS03075	COG3718	enzyme involved in inositol metabolism
C0Z11_RS03080	COG0673	inositol 2-dehydrogenase activity
C0Z11_RS03085	COG1082	Xylose isomerase domain protein TIM barrel
C0Z11_RS03090	COG2814	Major facilitator Superfamily
C0Z11_RS03100	COG0673	inositol 2-dehydrogenase activity
C0Z11_RS03105	COG0281	malic enzyme
C0Z11_RS03120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0Z11_RS03125	COG3959	Transketolase, thiamine diphosphate binding domain
C0Z11_RS03150	COG2188	Transcriptional regulator
C0Z11_RS03160	COG1609	Transcriptional regulator
C0Z11_RS03185	COG4608	Belongs to the ABC transporter superfamily
C0Z11_RS03220	COG0676	glucose-6-phosphate 1-epimerase activity
C0Z11_RS03225	COG3830	Belongs to the UPF0237 family
C0Z11_RS03225	COG0560	Phosphoserine phosphatase
C0Z11_RS03230	COG2813	Specifically methylates the guanine in position
C0Z11_RS03235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C0Z11_RS03240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0Z11_RS03240	COG0574	Belongs to the PEP-utilizing enzyme family
C0Z11_RS03255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C0Z11_RS03265	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C0Z11_RS03280	COG2205	protein histidine kinase activity
C0Z11_RS03285	COG0745	RESPONSE REGULATOR receiver
C0Z11_RS03310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C0Z11_RS03315	COG0484	heat shock protein binding
C0Z11_RS03320	COG0789	Transcriptional regulator
C0Z11_RS03330	COG3527	Alpha-acetolactate decarboxylase
C0Z11_RS03335	COG0569	domain protein
C0Z11_RS03335	COG2985	domain, Protein
C0Z11_RS03340	COG1113	amino acid transport
C0Z11_RS03345	COG0577	efflux transmembrane transporter activity
C0Z11_RS03345	COG1136	(ABC) transporter
C0Z11_RS03350	COG1136	(ABC) transporter
C0Z11_RS03350	COG4591	ABC-type transport system involved in lipoprotein release permease component
C0Z11_RS03360	COG2197	response regulator
C0Z11_RS03365	COG4585	Histidine kinase
C0Z11_RS03375	COG3588	fructose-bisphosphate aldolase
C0Z11_RS03390	COG0395	ABC-type sugar transport system, permease component
C0Z11_RS03400	COG0542	response to heat
C0Z11_RS03415	COG3158	transport of potassium into the cell
C0Z11_RS03430	COG3012	SEC-C Motif Domain Protein
C0Z11_RS03435	COG0076	glutamate decarboxylase activity
C0Z11_RS03440	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C0Z11_RS03450	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C0Z11_RS03465	COG3012	SEC-C Motif Domain Protein
C0Z11_RS03470	COG0517	IMP dehydrogenase activity
C0Z11_RS03470	COG4175	Glycine betaine
C0Z11_RS03475	COG4176	ABC-type proline glycine betaine transport system permease component
C0Z11_RS03500	COG1704	LemA family
C0Z11_RS03505	COG0586	Pfam SNARE associated Golgi protein
C0Z11_RS03520	COG0191	fructose-bisphosphate aldolase activity
C0Z11_RS03525	COG3739	integral membrane protein
C0Z11_RS03555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0Z11_RS03560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z11_RS03565	COG0588	phosphoglycerate mutase activity
C0Z11_RS03575	COG5002	protein histidine kinase activity
C0Z11_RS03590	COG1329	Transcriptional regulator
C0Z11_RS03605	COG3775	system Galactitol-specific IIC component
C0Z11_RS03615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C0Z11_RS03620	COG2390	Transcriptional regulator
C0Z11_RS03630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C0Z11_RS03635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C0Z11_RS03640	COG4948	Mandelate Racemase Muconate Lactonizing
C0Z11_RS03655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0Z11_RS03675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C0Z11_RS03680	COG2814	Major facilitator Superfamily
C0Z11_RS03685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0Z11_RS03690	COG0215	cysteine-tRNA ligase activity
C0Z11_RS03705	COG0626	cystathionine gamma-synthase activity
C0Z11_RS03715	COG3842	ATPase activity
C0Z11_RS03725	COG1760	l-serine dehydratase
C0Z11_RS03730	COG1063	alcohol dehydrogenase
C0Z11_RS03735	COG0156	8-amino-7-oxononanoate synthase activity
C0Z11_RS03740	COG3189	MarR family transcriptional regulator
C0Z11_RS03775	COG4585	Histidine kinase
C0Z11_RS03780	COG2197	response regulator
C0Z11_RS03785	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C0Z11_RS03790	COG1492	cobalamin metabolic process
C0Z11_RS03810	COG1648	precorrin-2 dehydrogenase activity
C0Z11_RS03810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0Z11_RS03825	COG1082	Xylose isomerase domain protein TIM barrel
C0Z11_RS03830	COG0673	inositol 2-dehydrogenase activity
C0Z11_RS03835	COG1082	Xylose isomerase domain protein TIM barrel
C0Z11_RS03840	COG1609	Transcriptional regulator
C0Z11_RS03845	COG2814	Major facilitator Superfamily
C0Z11_RS03875	COG0363	glucosamine-6-phosphate deaminase activity
C0Z11_RS03880	COG0390	transport system, permease component
C0Z11_RS03885	COG1278	Cold shock
C0Z11_RS03900	COG2252	PERMEase
C0Z11_RS03915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C0Z11_RS03925	COG1321	iron dependent repressor
C0Z11_RS03930	COG2226	methyltransferase
C0Z11_RS03935	COG3118	belongs to the thioredoxin family
C0Z11_RS03940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0Z11_RS03945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0Z11_RS03955	COG3718	enzyme involved in inositol metabolism
C0Z11_RS03960	COG3962	Belongs to the TPP enzyme family
C0Z11_RS03980	COG2814	Major facilitator Superfamily
C0Z11_RS03985	COG0673	inositol 2-dehydrogenase activity
C0Z11_RS04040	COG0628	permease
C0Z11_RS04055	COG0640	Transcriptional regulator
C0Z11_RS04065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0Z11_RS04070	COG0673	inositol 2-dehydrogenase activity
C0Z11_RS04115	COG0477	Major facilitator Superfamily
C0Z11_RS04125	COG0657	acetylesterase activity
C0Z11_RS04145	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C0Z11_RS04150	COG1984	allophanate hydrolase subunit 2
C0Z11_RS04155	COG0515	serine threonine protein kinase
C0Z11_RS04160	COG2233	PERMEase
C0Z11_RS04175	COG0084	hydrolase, TatD family'
C0Z11_RS04180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0Z11_RS04185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C0Z11_RS04190	COG1846	Transcriptional regulator
C0Z11_RS04205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0Z11_RS04210	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0Z11_RS04215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C0Z11_RS04220	COG0193	aminoacyl-tRNA hydrolase activity
C0Z11_RS04240	COG0148	phosphopyruvate hydratase activity
C0Z11_RS04285	COG0494	nUDIX hydrolase
C0Z11_RS04315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C0Z11_RS04320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C0Z11_RS04325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C0Z11_RS04330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0Z11_RS04340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0Z11_RS04345	COG0072	phenylalanine-tRNA ligase activity
C0Z11_RS04345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0Z11_RS04350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0Z11_RS04360	COG1438	arginine binding
C0Z11_RS04365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0Z11_RS04405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0Z11_RS04410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0Z11_RS04425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0Z11_RS04440	COG1331	Highly conserved protein containing a thioredoxin domain
C0Z11_RS04445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0Z11_RS04465	COG1722	exodeoxyribonuclease VII activity
C0Z11_RS04470	COG1570	exodeoxyribonuclease VII activity
C0Z11_RS04475	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C0Z11_RS04480	COG1322	Protein conserved in bacteria
C0Z11_RS04485	COG1362	aminopeptidase activity
C0Z11_RS04495	COG0012	GTP binding
C0Z11_RS04535	COG2161	toxin-antitoxin pair type II binding
C0Z11_RS04545	COG4115	mRNA cleavage
C0Z11_RS04560	COG1132	(ABC) transporter
C0Z11_RS04575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0Z11_RS04580	COG1335	isochorismatase
C0Z11_RS04600	COG0477	Major facilitator Superfamily
C0Z11_RS04635	COG2133	pyrroloquinoline quinone binding
C0Z11_RS04640	COG0667	Aldo Keto reductase
C0Z11_RS04675	COG2501	S4 domain
C0Z11_RS04685	COG0765	amino acid transport
C0Z11_RS04690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0Z11_RS04710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0Z11_RS04715	COG1121	(ABC) transporter
C0Z11_RS04745	COG4555	ABC transporter
C0Z11_RS04760	COG1012	belongs to the aldehyde dehydrogenase family
C0Z11_RS04765	COG1063	alcohol dehydrogenase
C0Z11_RS04770	COG2376	Dihydroxyacetone kinase
C0Z11_RS04780	COG1349	DNA-binding transcription factor activity
C0Z11_RS04785	COG0698	ribose 5-phosphate isomerase
C0Z11_RS04795	COG0647	UMP catabolic process
C0Z11_RS04805	COG0371	Dehydrogenase
C0Z11_RS04835	COG2814	Major facilitator Superfamily
C0Z11_RS04840	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C0Z11_RS04845	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C0Z11_RS04850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C0Z11_RS04880	COG2171	N-acyltransferase activity
C0Z11_RS04885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0Z11_RS04890	COG1611	Belongs to the LOG family
C0Z11_RS04905	COG0297	glycogen (starch) synthase activity
C0Z11_RS04910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C0Z11_RS04925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0Z11_RS04930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0Z11_RS04960	COG0006	proline dipeptidase activity
C0Z11_RS04970	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C0Z11_RS04975	COG0531	amino acid
C0Z11_RS04995	COG0598	Magnesium transport protein CorA
C0Z11_RS05010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0Z11_RS05015	COG0601	transmembrane transport
C0Z11_RS05070	COG0174	glutamine synthetase
C0Z11_RS05080	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C0Z11_RS05085	COG2966	Psort location CytoplasmicMembrane, score
C0Z11_RS05090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C0Z11_RS05095	COG0174	glutamine synthetase
C0Z11_RS05110	COG0438	transferase activity, transferring glycosyl groups
C0Z11_RS05120	COG0488	(ABC) transporter
C0Z11_RS05130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C0Z11_RS05145	COG0321	lipoyl(octanoyl) transferase activity
C0Z11_RS05190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C0Z11_RS05195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0Z11_RS05220	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C0Z11_RS05225	COG0723	plastoquinol--plastocyanin reductase activity
C0Z11_RS05230	COG2010	Cytochrome c
C0Z11_RS05235	COG1845	cytochrome c oxidase, subunit III
C0Z11_RS05245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0Z11_RS05285	COG3883	PFAM NLP P60 protein
C0Z11_RS05285	COG0791	NLP P60 protein
C0Z11_RS05290	COG1940	carbohydrate kinase activity
C0Z11_RS05315	COG2197	response regulator
C0Z11_RS05320	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C0Z11_RS05335	COG2815	serine threonine protein kinase
C0Z11_RS05335	COG0515	serine threonine protein kinase
C0Z11_RS05345	COG0142	geranyltranstransferase activity
C0Z11_RS05360	COG0210	DNA helicase
C0Z11_RS05380	COG1116	anion transmembrane transporter activity
C0Z11_RS05395	COG3265	gluconokinase activity
C0Z11_RS05405	COG1131	(ABC) transporter
C0Z11_RS05415	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0Z11_RS05415	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0Z11_RS05420	COG0509	glycine decarboxylation via glycine cleavage system
C0Z11_RS05425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C0Z11_RS05450	COG0714	Associated with various cellular activities
C0Z11_RS05455	COG2001	Belongs to the MraZ family
C0Z11_RS05460	COG0275	rRNA processing
C0Z11_RS05470	COG0768	penicillin binding
C0Z11_RS05480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C0Z11_RS05485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0Z11_RS05490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0Z11_RS05500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0Z11_RS05505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0Z11_RS05515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C0Z11_RS05520	COG1496	oxidoreductase activity
C0Z11_RS05525	COG1799	cell septum assembly
C0Z11_RS05545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0Z11_RS05555	COG0469	pyruvate kinase activity
C0Z11_RS05570	COG2050	protein possibly involved in aromatic compounds catabolism
C0Z11_RS05585	COG1280	lysine exporter protein (LysE YggA)
C0Z11_RS05605	COG0539	negative regulation of cytoplasmic translation
C0Z11_RS05610	COG0237	dephospho-CoA kinase activity
C0Z11_RS05615	COG0556	nucleotide-excision repair
C0Z11_RS05655	COG0322	excinuclease ABC activity
C0Z11_RS05660	COG1660	Displays ATPase and GTPase activities
C0Z11_RS05670	COG1481	regulation of sporulation
C0Z11_RS05675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0Z11_RS05680	COG0126	phosphoglycerate kinase activity
C0Z11_RS05685	COG0149	triose-phosphate isomerase activity
C0Z11_RS05690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0Z11_RS05700	COG0285	dihydrofolate synthase activity
C0Z11_RS05710	COG0105	UTP biosynthetic process
C0Z11_RS05715	COG1472	Belongs to the glycosyl hydrolase 3 family
C0Z11_RS05720	COG1530	ribonuclease E activity
C0Z11_RS05725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C0Z11_RS05730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C0Z11_RS05740	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0Z11_RS05745	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C0Z11_RS05750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C0Z11_RS05755	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C0Z11_RS05765	COG0406	alpha-ribazole phosphatase activity
C0Z11_RS05810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0Z11_RS05875	COG2217	Heavy metal translocating P-type atpase
C0Z11_RS05880	COG0366	Alpha amylase catalytic
C0Z11_RS05895	COG0495	leucyl-tRNA aminoacylation
C0Z11_RS05910	COG1061	Type III restriction enzyme res subunit
C0Z11_RS05920	COG0268	Binds directly to 16S ribosomal RNA
C0Z11_RS05925	COG0481	GTPase activity
C0Z11_RS05930	COG4948	Mandelate Racemase Muconate Lactonizing
C0Z11_RS05935	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C0Z11_RS05940	COG0488	(ABC) transporter
C0Z11_RS05945	COG1169	isochorismate synthase
C0Z11_RS05960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C0Z11_RS05970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0Z11_RS05975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0Z11_RS05985	COG1131	(ABC) transporter
C0Z11_RS05990	COG1309	transcriptional regulator
C0Z11_RS06000	COG0395	ABC-type sugar transport system, permease component
C0Z11_RS06005	COG1175	transmembrane transport
C0Z11_RS06025	COG0483	inositol monophosphate 1-phosphatase activity
C0Z11_RS06030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0Z11_RS06035	COG1420	regulation of RNA biosynthetic process
C0Z11_RS06040	COG0484	heat shock protein binding
C0Z11_RS06050	COG2259	Doxx family
C0Z11_RS06060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0Z11_RS06070	COG0343	queuine tRNA-ribosyltransferase activity
C0Z11_RS06075	COG4585	Histidine kinase
C0Z11_RS06080	COG2197	response regulator
C0Z11_RS06085	COG4152	abc transporter atp-binding protein
C0Z11_RS06090	COG1668	transmembrane transport
C0Z11_RS06115	COG2226	methyltransferase
C0Z11_RS06130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C0Z11_RS06140	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C0Z11_RS06150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0Z11_RS06155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0Z11_RS06160	COG0765	amino acid transport
C0Z11_RS06165	COG0765	amino acid transport
C0Z11_RS06175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0Z11_RS06180	COG0475	glutathione-regulated potassium exporter activity
C0Z11_RS06180	COG0569	domain protein
C0Z11_RS06185	COG1404	Belongs to the peptidase S8 family
C0Z11_RS06190	COG1381	Involved in DNA repair and RecF pathway recombination
C0Z11_RS06220	COG2801	Transposase and inactivated derivatives
C0Z11_RS06220	COG3415	Transposase
C0Z11_RS06240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0Z11_RS06280	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0Z11_RS06285	COG0798	PFAM Bile acid sodium symporter
C0Z11_RS06305	COG0735	belongs to the Fur family
C0Z11_RS06310	COG0423	glycine-tRNA ligase activity
C0Z11_RS06320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C0Z11_RS06325	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0Z11_RS06330	COG1051	belongs to the nudix hydrolase family
C0Z11_RS06335	COG0076	glutamate decarboxylase activity
C0Z11_RS06345	COG1053	succinate dehydrogenase
C0Z11_RS06365	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C0Z11_RS06370	COG0358	DNA primase activity
C0Z11_RS06390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0Z11_RS06395	COG0488	(ABC) transporter
C0Z11_RS06400	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C0Z11_RS06415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0Z11_RS06420	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C0Z11_RS06425	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C0Z11_RS06435	COG0583	DNA-binding transcription factor activity
C0Z11_RS06440	COG2818	Glycosylase
C0Z11_RS06445	COG0515	serine threonine protein kinase
C0Z11_RS06450	COG0515	serine threonine protein kinase
C0Z11_RS06480	COG0714	Associated with various cellular activities
C0Z11_RS06490	COG2304	oxidoreductase activity
C0Z11_RS06515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0Z11_RS06520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0Z11_RS06530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C0Z11_RS06545	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C0Z11_RS06555	COG0667	Aldo Keto reductase
C0Z11_RS06575	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C0Z11_RS06590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0Z11_RS06595	COG0543	2 iron, 2 sulfur cluster binding
C0Z11_RS06600	COG0167	dihydroorotate dehydrogenase activity
C0Z11_RS06605	COG0284	orotidine-5'-phosphate decarboxylase activity
C0Z11_RS06610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C0Z11_RS06620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0Z11_RS06630	COG1546	Belongs to the CinA family
C0Z11_RS06630	COG1058	Belongs to the CinA family
C0Z11_RS06640	COG1349	DNA-binding transcription factor activity
C0Z11_RS06655	COG2137	regulation of response to DNA damage stimulus
C0Z11_RS06660	COG1418	mRNA catabolic process
C0Z11_RS06665	COG2017	converts alpha-aldose to the beta-anomer
C0Z11_RS06670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0Z11_RS06680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C0Z11_RS06685	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C0Z11_RS06690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0Z11_RS06705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0Z11_RS06710	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0Z11_RS06715	COG0717	Belongs to the dCTP deaminase family
C0Z11_RS06740	COG1643	Atp-dependent helicase
C0Z11_RS06745	COG5426	von Willebrand factor, type A
C0Z11_RS06750	COG1946	Acyl-CoA thioesterase
C0Z11_RS06760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0Z11_RS06780	COG0187	DNA topoisomerase II activity
C0Z11_RS06800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C0Z11_RS06835	COG0756	dUTP diphosphatase activity
C0Z11_RS06860	COG0569	domain protein
C0Z11_RS06865	COG0531	amino acid
C0Z11_RS06870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0Z11_RS06880	COG2375	cellular response to nickel ion
C0Z11_RS06880	COG1132	(ABC) transporter
C0Z11_RS06915	COG1122	ATPase activity
C0Z11_RS06925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C0Z11_RS06930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0Z11_RS06945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0Z11_RS06980	COG0033	Phosphoglucomutase
C0Z11_RS06990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0Z11_RS07005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C0Z11_RS07010	COG0366	Alpha amylase catalytic
C0Z11_RS07025	COG2801	Transposase and inactivated derivatives
C0Z11_RS07025	COG3415	Transposase
C0Z11_RS07035	COG0482	sulfurtransferase activity
C0Z11_RS07050	COG1116	anion transmembrane transporter activity
C0Z11_RS07060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C0Z11_RS07075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0Z11_RS07080	COG0154	amidase activity
C0Z11_RS07085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0Z11_RS07090	COG2233	PERMEase
C0Z11_RS07105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0Z11_RS07110	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C0Z11_RS07125	COG0134	indole-3-glycerol-phosphate synthase activity
C0Z11_RS07130	COG0133	tryptophan synthase activity
C0Z11_RS07135	COG0159	tryptophan synthase activity
C0Z11_RS07140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C0Z11_RS07145	COG0070	glutamate synthase
C0Z11_RS07145	COG0067	glutamate synthase
C0Z11_RS07145	COG0069	glutamate synthase activity
C0Z11_RS07180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C0Z11_RS07185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0Z11_RS07190	COG0131	Imidazoleglycerol-phosphate dehydratase
C0Z11_RS07195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0Z11_RS07200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C0Z11_RS07205	COG0217	transcriptional regulatory protein
C0Z11_RS07210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C0Z11_RS07215	COG0632	four-way junction helicase activity
C0Z11_RS07220	COG2255	four-way junction helicase activity
C0Z11_RS07230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0Z11_RS07235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0Z11_RS07240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0Z11_RS07250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0Z11_RS07255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0Z11_RS07260	COG1196	nuclear chromosome segregation
C0Z11_RS07270	COG0124	histidyl-tRNA synthetase
C0Z11_RS07295	COG1309	transcriptional regulator
C0Z11_RS07305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0Z11_RS07335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0Z11_RS07340	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C0Z11_RS07345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0Z11_RS07350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C0Z11_RS07355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0Z11_RS07365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0Z11_RS07375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0Z11_RS07380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0Z11_RS07390	COG0194	GDP metabolic process
C0Z11_RS07395	COG1758	RNA polymerase activity
C0Z11_RS07405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C0Z11_RS07410	COG1201	RNA secondary structure unwinding
C0Z11_RS07415	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0Z11_RS07430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0Z11_RS07440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0Z11_RS07450	COG1410	methionine synthase
C0Z11_RS07450	COG0646	methionine synthase
C0Z11_RS07465	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C0Z11_RS07470	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
C0Z11_RS07480	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C0Z11_RS07495	COG1764	response to oxidative stress
C0Z11_RS07530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0Z11_RS07540	COG4221	oxidoreductase activity
C0Z11_RS07540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0Z11_RS07540	COG0604	alcohol dehydrogenase
C0Z11_RS07540	COG3321	synthase
C0Z11_RS07545	COG1151	hydroxylamine reductase activity
C0Z11_RS07550	COG0633	Ferredoxin
C0Z11_RS07550	COG0543	2 iron, 2 sulfur cluster binding
C0Z11_RS07590	COG0028	Belongs to the TPP enzyme family
C0Z11_RS07605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0Z11_RS07705	COG0561	phosphatase activity
C0Z11_RS07715	COG0427	acetyl-CoA hydrolase
C0Z11_RS07720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0Z11_RS07725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0Z11_RS07725	COG2813	Specifically methylates the guanine in position
C0Z11_RS07730	COG1522	sequence-specific DNA binding
C0Z11_RS07735	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C0Z11_RS07740	COG1216	Glycosyl transferase, family 2
C0Z11_RS07750	COG0584	glycerophosphoryl diester phosphodiesterase
C0Z11_RS07755	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C0Z11_RS07760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0Z11_RS07775	COG0531	amino acid
C0Z11_RS07820	COG1739	Uncharacterized protein family UPF0029
C0Z11_RS07825	COG1472	Belongs to the glycosyl hydrolase 3 family
C0Z11_RS07830	COG1597	lipid kinase activity
C0Z11_RS07835	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C0Z11_RS07840	COG0009	L-threonylcarbamoyladenylate synthase
C0Z11_RS07850	COG0205	6-phosphofructokinase activity
C0Z11_RS07855	COG1295	ribonuclease BN
C0Z11_RS07875	COG1716	ATPase activity
C0Z11_RS07880	COG0509	glycine decarboxylation via glycine cleavage system
C0Z11_RS07900	COG0438	transferase activity, transferring glycosyl groups
C0Z11_RS07905	COG1560	Kdo2-lipid A biosynthetic process
C0Z11_RS07910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0Z11_RS07920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C0Z11_RS07980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C0Z11_RS07985	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0Z11_RS07990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C0Z11_RS07995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C0Z11_RS08000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0Z11_RS08005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C0Z11_RS08015	COG0356	it plays a direct role in the translocation of protons across the membrane
C0Z11_RS08035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0Z11_RS08040	COG0367	asparagine synthase
C0Z11_RS08045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0Z11_RS08050	COG0736	holo-[acyl-carrier-protein] synthase activity
C0Z11_RS08060	COG0318	PFAM AMP-dependent synthetase and ligase
C0Z11_RS08120	COG2244	polysaccharide biosynthetic process
C0Z11_RS08130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0Z11_RS08140	COG2890	protein-(glutamine-N5) methyltransferase activity
C0Z11_RS08145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0Z11_RS08150	COG0254	rRNA binding
C0Z11_RS08160	COG0083	homoserine kinase activity
C0Z11_RS08165	COG0460	homoserine dehydrogenase
C0Z11_RS08170	COG0019	diaminopimelate decarboxylase activity
C0Z11_RS08180	COG1611	Belongs to the LOG family
C0Z11_RS08190	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0Z11_RS08190	COG0567	Dehydrogenase, E1 component
C0Z11_RS08215	COG1595	DNA-templated transcription, initiation
C0Z11_RS08225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0Z11_RS08230	COG1162	GTPase activity
C0Z11_RS08240	COG0483	inositol monophosphate 1-phosphatase activity
C0Z11_RS08245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0Z11_RS08250	COG4608	Belongs to the ABC transporter superfamily
C0Z11_RS08260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0Z11_RS08290	COG1472	Belongs to the glycosyl hydrolase 3 family
C0Z11_RS08295	COG1615	UPF0182 protein
C0Z11_RS08305	COG3480	Lon protease (S16) C-terminal proteolytic domain
C0Z11_RS08330	COG1074	ATP-dependent DNA helicase activity
C0Z11_RS08355	COG1074	ATP-dependent DNA helicase activity
C0Z11_RS08390	COG0180	Tryptophanyl-tRNA synthetase
C0Z11_RS08400	COG2902	Dehydrogenase
C0Z11_RS08420	COG0653	protein targeting
C0Z11_RS08430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C0Z11_RS08440	COG5401	PFAM Sporulation and spore germination
C0Z11_RS08445	COG5002	protein histidine kinase activity
C0Z11_RS08445	COG5000	phosphorelay sensor kinase activity
C0Z11_RS08450	COG0745	RESPONSE REGULATOR receiver
C0Z11_RS08455	COG1678	Uncharacterized ACR, COG1678
C0Z11_RS08535	COG0165	Argininosuccinate lyase
C0Z11_RS08545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0Z11_RS08550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0Z11_RS08555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C0Z11_RS08560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C0Z11_RS08565	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C0Z11_RS08575	COG2884	Cell division ATP-binding protein ftsE
C0Z11_RS08580	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C0Z11_RS08600	COG1674	ftsk spoiiie
C0Z11_RS08620	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0Z11_RS08630	COG0066	3-isopropylmalate dehydratase activity
C0Z11_RS08635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0Z11_RS08640	COG1414	Transcriptional regulator
C0Z11_RS08655	COG1266	CAAX protease self-immunity
C0Z11_RS08660	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0Z11_RS08670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0Z11_RS08675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0Z11_RS08680	COG0473	3-isopropylmalate dehydrogenase activity
C0Z11_RS08690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C0Z11_RS08695	COG0440	acetolactate synthase activity
C0Z11_RS08705	COG0537	adenosine 5'-monophosphoramidase activity
C0Z11_RS08710	COG0107	imidazoleglycerol-phosphate synthase activity
C0Z11_RS08715	COG4581	dead DEAH box helicase
C0Z11_RS08740	COG2378	regulation of single-species biofilm formation
C0Z11_RS08750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0Z11_RS08775	COG4974	Belongs to the 'phage' integrase family
C0Z11_RS08780	COG0494	nUDIX hydrolase
C0Z11_RS08785	COG0504	CTP synthase activity
C0Z11_RS08790	COG0497	DNA recombination
C0Z11_RS08795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0Z11_RS08805	COG1122	ATPase activity
C0Z11_RS08810	COG1268	BioY protein
C0Z11_RS08815	COG0647	UMP catabolic process
C0Z11_RS08850	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C0Z11_RS08855	COG0140	phosphoribosyl-ATP diphosphatase activity
C0Z11_RS08860	COG3201	nicotinamide mononucleotide transporter
C0Z11_RS08870	COG0667	Aldo Keto reductase
C0Z11_RS08880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0Z11_RS08935	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0Z11_RS08940	COG1937	Protein conserved in bacteria
C0Z11_RS08945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0Z11_RS08960	COG0745	RESPONSE REGULATOR receiver
C0Z11_RS08965	COG1968	undecaprenyl-diphosphatase activity
C0Z11_RS08970	COG0671	phosphoesterase, PA-phosphatase related
C0Z11_RS08975	COG0390	transport system, permease component
C0Z11_RS09065	COG0792	nuclease activity
C0Z11_RS09075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0Z11_RS09080	COG0681	Belongs to the peptidase S26 family
C0Z11_RS09085	COG0335	large ribosomal subunit rRNA binding
C0Z11_RS09095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0Z11_RS09100	COG1053	succinate dehydrogenase
C0Z11_RS09110	COG0336	Belongs to the RNA methyltransferase TrmD family
C0Z11_RS09115	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0Z11_RS09120	COG1837	Belongs to the UPF0109 family
C0Z11_RS09125	COG0228	four-way junction DNA binding
C0Z11_RS09155	COG2076	Multidrug Resistance protein
C0Z11_RS09180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0Z11_RS09185	COG0571	ribonuclease III activity
C0Z11_RS09190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C0Z11_RS09200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C0Z11_RS09205	COG0742	ribosomal rna small subunit methyltransferase
C0Z11_RS09215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0Z11_RS09220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C0Z11_RS09225	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C0Z11_RS09235	COG0028	Belongs to the TPP enzyme family
C0Z11_RS09245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C0Z11_RS09265	COG1185	polyribonucleotide nucleotidyltransferase activity
C0Z11_RS09285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0Z11_RS09290	COG0196	riboflavin kinase activity
C0Z11_RS09295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0Z11_RS09300	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0Z11_RS09305	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C0Z11_RS09320	COG0779	Required for maturation of 30S ribosomal subunits
C0Z11_RS09335	COG0442	prolyl-tRNA aminoacylation
C0Z11_RS09340	COG1305	Transglutaminase-like
C0Z11_RS09360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C0Z11_RS09365	COG0750	zinc metalloprotease
C0Z11_RS09370	COG0387	Pfam Sodium calcium exchanger
C0Z11_RS09375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0Z11_RS09380	COG0575	Belongs to the CDS family
C0Z11_RS09385	COG0233	cytoplasmic translational termination
C0Z11_RS09390	COG0528	UMP kinase activity
C0Z11_RS09395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C0Z11_RS09400	COG0052	Belongs to the universal ribosomal protein uS2 family
C0Z11_RS09410	COG4974	Belongs to the 'phage' integrase family
C0Z11_RS09420	COG0242	peptide deformylase activity
C0Z11_RS09445	COG1119	ATPase activity
C0Z11_RS09450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C0Z11_RS09495	COG0488	(ABC) transporter
C0Z11_RS09525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0Z11_RS09530	COG0396	ATPase activity
C0Z11_RS09545	COG0719	Fe-S assembly protein
C0Z11_RS09560	COG1175	transmembrane transport
C0Z11_RS09565	COG3833	ABC-type maltose transport systems, permease component
C0Z11_RS09570	COG1609	Transcriptional regulator
C0Z11_RS09575	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C0Z11_RS09590	COG1612	heme a metabolic process
C0Z11_RS09600	COG0109	protoheme IX farnesyltransferase activity
C0Z11_RS09615	COG0363	glucosamine-6-phosphate deaminase activity
C0Z11_RS09625	COG0525	valine-tRNA ligase activity
C0Z11_RS09645	COG0793	Belongs to the peptidase S41A family
C0Z11_RS09645	COG4946	Tricorn protease homolog
C0Z11_RS09650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C0Z11_RS09655	COG0740	serine-type endopeptidase activity
C0Z11_RS09660	COG0740	serine-type endopeptidase activity
C0Z11_RS09670	COG0544	peptidyl-prolyl cis-trans isomerase activity
C0Z11_RS09690	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C0Z11_RS09690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C0Z11_RS09710	COG0698	ribose 5-phosphate isomerase
C0Z11_RS09725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0Z11_RS09730	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0Z11_RS09745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C0Z11_RS09765	COG1022	Amp-dependent synthetase and ligase
C0Z11_RS09780	COG0247	lactate metabolic process
C0Z11_RS09780	COG0277	FAD linked oxidase domain protein
C0Z11_RS09815	COG2235	arginine
C0Z11_RS09820	COG1757	Na H antiporter
C0Z11_RS09850	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C0Z11_RS09915	COG3145	DNA-N1-methyladenine dioxygenase activity
C0Z11_RS09920	COG2801	Transposase and inactivated derivatives
C0Z11_RS09930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0Z11_RS09990	COG1305	Transglutaminase-like
C0Z11_RS10030	COG0604	alcohol dehydrogenase
C0Z11_RS10040	COG1914	H( )-stimulated, divalent metal cation uptake system
C0Z11_RS10045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0Z11_RS10045	COG1321	iron dependent repressor
C0Z11_RS10050	COG1113	amino acid transport
C0Z11_RS10065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0Z11_RS10070	COG0531	amino acid
C0Z11_RS10115	COG0587	DNA-directed DNA polymerase activity
C0Z11_RS10130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0Z11_RS10165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C0Z11_RS10185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0Z11_RS10190	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C0Z11_RS10195	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C0Z11_RS10200	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C0Z11_RS10205	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0Z11_RS10210	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C0Z11_RS10220	COG1918	ferrous iron import across plasma membrane
C0Z11_RS10220	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C0Z11_RS10235	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C0Z11_RS10265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C0Z11_RS10270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C0Z11_RS10330	COG1316	TRANSCRIPTIONal
C0Z11_RS10350	COG3340	Belongs to the peptidase S51 family
C0Z11_RS10355	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C0Z11_RS10355	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C0Z11_RS10360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0Z11_RS10370	COG0424	maF-like protein
C0Z11_RS10380	COG2235	arginine
C0Z11_RS10385	COG4221	oxidoreductase activity
C0Z11_RS10390	COG0351	phosphomethylpyrimidine kinase
C0Z11_RS10405	COG4770	biotin carboxylase activity
C0Z11_RS10420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0Z11_RS10425	COG0318	PFAM AMP-dependent synthetase and ligase
C0Z11_RS10440	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0Z11_RS10445	COG0328	RNA-DNA hybrid ribonuclease activity
C0Z11_RS10455	COG1079	Belongs to the binding-protein-dependent transport system permease family
C0Z11_RS10460	COG4603	Belongs to the binding-protein-dependent transport system permease family
C0Z11_RS10465	COG3845	ABC transporter
C0Z11_RS10470	COG1744	ABC transporter substrate-binding protein PnrA-like
C0Z11_RS10480	COG1253	flavin adenine dinucleotide binding
C0Z11_RS10495	COG0039	L-malate dehydrogenase activity
C0Z11_RS10505	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0Z11_RS10520	COG0138	bifunctional purine biosynthesis protein purh
C0Z11_RS10530	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C0Z11_RS10535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0Z11_RS10535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0Z11_RS10565	COG0045	succinate-CoA ligase (ADP-forming) activity
C0Z11_RS10580	COG1464	Belongs to the NlpA lipoprotein family
C0Z11_RS10585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0Z11_RS10590	COG2011	ABC-type metal ion transport system permease component
C0Z11_RS10595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0Z11_RS10600	COG2261	transglycosylase associated protein
C0Z11_RS10605	COG2197	response regulator
C0Z11_RS10630	COG0519	Catalyzes the synthesis of GMP from XMP
C0Z11_RS10630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0Z11_RS10635	COG1045	serine acetyltransferase
C0Z11_RS10640	COG0287	Prephenate dehydrogenase
C0Z11_RS10640	COG1605	Chorismate mutase
C0Z11_RS10655	COG0516	GMP reductase activity
C0Z11_RS10670	COG0459	protein refolding
C0Z11_RS10675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C0Z11_RS10720	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C0Z11_RS10725	COG0456	acetyltransferase
C0Z11_RS10730	COG0456	acetyltransferase
C0Z11_RS10730	COG1214	PFAM Peptidase M22, glycoprotease
C0Z11_RS10735	COG0802	atpase or kinase
C0Z11_RS10740	COG0513	Belongs to the DEAD box helicase family
C0Z11_RS10750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0Z11_RS10750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C0Z11_RS10760	COG1175	transmembrane transport
C0Z11_RS10765	COG0395	ABC-type sugar transport system, permease component
C0Z11_RS10775	COG1846	Transcriptional regulator
C0Z11_RS10775	COG1940	carbohydrate kinase activity
C0Z11_RS10780	COG0736	holo-[acyl-carrier-protein] synthase activity
C0Z11_RS10785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0Z11_RS10790	COG2264	protein methyltransferase activity
C0Z11_RS10795	COG1072	(Pantothenic acid kinase))
C0Z11_RS10805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0Z11_RS10810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0Z11_RS10815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C0Z11_RS10820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0Z11_RS10825	COG0101	tRNA pseudouridine synthase activity
C0Z11_RS10845	COG3845	ABC transporter
C0Z11_RS10870	COG0438	transferase activity, transferring glycosyl groups
C0Z11_RS10875	COG0203	ribosomal protein L17
C0Z11_RS10880	COG0202	RNA polymerase activity
C0Z11_RS10885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0Z11_RS10890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C0Z11_RS10895	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C0Z11_RS10905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C0Z11_RS10910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C0Z11_RS10930	COG0563	adenylate kinase activity
C0Z11_RS10970	COG0200	Binds to the 23S rRNA
C0Z11_RS10975	COG1841	ribosomal large subunit assembly
C0Z11_RS10980	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C0Z11_RS10985	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C0Z11_RS10990	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C0Z11_RS10995	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C0Z11_RS11000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C0Z11_RS11005	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C0Z11_RS11010	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C0Z11_RS11015	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C0Z11_RS11045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C0Z11_RS11050	COG0255	Belongs to the universal ribosomal protein uL29 family
C0Z11_RS11055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C0Z11_RS11060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C0Z11_RS11065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C0Z11_RS11070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C0Z11_RS11075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C0Z11_RS11080	COG0089	rRNA binding
C0Z11_RS11085	COG0088	Forms part of the polypeptide exit tunnel
C0Z11_RS11090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C0Z11_RS11095	COG0051	transcription antitermination factor activity, RNA binding
C0Z11_RS11100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0Z11_RS11105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0Z11_RS11110	COG0737	Belongs to the 5'-nucleotidase family
C0Z11_RS11125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0Z11_RS11130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C0Z11_RS11135	COG0049	tRNA binding
C0Z11_RS11140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0Z11_RS11145	COG0673	inositol 2-dehydrogenase activity
C0Z11_RS11155	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0Z11_RS11160	COG0085	RNA polymerase activity
C0Z11_RS11165	COG0222	ribosome binding
C0Z11_RS11170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C0Z11_RS11175	COG0081	regulation of translation
C0Z11_RS11180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0Z11_RS11185	COG0250	Participates in transcription elongation, termination and antitermination
C0Z11_RS11200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0Z11_RS11205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C0Z11_RS11215	COG2030	dehydratase
C0Z11_RS11220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0Z11_RS11245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0Z11_RS11250	COG0708	Exodeoxyribonuclease III
C0Z11_RS11255	COG1024	Enoyl-CoA hydratase
C0Z11_RS11265	COG0674	pyruvate-flavodoxin oxidoreductase activity
C0Z11_RS11265	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C0Z11_RS11270	COG1013	pyruvate-flavodoxin oxidoreductase activity
C0Z11_RS11280	COG3590	peptidase
C0Z11_RS11285	COG2301	Belongs to the HpcH HpaI aldolase family
C0Z11_RS11300	COG0142	geranyltranstransferase activity
C0Z11_RS11305	COG1007	ATP synthesis coupled electron transport
C0Z11_RS11320	COG0713	ATP synthesis coupled electron transport
C0Z11_RS11330	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0Z11_RS11335	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C0Z11_RS11340	COG1034	ATP synthesis coupled electron transport
C0Z11_RS11345	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C0Z11_RS11355	COG0649	NAD binding
C0Z11_RS11360	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0Z11_RS11365	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0Z11_RS11400	COG2226	methyltransferase
C0Z11_RS11410	COG1132	(ABC) transporter
C0Z11_RS11415	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C0Z11_RS11425	COG2814	Major facilitator Superfamily
C0Z11_RS11430	COG2376	Dihydroxyacetone kinase
C0Z11_RS11435	COG1461	Dihydroxyacetone kinase
C0Z11_RS11440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0Z11_RS11440	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C0Z11_RS11440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0Z11_RS11460	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C0Z11_RS11480	COG0531	amino acid
C0Z11_RS11485	COG1834	amidinotransferase
C0Z11_RS11490	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C0Z11_RS11520	COG4133	protoheme IX ABC transporter activity
C0Z11_RS11590	COG0395	ABC-type sugar transport system, permease component
C0Z11_RS11595	COG1175	transmembrane transport
C0Z11_RS11615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0Z11_RS11620	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C0Z11_RS11630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0Z11_RS11650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0Z11_RS11670	COG0252	asparaginase activity
C0Z11_RS11675	COG1113	amino acid transport
C0Z11_RS11680	COG0047	phosphoribosylformylglycinamidine synthase activity
C0Z11_RS11685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0Z11_RS11700	COG0583	DNA-binding transcription factor activity
C0Z11_RS11705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0Z11_RS11715	COG0697	spore germination
C0Z11_RS11720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C0Z11_RS11735	COG1937	Protein conserved in bacteria
C0Z11_RS11740	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0Z11_RS11750	COG2337	Toxic component of a toxin-antitoxin (TA) module
C0Z11_RS11785	COG3118	belongs to the thioredoxin family
C0Z11_RS11790	COG0492	ferredoxin-NADP+ reductase activity
C0Z11_RS11810	COG2094	Belongs to the DNA glycosylase MPG family
C0Z11_RS11820	COG1643	Atp-dependent helicase
C0Z11_RS11835	COG2897	thiosulfate sulfurtransferase activity
C0Z11_RS11865	COG0438	transferase activity, transferring glycosyl groups
C0Z11_RS11875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C0Z11_RS11880	COG1126	abc transporter atp-binding protein
C0Z11_RS11885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0Z11_RS11890	COG0765	amino acid transport
C0Z11_RS11895	COG0765	amino acid transport
C0Z11_RS11930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0Z11_RS11970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0Z11_RS12005	COG1309	transcriptional regulator
C0Z11_RS12015	COG2130	NADP-dependent
C0Z11_RS12020	COG2801	Transposase and inactivated derivatives
C0Z11_RS12045	COG1063	alcohol dehydrogenase
C0Z11_RS12065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0Z11_RS12115	COG1660	Displays ATPase and GTPase activities
C0Z11_RS12135	COG2124	cytochrome p450
C0Z11_RS12150	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C0Z11_RS12160	COG0142	geranyltranstransferase activity
C0Z11_RS12175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C0Z11_RS12200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C0Z11_RS12205	COG2176	DNA-directed DNA polymerase activity
C0Z11_RS12205	COG5002	protein histidine kinase activity
C0Z11_RS12225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0Z11_RS12245	COG0686	Belongs to the AlaDH PNT family
C0Z11_RS12250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0Z11_RS12260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0Z11_RS12280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0Z11_RS12285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C0Z11_RS12295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0Z11_RS12300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0Z11_RS12310	COG2070	2-Nitropropane dioxygenase
C0Z11_RS12310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C0Z11_RS12325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0Z11_RS12365	COG1201	RNA secondary structure unwinding
C0Z11_RS12380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0Z11_RS12395	COG1401	restriction endodeoxyribonuclease activity
C0Z11_RS12405	COG1401	restriction endodeoxyribonuclease activity
C0Z11_RS12415	COG3876	Protein conserved in bacteria
C0Z11_RS12420	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C0Z11_RS12420	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C0Z11_RS12430	COG1486	melibiose metabolic process
C0Z11_RS12435	COG2326	polyphosphate kinase activity
C0Z11_RS12445	COG0395	ABC-type sugar transport system, permease component
C0Z11_RS12450	COG1653	transport
C0Z11_RS12455	COG0584	glycerophosphoryl diester phosphodiesterase
C0Z11_RS12460	COG1609	Transcriptional regulator
C0Z11_RS12470	COG1285	pathogenesis
C0Z11_RS12485	COG0110	maltose O-acetyltransferase activity
C0Z11_RS12490	COG3226	Transcriptional regulator
C0Z11_RS12515	COG1175	transmembrane transport
C0Z11_RS12520	COG1285	pathogenesis
C0Z11_RS12525	COG1609	Transcriptional regulator
C0Z11_RS12540	COG2801	Transposase and inactivated derivatives
C0Z11_RS12550	COG2801	Transposase and inactivated derivatives
C0Z11_RS12580	COG0640	Transcriptional regulator
C0Z11_RS12585	COG2066	Belongs to the glutaminase family
C0Z11_RS12605	COG3386	PFAM SMP-30 Gluconolaconase
C0Z11_RS12610	COG0753	catalase activity
C0Z11_RS12610	COG0693	protein deglycase activity
C0Z11_RS12630	COG1028	Short-chain dehydrogenase reductase Sdr
C0Z11_RS12660	COG2261	transglycosylase associated protein
C0Z11_RS12665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C0Z11_RS12670	COG0477	Major facilitator Superfamily
C0Z11_RS12690	COG2261	transglycosylase associated protein
C0Z11_RS12695	COG3959	Transketolase, thiamine diphosphate binding domain
C0Z11_RS12700	COG0352	thiamine-phosphate diphosphorylase activity
C0Z11_RS12710	COG0477	Major facilitator Superfamily
C0Z11_RS12715	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C0Z11_RS12715	COG0351	phosphomethylpyrimidine kinase
C0Z11_RS12715	COG0352	thiamine-phosphate diphosphorylase activity
C0Z11_RS12720	COG1968	undecaprenyl-diphosphatase activity
C0Z11_RS12725	COG0359	binds to the 23S rRNA
C0Z11_RS12730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C0Z11_RS12735	COG0629	single-stranded DNA binding
C0Z11_RS12740	COG0360	Binds together with S18 to 16S ribosomal RNA
C0Z11_RS12745	COG2837	iron assimilation
C0Z11_RS12750	COG2822	iron ion transport
C0Z11_RS12755	COG0672	)-iron permease
C0Z11_RS12765	COG1022	Amp-dependent synthetase and ligase
C0Z11_RS12775	COG0300	oxidoreductase activity
C0Z11_RS12815	COG0277	FAD linked oxidase domain protein
C0Z11_RS12825	COG2197	response regulator
C0Z11_RS12830	COG1131	(ABC) transporter
C0Z11_RS12840	COG4585	Histidine kinase
C0Z11_RS12855	COG1136	(ABC) transporter
C0Z11_RS12860	COG0247	lactate metabolic process
C0Z11_RS12865	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C0Z11_RS12870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C0Z11_RS12935	COG3415	Transposase
C0Z11_RS12935	COG2801	Transposase and inactivated derivatives
C0Z11_RS12955	COG0534	Mate efflux family protein
C0Z11_RS12965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0Z11_RS12985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C0Z11_RS13010	COG2391	methyltransferase activity
C0Z11_RS13015	COG0425	Belongs to the sulfur carrier protein TusA family
C0Z11_RS13020	COG1131	(ABC) transporter
C0Z11_RS13020	COG1716	ATPase activity
C0Z11_RS13020	COG0842	Transport permease protein
C0Z11_RS13025	COG0515	serine threonine protein kinase
C0Z11_RS13035	COG0205	6-phosphofructokinase activity
C0Z11_RS13040	COG2267	carboxylic ester hydrolase activity
C0Z11_RS13065	COG3842	ATPase activity
C0Z11_RS13070	COG2271	Major facilitator Superfamily
C0Z11_RS13085	COG1376	ErfK ybiS ycfS ynhG family protein
C0Z11_RS13090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C0Z11_RS13120	COG2848	UPF0210 protein
C0Z11_RS13125	COG3830	Belongs to the UPF0237 family
C0Z11_RS13135	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C0Z11_RS13150	COG0668	transmembrane transport
C0Z11_RS13155	COG1929	Belongs to the glycerate kinase type-1 family
C0Z11_RS13160	COG0617	tRNA 3'-terminal CCA addition
C0Z11_RS13180	COG1595	DNA-templated transcription, initiation
C0Z11_RS13190	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C0Z11_RS13195	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C0Z11_RS13200	COG2390	Transcriptional regulator
C0Z11_RS13205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0Z11_RS13250	COG2066	Belongs to the glutaminase family
C0Z11_RS13270	COG4585	Histidine kinase
C0Z11_RS13280	COG1082	Xylose isomerase domain protein TIM barrel
C0Z11_RS13295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0Z11_RS13300	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0Z11_RS13310	COG0519	Catalyzes the synthesis of GMP from XMP
C0Z11_RS13310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0Z11_RS13320	COG3415	Transposase
C0Z11_RS13320	COG2801	Transposase and inactivated derivatives
C0Z11_RS13325	COG1475	DNA binding
C0Z11_RS13330	COG1192	Involved in chromosome partitioning
C0Z11_RS13335	COG0357	Ribosomal RNA small subunit methyltransferase G
C0Z11_RS13345	COG0706	membrane insertase activity
C0Z11_RS13355	COG0594	ribonuclease P activity
C0Z11_RS13360	COG0230	Belongs to the bacterial ribosomal protein bL34 family