locus-tag	class	description
JS278_RS00010	COG0577	efflux transmembrane transporter activity
JS278_RS00010	COG1136	(ABC) transporter
JS278_RS00015	COG0577	efflux transmembrane transporter activity
JS278_RS00020	COG0592	DNA-directed DNA polymerase activity
JS278_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JS278_RS00035	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
JS278_RS00045	COG0187	DNA topoisomerase II activity
JS278_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JS278_RS00065	COG1609	Transcriptional regulator
JS278_RS00070	COG1129	ABC transporter
JS278_RS00075	COG1172	Belongs to the binding-protein-dependent transport system permease family
JS278_RS00085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS278_RS00090	COG1869	D-ribose catabolic process
JS278_RS00115	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_RS00130	COG1396	sequence-specific DNA binding
JS278_RS00135	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
JS278_RS00175	COG0281	malic enzyme
JS278_RS00180	COG0039	L-malate dehydrogenase activity
JS278_RS00185	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JS278_RS00205	COG4106	trans-aconitate 2-methyltransferase activity
JS278_RS00210	COG4106	trans-aconitate 2-methyltransferase activity
JS278_RS00220	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JS278_RS00225	COG4139	cobalamin transport
JS278_RS00230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JS278_RS00235	COG2197	response regulator
JS278_RS00250	COG0436	Aminotransferase
JS278_RS00265	COG0235	Class ii aldolase
JS278_RS00275	COG1063	alcohol dehydrogenase
JS278_RS00280	COG3414	Phosphotransferase system galactitol-specific IIB component
JS278_RS00285	COG3775	system Galactitol-specific IIC component
JS278_RS00300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JS278_RS00315	COG1131	(ABC) transporter
JS278_RS00325	COG0095	Lipoate-protein ligase
JS278_RS00330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JS278_RS00335	COG0765	amino acid transport
JS278_RS00340	COG1126	abc transporter atp-binding protein
JS278_RS00345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JS278_RS00355	COG1653	transport
JS278_RS00360	COG1175	transmembrane transport
JS278_RS00365	COG0395	ABC-type sugar transport system, permease component
JS278_RS00445	COG1012	belongs to the aldehyde dehydrogenase family
JS278_RS00485	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JS278_RS00510	COG2177	Part of the ABC transporter FtsEX involved in
JS278_RS00515	COG0577	efflux transmembrane transporter activity
JS278_RS00515	COG1136	(ABC) transporter
JS278_RS00520	COG2197	response regulator
JS278_RS00525	COG1690	Belongs to the RtcB family
JS278_RS00540	COG0477	Major facilitator Superfamily
JS278_RS00545	COG2826	transposase and inactivated derivatives, IS30 family
JS278_RS00560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JS278_RS00570	COG2205	protein histidine kinase activity
JS278_RS00575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JS278_RS00580	COG4585	Histidine kinase
JS278_RS00600	COG0175	sulfate reduction
JS278_RS00615	COG0730	response to heat
JS278_RS00640	COG1473	amidohydrolase
JS278_RS00650	COG0656	L-ascorbic acid biosynthetic process
JS278_RS00655	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JS278_RS00660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JS278_RS00660	COG0596	Alpha beta hydrolase
JS278_RS00670	COG2022	thiamine diphosphate biosynthetic process
JS278_RS00685	COG1428	Deoxynucleoside kinase
JS278_RS00690	COG1309	transcriptional regulator
JS278_RS00695	COG2409	Drug exporters of the RND superfamily
JS278_RS00705	COG2910	NAD(P)H-binding
JS278_RS00710	COG1733	regulation of RNA biosynthetic process
JS278_RS00715	COG3118	belongs to the thioredoxin family
JS278_RS00715	COG0492	ferredoxin-NADP+ reductase activity
JS278_RS00725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JS278_RS00735	COG2390	Transcriptional regulator
JS278_RS00740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JS278_RS00745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JS278_RS00760	COG1595	DNA-templated transcription, initiation
JS278_RS00765	COG2815	serine threonine protein kinase
JS278_RS00765	COG0515	serine threonine protein kinase
JS278_RS00785	COG0385	Bile acid
JS278_RS00790	COG1012	belongs to the aldehyde dehydrogenase family
JS278_RS00795	COG0617	tRNA 3'-terminal CCA addition
JS278_RS00800	COG1929	Belongs to the glycerate kinase type-1 family
JS278_RS00810	COG0668	transmembrane transport
JS278_RS00820	COG0540	Belongs to the ATCase OTCase family
JS278_RS00840	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JS278_RS00850	COG0114	fumarate hydratase activity
JS278_RS00900	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JS278_RS00925	COG0745	RESPONSE REGULATOR receiver
JS278_RS00940	COG2205	protein histidine kinase activity
JS278_RS00945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JS278_RS00955	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JS278_RS00960	COG1376	ErfK ybiS ycfS ynhG family protein
JS278_RS00995	COG2267	carboxylic ester hydrolase activity
JS278_RS01000	COG0686	Belongs to the AlaDH PNT family
JS278_RS01005	COG0205	6-phosphofructokinase activity
JS278_RS01010	COG1012	belongs to the aldehyde dehydrogenase family
JS278_RS01025	COG0515	serine threonine protein kinase
JS278_RS01030	COG0842	Transport permease protein
JS278_RS01030	COG1716	ATPase activity
JS278_RS01030	COG1131	(ABC) transporter
JS278_RS01035	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JS278_RS01035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JS278_RS01045	COG2002	toxin-antitoxin pair type II binding
JS278_RS01050	COG3609	addiction module antidote protein, CC2985 family
JS278_RS01055	COG2337	Toxic component of a toxin-antitoxin (TA) module
JS278_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_RS01095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JS278_RS01100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JS278_RS01120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JS278_RS01125	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JS278_RS01140	COG1609	Transcriptional regulator
JS278_RS01150	COG1175	transmembrane transport
JS278_RS01160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JS278_RS01165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS278_RS01265	COG1113	amino acid transport
JS278_RS01280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JS278_RS01300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JS278_RS01315	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JS278_RS01320	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
JS278_RS01325	COG0247	lactate metabolic process
JS278_RS01335	COG1126	abc transporter atp-binding protein
JS278_RS01365	COG1131	(ABC) transporter
JS278_RS01370	COG2197	response regulator
JS278_RS01375	COG4585	Histidine kinase
JS278_RS01395	COG0277	FAD linked oxidase domain protein
JS278_RS01440	COG0300	oxidoreductase activity
JS278_RS01450	COG1022	Amp-dependent synthetase and ligase
JS278_RS01480	COG0672	)-iron permease
JS278_RS01490	COG2837	iron assimilation
JS278_RS01495	COG0360	Binds together with S18 to 16S ribosomal RNA
JS278_RS01505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JS278_RS01510	COG0359	binds to the 23S rRNA
JS278_RS01520	COG1968	undecaprenyl-diphosphatase activity
JS278_RS01530	COG1902	pentaerythritol trinitrate reductase activity
JS278_RS01555	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JS278_RS01565	COG2205	protein histidine kinase activity
JS278_RS01585	COG1132	(ABC) transporter
JS278_RS01590	COG1132	(ABC) transporter
JS278_RS01600	COG0737	Belongs to the 5'-nucleotidase family
JS278_RS01605	COG0366	Alpha amylase catalytic
JS278_RS01610	COG0395	ABC-type sugar transport system, permease component
JS278_RS01615	COG1175	transmembrane transport
JS278_RS01650	COG1285	pathogenesis
JS278_RS01655	COG1175	transmembrane transport
JS278_RS01675	COG1472	Belongs to the glycosyl hydrolase 3 family
JS278_RS01700	COG1609	Transcriptional regulator
JS278_RS01710	COG1175	transmembrane transport
JS278_RS01725	COG1609	Transcriptional regulator
JS278_RS01735	COG1175	transmembrane transport
JS278_RS01740	COG0395	ABC-type sugar transport system, permease component
JS278_RS01765	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
JS278_RS01765	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
JS278_RS01770	COG0366	Alpha amylase catalytic
JS278_RS01805	COG0531	amino acid
JS278_RS01815	COG1113	amino acid transport
JS278_RS01820	COG0686	Belongs to the AlaDH PNT family
JS278_RS01910	COG0535	radical SAM domain protein
JS278_RS01925	COG0022	dehydrogenase e1 component
JS278_RS01930	COG0508	dehydrogenase complex catalyzes the overall conversion of
JS278_RS01940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JS278_RS01950	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JS278_RS01965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JS278_RS01980	COG0395	ABC-type sugar transport system, permease component
JS278_RS01995	COG1609	Transcriptional regulator
JS278_RS02000	COG0561	phosphatase activity
JS278_RS02025	COG3321	synthase
JS278_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_RS02025	COG0604	alcohol dehydrogenase
JS278_RS02050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JS278_RS02085	COG0584	glycerophosphoryl diester phosphodiesterase
JS278_RS02090	COG1506	peptidase
JS278_RS02090	COG0823	Involved in the tonB-independent uptake of proteins
JS278_RS02090	COG4946	Tricorn protease homolog
JS278_RS02095	COG2130	NADP-dependent
JS278_RS02115	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JS278_RS02125	COG0590	tRNA wobble adenosine to inosine editing
JS278_RS02165	COG1174	glycine betaine transport
JS278_RS02180	COG3263	regulation of cellular component size
JS278_RS02220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JS278_RS02240	COG2188	Transcriptional regulator
JS278_RS02260	COG1942	4-Oxalocrotonate Tautomerase
JS278_RS02265	COG0673	inositol 2-dehydrogenase activity
JS278_RS02275	COG1946	Acyl-CoA thioesterase
JS278_RS02300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JS278_RS02310	COG3716	PTS system mannose fructose sorbose family IID component
JS278_RS02315	COG3715	PTS system
JS278_RS02320	COG2188	Transcriptional regulator
JS278_RS02335	COG2376	Dihydroxyacetone kinase
JS278_RS02345	COG1609	Transcriptional regulator
JS278_RS02350	COG0395	ABC-type sugar transport system, permease component
JS278_RS02355	COG1175	transmembrane transport
JS278_RS02380	COG3340	Belongs to the peptidase S51 family
JS278_RS02385	COG1414	Transcriptional regulator
JS278_RS02395	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JS278_RS02400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JS278_RS02405	COG2390	Transcriptional regulator
JS278_RS02410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JS278_RS02425	COG0235	Class ii aldolase
JS278_RS02430	COG0656	L-ascorbic acid biosynthetic process
JS278_RS02440	COG1063	alcohol dehydrogenase
JS278_RS02450	COG1609	Transcriptional regulator
JS278_RS02455	COG0445	tRNA wobble uridine modification
JS278_RS02460	COG2271	Major facilitator Superfamily
JS278_RS02465	COG1349	DNA-binding transcription factor activity
JS278_RS02480	COG1501	Belongs to the glycosyl hydrolase 31 family
JS278_RS02495	COG3684	Belongs to the aldolase LacD family
JS278_RS02500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS278_RS02520	COG1518	maintenance of DNA repeat elements
JS278_RS02520	COG1468	defense response to virus
JS278_RS02565	COG4572	Cation transport regulator
JS278_RS02580	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_RS02590	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
JS278_RS02595	COG0783	Belongs to the Dps family
JS278_RS02605	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_RS02625	COG0753	catalase activity
JS278_RS02645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JS278_RS02645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JS278_RS02660	COG2124	cytochrome p450
JS278_RS02680	COG1295	ribonuclease BN
JS278_RS02715	COG0534	Mate efflux family protein
JS278_RS02735	COG4942	peptidase
JS278_RS02740	COG3177	Filamentation induced by cAMP protein fic
JS278_RS02750	COG2826	transposase and inactivated derivatives, IS30 family
JS278_RS02760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JS278_RS02775	COG1072	(Pantothenic acid kinase))
JS278_RS02780	COG1069	ribulokinase activity
JS278_RS02790	COG0254	rRNA binding
JS278_RS02795	COG3022	response to hydroperoxide
JS278_RS02805	COG4608	Belongs to the ABC transporter superfamily
JS278_RS02815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JS278_RS02820	COG0601	transmembrane transport
JS278_RS02850	COG1846	Transcriptional regulator
JS278_RS02855	COG2040	homocysteine
JS278_RS02860	COG0833	amino acid
JS278_RS02895	COG1408	metallophosphoesterase
JS278_RS02935	COG0494	nUDIX hydrolase
JS278_RS03060	COG2026	Addiction module toxin, RelE StbE family
JS278_RS03065	COG1205	dead DEAH box helicase
JS278_RS03065	COG1111	helicase
JS278_RS03070	COG2890	protein-(glutamine-N5) methyltransferase activity
JS278_RS03080	COG1754	DNA topoisomerase type I activity
JS278_RS03080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JS278_RS03090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JS278_RS03095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JS278_RS03105	COG1774	PSP1 C-terminal conserved region
JS278_RS03130	COG4115	mRNA cleavage
JS278_RS03135	COG2161	toxin-antitoxin pair type II binding
JS278_RS03155	COG1231	oxidoreductase activity
JS278_RS03160	COG0431	NADPH-dependent FMN reductase
JS278_RS03185	COG0601	transmembrane transport
JS278_RS03190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JS278_RS03200	COG1619	proteins homologs of microcin C7 resistance protein MccF
JS278_RS03260	COG3458	cephalosporin-C deacetylase activity
JS278_RS03270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JS278_RS03280	COG0037	tRNA processing
JS278_RS03295	COG0302	gtp cyclohydrolase
JS278_RS03310	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JS278_RS03320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JS278_RS03335	COG0649	NAD binding
JS278_RS03355	COG0270	DNA (cytosine-5-)-methyltransferase activity
JS278_RS03430	COG0705	Rhomboid family
JS278_RS03430	COG0457	Tetratricopeptide repeat
JS278_RS03440	COG4143	(ABC) transporter
JS278_RS03450	COG3842	ATPase activity
JS278_RS03475	COG1194	a g-specific adenine glycosylase
JS278_RS03480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JS278_RS03485	COG0113	porphobilinogen synthase activity
JS278_RS03495	COG0181	hydroxymethylbilane synthase activity
JS278_RS03505	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JS278_RS03510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JS278_RS03515	COG3253	May function as heme-dependent peroxidase
JS278_RS03515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JS278_RS03525	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
JS278_RS03530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JS278_RS03540	COG1082	Xylose isomerase domain protein TIM barrel
JS278_RS03575	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JS278_RS03585	COG0406	alpha-ribazole phosphatase activity
JS278_RS03590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JS278_RS03595	COG0785	Cytochrome C biogenesis protein
JS278_RS03605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JS278_RS03625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JS278_RS03635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JS278_RS03640	COG0129	dihydroxy-acid dehydratase activity
JS278_RS03660	COG1120	ATPase activity
JS278_RS03665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JS278_RS03670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JS278_RS03675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JS278_RS03680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JS278_RS03685	COG0581	inorganic phosphate transmembrane transporter activity
JS278_RS03705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JS278_RS03710	COG0745	RESPONSE REGULATOR receiver
JS278_RS03730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JS278_RS03740	COG1490	D-aminoacyl-tRNA deacylase activity
JS278_RS03745	COG3485	protocatechuate 3,4-dioxygenase
JS278_RS03755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JS278_RS03775	COG1217	gtp-binding protein TYPA
JS278_RS03790	COG1937	Protein conserved in bacteria
JS278_RS03805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JS278_RS03820	COG4423	Transcription factor
JS278_RS03830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JS278_RS03835	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JS278_RS03840	COG0047	phosphoribosylformylglycinamidine synthase activity
JS278_RS03845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JS278_RS03850	COG1113	amino acid transport
JS278_RS03855	COG0252	asparaginase activity
JS278_RS03865	COG1703	isobutyryl-CoA mutase activity
JS278_RS03870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JS278_RS03910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JS278_RS03930	COG1175	transmembrane transport
JS278_RS03935	COG0395	ABC-type sugar transport system, permease component
JS278_RS04055	COG1196	nuclear chromosome segregation
JS278_RS04055	COG0741	lytic transglycosylase activity
JS278_RS04055	COG0739	heme binding
JS278_RS04170	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_RS04185	COG0477	Major facilitator Superfamily
JS278_RS04195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JS278_RS04240	COG2084	Dehydrogenase
JS278_RS04255	COG3848	Pyruvate phosphate dikinase
JS278_RS04255	COG0574	Belongs to the PEP-utilizing enzyme family
JS278_RS04290	COG1304	FMN binding
JS278_RS04305	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JS278_RS04310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JS278_RS04325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JS278_RS04350	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JS278_RS04370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JS278_RS04370	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JS278_RS04370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS278_RS04375	COG1461	Dihydroxyacetone kinase
JS278_RS04380	COG2376	Dihydroxyacetone kinase
JS278_RS04400	COG1132	(ABC) transporter
JS278_RS04410	COG2226	methyltransferase
JS278_RS04440	COG0644	oxidoreductase
JS278_RS04450	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JS278_RS04455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JS278_RS04460	COG0649	NAD binding
JS278_RS04470	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JS278_RS04475	COG1034	ATP synthesis coupled electron transport
JS278_RS04480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JS278_RS04485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JS278_RS04495	COG0713	ATP synthesis coupled electron transport
JS278_RS04510	COG1007	ATP synthesis coupled electron transport
JS278_RS04515	COG0142	geranyltranstransferase activity
JS278_RS04525	COG3590	peptidase
JS278_RS04530	COG1013	pyruvate-flavodoxin oxidoreductase activity
JS278_RS04535	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JS278_RS04535	COG0674	pyruvate-flavodoxin oxidoreductase activity
JS278_RS04540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JS278_RS04550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JS278_RS04590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JS278_RS04595	COG2030	dehydratase
JS278_RS04605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JS278_RS04610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JS278_RS04625	COG0250	Participates in transcription elongation, termination and antitermination
JS278_RS04630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JS278_RS04635	COG0081	regulation of translation
JS278_RS04640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JS278_RS04645	COG0222	ribosome binding
JS278_RS04650	COG0085	RNA polymerase activity
JS278_RS04655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JS278_RS04665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JS278_RS04670	COG0049	tRNA binding
JS278_RS04675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JS278_RS04680	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JS278_RS04695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JS278_RS04700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JS278_RS04705	COG0051	transcription antitermination factor activity, RNA binding
JS278_RS04710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JS278_RS04715	COG0088	Forms part of the polypeptide exit tunnel
JS278_RS04720	COG0089	rRNA binding
JS278_RS04725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JS278_RS04730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JS278_RS04735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JS278_RS04740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JS278_RS04745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JS278_RS04750	COG0255	Belongs to the universal ribosomal protein uL29 family
JS278_RS04755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JS278_RS04765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JS278_RS04770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JS278_RS04775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JS278_RS04780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JS278_RS04785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JS278_RS04790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JS278_RS04795	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JS278_RS04800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JS278_RS04805	COG1841	ribosomal large subunit assembly
JS278_RS04810	COG0200	Binds to the 23S rRNA
JS278_RS04845	COG0563	adenylate kinase activity
JS278_RS04865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JS278_RS04870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JS278_RS04880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JS278_RS04885	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JS278_RS04890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JS278_RS04895	COG0202	RNA polymerase activity
JS278_RS04900	COG0203	ribosomal protein L17
JS278_RS04905	COG2826	transposase and inactivated derivatives, IS30 family
JS278_RS04915	COG0438	transferase activity, transferring glycosyl groups
JS278_RS04925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JS278_RS04925	COG0519	Catalyzes the synthesis of GMP from XMP
JS278_RS04940	COG3845	ABC transporter
JS278_RS04960	COG0101	tRNA pseudouridine synthase activity
JS278_RS04965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JS278_RS04975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JS278_RS04980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JS278_RS04990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JS278_RS05000	COG1072	(Pantothenic acid kinase))
JS278_RS05005	COG2226	methyltransferase
JS278_RS05010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JS278_RS05015	COG0736	holo-[acyl-carrier-protein] synthase activity
JS278_RS05030	COG0513	Belongs to the DEAD box helicase family
JS278_RS05035	COG0802	atpase or kinase
JS278_RS05040	COG1214	PFAM Peptidase M22, glycoprotease
JS278_RS05040	COG0456	acetyltransferase
JS278_RS05050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JS278_RS05070	COG1355	regulation of microtubule-based process
JS278_RS05090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JS278_RS05095	COG0459	protein refolding
JS278_RS05120	COG0287	Prephenate dehydrogenase
JS278_RS05120	COG1605	Chorismate mutase
JS278_RS05125	COG1045	serine acetyltransferase
JS278_RS05130	COG0519	Catalyzes the synthesis of GMP from XMP
JS278_RS05130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JS278_RS05155	COG2197	response regulator
JS278_RS05160	COG2261	transglycosylase associated protein
JS278_RS05165	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JS278_RS05170	COG2011	ABC-type metal ion transport system permease component
JS278_RS05175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JS278_RS05180	COG1464	Belongs to the NlpA lipoprotein family
JS278_RS05195	COG0045	succinate-CoA ligase (ADP-forming) activity
JS278_RS05225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JS278_RS05225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JS278_RS05230	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JS278_RS05240	COG0138	bifunctional purine biosynthesis protein purh
JS278_RS05250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JS278_RS05265	COG0039	L-malate dehydrogenase activity
JS278_RS05285	COG1253	flavin adenine dinucleotide binding
JS278_RS05300	COG1744	ABC transporter substrate-binding protein PnrA-like
JS278_RS05305	COG3845	ABC transporter
JS278_RS05310	COG4603	Belongs to the binding-protein-dependent transport system permease family
JS278_RS05315	COG1079	Belongs to the binding-protein-dependent transport system permease family
JS278_RS05325	COG0328	RNA-DNA hybrid ribonuclease activity
JS278_RS05340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JS278_RS05355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JS278_RS05375	COG4770	biotin carboxylase activity
JS278_RS05385	COG0351	phosphomethylpyrimidine kinase
JS278_RS05395	COG4221	oxidoreductase activity
JS278_RS05410	COG0424	maF-like protein
JS278_RS05420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JS278_RS05430	COG3340	Belongs to the peptidase S51 family
JS278_RS05450	COG1316	TRANSCRIPTIONal
JS278_RS05465	COG0662	Cupin 2, conserved barrel domain protein
JS278_RS05465	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
JS278_RS05510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JS278_RS05515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JS278_RS05545	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JS278_RS05560	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JS278_RS05560	COG1918	ferrous iron import across plasma membrane
JS278_RS05570	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JS278_RS05575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JS278_RS05580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JS278_RS05585	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JS278_RS05595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JS278_RS05600	COG2197	response regulator
JS278_RS05605	COG4585	Histidine kinase
JS278_RS05695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JS278_RS05710	COG0587	DNA-directed DNA polymerase activity
JS278_RS05715	COG0531	amino acid
JS278_RS05750	COG1113	amino acid transport
JS278_RS05800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JS278_RS05815	COG2818	Glycosylase
JS278_RS05830	COG0438	transferase activity, transferring glycosyl groups
JS278_RS05845	COG1733	regulation of RNA biosynthetic process
JS278_RS05910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JS278_RS05935	COG0277	FAD linked oxidase domain protein
JS278_RS05935	COG0247	lactate metabolic process
JS278_RS05950	COG1022	Amp-dependent synthetase and ligase
JS278_RS05980	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JS278_RS05995	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JS278_RS06000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JS278_RS06035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JS278_RS06035	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JS278_RS06070	COG4974	Belongs to the 'phage' integrase family
JS278_RS06090	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_RS06100	COG0544	peptidyl-prolyl cis-trans isomerase activity
JS278_RS06105	COG0628	permease
JS278_RS06110	COG0740	serine-type endopeptidase activity
JS278_RS06115	COG0740	serine-type endopeptidase activity
JS278_RS06120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JS278_RS06130	COG4946	Tricorn protease homolog
JS278_RS06130	COG0793	Belongs to the peptidase S41A family
JS278_RS06140	COG0525	valine-tRNA ligase activity
JS278_RS06150	COG0363	glucosamine-6-phosphate deaminase activity
JS278_RS06165	COG0109	protoheme IX farnesyltransferase activity
JS278_RS06180	COG1131	(ABC) transporter
JS278_RS06185	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
JS278_RS06190	COG1609	Transcriptional regulator
JS278_RS06195	COG3833	ABC-type maltose transport systems, permease component
JS278_RS06200	COG1175	transmembrane transport
JS278_RS06220	COG0719	Fe-S assembly protein
JS278_RS06230	COG0396	ATPase activity
JS278_RS06235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JS278_RS06285	COG0488	(ABC) transporter
JS278_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_RS06335	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JS278_RS06340	COG1119	ATPase activity
JS278_RS06410	COG0242	peptide deformylase activity
JS278_RS06430	COG4974	Belongs to the 'phage' integrase family
JS278_RS06445	COG3552	Protein containing von Willebrand factor type A (VWA) domain
JS278_RS06450	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JS278_RS06455	COG0714	Associated with various cellular activities
JS278_RS06460	COG3831	ATPase activity
JS278_RS06465	COG0052	Belongs to the universal ribosomal protein uS2 family
JS278_RS06470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JS278_RS06475	COG0528	UMP kinase activity
JS278_RS06480	COG0233	cytoplasmic translational termination
JS278_RS06485	COG0575	Belongs to the CDS family
JS278_RS06490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JS278_RS06495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JS278_RS06505	COG0750	zinc metalloprotease
JS278_RS06515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JS278_RS06545	COG1305	Transglutaminase-like
JS278_RS06555	COG0442	prolyl-tRNA aminoacylation
JS278_RS06575	COG0779	Required for maturation of 30S ribosomal subunits
JS278_RS06590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JS278_RS06595	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JS278_RS06600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JS278_RS06605	COG0371	Dehydrogenase
JS278_RS06620	COG3732	PTS system glucitol sorbitol-specific
JS278_RS06640	COG1028	Short-chain dehydrogenase reductase Sdr
JS278_RS06645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JS278_RS06650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JS278_RS06660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JS278_RS06665	COG1185	polyribonucleotide nucleotidyltransferase activity
JS278_RS06670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JS278_RS06680	COG0028	Belongs to the TPP enzyme family
JS278_RS06690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JS278_RS06695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JS278_RS06710	COG0742	ribosomal rna small subunit methyltransferase
JS278_RS06715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JS278_RS06725	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JS278_RS06730	COG0571	ribonuclease III activity
JS278_RS06735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JS278_RS06770	COG0228	four-way junction DNA binding
JS278_RS06775	COG1837	Belongs to the UPF0109 family
JS278_RS06780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JS278_RS06785	COG0336	Belongs to the RNA methyltransferase TrmD family
JS278_RS06795	COG1053	succinate dehydrogenase
JS278_RS06800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JS278_RS06805	COG0335	large ribosomal subunit rRNA binding
JS278_RS06810	COG0681	Belongs to the peptidase S26 family
JS278_RS06815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JS278_RS06825	COG0792	nuclease activity
JS278_RS06855	COG1175	transmembrane transport
JS278_RS06860	COG0395	ABC-type sugar transport system, permease component
JS278_RS06865	COG1609	Transcriptional regulator
JS278_RS06880	COG2160	L-arabinose isomerase activity
JS278_RS06885	COG1609	Transcriptional regulator
JS278_RS06890	COG0673	inositol 2-dehydrogenase activity
JS278_RS06900	COG2814	Major facilitator Superfamily
JS278_RS06915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JS278_RS06925	COG0667	Aldo Keto reductase
JS278_RS06935	COG3201	nicotinamide mononucleotide transporter
JS278_RS06940	COG0140	phosphoribosyl-ATP diphosphatase activity
JS278_RS06945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JS278_RS06980	COG0647	UMP catabolic process
JS278_RS06985	COG1268	BioY protein
JS278_RS06990	COG1122	ATPase activity
JS278_RS07005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JS278_RS07010	COG0497	DNA recombination
JS278_RS07015	COG0504	CTP synthase activity
JS278_RS07050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JS278_RS07070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JS278_RS07075	COG0805	protein transport
JS278_RS07085	COG4581	dead DEAH box helicase
JS278_RS07090	COG0107	imidazoleglycerol-phosphate synthase activity
JS278_RS07095	COG0537	adenosine 5'-monophosphoramidase activity
JS278_RS07105	COG0440	acetolactate synthase activity
JS278_RS07110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JS278_RS07130	COG0473	3-isopropylmalate dehydrogenase activity
JS278_RS07135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JS278_RS07140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JS278_RS07150	COG0179	Fumarylacetoacetate (FAA) hydrolase
JS278_RS07170	COG1414	Transcriptional regulator
JS278_RS07175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JS278_RS07180	COG0066	3-isopropylmalate dehydratase activity
JS278_RS07190	COG1181	Belongs to the D-alanine--D-alanine ligase family
JS278_RS07205	COG1674	ftsk spoiiie
JS278_RS07215	COG3152	Membrane
JS278_RS07225	COG0667	Aldo Keto reductase
JS278_RS07235	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
JS278_RS07240	COG2884	Cell division ATP-binding protein ftsE
JS278_RS07245	COG2177	Part of the ABC transporter FtsEX involved in
JS278_RS07250	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JS278_RS07255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JS278_RS07265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JS278_RS07270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JS278_RS07275	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JS278_RS07280	COG0165	Argininosuccinate lyase
JS278_RS07295	COG1678	Uncharacterized ACR, COG1678
JS278_RS07300	COG0745	RESPONSE REGULATOR receiver
JS278_RS07305	COG5002	protein histidine kinase activity
JS278_RS07310	COG5401	PFAM Sporulation and spore germination
JS278_RS07320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JS278_RS07330	COG0653	protein targeting
JS278_RS07350	COG0613	PHP domain protein
JS278_RS07360	COG0180	Tryptophanyl-tRNA synthetase
JS278_RS07385	COG1278	Cold shock
JS278_RS07405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JS278_RS07410	COG1074	ATP-dependent DNA helicase activity
JS278_RS07415	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JS278_RS07440	COG3480	Lon protease (S16) C-terminal proteolytic domain
JS278_RS07450	COG1615	UPF0182 protein
JS278_RS07460	COG1472	Belongs to the glycosyl hydrolase 3 family
JS278_RS07480	COG0747	negative chemotaxis
JS278_RS07490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JS278_RS07500	COG4172	Belongs to the ABC transporter superfamily
JS278_RS07505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JS278_RS07510	COG0483	inositol monophosphate 1-phosphatase activity
JS278_RS07515	COG1162	GTPase activity
JS278_RS07520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JS278_RS07530	COG1595	DNA-templated transcription, initiation
JS278_RS07555	COG0567	Dehydrogenase, E1 component
JS278_RS07555	COG0508	dehydrogenase complex catalyzes the overall conversion of
JS278_RS07565	COG1611	Belongs to the LOG family
JS278_RS07575	COG0019	diaminopimelate decarboxylase activity
JS278_RS07580	COG0460	homoserine dehydrogenase
JS278_RS07585	COG0083	homoserine kinase activity
JS278_RS07595	COG0254	rRNA binding
JS278_RS07600	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JS278_RS07605	COG2890	protein-(glutamine-N5) methyltransferase activity
JS278_RS07610	COG0009	L-threonylcarbamoyladenylate synthase
JS278_RS07615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JS278_RS07625	COG2244	polysaccharide biosynthetic process
JS278_RS07685	COG0318	PFAM AMP-dependent synthetase and ligase
JS278_RS07695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JS278_RS07700	COG0367	asparagine synthase
JS278_RS07710	COG1045	serine acetyltransferase
JS278_RS07725	COG0356	it plays a direct role in the translocation of protons across the membrane
JS278_RS07730	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JS278_RS07735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JS278_RS07740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JS278_RS07745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JS278_RS07750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JS278_RS07755	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JS278_RS07760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JS278_RS07780	COG0596	Alpha beta hydrolase
JS278_RS07810	COG0033	Phosphoglucomutase
JS278_RS07835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JS278_RS07840	COG3281	Trehalose synthase
JS278_RS07845	COG0366	Alpha amylase catalytic
JS278_RS07865	COG1104	cysteine desulfurase activity
JS278_RS07870	COG0482	sulfurtransferase activity
JS278_RS07895	COG0842	Transport permease protein
JS278_RS07895	COG1129	ABC transporter
JS278_RS07910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JS278_RS07925	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JS278_RS07930	COG0154	amidase activity
JS278_RS07935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JS278_RS07940	COG2233	PERMEase
JS278_RS07955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JS278_RS07960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JS278_RS07975	COG0134	indole-3-glycerol-phosphate synthase activity
JS278_RS07980	COG0133	tryptophan synthase activity
JS278_RS07985	COG0159	tryptophan synthase activity
JS278_RS07990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JS278_RS07995	COG0070	glutamate synthase
JS278_RS07995	COG0067	glutamate synthase
JS278_RS07995	COG0069	glutamate synthase activity
JS278_RS08025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JS278_RS08030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JS278_RS08035	COG0131	Imidazoleglycerol-phosphate dehydratase
JS278_RS08040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JS278_RS08045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JS278_RS08050	COG0217	transcriptional regulatory protein
JS278_RS08055	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
JS278_RS08060	COG0632	four-way junction helicase activity
JS278_RS08065	COG2255	four-way junction helicase activity
JS278_RS08075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JS278_RS08080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JS278_RS08085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JS278_RS08095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JS278_RS08100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JS278_RS08105	COG1196	nuclear chromosome segregation
JS278_RS08115	COG0124	histidyl-tRNA synthetase
JS278_RS08125	COG1309	transcriptional regulator
JS278_RS08135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JS278_RS08140	COG2161	toxin-antitoxin pair type II binding
JS278_RS08180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JS278_RS08185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JS278_RS08190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JS278_RS08195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JS278_RS08200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JS278_RS08210	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JS278_RS08220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JS278_RS08225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JS278_RS08235	COG0194	GDP metabolic process
JS278_RS08240	COG1758	RNA polymerase activity
JS278_RS08250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JS278_RS08255	COG1201	RNA secondary structure unwinding
JS278_RS08260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JS278_RS08275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JS278_RS08280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JS278_RS08290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JS278_RS08300	COG0646	methionine synthase
JS278_RS08300	COG1410	methionine synthase
JS278_RS08315	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JS278_RS08320	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
JS278_RS08330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JS278_RS08335	COG1160	GTP binding
JS278_RS08345	COG1764	response to oxidative stress
JS278_RS08360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JS278_RS08410	COG1484	DNA-dependent DNA replication
JS278_RS08460	COG2326	polyphosphate kinase activity
JS278_RS08470	COG1414	Transcriptional regulator
JS278_RS08480	COG1725	Transcriptional regulator
JS278_RS08490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JS278_RS08520	COG3226	Transcriptional regulator
JS278_RS08535	COG0740	serine-type endopeptidase activity
JS278_RS08540	COG0740	serine-type endopeptidase activity
JS278_RS08545	COG1793	dna ligase
JS278_RS08545	COG3285	dna ligase
JS278_RS08560	COG3550	peptidyl-serine autophosphorylation
JS278_RS08590	COG2807	transmembrane transport
JS278_RS08605	COG0427	acetyl-CoA hydrolase
JS278_RS08610	COG2873	o-acetylhomoserine
JS278_RS08615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JS278_RS08620	COG2813	Specifically methylates the guanine in position
JS278_RS08620	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JS278_RS08625	COG1522	sequence-specific DNA binding
JS278_RS08630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JS278_RS08635	COG1216	Glycosyl transferase, family 2
JS278_RS08645	COG0584	glycerophosphoryl diester phosphodiesterase
JS278_RS08655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JS278_RS08665	COG1966	Carbon starvation protein
JS278_RS08680	COG0531	amino acid
JS278_RS08700	COG0443	Heat shock 70 kDa protein
JS278_RS08710	COG1739	Uncharacterized protein family UPF0029
JS278_RS08720	COG1597	lipid kinase activity
JS278_RS08730	COG0009	L-threonylcarbamoyladenylate synthase
JS278_RS08740	COG0205	6-phosphofructokinase activity
JS278_RS08745	COG1295	ribonuclease BN
JS278_RS08765	COG1716	ATPase activity
JS278_RS08795	COG0438	transferase activity, transferring glycosyl groups
JS278_RS08800	COG1560	Kdo2-lipid A biosynthetic process
JS278_RS08805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JS278_RS08815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JS278_RS08820	COG1064	alcohol dehydrogenase
JS278_RS08865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JS278_RS08870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JS278_RS08875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JS278_RS08880	COG0531	amino acid
JS278_RS08885	COG0569	domain protein
JS278_RS08905	COG0756	dUTP diphosphatase activity
JS278_RS08940	COG1297	OPT oligopeptide transporter protein
JS278_RS08950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JS278_RS08970	COG0187	DNA topoisomerase II activity
JS278_RS08985	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JS278_RS08995	COG1643	Atp-dependent helicase
JS278_RS09015	COG0717	Belongs to the dCTP deaminase family
JS278_RS09020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JS278_RS09025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JS278_RS09040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JS278_RS09045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JS278_RS09050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JS278_RS09060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JS278_RS09065	COG2017	converts alpha-aldose to the beta-anomer
JS278_RS09070	COG1418	mRNA catabolic process
JS278_RS09090	COG1349	DNA-binding transcription factor activity
JS278_RS09095	COG1396	sequence-specific DNA binding
JS278_RS09100	COG1546	Belongs to the CinA family
JS278_RS09100	COG1058	Belongs to the CinA family
JS278_RS09110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JS278_RS09120	COG4115	mRNA cleavage
JS278_RS09135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JS278_RS09140	COG0284	orotidine-5'-phosphate decarboxylase activity
JS278_RS09145	COG0167	dihydroorotate dehydrogenase activity
JS278_RS09150	COG0543	2 iron, 2 sulfur cluster binding
JS278_RS09155	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JS278_RS09160	COG0505	Belongs to the CarA family
JS278_RS09185	COG0667	Aldo Keto reductase
JS278_RS09195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JS278_RS09210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JS278_RS09220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JS278_RS09225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JS278_RS09230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JS278_RS09240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JS278_RS09245	COG2304	oxidoreductase activity
JS278_RS09250	COG2304	oxidoreductase activity
JS278_RS09260	COG0714	Associated with various cellular activities
JS278_RS09320	COG0515	serine threonine protein kinase
JS278_RS09325	COG0583	DNA-binding transcription factor activity
JS278_RS09335	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JS278_RS09345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JS278_RS09365	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
JS278_RS09370	COG0488	(ABC) transporter
JS278_RS09395	COG0358	DNA primase activity
JS278_RS09400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JS278_RS09430	COG1053	succinate dehydrogenase
JS278_RS09440	COG0076	glutamate decarboxylase activity
JS278_RS09455	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JS278_RS09465	COG0423	glycine-tRNA ligase activity
JS278_RS09480	COG1381	Involved in DNA repair and RecF pathway recombination
JS278_RS09485	COG1404	Belongs to the peptidase S8 family
JS278_RS09495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JS278_RS09505	COG0765	amino acid transport
JS278_RS09510	COG0765	amino acid transport
JS278_RS09515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JS278_RS09520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JS278_RS09530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JS278_RS09540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JS278_RS09600	COG4152	abc transporter atp-binding protein
JS278_RS09605	COG2197	response regulator
JS278_RS09610	COG4585	Histidine kinase
JS278_RS09615	COG0343	queuine tRNA-ribosyltransferase activity
JS278_RS09620	COG5006	permease, DMT superfamily
JS278_RS09645	COG0246	Mannitol dehydrogenase
JS278_RS09655	COG0484	heat shock protein binding
JS278_RS09660	COG1420	regulation of RNA biosynthetic process
JS278_RS09665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JS278_RS09670	COG0483	inositol monophosphate 1-phosphatase activity
JS278_RS09690	COG1175	transmembrane transport
JS278_RS09705	COG0477	Major facilitator Superfamily
JS278_RS09710	COG1309	transcriptional regulator
JS278_RS09715	COG1131	(ABC) transporter
JS278_RS09725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JS278_RS09730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JS278_RS09740	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JS278_RS09750	COG1169	isochorismate synthase
JS278_RS09755	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JS278_RS09760	COG4948	Mandelate Racemase Muconate Lactonizing
JS278_RS09785	COG0481	GTPase activity
JS278_RS09790	COG0268	Binds directly to 16S ribosomal RNA
JS278_RS09800	COG1061	Type III restriction enzyme res subunit
JS278_RS09805	COG0658	competence protein
JS278_RS09805	COG2333	competence protein COMEC
JS278_RS09815	COG0495	leucyl-tRNA aminoacylation
JS278_RS09840	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JS278_RS09900	COG0488	(ABC) transporter
JS278_RS09905	COG3226	Transcriptional regulator
JS278_RS09930	COG1131	(ABC) transporter
JS278_RS09940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JS278_RS09965	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JS278_RS10005	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JS278_RS10010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JS278_RS10015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JS278_RS10020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JS278_RS10035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JS278_RS10040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JS278_RS10045	COG1530	ribonuclease E activity
JS278_RS10055	COG1472	Belongs to the glycosyl hydrolase 3 family
JS278_RS10065	COG0105	UTP biosynthetic process
JS278_RS10075	COG0285	dihydrofolate synthase activity
JS278_RS10085	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JS278_RS10090	COG0149	triose-phosphate isomerase activity
JS278_RS10095	COG0126	phosphoglycerate kinase activity
JS278_RS10100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JS278_RS10105	COG1481	regulation of sporulation
JS278_RS10115	COG1660	Displays ATPase and GTPase activities
JS278_RS10120	COG0322	excinuclease ABC activity
JS278_RS10135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JS278_RS10150	COG0556	nucleotide-excision repair
JS278_RS10155	COG0237	dephospho-CoA kinase activity
JS278_RS10160	COG0539	negative regulation of cytoplasmic translation
JS278_RS10185	COG2050	protein possibly involved in aromatic compounds catabolism
JS278_RS10200	COG0469	pyruvate kinase activity
JS278_RS10210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JS278_RS10230	COG1799	cell septum assembly
JS278_RS10235	COG1496	oxidoreductase activity
JS278_RS10240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JS278_RS10250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JS278_RS10255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JS278_RS10260	COG0772	Belongs to the SEDS family
JS278_RS10265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JS278_RS10270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JS278_RS10275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JS278_RS10285	COG0768	penicillin binding
JS278_RS10295	COG0275	rRNA processing
JS278_RS10300	COG2001	Belongs to the MraZ family
JS278_RS10305	COG0714	Associated with various cellular activities
JS278_RS10325	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JS278_RS10330	COG0509	glycine decarboxylation via glycine cleavage system
JS278_RS10335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JS278_RS10335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JS278_RS10345	COG3265	gluconokinase activity
JS278_RS10355	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JS278_RS10370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JS278_RS10370	COG1116	anion transmembrane transporter activity
JS278_RS10385	COG0210	DNA helicase
JS278_RS10395	COG0142	geranyltranstransferase activity
JS278_RS10400	COG0352	thiamine-phosphate diphosphorylase activity
JS278_RS10410	COG0515	serine threonine protein kinase
JS278_RS10410	COG2815	serine threonine protein kinase
JS278_RS10425	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
JS278_RS10430	COG2197	response regulator
JS278_RS10450	COG1940	carbohydrate kinase activity
JS278_RS10455	COG1388	LysM domain
JS278_RS10455	COG0791	NLP P60 protein
JS278_RS10455	COG3103	Sh3 type 3 domain protein
JS278_RS10495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JS278_RS10505	COG1845	cytochrome c oxidase, subunit III
JS278_RS10510	COG2010	Cytochrome c
JS278_RS10515	COG0723	plastoquinol--plastocyanin reductase activity
JS278_RS10520	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
JS278_RS10540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JS278_RS10545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JS278_RS10585	COG0508	dehydrogenase complex catalyzes the overall conversion of
JS278_RS10590	COG0321	lipoyl(octanoyl) transferase activity
JS278_RS10610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JS278_RS10620	COG0488	(ABC) transporter
JS278_RS10630	COG0586	Pfam SNARE associated Golgi protein
JS278_RS10635	COG0438	transferase activity, transferring glycosyl groups
JS278_RS10650	COG0174	glutamine synthetase
JS278_RS10665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JS278_RS10675	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JS278_RS10685	COG0174	glutamine synthetase
JS278_RS10725	COG2197	response regulator
JS278_RS10735	COG0598	Magnesium transport protein CorA
JS278_RS10755	COG0531	amino acid
JS278_RS10775	COG0006	proline dipeptidase activity
JS278_RS10810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JS278_RS10815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JS278_RS10830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JS278_RS10835	COG0297	glycogen (starch) synthase activity
JS278_RS10850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JS278_RS10855	COG2171	N-acyltransferase activity
JS278_RS10885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JS278_RS10890	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JS278_RS10895	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JS278_RS10940	COG0647	UMP catabolic process
JS278_RS10950	COG0698	ribose 5-phosphate isomerase
JS278_RS10955	COG1349	DNA-binding transcription factor activity
JS278_RS10960	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JS278_RS10965	COG2376	Dihydroxyacetone kinase
JS278_RS10970	COG1063	alcohol dehydrogenase
JS278_RS10975	COG1012	belongs to the aldehyde dehydrogenase family
JS278_RS10995	COG1121	(ABC) transporter
JS278_RS11000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JS278_RS11030	COG0765	amino acid transport
JS278_RS11050	COG2501	S4 domain
JS278_RS11080	COG0366	Alpha amylase catalytic
JS278_RS11085	COG0833	amino acid
JS278_RS11090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JS278_RS11095	COG0667	Aldo Keto reductase
JS278_RS11100	COG2133	pyrroloquinoline quinone binding
JS278_RS11105	COG2716	regulation of RNA biosynthetic process
JS278_RS11140	COG0477	Major facilitator Superfamily
JS278_RS11145	COG0477	Major facilitator Superfamily
JS278_RS11150	COG0604	alcohol dehydrogenase
JS278_RS11150	COG3321	synthase
JS278_RS11155	COG1082	Xylose isomerase domain protein TIM barrel
JS278_RS11160	COG0673	inositol 2-dehydrogenase activity
JS278_RS11185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JS278_RS11185	COG2169	Transcriptional regulator
JS278_RS11205	COG0406	alpha-ribazole phosphatase activity
JS278_RS11210	COG1132	(ABC) transporter
JS278_RS11225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JS278_RS11340	COG2337	Toxic component of a toxin-antitoxin (TA) module
JS278_RS11345	COG0012	GTP binding
JS278_RS11360	COG1136	(ABC) transporter
JS278_RS11360	COG0577	efflux transmembrane transporter activity
JS278_RS11365	COG1362	aminopeptidase activity
JS278_RS11370	COG1322	Protein conserved in bacteria
JS278_RS11375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JS278_RS11380	COG1570	exodeoxyribonuclease VII activity
JS278_RS11385	COG1722	exodeoxyribonuclease VII activity
JS278_RS11395	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
JS278_RS11405	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JS278_RS11410	COG1331	Highly conserved protein containing a thioredoxin domain
JS278_RS11435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JS278_RS11450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JS278_RS11455	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JS278_RS11490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JS278_RS11505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JS278_RS11510	COG0072	phenylalanine-tRNA ligase activity
JS278_RS11510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JS278_RS11515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JS278_RS11525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JS278_RS11530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JS278_RS11535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JS278_RS11540	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JS278_RS11575	COG0531	amino acid
JS278_RS11580	COG1834	amidinotransferase
JS278_RS11600	COG2837	iron assimilation
JS278_RS11610	COG2197	response regulator
JS278_RS11645	COG0148	phosphopyruvate hydratase activity
JS278_RS11670	COG1484	DNA-dependent DNA replication
JS278_RS11675	COG4584	PFAM Integrase catalytic
JS278_RS11680	COG0193	aminoacyl-tRNA hydrolase activity
JS278_RS11685	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JS278_RS11690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JS278_RS11695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JS278_RS11710	COG1846	Transcriptional regulator
JS278_RS11715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JS278_RS11720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JS278_RS11725	COG0084	hydrolase, TatD family'
JS278_RS11740	COG2233	PERMEase
JS278_RS11750	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JS278_RS11755	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JS278_RS11780	COG0657	acetylesterase activity
JS278_RS11790	COG2201	protein-glutamate methylesterase activity
JS278_RS11805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JS278_RS11815	COG0693	protein deglycase activity
JS278_RS11825	COG0789	Transcriptional regulator
JS278_RS11855	COG1053	succinate dehydrogenase
JS278_RS11875	COG0673	inositol 2-dehydrogenase activity
JS278_RS11895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JS278_RS11915	COG0436	Aminotransferase
JS278_RS11945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JS278_RS11955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JS278_RS11970	COG1970	mechanosensitive ion channel activity
JS278_RS11990	COG0673	inositol 2-dehydrogenase activity
JS278_RS11995	COG2814	Major facilitator Superfamily
JS278_RS12000	COG0673	inositol 2-dehydrogenase activity
JS278_RS12005	COG1609	Transcriptional regulator
JS278_RS12010	COG2814	Major facilitator Superfamily
JS278_RS12025	COG3962	Belongs to the TPP enzyme family
JS278_RS12030	COG3718	enzyme involved in inositol metabolism
JS278_RS12040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS278_RS12045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JS278_RS12050	COG3118	belongs to the thioredoxin family
JS278_RS12060	COG1321	iron dependent repressor
JS278_RS12070	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JS278_RS12085	COG2252	PERMEase
JS278_RS12105	COG1278	Cold shock
JS278_RS12110	COG0363	glucosamine-6-phosphate deaminase activity
JS278_RS12180	COG1482	cell wall glycoprotein biosynthetic process
JS278_RS12185	COG1854	S-ribosylhomocysteine lyase activity
JS278_RS12200	COG4115	mRNA cleavage
JS278_RS12205	COG2161	toxin-antitoxin pair type II binding
JS278_RS12235	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
JS278_RS12240	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JS278_RS12250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JS278_RS12250	COG1648	precorrin-2 dehydrogenase activity
JS278_RS12255	COG1797	cobyrinic acid a,c-diamide synthase activity
JS278_RS12260	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
JS278_RS12280	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
JS278_RS12285	COG0310	cobalt ion transport
JS278_RS12300	COG1648	precorrin-2 dehydrogenase activity
JS278_RS12300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JS278_RS12320	COG1492	cobalamin metabolic process
JS278_RS12335	COG2197	response regulator
JS278_RS12340	COG4585	Histidine kinase
JS278_RS12345	COG1131	(ABC) transporter
JS278_RS12360	COG0406	alpha-ribazole phosphatase activity
JS278_RS12365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JS278_RS12370	COG2197	response regulator
JS278_RS12375	COG4585	Histidine kinase
JS278_RS12385	COG1131	(ABC) transporter
JS278_RS12390	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
JS278_RS12400	COG0156	8-amino-7-oxononanoate synthase activity
JS278_RS12405	COG1063	alcohol dehydrogenase
JS278_RS12410	COG0395	ABC-type sugar transport system, permease component
JS278_RS12415	COG1175	transmembrane transport
JS278_RS12425	COG1940	carbohydrate kinase activity
JS278_RS12430	COG1760	l-serine dehydratase
JS278_RS12450	COG3842	ATPase activity
JS278_RS12470	COG0626	cystathionine gamma-synthase activity
JS278_RS12485	COG0215	cysteine-tRNA ligase activity
JS278_RS12490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JS278_RS12500	COG2814	Major facilitator Superfamily
JS278_RS12505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JS278_RS12535	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JS278_RS12540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JS278_RS12565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JS278_RS12570	COG1063	alcohol dehydrogenase
JS278_RS12590	COG3732	PTS system glucitol sorbitol-specific
JS278_RS12605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JS278_RS12620	COG1329	Transcriptional regulator
JS278_RS12635	COG5002	protein histidine kinase activity
JS278_RS12640	COG0704	Plays a role in the regulation of phosphate uptake
JS278_RS12645	COG0588	phosphoglycerate mutase activity
JS278_RS12650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS278_RS12655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JS278_RS12685	COG0191	fructose-bisphosphate aldolase activity
JS278_RS12700	COG0586	Pfam SNARE associated Golgi protein
JS278_RS12710	COG3291	Pkd domain containing protein
JS278_RS12715	COG0489	protein tyrosine kinase activity
JS278_RS12720	COG2244	polysaccharide biosynthetic process
JS278_RS12745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JS278_RS12765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JS278_RS12765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JS278_RS12770	COG1704	LemA family
JS278_RS12790	COG0436	Aminotransferase
JS278_RS12805	COG4176	ABC-type proline glycine betaine transport system permease component
JS278_RS12810	COG4175	Glycine betaine
JS278_RS12810	COG0517	IMP dehydrogenase activity
JS278_RS12815	COG3012	SEC-C Motif Domain Protein
JS278_RS12840	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JS278_RS12850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JS278_RS12875	COG1609	Transcriptional regulator
JS278_RS12885	COG1175	transmembrane transport
JS278_RS12890	COG0395	ABC-type sugar transport system, permease component
JS278_RS12900	COG3250	beta-galactosidase activity
JS278_RS12905	COG0702	epimerase
JS278_RS12910	COG1309	transcriptional regulator
JS278_RS12920	COG1511	domain protein
JS278_RS12940	COG1486	melibiose metabolic process
JS278_RS12950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JS278_RS12960	COG1175	transmembrane transport
JS278_RS12965	COG0395	ABC-type sugar transport system, permease component
JS278_RS12970	COG0542	response to heat
JS278_RS12980	COG3588	fructose-bisphosphate aldolase
JS278_RS13005	COG4585	Histidine kinase
JS278_RS13010	COG2197	response regulator
JS278_RS13035	COG1113	amino acid transport
JS278_RS13040	COG2985	domain, Protein
JS278_RS13040	COG0569	domain protein
JS278_RS13045	COG3527	Alpha-acetolactate decarboxylase
JS278_RS13050	COG1063	alcohol dehydrogenase
JS278_RS13055	COG0789	Transcriptional regulator
JS278_RS13060	COG0484	heat shock protein binding
JS278_RS13065	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JS278_RS13075	COG0517	IMP dehydrogenase activity
JS278_RS13075	COG1125	glycine betaine transport
JS278_RS13090	COG1764	response to oxidative stress
JS278_RS13100	COG0477	Major facilitator Superfamily
JS278_RS13115	COG0300	oxidoreductase activity
JS278_RS13130	COG0745	RESPONSE REGULATOR receiver
JS278_RS13135	COG2205	protein histidine kinase activity
JS278_RS13140	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JS278_RS13155	COG0574	Belongs to the PEP-utilizing enzyme family
JS278_RS13155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JS278_RS13165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JS278_RS13170	COG2813	Specifically methylates the guanine in position
JS278_RS13175	COG3830	Belongs to the UPF0237 family
JS278_RS13175	COG0560	Phosphoserine phosphatase
JS278_RS13200	COG1131	(ABC) transporter
JS278_RS13215	COG4608	Belongs to the ABC transporter superfamily
JS278_RS13220	COG0154	amidase activity
JS278_RS13230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JS278_RS13235	COG1027	Aspartate ammonia-lyase
JS278_RS13240	COG1228	amidohydrolase
JS278_RS13280	COG0667	Aldo Keto reductase
JS278_RS13310	COG1940	carbohydrate kinase activity
JS278_RS13315	COG0018	arginyl-trna synthetase
JS278_RS13325	COG2814	Major facilitator Superfamily
JS278_RS13330	COG2113	Glycine betaine
JS278_RS13335	COG2949	membrane
JS278_RS13340	COG0166	Belongs to the GPI family
JS278_RS13350	COG4581	dead DEAH box helicase
JS278_RS13360	COG1881	PFAM PEBP family protein
JS278_RS13380	COG0667	Aldo Keto reductase
JS278_RS13390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JS278_RS13395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JS278_RS13405	COG0148	phosphopyruvate hydratase activity
JS278_RS13470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JS278_RS13480	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
JS278_RS13485	COG0561	phosphatase activity
JS278_RS13490	COG0561	phosphatase activity
JS278_RS13515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JS278_RS13520	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JS278_RS13560	COG3559	Exporter of polyketide antibiotics
JS278_RS13565	COG1131	(ABC) transporter
JS278_RS13570	COG1113	amino acid transport
JS278_RS13580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JS278_RS13585	COG1695	Transcriptional regulator
JS278_RS13590	COG0477	Major facilitator Superfamily
JS278_RS13625	COG3311	Transcriptional regulator
JS278_RS13660	COG0438	transferase activity, transferring glycosyl groups
JS278_RS13670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JS278_RS13675	COG0489	protein tyrosine kinase activity
JS278_RS13695	COG1316	TRANSCRIPTIONal
JS278_RS13715	COG0604	alcohol dehydrogenase
JS278_RS13725	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JS278_RS13730	COG1088	dTDP-glucose 4,6-dehydratase activity
JS278_RS13740	COG1716	ATPase activity
JS278_RS13745	COG1716	ATPase activity
JS278_RS13760	COG0768	penicillin binding
JS278_RS13785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JS278_RS13790	COG0393	Putative heavy-metal-binding
JS278_RS13805	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JS278_RS13810	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JS278_RS13830	COG2186	Transcriptional regulator
JS278_RS13835	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JS278_RS13840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JS278_RS13865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JS278_RS13885	COG1609	Transcriptional regulator
JS278_RS13890	COG1175	transmembrane transport
JS278_RS13895	COG0395	ABC-type sugar transport system, permease component
JS278_RS13900	COG1653	transport
JS278_RS13910	COG1454	alcohol dehydrogenase
JS278_RS13915	COG0477	Major facilitator Superfamily
JS278_RS13945	COG1271	oxidase subunit
JS278_RS13950	COG1294	oxidase, subunit
JS278_RS13955	COG4988	ABC transporter
JS278_RS13960	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JS278_RS13970	COG1556	Lactate utilization protein
JS278_RS13975	COG1139	Iron-sulfur cluster binding protein
JS278_RS13980	COG0247	lactate metabolic process
JS278_RS13985	COG1620	l-lactate permease
JS278_RS13990	COG2186	Transcriptional regulator
JS278_RS14000	COG1013	pyruvate-flavodoxin oxidoreductase activity
JS278_RS14000	COG0674	pyruvate-flavodoxin oxidoreductase activity
JS278_RS14000	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JS278_RS14000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JS278_RS14005	COG0167	dihydroorotate dehydrogenase activity
JS278_RS14015	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JS278_RS14030	COG1937	Protein conserved in bacteria
JS278_RS14035	COG0305	Participates in initiation and elongation during chromosome replication
JS278_RS14040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JS278_RS14040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JS278_RS14070	COG3118	belongs to the thioredoxin family
JS278_RS14075	COG0492	ferredoxin-NADP+ reductase activity
JS278_RS14080	COG0386	Belongs to the glutathione peroxidase family
JS278_RS14105	COG2094	Belongs to the DNA glycosylase MPG family
JS278_RS14115	COG1643	Atp-dependent helicase
JS278_RS14130	COG2897	thiosulfate sulfurtransferase activity
JS278_RS14170	COG0463	Glycosyl transferase, family 2
JS278_RS14195	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JS278_RS14200	COG1126	abc transporter atp-binding protein
JS278_RS14205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JS278_RS14210	COG0765	amino acid transport
JS278_RS14215	COG0765	amino acid transport
JS278_RS14240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JS278_RS14240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JS278_RS14240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JS278_RS14275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JS278_RS14285	COG0438	transferase activity, transferring glycosyl groups
JS278_RS14290	COG0489	protein tyrosine kinase activity
JS278_RS14310	COG0438	transferase activity, transferring glycosyl groups
JS278_RS14315	COG0438	transferase activity, transferring glycosyl groups
JS278_RS14330	COG0463	Glycosyl transferase, family 2
JS278_RS14350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JS278_RS14385	COG1309	transcriptional regulator
JS278_RS14395	COG2130	NADP-dependent
JS278_RS14405	COG2801	Transposase and inactivated derivatives
JS278_RS14430	COG1396	sequence-specific DNA binding
JS278_RS14435	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
JS278_RS14445	COG3226	Transcriptional regulator
JS278_RS14455	COG2315	Protein conserved in bacteria
JS278_RS14460	COG1063	alcohol dehydrogenase
JS278_RS14495	COG2072	flavoprotein involved in K transport
JS278_RS14510	COG1247	-acetyltransferase
JS278_RS14520	COG1253	flavin adenine dinucleotide binding
JS278_RS14550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JS278_RS14560	COG1063	alcohol dehydrogenase
JS278_RS14580	COG1119	ATPase activity
JS278_RS14595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JS278_RS14600	COG3069	C4-dicarboxylate transmembrane transporter activity
JS278_RS14610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JS278_RS14625	COG1609	Transcriptional regulator
JS278_RS14630	COG0673	inositol 2-dehydrogenase activity
JS278_RS14635	COG2814	Major facilitator Superfamily
JS278_RS14640	COG1082	Xylose isomerase domain protein TIM barrel
JS278_RS14650	COG1609	Transcriptional regulator
JS278_RS14655	COG1129	ABC transporter
JS278_RS14660	COG1172	Belongs to the binding-protein-dependent transport system permease family
JS278_RS14710	COG1175	transmembrane transport
JS278_RS14715	COG0395	ABC-type sugar transport system, permease component
JS278_RS14725	COG0457	Tetratricopeptide repeat
JS278_RS14730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JS278_RS14740	COG5564	TIM-barrel signal transduction protein
JS278_RS14755	COG1482	cell wall glycoprotein biosynthetic process
JS278_RS14760	COG2814	Major facilitator Superfamily
JS278_RS14775	COG1070	Carbohydrate kinase
JS278_RS14825	COG0464	growth
JS278_RS14830	COG1396	sequence-specific DNA binding
JS278_RS14835	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
JS278_RS14855	COG1201	RNA secondary structure unwinding
JS278_RS14865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JS278_RS14930	COG1609	Transcriptional regulator
JS278_RS14940	COG1653	transport
JS278_RS14945	COG1175	transmembrane transport
JS278_RS14950	COG0395	ABC-type sugar transport system, permease component
JS278_RS14955	COG0584	glycerophosphoryl diester phosphodiesterase
JS278_RS14960	COG1609	Transcriptional regulator
JS278_RS14970	COG1285	pathogenesis
JS278_RS14975	COG0656	L-ascorbic acid biosynthetic process
JS278_RS15005	COG1609	Transcriptional regulator
JS278_RS15020	COG1172	Belongs to the binding-protein-dependent transport system permease family
JS278_RS15025	COG1172	Belongs to the binding-protein-dependent transport system permease family
JS278_RS15040	COG2814	Major facilitator Superfamily
JS278_RS15050	COG0673	inositol 2-dehydrogenase activity
JS278_RS15055	COG1609	Transcriptional regulator
JS278_RS15060	COG3386	PFAM SMP-30 Gluconolaconase
JS278_RS15065	COG0352	thiamine-phosphate diphosphorylase activity
JS278_RS15070	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JS278_RS15070	COG0352	thiamine-phosphate diphosphorylase activity
JS278_RS15070	COG0351	phosphomethylpyrimidine kinase
JS278_RS15095	COG0315	cyclic pyranopterin monophosphate synthase activity
JS278_RS15095	COG0521	Mo-molybdopterin cofactor biosynthetic process
JS278_RS15100	COG0315	cyclic pyranopterin monophosphate synthase activity
JS278_RS15115	COG0314	molybdopterin synthase activity
JS278_RS15145	COG1140	nitrate reductase beta subunit
JS278_RS15160	COG3657	addiction module killer protein
JS278_RS15165	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JS278_RS15175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JS278_RS15190	COG2337	Toxic component of a toxin-antitoxin (TA) module
JS278_RS15245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JS278_RS15260	COG0435	Glutathione S-transferase
JS278_RS15270	COG0456	acetyltransferase
JS278_RS15285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JS278_RS15295	COG2217	Heavy metal translocating P-type atpase
JS278_RS15330	COG0205	6-phosphofructokinase activity
JS278_RS15350	COG1136	(ABC) transporter
JS278_RS15395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JS278_RS15400	COG0045	succinate-CoA ligase (ADP-forming) activity
JS278_RS15400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JS278_RS15400	COG1042	CoA-binding domain protein
JS278_RS15405	COG1254	Belongs to the acylphosphatase family
JS278_RS15425	COG0281	malic enzyme
JS278_RS15430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JS278_RS15435	COG0477	Major facilitator Superfamily
JS278_RS15450	COG2814	Major facilitator Superfamily
JS278_RS15460	COG2197	response regulator
JS278_RS15485	COG0564	pseudouridine synthase activity
JS278_RS15490	COG3118	belongs to the thioredoxin family
JS278_RS15505	COG4585	Histidine kinase
JS278_RS15555	COG2826	transposase and inactivated derivatives, IS30 family
JS278_RS15560	COG1082	Xylose isomerase domain protein TIM barrel
JS278_RS15565	COG0673	inositol 2-dehydrogenase activity
JS278_RS15570	COG1609	Transcriptional regulator
JS278_RS15590	COG0477	Major facilitator Superfamily
JS278_RS15600	COG2855	membrane
JS278_RS15610	COG0673	inositol 2-dehydrogenase activity
JS278_RS15620	COG0673	inositol 2-dehydrogenase activity
JS278_RS15625	COG2814	Major facilitator Superfamily
JS278_RS15630	COG2814	Major facilitator Superfamily
JS278_RS15635	COG1609	Transcriptional regulator
JS278_RS15640	COG2814	Major facilitator Superfamily
JS278_RS15655	COG1082	Xylose isomerase domain protein TIM barrel
JS278_RS15660	COG0673	inositol 2-dehydrogenase activity
JS278_RS15670	COG1012	belongs to the aldehyde dehydrogenase family
JS278_RS15675	COG2188	Transcriptional regulator
JS278_RS15685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JS278_RS15690	COG1181	Belongs to the D-alanine--D-alanine ligase family
JS278_RS15705	COG3285	dna ligase
JS278_RS15705	COG1793	dna ligase
JS278_RS15720	COG0357	Ribosomal RNA small subunit methyltransferase G
JS278_RS15735	COG0706	membrane insertase activity
JS278_RS15745	COG0594	ribonuclease P activity