locus-tag	class	description
A5904_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A5904_RS00010	COG0592	DNA-directed DNA polymerase activity
A5904_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A5904_RS00020	COG0187	DNA topoisomerase II activity
A5904_RS00025	COG0493	'glutamate synthase
A5904_RS00025	COG0543	2 iron, 2 sulfur cluster binding
A5904_RS00030	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A5904_RS00040	COG0850	regulation of cytokinetic process
A5904_RS00045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A5904_RS00050	COG1754	DNA topoisomerase type I activity
A5904_RS00050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A5904_RS00055	COG2922	Belongs to the Smg family
A5904_RS00060	COG0758	DNA mediated transformation
A5904_RS00070	COG0242	peptide deformylase activity
A5904_RS00075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A5904_RS00080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A5904_RS00080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A5904_RS00085	COG5000	phosphorelay sensor kinase activity
A5904_RS00090	COG2204	response regulator
A5904_RS00095	COG0521	Mo-molybdopterin cofactor biosynthetic process
A5904_RS00105	COG0445	tRNA wobble uridine modification
A5904_RS00110	COG0357	Ribosomal RNA small subunit methyltransferase G
A5904_RS00120	COG1475	DNA binding
A5904_RS00130	COG0356	it plays a direct role in the translocation of protons across the membrane
A5904_RS00140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A5904_RS00145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A5904_RS00150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A5904_RS00155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A5904_RS00170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A5904_RS00265	COG0210	DNA helicase
A5904_RS00295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A5904_RS00310	COG1970	mechanosensitive ion channel activity
A5904_RS00315	COG1322	Protein conserved in bacteria
A5904_RS00320	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A5904_RS00330	COG0483	inositol monophosphate 1-phosphatase activity
A5904_RS00335	COG1494	fructose-1,6-bisphosphatase
A5904_RS00340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A5904_RS00345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A5904_RS00350	COG0126	phosphoglycerate kinase activity
A5904_RS00355	COG0469	pyruvate kinase activity
A5904_RS00365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A5904_RS00370	COG0546	phosphoglycolate phosphatase activity
A5904_RS00380	COG0512	Glutamine amidotransferase of anthranilate synthase
A5904_RS00385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A5904_RS00390	COG0134	indole-3-glycerol-phosphate synthase activity
A5904_RS00405	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
A5904_RS00415	COG2945	thiolester hydrolase activity
A5904_RS00420	COG1131	(ABC) transporter
A5904_RS00450	COG4942	peptidase
A5904_RS00475	COG3668	Plasmid stabilization system
A5904_RS00530	COG1484	DNA-dependent DNA replication
A5904_RS00565	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A5904_RS00625	COG0438	transferase activity, transferring glycosyl groups
A5904_RS00645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A5904_RS00670	COG1215	transferase activity, transferring glycosyl groups
A5904_RS00700	COG1461	Dihydroxyacetone kinase
A5904_RS00705	COG2376	Dihydroxyacetone kinase
A5904_RS00730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A5904_RS00745	COG0359	binds to the 23S rRNA
A5904_RS00755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A5904_RS00760	COG0360	Binds together with S18 to 16S ribosomal RNA
A5904_RS00765	COG1472	Belongs to the glycosyl hydrolase 3 family
A5904_RS00770	COG0531	amino acid
A5904_RS00780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A5904_RS00805	COG0363	glucosamine-6-phosphate deaminase activity
A5904_RS00820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A5904_RS00835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A5904_RS00840	COG1074	ATP-dependent DNA helicase activity
A5904_RS00845	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A5904_RS00855	COG3220	belongs to the UPF0276 family
A5904_RS00870	COG2204	response regulator
A5904_RS00880	COG2205	protein histidine kinase activity
A5904_RS00885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A5904_RS00890	COG0540	Belongs to the ATCase OTCase family
A5904_RS00895	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A5904_RS00905	COG1678	Uncharacterized ACR, COG1678
A5904_RS00910	COG0189	ligase activity
A5904_RS00925	COG0316	Belongs to the HesB IscA family
A5904_RS00945	COG3431	PFAM Phosphate-starvation-inducible E
A5904_RS00955	COG0022	dehydrogenase e1 component
A5904_RS00955	COG0508	dehydrogenase complex catalyzes the overall conversion of
A5904_RS00960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A5904_RS00970	COG3273	potassium ion transport
A5904_RS00970	COG0471	metal ion transport
A5904_RS00975	COG0745	RESPONSE REGULATOR receiver
A5904_RS00980	COG2205	protein histidine kinase activity
A5904_RS00990	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A5904_RS01000	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A5904_RS01010	COG0415	Belongs to the DNA photolyase family
A5904_RS01020	COG2814	Major facilitator Superfamily
A5904_RS01055	COG2226	methyltransferase
A5904_RS01060	COG2967	ApaG domain
A5904_RS01065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A5904_RS01090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A5904_RS01095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A5904_RS01110	COG0436	Aminotransferase
A5904_RS01120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A5904_RS01130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A5904_RS01135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A5904_RS01140	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A5904_RS01145	COG4591	ABC-type transport system involved in lipoprotein release permease component
A5904_RS01150	COG1136	(ABC) transporter
A5904_RS01160	COG0658	competence protein
A5904_RS01160	COG2333	competence protein COMEC
A5904_RS01170	COG0848	biopolymer transport protein
A5904_RS01185	COG1663	tetraacyldisaccharide 4'-kinase activity
A5904_RS01190	COG2835	tetraacyldisaccharide 4'-kinase activity
A5904_RS01195	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A5904_RS01215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A5904_RS01225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A5904_RS01230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A5904_RS01245	COG0330	HflC and HflK could
A5904_RS01255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A5904_RS01265	COG2814	Major facilitator Superfamily
A5904_RS01290	COG0805	protein transport
A5904_RS01295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A5904_RS01300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A5904_RS01305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A5904_RS01305	COG0140	phosphoribosyl-ATP diphosphatase activity
A5904_RS01310	COG0107	imidazoleglycerol-phosphate synthase activity
A5904_RS01315	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A5904_RS01320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A5904_RS01325	COG0131	Imidazoleglycerol-phosphate dehydratase
A5904_RS01330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A5904_RS01340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A5904_RS01345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A5904_RS01350	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A5904_RS01360	COG0842	Transport permease protein
A5904_RS01365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A5904_RS01400	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A5904_RS01410	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A5904_RS01430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A5904_RS01430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A5904_RS01430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A5904_RS01435	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A5904_RS01440	COG1660	Displays ATPase and GTPase activities
A5904_RS01455	COG1376	ErfK ybiS ycfS ynhG family protein
A5904_RS01465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A5904_RS01475	COG0297	glycogen (starch) synthase activity
A5904_RS01510	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A5904_RS01515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A5904_RS01525	COG2204	response regulator
A5904_RS01545	COG0497	DNA recombination
A5904_RS01550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A5904_RS01555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A5904_RS01560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A5904_RS01575	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A5904_RS01605	COG0114	fumarate hydratase activity
A5904_RS01610	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A5904_RS01620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A5904_RS01620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A5904_RS01625	COG0006	proline dipeptidase activity
A5904_RS01645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A5904_RS01660	COG0495	leucyl-tRNA aminoacylation
A5904_RS01665	COG1534	Rna-binding protein
A5904_RS01670	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A5904_RS01705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A5904_RS01770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A5904_RS01775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A5904_RS01780	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A5904_RS01790	COG1294	oxidase, subunit
A5904_RS01800	COG1271	oxidase subunit
A5904_RS01810	COG0166	Belongs to the GPI family
A5904_RS01815	COG1686	Belongs to the peptidase S11 family
A5904_RS01820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A5904_RS01845	COG0642	Histidine kinase
A5904_RS01860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A5904_RS01870	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A5904_RS01890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A5904_RS01895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A5904_RS01900	COG2890	protein-(glutamine-N5) methyltransferase activity
A5904_RS01905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A5904_RS01910	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A5904_RS01915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A5904_RS01925	COG0116	Belongs to the methyltransferase superfamily
A5904_RS01925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A5904_RS01930	COG0552	protein localization to endoplasmic reticulum
A5904_RS01935	COG2884	Cell division ATP-binding protein ftsE
A5904_RS01940	COG2177	Part of the ABC transporter FtsEX involved in
A5904_RS01955	COG3264	Mechanosensitive ion channel
A5904_RS01955	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A5904_RS01960	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A5904_RS01970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A5904_RS01980	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A5904_RS01990	COG4221	oxidoreductase activity
A5904_RS02015	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A5904_RS02045	COG1215	transferase activity, transferring glycosyl groups
A5904_RS02065	COG0513	Belongs to the DEAD box helicase family
A5904_RS02070	COG1278	Cold shock
A5904_RS02090	COG1484	DNA-dependent DNA replication
A5904_RS02140	COG1215	transferase activity, transferring glycosyl groups
A5904_RS02160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A5904_RS02165	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A5904_RS02175	COG1230	cation diffusion facilitator family transporter
A5904_RS02180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A5904_RS02185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A5904_RS02195	COG1449	Belongs to the glycosyl hydrolase 57 family
A5904_RS02200	COG1940	carbohydrate kinase activity
A5904_RS02215	COG2733	membrane
A5904_RS02225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A5904_RS02230	COG1702	phosphate starvation-inducible protein PhoH
A5904_RS02235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A5904_RS02240	COG4535	Mg2 and Co2 transporter CorC
A5904_RS02245	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A5904_RS02290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A5904_RS02295	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A5904_RS02310	COG3220	belongs to the UPF0276 family
A5904_RS02330	COG4232	protein-disulfide reductase activity
A5904_RS02350	COG2814	Major facilitator Superfamily
A5904_RS02360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A5904_RS02360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A5904_RS02375	COG2226	methyltransferase
A5904_RS02425	COG0033	Phosphoglucomutase
A5904_RS02440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A5904_RS02445	COG0228	four-way junction DNA binding
A5904_RS02450	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A5904_RS02455	COG0336	Belongs to the RNA methyltransferase TrmD family
A5904_RS02460	COG0335	large ribosomal subunit rRNA binding
A5904_RS02480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A5904_RS02485	COG3118	belongs to the thioredoxin family
A5904_RS02500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A5904_RS02505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A5904_RS02510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A5904_RS02510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A5904_RS02525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A5904_RS02530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A5904_RS02545	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A5904_RS02570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A5904_RS02575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A5904_RS02585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A5904_RS02595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A5904_RS02600	COG0081	regulation of translation
A5904_RS02605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A5904_RS02610	COG0222	ribosome binding
A5904_RS02615	COG0085	RNA polymerase activity
A5904_RS02620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A5904_RS02625	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A5904_RS02630	COG0049	tRNA binding
A5904_RS02635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A5904_RS02640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A5904_RS02645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A5904_RS02650	COG0051	transcription antitermination factor activity, RNA binding
A5904_RS02655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A5904_RS02660	COG0088	Forms part of the polypeptide exit tunnel
A5904_RS02665	COG0089	rRNA binding
A5904_RS02670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A5904_RS02675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A5904_RS02680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A5904_RS02690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A5904_RS02695	COG0255	Belongs to the universal ribosomal protein uL29 family
A5904_RS02700	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A5904_RS02705	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A5904_RS02710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A5904_RS02715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A5904_RS02720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A5904_RS02725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A5904_RS02730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A5904_RS02735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A5904_RS02740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A5904_RS02745	COG1841	ribosomal large subunit assembly
A5904_RS02750	COG0200	Binds to the 23S rRNA
A5904_RS02755	COG0201	protein transport
A5904_RS02760	COG0563	adenylate kinase activity
A5904_RS02765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A5904_RS02770	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A5904_RS02775	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A5904_RS02780	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A5904_RS02785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A5904_RS02790	COG0202	RNA polymerase activity
A5904_RS02795	COG0203	ribosomal protein L17
A5904_RS02805	COG0629	single-stranded DNA binding
A5904_RS02820	COG0312	modulator of DNA gyrase
A5904_RS02825	COG0617	tRNA 3'-terminal CCA addition
A5904_RS02830	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A5904_RS02835	COG0066	3-isopropylmalate dehydratase activity
A5904_RS02845	COG0259	pyridoxamine-phosphate oxidase activity
A5904_RS02850	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A5904_RS02860	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A5904_RS02865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A5904_RS02870	COG1845	cytochrome c oxidase, subunit III
A5904_RS02885	COG0109	protoheme IX farnesyltransferase activity
A5904_RS02890	COG2814	Major facilitator Superfamily
A5904_RS02895	COG1968	undecaprenyl-diphosphatase activity
A5904_RS02900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A5904_RS02910	COG0505	Belongs to the CarA family
A5904_RS02930	COG0531	amino acid
A5904_RS02935	COG0142	geranyltranstransferase activity
A5904_RS02960	COG0488	(ABC) transporter
A5904_RS02970	COG1573	uracil-dna glycosylase
A5904_RS02975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A5904_RS02980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A5904_RS02990	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A5904_RS03020	COG0811	peptide transport
A5904_RS03045	COG0768	penicillin binding
A5904_RS03060	COG0167	dihydroorotate dehydrogenase activity
A5904_RS03065	COG0408	coproporphyrinogen oxidase activity
A5904_RS03070	COG0009	L-threonylcarbamoyladenylate synthase
A5904_RS03075	COG0151	Belongs to the GarS family
A5904_RS03080	COG0138	bifunctional purine biosynthesis protein purh
A5904_RS03085	COG1979	alcohol dehydrogenase
A5904_RS03090	COG0012	GTP binding
A5904_RS03095	COG0193	aminoacyl-tRNA hydrolase activity
A5904_RS03100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A5904_RS03105	COG0768	penicillin binding
A5904_RS03125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A5904_RS03130	COG1692	metallophosphoesterase
A5904_RS03145	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A5904_RS03185	COG0589	response to stress
A5904_RS03190	COG0442	prolyl-tRNA aminoacylation
A5904_RS03215	COG1271	oxidase subunit
A5904_RS03225	COG0531	amino acid
A5904_RS03235	COG0525	valine-tRNA ligase activity
A5904_RS03250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A5904_RS03265	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A5904_RS03285	COG1965	Belongs to the frataxin family
A5904_RS03290	COG0514	ATP-dependent DNA helicase (RecQ)
A5904_RS03300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A5904_RS03310	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A5904_RS03315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A5904_RS03320	COG3852	Histidine kinase
A5904_RS03325	COG2204	response regulator
A5904_RS03350	COG3550	peptidyl-serine autophosphorylation
A5904_RS03415	COG0822	iron-sulfur transferase activity
A5904_RS03445	COG3604	Transcriptional regulator
A5904_RS03510	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A5904_RS03515	COG0268	Binds directly to 16S ribosomal RNA
A5904_RS03530	COG2957	Belongs to the agmatine deiminase family
A5904_RS03535	COG1187	pseudouridine synthase activity
A5904_RS03545	COG0494	nUDIX hydrolase
A5904_RS03570	COG0254	rRNA binding
A5904_RS03575	COG0281	malic enzyme
A5904_RS03580	COG0129	dihydroxy-acid dehydratase activity
A5904_RS03590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A5904_RS03590	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A5904_RS03600	COG2350	Protein conserved in bacteria
A5904_RS03605	COG2917	probably involved in intracellular septation
A5904_RS03620	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A5904_RS03630	COG1959	2 iron, 2 sulfur cluster binding
A5904_RS03635	COG1104	cysteine desulfurase activity
A5904_RS03640	COG0822	iron-sulfur transferase activity
A5904_RS03645	COG0316	Belongs to the HesB IscA family
A5904_RS03650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A5904_RS03655	COG0443	Heat shock 70 kDa protein
A5904_RS03670	COG0482	sulfurtransferase activity
A5904_RS03685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A5904_RS03690	COG0704	Plays a role in the regulation of phosphate uptake
A5904_RS03695	COG0248	Ppx GppA phosphatase
A5904_RS03705	COG0052	Belongs to the universal ribosomal protein uS2 family
A5904_RS03710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A5904_RS03715	COG0528	UMP kinase activity
A5904_RS03725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A5904_RS03730	COG0575	Belongs to the CDS family
A5904_RS03735	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A5904_RS03755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A5904_RS03760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A5904_RS03765	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A5904_RS03780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A5904_RS03785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A5904_RS03795	COG0825	malonyl-CoA metabolic process
A5904_RS03800	COG0037	tRNA processing
A5904_RS03845	COG1132	(ABC) transporter
A5904_RS03865	COG1592	Rubrerythrin
A5904_RS03880	COG1570	exodeoxyribonuclease VII activity
A5904_RS03885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A5904_RS03910	COG0741	lytic transglycosylase activity
A5904_RS03920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A5904_RS03930	COG1121	(ABC) transporter
A5904_RS03935	COG2223	nitrite transmembrane transporter activity
A5904_RS03940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A5904_RS04010	COG3039	Transposase
A5904_RS04025	COG3039	Transposase
A5904_RS04040	COG0616	signal peptide processing
A5904_RS04045	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A5904_RS04050	COG0314	molybdopterin synthase activity
A5904_RS04055	COG1666	GTP binding
A5904_RS04070	COG0509	glycine decarboxylation via glycine cleavage system
A5904_RS04075	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A5904_RS04085	COG0714	Associated with various cellular activities
A5904_RS04100	COG1132	(ABC) transporter
A5904_RS04105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A5904_RS04115	COG0450	alkyl hydroperoxide reductase
A5904_RS04125	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A5904_RS04140	COG1850	ribulose-bisphosphate carboxylase activity
A5904_RS04145	COG4451	ribulose bisphosphate carboxylase, small
A5904_RS04170	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A5904_RS04175	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A5904_RS04180	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A5904_RS04210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A5904_RS04240	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A5904_RS04255	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A5904_RS04255	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A5904_RS04255	COG0506	proline dehydrogenase activity
A5904_RS04270	COG0640	Transcriptional regulator
A5904_RS04275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A5904_RS04280	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A5904_RS04290	COG0436	Aminotransferase
A5904_RS04330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A5904_RS04345	COG2814	Major facilitator Superfamily
A5904_RS04350	COG1686	Belongs to the peptidase S11 family
A5904_RS04375	COG0418	dihydroorotase activity
A5904_RS04390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A5904_RS04425	COG0697	spore germination
A5904_RS04430	COG1902	pentaerythritol trinitrate reductase activity
A5904_RS04525	COG0557	exoribonuclease II activity
A5904_RS04550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A5904_RS04555	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A5904_RS04570	COG1295	ribonuclease BN
A5904_RS04580	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A5904_RS04585	COG0416	fatty acid biosynthetic process
A5904_RS04590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A5904_RS04595	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A5904_RS04605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A5904_RS04610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A5904_RS04620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A5904_RS04625	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A5904_RS04630	COG0470	DNA polymerase III
A5904_RS04795	COG0583	DNA-binding transcription factor activity
A5904_RS04800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A5904_RS04805	COG3002	Belongs to the UPF0753 family
A5904_RS04820	COG0129	dihydroxy-acid dehydratase activity
A5904_RS04825	COG0009	L-threonylcarbamoyladenylate synthase
A5904_RS04885	COG2433	Pfam Transposase IS66
A5904_RS04890	COG3436	PFAM IS66 Orf2 family protein
A5904_RS04905	COG2433	Pfam Transposase IS66
A5904_RS04910	COG3436	PFAM IS66 Orf2 family protein
A5904_RS04920	COG1484	DNA-dependent DNA replication
A5904_RS04945	COG1484	DNA-dependent DNA replication
A5904_RS04955	COG1484	DNA-dependent DNA replication
A5904_RS04970	COG4232	protein-disulfide reductase activity
A5904_RS05010	COG3220	belongs to the UPF0276 family
A5904_RS05030	COG0842	Transport permease protein
A5904_RS05035	COG0842	Transport permease protein
A5904_RS05040	COG1131	(ABC) transporter
A5904_RS05050	COG1538	Outer membrane efflux protein
A5904_RS05060	COG0789	Transcriptional regulator
A5904_RS05095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A5904_RS05100	COG3002	Belongs to the UPF0753 family
A5904_RS05105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A5904_RS05110	COG0583	DNA-binding transcription factor activity
A5904_RS05115	COG3706	GGDEF domain
A5904_RS05120	COG2353	YceI-like domain
A5904_RS05125	COG0655	NAD(P)H dehydrogenase (quinone) activity
A5904_RS05130	COG1733	regulation of RNA biosynthetic process
A5904_RS05225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A5904_RS05245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A5904_RS05250	COG3707	response regulator
A5904_RS05260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A5904_RS05260	COG1648	precorrin-2 dehydrogenase activity
A5904_RS05265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A5904_RS05270	COG0243	molybdopterin cofactor binding
A5904_RS05275	COG2146	nitrite reductase [NAD(P)H] activity
A5904_RS05280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A5904_RS05295	COG2223	nitrite transmembrane transporter activity
A5904_RS05300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A5904_RS05300	COG1116	anion transmembrane transporter activity
A5904_RS05380	COG1484	DNA-dependent DNA replication
A5904_RS05400	COG1484	DNA-dependent DNA replication
A5904_RS05410	COG1484	DNA-dependent DNA replication
A5904_RS05445	COG2755	lipolytic protein G-D-S-L family
A5904_RS05445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A5904_RS05460	COG1484	DNA-dependent DNA replication
A5904_RS05525	COG0629	single-stranded DNA binding
A5904_RS05605	COG4962	Type ii secretion system protein e
A5904_RS05635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A5904_RS05700	COG3451	type IV secretory pathway VirB4
A5904_RS05710	COG1598	PFAM Uncharacterised protein family UPF0150
A5904_RS05780	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A5904_RS05830	COG3701	Conjugal transfer protein
A5904_RS05840	COG2948	multi-organism process
A5904_RS05850	COG1192	Involved in chromosome partitioning
A5904_RS05855	COG1475	DNA binding
A5904_RS05875	COG3561	AntA/AntB antirepressor
A5904_RS05940	COG1484	DNA-dependent DNA replication
A5904_RS06105	COG0741	lytic transglycosylase activity
A5904_RS06255	COG0582	viral genome integration into host DNA
A5904_RS06285	COG0729	surface antigen
A5904_RS06300	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A5904_RS06305	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A5904_RS06310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A5904_RS06315	COG0004	ammonium transporteR
A5904_RS06320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A5904_RS06320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A5904_RS06325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A5904_RS06330	COG2239	Acts as a magnesium transporter
A5904_RS06335	COG0802	atpase or kinase
A5904_RS06345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A5904_RS06370	COG0393	Putative heavy-metal-binding
A5904_RS06390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A5904_RS06400	COG0429	hydrolase of the alpha beta-hydrolase fold
A5904_RS06410	COG2373	Large extracellular alpha-helical protein
A5904_RS06415	COG4953	penicillin-binding protein 1C
A5904_RS06420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A5904_RS06425	COG0508	dehydrogenase complex catalyzes the overall conversion of
A5904_RS06430	COG0022	dehydrogenase e1 component
A5904_RS06435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A5904_RS06445	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A5904_RS06450	COG0574	Belongs to the PEP-utilizing enzyme family
A5904_RS06450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A5904_RS06465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A5904_RS06470	COG2171	N-acyltransferase activity
A5904_RS06475	COG0436	Aminotransferase
A5904_RS06485	COG0546	phosphoglycolate phosphatase activity
A5904_RS06495	COG0402	S-adenosylhomocysteine deaminase activity
A5904_RS06505	COG1388	LysM domain
A5904_RS06505	COG0791	NLP P60 protein
A5904_RS06545	COG2271	Major facilitator Superfamily
A5904_RS06550	COG0438	transferase activity, transferring glycosyl groups
A5904_RS06560	COG0745	RESPONSE REGULATOR receiver
A5904_RS06565	COG0811	peptide transport
A5904_RS06595	COG3842	ATPase activity
A5904_RS06615	COG1566	PFAM secretion protein HlyD family protein
A5904_RS06625	COG2132	Multicopper oxidase
A5904_RS06630	COG0105	UTP biosynthetic process
A5904_RS06635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A5904_RS06650	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A5904_RS06655	COG0124	histidyl-tRNA synthetase
A5904_RS06665	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A5904_RS06670	COG1160	GTP binding
A5904_RS06720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A5904_RS06725	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A5904_RS06740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A5904_RS06750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A5904_RS06755	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A5904_RS06760	COG0287	Prephenate dehydrogenase
A5904_RS06765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A5904_RS06770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A5904_RS06780	COG0776	regulation of translation
A5904_RS06785	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A5904_RS06795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A5904_RS06800	COG0544	peptidyl-prolyl cis-trans isomerase activity
A5904_RS06805	COG0740	serine-type endopeptidase activity
A5904_RS06810	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A5904_RS06815	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A5904_RS06835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A5904_RS06855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A5904_RS06865	COG5001	Diguanylate cyclase
A5904_RS06865	COG3447	MASE1 domain protein
A5904_RS06865	COG5002	protein histidine kinase activity
A5904_RS06950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A5904_RS06955	COG0215	cysteine-tRNA ligase activity
A5904_RS06960	COG1530	ribonuclease E activity
A5904_RS06970	COG0546	phosphoglycolate phosphatase activity
A5904_RS06980	COG3842	ATPase activity
A5904_RS06990	COG0446	pyridine nucleotide-disulphide oxidoreductase
A5904_RS07005	COG1028	Short-chain dehydrogenase reductase Sdr
A5904_RS07010	COG0616	signal peptide processing
A5904_RS07015	COG0667	Aldo Keto reductase
A5904_RS07030	COG0840	transmembrane signaling receptor activity
A5904_RS07035	COG0784	Response regulator, receiver
A5904_RS07035	COG0835	chemotaxis
A5904_RS07050	COG2198	Histidine kinase
A5904_RS07050	COG0784	Response regulator, receiver
A5904_RS07050	COG0643	Histidine kinase
A5904_RS07060	COG0745	RESPONSE REGULATOR receiver
A5904_RS07080	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A5904_RS07105	COG1815	bacterial-type flagellum-dependent cell motility
A5904_RS07110	COG1558	bacterial-type flagellum-dependent cell motility
A5904_RS07135	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A5904_RS07140	COG1706	bacterial-type flagellum-dependent cell motility
A5904_RS07145	COG1705	Flagellar rod assembly protein muramidase FlgJ
A5904_RS07145	COG3951	Flagellar rod assembly protein muramidase FlgJ
A5904_RS07155	COG1256	bacterial-type flagellum assembly
A5904_RS07165	COG1216	Glycosyl transferase, family 2
A5904_RS07165	COG0438	transferase activity, transferring glycosyl groups
A5904_RS07200	COG3852	Histidine kinase
A5904_RS07210	COG1677	Flagellar hook-basal body complex protein FliE
A5904_RS07220	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A5904_RS07260	COG1338	Plays a role in the flagellum-specific transport system
A5904_RS07265	COG1987	bacterial-type flagellum assembly
A5904_RS07280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A5904_RS07295	COG1191	sigma factor activity
A5904_RS07300	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A5904_RS07305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A5904_RS07310	COG0670	Belongs to the BI1 family
A5904_RS07330	COG0277	FAD linked oxidase domain protein
A5904_RS07335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A5904_RS07340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A5904_RS07345	COG1428	Deoxynucleoside kinase
A5904_RS07355	COG0617	tRNA 3'-terminal CCA addition
A5904_RS07365	COG0519	Catalyzes the synthesis of GMP from XMP
A5904_RS07375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A5904_RS07375	COG1017	nitric oxide dioxygenase activity
A5904_RS07400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A5904_RS07400	COG1017	nitric oxide dioxygenase activity
A5904_RS07420	COG3189	MarR family transcriptional regulator
A5904_RS07425	COG0477	Major facilitator Superfamily
A5904_RS07445	COG2814	Major facilitator Superfamily
A5904_RS07455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A5904_RS07480	COG1105	Belongs to the carbohydrate kinase PfkB family
A5904_RS07485	COG0280	phosphate acetyltransferase
A5904_RS07520	COG1914	H( )-stimulated, divalent metal cation uptake system
A5904_RS07525	COG1285	pathogenesis
A5904_RS07545	COG3657	addiction module killer protein
A5904_RS07550	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A5904_RS07650	COG1484	DNA-dependent DNA replication
A5904_RS07720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A5904_RS07725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A5904_RS07765	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A5904_RS07815	COG1271	oxidase subunit
A5904_RS07820	COG1294	oxidase, subunit
A5904_RS07830	COG0243	molybdopterin cofactor binding
A5904_RS07835	COG0437	4 iron, 4 sulfur cluster binding
A5904_RS07845	COG0437	4 iron, 4 sulfur cluster binding
A5904_RS07850	COG3302	dmso reductase anchor subunit
A5904_RS07880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A5904_RS07900	COG3436	PFAM IS66 Orf2 family protein
A5904_RS07905	COG2433	Pfam Transposase IS66
A5904_RS07965	COG0741	lytic transglycosylase activity
A5904_RS07990	COG2943	transferase activity, transferring hexosyl groups
A5904_RS08050	COG2433	Pfam Transposase IS66
A5904_RS08055	COG3436	PFAM IS66 Orf2 family protein
A5904_RS08065	COG1113	amino acid transport
A5904_RS08080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A5904_RS08110	COG2814	Major facilitator Superfamily
A5904_RS08115	COG4654	Cytochrome c, class I
A5904_RS08135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A5904_RS08150	COG0243	molybdopterin cofactor binding
A5904_RS08155	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A5904_RS08160	COG1166	arginine decarboxylase activity
A5904_RS08165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A5904_RS08170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A5904_RS08185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A5904_RS08190	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A5904_RS08205	COG1850	ribulose-bisphosphate carboxylase activity
A5904_RS08245	COG0651	ATP synthesis coupled electron transport
A5904_RS08250	COG0649	NAD binding
A5904_RS08250	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS08250	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS08255	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS08270	COG0076	glutamate decarboxylase activity
A5904_RS08275	COG0163	prenyltransferase activity
A5904_RS08280	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A5904_RS08290	COG2022	thiamine diphosphate biosynthetic process
A5904_RS08320	COG2137	regulation of response to DNA damage stimulus
A5904_RS08325	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A5904_RS08330	COG1058	Belongs to the CinA family
A5904_RS08330	COG1546	Belongs to the CinA family
A5904_RS08340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A5904_RS08355	COG1489	DNA binding
A5904_RS08360	COG0024	Methionine aminopeptidase
A5904_RS08370	COG2915	High frequency lysogenization protein hflD homolog
A5904_RS08385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A5904_RS08395	COG1196	nuclear chromosome segregation
A5904_RS08400	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A5904_RS08405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A5904_RS08415	COG1187	pseudouridine synthase activity
A5904_RS08420	COG0446	pyridine nucleotide-disulphide oxidoreductase
A5904_RS08425	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A5904_RS08430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A5904_RS08435	COG0180	Tryptophanyl-tRNA synthetase
A5904_RS08440	COG1994	Peptidase M50
A5904_RS08445	COG0009	L-threonylcarbamoyladenylate synthase
A5904_RS08450	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A5904_RS08460	COG3264	Mechanosensitive ion channel
A5904_RS08460	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A5904_RS08465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A5904_RS08490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A5904_RS08490	COG2205	protein histidine kinase activity
A5904_RS08495	COG0587	DNA-directed DNA polymerase activity
A5904_RS08510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A5904_RS08520	COG2860	membrane
A5904_RS08535	COG0438	transferase activity, transferring glycosyl groups
A5904_RS08540	COG0438	transferase activity, transferring glycosyl groups
A5904_RS08545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A5904_RS08565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A5904_RS08570	COG0196	riboflavin kinase activity
A5904_RS08575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A5904_RS08580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A5904_RS08590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A5904_RS08600	COG4178	(ABC) transporter
A5904_RS08610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A5904_RS08615	COG0860	N-Acetylmuramoyl-L-alanine amidase
A5904_RS08620	COG3118	belongs to the thioredoxin family
A5904_RS08630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A5904_RS08630	COG0425	Belongs to the sulfur carrier protein TusA family
A5904_RS08655	COG0640	Transcriptional regulator
A5904_RS08665	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A5904_RS08680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A5904_RS08685	COG0084	hydrolase, TatD family'
A5904_RS08690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A5904_RS08695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A5904_RS08715	COG1183	phosphatidylcholine synthase activity
A5904_RS08720	COG0688	phosphatidylethanolamine metabolic process
A5904_RS08725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A5904_RS08735	COG0028	Belongs to the TPP enzyme family
A5904_RS08740	COG1193	negative regulation of DNA recombination
A5904_RS08750	COG0432	Pfam Uncharacterised protein family UPF0047
A5904_RS08785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A5904_RS08790	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A5904_RS08795	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A5904_RS08800	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A5904_RS08805	COG0067	glutamate synthase
A5904_RS08805	COG0069	glutamate synthase activity
A5904_RS08805	COG0070	glutamate synthase
A5904_RS08810	COG0493	'glutamate synthase
A5904_RS08815	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A5904_RS08835	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A5904_RS08840	COG0330	HflC and HflK could
A5904_RS08845	COG0330	HflC and HflK could
A5904_RS08850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A5904_RS08855	COG1923	regulation of RNA biosynthetic process
A5904_RS08860	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A5904_RS08865	COG0424	maF-like protein
A5904_RS08930	COG2433	Pfam Transposase IS66
A5904_RS08935	COG3436	PFAM IS66 Orf2 family protein
A5904_RS08970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A5904_RS08980	COG0640	Transcriptional regulator
A5904_RS09050	COG0463	Glycosyl transferase, family 2
A5904_RS09070	COG1403	HNH endonuclease
A5904_RS09090	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A5904_RS09110	COG0322	excinuclease ABC activity
A5904_RS09120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A5904_RS09130	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A5904_RS09135	COG0148	phosphopyruvate hydratase activity
A5904_RS09140	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A5904_RS09145	COG0504	CTP synthase activity
A5904_RS09305	COG2948	multi-organism process
A5904_RS09340	COG0513	Belongs to the DEAD box helicase family
A5904_RS09355	COG0347	Belongs to the P(II) protein family
A5904_RS09360	COG0505	Belongs to the CarA family
A5904_RS09370	COG0004	ammonium transporteR
A5904_RS09405	COG3852	Histidine kinase
A5904_RS09475	COG1937	Protein conserved in bacteria
A5904_RS09485	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A5904_RS09520	COG2217	Heavy metal translocating P-type atpase
A5904_RS09575	COG2226	methyltransferase
A5904_RS09590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A5904_RS09590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A5904_RS09600	COG2814	Major facilitator Superfamily
A5904_RS09635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A5904_RS09635	COG1017	nitric oxide dioxygenase activity
A5904_RS09650	COG1017	nitric oxide dioxygenase activity
A5904_RS09650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A5904_RS09670	COG0509	glycine decarboxylation via glycine cleavage system
A5904_RS09705	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A5904_RS09720	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A5904_RS09725	COG1140	nitrate reductase beta subunit
A5904_RS09730	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A5904_RS09735	COG2181	nitrate reductase activity
A5904_RS09745	COG2223	nitrite transmembrane transporter activity
A5904_RS09750	COG3189	MarR family transcriptional regulator
A5904_RS09770	COG1484	DNA-dependent DNA replication
A5904_RS09780	COG1484	DNA-dependent DNA replication
A5904_RS09790	COG0477	Major facilitator Superfamily
A5904_RS09795	COG0583	DNA-binding transcription factor activity
A5904_RS09845	COG0084	hydrolase, TatD family'
A5904_RS09850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A5904_RS09860	COG0628	permease
A5904_RS09865	COG0613	PHP domain protein
A5904_RS09875	COG0628	permease
A5904_RS09890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A5904_RS09905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A5904_RS09910	COG1758	RNA polymerase activity
A5904_RS09920	COG1561	YicC-like family, N-terminal region
A5904_RS09925	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A5904_RS09940	COG4232	protein-disulfide reductase activity
A5904_RS09945	COG1324	tolerance protein
A5904_RS09975	COG2390	Transcriptional regulator
A5904_RS09975	COG4584	PFAM Integrase catalytic
A5904_RS10005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A5904_RS10015	COG0582	viral genome integration into host DNA
A5904_RS10120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A5904_RS10125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A5904_RS10130	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A5904_RS10145	COG3025	triphosphatase activity
A5904_RS10155	COG0308	aminopeptidase N
A5904_RS10165	COG0542	response to heat
A5904_RS10170	COG2211	Major facilitator Superfamily
A5904_RS10175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A5904_RS10180	COG1469	GTP cyclohydrolase I activity
A5904_RS10185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A5904_RS10190	COG0142	geranyltranstransferase activity
A5904_RS10200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A5904_RS10205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A5904_RS10210	COG1862	Preprotein translocase
A5904_RS10215	COG0343	queuine tRNA-ribosyltransferase activity
A5904_RS10220	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A5904_RS10225	COG1253	flavin adenine dinucleotide binding
A5904_RS10240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A5904_RS10250	COG0285	dihydrofolate synthase activity
A5904_RS10255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A5904_RS10260	COG0159	tryptophan synthase activity
A5904_RS10265	COG0133	tryptophan synthase activity
A5904_RS10270	COG0135	phosphoribosylanthranilate isomerase activity
A5904_RS10275	COG0101	tRNA pseudouridine synthase activity
A5904_RS10285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A5904_RS10300	COG0746	molybdenum cofactor guanylyltransferase activity
A5904_RS10305	COG1763	Mo-molybdopterin cofactor biosynthetic process
A5904_RS10310	COG0303	'Molybdopterin
A5904_RS10315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A5904_RS10355	COG1294	oxidase, subunit
A5904_RS10360	COG1271	oxidase subunit
A5904_RS10375	COG0842	Transport permease protein
A5904_RS10380	COG0842	Transport permease protein
A5904_RS10385	COG1131	(ABC) transporter
A5904_RS10405	COG2814	Major facilitator Superfamily
A5904_RS10410	COG0589	response to stress
A5904_RS10420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A5904_RS10420	COG0047	phosphoribosylformylglycinamidine synthase activity
A5904_RS10425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A5904_RS10430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A5904_RS10440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A5904_RS10450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A5904_RS10455	COG0459	protein refolding
A5904_RS10465	COG2046	Belongs to the sulfate adenylyltransferase family
A5904_RS10465	COG0529	Catalyzes the synthesis of activated sulfate
A5904_RS10475	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A5904_RS10480	COG3258	Cytochrome c
A5904_RS10490	COG1333	cytochrome c biogenesis protein
A5904_RS10500	COG0737	Belongs to the 5'-nucleotidase family
A5904_RS10525	COG1845	cytochrome c oxidase, subunit III
A5904_RS10530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A5904_RS10535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A5904_RS10540	COG1484	DNA-dependent DNA replication
A5904_RS10550	COG1484	DNA-dependent DNA replication
A5904_RS10565	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A5904_RS10570	COG0154	amidase activity
A5904_RS10575	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A5904_RS10610	COG3394	polysaccharide catabolic process
A5904_RS10615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A5904_RS10625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A5904_RS10635	COG1657	PFAM Prenyltransferase squalene oxidase
A5904_RS10640	COG1562	ergosterol biosynthetic process
A5904_RS10645	COG1136	(ABC) transporter
A5904_RS10660	COG1136	(ABC) transporter
A5904_RS10665	COG0577	efflux transmembrane transporter activity
A5904_RS10680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A5904_RS10695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A5904_RS10700	COG1127	ABC transporter
A5904_RS10705	COG1538	Outer membrane efflux protein
A5904_RS10750	COG4115	mRNA cleavage
A5904_RS10755	COG2161	toxin-antitoxin pair type II binding
A5904_RS10770	COG0358	DNA primase activity
A5904_RS10775	COG1193	negative regulation of DNA recombination
A5904_RS10780	COG1610	YqeY-like protein
A5904_RS10785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A5904_RS10795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A5904_RS10800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A5904_RS10810	COG0326	Molecular chaperone. Has ATPase activity
A5904_RS10815	COG2363	Small membrane protein
A5904_RS10830	COG2943	transferase activity, transferring hexosyl groups
A5904_RS10845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A5904_RS10860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A5904_RS10865	COG1271	oxidase subunit
A5904_RS10870	COG1294	oxidase, subunit
A5904_RS10885	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A5904_RS10905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A5904_RS10910	COG0037	tRNA processing
A5904_RS10915	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A5904_RS10915	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A5904_RS10925	COG0736	holo-[acyl-carrier-protein] synthase activity
A5904_RS10930	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A5904_RS10935	COG1381	Involved in DNA repair and RecF pathway recombination
A5904_RS10940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A5904_RS10945	COG0571	ribonuclease III activity
A5904_RS10955	COG0681	Belongs to the peptidase S26 family
A5904_RS10960	COG0481	GTPase activity
A5904_RS10965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A5904_RS10980	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A5904_RS10995	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A5904_RS11000	COG4988	ABC transporter
A5904_RS11025	COG1214	PFAM Peptidase M22, glycoprotease
A5904_RS11030	COG1199	ATP-dependent helicase activity
A5904_RS11040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A5904_RS11045	COG0791	NLP P60 protein
A5904_RS11075	COG0586	Pfam SNARE associated Golgi protein
A5904_RS11090	COG0583	DNA-binding transcription factor activity
A5904_RS11160	COG0095	Lipoate-protein ligase
A5904_RS11170	COG0509	glycine decarboxylation via glycine cleavage system
A5904_RS11180	COG0509	glycine decarboxylation via glycine cleavage system
A5904_RS11185	COG2048	Heterodisulfide reductase, subunit B
A5904_RS11215	COG2210	Belongs to the sulfur carrier protein TusA family
A5904_RS11220	COG0425	Belongs to the sulfur carrier protein TusA family
A5904_RS11225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A5904_RS11230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A5904_RS11235	COG3302	dmso reductase anchor subunit
A5904_RS11240	COG0437	4 iron, 4 sulfur cluster binding
A5904_RS11245	COG0437	4 iron, 4 sulfur cluster binding
A5904_RS11250	COG0243	molybdopterin cofactor binding
A5904_RS11260	COG0315	cyclic pyranopterin monophosphate synthase activity
A5904_RS11270	COG5000	phosphorelay sensor kinase activity
A5904_RS11300	COG3439	Domain of unknown function DUF302
A5904_RS11305	COG0737	Belongs to the 5'-nucleotidase family
A5904_RS11310	COG1077	Cell shape determining protein MreB Mrl
A5904_RS11315	COG1792	Involved in formation and maintenance of cell shape
A5904_RS11325	COG0768	penicillin binding
A5904_RS11330	COG0772	Belongs to the SEDS family
A5904_RS11335	COG1686	Belongs to the peptidase S11 family
A5904_RS11345	COG0321	lipoyl(octanoyl) transferase activity
A5904_RS11350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A5904_RS11400	COG0751	glycine-tRNA ligase activity
A5904_RS11405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A5904_RS11440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A5904_RS11445	COG2154	pterin-4-alpha-carbinolamine dehydratase
A5904_RS11450	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A5904_RS11460	COG3023	N-Acetylmuramoyl-L-alanine amidase
A5904_RS11470	COG0450	alkyl hydroperoxide reductase
A5904_RS11475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A5904_RS11515	COG0247	lactate metabolic process
A5904_RS11520	COG0277	FAD linked oxidase domain protein
A5904_RS11525	COG0277	FAD linked oxidase domain protein
A5904_RS11550	COG1929	Belongs to the glycerate kinase type-1 family
A5904_RS11595	COG0242	peptide deformylase activity
A5904_RS11605	COG0235	Class ii aldolase
A5904_RS11610	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
A5904_RS11620	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A5904_RS11630	COG0564	pseudouridine synthase activity
A5904_RS11645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A5904_RS11645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A5904_RS11660	COG0045	succinate-CoA ligase (ADP-forming) activity
A5904_RS11665	COG0538	isocitrate dehydrogenase activity
A5904_RS11670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A5904_RS11680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A5904_RS11685	COG1388	LysM domain
A5904_RS11685	COG0741	lytic transglycosylase activity
A5904_RS11695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A5904_RS11705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A5904_RS11710	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A5904_RS11720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A5904_RS11725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A5904_RS11730	COG0137	argininosuccinate synthase activity
A5904_RS11745	COG0328	RNA-DNA hybrid ribonuclease activity
A5904_RS11750	COG2226	methyltransferase
A5904_RS11755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A5904_RS11760	COG0612	Peptidase, M16
A5904_RS11765	COG1185	polyribonucleotide nucleotidyltransferase activity
A5904_RS11770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A5904_RS11775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A5904_RS11780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A5904_RS11785	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A5904_RS11790	COG0195	Participates in both transcription termination and antitermination
A5904_RS11795	COG0779	Required for maturation of 30S ribosomal subunits
A5904_RS11880	COG1266	CAAX protease self-immunity
A5904_RS11890	COG1376	ErfK ybiS ycfS ynhG family protein
A5904_RS11890	COG1388	LysM domain
A5904_RS11900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A5904_RS11905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A5904_RS11915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A5904_RS11925	COG0492	ferredoxin-NADP+ reductase activity
A5904_RS11930	COG1193	negative regulation of DNA recombination
A5904_RS11940	COG0585	pseudouridine synthase activity
A5904_RS11945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A5904_RS11950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A5904_RS11955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A5904_RS11960	COG0560	Phosphoserine phosphatase
A5904_RS11965	COG0678	peroxiredoxin activity
A5904_RS11965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A5904_RS11970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A5904_RS11980	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A5904_RS12005	COG2003	Belongs to the UPF0758 family
A5904_RS12010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A5904_RS12015	COG0756	dUTP diphosphatase activity
A5904_RS12025	COG0717	Belongs to the dCTP deaminase family
A5904_RS12030	COG0489	protein tyrosine kinase activity
A5904_RS12040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A5904_RS12045	COG0484	heat shock protein binding
A5904_RS12050	COG0443	Heat shock 70 kDa protein
A5904_RS12055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A5904_RS12060	COG1420	regulation of RNA biosynthetic process
A5904_RS12065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A5904_RS12070	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A5904_RS12075	COG3046	protein related to deoxyribodipyrimidine photolyase
A5904_RS12110	COG1028	Short-chain dehydrogenase reductase Sdr
A5904_RS12160	COG4221	oxidoreductase activity
A5904_RS12170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A5904_RS12180	COG0312	modulator of DNA gyrase
A5904_RS12185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A5904_RS12190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A5904_RS12195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A5904_RS12200	COG0149	triose-phosphate isomerase activity
A5904_RS12205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A5904_RS12215	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS12220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS12225	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS12230	COG0649	NAD binding
A5904_RS12235	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A5904_RS12245	COG1034	ATP synthesis coupled electron transport
A5904_RS12250	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A5904_RS12255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS12265	COG0713	ATP synthesis coupled electron transport
A5904_RS12280	COG1007	ATP synthesis coupled electron transport
A5904_RS12295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A5904_RS12300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A5904_RS12305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A5904_RS12310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A5904_RS12315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A5904_RS12320	COG0072	phenylalanine-tRNA ligase activity
A5904_RS12325	COG0776	regulation of translation
A5904_RS12340	COG1116	anion transmembrane transporter activity
A5904_RS12350	COG0469	pyruvate kinase activity
A5904_RS12350	COG0469	pyruvate kinase activity
A5904_RS12375	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS12380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS12380	COG0649	NAD binding
A5904_RS12380	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS12385	COG0649	NAD binding
A5904_RS12385	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS12385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS12390	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A5904_RS12400	COG1034	ATP synthesis coupled electron transport
A5904_RS12405	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A5904_RS12410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A5904_RS12425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A5904_RS12435	COG1007	ATP synthesis coupled electron transport
A5904_RS12450	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A5904_RS12470	COG0735	belongs to the Fur family
A5904_RS12475	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A5904_RS12485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A5904_RS12505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A5904_RS12525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A5904_RS12535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A5904_RS12540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A5904_RS12590	COG1872	DUF167
A5904_RS12595	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A5904_RS12605	COG1566	PFAM secretion protein HlyD family protein
A5904_RS12615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A5904_RS12640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A5904_RS12640	COG0543	2 iron, 2 sulfur cluster binding
A5904_RS12645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A5904_RS12650	COG0390	transport system, permease component
A5904_RS12655	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A5904_RS12660	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A5904_RS12665	COG0501	Belongs to the peptidase M48B family
A5904_RS12670	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A5904_RS12675	COG2226	methyltransferase
A5904_RS12680	COG0596	Alpha beta hydrolase
A5904_RS12685	COG0156	8-amino-7-oxononanoate synthase activity
A5904_RS12690	COG1040	competence protein
A5904_RS12695	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A5904_RS12705	COG0477	Major facilitator Superfamily
A5904_RS12710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A5904_RS12715	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A5904_RS12720	COG1519	Transferase
A5904_RS12730	COG0859	PFAM glycosyl transferase family 9
A5904_RS12755	COG0438	transferase activity, transferring glycosyl groups
A5904_RS12765	COG0463	Glycosyl transferase, family 2
A5904_RS12770	COG0494	nUDIX hydrolase
A5904_RS12780	COG0653	protein targeting
A5904_RS12790	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A5904_RS12795	COG0625	glutathione transferase activity
A5904_RS12815	COG2001	Belongs to the MraZ family
A5904_RS12820	COG0275	rRNA processing
A5904_RS12835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A5904_RS12840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A5904_RS12845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A5904_RS12850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A5904_RS12855	COG0772	Belongs to the SEDS family
A5904_RS12860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A5904_RS12865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A5904_RS12870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A5904_RS12875	COG1181	Belongs to the D-alanine--D-alanine ligase family
A5904_RS12880	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A5904_RS12895	COG0058	SHG alpha-glucan phosphorylase activity
A5904_RS12900	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A5904_RS12910	COG0793	Belongs to the peptidase S41A family
A5904_RS12915	COG0693	protein deglycase activity
A5904_RS12920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A5904_RS12925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A5904_RS12930	COG0542	response to heat
A5904_RS12935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A5904_RS12940	COG2813	Specifically methylates the guanine in position
A5904_RS12940	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A5904_RS12945	COG0625	glutathione transferase activity
A5904_RS12955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A5904_RS12990	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A5904_RS13000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A5904_RS13005	COG0768	penicillin binding
A5904_RS13015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A5904_RS13025	COG0823	Involved in the tonB-independent uptake of proteins
A5904_RS13035	COG0583	DNA-binding transcription factor activity
A5904_RS13045	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A5904_RS13050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A5904_RS13055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A5904_RS13060	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A5904_RS13065	COG3047	cAMP biosynthetic process
A5904_RS13065	COG2885	chlorophyll binding
A5904_RS13070	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A5904_RS13075	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A5904_RS13085	COG0165	Argininosuccinate lyase
A5904_RS13100	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A5904_RS13110	COG1611	Belongs to the LOG family
A5904_RS13115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A5904_RS13115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A5904_RS13120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A5904_RS13125	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A5904_RS13130	COG1333	cytochrome c biogenesis protein
A5904_RS13135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A5904_RS13145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A5904_RS13150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A5904_RS13155	COG3386	PFAM SMP-30 Gluconolaconase
A5904_RS13165	COG2814	Major facilitator Superfamily
A5904_RS13175	COG0488	(ABC) transporter
A5904_RS13275	COG3179	chitinase
A5904_RS13305	COG4964	Belongs to the GSP D family
A5904_RS13375	COG0792	nuclease activity
A5904_RS13380	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A5904_RS13385	COG0277	FAD linked oxidase domain protein
A5904_RS13410	COG0583	DNA-binding transcription factor activity
A5904_RS13435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A5904_RS13445	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A5904_RS13450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A5904_RS13460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A5904_RS13465	COG2833	Protein of unknown function (DUF455)
A5904_RS13520	COG0386	Belongs to the glutathione peroxidase family
A5904_RS13555	COG2095	MarC family integral membrane protein
A5904_RS13565	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A5904_RS13570	COG1051	belongs to the nudix hydrolase family
A5904_RS13575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A5904_RS13585	COG0217	transcriptional regulatory protein
A5904_RS13590	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A5904_RS13595	COG0632	four-way junction helicase activity
A5904_RS13600	COG2255	four-way junction helicase activity
A5904_RS13605	COG0824	Thioesterase
A5904_RS13625	COG0823	Involved in the tonB-independent uptake of proteins
A5904_RS13630	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A5904_RS13635	COG0602	queuosine metabolic process
A5904_RS13650	COG0181	hydroxymethylbilane synthase activity
A5904_RS13660	COG0113	porphobilinogen synthase activity
A5904_RS13675	COG0477	Major facilitator Superfamily
A5904_RS13680	COG1272	protein, Hemolysin III
A5904_RS13710	COG0424	maF-like protein
A5904_RS13725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A5904_RS13735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A5904_RS13750	COG1560	Kdo2-lipid A biosynthetic process
A5904_RS13760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A5904_RS13765	COG0706	membrane insertase activity
A5904_RS13770	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A5904_RS13775	COG0594	ribonuclease P activity
A5904_RS13780	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A5904_RS13785	COG1127	ABC transporter
A5904_RS13790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A5904_RS13795	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A5904_RS13810	COG1131	(ABC) transporter
A5904_RS13815	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A5904_RS13820	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A5904_RS13830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A5904_RS13845	COG0018	arginyl-trna synthetase
A5904_RS13850	COG1196	nuclear chromosome segregation
A5904_RS13850	COG3264	Mechanosensitive ion channel
A5904_RS13855	COG0477	Major facilitator Superfamily
A5904_RS13860	COG0583	DNA-binding transcription factor activity
A5904_RS13870	COG0708	Exodeoxyribonuclease III
A5904_RS13880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A5904_RS13885	COG0625	glutathione transferase activity
A5904_RS13895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A5904_RS13900	COG1047	Peptidyl-prolyl cis-trans
A5904_RS13905	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A5904_RS13910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A5904_RS13930	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A5904_RS13935	COG0237	dephospho-CoA kinase activity
A5904_RS13940	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A5904_RS13945	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A5904_RS13960	COG0739	heme binding
A5904_RS13960	COG0741	lytic transglycosylase activity
A5904_RS13960	COG1196	nuclear chromosome segregation
A5904_RS13965	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A5904_RS13975	COG2264	protein methyltransferase activity
A5904_RS13980	COG0439	Biotin carboxylase
A5904_RS13985	COG0511	ligase activity, forming carbon-carbon bonds
A5904_RS13990	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A5904_RS13995	COG0778	Nitroreductase
A5904_RS14010	COG1555	photosystem II stabilization
A5904_RS14015	COG0537	adenosine 5'-monophosphoramidase activity
A5904_RS14020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A5904_RS14025	COG0352	thiamine-phosphate diphosphorylase activity
A5904_RS14030	COG0351	phosphomethylpyrimidine kinase
A5904_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
A5904_RS14050	COG0811	peptide transport
A5904_RS14075	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A5904_RS14250	COG0583	DNA-binding transcription factor activity
A5904_RS14275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A5904_RS14315	COG0776	regulation of translation
A5904_RS14325	COG3668	Plasmid stabilization system
A5904_RS14385	COG0210	DNA helicase
A5904_RS14450	COG1484	DNA-dependent DNA replication
A5904_RS14455	COG4584	PFAM Integrase catalytic
A5904_RS14495	COG0741	lytic transglycosylase activity
A5904_RS14500	COG5632	N-Acetylmuramoyl-L-alanine amidase
A5904_RS14500	COG3409	Peptidoglycan-binding domain 1 protein
A5904_RS14545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A5904_RS14560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A5904_RS14600	COG0187	DNA topoisomerase II activity
A5904_RS14620	COG0629	single-stranded DNA binding
A5904_RS14690	COG4974	Belongs to the 'phage' integrase family
A5904_RS14730	COG0811	peptide transport
A5904_RS14745	COG1484	DNA-dependent DNA replication
A5904_RS14760	COG1205	dead DEAH box helicase
A5904_RS14760	COG1111	helicase
A5904_RS14765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A5904_RS14880	COG3344	reverse transcriptase
A5904_RS14930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A5904_RS14935	COG1215	transferase activity, transferring glycosyl groups
A5904_RS15050	COG0542	response to heat
A5904_RS15105	COG1192	Involved in chromosome partitioning
A5904_RS15110	COG1475	DNA binding
A5904_RS15120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A5904_RS15410	COG2188	Transcriptional regulator
A5904_RS15415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A5904_RS15440	COG1192	Involved in chromosome partitioning