locus-tag	class	description
ATC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ATC_RS00010	COG0592	DNA-directed DNA polymerase activity
ATC_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ATC_RS00020	COG0187	DNA topoisomerase II activity
ATC_RS00025	COG0493	'glutamate synthase
ATC_RS00025	COG0543	2 iron, 2 sulfur cluster binding
ATC_RS00030	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ATC_RS00040	COG0850	regulation of cytokinetic process
ATC_RS00045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ATC_RS00050	COG1754	DNA topoisomerase type I activity
ATC_RS00050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ATC_RS00055	COG2922	Belongs to the Smg family
ATC_RS00060	COG0758	DNA mediated transformation
ATC_RS00070	COG0242	peptide deformylase activity
ATC_RS00075	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ATC_RS00080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ATC_RS00080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ATC_RS00085	COG5000	phosphorelay sensor kinase activity
ATC_RS00090	COG2204	response regulator
ATC_RS00095	COG0521	Mo-molybdopterin cofactor biosynthetic process
ATC_RS00105	COG0445	tRNA wobble uridine modification
ATC_RS00110	COG0357	Ribosomal RNA small subunit methyltransferase G
ATC_RS00120	COG1475	DNA binding
ATC_RS00130	COG0356	it plays a direct role in the translocation of protons across the membrane
ATC_RS00140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ATC_RS00145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ATC_RS00150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ATC_RS00155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ATC_RS00170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ATC_RS00180	COG1484	DNA-dependent DNA replication
ATC_RS00185	COG4584	PFAM Integrase catalytic
ATC_RS00270	COG0210	DNA helicase
ATC_RS00300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ATC_RS00315	COG1970	mechanosensitive ion channel activity
ATC_RS00320	COG1322	Protein conserved in bacteria
ATC_RS00325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ATC_RS00335	COG0483	inositol monophosphate 1-phosphatase activity
ATC_RS00340	COG1494	fructose-1,6-bisphosphatase
ATC_RS00345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ATC_RS00350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ATC_RS00355	COG0126	phosphoglycerate kinase activity
ATC_RS00360	COG0469	pyruvate kinase activity
ATC_RS00370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ATC_RS00375	COG0546	phosphoglycolate phosphatase activity
ATC_RS00385	COG0512	Glutamine amidotransferase of anthranilate synthase
ATC_RS00390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ATC_RS00395	COG0134	indole-3-glycerol-phosphate synthase activity
ATC_RS00410	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ATC_RS00420	COG2945	thiolester hydrolase activity
ATC_RS00425	COG1131	(ABC) transporter
ATC_RS00450	COG4942	peptidase
ATC_RS00475	COG3668	Plasmid stabilization system
ATC_RS00485	COG1475	DNA binding
ATC_RS00490	COG1192	Involved in chromosome partitioning
ATC_RS00530	COG3039	Transposase
ATC_RS00610	COG0463	Glycosyl transferase, family 2
ATC_RS00635	COG3039	Transposase
ATC_RS00665	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ATC_RS00675	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ATC_RS00690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ATC_RS00705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ATC_RS00710	COG3039	Transposase
ATC_RS00715	COG0745	RESPONSE REGULATOR receiver
ATC_RS00720	COG1937	Protein conserved in bacteria
ATC_RS00735	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ATC_RS00780	COG3701	Conjugal transfer protein
ATC_RS00815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ATC_RS00860	COG3039	Transposase
ATC_RS00875	COG0629	single-stranded DNA binding
ATC_RS00895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ATC_RS00900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ATC_RS00920	COG0109	protoheme IX farnesyltransferase activity
ATC_RS00945	COG0745	RESPONSE REGULATOR receiver
ATC_RS00955	COG0643	Histidine kinase
ATC_RS00955	COG0784	Response regulator, receiver
ATC_RS00955	COG2198	Histidine kinase
ATC_RS00970	COG0840	transmembrane signaling receptor activity
ATC_RS00975	COG0784	Response regulator, receiver
ATC_RS00975	COG0835	chemotaxis
ATC_RS00985	COG2200	EAL domain
ATC_RS01000	COG1484	DNA-dependent DNA replication
ATC_RS01025	COG0438	transferase activity, transferring glycosyl groups
ATC_RS01055	COG3436	PFAM IS66 Orf2 family protein
ATC_RS01060	COG2433	Pfam Transposase IS66
ATC_RS01090	COG1215	transferase activity, transferring glycosyl groups
ATC_RS01120	COG1461	Dihydroxyacetone kinase
ATC_RS01125	COG2376	Dihydroxyacetone kinase
ATC_RS01150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ATC_RS01165	COG0359	binds to the 23S rRNA
ATC_RS01180	COG0360	Binds together with S18 to 16S ribosomal RNA
ATC_RS01185	COG1472	Belongs to the glycosyl hydrolase 3 family
ATC_RS01190	COG0531	amino acid
ATC_RS01200	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ATC_RS01225	COG0363	glucosamine-6-phosphate deaminase activity
ATC_RS01240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ATC_RS01255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ATC_RS01260	COG1074	ATP-dependent DNA helicase activity
ATC_RS01265	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ATC_RS01275	COG3220	belongs to the UPF0276 family
ATC_RS01290	COG2204	response regulator
ATC_RS01300	COG2205	protein histidine kinase activity
ATC_RS01305	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ATC_RS01310	COG0540	Belongs to the ATCase OTCase family
ATC_RS01315	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ATC_RS01325	COG1678	Uncharacterized ACR, COG1678
ATC_RS01330	COG0189	ligase activity
ATC_RS01345	COG0316	Belongs to the HesB IscA family
ATC_RS01365	COG3431	PFAM Phosphate-starvation-inducible E
ATC_RS01375	COG0022	dehydrogenase e1 component
ATC_RS01375	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC_RS01380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ATC_RS01390	COG3273	potassium ion transport
ATC_RS01390	COG0471	metal ion transport
ATC_RS01395	COG0745	RESPONSE REGULATOR receiver
ATC_RS01400	COG2205	protein histidine kinase activity
ATC_RS01410	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ATC_RS01420	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ATC_RS01430	COG0415	Belongs to the DNA photolyase family
ATC_RS01440	COG2814	Major facilitator Superfamily
ATC_RS01475	COG2226	methyltransferase
ATC_RS01480	COG2967	ApaG domain
ATC_RS01485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ATC_RS01505	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ATC_RS01510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ATC_RS01525	COG0436	Aminotransferase
ATC_RS01535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ATC_RS01545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ATC_RS01555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ATC_RS01560	COG4591	ABC-type transport system involved in lipoprotein release permease component
ATC_RS01565	COG1136	(ABC) transporter
ATC_RS01575	COG0658	competence protein
ATC_RS01575	COG2333	competence protein COMEC
ATC_RS01585	COG0848	biopolymer transport protein
ATC_RS01600	COG1663	tetraacyldisaccharide 4'-kinase activity
ATC_RS01605	COG2835	tetraacyldisaccharide 4'-kinase activity
ATC_RS01610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ATC_RS01630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ATC_RS01640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ATC_RS01645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ATC_RS01660	COG0330	HflC and HflK could
ATC_RS01670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ATC_RS01680	COG2814	Major facilitator Superfamily
ATC_RS01705	COG0805	protein transport
ATC_RS01710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ATC_RS01715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ATC_RS01720	COG0140	phosphoribosyl-ATP diphosphatase activity
ATC_RS01720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ATC_RS01725	COG0107	imidazoleglycerol-phosphate synthase activity
ATC_RS01730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ATC_RS01735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ATC_RS01740	COG0131	Imidazoleglycerol-phosphate dehydratase
ATC_RS01745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ATC_RS01755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ATC_RS01760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ATC_RS01765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ATC_RS01775	COG0842	Transport permease protein
ATC_RS01780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ATC_RS01815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ATC_RS01825	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ATC_RS01845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ATC_RS01845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ATC_RS01845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ATC_RS01850	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ATC_RS01855	COG1660	Displays ATPase and GTPase activities
ATC_RS01870	COG1376	ErfK ybiS ycfS ynhG family protein
ATC_RS01880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ATC_RS01890	COG0297	glycogen (starch) synthase activity
ATC_RS01925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ATC_RS01930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ATC_RS01940	COG2204	response regulator
ATC_RS01960	COG0497	DNA recombination
ATC_RS01965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ATC_RS01970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ATC_RS01975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ATC_RS01990	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ATC_RS02020	COG0114	fumarate hydratase activity
ATC_RS02025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ATC_RS02035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ATC_RS02035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ATC_RS02040	COG0006	proline dipeptidase activity
ATC_RS02060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ATC_RS02075	COG0495	leucyl-tRNA aminoacylation
ATC_RS02080	COG1534	Rna-binding protein
ATC_RS02085	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ATC_RS02115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ATC_RS02180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ATC_RS02185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ATC_RS02190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ATC_RS02200	COG1294	oxidase, subunit
ATC_RS02205	COG1271	oxidase subunit
ATC_RS02210	COG0166	Belongs to the GPI family
ATC_RS02215	COG1686	Belongs to the peptidase S11 family
ATC_RS02245	COG0642	Histidine kinase
ATC_RS02260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ATC_RS02270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ATC_RS02285	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ATC_RS02290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ATC_RS02295	COG2890	protein-(glutamine-N5) methyltransferase activity
ATC_RS02300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ATC_RS02305	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ATC_RS02310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ATC_RS02320	COG0116	Belongs to the methyltransferase superfamily
ATC_RS02320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ATC_RS02325	COG0552	protein localization to endoplasmic reticulum
ATC_RS02330	COG2884	Cell division ATP-binding protein ftsE
ATC_RS02335	COG2177	Part of the ABC transporter FtsEX involved in
ATC_RS02350	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ATC_RS02350	COG3264	Mechanosensitive ion channel
ATC_RS02355	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ATC_RS02365	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ATC_RS02375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ATC_RS02385	COG4221	oxidoreductase activity
ATC_RS02410	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ATC_RS02440	COG1215	transferase activity, transferring glycosyl groups
ATC_RS02460	COG0513	Belongs to the DEAD box helicase family
ATC_RS02465	COG1278	Cold shock
ATC_RS02540	COG1215	transferase activity, transferring glycosyl groups
ATC_RS02555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ATC_RS02560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ATC_RS02570	COG1230	cation diffusion facilitator family transporter
ATC_RS02575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ATC_RS02580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ATC_RS02590	COG1449	Belongs to the glycosyl hydrolase 57 family
ATC_RS02595	COG1940	carbohydrate kinase activity
ATC_RS02610	COG2733	membrane
ATC_RS02620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ATC_RS02625	COG1702	phosphate starvation-inducible protein PhoH
ATC_RS02630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ATC_RS02635	COG4535	Mg2 and Co2 transporter CorC
ATC_RS02640	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ATC_RS02650	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ATC_RS02665	COG3220	belongs to the UPF0276 family
ATC_RS02685	COG4232	protein-disulfide reductase activity
ATC_RS02700	COG2814	Major facilitator Superfamily
ATC_RS02710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATC_RS02710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ATC_RS02725	COG2226	methyltransferase
ATC_RS02780	COG0033	Phosphoglucomutase
ATC_RS02795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ATC_RS02800	COG0228	four-way junction DNA binding
ATC_RS02805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ATC_RS02810	COG0336	Belongs to the RNA methyltransferase TrmD family
ATC_RS02815	COG0335	large ribosomal subunit rRNA binding
ATC_RS02835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ATC_RS02840	COG3118	belongs to the thioredoxin family
ATC_RS02855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ATC_RS02860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ATC_RS02865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ATC_RS02865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ATC_RS02880	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ATC_RS02885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ATC_RS02900	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ATC_RS02925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ATC_RS02935	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ATC_RS02945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ATC_RS02950	COG0081	regulation of translation
ATC_RS02955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ATC_RS02960	COG0222	ribosome binding
ATC_RS02965	COG0085	RNA polymerase activity
ATC_RS02970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ATC_RS02975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ATC_RS02980	COG0049	tRNA binding
ATC_RS02985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ATC_RS02990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ATC_RS02995	COG0051	transcription antitermination factor activity, RNA binding
ATC_RS03000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ATC_RS03005	COG0088	Forms part of the polypeptide exit tunnel
ATC_RS03010	COG0089	rRNA binding
ATC_RS03015	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ATC_RS03020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ATC_RS03025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ATC_RS03035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ATC_RS03040	COG0255	Belongs to the universal ribosomal protein uL29 family
ATC_RS03045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ATC_RS03050	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ATC_RS03055	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ATC_RS03060	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ATC_RS03065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ATC_RS03070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ATC_RS03075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ATC_RS03080	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ATC_RS03085	COG1841	ribosomal large subunit assembly
ATC_RS03090	COG0200	Binds to the 23S rRNA
ATC_RS03095	COG0201	protein transport
ATC_RS03100	COG0563	adenylate kinase activity
ATC_RS03105	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ATC_RS03110	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ATC_RS03115	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ATC_RS03120	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ATC_RS03125	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ATC_RS03130	COG0202	RNA polymerase activity
ATC_RS03135	COG0203	ribosomal protein L17
ATC_RS03145	COG0629	single-stranded DNA binding
ATC_RS03160	COG0312	modulator of DNA gyrase
ATC_RS03165	COG0617	tRNA 3'-terminal CCA addition
ATC_RS03170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ATC_RS03175	COG0066	3-isopropylmalate dehydratase activity
ATC_RS03185	COG0259	pyridoxamine-phosphate oxidase activity
ATC_RS03190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ATC_RS03200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ATC_RS03205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ATC_RS03210	COG1845	cytochrome c oxidase, subunit III
ATC_RS03225	COG0109	protoheme IX farnesyltransferase activity
ATC_RS03230	COG2814	Major facilitator Superfamily
ATC_RS03235	COG1968	undecaprenyl-diphosphatase activity
ATC_RS03240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ATC_RS03250	COG0505	Belongs to the CarA family
ATC_RS03270	COG0531	amino acid
ATC_RS03275	COG0142	geranyltranstransferase activity
ATC_RS03300	COG0488	(ABC) transporter
ATC_RS03310	COG1573	uracil-dna glycosylase
ATC_RS03315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ATC_RS03320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ATC_RS03330	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ATC_RS03360	COG0811	peptide transport
ATC_RS03395	COG0768	penicillin binding
ATC_RS03410	COG0167	dihydroorotate dehydrogenase activity
ATC_RS03415	COG0408	coproporphyrinogen oxidase activity
ATC_RS03420	COG0009	L-threonylcarbamoyladenylate synthase
ATC_RS03425	COG0151	Belongs to the GarS family
ATC_RS03430	COG0138	bifunctional purine biosynthesis protein purh
ATC_RS03435	COG1979	alcohol dehydrogenase
ATC_RS03440	COG0012	GTP binding
ATC_RS03445	COG0193	aminoacyl-tRNA hydrolase activity
ATC_RS03450	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ATC_RS03455	COG0768	penicillin binding
ATC_RS03470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ATC_RS03475	COG1692	metallophosphoesterase
ATC_RS03490	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ATC_RS03525	COG0589	response to stress
ATC_RS03530	COG0442	prolyl-tRNA aminoacylation
ATC_RS03555	COG1271	oxidase subunit
ATC_RS03565	COG0531	amino acid
ATC_RS03575	COG0525	valine-tRNA ligase activity
ATC_RS03590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ATC_RS03605	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ATC_RS03625	COG1965	Belongs to the frataxin family
ATC_RS03630	COG0514	ATP-dependent DNA helicase (RecQ)
ATC_RS03640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ATC_RS03650	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ATC_RS03655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ATC_RS03660	COG3852	Histidine kinase
ATC_RS03665	COG2204	response regulator
ATC_RS03770	COG0822	iron-sulfur transferase activity
ATC_RS03870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ATC_RS03885	COG1216	Glycosyl transferase, family 2
ATC_RS03885	COG0438	transferase activity, transferring glycosyl groups
ATC_RS03910	COG3604	Transcriptional regulator
ATC_RS03980	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ATC_RS03985	COG0268	Binds directly to 16S ribosomal RNA
ATC_RS04000	COG2957	Belongs to the agmatine deiminase family
ATC_RS04005	COG1187	pseudouridine synthase activity
ATC_RS04015	COG0494	nUDIX hydrolase
ATC_RS04040	COG0254	rRNA binding
ATC_RS04045	COG0281	malic enzyme
ATC_RS04050	COG0129	dihydroxy-acid dehydratase activity
ATC_RS04060	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ATC_RS04060	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ATC_RS04070	COG2350	Protein conserved in bacteria
ATC_RS04075	COG2917	probably involved in intracellular septation
ATC_RS04090	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ATC_RS04100	COG1959	2 iron, 2 sulfur cluster binding
ATC_RS04105	COG1104	cysteine desulfurase activity
ATC_RS04110	COG0822	iron-sulfur transferase activity
ATC_RS04115	COG0316	Belongs to the HesB IscA family
ATC_RS04120	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ATC_RS04125	COG0443	Heat shock 70 kDa protein
ATC_RS04140	COG0482	sulfurtransferase activity
ATC_RS04155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ATC_RS04160	COG0704	Plays a role in the regulation of phosphate uptake
ATC_RS04165	COG0248	Ppx GppA phosphatase
ATC_RS04175	COG0052	Belongs to the universal ribosomal protein uS2 family
ATC_RS04180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ATC_RS04185	COG0528	UMP kinase activity
ATC_RS04195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ATC_RS04200	COG0575	Belongs to the CDS family
ATC_RS04205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ATC_RS04225	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ATC_RS04230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ATC_RS04235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ATC_RS04250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ATC_RS04255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ATC_RS04265	COG0825	malonyl-CoA metabolic process
ATC_RS04270	COG0037	tRNA processing
ATC_RS04315	COG1132	(ABC) transporter
ATC_RS04335	COG1592	Rubrerythrin
ATC_RS04350	COG1570	exodeoxyribonuclease VII activity
ATC_RS04355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ATC_RS04380	COG0741	lytic transglycosylase activity
ATC_RS04390	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ATC_RS04400	COG1121	(ABC) transporter
ATC_RS04405	COG2223	nitrite transmembrane transporter activity
ATC_RS04410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ATC_RS04475	COG3039	Transposase
ATC_RS04485	COG0616	signal peptide processing
ATC_RS04490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ATC_RS04495	COG0314	molybdopterin synthase activity
ATC_RS04500	COG1666	GTP binding
ATC_RS04515	COG0509	glycine decarboxylation via glycine cleavage system
ATC_RS04520	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ATC_RS04530	COG0714	Associated with various cellular activities
ATC_RS04545	COG1132	(ABC) transporter
ATC_RS04550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ATC_RS04560	COG0450	alkyl hydroperoxide reductase
ATC_RS04570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ATC_RS04585	COG1850	ribulose-bisphosphate carboxylase activity
ATC_RS04590	COG4451	ribulose bisphosphate carboxylase, small
ATC_RS04615	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ATC_RS04620	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ATC_RS04650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ATC_RS04680	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
ATC_RS04695	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ATC_RS04695	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ATC_RS04695	COG0506	proline dehydrogenase activity
ATC_RS04710	COG0640	Transcriptional regulator
ATC_RS04715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ATC_RS04720	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ATC_RS04730	COG0436	Aminotransferase
ATC_RS04765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ATC_RS04780	COG2814	Major facilitator Superfamily
ATC_RS04785	COG1686	Belongs to the peptidase S11 family
ATC_RS04810	COG0418	dihydroorotase activity
ATC_RS04825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ATC_RS04850	COG0697	spore germination
ATC_RS04855	COG1902	pentaerythritol trinitrate reductase activity
ATC_RS04955	COG0557	exoribonuclease II activity
ATC_RS04980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ATC_RS04985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ATC_RS05000	COG1295	ribonuclease BN
ATC_RS05010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ATC_RS05015	COG0416	fatty acid biosynthetic process
ATC_RS05020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ATC_RS05025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ATC_RS05035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ATC_RS05040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ATC_RS05050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ATC_RS05055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ATC_RS05060	COG0470	DNA polymerase III
ATC_RS05155	COG0583	DNA-binding transcription factor activity
ATC_RS05160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ATC_RS05165	COG3002	Belongs to the UPF0753 family
ATC_RS05180	COG0129	dihydroxy-acid dehydratase activity
ATC_RS05225	COG2078	PFAM AMMECR1 domain protein
ATC_RS05225	COG3885	ferrous iron binding
ATC_RS05230	COG1355	regulation of microtubule-based process
ATC_RS05285	COG2433	Pfam Transposase IS66
ATC_RS05290	COG3436	PFAM IS66 Orf2 family protein
ATC_RS05300	COG1484	DNA-dependent DNA replication
ATC_RS05315	COG4232	protein-disulfide reductase activity
ATC_RS05330	COG1595	DNA-templated transcription, initiation
ATC_RS05340	COG3220	belongs to the UPF0276 family
ATC_RS05365	COG0842	Transport permease protein
ATC_RS05370	COG0842	Transport permease protein
ATC_RS05375	COG1131	(ABC) transporter
ATC_RS05385	COG1538	Outer membrane efflux protein
ATC_RS05390	COG0789	Transcriptional regulator
ATC_RS05415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ATC_RS05420	COG3002	Belongs to the UPF0753 family
ATC_RS05425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ATC_RS05430	COG0583	DNA-binding transcription factor activity
ATC_RS05435	COG3706	GGDEF domain
ATC_RS05440	COG2353	YceI-like domain
ATC_RS05445	COG0655	NAD(P)H dehydrogenase (quinone) activity
ATC_RS05450	COG1733	regulation of RNA biosynthetic process
ATC_RS05560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ATC_RS05580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ATC_RS05585	COG3707	response regulator
ATC_RS05590	COG1648	precorrin-2 dehydrogenase activity
ATC_RS05590	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ATC_RS05595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ATC_RS05600	COG0243	molybdopterin cofactor binding
ATC_RS05605	COG2146	nitrite reductase [NAD(P)H] activity
ATC_RS05610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ATC_RS05620	COG2223	nitrite transmembrane transporter activity
ATC_RS05625	COG1116	anion transmembrane transporter activity
ATC_RS05625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ATC_RS05635	COG3039	Transposase
ATC_RS05685	COG1484	DNA-dependent DNA replication
ATC_RS05740	COG0629	single-stranded DNA binding
ATC_RS05820	COG4962	Type ii secretion system protein e
ATC_RS05850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ATC_RS05895	COG3451	type IV secretory pathway VirB4
ATC_RS05905	COG1598	PFAM Uncharacterised protein family UPF0150
ATC_RS06000	COG3701	Conjugal transfer protein
ATC_RS06005	COG3504	Conjugal transfer protein
ATC_RS06010	COG2948	multi-organism process
ATC_RS06020	COG1192	Involved in chromosome partitioning
ATC_RS06025	COG1475	DNA binding
ATC_RS06040	COG3561	AntA/AntB antirepressor
ATC_RS06110	COG1199	ATP-dependent helicase activity
ATC_RS06135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ATC_RS06135	COG2755	lipolytic protein G-D-S-L family
ATC_RS06255	COG3093	addiction module antidote protein HigA
ATC_RS06275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ATC_RS06340	COG0741	lytic transglycosylase activity
ATC_RS06470	COG0582	viral genome integration into host DNA
ATC_RS06510	COG0729	surface antigen
ATC_RS06520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ATC_RS06525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ATC_RS06530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ATC_RS06535	COG0004	ammonium transporteR
ATC_RS06540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ATC_RS06540	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ATC_RS06545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ATC_RS06550	COG2239	Acts as a magnesium transporter
ATC_RS06555	COG0802	atpase or kinase
ATC_RS06565	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ATC_RS06585	COG0393	Putative heavy-metal-binding
ATC_RS06600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ATC_RS06610	COG0429	hydrolase of the alpha beta-hydrolase fold
ATC_RS06620	COG2373	Large extracellular alpha-helical protein
ATC_RS06625	COG4953	penicillin-binding protein 1C
ATC_RS06630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ATC_RS06635	COG0508	dehydrogenase complex catalyzes the overall conversion of
ATC_RS06640	COG0022	dehydrogenase e1 component
ATC_RS06645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ATC_RS06655	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ATC_RS06660	COG0574	Belongs to the PEP-utilizing enzyme family
ATC_RS06660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ATC_RS06675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ATC_RS06680	COG2171	N-acyltransferase activity
ATC_RS06685	COG0436	Aminotransferase
ATC_RS06695	COG0546	phosphoglycolate phosphatase activity
ATC_RS06705	COG0402	S-adenosylhomocysteine deaminase activity
ATC_RS06715	COG0791	NLP P60 protein
ATC_RS06715	COG1388	LysM domain
ATC_RS06755	COG2271	Major facilitator Superfamily
ATC_RS06760	COG0438	transferase activity, transferring glycosyl groups
ATC_RS06770	COG0745	RESPONSE REGULATOR receiver
ATC_RS06775	COG0811	peptide transport
ATC_RS06805	COG3842	ATPase activity
ATC_RS06825	COG1566	PFAM secretion protein HlyD family protein
ATC_RS06835	COG2132	Multicopper oxidase
ATC_RS06840	COG0105	UTP biosynthetic process
ATC_RS06845	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ATC_RS06860	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ATC_RS06865	COG0124	histidyl-tRNA synthetase
ATC_RS06875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ATC_RS06880	COG1160	GTP binding
ATC_RS06930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ATC_RS06935	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ATC_RS06950	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ATC_RS06960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ATC_RS06965	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ATC_RS06970	COG0287	Prephenate dehydrogenase
ATC_RS06975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ATC_RS06980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ATC_RS06990	COG0776	regulation of translation
ATC_RS06995	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ATC_RS07005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ATC_RS07010	COG0544	peptidyl-prolyl cis-trans isomerase activity
ATC_RS07015	COG0740	serine-type endopeptidase activity
ATC_RS07020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ATC_RS07025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ATC_RS07045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ATC_RS07070	COG5002	protein histidine kinase activity
ATC_RS07070	COG5001	Diguanylate cyclase
ATC_RS07070	COG3447	MASE1 domain protein
ATC_RS07150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ATC_RS07155	COG0215	cysteine-tRNA ligase activity
ATC_RS07160	COG1530	ribonuclease E activity
ATC_RS07170	COG0546	phosphoglycolate phosphatase activity
ATC_RS07180	COG3842	ATPase activity
ATC_RS07190	COG0446	pyridine nucleotide-disulphide oxidoreductase
ATC_RS07205	COG1028	Short-chain dehydrogenase reductase Sdr
ATC_RS07210	COG0616	signal peptide processing
ATC_RS07215	COG0667	Aldo Keto reductase
ATC_RS07230	COG0840	transmembrane signaling receptor activity
ATC_RS07235	COG0835	chemotaxis
ATC_RS07235	COG0784	Response regulator, receiver
ATC_RS07250	COG0784	Response regulator, receiver
ATC_RS07250	COG2198	Histidine kinase
ATC_RS07250	COG0643	Histidine kinase
ATC_RS07280	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ATC_RS07305	COG1815	bacterial-type flagellum-dependent cell motility
ATC_RS07310	COG1558	bacterial-type flagellum-dependent cell motility
ATC_RS07335	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ATC_RS07340	COG1706	bacterial-type flagellum-dependent cell motility
ATC_RS07345	COG3951	Flagellar rod assembly protein muramidase FlgJ
ATC_RS07345	COG1705	Flagellar rod assembly protein muramidase FlgJ
ATC_RS07355	COG1256	bacterial-type flagellum assembly
ATC_RS07375	COG0438	transferase activity, transferring glycosyl groups
ATC_RS07375	COG1216	Glycosyl transferase, family 2
ATC_RS07410	COG3852	Histidine kinase
ATC_RS07420	COG1677	Flagellar hook-basal body complex protein FliE
ATC_RS07430	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ATC_RS07470	COG1338	Plays a role in the flagellum-specific transport system
ATC_RS07475	COG1987	bacterial-type flagellum assembly
ATC_RS07490	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ATC_RS07505	COG1191	sigma factor activity
ATC_RS07510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ATC_RS07515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ATC_RS07520	COG0670	Belongs to the BI1 family
ATC_RS07540	COG0277	FAD linked oxidase domain protein
ATC_RS07545	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ATC_RS07550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ATC_RS07555	COG1428	Deoxynucleoside kinase
ATC_RS07565	COG0617	tRNA 3'-terminal CCA addition
ATC_RS07575	COG0519	Catalyzes the synthesis of GMP from XMP
ATC_RS07585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ATC_RS07585	COG1017	nitric oxide dioxygenase activity
ATC_RS07605	COG3189	MarR family transcriptional regulator
ATC_RS07610	COG0477	Major facilitator Superfamily
ATC_RS07630	COG2814	Major facilitator Superfamily
ATC_RS07645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ATC_RS07670	COG1105	Belongs to the carbohydrate kinase PfkB family
ATC_RS07675	COG0280	phosphate acetyltransferase
ATC_RS07710	COG1914	H( )-stimulated, divalent metal cation uptake system
ATC_RS07715	COG1285	pathogenesis
ATC_RS07725	COG3657	addiction module killer protein
ATC_RS07730	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ATC_RS07760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ATC_RS07775	COG3447	MASE1 domain protein
ATC_RS07775	COG5001	Diguanylate cyclase
ATC_RS07775	COG5002	protein histidine kinase activity
ATC_RS07805	COG1484	DNA-dependent DNA replication
ATC_RS07820	COG3039	Transposase
ATC_RS07845	COG3436	PFAM IS66 Orf2 family protein
ATC_RS07850	COG2433	Pfam Transposase IS66
ATC_RS07885	COG1294	oxidase, subunit
ATC_RS07890	COG1271	oxidase subunit
ATC_RS07895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ATC_RS07900	COG0477	Major facilitator Superfamily
ATC_RS07910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ATC_RS07915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ATC_RS07945	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ATC_RS07970	COG3039	Transposase
ATC_RS07985	COG1271	oxidase subunit
ATC_RS07990	COG1294	oxidase, subunit
ATC_RS08000	COG0243	molybdopterin cofactor binding
ATC_RS08005	COG0437	4 iron, 4 sulfur cluster binding
ATC_RS08010	COG3302	dmso reductase anchor subunit
ATC_RS08040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ATC_RS08060	COG3436	PFAM IS66 Orf2 family protein
ATC_RS08065	COG2433	Pfam Transposase IS66
ATC_RS08075	COG0583	DNA-binding transcription factor activity
ATC_RS08115	COG2433	Pfam Transposase IS66
ATC_RS08120	COG3436	PFAM IS66 Orf2 family protein
ATC_RS08130	COG1113	amino acid transport
ATC_RS08140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ATC_RS08165	COG2814	Major facilitator Superfamily
ATC_RS08170	COG4654	Cytochrome c, class I
ATC_RS08190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ATC_RS08205	COG0243	molybdopterin cofactor binding
ATC_RS08210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ATC_RS08215	COG1166	arginine decarboxylase activity
ATC_RS08220	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ATC_RS08225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ATC_RS08240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ATC_RS08245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ATC_RS08265	COG1850	ribulose-bisphosphate carboxylase activity
ATC_RS08300	COG0651	ATP synthesis coupled electron transport
ATC_RS08305	COG0649	NAD binding
ATC_RS08305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS08305	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS08310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS08325	COG0076	glutamate decarboxylase activity
ATC_RS08330	COG0163	prenyltransferase activity
ATC_RS08335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ATC_RS08345	COG2022	thiamine diphosphate biosynthetic process
ATC_RS08375	COG2137	regulation of response to DNA damage stimulus
ATC_RS08380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ATC_RS08385	COG1058	Belongs to the CinA family
ATC_RS08385	COG1546	Belongs to the CinA family
ATC_RS08395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ATC_RS08410	COG1489	DNA binding
ATC_RS08415	COG0024	Methionine aminopeptidase
ATC_RS08425	COG2915	High frequency lysogenization protein hflD homolog
ATC_RS08440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ATC_RS08450	COG1196	nuclear chromosome segregation
ATC_RS08455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ATC_RS08470	COG1187	pseudouridine synthase activity
ATC_RS08475	COG0446	pyridine nucleotide-disulphide oxidoreductase
ATC_RS08480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ATC_RS08485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ATC_RS08490	COG0180	Tryptophanyl-tRNA synthetase
ATC_RS08495	COG1994	Peptidase M50
ATC_RS08500	COG0009	L-threonylcarbamoyladenylate synthase
ATC_RS08505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ATC_RS08515	COG3264	Mechanosensitive ion channel
ATC_RS08515	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ATC_RS08520	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ATC_RS08525	COG0531	amino acid
ATC_RS08530	COG5001	Diguanylate cyclase
ATC_RS08530	COG1716	ATPase activity
ATC_RS08535	COG2205	protein histidine kinase activity
ATC_RS08535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ATC_RS08540	COG0587	DNA-directed DNA polymerase activity
ATC_RS08555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ATC_RS08565	COG2860	membrane
ATC_RS08580	COG0438	transferase activity, transferring glycosyl groups
ATC_RS08585	COG0438	transferase activity, transferring glycosyl groups
ATC_RS08590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ATC_RS08610	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ATC_RS08615	COG0196	riboflavin kinase activity
ATC_RS08620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ATC_RS08625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ATC_RS08635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ATC_RS08645	COG4178	(ABC) transporter
ATC_RS08655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ATC_RS08660	COG0860	N-Acetylmuramoyl-L-alanine amidase
ATC_RS08665	COG3118	belongs to the thioredoxin family
ATC_RS08675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ATC_RS08675	COG0425	Belongs to the sulfur carrier protein TusA family
ATC_RS08700	COG0640	Transcriptional regulator
ATC_RS08710	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ATC_RS08725	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ATC_RS08730	COG0084	hydrolase, TatD family'
ATC_RS08735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ATC_RS08740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ATC_RS08760	COG1183	phosphatidylcholine synthase activity
ATC_RS08765	COG0688	phosphatidylethanolamine metabolic process
ATC_RS08770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ATC_RS08780	COG0028	Belongs to the TPP enzyme family
ATC_RS08785	COG1193	negative regulation of DNA recombination
ATC_RS08795	COG0432	Pfam Uncharacterised protein family UPF0047
ATC_RS08830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ATC_RS08835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ATC_RS08840	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ATC_RS08845	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ATC_RS08850	COG0069	glutamate synthase activity
ATC_RS08850	COG0067	glutamate synthase
ATC_RS08850	COG0070	glutamate synthase
ATC_RS08855	COG0493	'glutamate synthase
ATC_RS08860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ATC_RS08880	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ATC_RS08885	COG0330	HflC and HflK could
ATC_RS08890	COG0330	HflC and HflK could
ATC_RS08895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ATC_RS08900	COG1923	regulation of RNA biosynthetic process
ATC_RS08905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ATC_RS08910	COG0424	maF-like protein
ATC_RS08940	COG4974	Belongs to the 'phage' integrase family
ATC_RS08950	COG2433	Pfam Transposase IS66
ATC_RS08955	COG3436	PFAM IS66 Orf2 family protein
ATC_RS08980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ATC_RS08990	COG0640	Transcriptional regulator
ATC_RS09010	COG1484	DNA-dependent DNA replication
ATC_RS09045	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ATC_RS09065	COG0322	excinuclease ABC activity
ATC_RS09075	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ATC_RS09085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ATC_RS09090	COG0148	phosphopyruvate hydratase activity
ATC_RS09095	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ATC_RS09100	COG0504	CTP synthase activity
ATC_RS09230	COG0513	Belongs to the DEAD box helicase family
ATC_RS09245	COG0347	Belongs to the P(II) protein family
ATC_RS09250	COG0505	Belongs to the CarA family
ATC_RS09260	COG0004	ammonium transporteR
ATC_RS09290	COG3852	Histidine kinase
ATC_RS09360	COG1937	Protein conserved in bacteria
ATC_RS09370	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ATC_RS09395	COG2217	Heavy metal translocating P-type atpase
ATC_RS09445	COG2226	methyltransferase
ATC_RS09460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ATC_RS09460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATC_RS09470	COG2814	Major facilitator Superfamily
ATC_RS09485	COG4232	protein-disulfide reductase activity
ATC_RS09505	COG3220	belongs to the UPF0276 family
ATC_RS09520	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ATC_RS09525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ATC_RS09550	COG1017	nitric oxide dioxygenase activity
ATC_RS09550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ATC_RS09570	COG0509	glycine decarboxylation via glycine cleavage system
ATC_RS09600	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ATC_RS09615	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ATC_RS09620	COG1140	nitrate reductase beta subunit
ATC_RS09625	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ATC_RS09630	COG2181	nitrate reductase activity
ATC_RS09640	COG2223	nitrite transmembrane transporter activity
ATC_RS09645	COG3189	MarR family transcriptional regulator
ATC_RS09670	COG1484	DNA-dependent DNA replication
ATC_RS09680	COG0477	Major facilitator Superfamily
ATC_RS09685	COG0583	DNA-binding transcription factor activity
ATC_RS09720	COG0084	hydrolase, TatD family'
ATC_RS09725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ATC_RS09735	COG0628	permease
ATC_RS09740	COG0613	PHP domain protein
ATC_RS09750	COG0628	permease
ATC_RS09765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ATC_RS09780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ATC_RS09785	COG1758	RNA polymerase activity
ATC_RS09795	COG1561	YicC-like family, N-terminal region
ATC_RS09800	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ATC_RS09810	COG4232	protein-disulfide reductase activity
ATC_RS09815	COG1324	tolerance protein
ATC_RS09850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ATC_RS09860	COG0582	viral genome integration into host DNA
ATC_RS09990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ATC_RS10040	COG1484	DNA-dependent DNA replication
ATC_RS10120	COG3451	type IV secretory pathway VirB4
ATC_RS10190	COG4964	Belongs to the GSP D family
ATC_RS10205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ATC_RS10250	COG2805	Type II/IV secretion system protein
ATC_RS10335	COG3077	Addiction module antitoxin, RelB DinJ family
ATC_RS10340	COG3041	Addiction module toxin RelE StbE family
ATC_RS10405	COG1484	DNA-dependent DNA replication
ATC_RS10415	COG0210	DNA helicase
ATC_RS10450	COG0741	lytic transglycosylase activity
ATC_RS10465	COG0629	single-stranded DNA binding
ATC_RS10495	COG4584	PFAM Integrase catalytic
ATC_RS10500	COG1484	DNA-dependent DNA replication
ATC_RS10585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ATC_RS10720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ATC_RS10725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ATC_RS10730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ATC_RS10745	COG3025	triphosphatase activity
ATC_RS10755	COG0308	aminopeptidase N
ATC_RS10765	COG0542	response to heat
ATC_RS10770	COG2211	Major facilitator Superfamily
ATC_RS10775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ATC_RS10780	COG1469	GTP cyclohydrolase I activity
ATC_RS10785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ATC_RS10790	COG0142	geranyltranstransferase activity
ATC_RS10800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ATC_RS10805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ATC_RS10810	COG1862	Preprotein translocase
ATC_RS10815	COG0343	queuine tRNA-ribosyltransferase activity
ATC_RS10820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ATC_RS10825	COG1253	flavin adenine dinucleotide binding
ATC_RS10840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ATC_RS10850	COG0285	dihydrofolate synthase activity
ATC_RS10855	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ATC_RS10860	COG0159	tryptophan synthase activity
ATC_RS10865	COG0133	tryptophan synthase activity
ATC_RS10870	COG0135	phosphoribosylanthranilate isomerase activity
ATC_RS10875	COG0101	tRNA pseudouridine synthase activity
ATC_RS10885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ATC_RS10900	COG0746	molybdenum cofactor guanylyltransferase activity
ATC_RS10905	COG1763	Mo-molybdopterin cofactor biosynthetic process
ATC_RS10910	COG0303	'Molybdopterin
ATC_RS10915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ATC_RS10935	COG0415	Belongs to the DNA photolyase family
ATC_RS10945	COG1294	oxidase, subunit
ATC_RS10950	COG1271	oxidase subunit
ATC_RS10965	COG0842	Transport permease protein
ATC_RS10970	COG0842	Transport permease protein
ATC_RS10975	COG1131	(ABC) transporter
ATC_RS10985	COG2814	Major facilitator Superfamily
ATC_RS10990	COG0589	response to stress
ATC_RS11000	COG0047	phosphoribosylformylglycinamidine synthase activity
ATC_RS11000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ATC_RS11005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ATC_RS11010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ATC_RS11020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ATC_RS11030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ATC_RS11035	COG0459	protein refolding
ATC_RS11045	COG2046	Belongs to the sulfate adenylyltransferase family
ATC_RS11045	COG0529	Catalyzes the synthesis of activated sulfate
ATC_RS11055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ATC_RS11060	COG3258	Cytochrome c
ATC_RS11070	COG1333	cytochrome c biogenesis protein
ATC_RS11080	COG0737	Belongs to the 5'-nucleotidase family
ATC_RS11105	COG1845	cytochrome c oxidase, subunit III
ATC_RS11110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ATC_RS11115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ATC_RS11120	COG1484	DNA-dependent DNA replication
ATC_RS11135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ATC_RS11140	COG0154	amidase activity
ATC_RS11145	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ATC_RS11180	COG3394	polysaccharide catabolic process
ATC_RS11185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ATC_RS11195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ATC_RS11205	COG1657	PFAM Prenyltransferase squalene oxidase
ATC_RS11210	COG1562	ergosterol biosynthetic process
ATC_RS11215	COG1136	(ABC) transporter
ATC_RS11220	COG0577	efflux transmembrane transporter activity
ATC_RS11235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ATC_RS11250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ATC_RS11255	COG1127	ABC transporter
ATC_RS11260	COG1538	Outer membrane efflux protein
ATC_RS11305	COG4115	mRNA cleavage
ATC_RS11310	COG2161	toxin-antitoxin pair type II binding
ATC_RS11325	COG0358	DNA primase activity
ATC_RS11330	COG1193	negative regulation of DNA recombination
ATC_RS11335	COG1610	YqeY-like protein
ATC_RS11340	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ATC_RS11350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ATC_RS11355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ATC_RS11365	COG0326	Molecular chaperone. Has ATPase activity
ATC_RS11370	COG2363	Small membrane protein
ATC_RS11385	COG2943	transferase activity, transferring hexosyl groups
ATC_RS11400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ATC_RS11415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATC_RS11420	COG1271	oxidase subunit
ATC_RS11425	COG1294	oxidase, subunit
ATC_RS11440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ATC_RS11460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ATC_RS11465	COG0037	tRNA processing
ATC_RS11470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ATC_RS11470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ATC_RS11480	COG0736	holo-[acyl-carrier-protein] synthase activity
ATC_RS11485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ATC_RS11490	COG1381	Involved in DNA repair and RecF pathway recombination
ATC_RS11495	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ATC_RS11500	COG0571	ribonuclease III activity
ATC_RS11510	COG0681	Belongs to the peptidase S26 family
ATC_RS11515	COG0481	GTPase activity
ATC_RS11520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ATC_RS11535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ATC_RS11550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ATC_RS11555	COG4988	ABC transporter
ATC_RS11580	COG1214	PFAM Peptidase M22, glycoprotease
ATC_RS11585	COG1199	ATP-dependent helicase activity
ATC_RS11595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ATC_RS11600	COG0791	NLP P60 protein
ATC_RS11620	COG0586	Pfam SNARE associated Golgi protein
ATC_RS11635	COG0583	DNA-binding transcription factor activity
ATC_RS11705	COG0095	Lipoate-protein ligase
ATC_RS11715	COG0509	glycine decarboxylation via glycine cleavage system
ATC_RS11725	COG0509	glycine decarboxylation via glycine cleavage system
ATC_RS11730	COG2048	Heterodisulfide reductase, subunit B
ATC_RS11760	COG2210	Belongs to the sulfur carrier protein TusA family
ATC_RS11765	COG0425	Belongs to the sulfur carrier protein TusA family
ATC_RS11770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ATC_RS11775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ATC_RS11780	COG3302	dmso reductase anchor subunit
ATC_RS11785	COG0437	4 iron, 4 sulfur cluster binding
ATC_RS11790	COG0243	molybdopterin cofactor binding
ATC_RS11800	COG0315	cyclic pyranopterin monophosphate synthase activity
ATC_RS11810	COG5000	phosphorelay sensor kinase activity
ATC_RS11840	COG3439	Domain of unknown function DUF302
ATC_RS11845	COG0737	Belongs to the 5'-nucleotidase family
ATC_RS11850	COG1077	Cell shape determining protein MreB Mrl
ATC_RS11855	COG1792	Involved in formation and maintenance of cell shape
ATC_RS11865	COG0768	penicillin binding
ATC_RS11870	COG0772	Belongs to the SEDS family
ATC_RS11875	COG1686	Belongs to the peptidase S11 family
ATC_RS11885	COG0321	lipoyl(octanoyl) transferase activity
ATC_RS11890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ATC_RS11940	COG0751	glycine-tRNA ligase activity
ATC_RS11945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ATC_RS11975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ATC_RS11980	COG2154	pterin-4-alpha-carbinolamine dehydratase
ATC_RS11985	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ATC_RS11995	COG3023	N-Acetylmuramoyl-L-alanine amidase
ATC_RS12005	COG0450	alkyl hydroperoxide reductase
ATC_RS12010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ATC_RS12035	COG3039	Transposase
ATC_RS12040	COG0247	lactate metabolic process
ATC_RS12045	COG0277	FAD linked oxidase domain protein
ATC_RS12050	COG0277	FAD linked oxidase domain protein
ATC_RS12075	COG1929	Belongs to the glycerate kinase type-1 family
ATC_RS12120	COG0242	peptide deformylase activity
ATC_RS12130	COG0235	Class ii aldolase
ATC_RS12135	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ATC_RS12145	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ATC_RS12155	COG0564	pseudouridine synthase activity
ATC_RS12170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ATC_RS12170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ATC_RS12185	COG0045	succinate-CoA ligase (ADP-forming) activity
ATC_RS12190	COG0538	isocitrate dehydrogenase activity
ATC_RS12195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ATC_RS12205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ATC_RS12210	COG1388	LysM domain
ATC_RS12210	COG0741	lytic transglycosylase activity
ATC_RS12220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ATC_RS12230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ATC_RS12235	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ATC_RS12245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ATC_RS12250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ATC_RS12255	COG0137	argininosuccinate synthase activity
ATC_RS12270	COG0328	RNA-DNA hybrid ribonuclease activity
ATC_RS12275	COG2226	methyltransferase
ATC_RS12280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ATC_RS12285	COG0612	Peptidase, M16
ATC_RS12290	COG1185	polyribonucleotide nucleotidyltransferase activity
ATC_RS12295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ATC_RS12300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ATC_RS12305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ATC_RS12310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ATC_RS12315	COG0195	Participates in both transcription termination and antitermination
ATC_RS12320	COG0779	Required for maturation of 30S ribosomal subunits
ATC_RS12360	COG1266	CAAX protease self-immunity
ATC_RS12365	COG1376	ErfK ybiS ycfS ynhG family protein
ATC_RS12365	COG1388	LysM domain
ATC_RS12375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ATC_RS12380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ATC_RS12390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ATC_RS12400	COG0492	ferredoxin-NADP+ reductase activity
ATC_RS12405	COG1193	negative regulation of DNA recombination
ATC_RS12415	COG0585	pseudouridine synthase activity
ATC_RS12420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ATC_RS12425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ATC_RS12430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ATC_RS12435	COG0560	Phosphoserine phosphatase
ATC_RS12440	COG0678	peroxiredoxin activity
ATC_RS12440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ATC_RS12445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ATC_RS12455	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ATC_RS12480	COG2003	Belongs to the UPF0758 family
ATC_RS12485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ATC_RS12490	COG0756	dUTP diphosphatase activity
ATC_RS12500	COG0717	Belongs to the dCTP deaminase family
ATC_RS12505	COG0489	protein tyrosine kinase activity
ATC_RS12515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ATC_RS12520	COG0484	heat shock protein binding
ATC_RS12525	COG0443	Heat shock 70 kDa protein
ATC_RS12530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ATC_RS12535	COG1420	regulation of RNA biosynthetic process
ATC_RS12540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ATC_RS12545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ATC_RS12550	COG3046	protein related to deoxyribodipyrimidine photolyase
ATC_RS12585	COG1028	Short-chain dehydrogenase reductase Sdr
ATC_RS12630	COG4221	oxidoreductase activity
ATC_RS12640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ATC_RS12650	COG0312	modulator of DNA gyrase
ATC_RS12655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ATC_RS12660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ATC_RS12665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ATC_RS12670	COG0149	triose-phosphate isomerase activity
ATC_RS12675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ATC_RS12685	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS12690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS12695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS12700	COG0649	NAD binding
ATC_RS12705	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ATC_RS12715	COG1034	ATP synthesis coupled electron transport
ATC_RS12720	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ATC_RS12725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS12735	COG0713	ATP synthesis coupled electron transport
ATC_RS12750	COG1007	ATP synthesis coupled electron transport
ATC_RS12765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ATC_RS12770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ATC_RS12775	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ATC_RS12780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ATC_RS12785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ATC_RS12790	COG0072	phenylalanine-tRNA ligase activity
ATC_RS12795	COG0776	regulation of translation
ATC_RS12810	COG1116	anion transmembrane transporter activity
ATC_RS12845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS12850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS12850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS12850	COG0649	NAD binding
ATC_RS12855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS12855	COG0649	NAD binding
ATC_RS12855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS12860	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ATC_RS12870	COG1034	ATP synthesis coupled electron transport
ATC_RS12875	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ATC_RS12880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ATC_RS12895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ATC_RS12905	COG1007	ATP synthesis coupled electron transport
ATC_RS12915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ATC_RS12935	COG0735	belongs to the Fur family
ATC_RS12940	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ATC_RS12950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ATC_RS12955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ATC_RS12975	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ATC_RS12985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ATC_RS12990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ATC_RS13040	COG1872	DUF167
ATC_RS13045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ATC_RS13055	COG1566	PFAM secretion protein HlyD family protein
ATC_RS13065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ATC_RS13090	COG0543	2 iron, 2 sulfur cluster binding
ATC_RS13090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ATC_RS13095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ATC_RS13100	COG0390	transport system, permease component
ATC_RS13105	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ATC_RS13110	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ATC_RS13115	COG0501	Belongs to the peptidase M48B family
ATC_RS13120	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ATC_RS13125	COG2226	methyltransferase
ATC_RS13130	COG0596	Alpha beta hydrolase
ATC_RS13135	COG0156	8-amino-7-oxononanoate synthase activity
ATC_RS13140	COG1040	competence protein
ATC_RS13145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ATC_RS13150	COG0477	Major facilitator Superfamily
ATC_RS13155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ATC_RS13160	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ATC_RS13165	COG1519	Transferase
ATC_RS13175	COG0859	PFAM glycosyl transferase family 9
ATC_RS13200	COG0438	transferase activity, transferring glycosyl groups
ATC_RS13210	COG0463	Glycosyl transferase, family 2
ATC_RS13215	COG0494	nUDIX hydrolase
ATC_RS13225	COG0653	protein targeting
ATC_RS13235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ATC_RS13240	COG0625	glutathione transferase activity
ATC_RS13255	COG2001	Belongs to the MraZ family
ATC_RS13260	COG0275	rRNA processing
ATC_RS13275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ATC_RS13280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ATC_RS13285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ATC_RS13290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ATC_RS13295	COG0772	Belongs to the SEDS family
ATC_RS13300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ATC_RS13305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ATC_RS13310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ATC_RS13315	COG1181	Belongs to the D-alanine--D-alanine ligase family
ATC_RS13320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ATC_RS13335	COG0058	SHG alpha-glucan phosphorylase activity
ATC_RS13340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ATC_RS13350	COG0793	Belongs to the peptidase S41A family
ATC_RS13355	COG0693	protein deglycase activity
ATC_RS13360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ATC_RS13365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ATC_RS13370	COG0542	response to heat
ATC_RS13375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ATC_RS13380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ATC_RS13380	COG2813	Specifically methylates the guanine in position
ATC_RS13385	COG0625	glutathione transferase activity
ATC_RS13395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ATC_RS13430	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ATC_RS13440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ATC_RS13445	COG0768	penicillin binding
ATC_RS13455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ATC_RS13465	COG0823	Involved in the tonB-independent uptake of proteins
ATC_RS13475	COG0583	DNA-binding transcription factor activity
ATC_RS13485	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ATC_RS13490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ATC_RS13495	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ATC_RS13500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ATC_RS13505	COG3047	cAMP biosynthetic process
ATC_RS13505	COG2885	chlorophyll binding
ATC_RS13510	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ATC_RS13515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ATC_RS13525	COG0165	Argininosuccinate lyase
ATC_RS13540	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ATC_RS13550	COG1611	Belongs to the LOG family
ATC_RS13555	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ATC_RS13555	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ATC_RS13560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ATC_RS13565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ATC_RS13570	COG1333	cytochrome c biogenesis protein
ATC_RS13575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ATC_RS13585	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ATC_RS13590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ATC_RS13595	COG3386	PFAM SMP-30 Gluconolaconase
ATC_RS13605	COG2814	Major facilitator Superfamily
ATC_RS13615	COG0488	(ABC) transporter
ATC_RS13725	COG4964	Belongs to the GSP D family
ATC_RS13795	COG0792	nuclease activity
ATC_RS13800	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ATC_RS13805	COG0277	FAD linked oxidase domain protein
ATC_RS13830	COG0583	DNA-binding transcription factor activity
ATC_RS13855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ATC_RS13865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ATC_RS13870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ATC_RS13880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ATC_RS13885	COG2833	Protein of unknown function (DUF455)
ATC_RS13915	COG0386	Belongs to the glutathione peroxidase family
ATC_RS13945	COG2095	MarC family integral membrane protein
ATC_RS13955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ATC_RS13960	COG1051	belongs to the nudix hydrolase family
ATC_RS13965	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ATC_RS13975	COG0217	transcriptional regulatory protein
ATC_RS13980	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ATC_RS13985	COG0632	four-way junction helicase activity
ATC_RS13990	COG2255	four-way junction helicase activity
ATC_RS13995	COG0824	Thioesterase
ATC_RS14015	COG0823	Involved in the tonB-independent uptake of proteins
ATC_RS14020	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ATC_RS14025	COG0602	queuosine metabolic process
ATC_RS14040	COG0181	hydroxymethylbilane synthase activity
ATC_RS14050	COG0113	porphobilinogen synthase activity
ATC_RS14060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ATC_RS14065	COG0477	Major facilitator Superfamily
ATC_RS14070	COG1272	protein, Hemolysin III
ATC_RS14100	COG0424	maF-like protein
ATC_RS14115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ATC_RS14125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ATC_RS14140	COG1560	Kdo2-lipid A biosynthetic process
ATC_RS14150	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ATC_RS14155	COG0706	membrane insertase activity
ATC_RS14160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ATC_RS14165	COG0594	ribonuclease P activity
ATC_RS14170	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ATC_RS14175	COG1127	ABC transporter
ATC_RS14180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ATC_RS14185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ATC_RS14200	COG1131	(ABC) transporter
ATC_RS14205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ATC_RS14210	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ATC_RS14220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ATC_RS14235	COG0018	arginyl-trna synthetase
ATC_RS14240	COG3264	Mechanosensitive ion channel
ATC_RS14240	COG1196	nuclear chromosome segregation
ATC_RS14245	COG0477	Major facilitator Superfamily
ATC_RS14250	COG0583	DNA-binding transcription factor activity
ATC_RS14260	COG0708	Exodeoxyribonuclease III
ATC_RS14270	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ATC_RS14275	COG0625	glutathione transferase activity
ATC_RS14285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ATC_RS14290	COG1047	Peptidyl-prolyl cis-trans
ATC_RS14295	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ATC_RS14300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ATC_RS14320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ATC_RS14325	COG0237	dephospho-CoA kinase activity
ATC_RS14330	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ATC_RS14335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ATC_RS14350	COG0739	heme binding
ATC_RS14350	COG1196	nuclear chromosome segregation
ATC_RS14350	COG0741	lytic transglycosylase activity
ATC_RS14355	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ATC_RS14365	COG2264	protein methyltransferase activity
ATC_RS14370	COG0439	Biotin carboxylase
ATC_RS14375	COG0511	ligase activity, forming carbon-carbon bonds
ATC_RS14380	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ATC_RS14385	COG0778	Nitroreductase
ATC_RS14400	COG1555	photosystem II stabilization
ATC_RS14405	COG0537	adenosine 5'-monophosphoramidase activity
ATC_RS14410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ATC_RS14415	COG0352	thiamine-phosphate diphosphorylase activity
ATC_RS14420	COG0351	phosphomethylpyrimidine kinase
ATC_RS14430	COG1028	Short-chain dehydrogenase reductase Sdr
ATC_RS14460	COG0187	DNA topoisomerase II activity
ATC_RS14475	COG0543	2 iron, 2 sulfur cluster binding
ATC_RS14475	COG0493	'glutamate synthase
ATC_RS14535	COG2204	response regulator
ATC_RS15820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ATC_RS15910	COG0741	lytic transglycosylase activity
ATC_RS15920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ATC_RS16000	COG0582	viral genome integration into host DNA
ATC_RS16040	COG3561	AntA/AntB antirepressor
ATC_RS16045	COG0741	lytic transglycosylase activity
ATC_RS16070	COG3179	chitinase
ATC_RS16075	COG3179	chitinase